OOIR: Observatory of International Research

Papers

(The TQCC of Drug and Chemical Toxicology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Investigation of the role of K _ATP channels in the cytotoxic effect of cypermethrin on rat-derived aortic smooth muscle cells	29
Population pharmacokinetics and pharmacodynamics of L-asparaginase and its impact on the development of pancreatitis and hypersensitivity reactions in children with leukemia under treatment	24
Unraveling the hepatoprotective and anti-pancreatic cancer potential of Caralluma europaea : a comprehensive in vivo, in vitro and in sili	22
Oxidative stress and inflammatory markers in streptozotocin-induced acute and subacute toxicity response	20
Boldine activates Nrf2/ARE signaling to alleviate 5-fluorouracil-induced apoptosis, oxidative stress and inflammation in liver tissue of rats	19
The ameliorative effect of rosmarinic acid and epigallocatechin gallate against doxorubicin-induced genotoxicity	19
Synthesis and multidimensional investigation of a tetra-substituted imidazole derivative: Spectroscopy, DFT/NLO properties, toxicity analysis, molecular docking, and dynamics simulation	17
Changes in hormones, Leukocyte Telomere Length (LTL), and p16^INK4a expression in SM-exposed individuals in favor of the cellular senescence	17
Lipid profile, toxicity, and antioxidant potential of flavonoid-rich babassu mesocarp extract after simulated human digestion	17
Amelioration of metabolic disorders in H9C2 cardiomyocytes induced by PM _2.5 treated with vitamin C	17
The effect on paraoxonase and arylesterase activities of bee pollen against deltamethrin in Cyprinus carpio	16
Antioxidant capacity, acute and sub-acute oral toxicity, and in vivo anti-inflammatory effects of Tetradenia riparia	15
Gastroprotective mechanism of Talinum triangulare on ethanol-induced gastric ulcer in Wistar rats via inflammatory, antioxidant, and H	15
In vitro evaluation of the selective cytotoxicity and genotoxicity of three synthetic ortho -nitrobenzyl derivatives in human cancer cell lines, with	14
Impact of placental polycyclic aromatic hydrocarbons accumulation on neonatal birth outcomes	14
Co-administration of thymol and sulfoxaflor impedes the expression of reproductive toxicity in male rats	14
Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by α-naphthylthiourea	14
Toxicity of pesticide cocktails in amphibian larvae: understanding the impact of agricultural activity on aquatic ecosystems in the Salado River basin, Argentina	13
Tauroursodeoxycholic acid suppresses biliary epithelial cell apoptosis and endoplasmic reticulum stress by miR-107/NCK1 axis in a FXR-dependent manner	13
Evaluation of acute and 28-day repeated dose toxicity of Tolypocladium sinense soft capsule in Sprague-Dawley rats	13
Investigation of oxidative, inflammatory and apoptotic effects of favipiravir use alone and combined with vitamin C on brain tissue of elderly rats	13
Evaluation of therapeutic effects of royal jelly versus Nigella sativa oil on some brain areas affected by acute methanol poisoning in rats	12
Acute and sub-acute toxicological evaluation of a bioactive compound mixture in healthy Wistar rats	12
Phenytoin as an emerging pollutant on non-target aquatic invertebrates: effects on Lamellidens marginalis	12
N-nitrosodimethylamine increased glucose production by promoting hyperglycemia in hepatocyte via AMPK signaling pathway in vivo and in vitro	11

Linolenic acid stimulates eryptosis and hemolysis through oxidative stress and CK1α/MLKL: protective role of melatonin, urea, and polyethylene glycol	11
NO-mediated DNA damage induced by polystyrene nanoparticles triggers program cell death in mesenchymal stem cells	11
Screening and toxicity evaluation of natural compounds as adenosine 2a and 2b receptor ligands: insights from molecular docking, dynamics, and ADMET analysis	11
Assessment of morin hydrate as a renal protective agent in rats subjected to methotrexate-induced nephrotoxicity	11
Content of potentially toxic elements (PTEs) in coffee and coffee-based products: a meta-analysis study, Systematic review, and health risk assessment	10
Probiotics modulation of the endotoxemic effect on the gut and liver of the lipopolysaccharide challenged mice	10
Silymarin attenuates cobalt chloride-induced redox imbalance and cardio-renal dysfunctions in rats	10
Aspirin’s therapeutic mechanism against diesel particulate matter-induced lung injury revealed by network pharmacology and experimental models	10
Modulatory effect of myricitrin against chromosome instability and cytostasis induced by bleomycin and oxaliplatin in CHO-K1 cells	9
Naringenin mitigates cadmium-induced cell death, oxidative stress, mitochondrial dysfunction, and inflammation in KGN cells by regulating the expression of sirtuin-1	9
Fumaric acid protects rats from ciprofloxacin-provoked depression through modulating TLR4, Nrf-2, and p190-rho GTP	9
TiO ₂ nanoparticles: green synthesis, characterization, and investigation of antimicrobial properties, and developmental toxicity in zebrafish ( Danio	9
Toothpastes for children and their detergent contents affect molecular mechanisms of odontogenesis in zebrafish embryos	9
Saffron stigma extract and crocin play an important neuroprotective role in therapeutic measures against benzo[a]pyrene-induced behavioral alterations in zebrafish	9
Toxicity study of compound honeysuckle moisturizing Chinese herbal extract by oral gavage for 13 weeks in sprague dawley rats	9
Protective effect of dexpanthenol against methotrexate-induced liver oxidative toxicity in rats	8
Study on the acute and subchronic oral toxicity of Calculus Bovis Sativus in rats	8
Long term integrated biomarker responses in freshwater African catfish Clarias gariepinus exposed to a new brand of herbicide fluazifop-p-butyl	8
Pentoxifylline inhibits phosgene-induced lung injury via improving hypoxia	8
Ethyl pyruvate attenuates cisplatin-induced ovarian injury in rats via activating Nrf2 pathway	8
Single acute and repeated subacute toxicity evaluations of Annona atemoya leaf extract with in vitro anti-inflammatory potential	8
Damage to the sarcoplasmic reticulum by venom of the Mexican black-tailed rattlesnake ( Crotalus molossus nigrescens ): inhibition of the Ca ²⁺	8
Renal tubular response to titanium dioxide nanoparticles exposure	8
Toxicity of elemental selenium and selenium substances after pulmonary exposure; and environmental and occupational air concentrations: a review	8
Kidney damage following a 90-day subchronic inhalation exposure to HTP aerosol in SD rats	7
Metabolomics reveals formonetin mitigates neurotoxicity of CL-20 on neuron cells	7
Prognostic value of systemic immune-inflammation index and monocyte-to-HDL-cholesterol ratio in early cardio-cerebral complications in elderly patients with acute severe carbon monoxide poisoning	7
Assessment of the effect of sodium tetraborate on oxidative stress, inflammation, and apoptosis in lead-induced nephrotoxicity	7
Carvacrol alleviates hepatorenal apoptosis in rats following exposure to lambda-cyhalothrin by targeting the Trx1/Prx1/Bcl2 pathway: in vivo and molecula	7
Effect of adenosine triphosphate on methylphenidate-induced oxidative and inflammatory kidney damage in rats	7
Pharmacological synergistic multi-target of Curcuma longa compounds to minimise the ototoxic effects and resistance of cisplatin in ovarian cancer treatm	7
Toxicological assays in the evaluation of safety assessment of fibrinolytic enzymes	7
Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats	7
Assessment of the toxicity of different antiretroviral drugs and their combinations on Sertoli and Leydig cells	7
Cyclosporine-A induced cytotoxicity within HepG2 cells by inhibiting PXR mediated CYP3A4/CYP3A5/MRP2 pathway	7
Dose-dependent nephrotoxicity of hexaconazole following subchronic exposure in Swiss albino mice	7
Safety assessment of Wuzhuyu decoction extract: acute and subacute oral toxicity studies in rats	7
Evaluation of toxicological profile of omeprazole degradation impurities in an intravenous drug product: omeprazole-sulfone and omeprazole-N-oxide	7
Comparative cytotoxicity induced by parabens and their halogenated byproducts in human and fish cell lines	6
Role of endoplasmic reticulum stress in di(2-ethylhexyl) phthalate–induced renal toxicity and its amelioration by 4-phenylbutyric acid	6
Silymarin ameliorates post-weaning bisphenol A exposure-induced cardiotoxicity via suppression of TLR4/VCAM signaling in male Wistar rats	6
Chronic levamisole exposure in male rats alters sexual behavior and induces apoptosis in the testis	6
Physcion alleviates cisplatin-induced apo in HK-2 cells by activating the apo signaling for treating acute kidney injury: Integrating network pharmacology and informatics	6
Eight-year epidemiological study for drug poisoning in Qassim, Saudi Arabia, 2008–2015	6
Computational modeling ( in silico ) methods combined with ecotoxicological experiments ( in vivo ) to predict the environmental risks of	6
Effect ofMoringa oleiferaleaf extract on valproate-induced oxidative damage in muscle	6
Metformin ameliorates cardiopulmonary toxicity induced by chlorpyrifos	6
Nigella sativa oil reduces oxidative/nitrosative stress in the salivary gland of rats exposed to total cranial irradiation	6
Acute and subacute toxicity of ethanol leaf extract of Urtica simensis Hochst. ex A. Rich in rats	6
Curcumin improves the ability of donepezil to ameliorate memory impairment in Drosophila melanogaster: involvement of cholinergic and cnc/Nrf2-redox systems	6

Effects of methiopropamine on cognitive function and monoaminergic systems in mice	6
Fluoroquinolone antibiotics in the aquatic environment: environmental distribution, the research status and eco-toxicity	6
Phycocyanin improved alcohol-induced hepatorenal toxicity and behavior impairment in Wistar rats	6
Uncoupling as initiating event in mitochondrial dysfunction after diuron exposure	6
Pre-clinical and cellular safety assessment of oral administered DHA rich microalgae oil from Schizochytrium sp. (Strain ATCC-20889): acute, sub-chronic and genotoxicity	6
A comparison of the potential of melatonin and tryptophan to ameliorate CCl ₄ -induced hepatic and renal toxicity in Wistar rats	6
Both acute glyphosate and the aminomethylphosphonic acid intoxication decreased the acetylcholinesterase activity in rat hippocampus, prefrontal cortex and gastrocnemius muscle	6
Genotoxic and genoprotective effects of phytoestrogens: a systematic review	6
Omeprazole induces profibrotic gene expression in rat kidney: implication of TGF-β/Smad signaling pathway	6
In vivo and in silico toxicity profiling of a novel 1,5-benzodiazepine derivative	5
Exploring the toxicity profile of coriander ( C. sativum L.) essential oil: implications for translational toxicological research	5
Glyphosate in the Iberian Peninsula: Evaluating risks to Iberian wildlife	5
Computational design and evaluation of low-toxicity saquinavir analogues targeting the catalytic dyad and oxyanion-hole loop of SARS-CoV-2 Mpro: insights from ensemble docking, molecular dynamics, dyn	5
In vitro and in vivo genotoxicity assessments of Ficus erecta Thunb. leaves ext	5
A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose- and streptozotocin-induced rats: comparison with antioxidant stobadine	5
Evaluation of plasticizer toxicity effects and mechanisms in gastric cancer based on network toxicology and molecular docking	5
Evaluation of XQ528 tartrate on embryo-fetus developmental toxicity in SD rats and genotoxicity	5
Single and repeat-dose toxicity and local tolerance assessment of newly developed oil emulsion adjuvant formulations for veterinary purposes	5
Protective potential of crocin against cadmium-induced oxidative pancreatitis and liver injury in female rats	5
Potential neuroprotective effects of 2-hydroxypropyl-β cyclodextrin against amyloid β (1-42)-induced neurotoxicity on the rat hippocampus	5
Phytochemical composition, cytotoxicity, antioxidant and antimicrobial responses of Lavandula dentata L. grown under different levels of heavy metals stress condition	5
Reproductive and developmental toxicity of α-terpineol in Wistar rats	5
Exploring the toxicity mechanisms of acetyl tributyl citrate in premature ovarian insufficiency via network toxicology and molecular docking	5
Interest of biochemical monitoring of liver function for patients under anti-tuberculosis treatment	5
Co-administered chitosan and ivy leaf extract reduce deltamethrin-induced testicular toxicity	5
MiR-27b-3p ameliorates DOX-induced cardiotoxicity by suppressing myocardial inflammation and oxidative stress in mice and cardiomyocytes	5
Toxicogenetic profile of the monoterpene alpha-terpineol on normal and tumor eukaryotic cells	5
Exploring health beneficial effects of poisonous mushroom Paxillus involutus Batsch Fr.	5
Heavy metal mixture induced hippocampal toxicity involve biometal accumulation, increase in oxidative stress, inflammation, and caspase-3 activation in rats via Nrf-2/HO-1/BDNF pathway	4
Effects of acetaminophen exposure on behavior and erythrocyte nuclear morphology of juvenile Oreochromis niloticus	4
Assessment of differences in urinary heavy metal concentrations and environmental factors between children with autism spectrum disorder and neurotypical controls	4
Integrating network toxicology and molecular dynamics simulations to unveil the pathogenic mechanism of benzyl butyl phthalate in atopic dermatitis	4
Impact of benzophenone-2 exposure on the reproductive outcomes in adult female mice	4
Xenobiotic modalities impacting the thyroid 3H framework of hormonogenesis, homeostasis, and human health	4
Pharmacological and toxicological effects of paracetamol: current knowledge and a review	4
Synergistic hepatoprotection by supplementing Saussurea costus (falc.) lipsch and Glycyrrhiza glabra L. in combination against Diethylnitr	4
Acute and subacute dermal toxicity analysis of film forming topical spray of meloxicam: in vitro and in vivo	4
Potential protective effects of Acacia nilotica (L.) against gentamicin - induced nephrotoxicity by suppressing renal redox imbalance, inflammatory stress and caspase-de	4
Hepatoprotective effect of methanol fruit extract of Punica granatum L in highly active antiretroviral therapy-induced toxicity in Wistar rats	4
Di (2-ethyl hexyl) phthalate and its metabolite-induced metabolic syndrome: a review of molecular mechanisms	4
In vitro screening of genotoxicity and mutagenicity of pyriproxyfen in human lymphocytes and Salmonella typhimurium TA98 and TA100 strains	4
Cardiotoxicity induced by xanthatin via activating apoptosis and ERS pathways in zebrafish	4
New oxomethacrylate and acetamide: synthesis, characterization, and their computational approaches: molecular docking, molecular dynamics, and ADME analyses	4
In vitro cytogenotoxic evaluation of aripiprazole on human peripheral lymphocytes and computational molecular docking analysis	4
Dermatoprotective effect of Moringa oleifera leaf extract on sodium valproate-induced skin damage in rats	4
Synthesis, in vivo, in silico toxicological evaluation, and safety assessment of novel methyl 4-amino-1,9b-dihydrochromeno[3,4-c] pyrrole-1-carboxylate	4
Mandarin peel ethanolic extract attenuates diclofenac sodium induced hepatorenal toxicity in rats by mitigating oxidative stress and inflammation	4
Protective effects of royal jelly and Echinacea against moxifloxacin-induced renal and hepatic injury in rats	4
Mechanistic study of copper oxide, zinc oxide, cadmium oxide, and silver nanoparticles-mediated toxicity on the probiotic Lactobacillus reuteri	4
Further insights into the impact of rebamipide on gentamicin-induced nephrotoxicity in rats: modulation of SIRT1 and β-catenin/cyclin D1 pathways	4
Possible genotoxic effects of dapagliflozin using SMART and comet tests, and behavioral toxicity in Drosophila melanogaster	4
Long-term toxicity of fluoroquinolones: a comprehensive review	4
Correction	4
Oxidative stress and toxicity induced by copper and zinc oxide nanoparticles in liver and kidney tissues of male mice	4
Evaluation of antifungal activity, mechanisms of action and toxicological profile of the synthetic amide 2-chloro- N -phenylacetamide	4
Artemisia vulgaris L., Artemisia alba Turra and their constituents reduce mitomycin C-induced genomic instability in human peripheral blood lymphocyte	4
Induced oxidative stress and apoptosis by 1-bromopropane in SH-SY5Y cells correlates with inhibition of Nrf2 function	4
Acute exposure to environmentally relevant concentrations of pharmaceutical pollutants induces neurobehavioral toxicity in zebrafish ( Danio rerio )	4
Acute toxicity and biodistribution assessment of quantum dots conjugated to lectins from Schinus terebinthifolia leaves (SteLL) and Punica granatum	4
Ferroptosis: action and mechanism of chemical/drug-induced liver injury	4
In-silico toxicity assessment of polychlorinated naphthalenes in water ecosystem by Monte Carlo-based QSAR studies	4
Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate	4