Pharmacology & Therapeutics

(The TQCC of Pharmacology & Therapeutics is 27. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-09-01 to 2023-09-01.)
5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future331
Tumor microenvironment as a therapeutic target in cancer317
Favipiravir, an anti-influenza drug against life-threatening RNA virus infections297
Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony228
Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients188
Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?184
Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms181
A review of bispecific antibodies and antibody constructs in oncology and clinical challenges171
Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders169
Lactate/GPR81 signaling and proton motive force in cancer: Role in angiogenesis, immune escape, nutrition, and Warburg phenomenon142
Idiopathic pulmonary fibrosis: Disease mechanisms and drug development122
Dipeptidyl peptidase 4 inhibitors and their potential immune modulatory functions117
ATM in DNA repair in cancer116
Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders115
The origin of NMDA receptor hypofunction in schizophrenia109
The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species105
The birth of artemisinin103
Resolution of inflammation: An organizing principle in biology and medicine101
Cancer the‘RBP’eutics–RNA-binding proteins as therapeutic targets for cancer98
TRPC channels: Structure, function, regulation and recent advances in small molecular probes96
Pharmacological treatment of migraine: CGRP and 5-HT beyond the triptans92
Adeno-associated viral vector-mediated immune responses: Understanding barriers to gene delivery91
Schlafen 11 (SLFN11), a restriction factor for replicative stress induced by DNA-targeting anti-cancer therapies90
Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression89
Drug resistance to targeted therapeutic strategies in non-small cell lung cancer88
Targeting ATR as Cancer Therapy: A new era for synthetic lethality and synergistic combinations?85
Circulating tumor DNA as an early cancer detection tool84
Therapeutic potential of resveratrol against emerging respiratory viral infections84
An update for epilepsy research and antiepileptic drug development: Toward precise circuit therapy82
The past, present and future perspectives of matrix metalloproteinase inhibitors82
Carcinogenesis: Failure of resolution of inflammation?81
Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential80
Inflammation is a major regulator of drug metabolizing enzymes and transporters: Consequences for the personalization of drug treatment79
Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target78
Physiologically-based pharmacokinetic models for children: Starting to reach maturation?74
Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases74
Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics74
The therapeutic potential of second and third generation CB1R antagonists73
Therapeutic targets in lung tissue remodelling and fibrosis72
Traditional application and modern pharmacological research of Artemisia annua L.71
Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders71
The unfolded protein response and hepatic lipid metabolism in non alcoholic fatty liver disease71
Drug repurposing for COVID-19: Approaches, challenges and promising candidates70
Dopamine outside the brain: The eye, cardiovascular system and endocrine pancreas68
Clinical investigation of CAR T cells for solid tumors: Lessons learned and future directions68
Advances in pathogenesis and therapeutic strategies for osteoporosis67
Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis66
Ursodeoxycholic acid and cancer: From chemoprevention to chemotherapy65
Immunotherapy in sepsis - brake or accelerate?64
Roles of chitinase 3-like 1 in the development of cancer, neurodegenerative diseases, and inflammatory diseases63
Natural medicine in neuroprotection for ischemic stroke: Challenges and prospective63
Mechano-therapeutics: Targeting Mechanical Signaling in Fibrosis and Tumor Stroma61
The strategies and techniques of drug discovery from natural products60
Programming inflammatory cell death for therapy59
Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining59
Make your best BET: The emerging role of BET inhibitor treatment in malignant tumors59
Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint58
A hypothesis of monoamine (5-HT) – Glutamate/GABA long neural circuit: Aiming for fast-onset antidepressant discovery58
Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis58
The Role of non-coding RNAs in colorectal cancer, with a focus on its autophagy57
Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms57
Drugging K-RasG12C through covalent inhibitors: Mission possible?57
Biased GPCR signaling: Possible mechanisms and inherent limitations57
Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases56
A decade of cell death studies: Breathing new life into necroptosis55
Role of the ERO1-PDI interaction in oxidative protein folding and disease55
PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders55
Chinmedomics, a new strategy for evaluating the therapeutic efficacy of herbal medicines55
Polyphenols and neuroprotection: Therapeutic implications for cognitive decline54
Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics54
Role of Rad51 and DNA repair in cancer: A molecular perspective54
Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration53
TP53 in bone and soft tissue sarcomas53
Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy53
Adolescent neurodevelopment and substance use: Receptor expression and behavioral consequences52
Targeting opioid dysregulation in depression for the development of novel therapeutics52
A marijuana-drug interaction primer: Precipitants, pharmacology, and pharmacokinetics52
Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers51
The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges51
G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects50
The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy48
Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors48
Current and emerging therapies for Duchenne muscular dystrophy and spinal muscular atrophy47
Current developments of targeting the p53 signaling pathway for cancer treatment47
Kynurenine emerges from the shadows – Current knowledge on its fate and function47
Targeting post-translational histone modifying enzymes in glioblastoma46
Berberine in the treatment of metabolism-related chronic diseases: A drug cloud (dCloud) effect to target multifactorial disorders46
Lorcaserin: A review of its preclinical and clinical pharmacology and therapeutic potential45
Sirtuins' control of autophagy and mitophagy in cancer45
Tumor organoid models in precision medicine and investigating cancer-stromal interactions44
Pharmacology and perspectives in erectile dysfunction in man44
Pharmacological treatment of eating disorders, comorbid mental health problems, malnutrition and physical health consequences44
Autophagy as a novel therapeutic target in vascular calcification44
Role of inflammatory chemokines in hypertension44
Cellular determinants and therapeutic implications of inflammation in pancreatic cancer43
Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?43
Acquired resistance to targeted therapies in NSCLC: Updates and evolving insights43
Updates on community acquired pneumonia management in the ICU43
Effects of local anesthetics on cancer cells43
Aldehyde oxidase and its role as a drug metabolizing enzyme42
A deep dive into UV-based phototherapy: Mechanisms of action and emerging molecular targets in inflammation and cancer42
Molecular mechanisms of cereblon-based drugs42
Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-1941
The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention41
Extracellular vesicles in cancer diagnostics and therapeutics39
TGFβ-Directed Therapeutics: 202039
Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system39
Endozepines and their receptors: Structure, functions and pathophysiological significance38
Targeting BET bromodomain proteins in cancer: The example of lymphomas38
FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention38
Evolving roles of lysyl oxidase family in tumorigenesis and cancer therapy38
Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain38
New insights into molecular and cellular mechanisms of zoledronate in human osteosarcoma38
The natriuretic peptide system in heart failure: Diagnostic and therapeutic implications38
Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases38
Particulate matter air pollutants and cardiovascular disease: Strategies for intervention37
Double-edged roles of protein tyrosine phosphatase SHP2 in cancer and its inhibitors in clinical trials37
Molecular imaging of inflammation - Current and emerging technologies for diagnosis and treatment36
Evidence-based pharmacological treatment options for ADHD in children and adolescents36
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle36
Cognitive dysfunction in major depression: From assessment to novel therapies36
Targeting the NLRP3 inflammasome in cardiovascular diseases36
Live cell imaging of signaling and metabolic activities35
Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing35
An overview on anti-tubulin agents for the treatment of lymphoma patients35
Chronopharmacological strategies focused on chrono-drug discovery35
Advances in the research on the targets of anti-malaria actions of artemisinin35
Metabolomics, metabolic flux analysis and cancer pharmacology35
Long non-coding RNAs as new regulators of cardiac electrophysiology and arrhythmias: Molecular mechanisms, therapeutic implications and challenges34
Review: Serum biomarkers in idiopathic pulmonary fibrosis and systemic sclerosis associated interstitial lung disease – frontiers and horizons34
Good or bad: Application of RAAS inhibitors in COVID-19 patients with cardiovascular comorbidities34
Drug resistance in non-small cell lung Cancer (NSCLC): Impact of genetic and non-genetic alterations on therapeutic regimen and responsiveness34
Oxidation-reduction mechanisms in psychiatric disorders: A novel target for pharmacological intervention34
Recent advances in genome editing of stem cells for drug discovery and therapeutic application34
MERTK in cancer therapy: Targeting the receptor tyrosine kinase in tumor cells and the immune system33
Cyclodextrins: Potential therapeutics against atherosclerosis33
Current state and future perspective of cardiovascular medicines derived from natural products33
Cancer immunotherapy with immunoadjuvants, nanoparticles, and checkpoint inhibitors: Recent progress and challenges in treatment and tracking response to immunotherapy33
Genotoxic therapy and resistance mechanism in gliomas33
Macrophage migration inhibitory factor (MIF): A multifaceted cytokine regulated by genetic and physiological strategies33
Keep an eye on adenosine: Its role in retinal inflammation33
Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications32
CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases32
GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors32
Medulloblastoma: Molecular understanding, treatment evolution, and new developments32
Evaluating the benefits of renin-angiotensin system inhibitors as cancer treatments32
Vascular Disrupting Agents in cancer treatment: Cardiovascular toxicity and implications for co-administration with other cancer chemotherapeutics32
Immune activities of polysaccharides isolated from Lycium barbarum L. What do we know so far?32
FGFR4: A promising therapeutic target for breast cancer and other solid tumors32
Stepping forward in antibody-drug conjugate development32
A review on the pathophysiology of asthma remission31
Regulation of organic anion transporters: Role in physiology, pathophysiology, and drug elimination31
Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression31
Lysophosphatidic acid and its receptors: pharmacology and therapeutic potential in atherosclerosis and vascular disease31
Inhibition of serotonin synthesis: A novel therapeutic paradigm31
Prostate Cancer Biomarkers: From diagnosis to prognosis and precision-guided therapeutics31
Understanding the mechanism of radiation induced fibrosis and therapy options31
In cancer, all roads lead to NADPH30
Targeting the crosstalk between canonical Wnt/β-catenin and inflammatory signaling cascades: A novel strategy for cancer prevention and therapy30
Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside30
Myeloperoxidase: A versatile mediator of endothelial dysfunction and therapeutic target during cardiovascular disease30
Antifungal effects of statins30
Toxicology of flavoring- and cannabis-containing e-liquids used in electronic delivery systems30
Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization30
The role of CD71+ erythroid cells in the regulation of the immune response29
Glycoprotein VI - novel target in antiplatelet medication29
Pulmonary arterial hypertension specific therapy: The old and the new29
Lipid lowering therapy in cardiovascular disease: From myth to molecular reality29
Long noncoding RNA loss in immune suppression in cancer29
Clinical therapies and nano drug delivery systems for urinary bladder cancer29
CYP2J2 Molecular Recognition: A New Axis for Therapeutic Design29
The roles of non-coding RNAs in vascular calcification and opportunities as therapeutic targets29
Antimicrobial peptides – Unleashing their therapeutic potential using nanotechnology29
Targeting epigenetic machinery: Emerging novel allosteric inhibitors29
Vasculogenic mimicry, a complex and devious process favoring tumorigenesis – Interest in making it a therapeutic target29
NF-κB signaling promotes castration-resistant prostate cancer initiation and progression28
Deliver the promise: RNAs as a new class of molecular entities for therapy and vaccination28
Recent advances in bone-targeted therapy28
A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor28
Pharmacological targets of metabolism in disease: Opportunities from macrophages28
SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin28
TSLP as druggable target – a silver-lining for atopic diseases?28
Dietary nutrition for neurological disease therapy: Current status and future directions27
Rational targeting of immunosuppressive neutrophils in cancer27
Blood-brain barrier leakage in Alzheimer’s disease: From discovery to clinical relevance27
Triple negative breast cancer (TNBC): Non-genetic tumor heterogeneity and immune microenvironment: Emerging treatment options27
Peroxisome proliferator-activated receptors in the pathogenesis and therapies of liver fibrosis27
Cannabinoids as therapeutics for PTSD27
Apical sodium-dependent bile acid transporter, drug target for bile acid related diseases and delivery target for prodrugs: Current and future challenges27