Pharmacology & Therapeutics

Article	Citations
Tumor microenvironment as a therapeutic target in cancer	784
Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms	315
Idiopathic pulmonary fibrosis: Disease mechanisms and drug development	281
Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?	226
Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients	218
The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species	195
Resolution of inflammation: An organizing principle in biology and medicine	177
The birth of artemisinin	175
Advances in pathogenesis and therapeutic strategies for osteoporosis	172
Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression	165
Programming inflammatory cell death for therapy	132
Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics	128
Bile acid metabolism and signaling, the microbiota, and metabolic disease	127
The strategies and techniques of drug discovery from natural products	125
Therapeutic targets in lung tissue remodelling and fibrosis	125
Natural medicine in neuroprotection for ischemic stroke: Challenges and prospective	122
Inflammation is a major regulator of drug metabolizing enzymes and transporters: Consequences for the personalization of drug treatment	116
Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint	113
Carcinogenesis: Failure of resolution of inflammation?	113
Targeting the NLRP3 inflammasome in cardiovascular diseases	112
Traditional application and modern pharmacological research of Artemisia annua L.	104
Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics	100
Therapeutic potential of resveratrol against emerging respiratory viral infections	100
Evidence-based pharmacological treatment options for ADHD in children and adolescents	97
PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders	96

Drug repurposing for COVID-19: Approaches, challenges and promising candidates	94
The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy	93
Molecular mechanisms of ferroptosis and their involvement in brain diseases	90
Macrophage migration inhibitory factor (MIF): A multifaceted cytokine regulated by genetic and physiological strategies	89
Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders	89
Chinmedomics, a new strategy for evaluating the therapeutic efficacy of herbal medicines	88
Role of inflammatory chemokines in hypertension	85
Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms	84
Stepping forward in antibody-drug conjugate development	83
The natriuretic peptide system in heart failure: Diagnostic and therapeutic implications	82
Triple negative breast cancer (TNBC): Non-genetic tumor heterogeneity and immune microenvironment: Emerging treatment options	80
Polyphenols and neuroprotection: Therapeutic implications for cognitive decline	80
Kynurenine emerges from the shadows – Current knowledge on its fate and function	78
The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention	77
Current developments of targeting the p53 signaling pathway for cancer treatment	76
CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases	76
Updates on community acquired pneumonia management in the ICU	76
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle	76
A decade of cell death studies: Breathing new life into necroptosis	75
Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain	72
The Role of non-coding RNAs in colorectal cancer, with a focus on its autophagy	72
Pharmacological treatment of eating disorders, comorbid mental health problems, malnutrition and physical health consequences	72
Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers	71
Tumor organoid models in precision medicine and investigating cancer-stromal interactions	71
Targeting post-translational histone modifying enzymes in glioblastoma	68
Sirtuins' control of autophagy and mitophagy in cancer	68
Extracellular vesicles in cardiovascular disease: Biological functions and therapeutic implications	67
Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors	67
Immune activities of polysaccharides isolated from Lycium barbarum L. What do we know so far?	66
The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges	66
Double-edged roles of protein tyrosine phosphatase SHP2 in cancer and its inhibitors in clinical trials	65
Macrophage immunometabolism in inflammatory bowel diseases: From pathogenesis to therapy	63
Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases	62
Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases	62
G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects	60
Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression	60
Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications	60
TGFβ-Directed Therapeutics: 2020	60
Particulate matter air pollutants and cardiovascular disease: Strategies for intervention	58
Current and emerging therapies for Duchenne muscular dystrophy and spinal muscular atrophy	57
Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization	56
Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing	56
Novel strategies exploiting interleukin-12 in cancer immunotherapy	56
GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors	55
Treatment of overdose in the synthetic opioid era	55
Prostate Cancer Biomarkers: From diagnosis to prognosis and precision-guided therapeutics	55
A deep dive into UV-based phototherapy: Mechanisms of action and emerging molecular targets in inflammation and cancer	55
Genotoxic therapy and resistance mechanism in gliomas	55
Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19	55
Endothelial shear stress signal transduction and atherogenesis: From mechanisms to therapeutics	55

MERTK in cancer therapy: Targeting the receptor tyrosine kinase in tumor cells and the immune system	54
Vasculogenic mimicry, a complex and devious process favoring tumorigenesis – Interest in making it a therapeutic target	54
Advances in the research on the targets of anti-malaria actions of artemisinin	54
FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention	54
Evolving roles of lysyl oxidase family in tumorigenesis and cancer therapy	53
FGFR4: A promising therapeutic target for breast cancer and other solid tumors	53
Antimicrobial peptides – Unleashing their therapeutic potential using nanotechnology	53
New insights into molecular and cellular mechanisms of zoledronate in human osteosarcoma	53
Clinical therapies and nano drug delivery systems for urinary bladder cancer	53
Review: RNA-based diagnostic markers discovery and therapeutic targets development in cancer	53
Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system	52
Probiotics: Potential novel therapeutics for microbiota-gut-brain axis dysfunction across gender and lifespan	52
Blood-brain barrier leakage in Alzheimer’s disease: From discovery to clinical relevance	51
Toxicology of flavoring- and cannabis-containing e-liquids used in electronic delivery systems	50
Metabolomics, metabolic flux analysis and cancer pharmacology	50
Deliver the promise: RNAs as a new class of molecular entities for therapy and vaccination	50
Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?	49
Enhancing autophagy in Alzheimer's disease through drug repositioning	49
New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology	49
Extracellular vesicles in cancer diagnostics and therapeutics	48
Targeting BET bromodomain proteins in cancer: The example of lymphomas	48
Targeting the crosstalk between canonical Wnt/β-catenin and inflammatory signaling cascades: A novel strategy for cancer prevention and therapy	48
Regulation of organic anion transporters: Role in physiology, pathophysiology, and drug elimination	47
SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin	46
PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets	46
Cyclodextrins: Potential therapeutics against atherosclerosis	46
Resolving inflammation by TAM receptor activation	46
Modulating tumor-associated macrophages to enhance the efficacy of immune checkpoint inhibitors: A TAM-pting approach	45
The regulation of PKA signaling in obesity and in the maintenance of metabolic health	45
Cyclooxygenases and the cardiovascular system	45
The role of CD71+ erythroid cells in the regulation of the immune response	44
Induction of programmed necrosis: A novel anti-cancer strategy for natural compounds	44
Physiology and pharmacology of amyloid precursor protein	44
Dietary nutrition for neurological disease therapy: Current status and future directions	43
Current state and future perspective of cardiovascular medicines derived from natural products	43
Signal transduction in primary cilia – analyzing and manipulating GPCR and second messenger signaling	43
Peroxisome proliferator-activated receptors in the pathogenesis and therapies of liver fibrosis	43
Functional metabolomics innovates therapeutic discovery of traditional Chinese medicine derived functional compounds	43
Inflammation in kidney repair: Mechanism and therapeutic potential	42
A natural products solution to diabetic nephropathy therapy	42
In cancer, all roads lead to NADPH	42
Myeloperoxidase: Growing importance in cancer pathogenesis and potential drug target	42
Myeloperoxidase: A versatile mediator of endothelial dysfunction and therapeutic target during cardiovascular disease	41
G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs)	40
Translating biased agonists from molecules to medications: Serotonin 5-HT1A receptor functional selectivity for CNS disorders	39
The emerging role of leukemia inhibitory factor in cancer and therapy	39
Stem cell therapy in liver regeneration: Focus on mesenchymal stem cells and induced pluripotent stem cells	39
Mitochondrial K+ channels and their implications for disease mechanisms	39
Anti-cancer activity of sustained release capsaicin formulations	39
Pulmonary arterial hypertension specific therapy: The old and the new	39
Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders	39
TSLP as druggable target – a silver-lining for atopic diseases?	39
Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis	38
Nanomedicine: Photo-activated nanostructured titanium dioxide, as a promising anticancer agent	38
The therapeutic potential of Nrf2 inducers in chronic pain: Evidence from preclinical studies	38
Glycoprotein VI - novel target in antiplatelet medication	38
Good or bad: Application of RAAS inhibitors in COVID-19 patients with cardiovascular comorbidities	38
Long noncoding RNA loss in immune suppression in cancer	38
Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development	38
Animal models of fibromyalgia: What is the best choice?	37
Branched and linear fatty acid esters of hydroxy fatty acids (FAHFA) relevant to human health	37
The gut microbiome and efficacy of cancer immunotherapy	37
Functional hydrogels as therapeutic tools for spinal cord injury: New perspectives on immunopharmacological interventions	37
Targeting Sirtuin1 to treat aging-related tissue fibrosis: From prevention to therapy	37
The chemistry and toxicology of vaping	36
Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits	36
Lipid lowering therapy in cardiovascular disease: From myth to molecular reality	35
Statins and autoimmunity: State-of-the-art	35
The roles of non-coding RNAs in vascular calcification and opportunities as therapeutic targets	35
Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping	35
Emerging mechanisms contributing to mast cell-mediated pathophysiology with therapeutic implications	34
The antidepressant actions of ketamine and its enantiomers	34
The root cause of drug resistance in HER2-positive breast cancer and the therapeutic approaches to overcoming the resistance	34
Lipopolysaccharide lipid A: A promising molecule for new immunity-based therapies and antibiotics	33
Therapeutic potential of sulfur-containing natural products in inflammatory diseases	33
An update on human T-cell leukemia virus type I (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) focusing on clinical and laboratory biomarkers	33
The Multiple Roles of the IAP Super-family in cancer	33
Indoleamine and tryptophan 2,3-dioxygenases as important future therapeutic targets	33
Modulation of the chemokine/chemokine receptor axis as a novel approach for glioma therapy	33
Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies	33

CYP2J2 Molecular Recognition: A New Axis for Therapeutic Design	33
Melanosome transport and regulation in development and disease	33
The immune modifying effects of chemotherapy and advances in chemo-immunotherapy	33
Signal transducer and activator of transcription 3 signaling in tumor immune evasion	33
Advances in Trop2-targeted therapy: Novel agents and opportunities beyond breast cancer	33
The role of hypoxia-inducible factors in cardiovascular diseases	32
DNA-PK in human malignant disorders: Mechanisms and implications for pharmacological interventions	32
Recent advances in clinical trials targeting the kynurenine pathway	32
Endothelial function and dysfunction: Impact of sodium-glucose cotransporter 2 inhibitors	32
Challenges and opportunities in metastatic breast cancer treatments: Nano-drug combinations delivered preferentially to metastatic cells may enhance therapeutic response	32
The translational values of TRIM family in pan-cancers: From functions and mechanisms to clinics	31
Clozapine’s multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in tre	31
Integrins in cancer: Emerging mechanisms and therapeutic opportunities	31
What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience	31
Public health risks associated with chronic, low-level domoic acid exposure: A review of the evidence	31
Transitional changes in the structure of C-reactive protein create highly pro-inflammatory molecules: Therapeutic implications for cardiovascular diseases	31
Statins in the treatment of depression: Hype or hope?	31
TLR4 biased small molecule modulators	31
The pathophysiological function of non-gastrointestinal farnesoid X receptor	30
A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor	30
Resistance looms for KRAS G12C inhibitors and rational tackling strategies	30
A natural product solution to aging and aging-associated diseases	30
Mitochondrial metabolism mediated macrophage polarization in chronic lung diseases	30
The IL-18/IL-18R1 signalling axis: Diagnostic and therapeutic potential in hypertension and chronic kidney disease	30