TRAC-Trends in Analytical Chemistry

Article	Citations
Recent developments and future perspectives of chiral liquid chromatography for food safety and quality	501
Microscale thermophoresis (MST) and spectral shift (SpS) in drug discovery	449
Recent advances on nanomaterials for personalized diagnostics in multiplex point-of-care testing	363
Electrochemical biosensing interfaced with cell-free synthetic biology	181
Surveying analytical techniques for a comprehensive analysis of airborne particulate samples in museum environments	148
Rapid enzymatic assays for fecal contamination in aquatic environment: Challenges, advances and prospects	148
Editorial Board	127
Recent progress and advancement in detecting Methylmercury using a battery of biosensors and biomolecular-based techniques: An updated overview	125
Recent developments in electrochemical sensors and biosensors for food additives determination: Principle and application	119
Mapping micro(nano)plastics in various organ systems: Their emerging links to human diseases?	118
Recent advancements in biosensors for diagnosis of ovarian cancer: Analytical approaches	117
Single-cell spatial (scs) omics: Recent developments in data analysis	116
Multidimensional single-cell analysis: Diverse strategies and emerging applications in the life sciences	109
Isotropic imaging-based contactless manipulation for single-cell spatial heterogeneity analysis	108
Gel electro-membrane extraction: An overview on recent strategies for extraction efficiency enhancement	105
White analytical chemistry approaches for analytical and bioanalytical techniques: Applications and challenges	104
Advanced analytical and informatic strategies for metabolite annotation in untargeted metabolomics	104
Text mining and computational chemistry reveal trends in applications and applicability of capillary electrophoresis	103
Recent advances in the analysis of plastic migrants in food	101
High-throughput optical assays for sensing serine hydrolases in living systems and their applications	101
ML-based clinical decision support models based on metabolomics data	100
Advanced technologies for screening and identifying covalent inhibitors	99
Metal-organic frameworks (MOFs) and covalent organic frameworks (COFs)-based prototyping of integrated sensing devices for robust analysis	98
Advance on the sample preparation and analytical methods for water disinfection byproducts	97
Recent progress of molecular fluorescent probes with multi-recognition sites enable sensitive and selective analysis	96

Native mass spectrometry for characterization of proteins binding with small molecules and application in drug discovery	95
Lipid droplet-targeting optical biosensors: Design strategies and applications	93
Challenges and recommendations in experimentation and risk assessment of nanoplastics in aquatic organisms	92
Raman biosensor and molecular tools for integrated monitoring of pathogens and antimicrobial resistance in wastewater	92
From exogenous to endogenous: Advances in in vivo sampling in living systems	92
Distance-based microfluidic assays for instrument-free visual point-of-care testing	91
Concomitant presence of nanosized plastics and metal(loid)s: is there cause for alarm? State-of-the-art and recommendations for future studies	91
Microfluidics add-on technologies for single-cell analysis	89
Single-molecule detection-based super-resolution imaging in single-cell analysis: Inspiring progress and future prospects	89
Analyses of chemical components and their functions in single species plant-derived exosome like vesicle	89
Electrochemically measuring metabolic activity of single live microbes	86
Tailored diagnostic tool for exosome detection utilizing DNA-based nanostructures	85
Design strategies and applications of responsive metal-based luminescence probes in the bioanalysis	84
Recent advances in plant insect monitoring using volatile profiling strategy	84
Immunological tests: Essential and supportive tools in the fight against COVID-19	82
Formaldehyde in biological systems: Involving sources, related diseases and reaction-based fluorescent detection	82
Probing the dynamic crosstalk of lysosomes and mitochondria with structured illumination microscopy	80
Derivatization strategies for the determination of histamine in food samples: A review of recent separation-based methods	80
Silicon-based nanoparticles: Synthesis and recent applications in chemical sensing	80
Advancements in magnetic aptasensors: Recent progress and future trends in biosensor technology	79
Comprehensive greenness evaluation of the reported chromatographic methods for aldehydes determination as clinical biomarkers and food quality indicators	79
Electroanalytical systems based on solid-state nanochannel arrays for the detection of biomarkers of interest in clinical diagnostics	79
Micro- and nanoscale sensing of volatile organic compounds for early-stage cancer diagnosis	77
Insights into highly multiplexed tissue images: A primer for Mass Cytometry Imaging data analysis	77
Editorial Board	76
Editorial Board	76
Editorial Board	76
Mass tag-based mass spectrometric immunoassay and its bioanalysis applications	75
Editorial	75
Technology development trend of electrospray ionization mass spectrometry for single-cell proteomics	74
Editorial Board	74
In vitro immunotoxicity detection for environmental pollutants: Current techniques and future perspectives	74
Mass spectrometry for mitochondrial multi-omics	74
Discovery and translation of functional nucleic acids for clinically diagnosing infectious diseases: Opportunities and challenges	73
Quantitative challenges and their bioinformatic solutions in mass spectrometry-based metabolomics	73
On-site and in-vivo strategies for instrument and method development, a sustainable alternative for the new generation of analytical chemists	71
Multiscale micro-/nanofluidic devices incorporating self-assembled particle membranes for bioanalysis: A review	70
Recent advances in nanomaterials based biosensors for point of care (PoC) diagnosis of Covid-19 – A minireview	70
Mass spectrometry analytical responses to the SARS-CoV2 coronavirus in review	70
Screening of specific binding peptides using phage-display techniques and their biosensing applications	70
Exhaled breath analysis of non-volatile drugs: Towards clinical applications	70
Recent progress in wearable extractive sampling technology	69
Applications of synchrotron powder X-ray diffractometry in drug substance and drug product characterization	69
Extending the potential of Fourier transform ion cyclotron resonance mass spectrometry for the analysis of disinfection by-products	68
Recent advances and current trends in optical fiber biosensors based on tilted fiber Bragg gratings	68
Rapid methods for antimicrobial resistance diagnosis in contaminated soils for effective remediation strategy	68
Advances in the recognition strategies and analytical techniques of bile acids	68
Analytical and biomedical applications of microfluidics in traditional Chinese medicine research	68
Nanofibers prepared from synthetic polymers and biopolymers as advanced extraction materials for sample preparation prior to liquid chromatography	67
Trends in organ-on-a-chip for pharmacological analysis	67

Recent trends in the use of silica-based materials and their composites in extraction techniques: A review	66
Long period fiber grating-based biosensing: Recent trends and future perspectives	66
Recent advances and typical applications in mass spectrometry-based technologies for single-cell metabolite analysis	65
Innovative horizons in cancer therapy, imaging, and sensing with Janus nanoparticles: A comprehensive review	65
Recent developments toward microfluidic point-of-care diagnostic sensors for viral infections	65
Immobilized-enzyme reactors integrated into analytical platforms: Recent advances and challenges	65
New insights into extracellular vesicles of clinical and therapeutic interest using proteomic mass spectrometry approaches	65
Evaluating the whiteness of spectroscopy-based non-destructive analytical methods – Application to food analytical control	64
Performance of capillary electrophoresis instruments – State of the art and outlook	63
Recent advancements in techniques for analyzing modern, atypical antidepressants in complex biological matrices and their application in biomedical studies	63
Advancements in detection techniques for per- and polyfluoroalkyl substances: A comprehensive review	63
Recent approaches to the liquid chromatography-mass spectrometry analysis of modified deoxynucleosides as biomarkers in clinical research	62
Applications of scaffold-based advanced materials in biomedical sensing	62
Analytical aspects of sample handling during the quantification of selective serotonin reuptake inhibitors in clinical applications	62
Automated flow systems for total and isotopic analysis of uranium and thorium in samples of environmental interest – A review	61
Embracing lipidomics at single-cell resolution: Promises and pitfalls	60
Microscale immiscible phase magnetic processing for bioanalytical applications	60
State-of-the-art extraction and separation of enantiomers through the application of alternative solvents	60
3D printed microfluidics for cell biological applications	60
A perspective on enantioselective chromatography by comparing ultra-high performance supercritical fluid chromatography and normal-phase liquid chromatography through the use of a Pirkle-type stationa	59
Unique role of molecular imaging probes for viral infection	58
Metal-organic framework-based core-shell composites for chromatographic stationary phases	58
Recent development of noble metal-based bimetallic nanoparticles for colorimetric sensing	58
‘Old food, new methods’: recent developments in lipid analysis for ancient foodstuffs	58
Targeting out of range biomolecules: Chemical labeling strategies for qualitative and quantitative MALDI MS-based detection	57
Past, current, and future roles of 3D printing in the development of capillary electrophoresis systems	57
Novel developments in capillary electrophoresis miniaturization, sampling, detection and portability: An overview of the last decade	57
Enzyme-immobilized microfluidic devices for biomolecule detection	57
High-throughput mass spectrometry imaging of biological systems: Current approaches and future directions	57
Trends and challenges of nanotechnology in self-test at home	57
Ensuring food and water safety using magnetic mesoporous silica nanomaterials-based biosensors	55
A review of fraction collection technology for supercritical fluid chromatography	55
Recent advances in multifunctional nanomaterials enhanced immunochromatographic assays	54
Corrigendum to “Fluorescence detection setups in capillary electrophoresis and microscale liquid chromatography: Developments over the past decade” [Trends Anal. Chem. 181 (2024) 118001]	54
A review on recent advances of AI-integrated microfluidics for analytical and bioanalytical applications	54
Embarking on a journey through Micro-RNA and Circular-RNA detection methods	53
Magnetic particles-integrated CRISPR/Cas systems for biosensing	53
Solid supports and new advanced materials used in microextraction processes metal-organic framework-based solid-phase microextraction for air samples analysis: A mini-review	53
Fluorescent probes for the detection of alkaline phosphatase in biological systems: Recent advances and future prospects	53
Microplastic occurrences, transport, and quantification and associated effects on primary productivity and carbon cycling processes in freshwater ecosystems	53
Recent advances in flexible sensors: From sensing materials to detection modes	53
Design and synthesis of silica- and silicate-based materials, and their application in the development and analysis of latent fingerprints	53
Recent progress of responsive Raman scattering probes for biosensing and bioimaging	52
Laser trapping-Raman spectroscopy for characterizing single suspended atmospheric aerosols	52
A comprehensive review on recent advances in fluorescence-based bio-analytes sensing	52
Semiconductor photoelectroanalysis and photobioelectroanalysis: A perspective	52
Identification of biomarkers in wastewater-based epidemiology: Main approaches and analytical methods	51
Environmental problems and health risks with disposable baby diapers: Monitoring of toxic compounds by application of analytical techniques and need of education	51
Challenges and perspectives of CRISPR-based technology for diagnostic applications	51
Advances in interferometric sensors for the detection of food contaminants	51
Recent advances in optical sensors and probes for the detection of freshness in food samples: A comprehensive review (2020–2023)	50
Anthracycline antibiotics detection using turn-off luminescent nanosensors	50
Recent advances on nanomaterials-based photothermal sensing systems	50
Emerging synchrotron radiation X-ray-sensitive probes for in situ bioimaging at the nanoscale	49
Radionuclide-based Cerenkov luminescence in biomedicine: Current research progress and future perspectives	49
DNA-mediated growth of noble metal nanomaterials for biosensing applications	49
Paper-based devices for rapid diagnosis and wastewater surveillance	49
Advances and challenges in the selective extraction of low molecular weight carbohydrates using ionic liquids and deep eutectic solvents	49
Recent advances and prospects in on-site spectrophotometric nutrient measurement in aquatic ecosystems	48
(Re) thinking towards a sustainable analytical chemistry: Part I: Inorganic elemental sample treatment, and Part II: Alternative solvents and extraction techniques	48
Recent progress in CRISPR-based microfluidic assays and applications	48
Greenness of analytical methods for the study of metal-containing nanoparticles in biomedical samples, personal care products and food	48
Point-of-care COVID-19 diagnostics powered by lateral flow assay	47
Recent progress and applications of Raman spectrum denoising algorithms in chemical and biological analyses: A review	47
Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging	47
Mass spectrometry-based phosphoproteomics in clinical applications	47
On-line supercritical fluid extraction-supercritical fluid chromatography (SFE-SFC) at a glance: A coupling story	47
A comparative evaluation of analytical green metrics for microextraction techniques based on polymeric and gel membranes as solid support	47
Current advances in microplastic contamination in aquatic sediment: Analytical methods, global occurrence, and effects on elemental cycling	47
Molecularly imprinted polymers @ metal and covalent organic frameworks: From synthesis to application in analytical chemistry	47
Machine learning-assisted identification of environmental pollutants by liquid chromatography coupled with high-resolution mass spectrometry	47
Recent advances in protein biomarkers based enzymatic biosensors for non-communicable diseases	46
Insight into combined pollution of antibiotics and microplastics in aquatic and soil environment: Environmental behavior, interaction mechanism and associated impact of resistant genes	46
Analytical tools for antibody–drug conjugates: From in vitro to in vivo	46
High-end ion mobility mass spectrometry: A current review of analytical capacity in omics applications and structural investigations	46
Recent trends in two-dimensional liquid chromatography	46
Applications of thread-based microfluidics: Approaches and options for detection	46
Distribution, sources, transportation and biodegradation of microplastics in the soil environment	46
Strategies to remove templates from molecularly imprinted polymer (MIP) for biosensors	45
Progress, enhancement mechanisms and applications of electrochemiluminescence and photoluminescence metal nanoclusters	45

Optical fiber chemo and biosensors operating in the electrochemical domain – A review	45
Colorimetric biosensing assays based on gold nanoparticles functionalized/combined with non-antibody recognition elements	45
Recent advances in metal-organic framework-based nanozymes and their enabled optical biosensors for food safety analysis	45
Machine learning-assisted optical nano-sensor arrays in microorganism analysis	45
Biological uptake, distribution and toxicity of micro(nano)plastics in the aquatic biota: A special emphasis on size-dependent impacts	45
Catalytic hairpin assembly as cascade nucleic acid circuits for fluorescent biosensor: Design, evolution and application	45
Recent advances of artificial intelligence in quantitative analysis of food quality and safety indicators: A review	44
Applications of nanomaterial-based chemiluminescence sensors in environmental analysis	44
Recent advances in metal–organic frameworks as emerging platforms for immunoassays	44
Cannabis sativa bioactive compounds and their extraction, separation, purification, and identification technologies: An updated review	43
Voltammetric and amperometric applications of silver amalgam electrodes for monitoring of reducible organic compounds	43
CRISPR-Cas systems: From gene scissors to programmable biosensors	43
Recent advances in chromophore-assembled upconversion nanoprobes for chemo/biosensing	43
The state of art of nanocarbon black as analyte in a variety of matrices: A review	42
Photo/electro-catalytic degradation of micro- and nano-plastics by nanomaterials and corresponding degradation mechanism	42
Trends in pharmaceutical analysis and quality control by modern Raman spectroscopic techniques	42
Mass spectrometry for breath analysis	42
Biolayer interferometry and its applications in drug discovery and development	41
Aqueous two-phase systems for the extraction, separation, and recovery of synthetic dyes	41
Electrochemical sensors modified with ion-imprinted polymers for metal ion detection	41
Analytical micro and nano technologies meet sepsis diagnosis	41
Recent advances in cell membrane-coated technology for drug discovery from natural products	41
Optical biosensors for the detection of foodborne pathogens: recent development and future prospects	41
Optical biosensors utilising viral receptors ACE2 and ACE2 mimics	41
Current issues and perspectives in nanosensors-based artificial olfactory systems for breath diagnostics and environmental exposure monitoring	41
Direct solid-phase microextraction-mass spectrometry facilitates rapid analysis and green analytical chemistry	41
Interest of molecular networking in fundamental, clinical and forensic toxicology: A state-of-the-art review	41
Poly (amino acids) towards sensing: Recent progress and challenges	41
Playing with biological selectivity: Antimicrobial peptides and bacteriophages-based optical biosensors for pathogenic bacteria detection	40
Phosphorene and other layered pnictogens as a new source of 2D materials for electrochemical sensors	40
Recent progress in photoelectrochemical sensors to quantify pesticides in foods: Theory, photoactive substrate selection, recognition elements and applications	40
Application of artificial intelligence (AI)-enhanced biochemical sensing in molecular diagnosis and imaging analysis: Advancing and challenges	39
Ultrahigh-performance supercritical fluid chromatography / mass spectrometry in the lipidomic analysis	39
Current analytical methods to monitor type 2 diabetes medication in biological samples	39
Current development of wearable sensors based on nanosheets and applications	39
Opportunities and challenges of liquid chromatography coupled to supercritical fluid chromatography	38
Recent innovations in cloud point extraction towards a more efficient and environmentally friendly procedure	38
Chemical identification and differentiation of positional isomers of novel psychoactive substances – A comprehensive review	38
Deep eutectic solvents in liquid-phase microextraction: Contribution to green chemistry	38
Cancer biomarkers and their biosensors: A comprehensive review	38
Designing aptamer-enabled DNA polyhedra using paper origami	38
Review on molecularly imprinted polymers with a focus on their application to the analysis of protein biomarkers	38
Harnessing microfluidic technology for bacterial single-cell analysis in mammals	38
Galectins detection for the diagnosis of chronic diseases: An emerging biosensor approach	38
Metamorphosis of supercritical fluid chromatography: A viable tool for the analysis of polar compounds?	37
Recognition and analysis of biomarkers in tumor microenvironments based on promising molecular imprinting strategies with high selectivity	37
Microplastics in terrestrial ecosystems: Un-ignorable impacts on soil characterises, nutrient storage and its cycling	37
Plastic additives and microplastics as emerging contaminants: Mechanisms and analytical assessment	37
Quantum and carbon dots conjugated molecularly imprinted polymers as advanced nanomaterials for selective recognition of analytes in environmental, food and biomedical applications	37
Recent advances in microdroplet techniques for single-cell protein analysis	37
Overview of analytical methods for the determination of microplastics: Current status and trends	36
Understanding role of microstructures of nanomaterials in electrochemiluminescence properties and their applications	36
Organic additives in agricultural plastics and their impacts on soil ecosystems: Compared with conventional and biodegradable plastics	36
A not so circular healthcare economy: A review of challenges with plastic associated chemicals	36
CRISPR-Cas assisted diagnostics: A broad application biosensing approach	36
An updated overview of MOF@MIP in drug carrier and drug analysis: Construction, application and prospective	36
Recent advances in analytical methods of oxidative stress biomarkers induced by environmental pollutant exposure	36
Ultrasound-assisted extraction methods for the determination of organic contaminants in solid and liquid samples	35
Dispersive liquid-liquid microextraction: Evolution in design, application areas, and green aspects	35
CRISPR molecular detection techniques: Advances from single to multiple detection methods	35
Recent advances in carbon nanotube-based biosensors for biomolecular detection	35
Recent advancements in nanomaterials-based aptasensors for the detection of emerging contaminants in foodstuffs	35
In vivo solid phase microextraction for bioanalysis	35
Chitosan- and/or cellulose-based materials in analytical extraction processes: A review	34
Emerging tumor-on-chips with electrochemical biosensors	34
Perylene diimide-based chemosensors emerging in recent years: From design to sensing	34
Aptamer-functionalized metal organic frameworks as an emerging nanoprobe in the food safety field: Promising development opportunities and translational challenges	34
Recent trends in pharmaceutical analysis to foster modern drug discovery by comparative in-silico profiling of drugs and related substances	34
State of the art of the methods proposed for selenium speciation analysis by CVG-AFS	34
The recent advances in magnetic sorbents and their applications	33
Mass spectrometry based metabolomics of volume-restricted in-vivo brain samples: Actual status and the way forward	33
Sensorization of microfluidic brain-on-a-chip devices: Towards a new generation of integrated drug screening systems	33
Recent advances of covalent organic frameworks for solid-phase microextraction	33
Recent progress in metal-organic frameworks-based biosensors for pathogen detection	33
Data handling in data fusion: Methodologies and applications	33
Nanopore: Emerging for detecting protein post-translational modifications	33
Near-infrared-responsive photoelectrochemical biosensors	33
Advancements in biosensing of hormones: Recent progress and future trends	32
Trends in chemical sensors for non-invasive breath analysis	32
Fast-track synthesis of DNA-functionalized gold nanoparticles for biosensing applications	32
Exploring the potential of carbon quantum dots (CQDs) as an advanced nanomaterial for effective sensing and extraction of toxic pollutants	32
Nanozyme-enhanced paper-based biosensor technologies	32
Structural DNA tetrahedra and its electrochemical-related surface sensing	32
An overview of the key topics related to the study of tire particles and their chemical leachates: From problems to solutions	31
A critical review of biodegradable plastic mulch films in agriculture: Definitions, scientific background and potential impacts	31
Atypical deep eutectic solvents: New opportunities for chemical analysis	31
Recent advances in analytical sensing detection of heavy metal ions based on covalent organic frameworks nanocomposites	31
Catalytic hairpin self-assembly for biosensing: Classification, influencing factors, and applications	31
Small plastic fragments: A bridge between large plastic debris and micro- & nano-plastics	31
Migration testing of microplastics in plastic food-contact materials: Release, characterization, pollution level, and influencing factors	31
Multifarious biosensors for highly efficient bleomycin detection: Recent trends, different methods, and future directions	31
Molecularly imprinted polymer-modified carbon paste electrodes (MIP-CPE): A review on sensitive electrochemical sensors for pharmaceutical determinations	30
Laser-induced breakdown spectroscopy in cementitious materials: A chronological review of cement and concrete from the last 20 years	30
Novel materials for sorptive extraction techniques for the analysis of environmental water samples	30
Present status of microfluidic PCR chip in nucleic acid detection and future perspective	30