Pharmacology & Therapeutics

Article	Citations
Tumor microenvironment as a therapeutic target in cancer	577
Favipiravir, an anti-influenza drug against life-threatening RNA virus infections	344
Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms	255
Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?	208
Idiopathic pulmonary fibrosis: Disease mechanisms and drug development	208
Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients	205
Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders	204
The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species	154
The birth of artemisinin	150
Resolution of inflammation: An organizing principle in biology and medicine	136
Dipeptidyl peptidase 4 inhibitors and their potential immune modulatory functions	133
Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression	130
Advances in pathogenesis and therapeutic strategies for osteoporosis	128
TRPC channels: Structure, function, regulation and recent advances in small molecular probes	123
Pharmacological treatment of migraine: CGRP and 5-HT beyond the triptans	107
Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics	105
Inflammation is a major regulator of drug metabolizing enzymes and transporters: Consequences for the personalization of drug treatment	102
Programming inflammatory cell death for therapy	100
Therapeutic targets in lung tissue remodelling and fibrosis	97
Natural medicine in neuroprotection for ischemic stroke: Challenges and prospective	96
Carcinogenesis: Failure of resolution of inflammation?	96
Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential	95
The strategies and techniques of drug discovery from natural products	95
Therapeutic potential of resveratrol against emerging respiratory viral infections	93
Physiologically-based pharmacokinetic models for children: Starting to reach maturation?	88

Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint	86
Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases	86
Traditional application and modern pharmacological research of Artemisia annua L.	84
Drug repurposing for COVID-19: Approaches, challenges and promising candidates	84
The therapeutic potential of second and third generation CB1R antagonists	83
Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis	82
Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders	81
A hypothesis of monoamine (5-HT) – Glutamate/GABA long neural circuit: Aiming for fast-onset antidepressant discovery	77
The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy	76
Chinmedomics, a new strategy for evaluating the therapeutic efficacy of herbal medicines	76
Immunotherapy in sepsis - brake or accelerate?	76
Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms	76
Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics	76
Targeting the NLRP3 inflammasome in cardiovascular diseases	75
Role of the ERO1-PDI interaction in oxidative protein folding and disease	75
PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders	75
Polyphenols and neuroprotection: Therapeutic implications for cognitive decline	71
Role of inflammatory chemokines in hypertension	71
Biased GPCR signaling: Possible mechanisms and inherent limitations	69
Make your best BET: The emerging role of BET inhibitor treatment in malignant tumors	69
Evidence-based pharmacological treatment options for ADHD in children and adolescents	68
A decade of cell death studies: Breathing new life into necroptosis	68
Mechano-therapeutics: Targeting Mechanical Signaling in Fibrosis and Tumor Stroma	68
Bile acid metabolism and signaling, the microbiota, and metabolic disease	66
Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy	65
The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention	65
Kynurenine emerges from the shadows – Current knowledge on its fate and function	65
The Role of non-coding RNAs in colorectal cancer, with a focus on its autophagy	63
Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis	63
Current developments of targeting the p53 signaling pathway for cancer treatment	63
Updates on community acquired pneumonia management in the ICU	62
Macrophage migration inhibitory factor (MIF): A multifaceted cytokine regulated by genetic and physiological strategies	61
The natriuretic peptide system in heart failure: Diagnostic and therapeutic implications	61
The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges	60
Role of Rad51 and DNA repair in cancer: A molecular perspective	60
Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers	59
Tumor organoid models in precision medicine and investigating cancer-stromal interactions	59
Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors	58
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle	57
Stepping forward in antibody-drug conjugate development	57
Targeting post-translational histone modifying enzymes in glioblastoma	57
Sirtuins' control of autophagy and mitophagy in cancer	56
Triple negative breast cancer (TNBC): Non-genetic tumor heterogeneity and immune microenvironment: Emerging treatment options	56
Pharmacology and perspectives in erectile dysfunction in man	55
Pharmacological treatment of eating disorders, comorbid mental health problems, malnutrition and physical health consequences	55
Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain	55
G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects	55
Current and emerging therapies for Duchenne muscular dystrophy and spinal muscular atrophy	54
CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases	53
Double-edged roles of protein tyrosine phosphatase SHP2 in cancer and its inhibitors in clinical trials	52

A deep dive into UV-based phototherapy: Mechanisms of action and emerging molecular targets in inflammation and cancer	52
Berberine in the treatment of metabolism-related chronic diseases: A drug cloud (dCloud) effect to target multifactorial disorders	52
Acquired resistance to targeted therapies in NSCLC: Updates and evolving insights	51
Effects of local anesthetics on cancer cells	51
Immune activities of polysaccharides isolated from Lycium barbarum L. What do we know so far?	50
Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing	50
Particulate matter air pollutants and cardiovascular disease: Strategies for intervention	49
Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19	49
TGFβ-Directed Therapeutics: 2020	49
Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system	48
Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases	48
New insights into molecular and cellular mechanisms of zoledronate in human osteosarcoma	48
Extracellular vesicles in cardiovascular disease: Biological functions and therapeutic implications	47
FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention	47
GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors	47
Genotoxic therapy and resistance mechanism in gliomas	46
Advances in the research on the targets of anti-malaria actions of artemisinin	45
Evolving roles of lysyl oxidase family in tumorigenesis and cancer therapy	45
Treatment of overdose in the synthetic opioid era	44
Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression	44
Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?	44
Metabolomics, metabolic flux analysis and cancer pharmacology	43
MERTK in cancer therapy: Targeting the receptor tyrosine kinase in tumor cells and the immune system	43
Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization	43
Endothelial shear stress signal transduction and atherogenesis: From mechanisms to therapeutics	43
Molecular mechanisms of ferroptosis and their involvement in brain diseases	43
Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications	42
FGFR4: A promising therapeutic target for breast cancer and other solid tumors	42
Prostate Cancer Biomarkers: From diagnosis to prognosis and precision-guided therapeutics	42
Toxicology of flavoring- and cannabis-containing e-liquids used in electronic delivery systems	42
Molecular imaging of inflammation - Current and emerging technologies for diagnosis and treatment	42
Extracellular vesicles in cancer diagnostics and therapeutics	42
Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases	42
An overview on anti-tubulin agents for the treatment of lymphoma patients	42
Clinical therapies and nano drug delivery systems for urinary bladder cancer	42
Regulation of organic anion transporters: Role in physiology, pathophysiology, and drug elimination	42
Vasculogenic mimicry, a complex and devious process favoring tumorigenesis – Interest in making it a therapeutic target	42
Antifungal effects of statins	41
Macrophage immunometabolism in inflammatory bowel diseases: From pathogenesis to therapy	41
Endozepines and their receptors: Structure, functions and pathophysiological significance	41
Current state and future perspective of cardiovascular medicines derived from natural products	41
Antimicrobial peptides – Unleashing their therapeutic potential using nanotechnology	41
New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology	41
Blood-brain barrier leakage in Alzheimer’s disease: From discovery to clinical relevance	40
Cyclodextrins: Potential therapeutics against atherosclerosis	40
Targeting BET bromodomain proteins in cancer: The example of lymphomas	40
Oxidation-reduction mechanisms in psychiatric disorders: A novel target for pharmacological intervention	40
Targeting the crosstalk between canonical Wnt/β-catenin and inflammatory signaling cascades: A novel strategy for cancer prevention and therapy	39
Deliver the promise: RNAs as a new class of molecular entities for therapy and vaccination	39
Good or bad: Application of RAAS inhibitors in COVID-19 patients with cardiovascular comorbidities	38
Review: RNA-based diagnostic markers discovery and therapeutic targets development in cancer	38
NF-κB signaling promotes castration-resistant prostate cancer initiation and progression	38
Myeloperoxidase: A versatile mediator of endothelial dysfunction and therapeutic target during cardiovascular disease	38
Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside	37
Probiotics: Potential novel therapeutics for microbiota-gut-brain axis dysfunction across gender and lifespan	37
Recent advances in genome editing of stem cells for drug discovery and therapeutic application	37
Induction of programmed necrosis: A novel anti-cancer strategy for natural compounds	37
The role of CD71+ erythroid cells in the regulation of the immune response	36
Pulmonary arterial hypertension specific therapy: The old and the new	36
Signal transduction in primary cilia – analyzing and manipulating GPCR and second messenger signaling	36
Novel strategies exploiting interleukin-12 in cancer immunotherapy	36
Peroxisome proliferator-activated receptors in the pathogenesis and therapies of liver fibrosis	36
Evaluating the benefits of renin-angiotensin system inhibitors as cancer treatments	36
Medulloblastoma: Molecular understanding, treatment evolution, and new developments	35
The regulation of PKA signaling in obesity and in the maintenance of metabolic health	35
Targeting Sirtuin1 to treat aging-related tissue fibrosis: From prevention to therapy	35
In cancer, all roads lead to NADPH	35
SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin	35
Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development	34
TSLP as druggable target – a silver-lining for atopic diseases?	34
Cyclooxygenases and the cardiovascular system	34
Rational targeting of immunosuppressive neutrophils in cancer	34
Keep an eye on adenosine: Its role in retinal inflammation	34
Enhancing autophagy in Alzheimer's disease through drug repositioning	34
Glycoprotein VI - novel target in antiplatelet medication	34
The therapeutic potential of Nrf2 inducers in chronic pain: Evidence from preclinical studies	33
Functional metabolomics innovates therapeutic discovery of traditional Chinese medicine derived functional compounds	33
Functional hydrogels as therapeutic tools for spinal cord injury: New perspectives on immunopharmacological interventions	33
The roles of non-coding RNAs in vascular calcification and opportunities as therapeutic targets	33
TSH/IGF1 receptor crosstalk: Mechanism and clinical implications	33

Pharmacological targets of metabolism in disease: Opportunities from macrophages	33
Apical sodium-dependent bile acid transporter, drug target for bile acid related diseases and delivery target for prodrugs: Current and future challenges	33
Physiology and pharmacology of amyloid precursor protein	32
Long noncoding RNA loss in immune suppression in cancer	32
Translating biased agonists from molecules to medications: Serotonin 5-HT1A receptor functional selectivity for CNS disorders	32
Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis	32
The emerging role of leukemia inhibitory factor in cancer and therapy	32
Dietary nutrition for neurological disease therapy: Current status and future directions	32
Myeloperoxidase: Growing importance in cancer pathogenesis and potential drug target	32
Resolving inflammation by TAM receptor activation	32
Lipid lowering therapy in cardiovascular disease: From myth to molecular reality	31
Inflammation in kidney repair: Mechanism and therapeutic potential	31
Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies	31
The chemistry and toxicology of vaping	31
Stem cell therapy in liver regeneration: Focus on mesenchymal stem cells and induced pluripotent stem cells	31
Do antidepressants promote neurogenesis in adult hippocampus? A systematic review and meta-analysis on naive rodents	30
Modulating tumor-associated macrophages to enhance the efficacy of immune checkpoint inhibitors: A TAM-pting approach	30
Indoleamine and tryptophan 2,3-dioxygenases as important future therapeutic targets	30
Nanomedicine: Photo-activated nanostructured titanium dioxide, as a promising anticancer agent	30
CYP2J2 Molecular Recognition: A New Axis for Therapeutic Design	30
Cannabinoids as therapeutics for PTSD	30
Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders	30
Emerging mechanisms contributing to mast cell-mediated pathophysiology with therapeutic implications	30
Statins and autoimmunity: State-of-the-art	29
Mitochondrial K+ channels and their implications for disease mechanisms	29
G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs)	29
What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience	29
A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor	29
Animal models of fibromyalgia: What is the best choice?	28
Branched and linear fatty acid esters of hydroxy fatty acids (FAHFA) relevant to human health	28
Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping	28
The gut microbiome and efficacy of cancer immunotherapy	28
The Multiple Roles of the IAP Super-family in cancer	28
Resistance looms for KRAS G12C inhibitors and rational tackling strategies	28
Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits	28
TLR4 biased small molecule modulators	28
Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor	27
Targeting prostaglandin receptor EP2 for adjunctive treatment of status epilepticus	27
The translational values of TRIM family in pan-cancers: From functions and mechanisms to clinics	27
NRF2 in human neoplasm: Cancer biology and potential therapeutic target	27
Fenfluramine repurposing from weight loss to epilepsy: What we do and do not know	27
Transcription factor GLIS3: Critical roles in thyroid hormone biosynthesis, hypothyroidism, pancreatic beta cells and diabetes	27
Melanosome transport and regulation in development and disease	27
Therapeutic potential of sulfur-containing natural products in inflammatory diseases	27
DNA-PK in human malignant disorders: Mechanisms and implications for pharmacological interventions	27
Public health risks associated with chronic, low-level domoic acid exposure: A review of the evidence	27
The root cause of drug resistance in HER2-positive breast cancer and the therapeutic approaches to overcoming the resistance	27
Cyclic nucleotide phosphodiesterases: New targets in the metabolic syndrome?	27
Modulation of the chemokine/chemokine receptor axis as a novel approach for glioma therapy	27
Signal transducer and activator of transcription 3 signaling in tumor immune evasion	27
Transitional changes in the structure of C-reactive protein create highly pro-inflammatory molecules: Therapeutic implications for cardiovascular diseases	26
Anti-cancer activity of sustained release capsaicin formulations	26
Endothelial function and dysfunction: Impact of sodium-glucose cotransporter 2 inhibitors	26
Challenges and opportunities in metastatic breast cancer treatments: Nano-drug combinations delivered preferentially to metastatic cells may enhance therapeutic response	26
The pathophysiological function of non-gastrointestinal farnesoid X receptor	26
A natural product solution to aging and aging-associated diseases	26
Exploring the proteasome system: A novel concept of proteasome inhibition and regulation	26
Targeting neurotrophic factors: Novel approaches to musculoskeletal pain	26
Ion channels as effectors of cyclic nucleotide pathways: Functional relevance for arterial tone regulation	25
A BAG's life: Every connection matters in cancer	25
The role of hypoxia-inducible factors in cardiovascular diseases	25
The immune modifying effects of chemotherapy and advances in chemo-immunotherapy	25
Nitrite and myocardial ischaemia reperfusion injury. Where are we now?	25
Novel insights into RIPK1 as a promising target for future Alzheimer’s disease treatment	25
Statins in the treatment of depression: Hype or hope?	25
Targeting defective pulmonary innate immunity – A new therapeutic option?	25
Efficacy and mechanism of actions of natural antimicrobial drugs	24
Advances in the pathophysiology of atopic dermatitis revealed by novel therapeutics and clinical trials	24
Target identification and validation of natural products with label-free methodology: A critical review from 2005 to 2020	24
Approaches to improve intestinal and transmucosal absorption of peptide and protein drugs	24
An update on human T-cell leukemia virus type I (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) focusing on clinical and laboratory biomarkers	24
The role of the brain renin-angiotensin system (RAS) in mild traumatic brain injury (TBI)	23
Cannabinoids in the descending pain modulatory circuit: Role in inflammation	23
A natural products solution to diabetic nephropathy therapy	23
Recent advances in clinical trials targeting the kynurenine pathway	23
Addiction and the kynurenine pathway: A new dancing couple?	22
Advances in Trop2-targeted therapy: Novel agents and opportunities beyond breast cancer	22
Transport function, regulation, and biology of human monocarboxylate transporter 1 (hMCT1) and 4 (hMCT4)	22
Molecular mechanisms and therapeutic implications of tetrandrine and cepharanthine in T cell acute lymphoblastic leukemia and autoimmune diseases	22
Vitamin A in health care: Suppression of growth and induction of differentiation in cancer cells by vitamin A and its derivatives and their mechanisms of action	22
Targeting the human microbiome and its metabolite TMAO in cardiovascular prevention and therapy	22
Recent advances in studies of SLCO2A1 as a key regulator of the delivery of prostaglandins to their sites of action	22
The evolving obesity challenge: targeting the vagus nerve and the inflammatory reflex in the response	21
The contribution of altered neuronal autophagy to neurodegeneration	21
Nicotine’ actions on energy balance: Friend or foe?	21
RANKL as a key figure in bridging between the bone and immune system: Its physiological functions and potential as a pharmacological target	21
Novel molecular targets in gastric adenocarcinoma	21
Pharmacokinetics, metabolism and serum concentrations of progestins used in contraception	21
Diverse therapeutic developments for post-traumatic stress disorder (PTSD) indicate common mechanisms of memory modulation	21
Time is of the essence: Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine	21
Oncolytic ImmunoViroTherapy: A long history of crosstalk between viruses and immune system for cancer treatment	21
Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters	21
The antidepressant actions of ketamine and its enantiomers	21
Molecular mechanisms and cardiovascular implications of cancer therapy-induced senescence	21
Extracellular vesicles in hepatology: Physiological role, involvement in pathogenesis, and therapeutic opportunities	21