OOIR: Observatory of International Research

Papers

(The TQCC of Clinical Science is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Transferrin promotes chondrogenic differentiation in condylar growth through inducing autophagy via ULK1-ATG16L1 axis	137
Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype	127
The science of science: Clinical Science launches a new translational meta-research collection	123
Inhibition of monoamine oxidase B reduces atherosclerosis and fatty liver in mice	121
Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK	113
Visualization of regenerating and repairing hearts	109
Autoimmune-mediated renal disease and hypertension	100
Cancer therapy-related cardiac dysfunction: is endothelial dysfunction at the heart of the matter?	98
Targeted bisulfite resequencing of differentially methylated cytosines in pre-eclampsia reveals a skewed dynamic balance in the DNA methylation of enhancers	76
Edema and lymphatic clearance: molecular mechanisms and ongoing challenges	57
Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats	53
Gstp1 negatively regulates blood pressure in hypertensive rat via promoting APLNR ubiquitination degradation mediated by Nedd4	52
Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases	48
The tendency of anemia of inflammation in periodontal diseases	40
Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity	40
Vincristine attenuates cardiac fibrosis through the inhibition of NLRP3 inflammasome activation	40
Importance of the gut microbiota in mice with a ‘humanized’ bile acid pool	38
Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT1a receptors in the proximal tubule of the kidney	37
Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of CaV1.2 calcium channel in hypertension	35
Is endothelin targeting finally ready for prime time?	35
Mechanistic science in cardiovascular-oncology: the way forward to maximise anti-cancer drug effects and minimise cardiovascular toxicity	33
Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?	33
Protecting glomerulus: role of angiotensin-II type 2 receptor	33
Regulation of Na+-K+-ATPase leads to disturbances of isoproterenol-induced cardiac dysfunction via interference of Ca2+-dependent cardiac metabolism	31
Th2 cytokines-DUOX2-ROS-HMGB1 translocation axis is important in the pathogenesis of allergic rhinitis	31

Metal regulation of Mycobacterium tuberculosis SufB intein splicing at the host–pathogen crossroad	31
C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT2, Mas and B2 receptors	30
α-Adrenergic blockade prevented environmental temperature reduction-induced transient portal pressure surge in cirrhotic and portal hypertensive rats	30
Novel avenues to control blood pressure: targeting the renal lymphatic system	30
Novel mediators of idiopathic pulmonary fibrosis	29
Maternal intermittent fasting during pregnancy: a translational research challenge for an important clinical scenario	29
PE (0:0/14:0), an endogenous metabolite of the gut microbiota, exerts protective effects against sepsis-induced intestinal injury by modulating the AHR/CYP1A1 pathway	29
Cardiovascular toxicity of angiogenesis inhibitors and immune checkpoint inhibitors: synergistic anti-tumour effects at the cost of increased cardiovascular risk?	27
Interactions between cardiology and oncology drugs in precision cardio-oncology	27
Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy.	27
Genetically inducing renal lymphangiogenesis attenuates hypertension in mice	26
Measuring muscle protein synthesis in humans and the influence of nutritional state	26
Maintaining energy provision in the heart: the creatine kinase system in ischaemia–reperfusion injury and chronic heart failure	25
Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity	24
Microbiota transplants from feces or gut content attenuated portal hypertension and portosystemic collaterals in cirrhotic rats	24
CXCL5 inhibition ameliorates acute kidney injury and prevents the progression from acute kidney injury to chronic kidney disease	23
Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes	23
Physiological response to fetal intravenous lipid emulsion	22
miR-486-5p protects against rat ischemic kidney injury and prevents the transition to chronic kidney disease and vascular dysfunction	22
Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up	21
The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease	21
Cell-specific epigenetic changes in atherosclerosis	19
Youth versus adult-onset type 2 diabetic kidney disease: Insights into currently known structural differences and the potential underlying mechanisms	19
The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models	19
Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver	18
Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation	18
SIRT7 restricts HBV transcription and replication through catalyzing desuccinylation of histone H3 associated with cccDNA minichromosome	18
The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies	18
PDCD10 promotes the tumor-supporting functions of TGF-β in pancreatic cancer	18
Flavonoid derivative DMXAA attenuates cisplatin-induced acute kidney injury independent of STING signaling	18
Emerging role of carbonic anhydrase inhibitors	17
Clinical perspectives on vagus nerve stimulation: present and future	17
G-protein-coupled receptor kinase 4 causes renal angiotensin II type 2 receptor dysfunction by increasing its phosphorylation	17
Early elimination of uremic toxin ameliorates AKI-to-CKD transition	17
The double sides of NLRP3 inflammasome activation in sepsis	17
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer	17
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability	17
New discoveries in bile acids, gut microbiota and host interactions in health and diseases	16
Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities	16
Expression of Concern: Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression	16
Retraction: Relaxin improves multiple markers of wound healing and ameliorates the disturbed healing pattern of genetically diabetic mice	16
Perinatal iron restriction is associated with changes in neonatal cardiac function and structure in a sex-dependent manner	16
Increased angiotensin II formation in the brain modulates cardiovascular homeostasis and erythropoiesis	16
Aging and sex differences in salt sensitivity of blood pressure	15
Retraction: BMSC-derived exosomes carrying microRNA-122-5p promote progression of osteoblasts in osteonecrosis of the femoral head	15
SMAD5 as a novel gene for familial pulmonary arterial hypertension	15
Oxytocin: much more than childbirth and milk letdown	14
Murine endometrial-derived mesenchymal stem cells suppress experimental autoimmune encephalomyelitis depending on indoleamine-2,3-dioxygenase expression	14
Vascular contributions to cognitive impairment and dementia: the emerging role of 20-HETE	14
Protective role of serpina3c as a novel thrombin inhibitor against atherosclerosis in mice	14

Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia	14
Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction	13
Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D1R expression	13
Decoding the role of leptin and adiponectin in obesity-related gastrointestinal cancer	13
Microbiota transplantation in portal hypertension: promises and pitfalls	13
Circular RNAs and acute kidney injury: a Clinical Science commentary on Cao et al.	13
Cellular and molecular mechanisms of breast cancer susceptibility	13
Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition	13
Cardiovascular research at the Heart of Clinical Science	13
Endothelial progenitor cells in pregnancy-related diseases	13
Maternal high-fat diet regulates offspring hepatic ABCG5 expression and cholesterol metabolism via the gut microbiota and its derived butyrate	13
A comprehensive characterization of cell-free RNA in spent blastocyst medium and quality prediction for blastocyst	13
Cancer and sepsis	13
Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury	13
Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice	13
Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo	12
Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype	12
CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial–mesenchymal transition via inhibiting MDM2	12
Osteoprotegerin regulates vascular function through syndecan-1 and NADPH oxidase-derived reactive oxygen species	12
Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse model	12
Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice	12
Protective role of kallistatin in renal fibrosis via modulation of Wnt/β-catenin signaling	12
Small extracellular vesicles: a new player in GDM pathogenesis	12
The endothelin-1-driven tumor-stroma feed-forward loops in high-grade serous ovarian cancer	12
Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury	11
Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease	11
PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB	11
USP38 regulates inflammatory cardiac remodeling after myocardial infarction	11
Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway	11
Smoking-induced microbial dysbiosis in health and disease	11
Mechanistic insights into the development of severe fetal growth restriction	11
Antiviral activities of hemp cannabinoids	11
Blocking of interleukin-1 suppresses angiotensin II-induced renal injury	11
Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice	11
Platelets: the peripheral donor of mitochondria for diabetes-induced cognitive impairment	11
Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling	11
Maternal microvascular dysfunction during preeclamptic pregnancy	10
A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases	10
Skeletal muscle dysfunction with advancing age	10
Differences in endothelial function between patients with Type 1 and Type 2 diabetes: effects of red blood cells and arginase	10
Maternal hepatic adaptations during obese pregnancy encompass lobe-specific mitochondrial alterations and oxidative stress	10
Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis	10
Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease	10
How animal models can be utilized to find new biomarkers for cardiovascular diseases	10
Obesity-associated cardiovascular risk in women: hypertension and heart failure	10
REV-ERBα agonist SR10067 attenuates Th2 cytokine-mediated barrier dysfunction in human bronchial epithelial cells	10
Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents	10
Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor	10
TGFβ1, SMAD and β-catenin in pulmonary arteries of smokers, patients with small airway disease and COPD: potential drivers of EndMT	10
Tetramethylpyrazine attenuates renal tubular epithelial cell ferroptosis in contrast-induced nephropathy by inhibiting transferrin receptor and intracellular reactive oxygen species	10
Dysregulated haemostasis in thrombo-inflammatory disease	10
Sex differences in physiological response to increased neuronal excitability in a knockin mouse model of pediatric epilepsy	10