Pharmacology & Therapeutics

(The TQCC of Pharmacology & Therapeutics is 28. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
Tumor microenvironment as a therapeutic target in cancer577
Favipiravir, an anti-influenza drug against life-threatening RNA virus infections344
Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms255
Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?208
Idiopathic pulmonary fibrosis: Disease mechanisms and drug development208
Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients205
Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders204
The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species154
The birth of artemisinin150
Resolution of inflammation: An organizing principle in biology and medicine136
Dipeptidyl peptidase 4 inhibitors and their potential immune modulatory functions133
Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression130
Advances in pathogenesis and therapeutic strategies for osteoporosis128
TRPC channels: Structure, function, regulation and recent advances in small molecular probes123
Pharmacological treatment of migraine: CGRP and 5-HT beyond the triptans107
Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics105
Inflammation is a major regulator of drug metabolizing enzymes and transporters: Consequences for the personalization of drug treatment102
Programming inflammatory cell death for therapy100
Therapeutic targets in lung tissue remodelling and fibrosis97
Carcinogenesis: Failure of resolution of inflammation?96
Natural medicine in neuroprotection for ischemic stroke: Challenges and prospective96
Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential95
The strategies and techniques of drug discovery from natural products95
Therapeutic potential of resveratrol against emerging respiratory viral infections93
Physiologically-based pharmacokinetic models for children: Starting to reach maturation?88
Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint86
Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases86
Drug repurposing for COVID-19: Approaches, challenges and promising candidates84
Traditional application and modern pharmacological research of Artemisia annua L.84
The therapeutic potential of second and third generation CB1R antagonists83
Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis82
Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders81
A hypothesis of monoamine (5-HT) – Glutamate/GABA long neural circuit: Aiming for fast-onset antidepressant discovery77
Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms76
Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics76
The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy76
Chinmedomics, a new strategy for evaluating the therapeutic efficacy of herbal medicines76
Immunotherapy in sepsis - brake or accelerate?76
PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders75
Targeting the NLRP3 inflammasome in cardiovascular diseases75
Role of the ERO1-PDI interaction in oxidative protein folding and disease75
Polyphenols and neuroprotection: Therapeutic implications for cognitive decline71
Role of inflammatory chemokines in hypertension71
Make your best BET: The emerging role of BET inhibitor treatment in malignant tumors69
Biased GPCR signaling: Possible mechanisms and inherent limitations69
Mechano-therapeutics: Targeting Mechanical Signaling in Fibrosis and Tumor Stroma68
Evidence-based pharmacological treatment options for ADHD in children and adolescents68
A decade of cell death studies: Breathing new life into necroptosis68
Bile acid metabolism and signaling, the microbiota, and metabolic disease66
Kynurenine emerges from the shadows – Current knowledge on its fate and function65
Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy65
The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention65
Current developments of targeting the p53 signaling pathway for cancer treatment63
The Role of non-coding RNAs in colorectal cancer, with a focus on its autophagy63
Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis63
Updates on community acquired pneumonia management in the ICU62
The natriuretic peptide system in heart failure: Diagnostic and therapeutic implications61
Macrophage migration inhibitory factor (MIF): A multifaceted cytokine regulated by genetic and physiological strategies61
Role of Rad51 and DNA repair in cancer: A molecular perspective60
The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges60
Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers59
Tumor organoid models in precision medicine and investigating cancer-stromal interactions59
Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors58
Stepping forward in antibody-drug conjugate development57
Targeting post-translational histone modifying enzymes in glioblastoma57
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle57
Triple negative breast cancer (TNBC): Non-genetic tumor heterogeneity and immune microenvironment: Emerging treatment options56
Sirtuins' control of autophagy and mitophagy in cancer56
G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects55
Pharmacology and perspectives in erectile dysfunction in man55
Pharmacological treatment of eating disorders, comorbid mental health problems, malnutrition and physical health consequences55
Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain55
Current and emerging therapies for Duchenne muscular dystrophy and spinal muscular atrophy54
CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases53
Berberine in the treatment of metabolism-related chronic diseases: A drug cloud (dCloud) effect to target multifactorial disorders52
Double-edged roles of protein tyrosine phosphatase SHP2 in cancer and its inhibitors in clinical trials52
A deep dive into UV-based phototherapy: Mechanisms of action and emerging molecular targets in inflammation and cancer52
Effects of local anesthetics on cancer cells51
Acquired resistance to targeted therapies in NSCLC: Updates and evolving insights51
Immune activities of polysaccharides isolated from Lycium barbarum L. What do we know so far?50
Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing50
TGFβ-Directed Therapeutics: 202049
Particulate matter air pollutants and cardiovascular disease: Strategies for intervention49
Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-1949
New insights into molecular and cellular mechanisms of zoledronate in human osteosarcoma48
Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system48
Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases48
GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors47
Extracellular vesicles in cardiovascular disease: Biological functions and therapeutic implications47
FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention47
Genotoxic therapy and resistance mechanism in gliomas46
Advances in the research on the targets of anti-malaria actions of artemisinin45
Evolving roles of lysyl oxidase family in tumorigenesis and cancer therapy45
Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?44
Treatment of overdose in the synthetic opioid era44
Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression44
Endothelial shear stress signal transduction and atherogenesis: From mechanisms to therapeutics43
Molecular mechanisms of ferroptosis and their involvement in brain diseases43
Metabolomics, metabolic flux analysis and cancer pharmacology43
MERTK in cancer therapy: Targeting the receptor tyrosine kinase in tumor cells and the immune system43
Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization43
Vasculogenic mimicry, a complex and devious process favoring tumorigenesis – Interest in making it a therapeutic target42
Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications42
FGFR4: A promising therapeutic target for breast cancer and other solid tumors42
Prostate Cancer Biomarkers: From diagnosis to prognosis and precision-guided therapeutics42
Toxicology of flavoring- and cannabis-containing e-liquids used in electronic delivery systems42
Molecular imaging of inflammation - Current and emerging technologies for diagnosis and treatment42
Extracellular vesicles in cancer diagnostics and therapeutics42
Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases42
An overview on anti-tubulin agents for the treatment of lymphoma patients42
Clinical therapies and nano drug delivery systems for urinary bladder cancer42
Regulation of organic anion transporters: Role in physiology, pathophysiology, and drug elimination42
Antimicrobial peptides – Unleashing their therapeutic potential using nanotechnology41
New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology41
Antifungal effects of statins41
Macrophage immunometabolism in inflammatory bowel diseases: From pathogenesis to therapy41
Endozepines and their receptors: Structure, functions and pathophysiological significance41
Current state and future perspective of cardiovascular medicines derived from natural products41
Oxidation-reduction mechanisms in psychiatric disorders: A novel target for pharmacological intervention40
Blood-brain barrier leakage in Alzheimer’s disease: From discovery to clinical relevance40
Cyclodextrins: Potential therapeutics against atherosclerosis40
Targeting BET bromodomain proteins in cancer: The example of lymphomas40
Deliver the promise: RNAs as a new class of molecular entities for therapy and vaccination39
Targeting the crosstalk between canonical Wnt/β-catenin and inflammatory signaling cascades: A novel strategy for cancer prevention and therapy39
Myeloperoxidase: A versatile mediator of endothelial dysfunction and therapeutic target during cardiovascular disease38
Good or bad: Application of RAAS inhibitors in COVID-19 patients with cardiovascular comorbidities38
Review: RNA-based diagnostic markers discovery and therapeutic targets development in cancer38
NF-κB signaling promotes castration-resistant prostate cancer initiation and progression38
Recent advances in genome editing of stem cells for drug discovery and therapeutic application37
Induction of programmed necrosis: A novel anti-cancer strategy for natural compounds37
Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside37
Probiotics: Potential novel therapeutics for microbiota-gut-brain axis dysfunction across gender and lifespan37
Evaluating the benefits of renin-angiotensin system inhibitors as cancer treatments36
The role of CD71+ erythroid cells in the regulation of the immune response36
Pulmonary arterial hypertension specific therapy: The old and the new36
Signal transduction in primary cilia – analyzing and manipulating GPCR and second messenger signaling36
Novel strategies exploiting interleukin-12 in cancer immunotherapy36
Peroxisome proliferator-activated receptors in the pathogenesis and therapies of liver fibrosis36
Medulloblastoma: Molecular understanding, treatment evolution, and new developments35
The regulation of PKA signaling in obesity and in the maintenance of metabolic health35
Targeting Sirtuin1 to treat aging-related tissue fibrosis: From prevention to therapy35
In cancer, all roads lead to NADPH35
SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin35
Enhancing autophagy in Alzheimer's disease through drug repositioning34
Glycoprotein VI - novel target in antiplatelet medication34
Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development34
TSLP as druggable target – a silver-lining for atopic diseases?34
Cyclooxygenases and the cardiovascular system34
Rational targeting of immunosuppressive neutrophils in cancer34
Keep an eye on adenosine: Its role in retinal inflammation34
Pharmacological targets of metabolism in disease: Opportunities from macrophages33
Apical sodium-dependent bile acid transporter, drug target for bile acid related diseases and delivery target for prodrugs: Current and future challenges33
The therapeutic potential of Nrf2 inducers in chronic pain: Evidence from preclinical studies33
Functional metabolomics innovates therapeutic discovery of traditional Chinese medicine derived functional compounds33
Functional hydrogels as therapeutic tools for spinal cord injury: New perspectives on immunopharmacological interventions33
The roles of non-coding RNAs in vascular calcification and opportunities as therapeutic targets33
TSH/IGF1 receptor crosstalk: Mechanism and clinical implications33
Dietary nutrition for neurological disease therapy: Current status and future directions32
Myeloperoxidase: Growing importance in cancer pathogenesis and potential drug target32
Resolving inflammation by TAM receptor activation32
Physiology and pharmacology of amyloid precursor protein32
Long noncoding RNA loss in immune suppression in cancer32
Translating biased agonists from molecules to medications: Serotonin 5-HT1A receptor functional selectivity for CNS disorders32
Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis32
The emerging role of leukemia inhibitory factor in cancer and therapy32
Stem cell therapy in liver regeneration: Focus on mesenchymal stem cells and induced pluripotent stem cells31
Lipid lowering therapy in cardiovascular disease: From myth to molecular reality31
Inflammation in kidney repair: Mechanism and therapeutic potential31
Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies31
The chemistry and toxicology of vaping31
Do antidepressants promote neurogenesis in adult hippocampus? A systematic review and meta-analysis on naive rodents30
Modulating tumor-associated macrophages to enhance the efficacy of immune checkpoint inhibitors: A TAM-pting approach30
Indoleamine and tryptophan 2,3-dioxygenases as important future therapeutic targets30
Nanomedicine: Photo-activated nanostructured titanium dioxide, as a promising anticancer agent30
CYP2J2 Molecular Recognition: A New Axis for Therapeutic Design30
Cannabinoids as therapeutics for PTSD30
Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders30
Emerging mechanisms contributing to mast cell-mediated pathophysiology with therapeutic implications30
What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience29
A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor29
Statins and autoimmunity: State-of-the-art29
Mitochondrial K+ channels and their implications for disease mechanisms29
G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs)29
Resistance looms for KRAS G12C inhibitors and rational tackling strategies28
Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits28
TLR4 biased small molecule modulators28
Animal models of fibromyalgia: What is the best choice?28
Branched and linear fatty acid esters of hydroxy fatty acids (FAHFA) relevant to human health28
Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping28
The gut microbiome and efficacy of cancer immunotherapy28
The Multiple Roles of the IAP Super-family in cancer28