Cell Calcium

Article	Citations
Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels	76
Mitochondria Associated Membranes (MAMs): Architecture and physiopathological role	71
Role of mitochondria in liver metabolic health and diseases	63
VDAC regulation of mitochondrial calcium flux: From channel biophysics to disease	54
Ca2+ handling at the mitochondria-ER contact sites in neurodegeneration	54
Liquiritin, a novel inhibitor of TRPV1 and TRPA1, protects against LPS-induced acute lung injury	50
The aging mouse brain: cognition, connectivity and calcium	45
Mitochondrial reactive oxygen species in physiology and disease	42
Piezo1 impairs hepatocellular tumor growth via deregulation of the MAPK-mediated YAP signaling pathway	39
Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel	37
Role of ion channels during cell division	34
Mechanosensitive Piezo1 in endothelial cells promotes angiogenesis to support bone fracture repair	32
IP3 receptor-mediated Ca2+ release from acidocalcisomes regulates mitochondrial bioenergetics and prevents autophagy in Trypanosoma cruzi	31
Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?	31
The molecular complexity of the Mitochondrial Calcium Uniporter	30
Heterogeneous expression of plasma-membrane-localised OsOSCA1.4 complements osmotic sensing based on hyperosmolality and salt stress in Arabidopsis osca1 mutant	29
α-Synuclein emerges as a potent regulator of VDAC-facilitated calcium transport	28
BIRD-2, a BH4-domain-targeting peptide of Bcl-2, provokes Bax/Bak-independent cell death in B-cell cancers through mitochondrial Ca2+-dependent mPTP opening	27
Lysosomal ion channels involved in cellular entry and uncoating of enveloped viruses: Implications for therapeutic strategies against SARS-CoV-2	26
Ca2+ as the prime trigger of aerobic glycolysis in astrocytes	25
Mitochondrial dysfunction in neurodegenerative diseases: A focus on iPSC-derived neuronal models	24
Role of TRPM7 kinase in cancer	24
Targeting mitochondrial calcium pathways as a potential treatment against Parkinson’s disease	24
Calsequestrin. Structure, function, and evolution	22
Two-photon calcium imaging of seizures in awake, head-fixed mice	22

Cimifugin relieves pruritus in psoriasis by inhibiting TRPV4	22
Skeletal muscle mitochondria in health and disease	21
NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain microvascular endothelial cells	21
Orai3: Oncochannel with therapeutic potential	20
SEPT7 regulates Ca2+ entry through Orai channels in human neural progenitor cells and neurons	20
Conjugated polymers mediate intracellular Ca2+ signals in circulating endothelial colony forming cells through the reactive oxygen species-dependent activation of Transient Receptor Potential Vanilloi	20
The role of potassium and host calcium signaling in Toxoplasma gondii egress	20
The calcium signaling enzyme CD38 - a paradigm for membrane topology defining distinct protein functions	19
ANO1 regulates cardiac fibrosis via ATI-mediated MAPK pathway	18
Calcium signaling and epigenetics: A key point to understand carcinogenesis	18
The bitter end: T2R bitter receptor agonists elevate nuclear calcium and induce apoptosis in non-ciliated airway epithelial cells	18
ZnT1 is a neuronal Zn2+/Ca2+ exchanger	17
AHNAK: The quiet giant in calcium homeostasis	17
Andrographolide ameliorates aortic valve calcification by regulation of lipid biosynthesis and glycerolipid metabolism targeting MGLL expression in vitro and in vivo	17
Ca2+ transients in ICC-MY define the basis for the dominance of the corpus in gastric pacemaking	16
Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells	16
Modulating TRPV4 channels with paclitaxel and lithium	16
Control of STIM and Orai function by post-translational modifications	16
Astrocytic mitochondria in adult mouse brain slices show spontaneous calcium influx events with unique properties	16
Insights and perspectives on calcium channel functions in the cockpit of cancerous space invaders	15
Recent studies on NCLX in health and diseases	15
GCaMP as an indirect measure of electrical activity in rat trigeminal ganglion neurons	15
Altered composition of the mitochondrial Ca2+uniporter in the failing human heart	15
Multiple facets of TRPML1 in autophagy	15
Vesicle cholesterol controls exocytotic fusion pore	15
The yin and yang of mitochondrial Ca2+ signaling in cell physiology and pathology	14
TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?	14
Metabolite regulation of the mitochondrial calcium uniporter channel	14
Inhibition of TRPM7 with waixenicin A reduces glioblastoma cellular functions	14
A high throughput machine-learning driven analysis of Ca2+ spatio-temporal maps	14
The great astroglial metabolic revolution: Mitochondria fuel astrocyte homeostatic support and neuroprotection	14
Regulation and role of calcium in cellular senescence	14
Activation of endo-lysosomal two-pore channels by NAADP and PI(3,5)P2. Five things to know.	13
Enhanced modulation of cell-type specific neuronal responses in mouse dorsal auditory field during locomotion	13
NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model	13
PUFAs dictate the balance of power in ferroptosis	13
The mitochondrial permeability transition pore in Ca2+ homeostasis	13
The basics of mitochondrial cAMP signalling: Where, when, why	13
Distinct properties of Ca2+ efflux from brain, heart and liver mitochondria: The effects of Na+, Li+ and the mitochondrial Na+/Ca2+ exchange inhibitor CGP37157	13
PIP2 and septin control STIM1/Orai1 assembly by regulating cytoskeletal remodeling via a CDC42-WASP/WAVE-ARP2/3 protein complex	13
Mitochondria as the decision makers for cancer cell fate: from signaling pathways to therapeutic strategies	13
Attenuation of the extracellular matrix increases the number of synapses but suppresses synaptic plasticity through upregulation of SK channels	13
Cristae junction as a fundamental switchboard for mitochondrial ion signaling and bioenergetics	13
Calcium signaling: A therapeutic target to overcome resistance to therapies in cancer	12
BRAF and NRAS mutated melanoma: Different Ca2+ responses, Na+/Ca2+ exchanger expression, and sensitivity to inhibitors	12
Acidic Ca2+ stores and immune-cell function	12
Mending Fences: Na,K-ATPase signaling via Ca2+ in the maintenance of epithelium integrity	12
Ca2+ signaling of human pluripotent stem cells-derived cardiomyocytes as compared to adult mammalian cardiomyocytes	12
The ER-mitochondria interface, where Ca2+ and cell death meet	12
Insights into the molecular basis of the palmitoylation and depalmitoylation of NCX1	12

A novel role of FKN/CX3CR1 in promoting osteogenic transformation of VSMCs and atherosclerotic calcification	12
Specific cytokines of interleukin-6 family interact with S100 proteins	11
Na+/Ca2+ exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons	11
TRPV4 and TRPC1 channels mediate the response to tensile strain in mouse Müller cells	11
Calcium activates purified human TRPA1 with and without its N-terminal ankyrin repeat domain in the absence of calmodulin	11
Ca2+ signaling and cell death	10
PANX1 in inflammation heats up: New mechanistic insights with implications for injury and infection	10
Insulin-like growth factor-1 regulates the mechanosensitivity of chondrocytes by modulating TRPV4	10
SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer	10
Sprinkling salt on mitochondria: The metabolic and pathophysiological roles of mitochondrial Na+ signaling mediated by NCLX	10
Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7	10
Role of STIM2 and Orai proteins in regulating TRPC1 channel activity upon calcium store depletion	10
Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca2+ stores	9
Differential modulation of SK channel subtypes by phosphorylation	9
Homeostatic calcium fluxes, ER calcium release, SOCE, and calcium oscillations in cultured astrocytes are interlinked by a small calcium toolkit	9
The impact of calmodulin on the cell cycle analyzed in a novel human cellular genetic system	9
TRPV3 endogenously expressed in murine colonic epithelial cells is inhibited by the novel TRPV3 blocker 26E01	9
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39	9
Multi-scale network imaging in a mouse model of amyloidosis	9
Ca2+ signaling in postsynaptic neurons: Neuroplastin-65 regulates the interplay between plasma membrane Ca2+ ATPases and ionotropic glutamate receptors	9
Loss of PKD1 and PKD2 share common effects on intracellular Ca2+ signaling	9
Lysosomal potassium channels	9
The evolution of organellar calcium mapping technologies	9
Synthetic alkyl-ether-lipid promotes TRPV2 channel trafficking trough PI3K/Akt-girdin axis in cancer cells and increases mammary tumour volume	9
In vivo analysis of the spontaneous firing of cerebellar Purkinje cells in awake transgenic mice that model spinocerebellar ataxia type 2	9
Postnatal maturation of calcium signaling in islets of Langerhans from neonatal mice	9
CatSper channels in sea urchin sperm	8
Relevance of lysosomal Ca2+ signalling machinery in cancer	8
The ins and outs of virus trafficking through acidic Ca2+ stores	8
Exploring the Li+ transporting mutant of NCX_Mj for assigning ion binding sites of mitochondrial NCLX	8
Pannexin 1 plays a pro-survival role by attenuating P2X7 receptor-mediated Ca2+ influx	8
Dopamine controls neuronal spontaneous calcium oscillations via astrocytic signal	8
Remodelling of Ca2+ homeostasis is linked to enlarged endoplasmic reticulum in secretory cells	8
TRPC3 governs the spatiotemporal organization of cellular Ca2+ signatures by functional coupling to IP3 receptors	8
LIPID transfer proteins regulate store-operated calcium entry via control of plasma membrane phosphoinositides	8
Glucose-induced [Ca2+]i oscillations in β cells are composed of trains of spikes within a subplasmalemmal microdomain	8
The expression of constitutively active CPK3 impairs potassium uptake and transport in Arabidopsis under low K+ stress	8
KRAP is required for diffuse and punctate IP3-mediated Ca2+ liberation and determines the number of functional IP3R channels within clusters	8
CaMKIV regulates mitochondrial dynamics during sepsis	8
Modulators of TRPM7 and its potential as a drug target for brain tumours	8
The TAM-associated STIM1I484R mutation increases ORAI1 channel function due to a reduced STIM1 inactivation break and an absence of microtubule trapping	8
CaV1.3 enhanced store operated calcium promotes resistance to androgen deprivation in prostate cancer	7
p53 alters intracellular Ca2+ signaling through regulation of TRPM4	7
ZnR/GPR39 controls cell migration by orchestrating recruitment of KCC3 into protrusions, re-organization of actin and activation of MMP	7
Vascular Kv7 channels control intracellular Ca2+ dynamics in smooth muscle	7
Ryanodine receptor-mediated Ca2+ release and atlastin-2 GTPase activity contribute to IP3-induced dendritic Ca2+ signals in primary hippocampal neurons	7
Targeted Gq-GPCR activation drives ER-dependent calcium oscillations in chondrocytes	7
JPT2: The missing link between intracellular Ca2+ release channels and NAADP?	7
Channelopathy-causing mutations in the S45A/S45B and HA/HB helices of KCa2.3 and KCa3.1 channels alter their apparent Ca2+ sensitivity	7
Full-fusion and kiss-and-run in chromaffin cells controlled by irreversible vesicle size-dependent fusion pore transitions	7
Understanding IP3R channels: From structural underpinnings to ligand-dependent conformational landscape	7
Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts	7
VDAC2 as a novel target for heart failure: Ca2+ at the sarcomere, mitochondria and SR	7
Human platelets use a cytosolic Ca2+ nanodomain to activate Ca2+-dependent shape change independently of platelet aggregation	7
Differential expression of the three independent CaM genes coding for an identical protein: Potential relevance of distinct mRNA stability by different codon usage	7
TRPC1 channels regulate the activation of pancreatic stellate cells through ERK1/2 and SMAD2 pathways and perpetuate their pressure-mediated activation	7
Potential of targeting host cell calcium dynamics to curtail SARS-CoV-2 infection and COVID-19 pathogenesis	7
Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer	6
Lactate as a new second messenger shaping intracellular Mg2+ dynamics and bioenergetics	6
Regulation of the tubulin polymerization-promoting protein by Ca2+/S100 proteins	6
Isoproterenol-induced hypertrophy of neonatal cardiac myocytes and H9c2 cell is dependent on TRPC3-regulated CaV1.2 expression	6
Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures	6
Mannan-binding lectin deficiency augments hepatic endoplasmic reticulum stress through IP3R-controlled calcium release	6
Gating and calcium-sensing mechanisms of TRPA1 channels revealed	6
Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells	6
Ca2+ signaling and lipid transfer ‘pas a deux’ at ER-PM contact sites orchestrate cell migration	6
Ca2+ signalling system initiated by endoplasmic reticulum stress stimulates PERK activation	6
Insulin-induced palmitoylation regulates the Cardiac Na+/Ca2+ exchanger NCX1	6
Toll-like receptor 4 activation enhances Orai1-mediated calcium signal promoting cytokine production in spinal astrocytes.	6
Structural biology of cation channels important for lysosomal calcium release	6
Spontaneous and action potential-evoked Ca2+ release from endoplasmic reticulum in neocortical synaptic boutons	6
Calcium signaling in polycystic kidney disease- cell death and survival	6
A TRPV6 expression atlas for the mouse	6
Coordinated glucose-induced Ca2+ and pH responses in yeast Saccharomyces cerevisiae	6
Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7	6
Regulation of the Ca2+-activated chloride channel Anoctamin-1 (TMEM16A) by Ca2+-induced interaction with FKBP12 and calcineurin	6
Characterization of cell type-specific S100B expression in the mouse olfactory bulb	6
RyR2 calcium channels in the spotlight—I’m ready for my close up, Dr. Alzheimer!	6
Diversity of two-pore channels and the accessory NAADP receptors in intracellular Ca2+ signaling	6
The unfolding and activation of STIM1 in store-operated calcium signal generation	6

The mitochondrial sodium/calcium exchanger NCLX (Slc8b1) in B lymphocytes	6
Gating of the capsaicin receptor TRPV1 by UVA-light and oxidants are mediated by distinct mechanisms	5
PI(3,5)P2 and NAADP: Team players or lone warriors? – New insights into TPC activation modes	5
The dynamic nature of exocytosis from large secretory vesicles. A view from electrochemistry and imaging	5
Calcium as a master regulator of ferroptosis and other types of regulated necrosis	5
Autonomous activation of CaMKII exacerbates diastolic calcium leak during beta-adrenergic stimulation in cardiomyocytes of metabolic syndrome rats	5
Enhanced Ca2+ handling in thioglycolate-elicited peritoneal macrophages	5
Analysis of neuronal Ca2+ handling properties by combining perforated patch clamp recordings and the added buffer approach	5
T lymphocytes from malignant hyperthermia-susceptible mice display aberrations in intracellular calcium signaling and mitochondrial function	5
Mechanosensitive Piezo1 channel in rat epididymal epithelial cells promotes transepithelial K+ secretion	5
Neuron-derived factors negatively modulate ryanodine receptor-mediated calcium release in cultured mouse astrocytes	5
Divalent cations permeation in a Ca2+ non-conducting skeletal muscle dihydropyridine receptor mouse model	5
Calcium signaling in lysosome-dependent cell death	5
Mutation in RyR2-FKBP Binding site alters Ca2+ signaling modestly but increases “arrhythmogenesis” in human stem cells derived cardiomyocytes	5
The Mitochondrial Ca2+ import complex is altered in ADPKD	5
Interplay between calcium and endoplasmic reticulum stress	5
Ca2+-dependent binding of S100A6 to cofilin-1 regulates actin filament polymerization-depolymerization dynamics	5
Inositol polyphosphate multikinase IPMK-1 regulates development through IP3/calcium signaling in Caenorhabditis elegans	5
Uncorking MCU to let the calcium flow	5
The mitochondrial calcium uniporter complex–A play in five acts	5
Parenchymal pressure injury Ca2+ entry mechanism in pancreatitis	5
Blockage of transient receptor potential vanilloid 4 prevents postoperative atrial fibrillation by inhibiting NLRP3-inflammasome in sterile pericarditis mice	5
Roles of cADPR and NAADP in pancreatic beta cell signaling	5
Is CD38 involved in Ca2+ signalling elicited by activation of T cell receptors?	5
To B, or not to B: Is calcium the answer?	5
TRPC4 ion channel regulations by small-molecular inhibitors and calmodulin	4
A greasy business: Identification of a diacylglycerol binding site in human TRPC5 channels by cryo-EM	4
Bcl-xL and IP3R interaction: Intimate relationship with an uncertain outcome	4
Stable behavioral state-specific large scale activity patterns in the developing cortex of neonates	4
IP3 receptors: An “elementary” journey from structure to signals	4
Role of auditory-somatosensory corticothalamic circuit integration in analgesia	4
CaV2.2 (N-type) voltage-gated calcium channels are activated by SUMOylation pathways	4
Too much of a good thing: The case of SOCE in cellular apoptosis	4
Injury-induced Erk1/2 signaling tissue-specifically interacts with Ca2+ activity and is necessary for regeneration of spinal cord and skeletal muscle	4
High-throughput assessment identifying major platelet Ca2+ entry pathways via tyrosine kinase-linked and G protein-coupled receptors	4
IN BRAIN POST-ISCHEMIC PLASTICITY, Na+/Ca2+ EXCHANGER 1 AND Ascl1 INTERVENE IN MICROGLIA-DEPENDENT CONVERSION OF ASTROCYTES INTO NEURONAL LINEAGE	4
Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer	4
The role of Ca2+ signalling in the pathology of exocrine pancreas	4
PEG out through the pores with the help of ESCRTIII	4
What structures did, and did not, reveal about the function of the epithelial Ca2+ channels TRPV5 and TRPV6	4
Presynaptic-like mechanisms and the control of insulin secretion in pancreatic β-cells.	4
EPIC3, a novel Ca2+ indicator located at the cell cortex and in microridges, detects high Ca2+ subdomains during Ca2+ influx and phagocytosis	4
Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells	4
STIM1 is the key that unlocks airway smooth muscle remodeling and hyperresponsiveness during asthma	4
The STIM1 Phosphorylation Saga	4
Termination of Ca2+ puffs during IP3-evoked global Ca2+ signals	4
Cell calcium	4
Phosphorylation of STIM1 at ERK/CDK sites is dispensable for cell migration and ER partitioning in mitosis	4
Dual function of the choroid plexus: Cerebrospinal fluid production and control of brain ion homeostasis	4
In the right place at the right time: ROS and Ca2+ are allies in the battle for survival	4
Cytosolic Ca2+ oversees the MASs production of pyruvate for the mitochondrial market	4
Into the spotlight: RGK proteins in skeletal muscle	3
Calcium signaling and genetic rare diseases: An auditory perspective	3
Mitochondrial Ca2+ signaling and Alzheimer's disease: Too much or too little?	3
Why endogenous TRPV6 currents are not detectable-what can we learn from bats?	3
The name tells the story: Two-pore channels	3
Ca2+ signalling: A common language for organelles crosstalk in Parkinson's disease	3
A STIMulating journey into optogenetic engineering	3
Pentameric TRPV3: An artifact or a clue to channel function?	3
Opening the floodgates: An emerging role for Connexin-43 hemichannels in the heart	3
Presenilin 1 is a direct regulator of the cardiac sarco/endoplasmic reticulum calcium pump	3
Dynamin 1 controls vesicle size and endocytosis at hippocampal synapses	3
NAADP receptors: A one-two.	3
Stay or go? Neuronal activity in medial frontal cortex during a voluntary tactile preference task in head-fixed mice	3
Where have all the Orais gone? Commentary on “Orai1 channels are essential for amplification of glutamate-evoked Ca2+ signals in dendritic spines to regulate working and associative memory”	3
Astrocytes regulate action potential propagation in myelinated axons: It is very crowded at the node of Ranvier	3
Minor contribution of NCX to Na+-Ca2+ exchange activity in brain mitochondria	3
Endolysosomal calcium release and cardiac physiology	3
STIM2: Redox-sensor and effector of the (tumor) microenvironment	3
Oxytocin prevents neuronal network pain-related changes on spinal cord dorsal horn in vitro	3
PunctaSpecks: A tool for automated detection, tracking, and analysis of multiple types of fluorescently labeled biomolecules	3
Calcium signalling in hepatic metabolism: Health and diseases	3
Handling a mature calcium signature through optogenetics improves the differentiation of primary murine myotubes	3
Pivotal role of the ORAI3-STIM2 complex in the control of mitotic death and prostate cancer cell cycle progression	3
The role of Ca2+-signaling in the regulation of epigenetic mechanisms	3
New insights into gating mechanisms in TPCs: Relevance for drug discovery	3
Calcium signaling in chemotherapy-induced neuropathy	3
Modulation of carbachol-induced Ca2+ oscillations in airway smooth muscle cells by PGE2	3
Sodium homeostasis and signalling: The core and the hub of astrocyte function	3
Unconventional role of lysosomes in phagocytosis	3
The Ca2+ channel TRPV4 is dispensable for Ca2+ influx and cell volume regulation during hypotonic stress response in human keratinocyte cell lines	3
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration	3
Characterization of a functional Ca2+ toolkit in urine-derived stem cells and derived skeletal muscle cells	3
T-type channels in cancer cells: Driving in reverse	3