OOIR: Observatory of International Research

Papers

(The TQCC of Clinical Science is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Measuring muscle protein synthesis in humans and the influence of nutritional state	490
Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities	320
Metal regulation of Mycobacterium tuberculosis SufB intein splicing at the host–pathogen crossroad	319
α-Adrenergic blockade prevented environmental temperature reduction-induced transient portal pressure surge in cirrhotic and portal hypertensive rats	104
Effect of metformin in a novel experimental model of peripheral artery disease	83
The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models	79
Loss of LCAT function aggravates metabolic-associated steatohepatitis (MASH) in golden Syrian hamster	62
Chronic stress and the IL-10-mediated immunoregulatory loop in the pathogenesis of periodontitis	61
Expression of Concern: Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression	61
Maintaining energy provision in the heart: the creatine kinase system in ischaemia–reperfusion injury and chronic heart failure	59
Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation	58
Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of CaV1.2 calcium channel in hypertension	58
Inhibition of CCL4 prevents renal inflammation and fibrosis in acute kidney injury	54
Cardiovascular research at the Heart of Clinical Science	53
Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice	49
The multifactorial role of HDAC9 at the maternal–fetal interface in the pathogenesis of preeclampsia	46
Tetramethylpyrazine attenuates renal tubular epithelial cell ferroptosis in contrast-induced nephropathy by inhibiting transferrin receptor and intracellular reactive oxygen species	46
Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep	44
Antiviral activities of hemp cannabinoids	43
Correction: Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C	41
ASGR1 induces neutrophil extracellular traps formation to exacerbate sepsis-induced myocardial injury and cardiac dysfunction through SLC7A11 ubiquitination	40
Maternal high-fat diet regulates offspring hepatic ABCG5 expression and cholesterol metabolism via the gut microbiota and its derived butyrate	39
Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis	36
Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury	33
Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction	32

Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients	31
Set7 methyltransferase roles in myocardial protection from chronic stressors	29
CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial–mesenchymal transition via inhibiting MDM2	29
Adverse effects of ovarian cryopreservation and auto-transplantation on ovarian grafts and quality of produced oocytes in a mouse model	29
Utility of preclinical models of altered maternal nutrition to support the developmental origins of health and disease hypothesis	28
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of lowering blood pressure	27
NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose	26
IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53	26
Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis	26
Correction: Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma	26
Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies	26
Circulating cell-free micro-RNA as biomarkers: from myocardial infarction to hypertension	25
The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy	25
By what molecular mechanisms do social determinants impact cardiometabolic risk?	24
Retraction: Inhibition of mitochondrial fission as a novel therapeutic strategy to reduce mortality upon myocardial infarction	24
Chronic pyridostigmine is antiarrhythmic in Spontaneously hypertensive rats (SHR) but detrimental in normotensive WKY rats	24
Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection	24
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of increasing M2 macrophages	23
Serum proteomics links the cardiorespiratory biomarkers CTRC, OSM, and MMP-10 to exacerbation severity and number in patients with COPD	23
New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	23
Piezo channels in JG cells do not regulate renin expression or renin release to the circulation	22
Advances in understanding lipid metabolism in oligodendrocyte development and neurodegenerative diseases	22
Expression of Concern: Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice	22
Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways	21
Fentanyl exposure during preconception and gestation permanently dysregulates endogenous opioid peptides and sympathoadrenal-medullary axis in the offspring	21
Platelets from older adults exhibit differences in mitochondrial function associated with impaired glucose metabolism	21
Correction: The vascular Na,K-ATPase: clinical implications in stroke, migraine, and hypertension	21
Molecular and cellular regulation of psoriatic inflammation	21
ZNF827 pleiotropic cardiovascular risk locus involves regulation by Nuclear Factor-1 transcription factors	20
Human placental lipid content and lipid metabolic enzyme abundance in obesity and across gestation	20
Enhanced STAT3/PIK3R1/mTOR signaling triggers tubular cell inflammation and apoptosis in septic-induced acute kidney injury: implications for therapeutic intervention	19
Cellular senescence and kidney aging	18
Endothelin and the tumor microenvironment: a finger in every pie	18
Correction: Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research	18
High sodium promotes the secretion and synthesis of PTH through PiT-1-IKKβ pathway in parathyroid gland in vitro	17
The O-GlcNAc dichotomy: when does adaptation become pathological?	17
Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection	17
Participation of the spleen in the neuroinflammation after pilocarpine-induced status epilepticus: implications for epileptogenesis and epilepsy	17
Vascular dysfunction in COVID-19 patients: update on SARS-CoV-2 infection of endothelial cells and the role of long non-coding RNAs	17
Impact of the natural female reproductive aging on the rat serum lipidome	17
SDMA as a marker and mediator in cerebrovascular disease	16
Protective effect of mesenchymal stromal cells in diabetic nephropathy: the In vitro and In vivo role of the M-Sec-tunneling nanotubes	16
Placental ferroptosis and impaired fetal growth in symptomatic and asymptomatic SARS-CoV-2 infections	16
Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery	16
Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction	16
Endothelial TET2 deficiency exacerbates diabetic coronary microvascular dysfunction via CMPK2-mediated mitochondrial impairment	16
Molecular regulators of defective placental and cardiovascular development in fetal growth restriction	16
Inflammatory liver diseases and susceptibility to sepsis	16
The emerging role of LRRK2 in tauopathies	15
Alveolar epithelial cells of lung fibrosis patients are susceptible to severe virus-induced injury	15

The novel AT2 receptor ligand, β-Pro7 Ang III, induces equivalent anti-fibrotic effects to Compound 21 but broader anti-fibrotic effects than pirfenidone in mice with bleomycin-induced pulmonary fibro	15
Carnosine Augments the Efficacy of Pulmonary Rehabilitation in COPD: Insights from a Preclinical Model	15
GPER1Unravelling the effects of selective estrogen receptor modulators on colorectal cancer: a prognostic role for insulin-like growth factor binding protein-5.	14
Brief early life angiotensin-converting enzyme inhibition attenuates the diuretic response to saline loading in sheep with solitary functioning kidney	14
Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-γ axis	14
Double-edged mitophagy: balancing inflammation and resolution in lung disease	14
The role of microRNAs in pregnancies complicated by maternal diabetes	13
Transcriptomic and Functional Analysis of Fibroid Extracellular Vesicles	13
A new mechanism of arterial calcification in diabetes: interaction between H3K18 lactylation and CHI3L1	13
NaHCO3 loading causes increased arterial pressure and kidney damage in rats with chronic kidney disease	13
Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease	13
Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge	13
Role of circadian gene expression in the divergent effects of intermittent hypoxia and sleep fragmentation on blood pressure	13
ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE−/− mice	13
Urine-derived renal epithelial cells for deep phenotyping and transcriptomic response to therapy in Fabry disease	13
Retraction: Overexpression of TrpC5 promotes tumor metastasis via the HIF-1α/Twist signaling pathway in colon cancer	13
Endothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions	13
Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis	13
Umbilical cord mesenchymal stem cells from gestational diabetes show impaired ability to up-regulate paracellular permeability from sub-endothelial niche	13
G-protein-coupled receptor MAS deletion produces a preeclampsia-like phenotype in FVB/N mice	13
Serpina3c deficiency promotes obesity-related hypertriglyceridemia and inflammation through activation of the Hif1α-glycolysis axis in adipose tissue	13
Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy	12
Expression of Concern: Mitochondrial dynamic modulation exerts cardiometabolic protection in obese insulin-resistant rats	12
The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies	12
COPD: the role of neutrophils in inflammation, pathophysiology, and as drug targets	12
PE (0:0/14:0), an endogenous metabolite of the gut microbiota, exerts protective effects against sepsis-induced intestinal injury by modulating the AHR/CYP1A1 pathway	12
Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases	12
Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity	12
The complex genetic basis of fibromuscular dysplasia, a systemic arteriopathy associated with multiple forms of cardiovascular disease	12
Beyond αβ T cells: unlocking the potential of diverse immune cells in CAR modification	12
Regulation of Na+-K+-ATPase leads to disturbances of isoproterenol-induced cardiac dysfunction via interference of Ca2+-dependent cardiac metabolism	12
Novel mediators of idiopathic pulmonary fibrosis	12
Cancer and sepsis	11
Perimenopause-induced insulin resistance via 5-HT dysregulation	11
Disrupted renal clock and blood pressure rhythms in type 2 diabetic nephropathy	11
Elevated phenylacetylglutamine caused by gut dysbiosis associated with type 2 diabetes increases neutrophil extracellular traps formation and exacerbates brain infarction	11
The unfolded protein response and its activation by insulin in muscle are not altered by obesity or type 2 diabetes	11
Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease	11
RNA-binding protein HuR regulates the transition of septic AKI to CKD by modulating CD147	11
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis	11
Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice	11
HO-1 modulates obesity-related renal sodium metabolism via oxidative stress and Na/K-ATPase signaling	11
Differences in endothelial function between patients with Type 1 and Type 2 diabetes: effects of red blood cells and arginase	11
SMAD5 as a novel gene for familial pulmonary arterial hypertension	11
Hypertension: a lymphatic disease?	11
Correction: New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	11
Skeletal muscle dysfunction with advancing age	11
Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation	11