Clinical Science

Article	Citations
Measuring muscle protein synthesis in humans and the influence of nutritional state	490
Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities	320
Metal regulation of Mycobacterium tuberculosis SufB intein splicing at the host–pathogen crossroad	319
α-Adrenergic blockade prevented environmental temperature reduction-induced transient portal pressure surge in cirrhotic and portal hypertensive rats	104
Effect of metformin in a novel experimental model of peripheral artery disease	83
The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models	79
Loss of LCAT function aggravates metabolic-associated steatohepatitis (MASH) in golden Syrian hamster	62
Chronic stress and the IL-10-mediated immunoregulatory loop in the pathogenesis of periodontitis	61
Expression of Concern: Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression	61
Maintaining energy provision in the heart: the creatine kinase system in ischaemia–reperfusion injury and chronic heart failure	59
Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation	58
Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of CaV1.2 calcium channel in hypertension	58
Inhibition of CCL4 prevents renal inflammation and fibrosis in acute kidney injury	54
Cardiovascular research at the Heart of Clinical Science	53
Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice	49
Tetramethylpyrazine attenuates renal tubular epithelial cell ferroptosis in contrast-induced nephropathy by inhibiting transferrin receptor and intracellular reactive oxygen species	46
The multifactorial role of HDAC9 at the maternal–fetal interface in the pathogenesis of preeclampsia	46
Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep	44
Antiviral activities of hemp cannabinoids	43
Correction: Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C	41
ASGR1 induces neutrophil extracellular traps formation to exacerbate sepsis-induced myocardial injury and cardiac dysfunction through SLC7A11 ubiquitination	40
Maternal high-fat diet regulates offspring hepatic ABCG5 expression and cholesterol metabolism via the gut microbiota and its derived butyrate	39
Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis	36
Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury	33
Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction	32

Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients	31
Set7 methyltransferase roles in myocardial protection from chronic stressors	29
CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial–mesenchymal transition via inhibiting MDM2	29
Adverse effects of ovarian cryopreservation and auto-transplantation on ovarian grafts and quality of produced oocytes in a mouse model	29
Utility of preclinical models of altered maternal nutrition to support the developmental origins of health and disease hypothesis	28
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of lowering blood pressure	27
Correction: Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma	26
Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies	26
NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose	26
IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53	26
Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis	26
Circulating cell-free micro-RNA as biomarkers: from myocardial infarction to hypertension	25
The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy	25
Chronic pyridostigmine is antiarrhythmic in Spontaneously hypertensive rats (SHR) but detrimental in normotensive WKY rats	24
Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection	24
By what molecular mechanisms do social determinants impact cardiometabolic risk?	24
Retraction: Inhibition of mitochondrial fission as a novel therapeutic strategy to reduce mortality upon myocardial infarction	24
New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	23
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of increasing M2 macrophages	23
Serum proteomics links the cardiorespiratory biomarkers CTRC, OSM, and MMP-10 to exacerbation severity and number in patients with COPD	23
Expression of Concern: Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice	22
Piezo channels in JG cells do not regulate renin expression or renin release to the circulation	22
Advances in understanding lipid metabolism in oligodendrocyte development and neurodegenerative diseases	22
Molecular and cellular regulation of psoriatic inflammation	21
Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways	21
Fentanyl exposure during preconception and gestation permanently dysregulates endogenous opioid peptides and sympathoadrenal-medullary axis in the offspring	21
Platelets from older adults exhibit differences in mitochondrial function associated with impaired glucose metabolism	21
Correction: The vascular Na,K-ATPase: clinical implications in stroke, migraine, and hypertension	21
Human placental lipid content and lipid metabolic enzyme abundance in obesity and across gestation	20
ZNF827 pleiotropic cardiovascular risk locus involves regulation by Nuclear Factor-1 transcription factors	20
Enhanced STAT3/PIK3R1/mTOR signaling triggers tubular cell inflammation and apoptosis in septic-induced acute kidney injury: implications for therapeutic intervention	19
Correction: Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research	18
Cellular senescence and kidney aging	18
Endothelin and the tumor microenvironment: a finger in every pie	18
Vascular dysfunction in COVID-19 patients: update on SARS-CoV-2 infection of endothelial cells and the role of long non-coding RNAs	17
Impact of the natural female reproductive aging on the rat serum lipidome	17
High sodium promotes the secretion and synthesis of PTH through PiT-1-IKKβ pathway in parathyroid gland in vitro	17
The O-GlcNAc dichotomy: when does adaptation become pathological?	17
Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection	17
Participation of the spleen in the neuroinflammation after pilocarpine-induced status epilepticus: implications for epileptogenesis and epilepsy	17
Molecular regulators of defective placental and cardiovascular development in fetal growth restriction	16
Inflammatory liver diseases and susceptibility to sepsis	16
SDMA as a marker and mediator in cerebrovascular disease	16
Protective effect of mesenchymal stromal cells in diabetic nephropathy: the In vitro and In vivo role of the M-Sec-tunneling nanotubes	16
Placental ferroptosis and impaired fetal growth in symptomatic and asymptomatic SARS-CoV-2 infections	16
Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery	16
Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction	16
Endothelial TET2 deficiency exacerbates diabetic coronary microvascular dysfunction via CMPK2-mediated mitochondrial impairment	16
The novel AT2 receptor ligand, β-Pro7 Ang III, induces equivalent anti-fibrotic effects to Compound 21 but broader anti-fibrotic effects than pirfenidone in mice with bleomycin-induced pulmonary fibro	15
Carnosine Augments the Efficacy of Pulmonary Rehabilitation in COPD: Insights from a Preclinical Model	15

The emerging role of LRRK2 in tauopathies	15
Alveolar epithelial cells of lung fibrosis patients are susceptible to severe virus-induced injury	15
Double-edged mitophagy: balancing inflammation and resolution in lung disease	14
GPER1Unravelling the effects of selective estrogen receptor modulators on colorectal cancer: a prognostic role for insulin-like growth factor binding protein-5.	14
Brief early life angiotensin-converting enzyme inhibition attenuates the diuretic response to saline loading in sheep with solitary functioning kidney	14
Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-γ axis	14
Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis	13
Umbilical cord mesenchymal stem cells from gestational diabetes show impaired ability to up-regulate paracellular permeability from sub-endothelial niche	13
NaHCO3 loading causes increased arterial pressure and kidney damage in rats with chronic kidney disease	13
Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease	13
Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge	13
The role of microRNAs in pregnancies complicated by maternal diabetes	13
Transcriptomic and Functional Analysis of Fibroid Extracellular Vesicles	13
A new mechanism of arterial calcification in diabetes: interaction between H3K18 lactylation and CHI3L1	13
Urine-derived renal epithelial cells for deep phenotyping and transcriptomic response to therapy in Fabry disease	13
Retraction: Overexpression of TrpC5 promotes tumor metastasis via the HIF-1α/Twist signaling pathway in colon cancer	13
Endothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions	13
Role of circadian gene expression in the divergent effects of intermittent hypoxia and sleep fragmentation on blood pressure	13
ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE−/− mice	13
G-protein-coupled receptor MAS deletion produces a preeclampsia-like phenotype in FVB/N mice	13
Serpina3c deficiency promotes obesity-related hypertriglyceridemia and inflammation through activation of the Hif1α-glycolysis axis in adipose tissue	13
Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy	12
Expression of Concern: Mitochondrial dynamic modulation exerts cardiometabolic protection in obese insulin-resistant rats	12
The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies	12
COPD: the role of neutrophils in inflammation, pathophysiology, and as drug targets	12
PE (0:0/14:0), an endogenous metabolite of the gut microbiota, exerts protective effects against sepsis-induced intestinal injury by modulating the AHR/CYP1A1 pathway	12
Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases	12
Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity	12
The complex genetic basis of fibromuscular dysplasia, a systemic arteriopathy associated with multiple forms of cardiovascular disease	12
Beyond αβ T cells: unlocking the potential of diverse immune cells in CAR modification	12
Regulation of Na+-K+-ATPase leads to disturbances of isoproterenol-induced cardiac dysfunction via interference of Ca2+-dependent cardiac metabolism	12
Novel mediators of idiopathic pulmonary fibrosis	12
Cancer and sepsis	11
Perimenopause-induced insulin resistance via 5-HT dysregulation	11
Disrupted renal clock and blood pressure rhythms in type 2 diabetic nephropathy	11
Elevated phenylacetylglutamine caused by gut dysbiosis associated with type 2 diabetes increases neutrophil extracellular traps formation and exacerbates brain infarction	11
The unfolded protein response and its activation by insulin in muscle are not altered by obesity or type 2 diabetes	11
Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease	11
RNA-binding protein HuR regulates the transition of septic AKI to CKD by modulating CD147	11
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis	11
Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice	11
HO-1 modulates obesity-related renal sodium metabolism via oxidative stress and Na/K-ATPase signaling	11
Differences in endothelial function between patients with Type 1 and Type 2 diabetes: effects of red blood cells and arginase	11
SMAD5 as a novel gene for familial pulmonary arterial hypertension	11
Hypertension: a lymphatic disease?	11
Correction: New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	11
Skeletal muscle dysfunction with advancing age	11
Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation	11
When the liver is in poor condition, so is the heart – cardiac remodelling in MASH mouse models	10
Correction: Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway -Application to a biomarker for atherosclerosis	10
DY131 activates ERRγ/TFAM axis to protect against metabolic disorders and acute kidney injury	10
Iron and mitochondria in the susceptibility, pathogenesis and progression of COPD	10
Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease	10
Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma	10
Mechanistic insights into the development of severe fetal growth restriction	10
CGRP alleviates lipopolysaccharide-induced ARDS inflammation via the HIF-1α signaling pathway	10
Mechanism of protective actions of sparsentan in the kidney: lessons from studies in models of chronic kidney disease	10
The presence of xanthine dehydrogenase is crucial for the maturation of the rat kidneys	10
Intervention treatment reducing cellular senescence inhibits tubulointerstitial fibrosis in diabetic mice following acute kidney injury	10
Blood pressure reduction and anti-inflammatory macrophage augmentation attenuate uterine immune dysregulation and inflammation in mice with salt-sensitive hypertension	10
The ICU environment paradigm as a strategy to enhance the validity of delirium animal models	10
Sympathetic regulation of the host immune response to bacterial sepsis	10
Maternal glucagon-like peptide-1 is positively associated with fetal growth in pregnancies complicated with obesity	10
The long noncoding RNA Meg3 mediates TLR4-induced inflammation in experimental obstructive nephropathy	10
Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice	10
Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy	9
Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca2+ mishandling and atrial fibrosis in active immunization rabbit models	9
Destabilisation of T cell-dependent humoral immunity in sepsis	9
Autophagy in asthma and chronic obstructive pulmonary disease	9
Endothelin-1 receptor blockade impairs invasion patterns in engineered 3D high-grade serous ovarian cancer tumouroids	9
An emerging role for eosinophils as pro-angiogenic drivers of adipose tissue beiging	9
CircRBM23 regulates the switch between osteogenesis and adipogenesis of mesenchymal stem cells via sponging miR-338-3p	9
Placental syndromes and maternal cardiovascular health	9
The immunology of heart failure with preserved ejection fraction	9
Reduced REG3α in obesity and type 2 diabetes is linked to altered intestinal barrier homeostasis and inflammation	9
Combined aerobic and resistance exercise training restores perivascular adipose tissue function in the thoracic aorta of rats with heart failure	9
Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research	9
Chronic GPER activation prompted the proliferation of ileal stem cell in ovariectomized mice depending on Paneth cell–derived Wnt3	9
Circulating biomarkers associated with placental dysfunction and their utility for predicting fetal growth restriction	9
pH-sensor GPR68 plays a role in how dietary fibre lowers blood pressure in a preclinical model of hypertension	8

Persistent vascular congestion in male spontaneously hypertensive rats contributes to delayed recovery of renal function following renal ischemia perfusion compared with females	8
Aging and sinus node dysfunction: mechanisms and future directions	8
TNF/iNOS/NO pathway mediates host susceptibility to endothelial-dependent circulatory failure and death induced by betacoronavirus infection	8
Pathogenesis of pneumonia and acute lung injury	8
Circadian regulation of pulmonary disease: the importance of timing	8
Increased absorptive transcytosis and tight junction weakness in heart failure are equally corrected by exercise training and losartan	8
Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice	8
The death of a myth: Females are not resistant to acute kidney injury	8
Blood–brain barrier lesion – a novel determinant of autonomic imbalance in heart failure and the effects of exercise training	8
Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men	8
Maternal ketone supplementation throughout gestation improves neonatal cardiac dysfunction caused by perinatal iron deficiency	8
Down-regulation of ALDOB during metabolic reprogramming mediates malignant behavior in hepatocellular carcinoma and insensitivity to postoperative adjuvant transarterial chemoembolization	8
Nicotine promotes AngII-induced abdominal aortic aortopathies in female and male mice: role of sex hormones	8
Myeloid cell-specific deletion of epidermal growth factor receptor aggravates acute cardiac injury	8
Insight into the roles of lactylation in macrophages: functions and clinical implications	8
Physiological response to fetal intravenous lipid emulsion	8
CircUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis	7
Bile salt signaling and bile salt-based therapies in cardiometabolic disease	7
Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D1R expression	7
CXCL5 inhibition ameliorates acute kidney injury and prevents the progression from acute kidney injury to chronic kidney disease	7
Importance of the gut microbiota in mice with a ‘humanized’ bile acid pool	7
Renal hemodynamics underlie hepatorenal physiology in bile duct-ligated rats	7
Oncogenic plasmid DNA and liver injury agent dictates liver cancer development in a mouse model	7
Smoking-induced microbial dysbiosis in health and disease	7
PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB	7
New discoveries in bile acids, gut microbiota and host interactions in health and diseases	7
Correction: Mineralocorticoid receptor (MR) antagonist eplerenone and MR modulator balcinrenone prevent renal extracellular matrix remodeling and inflammation via the MR/proteoglycan/TLR4 pathway	7
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning	7
Th17 cell mediated oligodendrocyte precursor cell arrest drives hippocampal demyelination in diabetic cognitive dysfunction	7
Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition	7
Restoring lung renin-angiotensin system balance through blood pressure control	7
Dysregulated haemostasis in thrombo-inflammatory disease	7
Molecular drivers of osteogenesis imperfecta: a cellular and extracellular collagen disease	7
Acetylcholinesterase inhibitor therapy mitigates hypertension in lupus mice	7
Evaluating the role of 2-hydroxyestradiol in modulating TNF-α signaling and its implications in rheumatoid arthritis	7
Casting a wide NET: an update on uncontrolled NETosis in response to COVID-19 infection	7
Macula densa-specific NOS1 knockout determines susceptibility to ischemic acute kidney injury	6
Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage	6
Immune landscape of the kidney allograft in response to rejection	6
4-Octyl itaconate against septic cardiac injury by suppressing cardiac lymphatic vessel inflammation via the RhoA–ROCK1 signaling pathway	6
Reductions in angiotensin II type 2 receptor-mediated vasodilation contribute to increased angiotensin II vasoconstrictor sensitivity in women with preeclampsia history	6
Astrocytes at the intersection of ageing, obesity, and neurodegeneration	6
The nonindustrialised microbiome in a modern world	6
Non-mitogenic FGF19 mRNA-based therapy for the treatment of experimental metabolic dysfunction-associated steatotic liver disease (MASLD)	6
TLR2 and 4 signaling pathways are altered in macrophages from V30M TTR mice with down-regulated expression of chemokines	6
In vivo and ex vivo cardiovascular haemodynamic responses of preterm growth-restricted lambs to perinatal asphyxia	6
ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer	6
DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity	6
Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis	6
Role of mitochondria in endogenous renal repair	6
Exosome-mediated modulation of macrophage polarization and inflammation in early Klebsiella pneumoniae lung infections	6
Evaluating skeletal muscle wasting and weakness in models of critical illness	5
Targeting perilipin 5 ameliorates diabetic cardiomyopathy via regulating glycolysis and mitochondrial dynamics	5
Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome	5
Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity	5
Replacing bar graphs of continuous data with more informative graphics: are we making progress?	5
Tolerogenic dendritic cells immunotherapy protects against IgA nephropathy	5
β-Arrestin pathway activation by selective ATR1 agonism promotes calcium influx in podocytes, leading to glomerular damage	5
The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction	5
Magnetic resonance imaging reveals microemboli-mediated pathological changes in brain microstructure in diabetic rats: relevance to vascular cognitive impairment/dementia	5
Deciphering complexity of GPCR signaling and modulation: implications and perspectives for drug discovery	5
Distinct functional and molecular profiles between physiological and pathological atrial enlargement offer potential new therapeutic opportunities for atrial fibrillation	5
Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen	5
Retraction: Differential temporal inhibition of mitochondrial fission by Mdivi-1 exerts effective cardioprotection in cardiac ischemia/reperfusion injury	5
Excessive hypercholesterolemia in pregnancy impairs rat uterine artery function via activation of Toll-like receptor 4	5
Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics	5
Angiotensin II-induced cardiac fibrosis and dysfunction are exacerbated by deletion of cGKI in periostin+ myofibroblasts	5
Retraction: Prader–Willi region non-protein coding RNA 1 suppressed gastric cancer growth as a competing endogenous RNA of miR-425-5p	5
Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension	5
Mechanisms underlying immune-related adverse events during checkpoint immunotherapy	5
Untangling the role of tau in sex hormone responsive cancers: lessons learnt from Alzheimer's disease	5
Interactions between the intrarenal dopaminergic and the renin–angiotensin systems in the control of systemic arterial pressure	5
Correction: Perinatal iron restriction is associated with changes in neonatal cardiac function and structure in a sex-dependent manner	5