Clinical Science

Article	Citations
Increased angiotensin II formation in the brain modulates cardiovascular homeostasis and erythropoiesis	198
Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?	176
α-Adrenergic blockade prevented environmental temperature reduction-induced transient portal pressure surge in cirrhotic and portal hypertensive rats	172
Expression of Concern: Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression	168
Maintaining energy provision in the heart: the creatine kinase system in ischaemia–reperfusion injury and chronic heart failure	149
Metal regulation of Mycobacterium tuberculosis SufB intein splicing at the host–pathogen crossroad	140
Measuring muscle protein synthesis in humans and the influence of nutritional state	109
Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation	105
Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities	74
Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of CaV1.2 calcium channel in hypertension	69
The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models	64
Effect of metformin in a novel experimental model of peripheral artery disease	53
Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients	52
Cardiovascular research at the Heart of Clinical Science	47
Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury	46
Maternal high-fat diet regulates offspring hepatic ABCG5 expression and cholesterol metabolism via the gut microbiota and its derived butyrate	46
Osteoprotegerin regulates vascular function through syndecan-1 and NADPH oxidase-derived reactive oxygen species	44
Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis	43
Tetramethylpyrazine attenuates renal tubular epithelial cell ferroptosis in contrast-induced nephropathy by inhibiting transferrin receptor and intracellular reactive oxygen species	42
Correction: Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C	40
Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents	38
Oxytocin: much more than childbirth and milk letdown	38
Antiviral activities of hemp cannabinoids	38
Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice	38
Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep	38

Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease	36
CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial–mesenchymal transition via inhibiting MDM2	36
Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction	36
Vascular contributions to cognitive impairment and dementia: the emerging role of 20-HETE	35
Correction: Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma	34
Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice	34
Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection	33
New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	32
The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy	32
By what molecular mechanisms do social determinants impact cardiometabolic risk?	31
Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis	31
Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies	31
IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53	30
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of increasing M2 macrophages	30
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of lowering blood pressure	27
Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein	27
The traditional herbal formulation, Jianpiyifei II, reduces pulmonary inflammation induced by influenza A virus and cigarette smoke in mice	27
Utility of preclinical models of altered maternal nutrition to support the developmental origins of health and disease hypothesis	26
Circulating cell-free micro-RNA as biomarkers: from myocardial infarction to hypertension	26
Adverse effects of ovarian cryopreservation and auto-transplantation on ovarian grafts and quality of produced oocytes in a mouse model	25
Set7 methyltransferase roles in myocardial protection from chronic stressors	25
NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose	25
Endothelin and the tumor microenvironment: a finger in every pie	24
Enhanced STAT3/PIK3R1/mTOR signaling triggers tubular cell inflammation and apoptosis in septic-induced acute kidney injury: implications for therapeutic intervention	24
Piezo channels in JG cells do not regulate renin expression or renin release to the circulation	24
Molecular and cellular regulation of psoriatic inflammation	23
MicroRNAs as messengers of liver diseases: has the message finally been decrypted?	23
Correction: The vascular Na,K-ATPase: clinical implications in stroke, migraine, and hypertension	21
Expression of Concern: Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice	21
Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways	21
Cellular senescence and kidney aging	20
Paternal long-term PM2.5 exposure causes hypertension via increased renal AT1R expression and function in male offspring	20
Molecular mechanisms of anthracycline cardiovascular toxicity	20
Human placental lipid content and lipid metabolic enzyme abundance in obesity and across gestation	19
Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease	19
Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms	19
Promyelocytic leukemia protein: an atherosclerosis suppressor protein?	19
Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery	18
Correction: Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research	18
The O-GlcNAc dichotomy: when does adaptation become pathological?	18
SARS-CoV-2 spike protein causes cardiovascular disease independent of viral infection	17
Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-γ axis	17
Fifty years of research on the brain renin–angiotensin system: what have we learned?	17
Protective effect of mesenchymal stromal cells in diabetic nephropathy: the In vitro and In vivo role of the M-Sec-tunneling nanotubes	17
SDMA as a marker and mediator in cerebrovascular disease	17
Alveolar epithelial cells of lung fibrosis patients are susceptible to severe virus-induced injury	17
Nutrient regulation of inflammatory signalling in obesity and vascular disease	17
High sodium promotes the secretion and synthesis of PTH through PiT-1-IKKβ pathway in parathyroid gland in vitro	17
Participation of the spleen in the neuroinflammation after pilocarpine-induced status epilepticus: implications for epileptogenesis and epilepsy	17
Vascular dysfunction in COVID-19 patients: update on SARS-CoV-2 infection of endothelial cells and the role of long non-coding RNAs	16

Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction	16
Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis	16
The emerging role of LRRK2 in tauopathies	16
Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge	15
Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection	15
Brief early life angiotensin-converting enzyme inhibition attenuates the diuretic response to saline loading in sheep with solitary functioning kidney	15
Endothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions	15
Inflammatory liver diseases and susceptibility to sepsis	15
Klotho and calciprotein particles as therapeutic targets against accelerated ageing	15
The role of microRNAs in pregnancies complicated by maternal diabetes	15
G-protein-coupled receptor MAS deletion produces a preeclampsia-like phenotype in FVB/N mice	15
Molecular regulators of defective placental and cardiovascular development in fetal growth restriction	15
Serpina3c Deficiency Promotes Obesity-related Hypertriglyceridemia and Inflammation through Activation of the Hif1α-glycolysis Axis in Adipose Tissue	15
NaHCO3 loading causes increased arterial pressure and kidney damage in rats with chronic kidney disease	15
Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease	15
Human placental villous stromal extracellular matrix regulates fetoplacental angiogenesis in severe fetal growth restriction	14
Umbilical cord mesenchymal stem cells from gestational diabetes show impaired ability to up-regulate paracellular permeability from sub-endothelial niche	14
ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE−/− mice	14
The complex genetic basis of fibromuscular dysplasia, a systemic arteriopathy associated with multiple forms of cardiovascular disease	14
Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity	14
Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis	14
Regulation of Na+-K+-ATPase leads to disturbances of isoproterenol-induced cardiac dysfunction via interference of Ca2+-dependent cardiac metabolism	14
A new mechanism of arterial calcification in diabetes: interaction between H3K18 lactylation and CHI3L1	14
PE (0:0/14:0), an endogenous metabolite of the gut microbiota, exerts protective effects against sepsis-induced intestinal injury by modulating the AHR/CYP1A1 pathway	13
Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity	13
Microbiota transplants from feces or gut content attenuated portal hypertension and portosystemic collaterals in cirrhotic rats	13
Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases	13
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis	13
Novel mediators of idiopathic pulmonary fibrosis	13
Interactions between cardiology and oncology drugs in precision cardio-oncology	13
SMAD5 as a novel gene for familial pulmonary arterial hypertension	13
The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies	13
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability	13
Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy	13
Correction: New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	12
When the liver is in poor condition, so is the heart – cardiac remodelling in MASH mouse models	12
Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease	12
Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)	12
Differences in endothelial function between patients with Type 1 and Type 2 diabetes: effects of red blood cells and arginase	12
CGRP alleviates lipopolysaccharide-induced ARDS inflammation via the HIF-1α signaling pathway	12
Skeletal muscle dysfunction with advancing age	12
RNA-binding protein HuR regulates the transition of septic AKI to CKD by modulating CD147	12
Correction: Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway -Application to a biomarker for atherosclerosis	12
Cancer and sepsis	12
Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer	11
Epigenomic alterations in cancer: mechanisms and therapeutic potential	11
Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype	11
Mechanism of protective actions of sparsentan in the kidney: lessons from studies in models of chronic kidney disease	11
Maternal glucagon-like peptide-1 is positively associated with fetal growth in pregnancies complicated with obesity	11
Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation	11
Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice	11
The immunology of heart failure with preserved ejection fraction	11
Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease	11
Mechanistic insights into the development of severe fetal growth restriction	11
Emergent players in renovascular disease	11
DY131 activates ERRγ/TFAM axis to protect against metabolic disorders and acute kidney injury	11
Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis	11
Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice	11
Inhibition of HDAC3 protects against kidney cold storage/transplantation injury and allograft dysfunction	10
Intervention treatment reducing cellular senescence inhibits tubulointerstitial fibrosis in diabetic mice following acute kidney injury	10
Circulating biomarkers associated with placental dysfunction and their utility for predicting fetal growth restriction	10
A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis	10
Destabilisation of T cell-dependent humoral immunity in sepsis	10
The presence of xanthine dehydrogenase is crucial for the maturation of the rat kidneys	10
The long noncoding RNA Meg3 mediates TLR4-induced inflammation in experimental obstructive nephropathy	10
Autophagy in asthma and chronic obstructive pulmonary disease	10
Placental syndromes and maternal cardiovascular health	10
CircRBM23 regulates the switch between osteogenesis and adipogenesis of mesenchymal stem cells via sponging miR-338-3p	10
Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma	10
Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy	10
Iron and mitochondria in the susceptibility, pathogenesis and progression of COPD	10
Endothelin-1 receptor blockade impairs invasion patterns in engineered 3D high-grade serous ovarian cancer tumouroids	10
Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research	10
Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca2+ mishandling and atrial fibrosis in active immunization rabbit models	10
Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease	9
Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit modelin vivo	9
Chronic GPER activation prompted the proliferation of ileal stem cell in ovariectomized mice depending on Paneth cell–derived Wnt3	9
Adventitial recruitment of Lyve-1− macrophages drives aortic aneurysm in an angiotensin-2-based murine model	9
Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy	9
Sex differences in white adipose tissue expansion: emerging molecular mechanisms	9

Circadian regulation of pulmonary disease: the importance of timing	9
Urocortins as biomarkers in cardiovascular disease	9
Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice	9
Inhalation of dimethyl fumarate-encapsulated solid lipid nanoparticles attenuate clinical signs of experimental autoimmune encephalomyelitis and pulmonary inflammatory dysfunction in mice	9
Down-regulation of ALDOB during metabolic reprogramming mediates malignant behavior in hepatocellular carcinoma and insensitivity to postoperative adjuvant transarterial chemoembolization	9
Maternal ketone supplementation throughout gestation improves neonatal cardiac dysfunction caused by perinatal iron deficiency	9
Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT1a receptors in the proximal tubule of the kidney	8
Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat	8
Nicotine promotes AngII-induced abdominal aortic aortopathies in female and male mice: role of sex hormones	8
Myeloid cell-specific deletion of epidermal growth factor receptor aggravates acute cardiac injury	8
Pathogenesis of pneumonia and acute lung injury	8
C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT2, Mas and B2 receptors	8
Blood–brain barrier lesion – a novel determinant of autonomic imbalance in heart failure and the effects of exercise training	8
Persistent vascular congestion in male spontaneously hypertensive rats contributes to delayed recovery of renal function following renal ischemia perfusion compared with females	8
Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats	8
Mechanisms of podocyte injury and implications for diabetic nephropathy	8
High-volume endurance exercise training stimulates hematopoiesis by increasing ACE NH2-terminal activity	8
Physiological response to fetal intravenous lipid emulsion	8
Maternal intermittent fasting during pregnancy: a translational research challenge for an important clinical scenario	8
TNF/iNOS/NO pathway mediates host susceptibility to endothelial-dependent circulatory failure and death induced by betacoronavirus infection	8
Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice	8
Insight into the roles of lactylation in macrophages: functions and clinical implications	8
Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men	8
CXCL5 inhibition ameliorates acute kidney injury and prevents the progression from acute kidney injury to chronic kidney disease	8
Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury	7
Dysregulated haemostasis in thrombo-inflammatory disease	7
Smoking-induced microbial dysbiosis in health and disease	7
The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease	7
Restoring lung renin-angiotensin system balance through blood pressure control	7
Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D1R expression	7
Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling	7
PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB	7
Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition	7
Importance of the gut microbiota in mice with a ‘humanized’ bile acid pool	7
Correction: Mineralocorticoid receptor (MR) antagonist eplerenone and MR modulator balcinrenone prevent renal extracellular matrix remodeling and inflammation via the MR/proteoglycan/TLR4 pathway	7
Unravelling the tangled web of hypertension and cancer	7
Blocking of interleukin-1 suppresses angiotensin II-induced renal injury	7
Bile salt signaling and bile salt-based therapies in cardiometabolic disease	7
New discoveries in bile acids, gut microbiota and host interactions in health and diseases	7
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning	7
Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage	6
Oncogenic plasmid DNA and liver injury agent dictates liver cancer development in a mouse model	6
Casting a wide NET: an update on uncontrolled NETosis in response to COVID-19 infection	6
The nonindustrialised microbiome in a modern world	6
Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension	6
Updates in deep learning research in ophthalmology	6
Astrocytes at the intersection of ageing, obesity, and neurodegeneration	6
Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats	6
Splenectomy increases blood pressure and abolishes sex differences in renal T-regulatory cells in spontaneously hypertensive rats	6
DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity	6
The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction	6
TLR2 and 4 signaling pathways are altered in macrophages from V30M TTR mice with down-regulated expression of chemokines	6
Immune landscape of the kidney allograft in response to rejection	6
Non-mitogenic FGF19 mRNA-based therapy for the treatment of experimental metabolic dysfunction-associated steatotic liver disease (MASLD)	6
ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer	6
CircUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis	6
How dendritic cells sense and respond to viral infections	6
Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis	6
β-Arrestin pathway activation by selective ATR1 agonism promotes calcium influx in podocytes, leading to glomerular damage	5
Small extracellular vesicles derived from patients with persistent atrial fibrillation exacerbate arrhythmogenesis via miR-30a-5p	5
Role of mitochondria in endogenous renal repair	5
Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress	5
Magnetic resonance imaging reveals microemboli-mediated pathological changes in brain microstructure in diabetic rats: relevance to vascular cognitive impairment/dementia	5
Retraction: Prader–Willi region non-protein coding RNA 1 suppressed gastric cancer growth as a competing endogenous RNA of miR-425-5p	5
Replacing bar graphs of continuous data with more informative graphics: are we making progress?	5
Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity	5
Non-invasive prenatal diagnosis (NIPD): how analysis of cell-free DNA in maternal plasma has changed prenatal diagnosis for monogenic disorders	5
Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen	5
Mechanisms underlying immune-related adverse events during checkpoint immunotherapy	5
Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome	5
Hypoxic preconditioning in renal ischaemia–reperfusion injury: a review in pre-clinical models	5
Angiotensin II-induced cardiac fibrosis and dysfunction are exacerbated by deletion of cGKI in periostin+ myofibroblasts	5
Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia	5
Focal adhesion signaling: vascular smooth muscle cell contractility beyond calcium mechanisms	5
Correction: Perinatal iron restriction is associated with changes in neonatal cardiac function and structure in a sex-dependent manner	5
Excessive hypercholesterolemia in pregnancy impairs rat uterine artery function via activation of Toll-like receptor 4	5
Missing links — epigenetic regulators of the pancreatic cancer–associated inflammation	5
Interactions between the intrarenal dopaminergic and the renin–angiotensin systems in the control of systemic arterial pressure	5
Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics	5
Distinct functional and molecular profiles between physiological and pathological atrial enlargement offer potential new therapeutic opportunities for atrial fibrillation	5
Untangling the role of tau in sex hormone responsive cancers: lessons learnt from Alzheimer's disease	5