OOIR: Observatory of International Research

Papers

(The TQCC of Clinical Science is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Emerging role of carbonic anhydrase inhibitors	127
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer	125
The complex role of adipokines in obesity, inflammation, and autoimmunity	121
Pathogenesis of pneumonia and acute lung injury	109
Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways	100
The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease	100
Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway	91
M1/M2 macrophages and their overlaps – myth or reality?	80
Mechanisms of podocyte injury and implications for diabetic nephropathy	72
ACE2 and gut amino acid transport	70
Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities	63
Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP1	61
The immune niche of the liver	57
Cholesterol metabolism: a new molecular switch to control inflammation	53
Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression	52
Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway	52
ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV	50
Cardiotoxic effects of angiogenesis inhibitors	50
Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19	48
Inflammation: a putative link between phosphate metabolism and cardiovascular disease	45
ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19	44
The GCN5: its biological functions and therapeutic potentials	43
Klotho and calciprotein particles as therapeutic targets against accelerated ageing	40
Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice	40
Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis	40

Gut microbiome dysbiosis alleviates the progression of osteoarthritis in mice	40
Correcting the imbalanced protective RAS in COVID-19 with angiotensin AT2-receptor agonists	38
ACE2: from protection of liver disease to propagation of COVID-19	38
Epigenetic processes during preeclampsia and effects on fetal development and chronic health	38
ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease	37
Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis	37
ACE2 in the renin–angiotensin system	37
Host cell glutamine metabolism as a potential antiviral target	36
Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer’s disease	36
Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility	35
Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)	33
Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes	33
Obesity-associated cardiovascular risk in women: hypertension and heart failure	31
Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis	30
Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics	30
Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor	30
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability	29
Lipotoxicity: a driver of heart failure with preserved ejection fraction?	29
Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice	28
SIRT7 restricts HBV transcription and replication through catalyzing desuccinylation of histone H3 associated with cccDNA minichromosome	27
Aetiology of Type 2 diabetes in people with a ‘normal’ body mass index: testing the personal fat threshold hypothesis	27
Clinical perspectives on vagus nerve stimulation: present and future	27
Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease	26
Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid	26
Increased susceptibility to dextran sulfate-induced mucositis of iron-overload β-thalassemia mice, another endogenous cause of septicemia in thalassemia	26
Autophagy in asthma and chronic obstructive pulmonary disease	26
CYP1B1 as a therapeutic target in cardio-oncology	25
Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis	25
NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia	25
Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis	24
How accurate are citations of frequently cited papers in biomedical literature?	24
Molecular mechanisms of anthracycline cardiovascular toxicity	24
LncRNA HOTAIR modulates hepatitis B virus transcription and replication by enhancing SP1 transcription factor	24
The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases	24
Updates in deep learning research in ophthalmology	23
Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease	23
Smoking-induced microbial dysbiosis in health and disease	22
Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure	22
The PAR-1 antagonist vorapaxar ameliorates kidney injury and tubulointerstitial fibrosis	22
No evidence for brain renin–angiotensin system activation during DOCA-salt hypertension	22
Focal adhesion signaling: vascular smooth muscle cell contractility beyond calcium mechanisms	21
Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress	21
Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids	21
New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	21
SGLT2 inhibition versus sulfonylurea treatment effects on electrolyte and acid–base balance: secondary analysis of a clinical trial reaching glycemic equipoise: Tubular effects of SGLT2 inhibition in	20
Skeletal muscle redox signaling in rheumatoid arthritis	20
ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer	19
Eicosanoid receptors as therapeutic targets for asthma	19
Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction	19
Early elimination of uremic toxin ameliorates AKI-to-CKD transition	19

Interrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression	18
KLHDC7B-DT aggravates pancreatic ductal adenocarcinoma development via inducing cross-talk between cancer cells and macrophages	18
Key role for EphB2 receptor in kidney fibrosis	18
Cell-specific epigenetic changes in atherosclerosis	18
Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure	18
How dendritic cells sense and respond to viral infections	17
Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway	17
Gastrin, via activation of PPARα, protects the kidney against hypertensive injury	17
P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model	17
Vascular contributions to cognitive impairment and dementia: the emerging role of 20-HETE	17
Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms	17
Oxytocin signalling in dendritic cells regulates immune tolerance in the intestine and alleviates DSS-induced colitis	17
Microbiota transplants from feces or gut content attenuated portal hypertension and portosystemic collaterals in cirrhotic rats	17
The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling	16
Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension	16
The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension	16
Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor	16
IGF2 deficiency causes mitochondrial defects in skeletal muscle	16
Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases	16
Angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functions	16
Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors	15
CircUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis	15
Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men	15
ACE2, the kidney and the emergence of COVID-19 two decades after ACE2 discovery	15
The emerging role of LRRK2 in tauopathies	15
Non-invasive prenatal diagnosis (NIPD): how analysis of cell-free DNA in maternal plasma has changed prenatal diagnosis for monogenic disorders	14
Phosphate and fibroblast growth factor 23 in diabetes	14
ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders	14
Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents	14
Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice	13
Th2 cytokines-DUOX2-ROS-HMGB1 translocation axis is important in the pathogenesis of allergic rhinitis	13
The pleiotropic effects of antithrombotic drugs in the metabolic–cardiovascular–neurodegenerative disease continuum: impact beyond reduced clotting	13
A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice	13
Unravelling the tangled web of hypertension and cancer	13
The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease	13
Vinpocetine protects against the development of experimental abdominal aortic aneurysms	13
Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease	13
Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome	13
By what molecular mechanisms do social determinants impact cardiometabolic risk?	13
Protective role of kallistatin in renal fibrosis via modulation of Wnt/β-catenin signaling	13
Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity	13
Preeclampsia and syncytiotrophoblast membrane extracellular vesicles (STB-EVs)	13
Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?	13
Multicellular regulation of miR-196a-5p and miR-425-5 from adipose stem cell-derived exosomes and cardiac repair	13
Methylglyoxal and glyoxalase 1—a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes	12
Recent advances in understanding ion transport mechanisms in polycystic kidney disease	12
Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy	12
ACE2 activator diminazene aceturate exerts renoprotective effects in gentamicin-induced acute renal injury in rats	12
Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection	12
Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO/sGC/cGMP pathway	12
Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection	12
Maternal microvascular dysfunction during preeclamptic pregnancy	12
Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads	12
In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system	12
Acid sphingomyelinase promotes SGK1-dependent vascular calcification	12
Novel mediators of idiopathic pulmonary fibrosis	12