TRAC-Trends in Analytical Chemistry

Article	Citations
Editorial Board	485
Editorial Board	308
Unique role of molecular imaging probes for viral infection	214
Toxicity mechanisms and alleviation strategies of micro/nanoplastics to animals: A review	211
High resolution single-cell transcriptomics towards precision profiling across multi-omics and spatial dimensions	202
Advancing cancer diagnosis through surface plasmon resonance detection of extracellular vesicles	198
Next-generation point-of-care diagnostics for cervical cancer: Integrating programmable biorecognition, nanomaterials, and artificial intelligence	197
Micro- and nanoscale sensing of volatile organic compounds for early-stage cancer diagnosis	193
Advances and challenges in the selective extraction of low molecular weight carbohydrates using ionic liquids and deep eutectic solvents	187
From exogenous to endogenous: Advances in in vivo sampling in living systems	182
Compositions, sensing mechanisms, and analytical development of infinite coordination polymers in monitoring trace-level pollutants	175
On the road to automation: a comparative review on chemometric strategies for GC-MS data analysis	173
3D printed microfluidics for cell biological applications	172
Multidimensional single-cell analysis: Diverse strategies and emerging applications in the life sciences	169
Design strategies and applications of responsive metal-based luminescence probes in the bioanalysis	162
CRISPR/Cas system for real-time water quality monitoring: Advances and challenges	151
Single-molecule detection-based super-resolution imaging in single-cell analysis: Inspiring progress and future prospects	150
Greenness of analytical methods for the study of metal-containing nanoparticles in biomedical samples, personal care products and food	145
Preface to the special issue: Chemometrics	145
Technical constraints in translating paper-based CRISPR/Cas assays to wearable formats	142
Galectins detection for the diagnosis of chronic diseases: An emerging biosensor approach	141
Empowering Traditional Chinese Medicine with artificial intelligence: Innovations in quality control, therapeutic applications, and industrialization	139
Recent advances in ion mobility instrumentation for targeted analysis	138
Mapping micro(nano)plastics in various organ systems: Their emerging links to human diseases?	137
Genetically encoded fluorescent neurotransmitter sensors: A new frontier in molecular diagnostics and real-time brain imaging	134

Concomitant presence of nanosized plastics and metal(loid)s: is there cause for alarm? State-of-the-art and recommendations for future studies	131
Playing with biological selectivity: Antimicrobial peptides and bacteriophages-based optical biosensors for pathogenic bacteria detection	131
Optical biosensors utilising viral receptors ACE2 and ACE2 mimics	126
Single-cell spatial (scs) omics: Recent developments in data analysis	124
High-end ion mobility mass spectrometry: A current review of analytical capacity in omics applications and structural investigations	123
Microscale thermophoresis (MST) and spectral shift (SpS) in drug discovery	123
Advances in optical devices for the detection of contaminants in food and water	122
Electrochemical sensing of human hormones	121
Field-effect transistor biosensors for monitoring cellular physiological activities: A comprehensive review	121
High-resolution mass spectrometry strategies for profiling fluorinated pesticides and their transformation products in environmental matrices	119
Advances in interferometric sensors for the detection of food contaminants	117
Current issues and perspectives in nanosensors-based artificial olfactory systems for breath diagnostics and environmental exposure monitoring	113
Synthesis strategies to bring molecularly imprinted polymers closer to applications	112
Emergent analytical strategies and tools to track functional inorganic nanomaterials applied for sustainable agriculture	112
Novel developments in capillary electrophoresis miniaturization, sampling, detection and portability: An overview of the last decade	112
Applications of thread-based microfluidics: Approaches and options for detection	110
Molecularly imprinted polymer-modified carbon paste electrodes (MIP-CPE): A review on sensitive electrochemical sensors for pharmaceutical determinations	109
Recent advances in metal–organic frameworks as emerging platforms for immunoassays	109
Application of machine learning to improve the accuracy of electrochemical sensors: A review	109
Recent advances in flexible sensors: From sensing materials to detection modes	108
CRISPR-Cas assisted diagnostics: A broad application biosensing approach	105
Recent developments and future perspectives of chiral liquid chromatography for food safety and quality	104
Sustainable sorbents for dispersive solid-phase extraction in environmental analysis	104
Detection and impact assessment of polylactic acid microplastics in aquatic and sediment systems: Advances in analytical techniques	103
Overview of recent advances of Raman spectroscopy in molecular medicine	102
A comprehensive review on ecological effects of microplastic pollution: An interaction with pollutants in the ecosystems and future perspectives	102
Nanofibers prepared from synthetic polymers and biopolymers as advanced extraction materials for sample preparation prior to liquid chromatography	102
High-throughput mass spectrometry imaging of biological systems: Current approaches and future directions	101
Advance on the sample preparation and analytical methods for water disinfection byproducts	100
Recent advancements in biosensors for diagnosis of ovarian cancer: Analytical approaches	100
Advancements in detection techniques for per- and polyfluoroalkyl substances: A comprehensive review	100
Hydroxyapatite-based composites as efficient sorbents: Fabrication and application in sample preparation techniques	99
Advancements in magnetic aptasensors: Recent progress and future trends in biosensor technology	99
Advances in imaging techniques for real-time microbial visualization in wastewater treatment reactors: Challenges, applications, and process optimization	98
Microneedle wearables in advanced microsystems: Unlocking next-generation biosensing with AI	98
Analytical and biomedical applications of microfluidics in traditional Chinese medicine research	97
Applications of nanomaterial-based chemiluminescence sensors in environmental analysis	97
Optical microscopic and spectroscopic detection of exosomes	96
Smart materials as modifiers of capillary electromigration methods in bioanalysis	95
Fluorogenic toolbox for visualizing protein aggregation: From designing principles to biological application	94
Hydrogel sorbent-based sample preparation processes as green alternatives for the extraction of organic contaminants followed by chromatographic analysis	94
Novel sorptive extraction techniques in bioanalysis evaluated by Blue Applicability Grade Index: The paradigm of fabric phase sorptive extraction and capsule phase microextraction	94
Flow-based automated systems coupled with luminescence detection for non-metal determination: A comprehensive review from 2000 till present	94
Single-molecule microscopy for precision medicine and diagnostics	93
Analytical methods for biomonitoring organic chemical hazards in saliva: A systematic review	92
Recent advances towards the use of deep eutectic solvents and cyclodextrins in the extraction of food contaminants: From traditional sample pretreatment techniques to green microextraction and beyond	92
Covalent organic frameworks for next-generation biomedicine: from rational design to multimodal theranostics	91
Recent chemical mixing devices for time-resolved serial femtosecond crystallography	91
Fluorescent sensors for anthelmintic drug detection: Advances in materials, mechanisms, and analytical applications	90
Synergizing Machine Learning and fluorescent biomolecules: A new era in sensing platforms	90

Potential applications and challenges of novel ambient ionization mass spectrometric techniques in the emergency care for acute poisoning	89
Rediscovering similarity analysis of analytical signal: A not well-known mainstay of chemometrics	89
Nanomaterial-based chemiluminescence systems for tracing of reactive oxygen species in biosensors	88
A critical review of acrylamide green extraction and determination in food matrices: Current insights and future perspectives	88
Probing protein higher-order structures by native capillary electrophoresis-mass spectrometry	87
Recent advances in electrochemical sensing of cocaine: A review	87
Tracing per- and polyfluoroalkyl substances (PFASs) in the aquatic environment: Target analysis and beyond	87
Exhaled volatile organic compounds and respiratory disease: Recent progress and future outlook	86
Deciphering the research of Micro(nano)plastics: An in-depth bibliometric expedition into ecotoxicological impacts and research trends	86
Advances in protein sequencing: Techniques, challenges and prospects	86
Neonatal point-of-care testing	86
Evolution in understandings of the design, optimization, and application of sorbent-based extraction devices	86
Cellulose immobilization strategies for paper-based immunoassays	85
The highest yield, or greener solvents? Latest trends in quercetin extraction methods	84
The multipurpose application of resazurin in micro-analytical techniques: Trends from the microbial, catalysis and single molecule detection assays	84
Trends in electrochemical nanosensors for the analysis of antioxidants	84
Advances in analytical technologies detecting and characterizing noncovalent interactions for fragment-based drug discovery	83
State of the art and perspectives of improving antibody performance in food immunosensors	82
Merging microfluidics with luminescence immunoassays for urgent point-of-care diagnostics of COVID-19	82
Molecular recognition-driven detection of β-Lactoglobulin: Mechanisms, progress and future prospects	81
Fluorescent nanozymes: Emerging versatile materials advancing analytical chemistry	81
MXene-based composites: A new generation material for the sample preparation and pre-concentration of the traces of organic species in environmental samples: A comprehensive review	81
Advancement in exosome isolation and label-free detection towards clinical diagnosis	80
Analytical performance of electrochemical surface-enhanced Raman spectroscopy: A critical review	80
Emerging single-cell microfluidic technology for microbiology	80
Recent advances on graphene and graphene oxide as extraction materials in solid-phase (micro)extraction	80
Microfluidics for chiral separation of biomolecules	79
Innovative nanozyme-based detection methods for biomarkers in interstitial fluid	79
Recent advances in single-entity electrochemistry for metal nanoparticle, nanodroplet, and bio-entity analysis	78
Recent advances in centrifugal microfluidic chip-based loop-mediated isothermal amplification	78
Recent developments in sample pretreatment techniques for the determination of fluoroquinolones in foods	78
On-site screening from portability to intelligence: Molecularly imprinted sensors for rapid early warning of mycotoxins	77
Direct RNA modification mapping: Technological advances, gaps, and emerging trends	77
Critical review of analytical methods for antifouling paint particles in marine systems	76
Recent developments of small-molecule fluorescent probes for the detection of hydroxyl radical in biological systems	76
Ion mobility Mass Spectrometry for Glycomics: Challenges and Opportunities When Met with Artificial Intelligence	76
Comprehensive approaches to expanding CRISPR biosensor applications beyond nucleic acid targets	75
Applications of metal organic frameworks in point of care testing	75
Microplastic aging processes: Environmental relevance and analytical implications	74
Machine learning-assisted carbon dots synthesis and analysis: State of the art and future directions	74
Towards clinical application: Emerging strategies for ultrasensitive and selective miRNA detection	74
Boosting comprehensive two-dimensional chromatography with artificial intelligence: Application to food-omics	74
Recent trends and advancements in electrochemiluminescence biosensors for human virus detection	74
Recent advancements in polyaniline-based biosensors for diagnosis of cancers: A comprehensive review	74
Editorial Board	73
Advancements of multiple template-based molecularly imprinted polymers (mt-MIPs) in deep eutectic solvents (DESs): Towards greener imprinting approaches	73
Rapid in-situ synthesis of metal organic frameworks for biosensors	72
Recent advancements in dual modality biosensors for detecting disease causing pathogens	72
Advances in single extracellular vesicle characterization and multiplexed profiling	72
Recent progress and challenges in biosensing of carcinoembryonic antigen	72
Aptamer-based electrochemical biosensors for the breast cancer biomarkers: Developments, challenges, and future directions	72
Nanopore sensing: current progress and future challenges tackled by nanofluidic devices	71
Application of chemometrics and related advanced data handling in chemical separations	71
Analytical frontiers in disinfection byproducts research: Linking formation, transformation, and antibiotic resistance through advanced mass spectrometry, isotopic, and sensing tools	71
Capillary electrophoresis and Raman: Can we ever expect light at the end of the tunnel?	70
Fate and impact of nanoplastics in the human digestive environment after oral exposure: A common challenge for toxicology and chemistry	69
Development of biomimetic phospholipid membrane chromatography for drug discovery: A comprehensive review	69
Corrigendum to “Combining chemometrics and paper-based analytical devices for sensing: An overview” [TrAC. Trends Anal. Chem. 164 (2023) 117091]	69
Trends in melatonin sensing technology for biomedical applications:Precision sleep medicine and beyond	69
Advances in X-ray neuroimaging: Bridging scales from molecular to organ architectures	68
Advances in mass spectrometry-based strategies for analyzing sialic acid linkage isomers	68
Green photonic biosensing: Approaching sustainability in point-of-care diagnostics	68
Advances in detection technologies for RNA m6A modifications and related enzymes: Strategies and applications	68
Magnetic-based microextraction systems for the determination of emerging contaminants in environmental liquid samples	67
Recent trends in analytical measures of microplastic in soil and toxicopathological risk assessment in earthworms	67
Recent advances in separation methods for characterization of glutathione metabolism and dietary supplementation	67
Microplastics in soil aggregates: Analytical methods, occurrence patterns, impact analyses and removal approaches	67
Advances in gas pressure-based portable biosensing	67
Enantioselective separation techniques in forensic analysis and clinical toxicology	67
The interdiscipline rendezvous of aptamers and radionuclides: Advances, challenges and prospects	67
3D printed microfluidics for bioanalysis: A review of recent advancements and applications	67
Towards a harmonized identification scoring system in LC-HRMS/MS based non-target screening (NTS) of emerging contaminants	66
Early-diagnosis of major depressive disorder: From biomarkers to point-of-care testing	66
Recent progress in microfluidic biosensors with different driving forces	66
Split technology in CRISPR-Cas system for precision genome manipulation and diagnostics	65
Determination and assessment of contamination of toxic chemical elements in soils – Review	65
Sample preparation and mass spectrometry for determining mycotoxins, hazardous fungi, and their metabolites in the environment, food, and healthcare	65
Recent advance in nucleic acid amplification-based surface-enhanced Raman scattering for in vitro and in vivo biosensing	65
The aerobiological pathway of natural respiratory viral aerosols	65
Sensitive enzyme-free electrochemical sensors for the detection of pesticide residues in food and water	65

Analytical approaches for detecting biocides in aquatic environments: Advances and challenges	65
Recent advances in nano/microfabricated substrate platforms and artificial intelligence for practical surface-enhanced Raman scattering-based bioanalysis	65
Advances in small organic molecule fluorescent probes for formaldehyde detection and imaging in pathophysiological processes: A comprehensive review	65
Recent advances of aptamer based sensors for aflatoxins	64
Will data analytics revolution finally bring SERS to the clinic?	64
Recent advances in droplet microfluidics for single-cell analysis	64
Organ-on-a-chip platforms integrated with biosensors for precise monitoring of the cells and cellular microenvironment	64
Recent advances in metal/covalent organic framework-based materials for photoelectrochemical sensing applications	63
Transient OCP-apatite epitaxy controls bone mineralization. An X-ray total scattering study	63
Microplastics and nanoplastics in food, water, and beverages; part I. occurrence	63
Editorial Board	63
Towards a rational and efficient risk assessment for microplastics	63
Membrane inlet mass spectrometry (MIMS) for analysis of water disinfection byproducts: Recent advances	62
Polymer inclusion membranes based Optode: Recent advances and perspectives	62
Corrigendum to “Molecularly imprinted polymers for the detection of volatile biomarkers” [Trends Anal. Chem. 177 (2024) 117783]	62
Surface molecularly imprinted polymer nanocatalytic probes for scattering spectral analysis	62
Editorial Board	62
Surface-enhanced Raman spectroscopy in the monitoring of drug concentrations in blood	61
Deep eutectic solvents for microextraction of endocrine disruptor contaminants from water and food: Review	61
Synthesis and characterization of TiO2 nanomaterials for sensing environmental volatile compounds (VOCs): A review	61
Caenorhabditis elegans (C. elegans) sample preparation for metabolomics and lipidomics analysis – A review	61
Intelligent terahertz data analysis in agriculture: A systematic review of AI-driven approaches	61
Minimalist nanobody architecture: A double-edged sword for immunological analysis	61
Trends in nucleic acids and non-nucleic acids nanostructures-enhanced site-specific DNA methylation biosensing	61
Modern sorbent-based sample preparation methods for the determination of analytes of forensic interest: A dual-tool approach for evaluation of greenness and practical utility	61
Evolution and impact of Smart Analytical Chemistry in non-destructive spectroscopy for food applications	61
Recent developments of ECL mechanisms study and their applications	60
Miniaturized solid phase extraction techniques for different kind of pollutants analysis: State of the art and future perspectives – PART 2	60
A review of organic aerosol speciation by comprehensive two-dimensional gas chromatography	60
The twelve goals of circular analytical chemistry	59
Untargeted chromatographic methods coupled with chemometric strategies for the analysis of food and related samples	59
Real-time on-body sweat sensing: Electrochemical insights, progress, and prospects	59
Recent advances in microfluidic devices for foodborne pathogens detection	59
Recent advances of chiral metal-organic frameworks in analytic chemistry	58
Dual-target fluorescence probes: A new frontier in cardiovascular disease diagnosis	58
Portable sensors in precision agriculture: Assessing advances and challenges in soil nutrient determination	58
Recent advances in organelle-specific two-photon small-molecule fluorescent probes for bioanalysis in live tissues	58
Recent progress in molecular diagnostics: The synergy of rolling circle amplification and CRISPR/Cas systems (2018–2024) – A concise review	58
Raman scattering applied to human breath analysis	58
Advances in solid-phase microextraction for detecting endocrine disrupting compounds in environmental and biological matrices	57
Sample preparation of polar metabolites in biological samples: Methodologies and technological insights	57
Lateral flow assays for food analyses: Food contaminants, allergens, toxins, and beyond	57
Capillary isoelectric focusing – The role of markers of isoelectric point and recent applications in the field	57
Advances in 3D printed sensors for food analysis	57
Current trends of unsustainable plastic production and micro(nano)plastic pollution	57
Exploiting the penetration depth of XRF and NIR radiation: from 2D to 3D spectral imaging	57
Development of laser-induced breakdown spectroscopy based spectral tandem technology: A topical review	57
Dimension-Controlled Nanomaterial-Based Electrochemical Biosensors for the Detection of Pathogenic Bacteria and Related Biomarkers	56
Modern automated sample preparation for the determination of organic compounds: A review on robotic and on-flow systems	56
CRISPR biosensing with lateral flow assays for point of care Diagnostics: Overcoming commercial development challenges	56
Recent advancements in nucleic acid detection with microfluidic chip for molecular diagnostics	56
Portable X-ray fluorescence (pXRF) as a powerful and trending analytical tool for in situ food samples analysis: A comprehensive review of application - State of the art	56
Recent advances of cellulose nanofiber-based materials in cell culture: From population to single-cell	55
Tracking indoor volatile organic compounds with online mass spectrometry	55
Editorial Board	55
Cutting-edge MoS2-Based biosensing platforms for detecting contaminants in food samples	55
Ultrasound-assisted microextraction: Advancements, applications, and future directions in analytical chemistry	55
Corrigendum to “Offline preparative separation methods based on electromigration: An overview and current trends” [Trac. Trends Anal. Chem. 170 (2023) 117428]	55
Editorial Board	55
Radiometric strategy to track nanopesticides: An important approach to understand the fate, mechanisms of action and toxicity	55
Multi-scenario deployable analysis platform for the detection of illicit pharmaceutical adulteration in dietary supplements	55
Variable electric field and atomic percentage of doping on the displacement process of C20 molecules in a nanotube with molecular dynamics simulation	55
Editorial Board	54
Lights and shadows of mass spectrometry-based metabolomics studies in cancer diagnosis: is there any marker beyond the literature background noise?	54
Recent advances in the analytical applications of laccase-like nanozymes	54
Biosensing based on lossy mode resonances	54
Plasmonic biosensors: Towards fully operative detection platforms for biomedical application and its potential for the diagnosis of autoimmune diseases	54
Laser-scribed micro/nanostructures modified surfaces for electrochemical sensors: From fundamentals to applications	54
Gas–phase sampling and preconcentration of nerve agents: Overview of thermally desorbable materials used	54
Recent advances in microfluidic single-cell analysis and its applications in drug development	54
Forensic drug screening by liquid chromatography hyphenated with high-resolution mass spectrometry (LC-HRMS)	53
Assessing the availability of trace metals including rare earth elements in deep ocean waters of the Clarion Clipperton Zone, NE Pacific: Application of an in situ DGT passive sampling method	53
From confinement to quantum tunnelling: Redox cycling electrochemistry across scales for ultra-sensitive molecular sensing	53
Fluorescent probes based on bioorthogonal reactions: Construction strategies and applications	53
Recent advances in technologies toward the development of 2D materials-based electronic noses	53
Thermal shift assay for protein–ligand dissociation constant determination	53
MOFs/COFs-based hybrids for agricultural sensors: Current state of art and beyond	53
Polar organic pollutants, micro-nano plastics and nanomaterials: Analytical techniques to reveal the still invisible human physico-chemical exposome	53
Uric acid biosensors based on molecular recognition: Classifications, advances, and prospects	53
Advanced nucleic acid probes for enhanced CRISPR diagnostics	53
Recent progress of gas sensors based on metal oxide composites derived from bimetallic metal-organic frameworks	53
Recent advances in microfluidic sensors for nutrients detection in water	52
State-of-the-art application of mass spectrometry imaging covering the medicinal and edible plants	52
Challenges and opportunities in the development of planar potentiometric sensors for point-of-care analysis	52
Emerging trends in green carbon dots coated with molecularly imprinted polymers for sensor platforms	52
Intelligent nanosensors towards pathogenic bacteria and their derivatives for infectious disease diagnosis	51
CRISPR/Cas12a-based biosensors for foodborne mycotoxin detection: A review of current technologies and future prospects	51
Versatile sensing strategies based on emerging programmable prokaryotic Argonautes: From nucleic acid to non-nucleic acid targets	51
Plastic problem solved? Environmental implications of synthetic hydrophilic polymers across ecosystem boundaries	51
Updated overview of QuEChERS applications in food, environmental and biological analysis (2020–2023)	50
Cutting-edge progress in carbon nanomaterial-functionalized silver nanoparticles for enhanced optical and electrochemical sensing applications	50
Recent advances in exhaled breath sample preparation technologies for drug of abuse detection	50
Update of high-intensity ultrasound applications for the extraction of pectin from agri-food by-products	50
AI-enhanced CRISPR diagnostics: From gRNA design to Cas protein engineering and signal analytics	50
Analysis of contaminants of environment and foods by capillary electromigration techniques	50