OOIR: Observatory of International Research

Papers

(The TQCC of Drug and Chemical Toxicology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Chemical characterization of tobacco-free “modern” oral nicotine pouches and their position on the toxicant and risk continuums	45
Formaldehyde toxicity reports from in vitro and in vivo studies: a review and updated data	35
Nutritional supplementation of gallic acid ameliorates Alzheimer-type hippocampal neurodegeneration and cognitive impairment induced by aluminum chloride exposure in adult Wistar rats	28
Nephroprotective effect of ferulic acid on gentamicin-induced nephrotoxicity in female rats	22
Zingerone protects liver and kidney tissues by preventing oxidative stress, inflammation, and apoptosis in methotrexate-treated rats	21
Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish	20
Evaluation of genotoxicity induced by herbicide pendimethalin in fresh water fish Clarias batrachus (linn.) and possible role of oxidative stress in induced DNA damage	19
Characterization and neuroprotective properties of alkaloid extract of Vernonia amygdalina Delile in experimental models of Alzheimer’s disease	18
The protective effect of Morin against ifosfamide-induced acute liver injury in rats associated with the inhibition of DNA damage and apoptosis	18
In-vivo and in-silico toxicity studies of daidzein: an isoflavone from soy	17
Attenuation of lipid metabolic abnormalities, proinflammatory cytokines, and matrix metalloproteinase expression by biochanin-A in isoproterenol-induced myocardial infarction in rats	16
Escin attenuates oxidative damage, apoptosis and lipid peroxidation in a model of cyclophosphamide-induced liver damage	16
Toxicological impact of sodium benzoate on inflammatory cytokines, oxidative stress and biochemical markers in male Wistar rats	16
Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats	15
Linalool exhibits therapeutic and protective effects in a rat model of doxorubicin-induced kidney injury by modulating oxidative stress	15
Selenium and L-carnitine protects from valproic acid-Induced oxidative stress and mitochondrial damages in rat cortical neurons	15
Protection of CCl₄-induced hepatic and renal damage by linalool	15
Hepatoprotective effect of Raspberry ketone and white tea against acrylamide-induced toxicity in rats	14
The comparison of the effect of Origanum vulgare L. extract and vitamin C on the gentamycin-induced nephrotoxicity in rats	14
Hepatoprotective effect of Ginkgo biloba extract against methotrexate-induced hepatotoxicity via targeting STAT3/miRNA-21 axis	14
The outbreak of methanol intoxication during COVID-19 pandemic: prevalence of brain lesions and its predisposing factors	13
Melatonin modulates copper-induced anxiety-like, depression-like and memory impairments by acting on hippocampal oxidative stress in rat	13
Miconazole and terbinafine induced reactive oxygen species accumulation and topical toxicity in human keratinocytes	13
Benzo(a)pyrene affects proliferation with reference to metabolic genes and ROS/HIF-1α/HO-1 signaling in A549 and MCF-7 cancer cells	13
Brazil nut prevents oxidative DNA damage in type 2 diabetes patients	12

The protective effect of fluted pumpkin seeds against atrazine-induced testicular injury	12
Ellagic acid alleviates clozapine‑induced oxidative stress and mitochondrial dysfunction in cardiomyocytes	12
Linalool reverses benzene-induced cytotoxicity, oxidative stress and lysosomal/mitochondrial damages in human lymphocytes	12
Acute toxic effects of chlorpyrifos on pseudobranchial neurosecretory system, brain regions and locomotory behavior of an air-breathing catfish, Heteropneustes fossilis (Bloch 1794)	12
Placental levels of polycyclic aromatic hydrocarbons (PAHs) and their association with birth weight of infants	12
Borassus flabellifer haustorium extract prevents pro-oxidant mediated cell death and LPS-induced inflammation	12
Evaluation of the acute toxic effect of azoxystrobin on non-target crayfish (Astacus leptodactylus Eschscholtz, 1823) by using oxidative stress enzymes, ATPases and cholinesterase as biomarkers	12
Shaddock (Citrus maxima) peels extract restores cognitive function, cholinergic and purinergic enzyme systems in scopolamine-induced amnesic rats	12
Morphine attenuates neurotoxic effects of MPTP in zebrafish embryos by regulating oxidant/antioxidant balance and acetylcholinesterase activity	11
A comparison of cell death mechanisms of antioxidants, butylated hydroxyanisole and butylated hydroxytoluene	11
Acrylamide induces intrinsic apoptosis and inhibits protective autophagy via the ROS mediated mitochondrial dysfunction pathway in U87-MG cells	11
The protective effects of vitamins A, C, and E on zinc oxide nanoparticles (ZnO NPs)-induced liver oxidative stress in male Wistar rats	11
Glabridin attenuates paracetamol-induced liver injury in mice via CYP2E1-mediated inhibition of oxidative stress	11
Mechanism of phthalate esters in the progression and development of breast cancer	10
The effect of sulfamethoxazole on oxidative stress indices in zebrafish (Danio rerio)	10
Acute and subchronic toxicity studies of rhein in immature and d-galactose-induced aged mice and its potential hepatotoxicity mechanisms	10
Neurotoxicity of poly(propylene imine) glycodendrimers	10
Role of aluminum exposure on Alzheimer’s disease and related glycogen synthase kinase pathway	10
Effects of ellagic acid in the testes of streptozotocin induced diabetic rats	10
L-Carnitine alleviates hepatic and renal mitochondrial-dependent apoptotic progression induced by letrozole in female rats through modulation of Nrf-2, Cyt c and CASP-3 signaling	10
Effect of carnosic acid on acrylamide induced neurotoxicity: in vivo and in vitro experiments	10
Risk assessment of elevated blood lead concentrations in the adult population using a decision tree approach	10
The genotoxic effects of mixture of aluminum, arsenic, cadmium, cobalt, and chromium on the gill tissue of adult zebrafish (Danio rerio, Hamilton 1822)	9
Health risk assessment of 42 pesticide residues in Tieguanyin tea from Fujian, China	9
Antiandrogen enzalutamide induced genetic, cellular, and hepatic damages: amelioration by triterpene Lupeol	9
Salvianolic acid A suppresses CCl₄-induced liver fibrosis through regulating the Nrf2/HO-1, NF-κB/IκBα, p38 MAPK, and JAK1/STAT3 signaling pathways	9
Effects of burnt tire-ash on Na⁺/K⁺, Ca²⁺-ATPase, serum immunoglobulin and brain acetylcholinesterase activities in clarias gariepinus (Burchell, 1822)	9
The role of ginger’s extract and N-acetylcysteine against docetaxel-induced oxidative stress and genetic disorder	9
Alogliptin attenuates cyclophosphamide-induced nephrotoxicity: a novel therapeutic approach through modulating MAP3K/JNK/SMAD3 signaling cascade	9
The impact of filtered water-pipe smoke on healthy versus cancer cells and their neurodegenerative role on AMPA receptor	9
Immunotoxic effects of force-fed ethephon on model organism Galleria mellonella (Lepidoptera: Pyralidae)	8
Sub-chronic and chronic toxicity evaluation of 7-methylxanthine: a new molecule for the treatment of myopia	8
The protective effect of herniarin on genotoxicity and apoptosis induced by cisplatin in bone marrow cells of rats	8
Cytogenetic effects of antidiabetic drug metformin	8
Protective effects of p-coumaric acid against gentamicin-induced nephrotoxicity in rats	8
Neuromodulatory and oxidative stress evaluations in African catfish Clarias gariepinus exposed to antipsychotic drug chlorpromazine	8
Protective effects of extracts of lichen Dirinaria consimilis (Stirton) D.D. Awasthi in bifenthrin- and diazinon-induced oxidative stress in rat erythrocytes in vitro	8
Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity in mice	8
Safety and biological activity evaluation of Uncaria rhynchophylla ethanolic extract	8
Therapeutic effects of thymoquinone or capsaicin on acrylamide-induced reproductive toxicity in rats mediated by their effect on oxidative stress, inflammation, and tight junction integrity	8
Evaluation of the toxicological effects of favipiravir (T-705) on liver and kidney in rats: biochemical and histopathological approach	8
Diosgenin inhibits TGF-β1/Smad signaling and regulates epithelial mesenchymal transition in experimental pulmonary fibrosis	8
Effects of acrylamide on protein degradation pathways in human liver-derived cells and the efficacy of N-acetylcysteine and curcumin	8
Co-drug of isoniazid and sulfur containing antioxidant for attenuation of hepatotoxicity and treatment of tuberculosis	8
Ameliorative effects of hexane extract of Garcinia kola seeds Heckel (Clusiaceae) in cisplatin-induced hepatorenal toxicity in mice	7
Exacerbation of diclofenac-induced gastroenterohepatic damage by concomitant exposure to sodium fluoride in rats: protective role of luteolin	7
Acute organophosphate and carbamate pesticide poisonings – a five-year survey from the National Poison Control Center Of Serbia	7
Neurotoxic responses of rainbow trout (Oncorhynchus mykiss) exposed to fipronil: multi-biomarker approach to illuminate the mechanism in brain	7
l-Theanine ameliorates motor deficit, mitochondrial dysfunction, and neurodegeneration against chronic tramadol induced rats model of Parkinson’s disease	7
Morel mushroom, Morchella from Kashmir Himalaya: a potential source of therapeutically useful bioactives that possess free radical scavenging, anti-inflammatory, and arthritic edema-inhibiting	7

Quercetin alleviates styrene oxide-induced cytotoxicity in cortical neurons in vitro via modulation of oxidative stress and apoptosis	7
Microplastic-induced oxidative stress response in turbot and potential intake by humans	7
Ochratoxin a in breast milk in Morocco: the affecting dietary habits of the lactating mothers and the degree of exposure of newborns “CONTAMILK study”	7
Evidence of drug-induced hepatotoxicity in the Maghrebian population	7
Investigation of the genotoxic effects of patent blue V (E131) in human peripheral lymphocytes and in silico molecular docking	7
Tucumã (Astrocaryum aculeatum) extract: phytochemical characterization, acute and subacute oral toxicity studies inWistarrats	7
Protective effects of resveratrol and avocado oil against paracetamol-induced hepatotoxicity in rats	7
Hepatoprotective effect of seabuckthorn leaf-extract in lead acetate-intoxicated Wistar rats	7
Centella asiatica prevents D-galactose-Induced cognitive deficits, oxidative stress and neurodegeneration in the adult rat brain	7
Enhanced fluorescent sensing probe via PbS quantum dots functionalized with gelatin for sensitive determination of toxic bentazon in water samples	7
Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP	7
Borassus flabellifer Linn haustorium methanol extract mitigates fluoride-induced apoptosis by enhancing Nrf2/Haeme oxygenase 1 –dependent glutathione metabolism in intestinal epithelial cells	7
Cocoyam (Colocasia esculenta) modulates some parameters of testosterone propionate-induced rat model of benign prostatic hyperplasia	7
PM_2.5from diesel exhaust attenuated fisetin mediated cytoprotection in H9c2 cardiomyocytes subjected to ischemia reoxygenation by inducing mitotoxicity	7
The effects of carvedilol, metoprolol and propranolol on cisplatin-induced kidney injury	7
Role of cinnamon oil against acetaminophen overdose induced neurological aberrations through brain stress and cytokine upregulation in rat brain	6
MicroRNA as an early diagnostic biomarker for contrast-induced acute kidney injury	6
Subacute oral toxicology and toxicokinetics of pterostilbene, a novel Top1/Tdp1 inhibiting anti-tumor reagent	6
In silico QSAR modeling to predict the safe use of antibiotics during pregnancy	6
Modulating effect of a hydroxychalcone and a novel coumarin–chalcone hybrid against mitomycin-induced genotoxicity in somatic cells of Drosophila melanogaster	6
Anticlastogenic, antimutagenic, and cytoprotective properties ofOrthosiphon stamineusethanolic leaves extract	6
Gallic acid ameliorates busulfan-induced testicular toxicity and damage in mature rats	6
Decision tree algorithm can determine the outcome of repeated supratherapeutic ingestion (RSTI) exposure to acetaminophen: review of 4500 national poison data system cases	6
The protective effect of rutin against busulfan-induced testicular damage in adult rats	6
Antioxidant, antinociceptive, anti-inflammatory, and hepatoprotective activities of pentacyclic triterpenes isolated from Ziziphus oxyphylla Edgew	6
Tempol (4-hydroxy tempo) protects mice from cisplatin-induced acute kidney injury via modulation of expression of aquaporins and kidney injury molecule-1	6
Psoralen induces liver injuries through endoplasmic reticulum stress signaling in female mice	6
Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats	6
Involvement of oxidative stress and toll-like receptor-4 signaling pathways in gentamicin-induced nephrotoxicity in male Sprague Dawley rats	6
Azithromycin effects on the European sea bass (Dicentrarchus labrax) early life stages following acute and chronic exposure: Laboratory bioassays	6
3,4-Dihydroxybenzaldehyde attenuates pentachlorophenol-induced cytotoxicity, DNA damage and collapse of mitochondrial membrane potential in isolated human blood cells	6
Nano-titanium nitride causes developmental toxicity in zebrafish through oxidative stress	6
Verbascoside inhibits paraquate-induced pulmonary toxicity via modulating oxidative stress, inflammation, apoptosis and DNA damage in A549 cell	5
Enniatin B induces dosage-related apoptosis or necrosis in mouse blastocysts leading to deleterious effects on embryo development	5
Ixazomib-associated cardiovascular adverse events in multiple myeloma: a systematic review and meta-analysis	5
Investigation of the effects of three different generations of fluoroquinolone derivatives on antioxidant and immunotoxic enzyme levels in different rat tissues	5
Trends of acute drug and chemical toxicities in adults and adolescents in Tehran, Iran between 2012 and 2018: a retrospective chart review	5
Nebivolol alleviates liver damage caused by methotrexate via AKT1/Hif1α/eNOS signaling	5
Protocatechuic acid protects against hepatorenal toxicities in rats exposed to Furan	5
Preventive treatment with sodium para-aminosalicylic acid inhibits manganese-induced apoptosis and inflammation via the MAPK pathway in rat thalamus	5
The effect of melatonin on testis histological changes and spermatogenesis indexes in mice following treatment with dexamethasone	5
Febuxostat, an inhibitor of xanthine oxidase, ameliorates ionizing radiation-induced lung injury by suppressing caspase-3, oxidative stress and NF-κB	5
Protective effect of Thymus munbyanus aqueous extract against 2,4-dichlorophenoxyacetic acid-induced nephrotoxicity in Wistar rats	5
Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate	5
Rutin ameliorates perfluorooctanoic acid-induced testicular injury in mice by reducing oxidative stress and improving lipid metabolism	5
Ameliorative role of inducible nitric oxide synthase inhibitors against sodium arsenite-induced renal and hepatic dysfunction in rats	5
Subacute toxicity study of the ethanolic extract of Mesua ferrea (L.) flowers in rats	5
Toxicological assessment of electronic cigarette vaping: an emerging threat to force health, readiness and resilience in the U.S. Army	5
Alpha-mangostin attenuates the apoptotic pathway of abamectin in the fetal rats’ brain by targeting pro-oxidant stimulus, catecholaminergic neurotransmitters, and transcriptional regulation of reelin	5
Exposure to pyrethroids induces behavioral impairments, neurofibrillary tangles and tau pathology in Alzheimer’s type neurodegeneration in adult Wistar rats	5
Toxicity of the herbicides used on herbicide-tolerant crops, and societal consequences of their use in France	5
Effects of prolonged subchronic benzo(α)pyrene exposure on rat liver morphology and CYP1A expression during treatment with menadione, quercetin, or tocopherol	5
Long-term toxicity of fluoroquinolones: a comprehensive review	5
Betaine attenuates sodium arsenite-induced renal dysfunction in rats	5