OOIR: Observatory of International Research

Papers

(The H4-Index of Pharmacology & Therapeutics is 60. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
Tumor microenvironment as a therapeutic target in cancer	812
Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms	319
Idiopathic pulmonary fibrosis: Disease mechanisms and drug development	288
Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?	227
The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species	203
Resolution of inflammation: An organizing principle in biology and medicine	182
Advances in pathogenesis and therapeutic strategies for osteoporosis	176
The birth of artemisinin	176
Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression	170
Programming inflammatory cell death for therapy	138
Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics	135
Bile acid metabolism and signaling, the microbiota, and metabolic disease	131
The strategies and techniques of drug discovery from natural products	127
Therapeutic targets in lung tissue remodelling and fibrosis	127
Natural medicine in neuroprotection for ischemic stroke: Challenges and prospective	124
Targeting the NLRP3 inflammasome in cardiovascular diseases	118
Inflammation is a major regulator of drug metabolizing enzymes and transporters: Consequences for the personalization of drug treatment	117
Carcinogenesis: Failure of resolution of inflammation?	115
Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint	115
Traditional application and modern pharmacological research of Artemisia annua L.	106
Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics	104
Therapeutic potential of resveratrol against emerging respiratory viral infections	102
Evidence-based pharmacological treatment options for ADHD in children and adolescents	99
PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders	99
Molecular mechanisms of ferroptosis and their involvement in brain diseases	99

Drug repurposing for COVID-19: Approaches, challenges and promising candidates	97
The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy	95
Macrophage migration inhibitory factor (MIF): A multifaceted cytokine regulated by genetic and physiological strategies	93
Chinmedomics, a new strategy for evaluating the therapeutic efficacy of herbal medicines	93
Role of inflammatory chemokines in hypertension	86
Polyphenols and neuroprotection: Therapeutic implications for cognitive decline	85
Stepping forward in antibody-drug conjugate development	85
The natriuretic peptide system in heart failure: Diagnostic and therapeutic implications	85
Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms	84
Triple negative breast cancer (TNBC): Non-genetic tumor heterogeneity and immune microenvironment: Emerging treatment options	84
CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases	79
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle	79
Updates on community acquired pneumonia management in the ICU	78
The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention	78
Kynurenine emerges from the shadows – Current knowledge on its fate and function	78
Current developments of targeting the p53 signaling pathway for cancer treatment	77
A decade of cell death studies: Breathing new life into necroptosis	76
Pharmacological treatment of eating disorders, comorbid mental health problems, malnutrition and physical health consequences	74
Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain	73
The Role of non-coding RNAs in colorectal cancer, with a focus on its autophagy	73
Tumor organoid models in precision medicine and investigating cancer-stromal interactions	73
Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers	71
Targeting post-translational histone modifying enzymes in glioblastoma	70
Sirtuins' control of autophagy and mitophagy in cancer	68
Extracellular vesicles in cardiovascular disease: Biological functions and therapeutic implications	68
Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors	67
Immune activities of polysaccharides isolated from Lycium barbarum L. What do we know so far?	66
Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases	65
Double-edged roles of protein tyrosine phosphatase SHP2 in cancer and its inhibitors in clinical trials	65
Macrophage immunometabolism in inflammatory bowel diseases: From pathogenesis to therapy	65
Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications	62
Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases	62
TGFβ-Directed Therapeutics: 2020	61
G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects	61
Particulate matter air pollutants and cardiovascular disease: Strategies for intervention	61
Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression	60