OOIR: Observatory of International Research

Papers

(The TQCC of Clinical Science is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
α-Adrenergic blockade prevented environmental temperature reduction-induced transient portal pressure surge in cirrhotic and portal hypertensive rats	302
Expression of Concern: Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression	226
The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models	224
Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation	198
Maintaining energy provision in the heart: the creatine kinase system in ischaemia–reperfusion injury and chronic heart failure	168
Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?	137
Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of CaV1.2 calcium channel in hypertension	111
Metal regulation of Mycobacterium tuberculosis SufB intein splicing at the host–pathogen crossroad	85
Measuring muscle protein synthesis in humans and the influence of nutritional state	72
Effect of metformin in a novel experimental model of peripheral artery disease	60
Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities	55
Cardiovascular research at the Heart of Clinical Science	49
Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury	47
Osteoprotegerin regulates vascular function through syndecan-1 and NADPH oxidase-derived reactive oxygen species	46
Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease	45
CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial–mesenchymal transition via inhibiting MDM2	45
Antiviral activities of hemp cannabinoids	44
Tetramethylpyrazine attenuates renal tubular epithelial cell ferroptosis in contrast-induced nephropathy by inhibiting transferrin receptor and intracellular reactive oxygen species	44
Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis	44
Correction: Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C	43
Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice	38
Oxytocin: much more than childbirth and milk letdown	38
Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep	38
Maternal high-fat diet regulates offspring hepatic ABCG5 expression and cholesterol metabolism via the gut microbiota and its derived butyrate	33
Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction	30

Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients	30
Correction: Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma	30
NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose	29
Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection	29
Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein	28
IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53	28
Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies	28
Circulating cell-free micro-RNA as biomarkers: from myocardial infarction to hypertension	26
Serum proteomics links the cardiorespiratory biomarkers CTRC, OSM, and MMP-10 to exacerbation severity and number in patients with COPD	26
Utility of preclinical models of altered maternal nutrition to support the developmental origins of health and disease hypothesis	26
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of increasing M2 macrophages	25
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of lowering blood pressure	25
Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis	25
The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy	22
New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	22
Adverse effects of ovarian cryopreservation and auto-transplantation on ovarian grafts and quality of produced oocytes in a mouse model	22
Set7 methyltransferase roles in myocardial protection from chronic stressors	22
Correction: The vascular Na,K-ATPase: clinical implications in stroke, migraine, and hypertension	21
By what molecular mechanisms do social determinants impact cardiometabolic risk?	21
Expression of Concern: Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice	21
Piezo channels in JG cells do not regulate renin expression or renin release to the circulation	21
Paternal long-term PM2.5 exposure causes hypertension via increased renal AT1R expression and function in male offspring	20
Enhanced STAT3/PIK3R1/mTOR signaling triggers tubular cell inflammation and apoptosis in septic-induced acute kidney injury: implications for therapeutic intervention	20
Endothelin and the tumor microenvironment: a finger in every pie	19
Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms	19
Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways	19
Molecular and cellular regulation of psoriatic inflammation	18
High sodium promotes the secretion and synthesis of PTH through PiT-1-IKKβ pathway in parathyroid gland in vitro	18
Inflammatory liver diseases and susceptibility to sepsis	18
Human placental lipid content and lipid metabolic enzyme abundance in obesity and across gestation	18
Correction: Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research	18
The emerging role of LRRK2 in tauopathies	18
MicroRNAs as messengers of liver diseases: has the message finally been decrypted?	18
Cellular senescence and kidney aging	18
SARS-CoV-2 spike protein causes cardiovascular disease independent of viral infection	18
Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction	17
The O-GlcNAc dichotomy: when does adaptation become pathological?	17
Vascular dysfunction in COVID-19 patients: update on SARS-CoV-2 infection of endothelial cells and the role of long non-coding RNAs	17
Alveolar epithelial cells of lung fibrosis patients are susceptible to severe virus-induced injury	17
Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery	17
Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-γ axis	17
Protective effect of mesenchymal stromal cells in diabetic nephropathy: the In vitro and In vivo role of the M-Sec-tunneling nanotubes	16
Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis	16
Participation of the spleen in the neuroinflammation after pilocarpine-induced status epilepticus: implications for epileptogenesis and epilepsy	16
NaHCO3 loading causes increased arterial pressure and kidney damage in rats with chronic kidney disease	16
Molecular regulators of defective placental and cardiovascular development in fetal growth restriction	16
Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection	16
Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge	16
G-protein-coupled receptor MAS deletion produces a preeclampsia-like phenotype in FVB/N mice	16
The novel AT2 receptor ligand, β-Pro7 Ang III, induces equivalent anti-fibrotic effects to Compound 21 but broader anti-fibrotic effects than pirfenidone in mice with bleomycin-induced pulmonary fibro	16

SDMA as a marker and mediator in cerebrovascular disease	16
Brief early life angiotensin-converting enzyme inhibition attenuates the diuretic response to saline loading in sheep with solitary functioning kidney	16
Retraction: Overexpression of TrpC5 promotes tumor metastasis via the HIF-1α/Twist signaling pathway in colon cancer	15
The complex genetic basis of fibromuscular dysplasia, a systemic arteriopathy associated with multiple forms of cardiovascular disease	15
ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE−/− mice	15
Endothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions	15
Urine-derived renal epithelial cells for deep phenotyping and transcriptomic response to therapy in Fabry disease	15
Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease	15
Umbilical cord mesenchymal stem cells from gestational diabetes show impaired ability to up-regulate paracellular permeability from sub-endothelial niche	15
Serpina3c deficiency promotes obesity-related hypertriglyceridemia and inflammation through activation of the Hif1α-glycolysis axis in adipose tissue	15
Regulation of Na+-K+-ATPase leads to disturbances of isoproterenol-induced cardiac dysfunction via interference of Ca2+-dependent cardiac metabolism	14
Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis	14
SMAD5 as a novel gene for familial pulmonary arterial hypertension	14
The role of microRNAs in pregnancies complicated by maternal diabetes	14
Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy	14
A new mechanism of arterial calcification in diabetes: interaction between H3K18 lactylation and CHI3L1	14
Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases	13
Microbiota transplants from feces or gut content attenuated portal hypertension and portosystemic collaterals in cirrhotic rats	13
Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity	13
Expression of Concern: Mitochondrial dynamic modulation exerts cardiometabolic protection in obese insulin-resistant rats	13
Novel mediators of idiopathic pulmonary fibrosis	13
PE (0:0/14:0), an endogenous metabolite of the gut microbiota, exerts protective effects against sepsis-induced intestinal injury by modulating the AHR/CYP1A1 pathway	13
The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies	13
Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity	13
Correction: Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway -Application to a biomarker for atherosclerosis	12
Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease	12
Differences in endothelial function between patients with Type 1 and Type 2 diabetes: effects of red blood cells and arginase	12
Correction: New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	12
Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer	12
CGRP alleviates lipopolysaccharide-induced ARDS inflammation via the HIF-1α signaling pathway	12
RNA-binding protein HuR regulates the transition of septic AKI to CKD by modulating CD147	12
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis	12
Elevated phenylacetylglutamine caused by gut dysbiosis associated with type 2 diabetes increases neutrophil extracellular traps formation and exacerbates brain infarction	12
When the liver is in poor condition, so is the heart – cardiac remodelling in MASH mouse models	11
Cancer and sepsis	11
Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease	11
Epigenomic alterations in cancer: mechanisms and therapeutic potential	11
Skeletal muscle dysfunction with advancing age	11
Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice	11
Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype	11
Mechanistic insights into the development of severe fetal growth restriction	11
Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation	11
Hypertension: a lymphatic disease?	11
Emergent players in renovascular disease	11