Pharmacology & Therapeutics

Article	Citations
WITHDRAWN: 17th International conference on bioactive lipids in cancer, inflammation and related diseases virtual special issue	1167
Unfolded protein responses: Dynamic machinery in wound healing	384
Exploiting the obesity-associated immune microenvironment for cancer therapeutics	382
Measuring brain docosahexaenoic acid turnover as a marker of metabolic consumption	278
HIV-associated neurotoxicity and cognitive decline: Therapeutic implications	265
Editorial Board	234
Collateral lethality: A unique type of synthetic lethality in cancers	206
Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: A systematic review and meta-analysis	200
The role of macrophages in asthma-related fibrosis and remodelling	179
Non-canonical G protein signaling	177
New therapeutic horizons for plasma phospholipid transfer protein (PLTP): Targeting endotoxemia, infection and sepsis	171
Potential neonatal toxicity of new psychoactive substances	162
Adenosine receptor signalling as a driver of pulmonary fibrosis	151
Matrikines in the skin: Origin, effects, and therapeutic potential	143
Unlocking the power of affibody conjugated radioactive metallopharmaceuticals for targeted cancer diagnosis and therapy	143
Vasculogenic mimicry, a complex and devious process favoring tumorigenesis – Interest in making it a therapeutic target	129
Endothelial dysfunction as a complication of anti-cancer therapy	129
Inflammation, lipids, and pain in vulvar disease	118
In cancer, all roads lead to NADPH	117
Cell-based therapies for vascular regeneration: Past, present and future	115
Regulatory lipid vicinal diols counteract the biological activity of epoxy fatty acids and can act as biomarkers and mechanisms for disease progression	115
TLR4 biased small molecule modulators	112
Pharmacological modulation of respiratory control: Ampakines as a therapeutic strategy	112
Novel strategies and promising opportunities for targeted protein degradation: An innovative therapeutic approach to overcome cancer resistance	111
Myeloid cells in the era of cancer immunotherapy: Top 3 unanswered questions	110

Boron in cancer therapeutics: An overview	103
TAAR1 as an emerging target for the treatment of psychiatric disorders	99
Contribution of non-selective membrane channels and receptors in epilepsy	99
Harnessing and delivering microbial metabolites as therapeutics via advanced pharmaceutical approaches	99
Is the peroxisome proliferator-activated receptor gamma a putative target for epilepsy treatment? Current evidence and future perspectives	93
Time is of the essence: Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine	85
Sleep apnea and pulmonary hypertension: A riddle waiting to be solved	85
Endothelial function and dysfunction: Impact of sodium-glucose cotransporter 2 inhibitors	84
Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets	84
Sulfoconjugation of protein peptides and glycoproteins in physiology and diseases	83
Prostate Cancer Biomarkers: From diagnosis to prognosis and precision-guided therapeutics	83
Novel approaches to target fibroblast mechanotransduction in fibroproliferative diseases	80
Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization	80
Dysregulation of metabolic pathways in pulmonary fibrosis	80
The phospholipase A2 superfamily as a central hub of bioactive lipids and beyond	78
Targeting the p38α pathway in chronic inflammatory diseases: Could activation, not inhibition, be the appropriate therapeutic strategy?	77
PGRMC1: An enigmatic heme-binding protein	76
The pathomimetic oAβ25–35 model of Alzheimer's disease: Potential for screening of new therapeutic agents	75
Pharmacological treatment of cardiogenic shock – A state of the art review	75
Bispecific antibodies for the treatment of neuroblastoma	74
Recent advances in metabolism and toxicity of tyrosine kinase inhibitors	73
G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs)	73
Natural products that alleviate depression: The putative role of autophagy	72
Review: Sex-related differences in the treatment of cardiac arrhythmia	69
Corrigendum to “The role of CD71+ erythroid cells in the regulation of the immune response” [Pharmacology & Therapeutics 228 (2021) 107927]	68
Editorial Board	68
Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and induction), and clinical significance	67
Wnt signaling: A prospective therapeutic target for chronic pain	67
Interactions between NSAIDs, opioids and the gut microbiota - Future perspectives in the management of inflammation and pain	67
Therapeutic implications of impaired nuclear receptor function and dysregulated metabolism in Wilson's disease	66
Targeting Sirtuin1 to treat aging-related tissue fibrosis: From prevention to therapy	65
Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms	64
Stabilizing the neural barrier – A novel approach in pain therapy	62
DNA methylation in cell plasticity and malignant transformation in liver diseases	62
Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression	62
The role of microglia heterogeneity in synaptic plasticity and brain disorders: Will sequencing shed light on the discovery of new therapeutic targets?	62
A systematic review on renal effects of SGLT2 inhibitors in rodent models of diabetic nephropathy	61
Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters	60
CircRNAs as upstream regulators of miRNA//HMGA2 axis in human cancer	60
Entering the TiME machine: How age-related changes in the tumor immune microenvironment impact melanoma progression and therapy response	60
Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases	59
Signal transduction in primary cilia – analyzing and manipulating GPCR and second messenger signaling	59
Advances in pathogenesis and therapeutic strategies for osteoporosis	58
HDL-based therapeutics: A promising frontier in combating viral and bacterial infections	58
Addiction and the kynurenine pathway: A new dancing couple?	58
Autophagy inhibitors for cancer therapy: Small molecules and nanomedicines	58
Editorial Board	57
Noncoding RNA circuitry in melanoma onset, plasticity, and therapeutic response	57
Regulation of feeding and therapeutic application of bioactive peptides	56
Optimizing drug therapies in cardiac amyloidosis	55

The role of drug-metabolizing enzymes in synthetic lethality of cancer	55
Emerging roles of RNA ac4C modification and NAT10 in mammalian development and human diseases	54
17β-hydroxysteroid dehydrogenases in the progression of nonalcoholic fatty liver disease	53
In vitro functional assays as a tool to study new synthetic opioids at the μ-opioid receptor: Potential, pitfalls and progress	53
Drug repurposing for COVID-19: Approaches, challenges and promising candidates	53
Myeloperoxidase: Growing importance in cancer pathogenesis and potential drug target	53
Chemical diversity, traditional uses, and bioactivities of Rosa roxburghii Tratt: A comprehensive review	52
Endothelial shear stress signal transduction and atherogenesis: From mechanisms to therapeutics	52
Extracellular vesicles in cardiovascular disease: Biological functions and therapeutic implications	51
The therapeutic potential of Nrf2 inducers in chronic pain: Evidence from preclinical studies	50
Therapeutic targeting of DNA methylation alterations in cancer	50
MAS-related G protein-coupled receptors X (MRGPRX): Orphan GPCRs with potential as targets for future drugs	50
Editorial Board	49
Editorial Board	49
Bridging the gap: The endocannabinoid system as a functional fulcrum for benzodiazepines in a novel frontier of anxiety pharmacotherapy	49
Recent advances in riboflavin transporter RFVT and its genetic disease	49
Pathological changes in GPCR signal organisation: Opportunities for targeted therapies for triple negative breast cancer	48
Pharmacological potential of cyclic nucleotide signaling in immunity	48
MicroRNAs in drug addiction: Current status and future perspectives	48
Organic anion transporters in remote sensing and organ crosstalk	48
Cannabinoid receptor 1 ligands: Biased signaling mechanisms driving functionally selective drug discovery	47
Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation	46
CDNF and ER stress: Pharmacology and therapeutic possibilities	46
Emerging methods for and novel insights gained by absolute quantification of mitochondrial DNA copy number and its clinical applications	46
Musculoskeletal crosstalk in chronic obstructive pulmonary disease and comorbidities: Emerging roles and therapeutic potentials	46
Translating biased agonists from molecules to medications: Serotonin 5-HT1A receptor functional selectivity for CNS disorders	46
Integrins in cancer: Emerging mechanisms and therapeutic opportunities	45
Lactate acidosis and simultaneous recruitment of TGF-β leads to alter plasticity of hypoxic cancer cells in tumor microenvironment	45
A deep dive into UV-based phototherapy: Mechanisms of action and emerging molecular targets in inflammation and cancer	45
Update on treatment of abdominal pain in irritable bowel syndrome: A narrative review	45
The emerging science of Glioception: Contribution of glia in sensing, transduction, circuit integration of interoception	44
Immunotherapy for hepatocellular carcinoma: Recent advances and future targets	44
Pharmacological interventions for intraplaque neovascularization in atherosclerosis	43
The role and participation of immune cells in the endometrial tumor microenvironment	43
Consideration of albumin-mediated hepatic uptake for highly protein-bound anionic drugs: Bridging the gap of hepatic uptake clearance between in vitro and in vivo	43
Editorial Board	43
Tumor microenvironment as a therapeutic target in cancer	43
Neurobiological mechanisms of botulinum neurotoxin-induced analgesia for neuropathic pain	43
The natriuretic peptide system in heart failure: Diagnostic and therapeutic implications	43
Targeting cancer-associated fibroblasts: Challenges, opportunities and future directions	42
The tissue-specific transcriptional landscape underlines the involvement of endothelial cells in health and disease	42
G protein-coupled estrogen receptor biased signaling in health and disease	42
The (neuro)inflammatory system in anxiety disorders and PTSD: Potential treatment targets	42
Resolving inflammation by TAM receptor activation	42
Deliver the promise: RNAs as a new class of molecular entities for therapy and vaccination	42
Exploring the landscape of post-translational modification in drug discovery	41
Biased agonism in drug discovery: Is there a future for biased 5-HT1A receptor agonists in the treatment of neuropsychiatric diseases?	41
Annexin A1 in neurological disorders: Neuroprotection and glial modulation	40
Editorial Board	40
Potential targeting of the tumor microenvironment to improve cancer virotherapy	40
Molecular mechanisms of ferroptosis and their involvement in brain diseases	40
Attributes novel drug candidate: Constitutive GPCR signal bias mediated by purinergic receptors	40
Modulation of hyaluronan signaling as a therapeutic target in human disease	40
Experimental considerations for the assessment of in vivo and in vitro opioid pharmacology	39
Platelet lipid metabolism in vascular thrombo-inflammation	39
The role of osteoprotegerin (OPG) in fibrosis: its potential as a biomarker and/or biological target for the treatment of fibrotic diseases	39
Phosphorylation of nuclear receptors: Novelty and therapeutic implications	38
Extracellular vesicles in cancer diagnostics and therapeutics	38
Advances in anticancer alkaloid-derived metallo-chemotherapeutic agents in the last decade: Mechanism of action and future prospects	38
Development and clinical translation of P2X7 receptor antagonists: A potential therapeutic target in coronary artery disease?	38
Understanding the molecular bridges between the drugs and immune cell	38
Following the design path of isoform-selective Hsp90 inhibitors: Small differences, great opportunities	38
Editorial Board	37
Advances in the pathophysiology of atopic dermatitis revealed by novel therapeutics and clinical trials	37
Treating exuberant, non-resolving inflammation in the lung; Implications for acute respiratory distress syndrome and COVID-19	37
Early life adversities, psychopathologies and novel pharmacological strategies	37
Prolactin and pain of endometriosis	36
Roles of NLRC4 inflammasome in neurological disorders: Mechanisms, implications, and therapeutic potential	36
Role of phosphodiesterase 1 in the pathophysiology of diseases and potential therapeutic opportunities	36
Editorial Board	36
Targeting the Semaphorin3E-plexinD1 complex in allergic asthma	36
Editorial Board	36
Modulating glucocorticoid receptor actions in physiology and pathology: Insights from coregulators	35
Plant-derived nanovesicles and therapeutic application	35
The antidepressant actions of ketamine and its enantiomers	35
From bench to clinic: Emerging therapies for corneal scarring	35
Therapeutic antibodies – natural and pathological barriers and strategies to overcome them	35
Targeting myeloid-derived suppressor cells to enhance natural killer cell-based immunotherapy	34
Nanotechnology and nano-sized tools: Newer approaches to circumvent oncolytic adenovirus limitations	34
The essential role of docosahexaenoic acid and its derivatives for retinal integrity	34

Immune cells and their derived microRNA-enriched extracellular vesicles in nonalcoholic fatty liver diseases: Novel therapeutic targets	34
Resolution of inflammation: An organizing principle in biology and medicine	34
Signaling pathways in brain ischemia: Mechanisms and therapeutic implications	33
Molecular mechanisms and cardiovascular implications of cancer therapy-induced senescence	33
Bile acids and neurological disease	32
Editorial Board	32
Editorial Board	32
Biased signaling in drug discovery and precision medicine	32
Chloride channels in the lung: Challenges and perspectives for viral infections, pulmonary arterial hypertension, and cystic fibrosis	31
Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease: Challenges and research opportunities	30
Distinct mechanisms underlying therapeutic potentials of CD20 in neurological and neuromuscular disease	30
Benzamide derivative radiotracers targeting melanin for melanoma imaging and therapy: Preclinical/clinical development and combination with other treatments	30
Multitasking bamboo leaf-derived compounds in prevention of infectious, inflammatory, atherosclerotic, metabolic, and neuropsychiatric diseases	30
Endotheliopathy in the metabolic syndrome: Mechanisms and clinical implications	30
Gene and stem cell therapy for inherited cardiac arrhythmias	30
Treatment of overdose in the synthetic opioid era	30
Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics	30
Spotlight on plasticity-related genes: Current insights in health and disease	29
GLP-1 receptor agonists, are we witnessing the emergence of a paradigm shift for neuro-cardio-metabolic disorders?	29
Retina-directed gene therapy: Achievements and remaining challenges	29
Editorial Board	29
Current state and novel outlook on prevention and treatment of rising antibiotic resistance in urinary tract infections	29
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle	29
Mechanistic insights into medulloblastoma relapse	29
Anti-cancer activity of sustained release capsaicin formulations	29
Protoporphyrin IX-induced phototoxicity: Mechanisms and therapeutics	29
Icosapent ethyl in cardiovascular prevention: Resolution of inflammation through the eicosapentaenoic acid - resolvin E1 - ChemR23 axis	29
Resolution of inflammation in oral diseases	28
Targeting immunoproteasome in neurodegeneration: A glance to the future	28
Emerging roles of Glucagon like peptide-1 in the management of autoimmune diseases and diabetes-associated comorbidities	28
Oxytocin signaling in the treatment of drug addiction: Therapeutic opportunities and challenges	28
Assay design and development strategies for finding Hsp90 inhibitors and their role in human diseases	28
Clinical advances in oncolytic virotherapy for pediatric brain tumors	28
The cardiovascular effects of air pollution: Prevention and reversal by pharmacological agents	27
Metabolomics, metabolic flux analysis and cancer pharmacology	27
Microvascular basis of cognitive impairment in type 1 diabetes	27
A comprehensive review on pharmacokinetic mechanism of herb-herb/drug interactions in Chinese herbal formula	27
The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy	27
Lessons learned from 20 years of preclinical testing in pediatric cancers	27
Therapeutic PCSK9 targeting: Inside versus outside the hepatocyte?	27
The immune modifying effects of chemotherapy and advances in chemo-immunotherapy	27
Anticancer or carcinogenic? The role of estrogen receptor β in breast cancer progression	27
Artificial intelligence with mass spectrometry-based multimodal molecular profiling methods for advancing therapeutic discovery of infectious diseases	27
Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders	27
From exploring cancer and virus targets to discovering active peptides through mRNA display	26
PPARγ signaling in hepatocarcinogenesis: Mechanistic insights for cellular reprogramming and therapeutic implications	26
“RB-reactivator screening” as a novel cell-based assay for discoveries of molecular targeting agents including the first-in-class MEK inhibitor trametinib (trade name: Mekinist)	26
Therapeutic strategies for non-small cell lung cancer: Experimental models and emerging biomarkers to monitor drug efficacies	26
Antithrombotic therapy following transcatheter aortic valve intervention	26
CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases	26
The future of targeted kinase inhibitors in melanoma	26
Exploring the “Other” subfamily of HECT E3-ligases for therapeutic intervention	25
ThermoTRP channels in pain sexual dimorphism: new insights for drug intervention	25
Potential application of natural compounds in ischaemic stroke: Focusing on the mechanisms underlying “lysosomocentric” dysfunction of the autophagy-lysosomal pathway	25
Blood-brain barrier leakage in Alzheimer’s disease: From discovery to clinical relevance	25
Advances in understanding cancer-associated neurogenesis and its implications on the neuroimmune axis in cancer	25
Targeting hedgehog signaling in pancreatic ductal adenocarcinoma	25
A natural products solution to diabetic nephropathy therapy	24
Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications	24
Tissue-specific activation of insulin signaling as a potential target for obesity-related metabolic disorders	24
Efficacy and safety of transarterial chemoembolization combined with lenvatinib and PD-1 inhibitor in the treatment of advanced hepatocellular carcinoma: A meta-analysis	24
Therapeutic strategies to target connective tissue growth factor in fibrotic lung diseases	24
Sex differences in eicosanoid formation and metabolism: A possible mediator of sex discrepancies in cardiovascular diseases	24
Bile acid metabolism and signaling: Emerging pharmacological targets of dietary polyphenols	24
Insights into the results of Resmetirom trials: Can a thyroid hormone receptor agonist be the holy grail of MASH therapy?	23
Editorial Board	23
Editorial Board	23
Heterogeneity of cGMP signalling in tumour cells and the tumour microenvironment: Challenges and chances for cancer pharmacology and therapeutics	23
Sodium-glucose co-transporter 2 inhibitors in patients with chronic kidney disease	23
Retracing our steps: A review on autism research in children, its limitation and impending pharmacological interventions	23
Targeting the dysfunction of glutamate receptors for the development of novel antidepressants	23
Inflammation in kidney repair: Mechanism and therapeutic potential	23
The complex molecular pharmacology of the dopamine D2 receptor: Implications for pramipexole, ropinirole, and rotigotine	23
Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer	23
Pharmaceutical treatment of bone loss: From animal models and drug development to future treatment strategies	22
The unique function of p130Cas in regulating the bone metabolism	22
Impact of drug treatment and drug interactions in post-stroke epilepsy	22
Bioactive lipid regulation of platelet function, hemostasis, and thrombosis	22
Inter and intra-tumoral heterogeneity as a platform for personalized therapies in medulloblastoma	22
Novel strategies exploiting interleukin-12 in cancer immunotherapy	22
Functional hydrogels as therapeutic tools for spinal cord injury: New perspectives on immunopharmacological interventions	22
Probiotics: Potential novel therapeutics for microbiota-gut-brain axis dysfunction across gender and lifespan	22
TAS-102: A resurrected novel Fluoropyrimidine with expanding role in the treatment of gastrointestinal malignancies	22
CYP2J2-mediated metabolism of arachidonic acid in heart: A review of its kinetics, inhibition and role in heart rhythm control	22
The next frontier in ADME science: Predicting transporter-based drug disposition, tissue concentrations and drug-drug interactions in humans	22
Targeted treatment of alcoholic liver disease based on inflammatory signalling pathways	22
Editorial Board	21
Overview of the role of purinergic signaling and insights into its role in cancer therapy	21
Corrigendum to “Apical sodium-dependent bile acid transporter, drug target for bile acid related diseases and delivery target for prodrugs: Current and future challenges” [Pharmacology & Therapeut	21
Editorial Board	21
Cytochrome P450-derived fatty acid epoxides and diols in angiogenesis and stem cell biology	21
Editorial Board	21
Understanding the physiological role of NaV1.9: Challenges and opportunities for pain modulation	21
Targeting selective autophagy in CNS disorders by small-molecule compounds	21
The endocrine FGFs axis: A systemic anti-fibrotic response that could prevent pulmonary fibrogenesis?	21