Trends in Pharmacological Sciences

Article	Citations
Subscription and Copyright Information	791
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Ensifentrine (Ohtuvayre™) for chronic obstructive pulmonary disease	354
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Advisory Board and Contents	180
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DOT1L: orchestrating methylation-dependent radiotheRAPy responses via BRCA1	152
Muscarinic receptors: from clinic to bench to clinic	146
Assembling the P450 puzzle: on the sources of nonadditivity in drug metabolism	142
Monitoring neurodegeneration through brain-derived extracellular vesicles in biofluids	131
Advancing chemical carcinogenicity prediction modeling: opportunities and challenges	126
Structural asymmetry in FGF23 signaling	119
Targeting complement in neurodegeneration: challenges, risks, and strategies	114
Swinging the SWI/SNF complexes for cancer therapy	112
Compstatins: the dawn of clinical C3-targeted complement inhibition	109
Structural pharmacology and mechanisms of GLP-1R signaling	104
Peptides as a therapeutic strategy against Klebsiella pneumoniae	103
Therapeutic inhibition of ferroptosis in neurodegenerative disease	96
Direct in vivo CAR T cell engineering	96
Shearing of surface mucin saps tumor cell strength	96
Advisory Board and Contents	94
Advisory Board and Contents	85
Chemically modified neoantigen-based immunotherapy for targeting KRASG12C-driven tumors	84
Phenotypic approaches for CNS drugs	80

Nemolizumab (Nemluvio®) for prurigo nodularis	78
Emerging strategies for beta cell transplantation to treat diabetes	78
Liquid–liquid phase separation: a principal organizer of the cell’s biochemical activity architecture	75
Ribosome-directed cancer therapies: the tip of the iceberg?	75
HSV-1 as a gene delivery platform for cancer gene therapy	70
A smart hospital-driven approach to precision pharmacovigilance	70
Advisory Board and Contents	68
A deep dive into degrader-induced protein-protein interfaces	67
Leveraging human microbiomes for disease prediction and treatment	66
Engineering ACE2 decoy receptors to combat viral escapability	66
Optogenetic engineering for precision cancer immunotherapy	66
Mechanistic considerations for adenosine-lidocaine-magnesium (ALM) in controlling coagulopathy	65
A perspective on psychedelic teratogenicity: the utility of zebrafish models	63
siRNA drug Leqvio (inclisiran) to lower cholesterol	62
Advisory Board and Contents	61
Genetically engineered loaded extracellular vesicles for drug delivery	61
Suzetrigine for moderate to severe acute pain	60
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Close to a year in TIPS’ saddle – I am optimistic	58
Thriving as members of under-represented groups in pharmacology-related careers	57
GPR35, ally of the anti-ischemic ATPIF1-ATP synthase interaction	54
Emerging approaches to induce immune tolerance to therapeutic proteins	53
Piezo1: structural pharmacology and mechanotransduction mechanisms	50
The structure, function, and pharmacology of MRGPRs	50
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Could dexmedetomidine be repurposed as a glymphatic enhancer?	49
Selective tyrosine kinase 2 inhibitors in inflammatory bowel disease	48
Alzheimer’s therapeutic development: shifting neurodegeneration to neuroregeneration	47
Mentoring future science leaders to thrive	47
Targeting AMPK as a potential treatment for hepatic fibrosis in MASLD	46
The promise of targeted protein degradation approaches	43
Lipoxygenases in chronic liver diseases: current insights and future perspectives	43
Advisory Board and Contents	43
Advancing non-destructive analysis of 3D printed medicines	43
Salt-inducible kinases: new players in pulmonary arterial hypertension?	42
Mavacamten improves symptoms in obstructive hypertrophic cardiomyopathy patients	42
Hepatic mitochondrial reductive stress in the pathogenesis and treatment of steatotic liver disease	42
The road less traveled: activating an oncogenic kinase	42
Targeting LKB1/STK11-mutant cancer: distinct metabolism, microenvironment, and therapeutic resistance	42
Inhalable neutralizing antibodies – promising approach to combating respiratory viral infections	41
Promising neuroimmune targets and drugs for CNS diseases	41
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Advisory Board and Contents	40
A novel function of the M2 muscarinic receptor	38
Monkeypox: potential vaccine development strategies	36
Protein acylations in cancer immunity: effects and therapeutic opportunities	36
The end of the beginning in understanding SLC22 polyspecificity	36
Frizzleds act as dynamic pharmacological entities	35
Targeting intracellular protein–protein interactions with macrocyclic peptides	35
Validation of agent-based models of surface receptor oligomerisation	35

Nanocarriers for oral delivery of biologics: small carriers for big payloads	35
BTK inhibitors: past, present, and future	32
Beyond G protein and arrestin: GRK2-biased β₂AR signaling	32
Advisory Board and Contents	32
Decoding pseudouridine: an emerging target for therapeutic development	32
Metabolic regulation in normal and leukemic stem cells	31
Circulating tumor cells in precision medicine: challenges and opportunities	30
Demographic diversity in platelet function and response to antiplatelet therapy	30
SEAKER cells coordinate cellular immunotherapy with localized chemotherapy	30
Histone lysine acetyltransferase inhibitors: an emerging class of drugs for cancer therapy	30
Eflornithine for treatment of high-risk neuroblastoma	29
Voltage-gated ion channels in epilepsies: circuit dysfunctions and treatments	29
Recent advances in generative biology for biotherapeutic discovery	29
Neurofilament light chain as a biomarker of chemotherapy-induced peripheral neuropathy	29
Development of PROTACs using computational approaches	28
Host-directed therapies for tuberculosis: quantitative systems pharmacology approaches	28
Engineered antibody fusion proteins for targeted disease therapy	28
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GPR35: from enigma to therapeutic target	28
Harnessing associative learning paradigms to optimize drug treatment	27
Magnesium for disease treatment and prevention: emerging mechanisms and opportunities	27
Tackling chronic kidney disease in diabetic patients with finerenone	27
Biologics and cardiac disease: challenges and opportunities	27
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High-power screening (HPS) empowered by DNA-encoded libraries	27
A novel anticancer pharmacological agent targeting mitochondrial complex I	27
Targeting plasma membrane cholesterol as a novel anticancer therapy	26
Neutrophil extracellular traps in wound healing	25
Targeting sensory neuron GPCRs for peripheral neuropathic pain	25
Oteseconazole (VIVOJA) for prevention of recurrent vulvovaginal candidiasis	25
Recent advancements in vaccine research and development	24
Boosting CAR-T cell therapy through vaccine synergy	24
Challenges and opportunities associated with rare-variant pharmacogenomics	24
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Modulation of Wnt–β-catenin signaling with antibodies: therapeutic opportunities and challenges	24
Crosstalk between androgen receptor and protein kinase G signaling in bone: implications for osteoporosis therapy	24
Visceral obesity and HFpEF: targets and therapeutic opportunities	24
Taming PRMT5–adaptor protein interactions	24
GABAA receptors as targets for treating affective and cognitive symptoms of depression	23
Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity	23
Circadian biology to advance therapeutics for mood disorders	23
Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics	22
Advisory Board and Contents	22
The ABCs of psychedelics: a preclinical roadmap for drug discovery	22
NLRP3 and pyroptosis blockers for treating inflammatory diseases	22
Harnessing UBR5 for targeted protein degradation of key transcriptional regulators	21
GPCR-dependent and -independent arrestin signaling	21
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Potential for targeting small heat shock protein modifications	21
The structure and function of YTHDF epitranscriptomic m6A readers	20
Advisory Board and Contents	20
Odorant receptors as potential drug targets	20
Targeted protein degrader development for cancer: advances, challenges, and opportunities	20
Glymphatic-stagnated edema induced by traumatic brain injury	20
Hans Jürg Schatzmann (1924–2021)	19
Advisory Board and Contents	19
Harnessing deep learning for enhanced ligand docking	18
KRASG12C/mTORC1 inhibition: a powerful duo in NSCLC therapeutics	18
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Bridging the gap in neuropsychiatric translational research	18
Thapsigargin: key to new host-directed coronavirus antivirals?	18
Malolactone strikes: K-Ras-G12D's Achilles' heel	17
Emerging epigenetic insights into aging mechanisms and interventions	17
Learning from natural design for local anesthetic delivery	17
Advancing small-molecule drug discovery by encoded dual-display technologies	17
Leveraging non-enzymatic functions of LSD1 for novel therapeutics	17
Glaucoma: neuroprotection with NAD-based therapeutic interventions	17
Mitochondrial dynamics proteins as emerging drug targets	16
Electroceuticals: emerging applications beyond the nervous system and excitable tissues	16
Celiac disease: mechanisms and emerging therapeutics	16
NET-targeted therapy: effects, limitations, and potential strategies to enhance treatment efficacy	16
Structural perspective of class B1 GPCR signaling	16
Advisory Board and Contents	15
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Apart, together: reflections on the COVID-19 pandemic	15
Advisory Board and Contents	15
Screening strategies for identifying RNA- and ribonucleoprotein-targeted compounds	15
Advisory Board and Contents	15
Advisory Board and Contents	15

Advisory Board and Contents	14
Current landscape of preclinical models of diabetic cardiomyopathy	14
Endometriosis: cannabidiol therapy for symptom relief	14
Subtyping for pancreatic cancer precision therapy	14
Safety of medicines and vaccines – building next generation capability	14
Reactive chemistry for covalent probe and therapeutic development	14
Human skin-on-a-chip for mpox pathogenesis studies and preclinical drug evaluation	14
Pharmacological targeting of the tumor–immune symbiosis in glioblastoma	14
Multiple hERG channel blocking pathways: implications for macromolecules	14
Isoform-selective targeting of PI3K: time to consider new opportunities?	14
Fluorescent RNAs: new opportunities for drug discovery	14
Targeting glycosylation to enhance tumor immunotherapy	14
Recent breakthroughs and future directions in drugging aquaporins	13
Targeting sialylation to treat central nervous system diseases	13
TNIK’s emerging role in cancer, metabolism, and age-related diseases	13
Targeting chromosomal instability and aneuploidy in cancer	13
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Engineering extracellular vesicles for diagnosis and therapy	13
Present and future of microglial pharmacology	13
Nanodelivery of cGAS-STING activators for tumor immunotherapy	13
Advances in spatial mass spectrometry enable in-depth neuropharmacodynamics	13
At last: the mitochondrial pyruvate carrier structure revealed!	13
A mechanism for ligand-dependent activation of AHR	13
Targeting galectin-3 in inflammatory and fibrotic diseases	13
Advisory Board and Contents	13
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Unifying mechanism behind the onset of acquired epilepsy	12
Advisory Board and Contents	12
Photoswitchable allosteric and dualsteric ligands in GPCR pharmacology	12
Advisory Board and Contents	12
IRAK4: potential therapeutic target for airway disease exacerbations	12
Paving the way for designing drugs targeting TMEM16A	12
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Calcitonin/PAC1 receptor splice variants: a blind spot in migraine research	11
Advisory Board and Contents	11
Casimersen for the treatment of Duchenne muscular dystrophy	11
In vivo functions of p75NTR: challenges and opportunities for an emerging therapeutic target	11
Copper homeostasis and cuproptosis in cardiovascular disease therapeutics	10
Mutations in muscle-type creatine kinase impact HIV prevention	10
Fezolinetant for menopausal hot flashes and night sweats	10
Pharmacological targets at the lysosomal autophagy–NLRP3 inflammasome crossroads	10
Heterobifunctional small molecules to modulate RNA function	10
Structural snapshot of a β-arrestin-biased receptor	10
Repurposing trifluoperazine for glioblastoma treatment	10
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Targeting in silico GPCR conformations with ultra-large library screening for hit discovery	10
18F-Flurpiridaz PET for imaging of myocardial ischemia	10
Giving ERK a jERK from the endosome	10
Therapeutic targeting of exportin-1 beyond nuclear export	10
Immune checkpoint blockade resistance in lung cancer: emerging mechanisms and therapeutic opportunities	10
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Current views on N-glycolylneuraminic acid in therapeutic recombinant proteins	9
A quick guide to networking for scientists	9
VMAT structures reveal exciting targets for drug development	8
The potential of long noncoding RNA therapies	8
The structure and function of olfactory receptors	8
Targeting neurological abnormalities in lysosomal storage diseases	8
Guanylate cyclase-C agonists as peripherally acting treatments of chronic visceral pain	8
Cholesterol – the devil you know; ceramide – the devil you don’t	8
Targeting TRPM channels for cerebral ischemia–reperfusion injury	8
PPAR agonists for the treatment of neuroinflammatory diseases	8
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Regulation of drug-metabolizing enzymes by sex-related hormones: clinical implications for transgender medicine	7
Data and AI-driven synthetic binding protein discovery	7
Differences in pathogenicity among the mpox virus clades: impact on drug discovery and vaccine development	7
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Gut-derived brain T cells modulate behavior via IFN-γ	7
Design and development of glucocorticoid receptor modulators	7
Emerging paradigms and recent progress in targeting ErbB in cancers	7
ACK1/TNK2 kinase: molecular mechanisms and emerging cancer therapeutics	7
Human carbonic anhydrase modulators: the past, present, and future	7
Hypothalamic AMPK as a possible target for energy balance-related diseases	6
PSA inhibitors for contraception: insights from prostate cancer	6
Potentiation of GPCR signaling by ATP and sugar monophosphates	6
Targeting Fks1 proteins for novel antifungal drug discovery	6
Some assembly required: a single-RNA vaccine against enterovirus-D68	6
Implications of innate immune sexual dimorphism for MASLD pathogenesis and treatment	6
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Advances in cell therapy: progress and challenges in hematological and solid tumors	6
Emerging mechanisms and therapeutics in inflammatory muscle diseases	6
A decoy mutant ACE2 designed to reduce COVID-19	5
Chromosome-scale genomes throw light on plant drug biosynthesis	5
Advisory Board and Contents	5
Shining light on parvalbumin interneuron plasticity	5
Emerging approaches for antagonizing the aryl hydrocarbon receptor	5
Targeting solute carriers to modulate receptor–ligand interactions	5
FOXO transcription factors as therapeutic targets in human diseases	5
The future of neuroimmunology research for CNS disease therapeutics	5
Advisory Board and Contents	5
Ganaxolone for management of seizures associated with CDKL5 deficiency disorder	5
Enhancing oncogenic signaling to kill cancer cells	5
Mitochondrial quality control mechanisms as therapeutic targets in doxorubicin-induced cardiotoxicity	5
Targeting mitochondrial dynamics and redox regulation in cardiovascular diseases	5
Efferocytosis in inflammatory bone disorders	5
Protein–protein interactions: developing small-molecule inhibitors/stabilizers through covalent strategies	5