Clinical Science

Papers
(The median citation count of Clinical Science is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)
ArticleCitations
Emerging role of carbonic anhydrase inhibitors127
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer125
The complex role of adipokines in obesity, inflammation, and autoimmunity121
Pathogenesis of pneumonia and acute lung injury109
Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways100
The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease100
Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway91
M1/M2 macrophages and their overlaps – myth or reality?80
Mechanisms of podocyte injury and implications for diabetic nephropathy72
ACE2 and gut amino acid transport70
Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities63
Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP161
The immune niche of the liver57
Cholesterol metabolism: a new molecular switch to control inflammation53
Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway52
Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression52
ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV50
Cardiotoxic effects of angiogenesis inhibitors50
Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-1948
Inflammation: a putative link between phosphate metabolism and cardiovascular disease45
ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-1944
The GCN5: its biological functions and therapeutic potentials43
Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice40
Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis40
Gut microbiome dysbiosis alleviates the progression of osteoarthritis in mice40
Klotho and calciprotein particles as therapeutic targets against accelerated ageing40
ACE2: from protection of liver disease to propagation of COVID-1938
Epigenetic processes during preeclampsia and effects on fetal development and chronic health38
Correcting the imbalanced protective RAS in COVID-19 with angiotensin AT2-receptor agonists38
ACE2 in the renin–angiotensin system37
ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease37
Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis37
Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer’s disease36
Host cell glutamine metabolism as a potential antiviral target36
Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility35
Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes33
Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)33
Obesity-associated cardiovascular risk in women: hypertension and heart failure31
Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics30
Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor30
Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis30
Lipotoxicity: a driver of heart failure with preserved ejection fraction?29
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability29
Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice28
Aetiology of Type 2 diabetes in people with a ‘normal’ body mass index: testing the personal fat threshold hypothesis27
Clinical perspectives on vagus nerve stimulation: present and future27
SIRT7 restricts HBV transcription and replication through catalyzing desuccinylation of histone H3 associated with cccDNA minichromosome27
Increased susceptibility to dextran sulfate-induced mucositis of iron-overload β-thalassemia mice, another endogenous cause of septicemia in thalassemia26
Autophagy in asthma and chronic obstructive pulmonary disease26
Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease26
Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid26
Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis25
NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia25
CYP1B1 as a therapeutic target in cardio-oncology25
How accurate are citations of frequently cited papers in biomedical literature?24
Molecular mechanisms of anthracycline cardiovascular toxicity24
LncRNA HOTAIR modulates hepatitis B virus transcription and replication by enhancing SP1 transcription factor24
The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases24
Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis24
Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease23
Updates in deep learning research in ophthalmology23
No evidence for brain renin–angiotensin system activation during DOCA-salt hypertension22
Smoking-induced microbial dysbiosis in health and disease22
Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure22
The PAR-1 antagonist vorapaxar ameliorates kidney injury and tubulointerstitial fibrosis22
Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress21
Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids21
New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis21
Focal adhesion signaling: vascular smooth muscle cell contractility beyond calcium mechanisms21
Skeletal muscle redox signaling in rheumatoid arthritis20
SGLT2 inhibition versus sulfonylurea treatment effects on electrolyte and acid–base balance: secondary analysis of a clinical trial reaching glycemic equipoise: Tubular effects of SGLT2 inhibition in 20
Eicosanoid receptors as therapeutic targets for asthma19
Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction19
Early elimination of uremic toxin ameliorates AKI-to-CKD transition19
ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer19
Key role for EphB2 receptor in kidney fibrosis18
Cell-specific epigenetic changes in atherosclerosis18
Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure18
Interrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression18
KLHDC7B-DT aggravates pancreatic ductal adenocarcinoma development via inducing cross-talk between cancer cells and macrophages18
Gastrin, via activation of PPARα, protects the kidney against hypertensive injury17
P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model17
Vascular contributions to cognitive impairment and dementia: the emerging role of 20-HETE17
Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms17
Oxytocin signalling in dendritic cells regulates immune tolerance in the intestine and alleviates DSS-induced colitis17
Microbiota transplants from feces or gut content attenuated portal hypertension and portosystemic collaterals in cirrhotic rats17
How dendritic cells sense and respond to viral infections17
Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway17
IGF2 deficiency causes mitochondrial defects in skeletal muscle16
Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases16
Angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functions16
The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling16
Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension16
The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension16
Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor16
The emerging role of LRRK2 in tauopathies15
Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors15
CircUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis15
Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men15
ACE2, the kidney and the emergence of COVID-19 two decades after ACE2 discovery15
ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders14
Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents14
Non-invasive prenatal diagnosis (NIPD): how analysis of cell-free DNA in maternal plasma has changed prenatal diagnosis for monogenic disorders14
Phosphate and fibroblast growth factor 23 in diabetes14
Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease13
Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome13
By what molecular mechanisms do social determinants impact cardiometabolic risk?13
Protective role of kallistatin in renal fibrosis via modulation of Wnt/β-catenin signaling13
Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity13
Preeclampsia and syncytiotrophoblast membrane extracellular vesicles (STB-EVs)13
Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?13
Multicellular regulation of miR-196a-5p and miR-425-5 from adipose stem cell-derived exosomes and cardiac repair13
Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice13
Th2 cytokines-DUOX2-ROS-HMGB1 translocation axis is important in the pathogenesis of allergic rhinitis13
The pleiotropic effects of antithrombotic drugs in the metabolic–cardiovascular–neurodegenerative disease continuum: impact beyond reduced clotting13
A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice13
Unravelling the tangled web of hypertension and cancer13
The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease13
Vinpocetine protects against the development of experimental abdominal aortic aneurysms13
Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads12
In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system12
Acid sphingomyelinase promotes SGK1-dependent vascular calcification12
Novel mediators of idiopathic pulmonary fibrosis12
Methylglyoxal and glyoxalase 1—a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes12
Recent advances in understanding ion transport mechanisms in polycystic kidney disease12
Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy12
ACE2 activator diminazene aceturate exerts renoprotective effects in gentamicin-induced acute renal injury in rats12
Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection12
Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO/sGC/cGMP pathway12
Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection12
Maternal microvascular dysfunction during preeclamptic pregnancy12
SOX7 suppresses endothelial-to-mesenchymal transitions by enhancing VE-cadherin expression during outflow tract development11
Assessing hypothalamic pituitary gonadal function in reproductive disorders11
Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver11
Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth11
Inhalation of dimethyl fumarate-encapsulated solid lipid nanoparticles attenuate clinical signs of experimental autoimmune encephalomyelitis and pulmonary inflammatory dysfunction in mice11
Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis11
Cancer therapy-related cardiac dysfunction: is endothelial dysfunction at the heart of the matter?11
Asthma and obesity: endotoxin another insult to add to injury?11
Adeno-associated viral (AAV) vector-mediated therapeutics for diabetic cardiomyopathy – current and future perspectives11
Dysregulated haemostasis in thrombo-inflammatory disease11
Genetic and epigenetic regulation of the non-muscle myosin light chain kinase isoform by lung inflammatory factors and mechanical stress10
Inhibition of HDAC3 protects against kidney cold storage/transplantation injury and allograft dysfunction10
Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype10
Autoimmune-mediated renal disease and hypertension10
AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress10
L-Glutamine alleviates osteoarthritis by regulating lncRNA-NKILA expression through the TGF-β1/SMAD2/3 signalling pathway10
Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit modelin vivo10
Developmental programming of cardiovascular function: a translational perspective10
Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload10
Protective role of serpina3c as a novel thrombin inhibitor against atherosclerosis in mice10
Bortezomib limits renal allograft interstitial fibrosis by inhibiting NF-κB/TNF-α/Akt/mTOR/P70S6K/Smurf2 pathway via IκBα protein stabilization10
Sex differences in white adipose tissue expansion: emerging molecular mechanisms10
Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta10
High-density lipoprotein’s vascular protective functions in metabolic and cardiovascular disease – could extracellular vesicles be at play?10
Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling10
Cardiovascular toxicity of angiogenesis inhibitors and immune checkpoint inhibitors: synergistic anti-tumour effects at the cost of increased cardiovascular risk?10
The complex genetic basis of fibromuscular dysplasia, a systemic arteriopathy associated with multiple forms of cardiovascular disease10
Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat10
Vascular dysfunction in COVID-19 patients: update on SARS-CoV-2 infection of endothelial cells and the role of long non-coding RNAs9
Novel pharmacological approaches in abdominal aortic aneurysm9
DUSP12 acts as a novel endogenous protective signal against hepatic ischemia–reperfusion damage by inhibiting ASK1 pathway9
Human placental villous stromal extracellular matrix regulates fetoplacental angiogenesis in severe fetal growth restriction9
Murine endometrial-derived mesenchymal stem cells suppress experimental autoimmune encephalomyelitis depending on indoleamine-2,3-dioxygenase expression9
EB2 promotes hepatocellular carcinoma proliferation and metastasis via MAPK/ERK pathway by modulating microtubule dynamics9
C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT2, Mas and B2 receptors9
Mechanisms of immune aging in HIV9
Metabolism in atherosclerotic plaques: immunoregulatory mechanisms in the arterial wall9
The negative regulation of gene expression by microRNAs as key driver of inducers and repressors of cardiomyocyte differentiation9
Mechanistic insights into the development of severe fetal growth restriction9
Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway9
Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease9
Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases9
Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen9
A time to heal: microRNA and circadian dynamics in cutaneous wound repair9
Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection9
The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeutic option for patients with Type 2 diabetes and chronic kidney disease9
Epigenetic modifications of the renin–angiotensin system in cardiometabolic diseases9
Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia9
Blocking of interleukin-1 suppresses angiotensin II-induced renal injury9
Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT1a receptors in the proximal tubule of the kidney9
AT2R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet8
Paternal long-term PM2.5 exposure causes hypertension via increased renal AT1R expression and function in male offspring8
Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs8
Systematic online living evidence summaries: emerging tools to accelerate evidence synthesis8
Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis8
Interactions between cardiology and oncology drugs in precision cardio-oncology8
Status of biomarkers for the identification of stable or vulnerable plaques in atherosclerosis8
Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease8
The vascular Na,K-ATPase: clinical implications in stroke, migraine, and hypertension7
Vincristine attenuates cardiac fibrosis through the inhibition of NLRP3 inflammasome activation7
Neurochemical effects of sepsis on the brain7
Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats7
SARS-CoV-2 spike protein causes cardiovascular disease independent of viral infection7
Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries7
Exposure to cigarette smoke precipitates simple hepatosteatosis to NASH in high-fat diet fed mice by inducing oxidative stress7
WNT1-inducible signaling pathway protein 1 regulates kidney inflammation through the NF-κB pathway7
Brain ACE2 activation following brain aminopeptidase A blockade by firibastat in salt-dependent hypertension7
A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases7
G-protein-coupled receptor kinase 4 causes renal angiotensin II type 2 receptor dysfunction by increasing its phosphorylation7
CRIP1 expression in monocytes related to hypertension7
Brain angiotensin system: a new promise in the management of epilepsy?7
The leaky gut and the gut microbiome in sepsis – targets in research and treatment7
Sympathetic neural responses in heart failure during exercise and after exercise training7
The traditional herbal formulation, Jianpiyifei II, reduces pulmonary inflammation induced by influenza A virus and cigarette smoke in mice7
Circulating biomarkers associated with placental dysfunction and their utility for predicting fetal growth restriction7
ACE2 gene transfer ameliorates vasoreparative dysfunction in CD34+ cells derived from diabetic older adults7
Antiviral activities of hemp cannabinoids7
Increased angiotensin II formation in the brain modulates cardiovascular homeostasis and erythropoiesis7
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-197
Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis7
Screening for in vitro systematic reviews: a comparison of screening methods and training of a machine learning classifier7
Hypoxic preconditioning in renal ischaemia–reperfusion injury: a review in pre-clinical models7
The nonindustrialised microbiome in a modern world7
Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage7
Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats6
Therapeutic use of calpeptin in COVID-19 infection6
Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice6
Genetically inducing renal lymphangiogenesis attenuates hypertension in mice6
TNF/iNOS/NO pathway mediates host susceptibility to endothelial-dependent circulatory failure and death induced by betacoronavirus infection6
Persistent vascular congestion in male spontaneously hypertensive rats contributes to delayed recovery of renal function following renal ischemia perfusion compared with females6
Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research6
Stress signaler p38 mitogen-activated kinase activation: a cause for concern?6
β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto–Kakizaki rat6
Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm6
Osteoprotegerin regulates vascular function through syndecan-1 and NADPH oxidase-derived reactive oxygen species6
The double sides of NLRP3 inflammasome activation in sepsis6
Targeting skeletal muscle mitochondrial health in obesity6
Changes in the expression and functional activities of Myosin II isoforms in human hyperplastic prostate6
The biodistribution of placental and fetal extracellular vesicles during pregnancy following placentation6
Letter to the Editor: Brain renin–angiotensin system and liver-directed siRNA targeted to angiotensinogen6
Casting a wide NET: an update on uncontrolled NETosis in response to COVID-19 infection6
Defining the molecular underpinnings controlling cardiomyocyte proliferation6
Flavonoid derivative DMXAA attenuates cisplatin-induced acute kidney injury independent of STING signaling6
Youth versus adult-onset type 2 diabetic kidney disease: Insights into currently known structural differences and the potential underlying mechanisms6
Interactions between the intrarenal dopaminergic and the renin–angiotensin systems in the control of systemic arterial pressure6
Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy6
Cellular senescence and kidney aging6
Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice5
Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer5
Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK5
Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats5
Epigenomic alterations in cancer: mechanisms and therapeutic potential5
Cancer and sepsis5
Inhibition of monoamine oxidase B reduces atherosclerosis and fatty liver in mice5
The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models5
Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein5
Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia5
Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities5
The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies5
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