Cell Calcium

Article	Citations
Mitochondria Associated Membranes (MAMs): Architecture and physiopathological role	80
Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels	77
Role of mitochondria in liver metabolic health and diseases	69
VDAC regulation of mitochondrial calcium flux: From channel biophysics to disease	62
Ca2+ handling at the mitochondria-ER contact sites in neurodegeneration	58
The aging mouse brain: cognition, connectivity and calcium	51
Piezo1 impairs hepatocellular tumor growth via deregulation of the MAPK-mediated YAP signaling pathway	47
Mitochondrial reactive oxygen species in physiology and disease	46
Mechanosensitive Piezo1 in endothelial cells promotes angiogenesis to support bone fracture repair	39
Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel	39
Role of ion channels during cell division	37
Heterogeneous expression of plasma-membrane-localised OsOSCA1.4 complements osmotic sensing based on hyperosmolality and salt stress in Arabidopsis osca1 mutant	32
The molecular complexity of the Mitochondrial Calcium Uniporter	32
α-Synuclein emerges as a potent regulator of VDAC-facilitated calcium transport	31
IP3 receptor-mediated Ca2+ release from acidocalcisomes regulates mitochondrial bioenergetics and prevents autophagy in Trypanosoma cruzi	31
Ca2+ as the prime trigger of aerobic glycolysis in astrocytes	28
BIRD-2, a BH4-domain-targeting peptide of Bcl-2, provokes Bax/Bak-independent cell death in B-cell cancers through mitochondrial Ca2+-dependent mPTP opening	27
Lysosomal ion channels involved in cellular entry and uncoating of enveloped viruses: Implications for therapeutic strategies against SARS-CoV-2	26
Mitochondrial dysfunction in neurodegenerative diseases: A focus on iPSC-derived neuronal models	26
Cimifugin relieves pruritus in psoriasis by inhibiting TRPV4	26
Role of TRPM7 kinase in cancer	25
NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain microvascular endothelial cells	24
Two-photon calcium imaging of seizures in awake, head-fixed mice	24
The role of potassium and host calcium signaling in Toxoplasma gondii egress	23
Skeletal muscle mitochondria in health and disease	22

Conjugated polymers mediate intracellular Ca2+ signals in circulating endothelial colony forming cells through the reactive oxygen species-dependent activation of Transient Receptor Potential Vanilloi	21
Regulation and role of calcium in cellular senescence	21
Altered composition of the mitochondrial Ca2+uniporter in the failing human heart	20
The calcium signaling enzyme CD38 - a paradigm for membrane topology defining distinct protein functions	20
ANO1 regulates cardiac fibrosis via ATI-mediated MAPK pathway	20
Control of STIM and Orai function by post-translational modifications	19
ZnT1 is a neuronal Zn2+/Ca2+ exchanger	19
Calcium signaling and epigenetics: A key point to understand carcinogenesis	19
The ER-mitochondria interface, where Ca2+ and cell death meet	19
The bitter end: T2R bitter receptor agonists elevate nuclear calcium and induce apoptosis in non-ciliated airway epithelial cells	19
Ca2+ signaling and cell death	18
Andrographolide ameliorates aortic valve calcification by regulation of lipid biosynthesis and glycerolipid metabolism targeting MGLL expression in vitro and in vivo	18
The mitochondrial permeability transition pore in Ca2+ homeostasis	18
Recent studies on NCLX in health and diseases	18
AHNAK: The quiet giant in calcium homeostasis	18
Ca2+ transients in ICC-MY define the basis for the dominance of the corpus in gastric pacemaking	18
PUFAs dictate the balance of power in ferroptosis	17
Modulating TRPV4 channels with paclitaxel and lithium	17
Vesicle cholesterol controls exocytotic fusion pore	17
TRPV4 and TRPC1 channels mediate the response to tensile strain in mouse Müller cells	17
Astrocytic mitochondria in adult mouse brain slices show spontaneous calcium influx events with unique properties	17
TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?	16
Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells	16
Metabolite regulation of the mitochondrial calcium uniporter channel	15
Activation of endo-lysosomal two-pore channels by NAADP and PI(3,5)P2. Five things to know.	15
Distinct properties of Ca2+ efflux from brain, heart and liver mitochondria: The effects of Na+, Li+ and the mitochondrial Na+/Ca2+ exchange inhibitor CGP37157	15
PIP2 and septin control STIM1/Orai1 assembly by regulating cytoskeletal remodeling via a CDC42-WASP/WAVE-ARP2/3 protein complex	15
Calcium signaling: A therapeutic target to overcome resistance to therapies in cancer	15
Enhanced modulation of cell-type specific neuronal responses in mouse dorsal auditory field during locomotion	15
The great astroglial metabolic revolution: Mitochondria fuel astrocyte homeostatic support and neuroprotection	15
The yin and yang of mitochondrial Ca2+ signaling in cell physiology and pathology	15
Role of STIM2 and Orai proteins in regulating TRPC1 channel activity upon calcium store depletion	15
Inhibition of TRPM7 with waixenicin A reduces glioblastoma cellular functions	14
A high throughput machine-learning driven analysis of Ca2+ spatio-temporal maps	14
A novel role of FKN/CX3CR1 in promoting osteogenic transformation of VSMCs and atherosclerotic calcification	14
Insights into the molecular basis of the palmitoylation and depalmitoylation of NCX1	13
Attenuation of the extracellular matrix increases the number of synapses but suppresses synaptic plasticity through upregulation of SK channels	13
The basics of mitochondrial cAMP signalling: Where, when, why	13
Cristae junction as a fundamental switchboard for mitochondrial ion signaling and bioenergetics	13
Mitochondria as the decision makers for cancer cell fate: from signaling pathways to therapeutic strategies	13
NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model	13
Acidic Ca2+ stores and immune-cell function	13
The evolution of organellar calcium mapping technologies	12
Homeostatic calcium fluxes, ER calcium release, SOCE, and calcium oscillations in cultured astrocytes are interlinked by a small calcium toolkit	12
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39	12
Specific cytokines of interleukin-6 family interact with S100 proteins	12
Na+/Ca2+ exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons	12
SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer	11
Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7	11
Structural biology of cation channels important for lysosomal calcium release	11

Lysosomal potassium channels	11
Differential modulation of SK channel subtypes by phosphorylation	10
Sprinkling salt on mitochondria: The metabolic and pathophysiological roles of mitochondrial Na+ signaling mediated by NCLX	10
Potential of targeting host cell calcium dynamics to curtail SARS-CoV-2 infection and COVID-19 pathogenesis	10
Calcium signaling in lysosome-dependent cell death	10
Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7	10
Insulin-like growth factor-1 regulates the mechanosensitivity of chondrocytes by modulating TRPV4	10
Ca2+ signaling in postsynaptic neurons: Neuroplastin-65 regulates the interplay between plasma membrane Ca2+ ATPases and ionotropic glutamate receptors	10
Understanding IP3R channels: From structural underpinnings to ligand-dependent conformational landscape	10
Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca2+ stores	9
TRPC3 governs the spatiotemporal organization of cellular Ca2+ signatures by functional coupling to IP3 receptors	9
Synthetic alkyl-ether-lipid promotes TRPV2 channel trafficking trough PI3K/Akt-girdin axis in cancer cells and increases mammary tumour volume	9
The expression of constitutively active CPK3 impairs potassium uptake and transport in Arabidopsis under low K+ stress	9
KRAP is required for diffuse and punctate IP3-mediated Ca2+ liberation and determines the number of functional IP3R channels within clusters	9
Loss of PKD1 and PKD2 share common effects on intracellular Ca2+ signaling	9
Pannexin 1 plays a pro-survival role by attenuating P2X7 receptor-mediated Ca2+ influx	9
Modulators of TRPM7 and its potential as a drug target for brain tumours	9
Multi-scale network imaging in a mouse model of amyloidosis	9
In vivo analysis of the spontaneous firing of cerebellar Purkinje cells in awake transgenic mice that model spinocerebellar ataxia type 2	9
TRPV1: Receptor structure, activation, modulation and role in neuro-immune interactions and pain	9
TRPV3 endogenously expressed in murine colonic epithelial cells is inhibited by the novel TRPV3 blocker 26E01	9
TRPC1 channels regulate the activation of pancreatic stellate cells through ERK1/2 and SMAD2 pathways and perpetuate their pressure-mediated activation	9
Differential expression of the three independent CaM genes coding for an identical protein: Potential relevance of distinct mRNA stability by different codon usage	9
Exploring the Li+ transporting mutant of NCX_Mj for assigning ion binding sites of mitochondrial NCLX	9
CatSper channels in sea urchin sperm	9
Postnatal maturation of calcium signaling in islets of Langerhans from neonatal mice	9
CaMKIV regulates mitochondrial dynamics during sepsis	9
Spontaneous and action potential-evoked Ca2+ release from endoplasmic reticulum in neocortical synaptic boutons	8
Remodelling of Ca2+ homeostasis is linked to enlarged endoplasmic reticulum in secretory cells	8
The dynamic nature of exocytosis from large secretory vesicles. A view from electrochemistry and imaging	8
Vascular Kv7 channels control intracellular Ca2+ dynamics in smooth muscle	8
Relevance of lysosomal Ca2+ signalling machinery in cancer	8
LIPID transfer proteins regulate store-operated calcium entry via control of plasma membrane phosphoinositides	8
VDAC2 as a novel target for heart failure: Ca2+ at the sarcomere, mitochondria and SR	8
Glucose-induced [Ca2+]i oscillations in β cells are composed of trains of spikes within a subplasmalemmal microdomain	8
Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer	8
Ryanodine receptor-mediated Ca2+ release and atlastin-2 GTPase activity contribute to IP3-induced dendritic Ca2+ signals in primary hippocampal neurons	8
Too much of a good thing: The case of SOCE in cellular apoptosis	8
Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts	8
Calcium signaling in polycystic kidney disease- cell death and survival	8
The TAM-associated STIM1I484R mutation increases ORAI1 channel function due to a reduced STIM1 inactivation break and an absence of microtubule trapping	8
Full-fusion and kiss-and-run in chromaffin cells controlled by irreversible vesicle size-dependent fusion pore transitions	8
The ins and outs of virus trafficking through acidic Ca2+ stores	8
Isoproterenol-induced hypertrophy of neonatal cardiac myocytes and H9c2 cell is dependent on TRPC3-regulated CaV1.2 expression	8
JPT2: The missing link between intracellular Ca2+ release channels and NAADP?	7
Channelopathy-causing mutations in the S45A/S45B and HA/HB helices of KCa2.3 and KCa3.1 channels alter their apparent Ca2+ sensitivity	7
Calcium as a master regulator of ferroptosis and other types of regulated necrosis	7
Ca2+ signalling system initiated by endoplasmic reticulum stress stimulates PERK activation	7
Injury-induced Erk1/2 signaling tissue-specifically interacts with Ca2+ activity and is necessary for regeneration of spinal cord and skeletal muscle	7
CaV1.3 enhanced store operated calcium promotes resistance to androgen deprivation in prostate cancer	7
Mannan-binding lectin deficiency augments hepatic endoplasmic reticulum stress through IP3R-controlled calcium release	7
Dopamine controls neuronal spontaneous calcium oscillations via astrocytic signal	7
ZnR/GPR39 controls cell migration by orchestrating recruitment of KCC3 into protrusions, re-organization of actin and activation of MMP	7
Role of auditory-somatosensory corticothalamic circuit integration in analgesia	7
Dual function of the choroid plexus: Cerebrospinal fluid production and control of brain ion homeostasis	7
Toll-like receptor 4 activation enhances Orai1-mediated calcium signal promoting cytokine production in spinal astrocytes.	7
Targeted Gq-GPCR activation drives ER-dependent calcium oscillations in chondrocytes	7
p53 alters intracellular Ca2+ signaling through regulation of TRPM4	7
The unfolding and activation of STIM1 in store-operated calcium signal generation	7
The mitochondrial sodium/calcium exchanger NCLX (Slc8b1) in B lymphocytes	7
The role of Ca2+ signalling in the pathology of exocrine pancreas	7
Regulation of the tubulin polymerization-promoting protein by Ca2+/S100 proteins	7
Interplay between calcium and endoplasmic reticulum stress	7
High-throughput assessment identifying major platelet Ca2+ entry pathways via tyrosine kinase-linked and G protein-coupled receptors	7
A TRPV6 expression atlas for the mouse	7
Diversity of two-pore channels and the accessory NAADP receptors in intracellular Ca2+ signaling	6
Neuron-derived factors negatively modulate ryanodine receptor-mediated calcium release in cultured mouse astrocytes	6
Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer	6
Sodium homeostasis and signalling: The core and the hub of astrocyte function	6
CaV2.2 (N-type) voltage-gated calcium channels are activated by SUMOylation pathways	6
T lymphocytes from malignant hyperthermia-susceptible mice display aberrations in intracellular calcium signaling and mitochondrial function	6
Insulin-induced palmitoylation regulates the Cardiac Na+/Ca2+ exchanger NCX1	6
RyR2 calcium channels in the spotlight—I’m ready for my close up, Dr. Alzheimer!	6
A greasy business: Identification of a diacylglycerol binding site in human TRPC5 channels by cryo-EM	6
Coordinated glucose-induced Ca2+ and pH responses in yeast Saccharomyces cerevisiae	6
Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells	6
Lactate as a new second messenger shaping intracellular Mg2+ dynamics and bioenergetics	6
T-type channels in cancer cells: Driving in reverse	6
Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures	6
Inositol polyphosphate multikinase IPMK-1 regulates development through IP3/calcium signaling in Caenorhabditis elegans	6

Gating and calcium-sensing mechanisms of TRPA1 channels revealed	6
The mitochondrial calcium uniporter complex–A play in five acts	6
Mutation in RyR2-FKBP Binding site alters Ca2+ signaling modestly but increases “arrhythmogenesis” in human stem cells derived cardiomyocytes	6
Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells	6
Characterization of cell type-specific S100B expression in the mouse olfactory bulb	6
Blockage of transient receptor potential vanilloid 4 prevents postoperative atrial fibrillation by inhibiting NLRP3-inflammasome in sterile pericarditis mice	5
Is CD38 involved in Ca2+ signalling elicited by activation of T cell receptors?	5
TRPC4 ion channel regulations by small-molecular inhibitors and calmodulin	5
Mechanosensitive Piezo1 channel in rat epididymal epithelial cells promotes transepithelial K+ secretion	5
The STIM1 Phosphorylation Saga	5
Uncorking MCU to let the calcium flow	5
Cell calcium	5
The Mitochondrial Ca2+ import complex is altered in ADPKD	5
Enhanced Ca2+ handling in thioglycolate-elicited peritoneal macrophages	5
Handling a mature calcium signature through optogenetics improves the differentiation of primary murine myotubes	5
STIM1 is the key that unlocks airway smooth muscle remodeling and hyperresponsiveness during asthma	5
Ca2+-dependent binding of S100A6 to cofilin-1 regulates actin filament polymerization-depolymerization dynamics	5
Gating of the capsaicin receptor TRPV1 by UVA-light and oxidants are mediated by distinct mechanisms	5
Divalent cations permeation in a Ca2+ non-conducting skeletal muscle dihydropyridine receptor mouse model	5
Roles of cADPR and NAADP in pancreatic beta cell signaling	5
Analysis of neuronal Ca2+ handling properties by combining perforated patch clamp recordings and the added buffer approach	5
Calcium signaling and genetic rare diseases: An auditory perspective	5
The role of Ca2+-signaling in the regulation of epigenetic mechanisms	5
PI(3,5)P2 and NAADP: Team players or lone warriors? – New insights into TPC activation modes	5
IP3 receptors: An “elementary” journey from structure to signals	5
Autonomous activation of CaMKII exacerbates diastolic calcium leak during beta-adrenergic stimulation in cardiomyocytes of metabolic syndrome rats	5
PEG out through the pores with the help of ESCRTIII	4
Pivotal role of the ORAI3-STIM2 complex in the control of mitotic death and prostate cancer cell cycle progression	4
Dynamin 1 controls vesicle size and endocytosis at hippocampal synapses	4
STIM2 variants regulate Orai1/TRPC1/TRPC4-mediated store-operated Ca2+ entry and mitochondrial Ca2+ homeostasis in cardiomyocytes	4
Calcium signaling in chemotherapy-induced neuropathy	4
Termination of Ca2+ puffs during IP3-evoked global Ca2+ signals	4
Opening the floodgates: An emerging role for Connexin-43 hemichannels in the heart	4
What structures did, and did not, reveal about the function of the epithelial Ca2+ channels TRPV5 and TRPV6	4
In the right place at the right time: ROS and Ca2+ are allies in the battle for survival	4
EPIC3, a novel Ca2+ indicator located at the cell cortex and in microridges, detects high Ca2+ subdomains during Ca2+ influx and phagocytosis	4
New insights into gating mechanisms in TPCs: Relevance for drug discovery	4
IN BRAIN POST-ISCHEMIC PLASTICITY, Na+/Ca2+ EXCHANGER 1 AND Ascl1 INTERVENE IN MICROGLIA-DEPENDENT CONVERSION OF ASTROCYTES INTO NEURONAL LINEAGE	4
Stable behavioral state-specific large scale activity patterns in the developing cortex of neonates	4
Phosphorylation of STIM1 at ERK/CDK sites is dispensable for cell migration and ER partitioning in mitosis	4
Calcium signalling in hepatic metabolism: Health and diseases	4
Presynaptic-like mechanisms and the control of insulin secretion in pancreatic β-cells.	4
Where have all the Orais gone? Commentary on “Orai1 channels are essential for amplification of glutamate-evoked Ca2+ signals in dendritic spines to regulate working and associative memory”	4
Bcl-xL and IP3R interaction: Intimate relationship with an uncertain outcome	4
The Ca2+ channel TRPV4 is dispensable for Ca2+ influx and cell volume regulation during hypotonic stress response in human keratinocyte cell lines	4
Minor contribution of NCX to Na+-Ca2+ exchange activity in brain mitochondria	3
Endolysosomal calcium release and cardiac physiology	3
MICU1 deficiency alters mitochondrial morphology and cytochrome C release	3
Optical profiling of autonomous Ca2+ nanodomains generated by lysosomal TPC2 and TRPML1	3
Towards a systems-level understanding of mitochondrial biology	3
Presenilin 1 is a direct regulator of the cardiac sarco/endoplasmic reticulum calcium pump	3
NAADP receptors: A one-two.	3
Is Zn2+ the new Ca2+ for TRPC6 channels in the myocardium?	3
Mitochondrial Ca2+ signaling and Alzheimer's disease: Too much or too little?	3
Astrocytes regulate action potential propagation in myelinated axons: It is very crowded at the node of Ranvier	3
STIM2: Redox-sensor and effector of the (tumor) microenvironment	3
Ca2+ signalling: A common language for organelles crosstalk in Parkinson's disease	3
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration	3
p85α regulatory subunit isoform controls PI3-kinase and TRPC6 membrane translocation	3
How do MICUs gate the mitochondrial calcium uniporter?	3
Structural and functional conservation of the activating Ca2+ binding site in inositol 1,4.5-trisphosphate and ryanodine receptors	3
Into the spotlight: RGK proteins in skeletal muscle	3
Stay or go? Neuronal activity in medial frontal cortex during a voluntary tactile preference task in head-fixed mice	3
Why endogenous TRPV6 currents are not detectable-what can we learn from bats?	3
Trace metals and astrocytes physiology and pathophysiology	3
Autism associated mutations in β2 subunit of voltage-gated calcium channels constitutively activate gene expression	3
Unconventional role of lysosomes in phagocytosis	3
Pentameric TRPV3: An artifact or a clue to channel function?	3
Orai1 is in neurons: Reply to “where have all the Orais gone?”	3
Characterization of a functional Ca2+ toolkit in urine-derived stem cells and derived skeletal muscle cells	3
The physiological roles of anoctamin2/TMEM16B and anoctamin1/TMEM16A in chemical senses	3
Store-operated ion channels: A growing family ?	3
A novel gain of function mutation in TPC2 reiterates pH-pigmentation interplay: Emerging role of ionic homeostasis as a master pigmentation regulator	3
Human IP3 receptor triple knockout stem cells remain pluripotent despite altered mitochondrial metabolism	3
Modulation of carbachol-induced Ca2+ oscillations in airway smooth muscle cells by PGE2	3
High resolution cryo-EM structures of TRPC5-Gαi3 complexes reveal direct activation of an ion channel by Gαi-GTP	2
Preventing a shock to the system. Two-pore channel 1 negatively regulates anaphylaxis	2
Twisting gating residues in the Orai pore	2
IP3-dependent Ca2+ signals are tightly controlled by Cavβ3, but not by Cavβ1, 2 and 4	2
Heterogeneity of the endoplasmic reticulum Ca2+ store determines colocalization with mitochondria	2
Development of chemical tools based on GSK-7975A to study store-operated calcium entry in cells	2
A KRAP(y) job: Defining the localization of active IP3R	2
Astrocytic chloride regulates brain function in health and disease	2
The tether function of the anoctamins	2
Identification and characterization of the promoter and transcription factors regulating the expression of cerebral sodium/calcium exchanger 2 (NCX2) gene	2
Decline of astrocyte Ca2+ signalling in Alzheimer's disease: STIM1 to the rescue!	2
When day meets night: Subsiding calcium signalling translates daylight into new neurones	2
Calcium signal modulation in breast cancer aggressiveness	2
Probing single molecule mechanical interactions of syntaxin 1A with native synaptobrevin 2 residing on a secretory vesicle	2
Ca2+ transport via TRPV6 is regulated by rapid internalization of the channel	2
Calcineurin: A star is reborn	2
Proton-modulated interactions of ions with transport sites of prokaryotic and eukaryotic NCX prototypes	2
Orai1/STIMs modulators in pulmonary vascular diseases	2
Mitochondria-ER contacts and glucose: the powerhouse of Alzheimer's disease?	2
The sigma 1 receptor: A local media influencer	2