OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Analytical Toxicology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Screening of 104 New Psychoactive Substances (NPS) and Other Drugs of Abuse in Oral Fluid by LC–MS-MS	43
Blood Concentrations of Designer Benzodiazepines: Relation to Impairment and Findings in Forensic Cases	38
The Rise and Fall of Isotonitazene and Brorphine: Two Recent Stars in the Synthetic Opioid Firmament	32
A Comprehensive HPLC–MS-MS Screening Method for 77 New Psychoactive Substances, 24 Classic Drugs and 18 Related Metabolites in Blood, Urine and Oral Fluid	30
Recommendations for Toxicological Investigation of Drug-Impaired Driving and Motor Vehicle Fatalities—2021 Update	29
High Throughput Detection of 327 Drugs in Blood by LC–MS-MS with Automated Data Processing	29
A 2017–2019 Update on Acute Intoxications and Fatalities from Illicit Fentanyl and Analogs	29
Pharmacokinetics of Cannabis Brownies: A Controlled Examination of Δ9-Tetrahydrocannabinol and Metabolites in Blood and Oral Fluid of Healthy Adult Males and Females	29
First Report on Brorphine: The Next Opioid on the Deadly New Psychoactive Substance Horizon?	29
Xylazine: Pharmacology Review and Prevalence and Drug Combinations in Forensic Toxicology Casework	27
Postmortem Drug Redistribution: A Compilation of Postmortem/Antemortem Drug Concentration Ratios	27
Evaluation of Synthetic Cannabinoid Metabolites in Human Blood in the Absence of Parent Compounds: A Stability Assessment	26
Flualprazolam Blood Concentrations in 197 Forensic Investigation Cases	25
Toxic Metal-Containing Particles in Aerosols from Pod-Type Electronic Cigarettes	25
Determination of Third-Generation Synthetic Cannabinoids in Oral Fluids	22
Detection of 30 Fentanyl Analogs by Commercial Immunoassay Kits	22
Detection of Cannabinoids by LC–MS-MS and ELISA in Breast Milk	21
Eutylone Intoxications—An Emerging Synthetic Stimulant in Forensic Investigations	21
A Comprehensive Multi-Analyte Method for Hair Analysis: Substance-Specific Quantification Ranges and Tool for Task-Oriented Data Evaluation	21
Emergence of Delta-8 Tetrahydrocannabinol in DUID Investigation Casework: Method Development, Validation and Application	20
Development and Validation of an LC–MS-MS Method for the Detection of 40 Benzodiazepines and Three Z-Drugs in Blood and Urine by Solid-Phase Extraction	20
Variation in the Relative Isomer Abundance of Synthetic and Biologically Derived Phosphatidylethanols and Its Consequences for Reliable Quantification	20
Biomarkers of Recent Cannabis Use in Blood, Oral Fluid and Breath	19
Urinary Pharmacokinetic Profile of Cannabidiol (CBD), Δ9-Tetrahydrocannabinol (THC) and Their Metabolites following Oral and Vaporized CBD and Vaporized CBD-Dominant Cannabis Administration	19
Toxic Metals in Liquid and Aerosol from Pod-Type Electronic Cigarettes	18

Toxicological Analysis of Intoxications with Synthetic Cathinones	17
A UHPLC–MS-MS Method for the Determination of 84 Drugs of Abuse and Pharmaceuticals in Blood	17
Comprehensive Drug Screening of Whole Blood by LC–HRMS–MS in a Forensic Laboratory	16
Stability of Phosphatidylethanol 16:0/18:1 in Freshly Drawn, Authentic Samples from Healthy Volunteers	16
A Forward-Thinking Approach to Addressing the New Synthetic Opioid 2-Benzylbenzimidazole Nitazene Analogs by Liquid Chromatography–Tandem Quadrupole Mass Spectrometry (LC–QQQ-MS)	16
The Novel Psychoactive Substance Cumyl-CH-MEGACLONE: Human Phase-I Metabolism, Basic Pharmacological Characterization and Comparison to Other Synthetic Cannabinoid Receptor Agonists with a γ-Carboline	15
Quantification of Flualprazolam in Blood by LC–MS-MS: A Case Series of Nine Deaths	15
Determination of 30 Synthetic Cathinones in Postmortem Blood Using LC–MS-MS	15
An Enhanced LC–MS-MS Technique for Distinguishing Δ8- and Δ9-Tetrahydrocannabinol Isomers in Blood and Urine Specimens	15
Fentanyl and Driving Impairment	15
Time-Dependent Changes in THC Concentrations in Deceased Persons	15
Determination of Selected Cathinones in Blood by Solid-Phase Extraction and GC–MS	14
UPLC–MS-Based Procedures to Detect Prolyl-Hydroxylase Inhibitors of HIF in Urine	14
Comparison of Spectroscopic Techniques Combined with Chemometrics for Cocaine Powder Analysis	14
Quantitation of Δ8-THC, Δ9-THC, Cannabidiol and 10 Other Cannabinoids and Metabolites in Oral Fluid by HPLC–MS-MS	14
Determination and Distribution of Cannabinoids in Nail and Hair Samples	14
Reports of Adverse Events Associated with Use of Novel Psychoactive Substances, 2017–2020: A Review	14
Driving Impairment Cases Involving Etizolam and Flubromazolam	13
What Are the Prerequisites to Account for “No Fault” in Doping Control after an Adverse Analytical Finding Possibly due to Drug Contamination? Perspective from a Hair Testing Analyst	13
The Development and Validation of a Novel Designer Benzodiazepines Panel by LC–MS-MS	13
A Case Series of Etizolam in Opioid-Related Deaths	13
The Emergence of Deschloro-N-ethyl-ketamine, a Ketamine Analog, in Drug Seizures and Drug Driving Cases in Hong Kong	13
Pharmacokinetic Profile of ∆9-Tetrahydrocannabinol, Cannabidiol and Metabolites in Blood following Vaporization and Oral Ingestion of Cannabidiol Products	13
Novel and Nonroutine Benzodiazepines and Suvorexant by LC–MS-MS	12
Detection of l-Methamphetamine and l-Amphetamine as Selegiline Metabolites	12
Blood Phosphatidylethanol Concentrations Following Regular Exposure to an Alcohol-Based Mouthwash	12
Analytical Methodologies for the Characterization and Analysis of the Parent Compound and Phase I Metabolites of 4F-MDMB-BICA in Human Microsome, Urine and Blood Samples	12
Identification of Gamma-Butyrolactone in JUUL Liquids	12
Blood and Oral Fluid Cannabinoid Profiles of Frequent and Occasional Cannabis Smokers	12
Fully Automated Optical Hematocrit Measurement from Dried Blood Spots	12
Intoxications in an Australian Emergency Department Involving ‘Nitazene’ Benzylbenzimidazole Synthetic Opioids (Etodesnitazene, Butonitazene and Protonitazene)	12
Report on a New Opioid NPS: Chemical and In Vitro Functional Characterization of a Structural Isomer of the MT-45 Derivative Diphenpipenol	12
Simultaneous Quantification of 17 Cannabinoids by LC–MS-MS in Human Plasma	12
Development and Validation of a Method for Quantification of 28 Psychotropic Drugs in Postmortem Blood Samples by Modified Micro-QuEChERS and LC–MS-MS	12
Occurrence of Organochlorine Pesticides in Human Tissues Assessed Using a Microextraction Procedure and Gas Chromatography–Mass Spectrometry	11
Microextraction by Packed Sorbent as a Novel Strategy for Sample Clean-Up in the Determination of Methadone and EDDP in Hair	11
Flubromazolam-Derived Designer Benzodiazepines: Toxicokinetics and Analytical Toxicology of Clobromazolam and Bromazolam	11
Strategic Decision-Making by a Forensic Toxicology Laboratory in Response to an Emerging NPS: Detection, Quantitation and Interpretation of Carfentanil in Death Investigations in Ontario, Canada, July	11
Heroin-Related Compounds and Metabolic Ratios in Postmortem Samples Using LC–MS-MS	11
Safety, Pharmacokinetics and Pharmacodynamics of Spectrum Yellow Oil in Healthy Participants	11
∆8-THC, THC-O Acetates and CBD-di-O Acetate: Emerging Synthetic Cannabinoids Found in Commercially Sold Plant Material and Gummy Edibles	11
Phenethyl-4-ANPP: A Marginally Active Byproduct Suggesting a Switch in Illicit Fentanyl Synthesis Routes	11
The Difficult Interpretation of a Hair Test Result from a 32-Month-Old Child: Administration of Propranolol and Quetiapine or Contamination?	11
Growing Trends in the Efficient and Selective Extraction of Compounds in Complex Matrices Using Molecularly Imprinted Polymers and Their Relevance to Toxicological Analysis	11
A Single Method for 127 Recommended and Additional DUID Drugs in Blood and Urine by LC–MS-MS	11
Accidental Overdose Deaths in Oklahoma, 2002–2017: Opioid and Methamphetamine Trends	11
Quantification of 54 Benzodiazepines and Z-Drugs, Including 20 Designer Ones, in Plasma	10
Fatal N-Ethylhexedrone Intoxication	10
Time- and Site-Dependent Postmortem Redistribution of Antidepressants and Neuroleptics in Blood and Alternative Matrices	10
Determination of Seven Antidepressants in Pericardial Fluid by Means of Dispersive Liquid–Liquid Microextraction and Gas Chromatography–Mass Spectrometry	10

Prevalence of New Psychoactive Substances in Oral Fluid Samples from French Drivers: A Longitudinal Survey (2016–2020)	10
Buprenorphine-Related Deaths in North Carolina from 2010 to 2018	10
Free and Glucuronide Urine Cannabinoids after Controlled Smoked, Vaporized and Oral Cannabis Administration in Frequent and Occasional Cannabis Users	10
Determination of Ethyl Glucuronide and Ethyl Sulfate in Human Whole Blood and Vitreous Humor by LC–MS-MS and Applications to the Interpretation of Postmortem Ethanol Findings	10
Detection of Drugs in Postmortem Specimens of Blood, Vitreous Humor and Bone Marrow Aspirate	9
Death from Poppy Tea Consumption	9
The First Reported Case of a Synthetic Cannabinoid Ethyl Ester Detected in a Postmortem Blood Toxicological Analysis	9
Cannabinoids in Oral Fluid: Limiting Potential Sources of Cannabidiol Conversion to Δ9- and Δ8-Tetrahydrocannabinol	9
Two Single-Drug Fatal Intoxications by Mitragynine	9
LC–QTOF-MS Presumptive Identification of Synthetic Cannabinoids without Reference Chromatographic Retention/Mass Spectral Information. II. Evaluation of a Computational Approach for Predicting and Ide	9
Detection of ADB-BUTINACA Metabolites in Human Urine, Blood, Kidney and Liver	9
Metabolism Study of N-Methyl 2-Aminoindane (NM2AI) and Determination of Metabolites in Biological Samples by LC–HRMS	9
Inferences and Legal Considerations Following a Blood Collection Tube Recall	9
Veratrum Alkaloid Determination in Four Cases of Veratrum Aqua Poisonings	9
Identification and Quantification of Antipsychotics in Blood Samples by LC–MS-MS: Case Reports and Data from Three Years of Routine Analysis	9
Old Poison, New Problem: Cyanide Fatal Intoxications Associated with Internet Shopping	8
Cocaine External Contamination Can Be Documented by a Hair Test	8
Determination of Ketamine and Norketamine in Hair and Evaluation of Polydrug Use in Ketamine Abusers Using Hair Analysis in Korea	8
Fatal Rectal Injection of 3-MMC in a Sexual Context: Toxicological Investigations Including Metabolites Identification Using LC–HRMS	8
Determination of Cross-Reactivity of Contemporary Cannabinoids with THC Direct Immunoassay (ELISA) in Whole Blood	8
Analysis of the Illicit Opioid U-48800 and Related Compounds by LC–MS-MS and Case Series of Fatalities Involving U-48800	8
Diminished Consciousness in a Woman Following an Unsuspected Scopolamine Overdose	8
Screening of Synthetic Cathinones and Metabolites in Dried Blood Spots by UPLC–MS-MS	8
Toxicological Analysis of Cases of Mixed Poisonings with Synthetic Cathinones and Other Drugs of Abuse	8
Endogenous GHB in Segmented Hair Part I: Inter-individual Variation for Group Comparisons	8
The Future of Analytical and Interpretative Toxicology: Where are We Going and How Do We Get There?	8
Two Cyclopropyl Fentanyl Case Studies in Los Angeles	7
Increasing Prevalence of Ketamine in Drivers in New York City Including the Identification of 2-Fluoro-Deschloroketamine	7
Studies on the In Vitro and In Vivo Metabolic Fate of the New Psychoactive Substance N-Ethyl-N-Propyltryptamine for Analytical Purposes	7
A Case Study Evaluating the Efficacy of an Ad Hoc Hospital Collection Device for Fentanyl in Infant Oral Fluid	7
Sensitive Screening of New Psychoactive Substances in Serum Using Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry	7
LC–QTOF-MS Presumptive Identification of Synthetic Cannabinoids without Reference Chromatographic Retention/Mass Spectral Information. I. Reversed-Phase Retention Time QSPR Prediction as an Aid to Ide	7
Influence of Pain Killers on the Urinary Anabolic Steroid Profile	7
Can PEth be Detected with a Cutoff of 20 ng/mL after Single Alcohol Consumption?	7
Conversion of 7-Carboxy-Cannabidiol (7-COOH-CBD) to 11-Nor-9-Carboxy-Tetrahydrocannabinol (THC-COOH) during Sample Preparation for GC–MS Analysis	7
Incorporation of Methoxyphenamine into Hair in Early Stage after Intake	7
Green Analytical Toxicology for the Determination of Cocaine Metabolites	7
Simultaneous Determination of 5- and 6-APB in Blood, Other Body Fluids, Hair and Various Tissues by HPLC--MS-MS	7
Toxicological Analysis of Fluorofentanyl Isomers in Postmortem Blood	7
Melatonin Supplementation in Undetermined Pediatric Deaths	7
Postmortem Brain–Blood Ratios of Codeine, Fentanyl, Oxycodone and Tramadol	7
Determination of Fentanyl, Alpha-Methylfentanyl, Beta-Hydroxyfentanyl and the Metabolite Norfentanyl in Rat Urine by LC–MS-MS	7
In a Case of Death Involving Steroids, Hair Testing is More Informative than Blood or Urine Testing	7
Pharmacokinetics of Mephedrone and Its Metabolites in Whole Blood and Plasma after Controlled Intranasal Administration to Healthy Human Volunteers	7
Toxicological Investigation of a Case Series Involving the Synthetic Cathinone α-Pyrrolidinohexiophenone (α-PHP) and Identification of Phase I and II Metabolites in Human Urine	7
LC–MS-MS Analysis of Δ9-THC, CBN and CBD in Hair: Investigation of Artifacts	7
Can a Recently Developed Pig Model Be Used for In Vivo Metabolism Studies of 7-Azaindole-Derived Synthetic Cannabinoids? A Study Using 5F-MDMB-P7AICA	7
Application of Homogeneous Liquid–Liquid Microextraction With Switchable Hydrophilicity Solvents to the Determination of MDMA, MDA and NBOMes in Postmortem Blood Samples	7
Metabolic Profiles of 5F-MDMB-PICA in Human Urine, Serum and Hair Samples Using LC–Q Exactive HF-MS	7
Long-Term Stability of 13 Fentanyl Analogs in Blood	7
Detection of Drugs in Oral Fluid Samples Using a Commercially Available Collection Device: Agreement with Urine Testing and Evaluation of A and B Samples Obtained from Employees at Different Workplace	7
Characterizing the Transport of Aluminum-, Silicon- and Titanium-Containing Particles and Nanoparticles in Mainstream Tobacco Smoke	7
Quantification of Classic, Prescription and Synthetic Opioids in Hair by LC–MS-MS	7
Potential of High-Resolution Mass Spectrometry for the Detection of Drugs and Metabolites in Hair: Methoxetamine in a Real Forensic Case	7
A New Multi-Analyte LC–MS-MS Screening Method for the Detection of 120 NPSs and 49 Drugs in Hair	7
Fatal Intoxication by the Novel Cathinone 4-Fluoro-3-methyl-α-PVP	7