OOIR: Observatory of International Research

Papers

(The TQCC of Clinical Science is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Emerging role of carbonic anhydrase inhibitors	109
Placental function in maternal obesity	103
The complex role of adipokines in obesity, inflammation, and autoimmunity	92
The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease	91
miR-210 transferred by lung cancer cell-derived exosomes may act as proangiogenic factor in cancer-associated fibroblasts by modulating JAK2/STAT3 pathway	88
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer	85
Covid-19: the renin–angiotensin system imbalance hypothesis	78
Bidirectional interaction of airway epithelial remodeling and inflammation in asthma	73
Decoy ACE2-expressing extracellular vesicles that competitively bind SARS-CoV-2 as a possible COVID-19 therapy	73
Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases	72
Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission	67
ACE2 and gut amino acid transport	65
The molecular mechanism of mechanotransduction in vascular homeostasis and disease	59
Emerging roles for the IL-6 family of cytokines in pancreatic cancer	59
Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways	59
Microvascular disease in chronic kidney disease: the base of the iceberg in cardiovascular comorbidity	58
Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway	58
Pathogenesis of pneumonia and acute lung injury	56
Gut dysbiosis is associated with primary hypothyroidism with interaction on gut-thyroid axis	52
Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities	51
Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP1	51
ACE2 the Janus-faced protein – from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19	49
ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV	45
Cardiotoxic effects of angiogenesis inhibitors	45
Targeting perivascular and epicardial adipose tissue inflammation: therapeutic opportunities for cardiovascular disease	44

Cholesterol metabolism: a new molecular switch to control inflammation	43
Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression	42
Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19	41
Mechanisms of podocyte injury and implications for diabetic nephropathy	41
Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function	41
Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway	40
Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice	40
Flavonoids in adipose tissue inflammation and atherosclerosis: one arrow, two targets	39
Inflammation: a putative link between phosphate metabolism and cardiovascular disease	39
The immune niche of the liver	39
Myeloid-derived suppressor cells shift Th17/Treg ratio and promote systemic lupus erythematosus progression through arginase-1/miR-322-5p/TGF-β pathway	38
The GCN5: its biological functions and therapeutic potentials	37
ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19	37
Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice	37
Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease	36
SARS-CoV2 may evade innate immune response, causing uncontrolled neutrophil extracellular traps formation and multi-organ failure	36
Eicosanoid blood vessel regulation in physiological and pathological states	35
Correcting the imbalanced protective RAS in COVID-19 with angiotensin AT2-receptor agonists	35
ACE2: from protection of liver disease to propagation of COVID-19	35
Gut microbiome dysbiosis alleviates the progression of osteoarthritis in mice	34
Maternal high-fat diet induces long-term obesity with sex-dependent metabolic programming of adipocyte differentiation, hypertrophy and dysfunction in the offspring	34
Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis	32
Klotho and calciprotein particles as therapeutic targets against accelerated ageing	32
Vascular toxicity associated with anti-angiogenic drugs	32
Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer’s disease	31
Host cell glutamine metabolism as a potential antiviral target	31
ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease	31
Targeting mitochondrial fitness as a strategy for healthy vascular aging	30
Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis	30
miR-20a-5p is enriched in hypoxia-derived tubular exosomes and protects against acute tubular injury	30
ACE2 in the renin–angiotensin system	28
Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies	28
From animal models to patients: the role of placental microRNAs, miR-210, miR-126, and miR-148a/152 in preeclampsia	28
An inducible intestinal epithelial cell-specific NHE3 knockout mouse model mimicking congenital sodium diarrhea	28
Long noncoding RNA Hotair facilitates retinal endothelial cell dysfunction in diabetic retinopathy	28
Increased susceptibility to dextran sulfate-induced mucositis of iron-overload β-thalassemia mice, another endogenous cause of septicemia in thalassemia	26
Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility	26
Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications	26
Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS	26
Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes	26
Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner	26
Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis	26
Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)	25
Epigenetic processes during preeclampsia and effects on fetal development and chronic health	25
Back to the future: re-establishing guinea pigin vivoasthma models	25
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability	25
Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics	25
Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction	25
M1/M2 macrophages and their overlaps – myth or reality?	25
Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor	25

Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies	24
Non-alcoholic fatty liver disease: a metabolic burden promoting atherosclerosis	24
Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid	24
Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice	22
Lipotoxicity: a driver of heart failure with preserved ejection fraction?	22
LncRNA HOTAIR modulates hepatitis B virus transcription and replication by enhancing SP1 transcription factor	22
Alternative splicing of ACE2 possibly generates variants that may limit the entry of SARS-CoV-2: a potential therapeutic approach using SSOs	22
Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease	22
Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway	21
CYP1B1 as a therapeutic target in cardio-oncology	21
Sex diversity in proximal tubule and endothelial gene expression in mice with ischemic acute kidney injury	21
How accurate are citations of frequently cited papers in biomedical literature?	21
Pathogenic role of human C-reactive protein in diabetic retinopathy	21
Obesity-associated cardiovascular risk in women: hypertension and heart failure	20
Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/β-catenin signalling pathway	20
Autophagy in asthma and chronic obstructive pulmonary disease	20
SIRT7 restricts HBV transcription and replication through catalyzing desuccinylation of histone H3 associated with cccDNA minichromosome	20
No evidence for brain renin–angiotensin system activation during DOCA-salt hypertension	20
The PAR-1 antagonist vorapaxar ameliorates kidney injury and tubulointerstitial fibrosis	20
Metformin alleviates hyperuricaemia-induced serum FFA elevation and insulin resistance by inhibiting adipocyte hypertrophy and reversing suppressed white adipose tissue beiging	20
Effects of corticosteroids on COPD lung macrophage phenotype and function	20
NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia	19
Molecular mechanisms of anthracycline cardiovascular toxicity	19
SGLT2 inhibition versus sulfonylurea treatment effects on electrolyte and acid–base balance: secondary analysis of a clinical trial reaching glycemic equipoise: Tubular effects of SGLT2 inhibition in	19
Updates in deep learning research in ophthalmology	19
Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease	19
Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure	19
Tumoral PD-1hiCD8+ T cells are partially exhausted and predict favorable outcome in triple-negative breast cancer	19
Cirrhosis and insulin resistance: current knowledge, pathophysiological mechanisms, complications and potential treatments	19
Skeletal muscle redox signaling in rheumatoid arthritis	18
Clinical perspectives on vagus nerve stimulation: present and future	18
Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis	18
The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases	18
RNA-binding protein CELF1 enhances cell migration, invasion, and chemoresistance by targeting ETS2 in colorectal cancer	18
Forsythoside A protects against lipopolysaccharide-induced acute lung injury through up-regulating microRNA-124	18
P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model	17
Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids	17
Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure	17
How dendritic cells sense and respond to viral infections	16
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells	16
Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor	16
Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction	16
Eicosanoid receptors as therapeutic targets for asthma	16
HMGB1 A box protects neurons by potently inhibiting both microglia and T cell-mediated inflammation in a mouse Parkinson’s disease model	16
Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases	16
KLHDC7B-DT aggravates pancreatic ductal adenocarcinoma development via inducing cross-talk between cancer cells and macrophages	16
Discovery and characterization of ACE2 – a 20-year journey of surprises from vasopeptidase to COVID-19	16
p110δ PI3K as a therapeutic target of solid tumours	15
Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors	15
The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling	15
Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway	15
IL-33 induces type-2-cytokine phenotype but exacerbates cardiac remodeling post-myocardial infarction with eosinophil recruitment, worsened systolic dysfunction, and ventricular wall rupture	15
Renal functional effects of the highly selective AT2R agonist, β-Pro7 Ang III, in normotensive rats	15
Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function	15
Focal adhesion signaling: vascular smooth muscle cell contractility beyond calcium mechanisms	15
Oxytocin signalling in dendritic cells regulates immune tolerance in the intestine and alleviates DSS-induced colitis	15
Interrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression	14
Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms	14
Brain angiotensin converting enzyme-2 in central cardiovascular regulation	14
DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway	14
Enhanced SMARCD1, a subunit of the SWI/SNF complex, promotes liver cancer growth through the mTOR pathway	14
Potential role of diacylglycerol kinases in immune-mediated diseases	14
Modulation of microglial phenotypes improves sepsis-induced hippocampus-dependent cognitive impairments and decreases brain inflammation in an animal model of sepsis	14
CircUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis	14
Using nuclear envelope mutations to explore age-related skeletal muscle weakness	14
Early elimination of uremic toxin ameliorates AKI-to-CKD transition	14
Genetic deficiency of Phactr1 promotes atherosclerosis development via facilitating M1 macrophage polarization and foam cell formation	14
Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis	14
Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress	14
ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer	14
ACE2, the kidney and the emergence of COVID-19 two decades after ACE2 discovery	14
Microbiota transplants from feces or gut content attenuated portal hypertension and portosystemic collaterals in cirrhotic rats	14