TRAC-Trends in Analytical Chemistry

Article	Citations
Editorial Board	630
Editorial	443
Editorial Board	261
Mass spectrometry based metabolomics of volume-restricted in-vivo brain samples: Actual status and the way forward	187
Toxicity mechanisms and alleviation strategies of micro/nanoplastics to animals: A review	179
Concomitant presence of nanosized plastics and metal(loid)s: is there cause for alarm? State-of-the-art and recommendations for future studies	141
Design strategies and applications of responsive metal-based luminescence probes in the bioanalysis	140
Single-cell spatial (scs) omics: Recent developments in data analysis	139
Unique role of molecular imaging probes for viral infection	135
Greenness of analytical methods for the study of metal-containing nanoparticles in biomedical samples, personal care products and food	132
Single-molecule detection-based super-resolution imaging in single-cell analysis: Inspiring progress and future prospects	127
Playing with biological selectivity: Antimicrobial peptides and bacteriophages-based optical biosensors for pathogenic bacteria detection	125
Multidimensional single-cell analysis: Diverse strategies and emerging applications in the life sciences	124
Recent advances in cell membrane-coated technology for drug discovery from natural products	124
Applications of thread-based microfluidics: Approaches and options for detection	121
Nanofibers prepared from synthetic polymers and biopolymers as advanced extraction materials for sample preparation prior to liquid chromatography	121
Analytical and biomedical applications of microfluidics in traditional Chinese medicine research	120
Micro- and nanoscale sensing of volatile organic compounds for early-stage cancer diagnosis	120
Galectins detection for the diagnosis of chronic diseases: An emerging biosensor approach	118
From exogenous to endogenous: Advances in in vivo sampling in living systems	116
3D printed microfluidics for cell biological applications	115
Advances and challenges in the selective extraction of low molecular weight carbohydrates using ionic liquids and deep eutectic solvents	109
Advances in interferometric sensors for the detection of food contaminants	109
Electrochemical sensing of human hormones	109
Microscale thermophoresis (MST) and spectral shift (SpS) in drug discovery	108

Advancements in detection techniques for per- and polyfluoroalkyl substances: A comprehensive review	108
Mapping micro(nano)plastics in various organ systems: Their emerging links to human diseases?	107
Recent advancements in biosensors for diagnosis of ovarian cancer: Analytical approaches	101
Advances in optical devices for the detection of contaminants in food and water	101
Current issues and perspectives in nanosensors-based artificial olfactory systems for breath diagnostics and environmental exposure monitoring	98
Advancements in magnetic aptasensors: Recent progress and future trends in biosensor technology	98
Recent advances in metal–organic frameworks as emerging platforms for immunoassays	96
Microneedle wearables in advanced microsystems: Unlocking next-generation biosensing with AI	96
High-throughput optical assays for sensing serine hydrolases in living systems and their applications	95
High-end ion mobility mass spectrometry: A current review of analytical capacity in omics applications and structural investigations	94
Advance on the sample preparation and analytical methods for water disinfection byproducts	93
Recent advances in flexible sensors: From sensing materials to detection modes	93
Recent developments and future perspectives of chiral liquid chromatography for food safety and quality	92
Optical biosensors utilising viral receptors ACE2 and ACE2 mimics	92
Novel developments in capillary electrophoresis miniaturization, sampling, detection and portability: An overview of the last decade	92
On-line supercritical fluid extraction-supercritical fluid chromatography (SFE-SFC) at a glance: A coupling story	92
High-throughput mass spectrometry imaging of biological systems: Current approaches and future directions	90
A comprehensive review on ecological effects of microplastic pollution: An interaction with pollutants in the ecosystems and future perspectives	89
Applications of nanomaterial-based chemiluminescence sensors in environmental analysis	89
Molecularly imprinted polymer-modified carbon paste electrodes (MIP-CPE): A review on sensitive electrochemical sensors for pharmaceutical determinations	88
CRISPR-Cas assisted diagnostics: A broad application biosensing approach	88
Recent chemical mixing devices for time-resolved serial femtosecond crystallography	88
Exhaled volatile organic compounds and respiratory disease: Recent progress and future outlook	87
Hydrogel sorbent-based sample preparation processes as green alternatives for the extraction of organic contaminants followed by chromatographic analysis	86
Ion mobility Mass Spectrometry for Glycomics: Challenges and Opportunities When Met with Artificial Intelligence	86
Deciphering the research of Micro(nano)plastics: An in-depth bibliometric expedition into ecotoxicological impacts and research trends	86
Recent advancements in polyaniline-based biosensors for diagnosis of cancers: A comprehensive review	86
Analytical methods for biomonitoring organic chemical hazards in saliva: A systematic review	86
Rediscovering similarity analysis of analytical signal: A not well-known mainstay of chemometrics	85
Recent developments of small-molecule fluorescent probes for the detection of hydroxyl radical in biological systems	84
Cellulose immobilization strategies for paper-based immunoassays	83
Recent advances in electrochemical sensing of cocaine: A review	83
Mass spectrometry for structural elucidation and sequencing of carbohydrates	83
Editorial Board	82
Neonatal point-of-care testing	81
Synergizing Machine Learning and fluorescent biomolecules: A new era in sensing platforms	81
Probing protein higher-order structures by native capillary electrophoresis-mass spectrometry	81
Fluorogenic toolbox for visualizing protein aggregation: From designing principles to biological application	80
Advances in analytical technologies detecting and characterizing noncovalent interactions for fragment-based drug discovery	79
Tracing per- and polyfluoroalkyl substances (PFASs) in the aquatic environment: Target analysis and beyond	78
The highest yield, or greener solvents? Latest trends in quercetin extraction methods	78
Bio-inspired approaches for explosives detection	77
Recent developments in sample pretreatment techniques for the determination of fluoroquinolones in foods	77
Recent advances in centrifugal microfluidic chip-based loop-mediated isothermal amplification	77
Emerging single-cell microfluidic technology for microbiology	76
Advancement in exosome isolation and label-free detection towards clinical diagnosis	76
Machine learning-assisted carbon dots synthesis and analysis: State of the art and future directions	76
Recent advances in single-entity electrochemistry for metal nanoparticle, nanodroplet, and bio-entity analysis	76
Trends in electrochemical nanosensors for the analysis of antioxidants	75
Recent trends and advancements in electrochemiluminescence biosensors for human virus detection	75

Potential applications and challenges of novel ambient ionization mass spectrometric techniques in the emergency care for acute poisoning	74
Recent advances towards the use of deep eutectic solvents and cyclodextrins in the extraction of food contaminants: From traditional sample pretreatment techniques to green microextraction and beyond	74
Boosting comprehensive two-dimensional chromatography with artificial intelligence: Application to food-omics	73
A critical review of acrylamide green extraction and determination in food matrices: Current insights and future perspectives	73
The multipurpose application of resazurin in micro-analytical techniques: Trends from the microbial, catalysis and single molecule detection assays	72
Novel sorptive extraction techniques in bioanalysis evaluated by Blue Applicability Grade Index: The paradigm of fabric phase sorptive extraction and capsule phase microextraction	72
Microfluidics for chiral separation of biomolecules	71
Analytical performance of electrochemical surface-enhanced Raman spectroscopy: A critical review	70
Comprehensive approaches to expanding CRISPR biosensor applications beyond nucleic acid targets	70
Liquid crystal-based biosensors as lab-on-chip tools: Promising for future on-site detection test kits	67
Optical microscopic and spectroscopic detection of exosomes	67
Applications of metal organic frameworks in point of care testing	67
Microplastic aging processes: Environmental relevance and analytical implications	66
Merging microfluidics with luminescence immunoassays for urgent point-of-care diagnostics of COVID-19	66
Recent advances on graphene and graphene oxide as extraction materials in solid-phase (micro)extraction	66
Development of biomimetic phospholipid membrane chromatography for drug discovery: A comprehensive review	66
Evolution in understandings of the design, optimization, and application of sorbent-based extraction devices	66
Nanomaterial-based chemiluminescence systems for tracing of reactive oxygen species in biosensors	66
Organ-on-a-chip platforms integrated with biosensors for precise monitoring of the cells and cellular microenvironment	65
Will data analytics revolution finally bring SERS to the clinic?	64
A new approach to identifying pathogens, with particular regard to viruses, based on capillary electrophoresis and other analytical techniques	64
Advances in X-ray neuroimaging: Bridging scales from molecular to organ architectures	63
Application of chemometrics and related advanced data handling in chemical separations	63
Advances in gas pressure-based portable biosensing	63
Capillary electrophoresis and Raman: Can we ever expect light at the end of the tunnel?	63
The aerobiological pathway of natural respiratory viral aerosols	63
Corrigendum to “Combining chemometrics and paper-based analytical devices for sensing: An overview” [TrAC. Trends Anal. Chem. 164 (2023) 117091]	63
Magnetic-based microextraction systems for the determination of emerging contaminants in environmental liquid samples	63
Towards a harmonized identification scoring system in LC-HRMS/MS based non-target screening (NTS) of emerging contaminants	62
Recent advances in the detection of multiple microRNAs	62
Recent progress and challenges in biosensing of carcinoembryonic antigen	62
Green photonic biosensing: Approaching sustainability in point-of-care diagnostics	61
Functional materials and chemicals in electromembrane extraction	61
Nanotechnology-assisted microfluidic systems for chemical sensing, biosensing, and bioanalysis	61
Recent advances in separation methods for characterization of glutathione metabolism and dietary supplementation	60
Recent progress in microfluidic biosensors with different driving forces	60
Recent trends in analytical measures of microplastic in soil and toxicopathological risk assessment in earthworms	59
Early-diagnosis of major depressive disorder: From biomarkers to point-of-care testing	59
Microplastics in soil aggregates: Analytical methods, occurrence patterns, impact analyses and removal approaches	59
Metal-organic frameworks as an alternative smart sensing platform for designing molecularly imprinted electrochemical sensors	59
Point of care testing of sports biomarkers: Potential applications, recent advances and future outlook	58
Enantioselective separation techniques in forensic analysis and clinical toxicology	58
Biomedical application of hyperbranched polymers: Recent Advances and challenges	58
Microplastics and nanoplastics in food, water, and beverages; part I. occurrence	58
Determination and assessment of contamination of toxic chemical elements in soils – Review	58
Rapid in-situ synthesis of metal organic frameworks for biosensors	57
Fate and impact of nanoplastics in the human digestive environment after oral exposure: A common challenge for toxicology and chemistry	57
Recent advances in droplet microfluidics for single-cell analysis	57
Sample preparation and mass spectrometry for determining mycotoxins, hazardous fungi, and their metabolites in the environment, food, and healthcare	56
Emerging ELISA derived technologies for in vitro diagnostics	56
3D printed microfluidics for bioanalysis: A review of recent advancements and applications	56
Towards a rational and efficient risk assessment for microplastics	56
Sensitive enzyme-free electrochemical sensors for the detection of pesticide residues in food and water	56
Recent advances in metal/covalent organic framework-based materials for photoelectrochemical sensing applications	56
Editorial Board	55
A review of organic aerosol speciation by comprehensive two-dimensional gas chromatography	55
Recent advances in nano/microfabricated substrate platforms and artificial intelligence for practical surface-enhanced Raman scattering-based bioanalysis	55
Capillary isoelectric focusing – The role of markers of isoelectric point and recent applications in the field	55
Modern sorbent-based sample preparation methods for the determination of analytes of forensic interest: A dual-tool approach for evaluation of greenness and practical utility	54
Single-cell metabolite analysis by electrospray ionization mass spectrometry	54
Raman scattering applied to human breath analysis	54
Caenorhabditis elegans (C. elegans) sample preparation for metabolomics and lipidomics analysis – A review	54
Nanomaterials meet microfluidics: Improved analytical methods and high-throughput synthetic approaches	53
Transient OCP-apatite epitaxy controls bone mineralization. An X-ray total scattering study	53
Deep eutectic solvents for microextraction of endocrine disruptor contaminants from water and food: Review	53
Advances in 3D printed sensors for food analysis	53
Corrigendum to “Molecularly imprinted polymers for the detection of volatile biomarkers” [Trends Anal. Chem. 177 (2024) 117783]	53
Foodomics in health: Advanced techniques for studying the bioactive role of foods	53
Polymer inclusion membranes based Optode: Recent advances and perspectives	53
Portable X-ray fluorescence (pXRF) as a powerful and trending analytical tool for in situ food samples analysis: A comprehensive review of application - State of the art	52
Lateral flow assays for food analyses: Food contaminants, allergens, toxins, and beyond	52
Nano-engineered screen-printed electrodes: A dynamic tool for detection of viruses	52
Membrane inlet mass spectrometry (MIMS) for analysis of water disinfection byproducts: Recent advances	52
Recent advances in microfluidic devices for foodborne pathogens detection	51
Untargeted chromatographic methods coupled with chemometric strategies for the analysis of food and related samples	51
Recent progress in molecular diagnostics: The synergy of rolling circle amplification and CRISPR/Cas systems (2018–2024) – A concise review	51
Modern automated sample preparation for the determination of organic compounds: A review on robotic and on-flow systems	51
Development of laser-induced breakdown spectroscopy based spectral tandem technology: A topical review	51
From untargeted chemical profiling to peak tables – A fully automated AI driven approach to untargeted GC-MS	51
The twelve goals of circular analytical chemistry	51

Recent advances of chiral metal-organic frameworks in analytic chemistry	51
In situ solid phase microextraction sampling of analytes from living human objects for mass spectrometry analysis	51
Nanomaterials-based electrochemical sensors and biosensors for the detection of non-steroidal anti-inflammatory drugs	51
Portable sensors in precision agriculture: Assessing advances and challenges in soil nutrient determination	50
Synthesis and characterization of TiO2 nanomaterials for sensing environmental volatile compounds (VOCs): A review	50
Recent advancements in nucleic acid detection with microfluidic chip for molecular diagnostics	50
Recent advances in organelle-specific two-photon small-molecule fluorescent probes for bioanalysis in live tissues	50
Recent trends in carbon-based microelectrodes as electrochemical sensors for neurotransmitter detection: A review	49
Plasmonic biosensors: Towards fully operative detection platforms for biomedical application and its potential for the diagnosis of autoimmune diseases	49
Recent advances on portable sensing and biosensing assays applied for detection of main chemical and biological pollutant agents in water samples: A critical review	49
Current trends of unsustainable plastic production and micro(nano)plastic pollution	49
Miniaturized solid phase extraction techniques for different kind of pollutants analysis: State of the art and future perspectives – PART 2	49
State-of-the-art application of mass spectrometry imaging covering the medicinal and edible plants	48
Editorial Board	48
Challenges and opportunities in the development of planar potentiometric sensors for point-of-care analysis	48
Editorial Board	48
Uric acid biosensors based on molecular recognition: Classifications, advances, and prospects	48
Advances in the analysis of odorous substances derived from drinking water disinfection	47
Engineering activatable nanoprobes based on time-resolved luminescence for chemo/biosensing	47
Recent advances in microfluidic single-cell analysis and its applications in drug development	47
Corrigendum to “Offline preparative separation methods based on electromigration: An overview and current trends” [Trac. Trends Anal. Chem. 170 (2023) 117428]	47
Polar organic pollutants, micro-nano plastics and nanomaterials: Analytical techniques to reveal the still invisible human physico-chemical exposome	47
Nonlinear optical characterization of pharmaceutical formulations	47
Radiometric strategy to track nanopesticides: An important approach to understand the fate, mechanisms of action and toxicity	47
Recent advances of cellulose nanofiber-based materials in cell culture: From population to single-cell	46
MOFs/COFs-based hybrids for agricultural sensors: Current state of art and beyond	46
Versatile sensing strategies based on emerging programmable prokaryotic Argonautes: From nucleic acid to non-nucleic acid targets	46
Biosensing based on lossy mode resonances	45
Tracking indoor volatile organic compounds with online mass spectrometry	45
Variable electric field and atomic percentage of doping on the displacement process of C20 molecules in a nanotube with molecular dynamics simulation	45
Assessing the availability of trace metals including rare earth elements in deep ocean waters of the Clarion Clipperton Zone, NE Pacific: Application of an in situ DGT passive sampling method	45
Perspectives and challenges in extracellular vesicles untargeted metabolomics analysis	45
Exploring advanced materials: Harnessing the synergy of inverse gas chromatography and artificial vision intelligence	45
Recent advances in exhaled breath sample preparation technologies for drug of abuse detection	45
Recent advances on G-quadruplex for biosensing, bioimaging and cancer therapy	44
Advances in terahertz time-domain spectroscopy of pharmaceutical solids: A review	44
Engineered aptamer for the analysis of cells	44
Thermal shift assay for protein–ligand dissociation constant determination	44
Deep learning for near-infrared spectral data modelling: Hypes and benefits	44
Recent advances in microfluidic sensors for nutrients detection in water	44
Functionalized magnetic nanoparticles as powerful sorbents and stationary phases for the extraction and chromatographic applications	43
The review of nanoplastics in plants: Detection, analysis, uptake, migration and risk	43
Update of high-intensity ultrasound applications for the extraction of pectin from agri-food by-products	43
Functionalized magnetic nanoparticles for the separation and purification of proteins and peptides	43
Advances in nanomaterial-based microfluidic platforms for on-site detection of foodborne bacteria	43
Recent progress of gas sensors based on metal oxide composites derived from bimetallic metal-organic frameworks	42
Plastic problem solved? Environmental implications of synthetic hydrophilic polymers across ecosystem boundaries	42
Emerging trends in green carbon dots coated with molecularly imprinted polymers for sensor platforms	42
Cutting-edge progress in carbon nanomaterial-functionalized silver nanoparticles for enhanced optical and electrochemical sensing applications	42
Updated overview of QuEChERS applications in food, environmental and biological analysis (2020–2023)	42
Biomarkers in the diagnosis of wounds infection: An analytical perspective	42
Forensic drug screening by liquid chromatography hyphenated with high-resolution mass spectrometry (LC-HRMS)	42
Green synthesis and characterization of carbon-based materials for sensitive detection of heavy metal ions	42
Carbon dots based fluorescence methods for the detections of pesticides and veterinary drugs: Response mechanism, selectivity improvement and application	42
An overview of analytical methods for enantiomeric determination of chiral pollutants in environmental samples and biota	41
Fluorescent probes based on bioorthogonal reactions: Construction strategies and applications	41
Staining methodologies for microplastics screening	41
Porous material-based sorbent coatings in solid-phase microextraction technique: Recent trends and future perspectives	41
Microfluidic trends in drug screening and drug delivery	41
Advancements in screening systems for active ingredients in traditional Chinese medicines using ligand fishing technique	41
Prospective analytical role of sensors for environmental screening and monitoring	40
Microextraction techniques as versatile platforms for sample preparation of disinfection byproducts from aqueous media: Advances and challenges	40
Advances of surface-enhanced Raman spectroscopy in exosomal biomarkers analysis	40
Recent advances and applications of Bi2S3-based composites in photoelectrochemical sensors and biosensors	40
Reducing uncertainty and confronting ignorance about the potential impacts of microplastic on animals: A critical review	40
Review of miniaturized and portable optical emission spectrometry based on microplasma for elemental analysis	40
Current materials for miniaturized sample preparation: Recent advances and future trends	40
Recent advances in post-column derivatization: Enhancing sensitivity and selectivity in liquid chromatography analysis	40
Quantification and mapping of RNA modifications	40
Human exposure to micro(nano)plastics: Health risks and analysis methods	40
Deep eutectic solvents-modified advanced functional materials for pollutant detection in food and the environment	40
Recent advances in technologies toward the development of 2D materials-based electronic noses	40
Detection, characterization and imaging of micro- and nanoparticles in biotic tissues by laser-induced breakdown spectroscopy	40
A review on environmental isotope analysis of aquatic micropollutants: Recent advances, pitfalls and perspectives	39
Micro/nanofluidic-electrochemical biosensors for in situ tumor cell analysis	39
The application of coffee-ring effect in analytical chemistry	39
Calibration methods in qualitative analysis	39
Distance-based detection in analytical flow devices: From gas detection tubes to microfluidic chips and microfluidic paper-based analytical devices	39
Enzyme-catalyzed molecular MR imaging of tumors	39
The role of oxylipins and their validation as biomarkers in the clinical context	39
Contribution of supercritical fluid chromatography to serially coupling columns for chiral and achiral separations	39
Gold nanoparticles conjugated with fluorophore-labeled DNA: Overview of sensing and imaging applications	39
Dual/Multi-responsive fluorogenic probes for multiple analytes in mitochondria: From design to applications	38
Recent advances of upconversion nanoparticles-based lateral flow assays for point-of-care testing	38
Recent advances in data-mining techniques for measuring transformation products by high-resolution mass spectrometry	38
Protein-mediated fluorescent probes for bioimaging and biosensing: From fundamentals to applications	38
Reticular sensing materials with aggregation-induced emission characteristics	38
Seeing the invisible: Preparative strategies to visualise elusive molecules using mass spectrometry imaging	38
Toxic effects of micro(nano)-plastics on terrestrial ecosystems and human health	38
Recent advances in laser-induced breakdown spectroscopy quantification: From fundamental understanding to data processing	38
Advanced on-site and in vitro signal amplification biosensors for biomolecule analysis	38
CRISPR techniques and potential for the detection and discrimination of SARS-CoV-2 variants of concern	38
Pressurized liquid extraction for the determination of bioactive compounds in plants with emphasis on phenolics	37
Polymers modified porous silicon optical (bio)sensors	37
Mass spectrometry detection of environmental microplastics: Advances and challenges	37