Pharmacology & Therapeutics

Article	Citations
Tumor microenvironment as a therapeutic target in cancer	699
Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms	292
Idiopathic pulmonary fibrosis: Disease mechanisms and drug development	258
Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?	219
Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients	212
The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species	174
The birth of artemisinin	167
Resolution of inflammation: An organizing principle in biology and medicine	160
Advances in pathogenesis and therapeutic strategies for osteoporosis	156
Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression	150
Programming inflammatory cell death for therapy	121
Therapeutic targets in lung tissue remodelling and fibrosis	118
Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics	116
Pharmacological treatment of migraine: CGRP and 5-HT beyond the triptans	113
Natural medicine in neuroprotection for ischemic stroke: Challenges and prospective	113
Inflammation is a major regulator of drug metabolizing enzymes and transporters: Consequences for the personalization of drug treatment	110
The strategies and techniques of drug discovery from natural products	110
Carcinogenesis: Failure of resolution of inflammation?	107
Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint	104
Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential	101
Therapeutic potential of resveratrol against emerging respiratory viral infections	99
Targeting the NLRP3 inflammasome in cardiovascular diseases	98
Traditional application and modern pharmacological research of Artemisia annua L.	97
Physiologically-based pharmacokinetic models for children: Starting to reach maturation?	95
Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics	93

Bile acid metabolism and signaling, the microbiota, and metabolic disease	93
PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders	90
Drug repurposing for COVID-19: Approaches, challenges and promising candidates	89
The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy	88
Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders	87
Evidence-based pharmacological treatment options for ADHD in children and adolescents	87
Chinmedomics, a new strategy for evaluating the therapeutic efficacy of herbal medicines	84
Macrophage migration inhibitory factor (MIF): A multifaceted cytokine regulated by genetic and physiological strategies	81
Role of inflammatory chemokines in hypertension	80
Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms	79
Polyphenols and neuroprotection: Therapeutic implications for cognitive decline	78
Molecular mechanisms of ferroptosis and their involvement in brain diseases	75
Biased GPCR signaling: Possible mechanisms and inherent limitations	75
Mechano-therapeutics: Targeting Mechanical Signaling in Fibrosis and Tumor Stroma	74
The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention	74
The natriuretic peptide system in heart failure: Diagnostic and therapeutic implications	74
Kynurenine emerges from the shadows – Current knowledge on its fate and function	73
Current developments of targeting the p53 signaling pathway for cancer treatment	72
Triple negative breast cancer (TNBC): Non-genetic tumor heterogeneity and immune microenvironment: Emerging treatment options	71
Stepping forward in antibody-drug conjugate development	71
The Role of non-coding RNAs in colorectal cancer, with a focus on its autophagy	70
Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain	68
A decade of cell death studies: Breathing new life into necroptosis	68
Updates on community acquired pneumonia management in the ICU	68
Tumor organoid models in precision medicine and investigating cancer-stromal interactions	67
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle	66
Pharmacological treatment of eating disorders, comorbid mental health problems, malnutrition and physical health consequences	65
Sirtuins' control of autophagy and mitophagy in cancer	65
Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers	64
The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges	63
CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases	63
Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors	61
Targeting post-translational histone modifying enzymes in glioblastoma	61
G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects	59
Extracellular vesicles in cardiovascular disease: Biological functions and therapeutic implications	58
Double-edged roles of protein tyrosine phosphatase SHP2 in cancer and its inhibitors in clinical trials	58
Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications	57
Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases	57
Current and emerging therapies for Duchenne muscular dystrophy and spinal muscular atrophy	57
TGFβ-Directed Therapeutics: 2020	56
A deep dive into UV-based phototherapy: Mechanisms of action and emerging molecular targets in inflammation and cancer	55
Immune activities of polysaccharides isolated from Lycium barbarum L. What do we know so far?	55
Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing	53
Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression	53
Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19	53
Macrophage immunometabolism in inflammatory bowel diseases: From pathogenesis to therapy	53
Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system	52
Particulate matter air pollutants and cardiovascular disease: Strategies for intervention	52
Vasculogenic mimicry, a complex and devious process favoring tumorigenesis – Interest in making it a therapeutic target	52
MERTK in cancer therapy: Targeting the receptor tyrosine kinase in tumor cells and the immune system	52

Effects of local anesthetics on cancer cells	52
Advances in the research on the targets of anti-malaria actions of artemisinin	52
Genotoxic therapy and resistance mechanism in gliomas	52
Treatment of overdose in the synthetic opioid era	51
Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization	51
FGFR4: A promising therapeutic target for breast cancer and other solid tumors	51
New insights into molecular and cellular mechanisms of zoledronate in human osteosarcoma	51
Endothelial shear stress signal transduction and atherogenesis: From mechanisms to therapeutics	51
FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention	51
Novel strategies exploiting interleukin-12 in cancer immunotherapy	51
Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases	50
Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?	49
Blood-brain barrier leakage in Alzheimer’s disease: From discovery to clinical relevance	49
Prostate Cancer Biomarkers: From diagnosis to prognosis and precision-guided therapeutics	49
GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors	49
Metabolomics, metabolic flux analysis and cancer pharmacology	48
Evolving roles of lysyl oxidase family in tumorigenesis and cancer therapy	47
Clinical therapies and nano drug delivery systems for urinary bladder cancer	47
Molecular imaging of inflammation - Current and emerging technologies for diagnosis and treatment	47
Deliver the promise: RNAs as a new class of molecular entities for therapy and vaccination	47
Antimicrobial peptides – Unleashing their therapeutic potential using nanotechnology	47
Probiotics: Potential novel therapeutics for microbiota-gut-brain axis dysfunction across gender and lifespan	46
Review: RNA-based diagnostic markers discovery and therapeutic targets development in cancer	46
Regulation of organic anion transporters: Role in physiology, pathophysiology, and drug elimination	46
Toxicology of flavoring- and cannabis-containing e-liquids used in electronic delivery systems	46
Extracellular vesicles in cancer diagnostics and therapeutics	44
New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology	44
Targeting BET bromodomain proteins in cancer: The example of lymphomas	44
Current state and future perspective of cardiovascular medicines derived from natural products	43
Cyclodextrins: Potential therapeutics against atherosclerosis	43
The regulation of PKA signaling in obesity and in the maintenance of metabolic health	43
An overview on anti-tubulin agents for the treatment of lymphoma patients	43
Signal transduction in primary cilia – analyzing and manipulating GPCR and second messenger signaling	43
Targeting the crosstalk between canonical Wnt/β-catenin and inflammatory signaling cascades: A novel strategy for cancer prevention and therapy	43
Myeloperoxidase: Growing importance in cancer pathogenesis and potential drug target	42
Resolving inflammation by TAM receptor activation	42
Enhancing autophagy in Alzheimer's disease through drug repositioning	42
NF-κB signaling promotes castration-resistant prostate cancer initiation and progression	42
Physiology and pharmacology of amyloid precursor protein	41
Functional metabolomics innovates therapeutic discovery of traditional Chinese medicine derived functional compounds	41
Peroxisome proliferator-activated receptors in the pathogenesis and therapies of liver fibrosis	41
SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin	41
Dietary nutrition for neurological disease therapy: Current status and future directions	41
Induction of programmed necrosis: A novel anti-cancer strategy for natural compounds	41
Cyclooxygenases and the cardiovascular system	40
Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside	40
In cancer, all roads lead to NADPH	40
The role of CD71+ erythroid cells in the regulation of the immune response	39
Modulating tumor-associated macrophages to enhance the efficacy of immune checkpoint inhibitors: A TAM-pting approach	39
Mitochondrial K+ channels and their implications for disease mechanisms	39
Myeloperoxidase: A versatile mediator of endothelial dysfunction and therapeutic target during cardiovascular disease	39
Good or bad: Application of RAAS inhibitors in COVID-19 patients with cardiovascular comorbidities	38
Pulmonary arterial hypertension specific therapy: The old and the new	38
Rational targeting of immunosuppressive neutrophils in cancer	37
TSLP as druggable target – a silver-lining for atopic diseases?	37
Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development	37
PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets	37
Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis	36
Targeting Sirtuin1 to treat aging-related tissue fibrosis: From prevention to therapy	36
Evaluating the benefits of renin-angiotensin system inhibitors as cancer treatments	36
Apical sodium-dependent bile acid transporter, drug target for bile acid related diseases and delivery target for prodrugs: Current and future challenges	36
Glycoprotein VI - novel target in antiplatelet medication	36
Translating biased agonists from molecules to medications: Serotonin 5-HT1A receptor functional selectivity for CNS disorders	35
Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders	35
Long noncoding RNA loss in immune suppression in cancer	35
Inflammation in kidney repair: Mechanism and therapeutic potential	35
A natural products solution to diabetic nephropathy therapy	35
The roles of non-coding RNAs in vascular calcification and opportunities as therapeutic targets	35
Anti-cancer activity of sustained release capsaicin formulations	35
Nanomedicine: Photo-activated nanostructured titanium dioxide, as a promising anticancer agent	35
Functional hydrogels as therapeutic tools for spinal cord injury: New perspectives on immunopharmacological interventions	35
Indoleamine and tryptophan 2,3-dioxygenases as important future therapeutic targets	35
The therapeutic potential of Nrf2 inducers in chronic pain: Evidence from preclinical studies	35
The emerging role of leukemia inhibitory factor in cancer and therapy	35
G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs)	35
The gut microbiome and efficacy of cancer immunotherapy	34
Stem cell therapy in liver regeneration: Focus on mesenchymal stem cells and induced pluripotent stem cells	34
Animal models of fibromyalgia: What is the best choice?	34
Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits	34
The chemistry and toxicology of vaping	34

Branched and linear fatty acid esters of hydroxy fatty acids (FAHFA) relevant to human health	34
Lipid lowering therapy in cardiovascular disease: From myth to molecular reality	33
Emerging mechanisms contributing to mast cell-mediated pathophysiology with therapeutic implications	32
The root cause of drug resistance in HER2-positive breast cancer and the therapeutic approaches to overcoming the resistance	32
CYP2J2 Molecular Recognition: A New Axis for Therapeutic Design	32
Cannabinoids as therapeutics for PTSD	32
Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping	32
Challenges and opportunities in metastatic breast cancer treatments: Nano-drug combinations delivered preferentially to metastatic cells may enhance therapeutic response	31
Signal transducer and activator of transcription 3 signaling in tumor immune evasion	31
Endothelial function and dysfunction: Impact of sodium-glucose cotransporter 2 inhibitors	31
Modulation of the chemokine/chemokine receptor axis as a novel approach for glioma therapy	31
Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies	31
DNA-PK in human malignant disorders: Mechanisms and implications for pharmacological interventions	31
Targeting neurotrophic factors: Novel approaches to musculoskeletal pain	31
Lipopolysaccharide lipid A: A promising molecule for new immunity-based therapies and antibiotics	30
The Multiple Roles of the IAP Super-family in cancer	30
What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience	30
TLR4 biased small molecule modulators	30
Statins and autoimmunity: State-of-the-art	30
The antidepressant actions of ketamine and its enantiomers	29
Resistance looms for KRAS G12C inhibitors and rational tackling strategies	29
The translational values of TRIM family in pan-cancers: From functions and mechanisms to clinics	29
An update on human T-cell leukemia virus type I (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) focusing on clinical and laboratory biomarkers	29
The pathophysiological function of non-gastrointestinal farnesoid X receptor	29
Melanosome transport and regulation in development and disease	29
Public health risks associated with chronic, low-level domoic acid exposure: A review of the evidence	29
Therapeutic potential of sulfur-containing natural products in inflammatory diseases	29
Fenfluramine repurposing from weight loss to epilepsy: What we do and do not know	29
A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor	29
Transitional changes in the structure of C-reactive protein create highly pro-inflammatory molecules: Therapeutic implications for cardiovascular diseases	29
Statins in the treatment of depression: Hype or hope?	29
Transcription factor GLIS3: Critical roles in thyroid hormone biosynthesis, hypothyroidism, pancreatic beta cells and diabetes	29
Exploring the proteasome system: A novel concept of proteasome inhibition and regulation	29
Advances in Trop2-targeted therapy: Novel agents and opportunities beyond breast cancer	29