OOIR: Observatory of International Research

Papers

(The TQCC of Cell Calcium is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Store-operated ion channels: A growing family ?	84
Altered composition of the mitochondrial Ca2+uniporter in the failing human heart	71
TRPM7 in neurodevelopment and therapeutic prospects for neurodegenerative disease	62
PDX1, a transcription factor essential for organ differentiation, regulates SERCA-dependent Ca2+ homeostasis in sensory neurons	61
Toll-like receptor 4 activation enhances Orai1-mediated calcium signal promoting cytokine production in spinal astrocytes.	53
Handling a mature calcium signature through optogenetics improves the differentiation of primary murine myotubes	51
Opening Orai's to see B-yond current paradigms	50
Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using an In vitro Platform for Improving Insulin Therapy	39
Modalities of cell death, survival and adaptation: The role of the Ca2+-signaling toolkit	31
Editorial Board	28
Channeling hope for uranium-induced kidney damage and beyond with TRPML1	27
TRPV2 inhibitor tranilast prevents atrial fibrillation in rat models of pulmonary hypertension	26
Injury-induced Erk1/2 signaling tissue-specifically interacts with Ca2+ activity and is necessary for regeneration of spinal cord and skeletal muscle	26
Structural insights into the TRPV4-RhoA complex offer clues to solve the puzzle of TRPV4 channelopathies	26
Resolving the heteromeric composition and macromolecular environment of TRPC channels in the brain	25
Rendezvous with PI(3,5)P2 — A rapalog gets caught opening TRPML1	25
Editorial Board	24
Calcium influx into astrocytes plays a pivotal role in inflammation-driven behaviors	24
Ca2+-activated chloride channel ANO1: A new regulator of osteoclast function	24
Insulin-induced palmitoylation regulates the Cardiac Na+/Ca2+ exchanger NCX1	23
Probing single molecule mechanical interactions of syntaxin 1A with native synaptobrevin 2 residing on a secretory vesicle	23
Editorial Board	21
Structural snapshots of the mechanism of TRPV2 channel activation by small-molecule agonists	20
Characterization of cell type-specific S100B expression in the mouse olfactory bulb	20
Synergy of uncoupling proteins (1 and 2) with mitochondrial Ca2+ uptake machinery potentiate mitochondrial uncoupling	20

Polarity of action in salivary gland acinar cells: Local and preferential Ca2+ signalling	19
Editorial Board	19
A KRAP(y) job: Defining the localization of active IP3R	19
NAADP receptors: A one-two.	18
T-type channels in cancer cells: Driving in reverse	18
TRP channels: Intestinal bloating TRiPs up pathogen avoidance	18
Into the spotlight: RGK proteins in skeletal muscle	18
The sigma 1 receptor: A local media influencer	18
ZnT1 is a neuronal Zn2+/Ca2+ exchanger	18
Insulin-like growth factor-1 regulates the mechanosensitivity of chondrocytes by modulating TRPV4	17
Presynaptic-like mechanisms and the control of insulin secretion in pancreatic β-cells.	17
Dynamin 1 controls vesicle size and endocytosis at hippocampal synapses	17
TRPV4 and TRPC1 channels mediate the response to tensile strain in mouse Müller cells	17
Is CD38 involved in Ca2+ signalling elicited by activation of T cell receptors?	16
LIPID transfer proteins regulate store-operated calcium entry via control of plasma membrane phosphoinositides	16
Regulating calcium flux through AMPA glutamate receptors	15
Stretching the role of TMEM63a to gatekeeping Ca2+ release in pancreatic acinar cells	15
Editorial Board	15
In the right place at the right time: ROS and Ca2+ are allies in the battle for survival	15
Cardiac Na-Ca exchanger “tunes-out” at high intracellular [Na]	15
Mitochondrial reactive oxygen species in physiology and disease	15
Lysosomal potassium channels	14
ELD607 specifically traffics Orai1 to the lysosome leading to inhibition of store operated calcium entry	13
Arriving at the next level of complexity in IP3R and SOCE signaling	13
Duchenne muscular dystrophy skeletal muscle cells derived from human induced pluripotent stem cells recapitulate various calcium dysregulation pathways	13
Ca2+ as the prime trigger of aerobic glycolysis in astrocytes	12
Two-photon calcium imaging of seizures in awake, head-fixed mice	12
The physiological roles of anoctamin2/TMEM16B and anoctamin1/TMEM16A in chemical senses	12
Calcium signal modulation in breast cancer aggressiveness	12
Understanding IP3R channels: From structural underpinnings to ligand-dependent conformational landscape	12
Exploring the Li+ transporting mutant of NCX_Mj for assigning ion binding sites of mitochondrial NCLX	12
Pivotal role of the ORAI3-STIM2 complex in the control of mitotic death and prostate cancer cell cycle progression	11
Potential of targeting host cell calcium dynamics to curtail SARS-CoV-2 infection and COVID-19 pathogenesis	11
Unveiling the intricate role of S100A1 in regulating RyR1 activity: A commentary on “Structural insights into the regulation of RyR1 by S100A1”	11
IP3 receptor trafficking at the ER-mitochondria contacts impacts on mitochondrial Ca2+ homeostasis and metabolism	11
Acidic Ca2+ stores and immune-cell function	11
The role of potassium and host calcium signaling in Toxoplasma gondii egress	11
Modulators of TRPM7 and its potential as a drug target for brain tumours	11
Calcium signalling in hepatic metabolism: Health and diseases	10
Structural and functional conservation of the activating Ca2+ binding site in inositol 1,4.5-trisphosphate and ryanodine receptors	10
Cristae junction as a fundamental switchboard for mitochondrial ion signaling and bioenergetics	10
Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells	10
Commentary on: Li et al.; Ca2+ transients on the T cell surface trigger rapid integrin activation in a timescale of seconds. Nature Communications (2024)	10
Interplay between calcium and endoplasmic reticulum stress	10
Too much of a good thing: The case of SOCE in cellular apoptosis	10
Ca2+ handling at the mitochondria-ER contact sites in neurodegeneration	10
Injection of luteinizing hormone or human chorionic gonadotropin increases calcium excretion and serum PTH in males	9
Role of TRPM7 kinase in cancer	9
STIM1: A new player in nuclear dynamics? Lessons learnt from tubular aggregate myopathy	9
Genomic approachesidentifySTT4 as a new component in glucose-induced activation of yeast plasma membrane H+-ATPase	9

Regulation of the tubulin polymerization-promoting protein by Ca2+/S100 proteins	9
Editorial Board	9
pH regulating mechanisms of astrocytes: A critical component in physiology and disease of the brain	9
Distinct properties of Ca2+ efflux from brain, heart and liver mitochondria: The effects of Na+, Li+ and the mitochondrial Na+/Ca2+ exchange inhibitor CGP37157	9
Ca²⁺ signaling in myenteric interstitial cells of Cajal (ICC-MY) and their role as conditional pacemakers in the colon	9
Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7	9
Roles of cADPR and NAADP in pancreatic beta cell signaling	9
The many facets of TMEM63/OCaR proteins as mechanosensitive channels in lysosomes, NAADP signaling and beyond	9
Ionic signalling (beyond calcium) in the nervous system: Physiology and pathophysiology	8
NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain microvascular endothelial cells	8
Effects of the IQ1 motif of Drosophila myosin-5 on the calcium interaction of calmodulin	8
A role for lysosomal calcium channels in mitigating mitochondrial damage and oxidative stress	8
TRPC1 channels regulate the activation of pancreatic stellate cells through ERK1/2 and SMAD2 pathways and perpetuate their pressure-mediated activation	8
Development of chemical tools based on GSK-7975A to study store-operated calcium entry in cells	8
Orai1 is in neurons: Reply to “where have all the Orais gone?”	8
Relevance of lysosomal Ca2+ signalling machinery in cancer	8
Characterization of a functional Ca2+ toolkit in urine-derived stem cells and derived skeletal muscle cells	8
α-Synuclein emerges as a potent regulator of VDAC-facilitated calcium transport	8
Editorial Board	8
Astrocytic mitochondria in adult mouse brain slices show spontaneous calcium influx events with unique properties	8
Distinct pools of synaptic vesicles are released by different calcium channels	8
Corrigendum to “Modulating TRPV4 channels with paclitaxel and lithium” [Cell Calcium 91 (2020) 102266]	8
Hydrophobic interactions within the C terminus pole helices tunnel regulate calcium-dependent inactivation of TRPC3 in a calmodulin-dependent manner	8
Pan-cancer analysis reveals the prognostic gene CASR suppresses tumor progression and epithelial–mesenchymal transition in renal clear cell carcinoma	8
Investigating the landscape of intracellular [Ca2+] in live cells by rapid photoactivated cross-linking of calmodulin-protein interactions	7
Ca2+ signalling system initiated by endoplasmic reticulum stress stimulates PERK activation	7
Heterogeneity of the endoplasmic reticulum Ca2+ store determines colocalization with mitochondria	7
TRPA1 channel: New kid in the ‘neurovascular coupling’ town	7
Mitochondria-ER contacts and glucose: the powerhouse of Alzheimer's disease?	7
Editorial Board	7
Boosting ER-mitochondria calcium transfer to treat Wolfram syndrome	7
It takes two to Tango: Two gates orchestrate the opening of human TRPM2	7
MICU1 and MICU2 potentiation of Ca2+ uptake by the mitochondrial Ca2+ uniporter of Trypanosoma cruzi and its inhibition by Mg2+	7
Enhanced Ca2+ handling in thioglycolate-elicited peritoneal macrophages	7
Analysis of neuronal Ca2+ handling properties by combining perforated patch clamp recordings and the added buffer approach	7
Getting old without type 2 IP3 receptors	7
Multi-neurotransmitter regulation of neural firing via coincidence of parallel G-protein signals	7
The ins and outs of virus trafficking through acidic Ca2+ stores	7
Blockage of transient receptor potential vanilloid 4 prevents postoperative atrial fibrillation by inhibiting NLRP3-inflammasome in sterile pericarditis mice	7
How do MICUs gate the mitochondrial calcium uniporter?	7
When day meets night: Subsiding calcium signalling translates daylight into new neurones	7
The multifaceted role of SOCE in central synapses	7
Dyclonine inhibition of TRPV3: From functional discovery to structural insight	7
Engulf and digest – TRPM7 as key regulator of macrophage phagosome maturation	7