Cell Calcium

Article	Citations
Store-operated ion channels: A growing family ?	84
Altered composition of the mitochondrial Ca2+uniporter in the failing human heart	71
TRPM7 in neurodevelopment and therapeutic prospects for neurodegenerative disease	62
PDX1, a transcription factor essential for organ differentiation, regulates SERCA-dependent Ca2+ homeostasis in sensory neurons	61
Toll-like receptor 4 activation enhances Orai1-mediated calcium signal promoting cytokine production in spinal astrocytes.	53
Handling a mature calcium signature through optogenetics improves the differentiation of primary murine myotubes	51
Opening Orai's to see B-yond current paradigms	50
Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using an In vitro Platform for Improving Insulin Therapy	39
Modalities of cell death, survival and adaptation: The role of the Ca2+-signaling toolkit	31
Editorial Board	28
Channeling hope for uranium-induced kidney damage and beyond with TRPML1	27
TRPV2 inhibitor tranilast prevents atrial fibrillation in rat models of pulmonary hypertension	26
Injury-induced Erk1/2 signaling tissue-specifically interacts with Ca2+ activity and is necessary for regeneration of spinal cord and skeletal muscle	26
Structural insights into the TRPV4-RhoA complex offer clues to solve the puzzle of TRPV4 channelopathies	26
Resolving the heteromeric composition and macromolecular environment of TRPC channels in the brain	25
Rendezvous with PI(3,5)P2 — A rapalog gets caught opening TRPML1	25
Editorial Board	24
Calcium influx into astrocytes plays a pivotal role in inflammation-driven behaviors	24
Ca2+-activated chloride channel ANO1: A new regulator of osteoclast function	24
Insulin-induced palmitoylation regulates the Cardiac Na+/Ca2+ exchanger NCX1	23
Probing single molecule mechanical interactions of syntaxin 1A with native synaptobrevin 2 residing on a secretory vesicle	23
Editorial Board	21
Structural snapshots of the mechanism of TRPV2 channel activation by small-molecule agonists	20
Characterization of cell type-specific S100B expression in the mouse olfactory bulb	20
Synergy of uncoupling proteins (1 and 2) with mitochondrial Ca2+ uptake machinery potentiate mitochondrial uncoupling	20

Editorial Board	19
A KRAP(y) job: Defining the localization of active IP3R	19
Polarity of action in salivary gland acinar cells: Local and preferential Ca2+ signalling	19
TRP channels: Intestinal bloating TRiPs up pathogen avoidance	18
Into the spotlight: RGK proteins in skeletal muscle	18
The sigma 1 receptor: A local media influencer	18
ZnT1 is a neuronal Zn2+/Ca2+ exchanger	18
NAADP receptors: A one-two.	18
T-type channels in cancer cells: Driving in reverse	18
Presynaptic-like mechanisms and the control of insulin secretion in pancreatic β-cells.	17
Dynamin 1 controls vesicle size and endocytosis at hippocampal synapses	17
TRPV4 and TRPC1 channels mediate the response to tensile strain in mouse Müller cells	17
Insulin-like growth factor-1 regulates the mechanosensitivity of chondrocytes by modulating TRPV4	17
Is CD38 involved in Ca2+ signalling elicited by activation of T cell receptors?	16
LIPID transfer proteins regulate store-operated calcium entry via control of plasma membrane phosphoinositides	16
Regulating calcium flux through AMPA glutamate receptors	15
Stretching the role of TMEM63a to gatekeeping Ca2+ release in pancreatic acinar cells	15
Editorial Board	15
In the right place at the right time: ROS and Ca2+ are allies in the battle for survival	15
Cardiac Na-Ca exchanger “tunes-out” at high intracellular [Na]	15
Mitochondrial reactive oxygen species in physiology and disease	15
Lysosomal potassium channels	14
ELD607 specifically traffics Orai1 to the lysosome leading to inhibition of store operated calcium entry	13
Arriving at the next level of complexity in IP3R and SOCE signaling	13
Duchenne muscular dystrophy skeletal muscle cells derived from human induced pluripotent stem cells recapitulate various calcium dysregulation pathways	13
Ca2+ as the prime trigger of aerobic glycolysis in astrocytes	12
Two-photon calcium imaging of seizures in awake, head-fixed mice	12
The physiological roles of anoctamin2/TMEM16B and anoctamin1/TMEM16A in chemical senses	12
Calcium signal modulation in breast cancer aggressiveness	12
Understanding IP3R channels: From structural underpinnings to ligand-dependent conformational landscape	12
Exploring the Li+ transporting mutant of NCX_Mj for assigning ion binding sites of mitochondrial NCLX	12
Unveiling the intricate role of S100A1 in regulating RyR1 activity: A commentary on “Structural insights into the regulation of RyR1 by S100A1”	11
IP3 receptor trafficking at the ER-mitochondria contacts impacts on mitochondrial Ca2+ homeostasis and metabolism	11
Acidic Ca2+ stores and immune-cell function	11
The role of potassium and host calcium signaling in Toxoplasma gondii egress	11
Modulators of TRPM7 and its potential as a drug target for brain tumours	11
Pivotal role of the ORAI3-STIM2 complex in the control of mitotic death and prostate cancer cell cycle progression	11
Potential of targeting host cell calcium dynamics to curtail SARS-CoV-2 infection and COVID-19 pathogenesis	11
Cristae junction as a fundamental switchboard for mitochondrial ion signaling and bioenergetics	10
Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells	10
Commentary on: Li et al.; Ca2+ transients on the T cell surface trigger rapid integrin activation in a timescale of seconds. Nature Communications (2024)	10
Interplay between calcium and endoplasmic reticulum stress	10
Too much of a good thing: The case of SOCE in cellular apoptosis	10
Ca2+ handling at the mitochondria-ER contact sites in neurodegeneration	10
Calcium signalling in hepatic metabolism: Health and diseases	10
Structural and functional conservation of the activating Ca2+ binding site in inositol 1,4.5-trisphosphate and ryanodine receptors	10
Injection of luteinizing hormone or human chorionic gonadotropin increases calcium excretion and serum PTH in males	9
Role of TRPM7 kinase in cancer	9
STIM1: A new player in nuclear dynamics? Lessons learnt from tubular aggregate myopathy	9
Genomic approachesidentifySTT4 as a new component in glucose-induced activation of yeast plasma membrane H+-ATPase	9

Regulation of the tubulin polymerization-promoting protein by Ca2+/S100 proteins	9
Editorial Board	9
pH regulating mechanisms of astrocytes: A critical component in physiology and disease of the brain	9
Distinct properties of Ca2+ efflux from brain, heart and liver mitochondria: The effects of Na+, Li+ and the mitochondrial Na+/Ca2+ exchange inhibitor CGP37157	9
Ca²⁺ signaling in myenteric interstitial cells of Cajal (ICC-MY) and their role as conditional pacemakers in the colon	9
Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7	9
Roles of cADPR and NAADP in pancreatic beta cell signaling	9
The many facets of TMEM63/OCaR proteins as mechanosensitive channels in lysosomes, NAADP signaling and beyond	9
Effects of the IQ1 motif of Drosophila myosin-5 on the calcium interaction of calmodulin	8
TRPC1 channels regulate the activation of pancreatic stellate cells through ERK1/2 and SMAD2 pathways and perpetuate their pressure-mediated activation	8
Ionic signalling (beyond calcium) in the nervous system: Physiology and pathophysiology	8
NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain microvascular endothelial cells	8
A role for lysosomal calcium channels in mitigating mitochondrial damage and oxidative stress	8
Development of chemical tools based on GSK-7975A to study store-operated calcium entry in cells	8
Characterization of a functional Ca2+ toolkit in urine-derived stem cells and derived skeletal muscle cells	8
Orai1 is in neurons: Reply to “where have all the Orais gone?”	8
Relevance of lysosomal Ca2+ signalling machinery in cancer	8
α-Synuclein emerges as a potent regulator of VDAC-facilitated calcium transport	8
Editorial Board	8
Distinct pools of synaptic vesicles are released by different calcium channels	8
Hydrophobic interactions within the C terminus pole helices tunnel regulate calcium-dependent inactivation of TRPC3 in a calmodulin-dependent manner	8
Astrocytic mitochondria in adult mouse brain slices show spontaneous calcium influx events with unique properties	8
Corrigendum to “Modulating TRPV4 channels with paclitaxel and lithium” [Cell Calcium 91 (2020) 102266]	8
Pan-cancer analysis reveals the prognostic gene CASR suppresses tumor progression and epithelial–mesenchymal transition in renal clear cell carcinoma	8
Dyclonine inhibition of TRPV3: From functional discovery to structural insight	7
Engulf and digest – TRPM7 as key regulator of macrophage phagosome maturation	7
Investigating the landscape of intracellular [Ca2+] in live cells by rapid photoactivated cross-linking of calmodulin-protein interactions	7
Ca2+ signalling system initiated by endoplasmic reticulum stress stimulates PERK activation	7
Heterogeneity of the endoplasmic reticulum Ca2+ store determines colocalization with mitochondria	7
TRPA1 channel: New kid in the ‘neurovascular coupling’ town	7
Mitochondria-ER contacts and glucose: the powerhouse of Alzheimer's disease?	7
Editorial Board	7
Boosting ER-mitochondria calcium transfer to treat Wolfram syndrome	7
It takes two to Tango: Two gates orchestrate the opening of human TRPM2	7
MICU1 and MICU2 potentiation of Ca2+ uptake by the mitochondrial Ca2+ uniporter of Trypanosoma cruzi and its inhibition by Mg2+	7
Enhanced Ca2+ handling in thioglycolate-elicited peritoneal macrophages	7
Analysis of neuronal Ca2+ handling properties by combining perforated patch clamp recordings and the added buffer approach	7
Getting old without type 2 IP3 receptors	7
Multi-neurotransmitter regulation of neural firing via coincidence of parallel G-protein signals	7
The ins and outs of virus trafficking through acidic Ca2+ stores	7
Blockage of transient receptor potential vanilloid 4 prevents postoperative atrial fibrillation by inhibiting NLRP3-inflammasome in sterile pericarditis mice	7
How do MICUs gate the mitochondrial calcium uniporter?	7
When day meets night: Subsiding calcium signalling translates daylight into new neurones	7
The multifaceted role of SOCE in central synapses	7
Two-pore channels (TPCs) acts as a hub for excitation-contraction coupling, metabolism and cardiac hypertrophy signalling	6
Calreticulin regulates hepatic stellate cell activation through modulating TGF-beta-induced Smad signaling	6
Attenuation of the extracellular matrix increases the number of synapses but suppresses synaptic plasticity through upregulation of SK channels	6
Loss of PKD1 and PKD2 share common effects on intracellular Ca2+ signaling	6
SERCA2 phosphorylation at the heart of the disease	6
Neighbourhood Watch: Two-pore-2 channels talking to IP3 receptors	6
Presenilin 1 is a direct regulator of the cardiac sarco/endoplasmic reticulum calcium pump	6
The Mitochondrial Ca2+ import complex is altered in ADPKD	6
Orai1/STIMs modulators in pulmonary vascular diseases	6
Editorial Board	6
SERCA-1 conformational change exerted by the Ca2+-channel blocker diltiazem affects mammalian skeletal muscle function	6
Epithelial Anoctamins	6
Ryanodine receptor-mediated Ca2+ release and atlastin-2 GTPase activity contribute to IP3-induced dendritic Ca2+ signals in primary hippocampal neurons	6
IP3-dependent Ca2+ signals are tightly controlled by Cavβ3, but not by Cavβ1, 2 and 4	6
Dual function of the choroid plexus: Cerebrospinal fluid production and control of brain ion homeostasis	5
MICU1 and MICU2, two peas in a pod or entirely different fruits?	5
p85α regulatory subunit isoform controls PI3-kinase and TRPC6 membrane translocation	5
The IP3 receptor-KRAP complex at the desmosomes: A new player in the apoptotic process	5
The bitter end: T2R bitter receptor agonists elevate nuclear calcium and induce apoptosis in non-ciliated airway epithelial cells	5
Role of STIM2 and Orai proteins in regulating TRPC1 channel activity upon calcium store depletion	5
TRPC3 governs the spatiotemporal organization of cellular Ca2+ signatures by functional coupling to IP3 receptors	5
Inhibition of TRPV1 by an antagonist in clinical trials is dependent on cholesterol binding	5
The Ca2+ channel TRPV4 is dispensable for Ca2+ influx and cell volume regulation during hypotonic stress response in human keratinocyte cell lines	5
Role of mitochondria in liver metabolic health and diseases	5
Decline of astrocyte Ca2+ signalling in Alzheimer's disease: STIM1 to the rescue!	5
Towards a systems-level understanding of mitochondrial biology	5
Calcium and chloride out of sync: The role of signaling in Sjögren's salivary gland issues	5
Calcium signals as regulators of ferroptosis in cancer	5
KRAP is required for diffuse and punctate IP3-mediated Ca2+ liberation and determines the number of functional IP3R channels within clusters	5
TRPV1: Receptor structure, activation, modulation and role in neuro-immune interactions and pain	5
The calcium signaling enzyme CD38 - a paradigm for membrane topology defining distinct protein functions	5
Sprinkling salt on mitochondria: The metabolic and pathophysiological roles of mitochondrial Na+ signaling mediated by NCLX	4
Shedding light on ORAI1 channel with genetic code expansion	4
Editorial Board	4
The interplay between associated proteins, redox state and Ca2+ in the intraluminal ER compartment regulates the IP3 receptor	4
“Functional communication between IP3R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE”	4

Optical profiling of autonomous Ca2+ nanodomains generated by lysosomal TPC2 and TRPML1	4
Proton-modulated interactions of ions with transport sites of prokaryotic and eukaryotic NCX prototypes	4
Editorial Board	4
Anoctamins in epithelial transport	4
Identification and characterization of the promoter and transcription factors regulating the expression of cerebral sodium/calcium exchanger 2 (NCX2) gene	4
Unravelling the complexity of the mitochondrial Ca2+ uniporter: regulation, tissue specificity, and physiological implications	4
Signaling pathways regulating mitochondrial calcium efflux – a commentary on Rozenfeld et al. “Essential role of the mitochondrial Na+/Ca2+ exchanger NCLX in mediating PDE2-dependent neuronal survival	4
Roles for TRPV4 in disease: A discussion of possible mechanisms	4
Above the legal limit: Alcohol brings ER and mitochondria too close together	4
Pentameric TRPV3: An artifact or a clue to channel function?	4
CRACing the role of calcium signaling in ILC2s	4
Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7	4
Editorial Board	3
TMEM94 cannot be called a P-type ATPase	3
TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?	3
Rheumatoid arthritis: Relief of IKAROS transcriptional repression of Orai3 in T-cells	3
Native SOCE complexes: Small but mighty?	3
Insertion of circularly permuted cyan fluorescent protein into the ligand-binding domain of inositol 1,4,5-trisphosphate receptor for enhanced FRET upon binding of fluorescent ligand	3
RyR-ing up nuclear calcium signaling and CREB-mediated gene expression	3
Catching the next wave of recombinant RyR2 cryo-EM structures. Commentary on “Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations”	3
Specific cytokines of interleukin-6 family interact with S100 proteins	3
Mechanosensitive Piezo1 in endothelial cells promotes angiogenesis to support bone fracture repair	3
Mutation in RyR2-FKBP Binding site alters Ca2+ signaling modestly but increases “arrhythmogenesis” in human stem cells derived cardiomyocytes	3
PEG out through the pores with the help of ESCRTIII	3
Cimifugin relieves pruritus in psoriasis by inhibiting TRPV4	3
CRACR2A associated immunodeficiency – the supporting factor takes center stage	3
Uncovering a new route to pain therapy	3
I scream for ice cream – TRPC5 as cold sensor in teeth	3
Putting the pressure on endocytosis in the kidney	3
Another novel non-conducting functional role for Kv2 channels – regulation of calcium signaling	3
A novel probe to monitor lysosome-mitochondria contact sites opens up a new path to study neurodegenerative diseases	3
Bok joining the “Ca2+ club”	3
The dynamic TRPV2 ion channel proximity proteome reveals functional links of calcium flux with cellular adhesion factors NCAM and L1CAM in neurite outgrowth	3
The A-kinase anchoring protein Yotiao decrease the ER calcium content by inhibiting the store operated calcium entry	3
Calcineurin: A star is reborn	3
What structures did, and did not, reveal about the function of the epithelial Ca2+ channels TRPV5 and TRPV6	3
Calcium and redox signals at mitochondrial interfaces: A nanoview perspective	3
Tuning TPC2	3
Commentary on structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations	3
Ca2+ signaling in postsynaptic neurons: Neuroplastin-65 regulates the interplay between plasma membrane Ca2+ ATPases and ionotropic glutamate receptors	3
Role of auditory-somatosensory corticothalamic circuit integration in analgesia	2
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration	2
Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer	2
Anoctamin 1, a multi-modal player in pain and itch	2
Editorial Board	2
Editorial Board	2
Ca2+ signalling: A common language for organelles crosstalk in Parkinson's disease	2
Mitochondria Associated Membranes (MAMs): Architecture and physiopathological role	2
Corrigendum to “Loss-of-function W4645R mutation in the RyR2-caffeine binding site: implications for synchrony and arrhythmogenesis” [Cell Calcium 123 (2024) 102925]	2
Full-fusion and kiss-and-run in chromaffin cells controlled by irreversible vesicle size-dependent fusion pore transitions	2
Phosphorylation of STIM1 at ERK/CDK sites is dispensable for cell migration and ER partitioning in mitosis	2
TRPM2 - An adjustable thermostat	2
Postnatal maturation of calcium signaling in islets of Langerhans from neonatal mice	2
Homeostatic calcium fluxes, ER calcium release, SOCE, and calcium oscillations in cultured astrocytes are interlinked by a small calcium toolkit	2
NMDA receptor-mediated Ca2+ signaling: Impact on cell cycle regulation and the development of neurodegenerative diseases and cancer	2
CatSper channels in sea urchin sperm	2
Interstitial cell of Cajal-like cells (ICC-LC) exhibit dynamic spontaneous activity but are not functionally innervated in mouse urethra	2
Regulation and role of calcium in cellular senescence	2
PIP2 primes IP3 receptor activity: It takes at least three IP3s to open!	2
In memoriam of Shun-ichi Miyazaki 1941–2024	2
Opening the floodgates: An emerging role for Connexin-43 hemichannels in the heart	2
Endogenous insulin directly protects pancreatic acinar cells in pancreatitis	2
Vesicle cholesterol controls exocytotic fusion pore	2
Mitochondrial dysfunction in neurodegenerative diseases: A focus on iPSC-derived neuronal models	2
Tubular aggregate myopathy mutant unveils novel activation and inactivation mechanisms of Orai1	2
Insights into the molecular basis of the palmitoylation and depalmitoylation of NCX1	2
STIMulating IRE1: How store-operated Ca2+ entry intersects with ER proteostasis	2
Differential expression of the three independent CaM genes coding for an identical protein: Potential relevance of distinct mRNA stability by different codon usage	2
Recent studies on NCLX in health and diseases	2
MICU1 deficiency alters mitochondrial morphology and cytochrome C release	2
An open pore structure of the Orai channel, finally	1
Andrographolide ameliorates aortic valve calcification by regulation of lipid biosynthesis and glycerolipid metabolism targeting MGLL expression in vitro and in vivo	1
Editorial Board	1
Skeletal muscle mitochondria in health and disease	1
Ca2+ transients in ICC-MY define the basis for the dominance of the corpus in gastric pacemaking	1
Minor contribution of NCX to Na+-Ca2+ exchange activity in brain mitochondria	1
The mitochondrial calcium uniporter complex–A play in five acts	1
The expression of constitutively active CPK3 impairs potassium uptake and transport in Arabidopsis under low K+ stress	1
Conjugated polymers mediate intracellular Ca2+ signals in circulating endothelial colony forming cells through the reactive oxygen species-dependent activation of Transient Receptor Potential Vanilloi	1
The ryanodine receptor microdomain in cardiomyocytes	1
Astrocytic chloride regulates brain function in health and disease	1
ZnR/GPR39 controls cell migration by orchestrating recruitment of KCC3 into protrusions, re-organization of actin and activation of MMP	1
Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells	1
Na+/Ca2+ exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons	1
Channelopathy-causing mutations in the S45A/S45B and HA/HB helices of KCa2.3 and KCa3.1 channels alter their apparent Ca2+ sensitivity	1
STIM2: Redox-sensor and effector of the (tumor) microenvironment	1
IP3 receptors: An “elementary” journey from structure to signals	1
The role of Ca2+ signalling in the pathology of exocrine pancreas	1
Calcium as a master regulator of ferroptosis and other types of regulated necrosis	1
Glucose-induced [Ca2+]i oscillations in β cells are composed of trains of spikes within a subplasmalemmal microdomain	1
Differential modulation of SK channel subtypes by phosphorylation	1
Enhanced modulation of cell-type specific neuronal responses in mouse dorsal auditory field during locomotion	1
High resolution cryo-EM structures of TRPC5-Gαi3 complexes reveal direct activation of an ion channel by Gαi-GTP	1
VDAC regulation of mitochondrial calcium flux: From channel biophysics to disease	1
Multi-scale network imaging in a mouse model of amyloidosis	1