OOIR: Observatory of International Research

Papers

(The TQCC of Drug and Chemical Toxicology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Investigation of the role of K _ATP channels in the cytotoxic effect of cypermethrin on rat-derived aortic smooth muscle cells	30
Population pharmacokinetics and pharmacodynamics of L-asparaginase and its impact on the development of pancreatitis and hypersensitivity reactions in children with leukemia under treatment	25
Antioxidant capacity, acute and sub-acute oral toxicity, and in vivo anti-inflammatory effects of Tetradenia riparia hydroalcoholic extrac	23
Changes in hormones, Leukocyte Telomere Length (LTL), and p16^INK4a expression in SM-exposed individuals in favor of the cellular senescence	20
Gastroprotective mechanism of Talinum triangulare on ethanol-induced gastric ulcer in Wistar rats via inflammatory, antioxidant, and H	19
In vitro evaluation of the selective cytotoxicity and genotoxicity of three synthetic ortho -nitrobenzyl derivatives in human cancer cell lines, with	18
The ameliorative effect of rosmarinic acid and epigallocatechin gallate against doxorubicin-induced genotoxicity	18
Non-permitted food colorants induced neurotoxicity in cerebellum of rat brain	18
Amelioration of metabolic disorders in H9C2 cardiomyocytes induced by PM _2.5 treated with vitamin C	17
Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by α-naphthylthiourea	17
Oxidative stress and inflammatory markers in streptozotocin-induced acute and subacute toxicity response	16
Evaluating Water bitter leaf (Struchium sparganophora) and Scent Leaf (Ocimum gratissimum)extracts as sources of nutraceuticals against manganese-induced toxicity in fruit fly model	16
Unraveling the hepatoprotective and anti-pancreatic cancer potential of Caralluma europaea : a comprehensive in vivo, in vitro and in sili	15
Genotoxic effects of gadobutrol and gadoversetamide active substances used in magnetic resonance imaging in human peripheral lymphocytesin vitro	15
Effect of chlorpyrifos on some biochemical changes in Cyprinus carpio: the protective effect of ellagic acid	15
Synergistic hepatoprotective effects of ω-3 and ω-6 fatty acids from Indian flax and sesame seed oils against CCl ₄ -induced oxidative stress-mediated liver damage i	14
Content of potentially toxic elements (PTEs) in coffee and coffee-based products: a meta-analysis study, Systematic review, and health risk assessment	13
Linolenic acid stimulates eryptosis and hemolysis through oxidative stress and CK1α/MLKL: protective role of melatonin, urea, and polyethylene glycol	13
Evaluation of acute and 28-day repeated dose toxicity of Tolypocladium sinense soft capsule in Sprague-Dawley rats	13
Screening and toxicity evaluation of natural compounds as adenosine 2a and 2b receptor ligands: insights from molecular docking, dynamics, and ADMET analysis	12
Pelargonidin ameliorates reserpine-induced neuronal mitochondrial dysfunction and apoptotic cascade: a comparative in vivo study	12
NO-mediated DNA damage induced by polystyrene nanoparticles triggers program cell death in mesenchymal stem cells	12
Investigation of oxidative, inflammatory and apoptotic effects of favipiravir use alone and combined with vitamin C on brain tissue of elderly rats	12
Acute and sub-acute toxicological evaluation of a bioactive compound mixture in healthy Wistar rats	12
Co-administration of thymol and sulfoxaflor impedes the expression of reproductive toxicity in male rats	12

Toxicity of pesticide cocktails in amphibian larvae: understanding the impact of agricultural activity on aquatic ecosystems in the Salado River basin, Argentina	11
Tauroursodeoxycholic acid suppresses biliary epithelial cell apoptosis and endoplasmic reticulum stress by miR-107/NCK1 axis in a FXR-dependent manner	11
Assessment of morin hydrate as a renal protective agent in rats subjected to methotrexate-induced nephrotoxicity	10
TiO ₂ nanoparticles: green synthesis, characterization, and investigation of antimicrobial properties, and developmental toxicity in zebrafish ( Danio	10
Protective effect of dexpanthenol against methotrexate-induced liver oxidative toxicity in rats	10
Toothpastes for children and their detergent contents affect molecular mechanisms of odontogenesis in zebrafish embryos	10
Fumaric acid protects rats from ciprofloxacin-provoked depression through modulating TLR4, Nrf-2, and p190-rho GTP	10
Saffron stigma extract and crocin play an important neuroprotective role in therapeutic measures against benzo[a]pyrene-induced behavioral alterations in zebrafish	10
Renal tubular response to titanium dioxide nanoparticles exposure	10
Naringenin mitigates cadmium-induced cell death, oxidative stress, mitochondrial dysfunction, and inflammation in KGN cells by regulating the expression of sirtuin-1	10
Silymarin attenuates cobalt chloride-induced redox imbalance and cardio-renal dysfunctions in rats	10
Modulatory effect of myricitrin against chromosome instability and cytostasis induced by bleomycin and oxaliplatin in CHO-K1 cells	10
Antioxidant and in vitro cytogenotoxic properties of Amburana cearensis (Allemão) A.C.Sm. leaf extract	10
Preventive treatment with sodium para-aminosalicylic acid inhibits manganese-induced apoptosis and inflammation via the MAPK pathway in rat thalamus	10
Toxicity study of compound honeysuckle moisturizing Chinese herbal extract by oral gavage for 13 weeks in sprague dawley rats	10
Study on the acute and subchronic oral toxicity of Calculus Bovis Sativus in rats	9
Effect of adenosine triphosphate on methylphenidate-induced oxidative and inflammatory kidney damage in rats	9
Damage to the sarcoplasmic reticulum by venom of the Mexican black-tailed rattlesnake ( Crotalus molossus nigrescens ): inhibition of the Ca ²⁺	9
Probiotics modulation of the endotoxemic effect on the gut and liver of the lipopolysaccharide challenged mice	9
Single acute and repeated subacute toxicity evaluations of Annona atemoya leaf extract with in vitro anti-inflammatory potential	9
Pentoxifylline inhibits phosgene-induced lung injury via improving hypoxia	9
Cyclosporine-A induced cytotoxicity within HepG2 cells by inhibiting PXR mediated CYP3A4/CYP3A5/MRP2 pathway	8
Evaluation of toxicological profile of omeprazole degradation impurities in an intravenous drug product: omeprazole-sulfone and omeprazole-N-oxide	8
Prognostic value of systemic immune-inflammation index and monocyte-to-HDL-cholesterol ratio in early cardio-cerebral complications in elderly patients with acute severe carbon monoxide poisoning	8
Toxicological assays in the evaluation of safety assessment of fibrinolytic enzymes	8
Ethyl pyruvate attenuates cisplatin-induced ovarian injury in rats via activating Nrf2 pathway	8
Long term integrated biomarker responses in freshwater African catfish Clarias gariepinus exposed to a new brand of herbicide fluazifop-p-butyl	8
Uncoupling as initiating event in mitochondrial dysfunction after diuron exposure	7
Computational modeling ( in silico ) methods combined with ecotoxicological experiments ( in vivo ) to predict the environmental risks of	7
Safety assessment of Wuzhuyu decoction extract: acute and subacute oral toxicity studies in rats	7
Assessment of the toxicity of different antiretroviral drugs and their combinations on Sertoli and Leydig cells	7
Salvianolic acid A suppresses CCl₄-induced liver fibrosis through regulating the Nrf2/HO-1, NF-κB/IκBα, p38 MAPK, and JAK1/STAT3 signaling pathways	7
Pre-clinical and cellular safety assessment of oral administered DHA rich microalgae oil from Schizochytrium sp. (Strain ATCC-20889): acute, sub-chronic and genotoxicity	7
Both acute glyphosate and the aminomethylphosphonic acid intoxication decreased the acetylcholinesterase activity in rat hippocampus, prefrontal cortex and gastrocnemius muscle	7
Kidney damage following a 90-day subchronic inhalation exposure to HTP aerosol in SD rats	7
Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats	7
Chronic levamisole exposure in male rats alters sexual behavior and induces apoptosis in the testis	7
Phycocyanin improved alcohol-induced hepatorenal toxicity and behavior impairment in Wistar rats	7
Effect ofMoringa oleiferaleaf extract on valproate-induced oxidative damage in muscle	7
B-Raf inhibitor vemurafenib counteracts sulfur mustard-induced epidermal impairment through MAPK/ERK signaling	7
Assessment of the effect of sodium tetraborate on oxidative stress, inflammation, and apoptosis in lead-induced nephrotoxicity	7
Metformin ameliorates cardiopulmonary toxicity induced by chlorpyrifos	7
Omeprazole induces profibrotic gene expression in rat kidney: implication of TGF-β/Smad signaling pathway	6
Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats	6
Fluoroquinolone antibiotics in the aquatic environment: environmental distribution, the research status and eco-toxicity	6
Curcumin improves the ability of donepezil to ameliorate memory impairment in Drosophila melanogaster: involvement of cholinergic and cnc/Nrf2-redox systems	6
Computational design and evaluation of low-toxicity saquinavir analogues targeting the catalytic dyad and oxyanion-hole loop of SARS-CoV-2 Mpro: insights from ensemble docking, molecular dynamics, dyn	6
A comparison of the potential of melatonin and tryptophan to ameliorate CCl ₄ -induced hepatic and renal toxicity in Wistar rats	6
Comparative cytotoxicity induced by parabens and their halogenated byproducts in human and fish cell lines	6
Effects of methiopropamine on cognitive function and monoaminergic systems in mice	6

Physcion alleviates cisplatin-induced apo in HK-2 cells by activating the apo signaling for treating acute kidney injury: Integrating network pharmacology and informatics	6
Nigella sativa oil reduces oxidative/nitrosative stress in the salivary gland of rats exposed to total cranial irradiation	6
Eight-year epidemiological study for drug poisoning in Qassim, Saudi Arabia, 2008–2015	6
Genotoxic and genoprotective effects of phytoestrogens: a systematic review	6
Acute and 13 weeks subchronic toxicological evaluation of the flavonoid-rich extract of Sophora flavescens	6
Cardiotoxicity induced by xanthatin via activating apoptosis and ERS pathways in zebrafish	5
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats	5
Acute exposure to environmentally relevant concentrations of pharmaceutical pollutants induces neurobehavioral toxicity in zebrafish ( Danio rerio )	5
A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose- and streptozotocin-induced rats: comparison with antioxidant stobadine	5
Glyphosate in the Iberian Peninsula: Evaluating risks to Iberian wildlife	5
Evaluation of XQ528 tartrate on embryo-fetus developmental toxicity in SD rats and genotoxicity	5
Exploring health beneficial effects of poisonous mushroom Paxillus involutus Batsch Fr.	5
Hydromorphone impurity 2,2-bishydromorphone does not exert mutagenic and clastogenic properties via in silico QSAR prediction and in vitro Ames and micronucleus test	5
Evaluation of antifungal activity, mechanisms of action and toxicological profile of the synthetic amide 2-chloro- N -phenylacetamide	5
Oxidative stress and toxicity induced by copper and zinc oxide nanoparticles in liver and kidney tissues of male mice	5
Effects of acetaminophen exposure on behavior and erythrocyte nuclear morphology of juvenile Oreochromis niloticus	5
Induced oxidative stress and apoptosis by 1-bromopropane in SH-SY5Y cells correlates with inhibition of Nrf2 function	5
Reproductive and developmental toxicity of α-terpineol in Wistar rats	5
Phytochemical composition, cytotoxicity, antioxidant and antimicrobial responses of Lavandula dentata L. grown under different levels of heavy metals stress condition	5
Single and repeat-dose toxicity and local tolerance assessment of newly developed oil emulsion adjuvant formulations for veterinary purposes	5
Exploring the toxicity profile of coriander ( C. sativum L.) essential oil: implications for translational toxicological research	5
Co-administered chitosan and ivy leaf extract reduce deltamethrin-induced testicular toxicity	5
Artemisia vulgaris L., Artemisia alba Turra and their constituents reduce mitomycin C-induced genomic instability in human peripheral blood lymphocyte	5
Preclinical safety profile of RC88-ADC：a novel mesothelin-targeted antibody conjugated with Monomethyl auristatin E	5
In vitro cytogenotoxic evaluation of aripiprazole on human peripheral lymphocytes and computational molecular docking analysis	5
Effects of burnt tire-ash on Na⁺/K⁺, Ca²⁺-ATPase, serum immunoglobulin and brain acetylcholinesterase activities in clarias gariepinus (Burchell, 1822)	5
New oxomethacrylate and acetamide: synthesis, characterization, and their computational approaches: molecular docking, molecular dynamics, and ADME analyses	5
In vitro and in vivo genotoxicity assessments of Ficus erecta Thunb. leaves extract support its functional and pharmace	5
Toxicogenetic profile of the monoterpene alpha-terpineol on normal and tumor eukaryotic cells	5
Potential neuroprotective effects of 2-hydroxypropyl-β cyclodextrin against amyloid β (1-42)-induced neurotoxicity on the rat hippocampus	5
MiR-27b-3p ameliorates DOX-induced cardiotoxicity by suppressing myocardial inflammation and oxidative stress in mice and cardiomyocytes	5
Sildenafil aggravates adriamycin-induced testicular toxicity in rats; a preliminary investigation	5
Impact of benzophenone-2 exposure on the reproductive outcomes in adult female mice	5