Cell Calcium

Article	Citations
Regulating calcium flux through AMPA glutamate receptors	71
Commentary on: Li et al.; Ca2+ transients on the T cell surface trigger rapid integrin activation in a timescale of seconds. Nature Communications (2024)	63
Arriving at the next level of complexity in IP3R and SOCE signaling	58
Store-operated ion channels: A growing family ?	55
Protein diversity in store-operated calcium entry components and their related variants	50
TRPM7 in neurodevelopment and therapeutic prospects for neurodegenerative disease	48
ER calcium stores contribute to glucose-induced Ca2+ waves and intercellular connectivity in mouse pancreatic islets	37
Rapid quantification of intracellular calcium stores reveals effects of membrane micropeptides on SERCA function	36
Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using an In vitro Platform for Improving Insulin Therapy	36
Editorial Board	34
Calcium signals as regulators of ferroptosis in cancer	31
A role for lysosomal calcium channels in mitigating mitochondrial damage and oxidative stress	30
The IP3 receptor-KRAP complex at the desmosomes: A new player in the apoptotic process	29
Abnormal calcium activity and CREB phosphorylation are associated with motor memory impairment in presenilin-1 mutant knock-in mice	29
STIM1: A new player in nuclear dynamics? Lessons learnt from tubular aggregate myopathy	28
MICU1 and MICU2, two peas in a pod or entirely different fruits?	27
Dyclonine inhibition of TRPV3: From functional discovery to structural insight	26
Characterization of a functional Ca2+ toolkit in urine-derived stem cells and derived skeletal muscle cells	25
TRPC3 governs the spatiotemporal organization of cellular Ca2+ signatures by functional coupling to IP3 receptors	23
Catching the next wave of recombinant RyR2 cryo-EM structures. Commentary on “Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations”	23
Macrophage migration inhibitory factor induces phospholamban phosphorylation in cardiac muscle	23
PIP2 primes IP3 receptor activity: It takes at least three IP3s to open!	22
Histamine 1 receptors and reverse-mode Na+/Ca2+ exchanger drive extracellular Na+-dependent intracellular Ca2+ oscillations in human cerebrovascular endothelial cells	22
Role of auditory-somatosensory corticothalamic circuit integration in analgesia	21
Editorial Board	21

Neuronal regulation of myenteric interstitial cells of Cajal (ICC-MY) in the proximal colon	21
Editorial Board	20
Optical profiling of autonomous Ca2+ nanodomains generated by lysosomal TPC2 and TRPML1	20
Ca2+/calmodulin-driven functions mediated by extracellular vesicles: a physiopathological perspective	20
STIMulating IRE1: How store-operated Ca2+ entry intersects with ER proteostasis	20
Editorial Board	20
NAADP-mediated calcium release promotes angiopoietin 2 secretion by regulating Rab46-dependent Weibel-Palade body trafficking	20
Editorial Board	19
Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells	19
High resolution cryo-EM structures of TRPC5-Gαi3 complexes reveal direct activation of an ion channel by Gαi-GTP	19
Editorial Board	18
The role of SERCA in vascular diseases, a potential therapeutic target	18
The tether function of the anoctamins	18
TRPV1 signaling in skeletal muscle: A mini review of physiological and pathological roles	18
IP3 receptors: An “elementary” journey from structure to signals	17
The PHATE of basal epidermal cells: Calcium signaling during the cell cycle	17
Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer	17
Editorial Board	17
Endolysosomal calcium release and cardiac physiology	17
Transcriptional, biochemical, and immunohistochemical analyses of CaMKKβ/2 splice variants that co-localize with CaMKIV in spermatids	16
Endoplasmic reticulum-mitochondria lockdown in Wolfram syndrome	15
GPCR signalling: Yet another variant route in a highly complex road map	15
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39	14
Editorial Board	14
Simultaneous TIRF imaging of subplasmalemmal Ca2+ dynamics and granule fusions in insulin-secreting INS-1 cells reveals coexistent synchronized and asynchronous release	14
Editorial Board	14
The emerging role of TRPV4 in skeletal biology: Mechanotransduction, mutation, and therapeutic potential	14
Editorial Board	13
Editorial Board	13
CPVT1 point mutations in RyR2 S5 and S6 segments and their Ca2+ signaling consequence	12
Barriers to exocytotic vesicle discharge	12
Calcium signaling and genetic rare diseases: An auditory perspective	12
STIM1: The lord of the rings?	12
High-throughput assessment identifying major platelet Ca2+ entry pathways via tyrosine kinase-linked and G protein-coupled receptors	12
Regulation of the regulator: Endopeptidase cleavage controls the expression of a micropeptide that regulates SERCA.	12
The evolution of organellar calcium mapping technologies	12
Neuronal and astrocyte NCX isoform/splice variants: How do they participate in Na+ and Ca2+ signalling?	12
A NOX2-independent mechanism of Hv1 channel activation promotes inflammatory cytokine release from BV-2 microglia via intracellular Ca2+ mobilisation	12
Unveiling the intricate role of S100A1 in regulating RyR1 activity: A commentary on “Structural insights into the regulation of RyR1 by S100A1”	12
Ablation of mitochondrial calcium uniporter alleviates cardiac dysfunction in type 1 diabetes	11
Editorial Board	11
Scaling up neuronal Ca2+, signaling on ER ladders	11
Changing of the guards while steering a familiar course	11
Transglutaminase 2 controls calcium dependent mitochondrial dysfunction and fibroblast senescence by repressing PIEZO2	10
TRPV2 inhibitor tranilast prevents atrial fibrillation in rat models of pulmonary hypertension	10
Handling a mature calcium signature through optogenetics improves the differentiation of primary murine myotubes	10
Structural snapshots of the mechanism of TRPV2 channel activation by small-molecule agonists	10
Altered composition of the mitochondrial Ca2+uniporter in the failing human heart	10
Calcium influx into astrocytes plays a pivotal role in inflammation-driven behaviors	10
ELD607 specifically traffics Orai1 to the lysosome leading to inhibition of store operated calcium entry	10

Toll-like receptor 4 activation enhances Orai1-mediated calcium signal promoting cytokine production in spinal astrocytes.	9
Distinct pools of synaptic vesicles are released by different calcium channels	9
SERCA2 phosphorylation at the heart of the disease	9
Pan-cancer analysis reveals the prognostic gene CASR suppresses tumor progression and epithelial–mesenchymal transition in renal clear cell carcinoma	9
Multi-neurotransmitter regulation of neural firing via coincidence of parallel G-protein signals	9
Calcium signalling in hepatic metabolism: Health and diseases	9
Regulation of K+-dependent Na+/Ca2+-exchanger subtype 4, NCKX4, by palmitoylation	9
Calcium and chloride out of sync: The role of signaling in Sjögren's salivary gland issues	9
In Memoriam: Irene Schulz 1941 – 2026	9
LETM1 and mitochondrial calcium homeostasis: A controversial but critical role in cellular function and disease	9
Connexin 43 as a novel Ca2+ transport pathway in the nuclear envelope of human induced pluripotent stem cell derived cardiomyocytes	9
Channeling hope for uranium-induced kidney damage and beyond with TRPML1	9
Editorial Board	9
Copine A is essential for calcium homeostasis in Dictyostelium	9
Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7	8
“Functional communication between IP3R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE”	8
Orai1/STIMs modulators in pulmonary vascular diseases	8
Shocking insights for neurovascular coupling: Electrical signals ignite calcium dynamics in brain capillaries	8
CNO induced Ca2+ store and glutamate-dependent nonspecific Ca2+ signalling in DREADD-free brain slices	8
Inhibition of TRPV1 by an antagonist in clinical trials is dependent on cholesterol binding	8
Engulf and digest – TRPM7 as key regulator of macrophage phagosome maturation	8
Uncovering a new route to pain therapy	8
Unravelling the complexity of the mitochondrial Ca2+ uniporter: regulation, tissue specificity, and physiological implications	7
Rhomboid pseudoproteases: An Achilles heel's for BCL-2/IP3R-dependent resistance to ER stress-induced cell death	7
Trace metals and astrocytes physiology and pathophysiology	7
Emerging therapeutics targeting the PI3K/Akt/GSK-3β in calcium dysregulation in Alzheimer’s disease	7
Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7	7
The handshake between the continuous remodeling of the endoplasmic reticulum and the store-operated calcium entry	7
Anoctamin 1, a multi-modal player in pain and itch	7
The dynamic TRPV2 ion channel proximity proteome reveals functional links of calcium flux with cellular adhesion factors NCAM and L1CAM in neurite outgrowth	7
The ryanodine receptor microdomain in cardiomyocytes	7
Interstitial cell of Cajal-like cells (ICC-LC) exhibit dynamic spontaneous activity but are not functionally innervated in mouse urethra	7
Sodium homeostasis and signalling: The core and the hub of astrocyte function	7
Anoctamin pharmacology	6
Excitatory cholinergic responses in mouse primary bronchial smooth muscle require both Ca2+ entry via l-type Ca2+ channels and store operated Ca2+ entry via Orai channels	6
Editorial Board	6
Human IP3 receptor triple knockout stem cells remain pluripotent despite altered mitochondrial metabolism	6
Corrigendum to: Ca2+/calmodulin-driven functions mediated by extracellular vesicles: a physiopathological perspective	6
Editorial Board	6
VDAC2 as a novel target for heart failure: Ca2+ at the sarcomere, mitochondria and SR	6
The STIM1 Phosphorylation Saga	6
Periphery Pre-S1 and S1 helix nexus for PIP2 at TRPC3 channel	6
Control of STIM and Orai function by post-translational modifications	6
Viewing Ca2+-binding sites in the inositol trisphosphate receptor	6
Recognition of granulocyte-macrophage colony-stimulating factor by specific S100 proteins	6
PI(3,5)P2 and NAADP: Team players or lone warriors? – New insights into TPC activation modes	6
Remodeling Ca2+ dynamics by targeting a promising E-box containing G-quadruplex at ORAI1 promoter in triple-negative breast cancer	6
TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluids	6
Astrocytic chloride regulates brain function in health and disease	6
Modulation of carbachol-induced Ca2+ oscillations in airway smooth muscle cells by PGE2	6
Corrigendum to “Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer” [Cell Calcium 102 (2022) 102527]	5
Nuclear Ca2+-Calmodulin signaling in cardiac myocytes reduces catecholamine-evoked protein translation and prevents hypertrophy	5
Enhanced myofilament calcium sensitivity aggravates abnormal calcium handling and diastolic dysfunction in patient-specific induced pluripotent stem cell-derived cardiomyocytes with MYH7 mutation	5
The physiological roles of anoctamin2/TMEM16B and anoctamin1/TMEM16A in chemical senses	5
WNK kinase, ion channels and arachidonic acid metabolites choreographically execute endothelium-dependent vasodilation	5
The role of Ca2+-signaling in the regulation of epigenetic mechanisms	5
Editorial Board	5
Pathological calcium influx through amyloid beta pores disrupts synaptic function	5
Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca2+ stores	5
CaV1.3 enhanced store operated calcium promotes resistance to androgen deprivation in prostate cancer	5
Editorial Board	5
Editorial Board	4
Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells	4
SERCA-1 conformational change exerted by the Ca2+-channel blocker diltiazem affects mammalian skeletal muscle function	4
Epithelial Anoctamins	4
Fura-10, unlike fura-2, is suitable for long-term calcium imaging in natural killer (NK) cells without compromising cytotoxicity and can be combined with target cell death analysis	4
Genomic approachesidentifySTT4 as a new component in glucose-induced activation of yeast plasma membrane H+-ATPase	4
Editorial Board	4
Decline of astrocyte Ca2+ signalling in Alzheimer's disease: STIM1 to the rescue!	4
Pivotal role of the ORAI3-STIM2 complex in the control of mitotic death and prostate cancer cell cycle progression	4
T-type channels in cancer cells: Driving in reverse	4
Exploring the Li+ transporting mutant of NCX_Mj for assigning ion binding sites of mitochondrial NCLX	4
Boosting ER-mitochondria calcium transfer to treat Wolfram syndrome	4
Editorial Board	4
Regulation and role of calcium in cellular senescence	3
Ionic signalling (beyond calcium) in the nervous system: Physiology and pathophysiology	3
Calcium acts as a critical determinant of mitochondria-nuclear networking driven retrograde signaling	3
CRACing the role of calcium signaling in ILC2s	3
Full-fusion and kiss-and-run in chromaffin cells controlled by irreversible vesicle size-dependent fusion pore transitions	3
Anoctamins in epithelial transport	3

The A-kinase anchoring protein Yotiao decrease the ER calcium content by inhibiting the store operated calcium entry	3
Calcium and redox signals at mitochondrial interfaces: A nanoview perspective	3
The many facets of TMEM63/OCaR proteins as mechanosensitive channels in lysosomes, NAADP signaling and beyond	3
Two-pore channels (TPCs) acts as a hub for excitation-contraction coupling, metabolism and cardiac hypertrophy signalling	3
The interplay between associated proteins, redox state and Ca2+ in the intraluminal ER compartment regulates the IP3 receptor	3
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration	3
Roles for TRPV4 in disease: A discussion of possible mechanisms	3
Development of chemical tools based on GSK-7975A to study store-operated calcium entry in cells	3
IP3-dependent Ca2+ signals are tightly controlled by Cavβ3, but not by Cavβ1, 2 and 4	3
Editorial Board	3
Above the legal limit: Alcohol brings ER and mitochondria too close together	3
TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?	3
Calcium signaling in lysosome-dependent cell death	2
In vitro and in vivo calibration of low affinity genetic Ca2+ indicators	2
All-optical mapping of Ca2+ transport and homeostasis in dendrites	2
The quest to map STIM1 activation in granular detail	2
Ca2+ transport via TRPV6 is regulated by rapid internalization of the channel	2
TRPC1: The housekeeper of the hippocampus	2
Tubular aggregate myopathy mutant unveils novel activation and inactivation mechanisms of Orai1	2
You better keep an eye on your contacts	2
MLKL overexpression leads to Ca2+ and metabolic dyshomeostasis in a neuronal cell model	2
PUFAs dictate the balance of power in ferroptosis	2
Editorial Board	2
Subcellular localization and transcriptional regulation of brain ryanodine receptors. Functional implications	2
Editorial Board	2
Human disease-associated calmodulin mutations alter calcineurin function through multiple mechanisms	2
Isoform-specific structure and function of calsequestrin: Implications beyond calcium buffering in health and disease	2
A deep learning-based approach for efficient detection and classification of local Ca²⁺ release events in Full-Frame confocal imaging	2
Fine tuning calcium dynamics by inhibition of Store-operated Calcium Entry as a novel therapeutic approach for the treatment of chronic pancreatitis	2
Orai1 plays a critical role in Orai3 synthesis and stability in luminal breast cancer cells	2
Campari2 genomic interrogation of homeostatic calcium activity identifies TIM1 as a negative regulator of T cell function	2
The dual role of transient receptor potential melastatin cation channels in sepsis	2
Stable expression of SARS-CoV-2 envelope viroporin promotes intracellular calcium depletion in human cells: relevance for endoplasmic reticulum stress, cell proliferation, pluripotency and lineage dif	2
Title: Jealous protons sour another happy marriage; the story of how TRPV5 and PI(4,5)P2 split up.	2
“Gatekeepers of heaven” breaking bad	2
NAADP signaling: Master manipulation	2
STIM1 is the key that unlocks airway smooth muscle remodeling and hyperresponsiveness during asthma	2
The role of Ca2+ signalling in the pathology of exocrine pancreas	2
IN BRAIN POST-ISCHEMIC PLASTICITY, Na+/Ca2+ EXCHANGER 1 AND Ascl1 INTERVENE IN MICROGLIA-DEPENDENT CONVERSION OF ASTROCYTES INTO NEURONAL LINEAGE	2
TREM2 and calcium signaling in microglia – is it relevant for Alzheimer's disease?	2
Endothelial PIEZO1 activation impairs osteogenesis via GREM1-mediated inhibition of BMP signaling	2
Nanojunctions: Specificity of Ca2+ signaling requires nano-scale architecture of intracellular membrane contact sites	2
Ca2+ signaling and cell death	2
Is Zn2+ the new Ca2+ for TRPC6 channels in the myocardium?	2