Placenta

Article	Citations
A 3D culture model to study uterine gland cells as signaling agents in embryo-endometrium relationship	72
Editorial Board	59
Effect of heat stress during late gestation on placentome morphometry of multiparous dairy cattle in a pasture-based system	56
Exploring Placental DNA Methylation in IVF Pregnancies Reveals Male-Specific CpG Signatures and Increased Female Variability	51
Effects of Placenta-Derived Factors on Maternal Megakaryocytes and Thrombopoiesis	46
Swine trophoblast organoids as a robust, physiologic model of porcine placental development	42
Targeted delivery of liposomes to the uterine artery of pregnant rhesus macaques	39
Chronic gestational inflammation: Comparisons of obesity-mediated and preeclampsia-mediated placental inflammation using transcriptomic and histological methods	38
“Optimal timing for RNA isolation: Recommendations for placenta sample collection under clinical conditions”	33
Immunosuppressant drug tacrolimus inhibits HUVEC angiogenesis and production of placental growth factor	31
Medroxyprogesterone Acetate Suppresses Inflammatory Cytokine Expression in Amniotic Mesenchymal Cells	30
Characterization and in vitro modeling of trophoblast and villous core networks of human first trimester placental cells	29
IFPA Pages	27
Pneumocystis is a frequent fungal colonizer of the human placenta at term	27
Novel 3D in vitro human placenta-on-a-chip model derived using human trophoblast stem cells differentiated towards syncytiotrophoblasts and extravillous trophoblasts to mimic both villi and implantati	26
Detection of heat-stable antibacterial activity in cotyledonary and discoid placentas	26
Lack of CB1 receptor reduces preterm birth rate in an LPS-induced murine model	26
Composition of circulating short-chain fatty acids in gestational diabetes mellitus and their associations with placental immune-metabolic responses	26
A case of pregnancy-related acute kidney injury following a missed abortion	25
Prediction of maternal and foetal outcomes among patients with preeclampsia using circulatory biomarkers (MMP-9 & ST2) - A prospective cohort study	25
Fetoplacental vascular reactivity is altered in fetuses with congenital diaphragmatic hernia	24
Extracellular vesicle signalling and pregnancy- engineering the opportunities	24
Effects of high-fat diets on placenta and fetal development in female swiss mice	24
Necroptosis associates with infection severity and birth outcomes in placental malaria	23
Comparative study of sialic acid content in saliva between preeclampsia and normal gestation patients	23

Role of osteopontin (OPN) in uterine spiral artery remodeling	23
Editorial Board	23
Higher long-term blood pressure in women with recurrent preeclampsia than who with single episode of preeclampsia	22
Nitric oxide donor increases umbilical vein blood flow and fetal oxygenation in fetal growth restriction. A pilot study	22
Maternal nutrient restriction in guinea pigs increases resistance in the umbilical artery at mid-gestation.	22
Development of novel AOX1 inhibitors to prevent or reverse placental oxidative damage	22
Analysis of podocyte injury and inflammatory response in a mouse model of preeclampsia using electron microscopy	21
Comprehensive analyses of DNA methylation of the TIMP3 promoter in placentas from early-onset and late-onset preeclampsia	21
Gardnerella vaginalis impairs extravillous trophoblast invasion via extracellular matrix-mediated MMP2 downregulation	21
Pre-natal dietary imbalance of folic acid and vitamin B12 deficiency adversely impacts placental development and fetal growth	21
Different risk of acute feto-fetal transfusion in basic clinical subtypes of monochorionic twins	21
Potential resolution of placenta previa from the 28th-to the 36th-week of pregnancy: A retrospective longitudinal cohort study	21
Unveiling placental development in circadian rhythm-disrupted mice: A photo-acoustic imaging study on unstained tissue	21
Achieving multifunctionality in a single, tissue-sized syncytiotrophoblast cell in humans	20
Presepsin in the amniotic fluid is a useful clinical inflammatory biomarker for the prenatal predictive diagnosis of histologic chorioamnionitis: a retrospective preliminary study	20
Insights into embryo-endometrium immune interactions	20
Placental deficiency during maternal SARS-CoV-2 infection	19
Ferumoxytol-enhanced MRI of retroplacental clear space disruption in placenta accreta spectrum	19
Placental pathological findings in triplet pregnancies conceived through assisted reproductive technology: a study of 98 cases	19
Exosome enriched leucine-rich alpha-2-glycoprotein-1 and extracellular matrix protein 1 proteins induce abnormal placental angiogenesis in pregnant mice	19
Low oxygen-induced ferritinophagy is responsible for heightened ferroptosis in the placenta in fetal growth restriction	19
The whole is lesser than the sum of its parts? Dissecting layer-enriched samples of rodent placenta is worth the effort	19
The overview of lactylation in the placenta of preeclampsia	19
Latent profile analysis of newborn dried blood spot (DBS) cyto-and chemo-kines and growth factors and maternal and fetal acute inflammatory responses to amniotic fluid infection.	19
Investigating the effects of beta blockers on fetal vasculature	18
Placenta accreta after hysteroscopic surgery for intrauterine adhesion	18
Characterization and in vitro modeling of trophoblast and villous core networks of human first trimester placental cells	18
Placental extracellular vesicles induce ovarian tumour cell death in an ex vivo explant model: Possible therapeutic potential	17
Association between maternal consumption of ultra-processed foods, lipid biomarkers of de novo lipogenesis in plasma and human milk, and postpartum depression: Investigation in a Brazilian cohort of p	17
Editorial Board	17
METTL3 suppressing SLC31A1 m6A modification regulates trophoblast migration and invasion	17
Velocity-selective arterial spin labeling perfusion measurements in 2nd trimester human placenta with varying BMI	17
Spheroid formation induces chemokine production in trophoblast-derived Swan71 cells	17
Metformin ameliorates trophoblastic immunometabolic disorders via attenuating TLR4/NF-κB signaling through ATXN7L3-mediated histone H2B monoubiquitination	17
The differential placental expression of ERp44 and pre-eclampsia; association with placental zinc, the ERAP1 and the renin-angiotensin-system	16
Trypanosoma cruzi induced trophoblast differentiation is mediated by MIR-19B	16
Single-cell RNA sequencing reveals altered placental microenvironment due to maternal high-fat diet	16
Deep learning for fetal inflammatory response diagnosis in the umbilical cord	16
Are there differences between monochorionic twin placentas after spontaneous and assisted conception?	16
Whole transcriptome analysis of trophoblasts under hypoxia	16
The impact of maternal Zika virus infection on long-term neurodevelopment:	16
Altered release of thrombomodulin and HMGB1 in the placenta complicated with preeclampsia	16
Protocol for the quantitative analysis of images retrieved by multiplex immunofluorescence staining to allow cell type-specific spatial phenotyping of markers of interest in the human placenta	16
Corrigendum to PVT1/miR-145-5p/HK2 modulates vascular smooth muscle cells phenotype switch via glycolysis: The new perspective on the spiral artery remodeling [Placenta 130 (2022) 25–33]	15
Villitis of unknown etiology, chronic deciduitis, chronic chorioamnionitis and chronic histiocytic intervillositis in monozygotic and dizygotic twin pregnancies. A retrospective analysis of 16 cases	15
Stress regulation of WFS1 and PERK-p-eIF2α-ATF4 signaling pathway in placental tissue cells of intrahepatic cholestasis of pregnancy	15
Trophoblast-mediated spatial changes in hydrogel matrix properties	15
The production of angiogenic and antiangiogenic factors via the activation of protein kinase C in the placenta of pregnant diabetic mice	15
Butyrate increases maternal liver lipid accretion and ameliorates fetal markers of fatty liver programming	15
DNMT1-mediated DNA methylation contributes to CYP11A1 expression in progesterone synthesis in placental trophoblast syncytialization	15

Letter to the editor on “The MRI estimations of placental thickness and cervical length correlate with postpartum hemorrhage (PPH) in patients with risk for placenta accreta spectrum (PAS) disorders”	15
Developing of a novel therapeutic agent for FGR through Drug repositioning	15
Placental pathology findings amongst extremely preterm perinatal deaths in Aotearoa New Zealand	15
Detecting abnormal placental microvascular flow in maternal and fetal diseases based on flow-compensated and non-compensated intravoxel incoherent motion imaging	15
A retrospective study of manual removal or expectant management for retained product of conception after the third trimester delivery	15
Placental Aquaporin-3: A potential molecular target for aspirin in the treatment of preeclampsia	14
Gestational chronodisruption and its role in fetal programming of non-communicable diseases	14
ARID1A recruits GATA2 to regulate the senescence of trophoblast cells under high-glucose condition	14
The role of glutamitc oxaloacetic transaminase in placentas of pregnancies complicated with IUGR	14
Role of bacterial chorioamnionitis in the physiopathology of neurodevelopmental disorders of the offspring	14
Late gestation heat stress alters O2 regulation in placenta and neonatal heifers	14
COVID in pregnancy: Biomarkers of placental dysfunction and neonatal outcomes	14
Human implantation: The complex interplay between endometrial receptivity, inflammation, and the microbiome	14
Editorial Board	14
Morphological and functional changes in placentas from prolonged pregnancies	13
Placental human papillomavirus infections and adverse pregnancy outcomes	13
Chronic intervillositis of unknown etiology in patients with recurrent pregnancy loss: Impact on reproductive outcomes, treatment efficacy, and recurrence rates	13
Prenatal exposure to perceived stress, maternal asthma, and placental size	13
A novel technique to estimate intravillous fetal vasculature on routine placenta histologic sections	13
Upregulation of METTL14 contributes to trophoblast dysfunction by elevating FOXO3a expression in an m6A-dependent manner	13
NNMT expression in preeclampsia: Analyses on placental tissues and cell lines	13
Placental correlates in categories of preterm births based on gestational age	13
Hydrogen sulfide promotes migration of trophoblast cells by a Rho GTPase mediated actin cytoskeleton reorganization	13
Placental weight as a predictor of future health: Insights from a large-scale genome-wide association study	13
Establishment of human trophoblast stem cells from term smooth chorion	12
Analysis of Non-Coding RNAs in Placental Tissue and Extracellular Vesicles: Implications for Trophoblast Function	12
Deep proteomic characterization of placenta tissue from patients with preeclampsia	12
ZKSCAN1 expression in placentae of preeclampsia pregnant women: implications in the pathogenesis of preeclampsia	12
Trophoblast-specific overexpression of Slc7a5 (LAT1) causes fetal overgrowth by increasing fetal plasma levels of circulating essential amino acids	12
ASCT2-dependent secretion mechanism of the cell fusion-regulator suppressyn	12
Differences in syncytiotrophoblast shear stress and mechanosensing protein expression in fetal growth restriction.	12
Small RNAs in the pathogenesis of preeclampsia	12
Single-cell spatial mapping of trophoblast subpopulations in the human placenta using HybISS	12
Cargo changes in placental extracellular vesicles due to antiphospholipid antibody treatment may reflect differential functionality of different vesicle subtypes	12
Excess folic acid mimics deficiency in human placenta in vitro	12
SKAP2 is downregulated in the villous tissues of patients with missed abortion and regulates growth and migration in trophoblasts through the WAVE2-ARP2/3 signaling pathway	11
Endotheliochorial placental glycosylation reflects evolutionary divergence between Felidae species (Felis catus and Panthera leo) and Canidae (Canis familiaris)	11
Vaccination by a Zika purified inactivated virus both before and during pregnancy in the common marmoset monkey is associated with relatively normal placental morphology: a preliminary stereological a	11
Uteroplacental versus fetal use of glucose in healthy pregnancies at term. A human in vivo study	11
Transcriptional specialization of nuclei in the giant, multinucleated syncytiotrophoblast cell	11
Follistatin dysregulation impaired trophoblast biological functions by GDF11-Smad2/3 axis in preeclampsia placentas	11
Buprenorphine and the placenta: does MAT in pregnancy impact placental efficiency?	11
The heart-placenta axis is dysregulated in a conditional Hand1 mutant model of FGR	11
The influence of adiponectin in metabolic parameters of pregnant women with mild gestational hyperglycemia and gestational diabetes mellitus	11
HtrA4 is required for differentiation of human trophoblast stem cells into syncytiotrophoblast	11
Clinical course of placenta accreta cases managed expectantly for seven days or longer	11
The role of aryl hydrocarbon receptors in nutrient metabolism and immune regulation at the maternal–fetal interface	11
Porphyromonas gingivalis lysate induces tissue disorganization and proinflammatory response in human placental explants	11
Fibroblast activating protein (FAP) is reduced in FGR in regions of the villous tree with disturbed differentiation of perivascular myofibroblasts	11
Polymorphisms of hypertension susceptibility genes as a risk factors of preeclampsia in the Caucasian population of central Russia	11
TREM-1 amplifies trophoblastic inflammation via activating NF-κB pathway during preeclampsia	11
Upregulation of placental Ski-like proto-oncogene in preterm preeclampsia: potential target for preeclampsia treatment?	10
Editorial Board	10
The role of creatine in placental energy metabolism at birth: Initial insights from the Creatine and Pregnancy Outcomes (CPO) cohort study of low-risk pregnancy	10
AQP4 and AQP9 positive-extracellular vesicles in preeclampsia	10
Epigenetic effects of exercise on improving the adverse placental environment associated with maternal overweight and obesity	10
Impact of tissue porosity and asymmetry on the oxygen uptake of the human placenta: A numerical study	10
Antenatal melatonin supplementation increases fetal weight and reduces placental oxidative damage in a mouse model of advanced maternal age	10
Novel approaches to obstetric drug design and development	10
Comments on “Prenatal interventions for fetal growth restriction in animal models: A systematic review”	10
Corrigendum to “Visual assessment of the placenta in antenatal magnetic resonance imaging across gestation in normal and compromised pregnancies: Observations from a large cohort study” [117 January 2	10
Nutrition and neurodevelopment: Participation of vitamin E in the differentiation of the early brain	10
Placentas from women of advanced maternal age (AMA) show increased activation of the unfolded protein response (UPR) but this is not exacerbated in the presence of Fetal Growth Restriction (FGR).	10
Maternal, placental, and fetal distribution of titanium after repeated titanium dioxide nanoparticle inhalation through pregnancy	10
Maternal care of the whole litter improves the success rate of diabetes in pregnancy in rats	10
IFPA Pages	10
Explorative 3-D culture of early secondary follicles in a time lapse system for up to 36 days gives valuable, but limited insights in follicular development	10
Title Page/Editorial Board	10
Exposure to fine particulate matter 2.5 from wood combustion smoke causes vascular changes in placenta and reduces fetal size	9
Genetic profiling of Plasmodium falciparum antigenic biomarkers among asymptomatic pregnant women on intermittent preventive treatment with sulfadoxine-pyrimethamine from southwest Nigeria	9
Placental extracellular vesicles promoted cervical tumour tissue undergoing death	9
Trend: A test for recurrent implantation failure patients’ detection by qPCR array	9
Molecular insights into the corin function at the uteroplacental interface	9
Characterizing placental NLRP3 inflammasome and lipidome dynamics: Insights from glucose, metformin, and LPS exposure in placental explants	9
Characterization and expression of thyroid hormone transport in HTR8/SVneo trophoblast cells under hyperinsulinemia conditions	9
Editorial Board	9
Meta-analysis on COVID-19-pregnancy-related placental pathologies shows no specific pattern	9
Circular RNAs (circRNAs) cause DNA damage and characterise accelerated ageing in stillbirth placenta	9
Melatonin-treated trophoblast extracellular vesicles signaling mediates macrovascular and microvascular endothelial cell migration	9
Pulmonary trophoblastic deportation in the hystricomorph rodent Lagostomus maximus	9

HLA-G isoforms, HLA-C allotype and their expressions differ between early abortus and placenta in relation to spontaneous abortions	9
A case of fetal growth restriction with placental confined mosaicism	9
Morphology and evolutionary aspects of the yolk sac in dogs	9
First trimester extravillous trophoblast secretes HLA class I molecules via small extracellular vesicles	9
Activin A promotes human trophoblast invasion by upregulating integrin β3 via ALK4-SMAD4 signaling	9
Placental dysfunction: The core mechanism for poor neurodevelopmental outcomes in the offspring of preeclampsia pregnancies	9
Unravelling the Protective Role of Placental ACE2 During Chronic Hypoxia/Reoxygenation	9
Vitamin D metabolites and oxidized polyunsaturated fatty acids in plasma and human milk: Implications for the metabolic and mental health of the mother and infant development in the first six months p	9
OLFML3 suppresses trophoblast apoptosis via the PI3K/AKT pathway: A possible therapeutic target in preeclampsia	9
Cytotoxicity and induction of proinflammatory cytokines in placental explant cells following azathioprine exposure	9
The proinflammatory cytokines IFN-α and TNF-α inhibit extravillous trophoblast invasion	9
Gastroschisis associated changes in the placental transcriptome	9
In vitro evaluation of the effect of oxygen concentrations on thrombomodulin expression in a first-trimester trophoblast cell line	9
Ultrasound evaluation of pathophysiology in fetal thrombo-vasculopahy due to umbilical cord abnormalities	9
Mid-late gestation leptin infusion induces placental mitochondrial and endoplasmic reticulum unfolded protein responses in a mouse model of preeclampsia	8
Editorial Board	8
Fetal growth restriction and a single umbilical artery are independent predictors of hypospadias during pregnancy	8
Analyzing the Relationship Between Preeclamptic Severity and Placental Methylation	8
Oxidative stress microenvironment responsive multifunctional nanoparticles for targeted prevention and treatment preterm birth caused by placental inflammation	8
Cesarean scar pregnancy successfully managed to third-trimester	8
1,25(OH)2D3 alleviates LPS-induced preeclampsia-like rats impairment in the protective effect by TLR4/NF-kB pathway	8
Sexually dimorphic alterations in placental senescence pathways in Gestational Diabetes Mellitus (GDM)	8
Joan Hunt Senior award lecture: New tools to shed light on the ‘black box’ of pregnancy	8
Characterization of micro-haemodynamics in the placental intervillous space by integrated experimental and theoretical approaches	8
Down-regulation of MYO1A inhibits trophoblast cell proliferation and migration through SMURF2/Hedgehog signaling pathway and leads to fetal growth restriction	8
Clinical Significance of stage 1 Maternal inflammatory response in placenta	8
Role of exosomes in placenta-maternal body axis for organ specific damage of preeclampsia	8
Placental metabolomics from women with gestational diabetes mellitus unveils glycolytic and one-carbon metabolism impairment	8
Attenuation of murine placental MDR1 and BCRP functions by their unique protein localization	8
Gelatin methacryloyl biomaterials and strategies for trophoblast research	8
Chronic inflammation of the male genital tract impairs female genital tract immunomodulation and decrease fertility potential	8
First-trimester 3D power Doppler imaging markers of utero-placental vascular development are associated with placental weight and diameter at birth: The Rotterdam Periconception Cohort	8
Maternal disadvantage and pregnancy outcomes in two Australian pregnancy cohorts	8
Placental lesions induced by Omicron SARS-CoV-2 in a pregnant woman treated with anti-CD20	8
Dissecting the microenvironment of gestational trophoblastic disease through deconvolution of bulk RNA-seq data	8
Volume analysis and three-dimensional imaging of the migration process of bovine trophoblast giant cells at mid and end of gestation	8
A case of high-grade VUE diagnosed by additional immunostaining rather than H&E staining alone	8
First trimester placental extracellular vesicles likely contribute to the vasodilation of maternal resistance arteries in normal pregnancy	8
Increased NPC1 and STARD3 expression in placentas from women with Maternal Supraphysiological Hypercholesterolemia (MSPH) promotes lysosomal and mitochondrial dysfunction.	8
Transmission electron microscopy demonstration of reduced endothelial glycocalyx in severe preeclampsia	8
Astrocyte and microglia activation by circulating extracellular vesicles from preeclampsia exacerbates blood-brain barrier disruption on a microfluidic BBB-on-chip model	8
miR-2115-3p inhibits ferroptosis by downregulating the expression of glutamic-oxaloacetic transaminase in preeclampsia	7
Toxoplasma gondii infection of human placental explants is mediated by MIR-190B expression	7
Placental assessment using spectral analysis of the envelope of umbilical venous waveforms in sheep	7
Placental damage in pregnant women with SARS-CoV-2 infection: Comment	7
Maternal C1q deficiency leads to impaired decidual vascular remodelling, placental insufficiency and reduced fetal growth.	7
Placentae of small appropriately-grown-for-gestational-age neonates exhibit sexually dimorphic transcriptomic changes representative of placental insufficiency	7
Maternal dietary olive oil protects diabetic rat offspring from impaired uterine decidualization	7
Immunoregulation of the decidualization program: Impact of the reticular stress and senescence in endometrial receptivity	7
Developmental programming of the offspring´s health and disease by maternal obesity	7
Placental biophysical model for prediction of early onset fetal growth restriction in first and second trimester of pregnancy: A prospective cohort study	7
A crossroad between placental and tumor biology: What have we learnt?	7
Author index	7
Second trimester cell-free placental DNA methylation profiles in preterm birth subtypes	7
Artery-to-vein anastomoses in unequally divided placentas and their association with birthweight discordance	7
Third-trimester side-population trophoblasts can be differentiated to mature trophoblast lineages and show reduced growth in FGR.	7
Placental transfer and metabolism of betamethasone in healthy and preeclamptic human placentas	7
Correlation of amniotic fluid index and placental aquaporin 1 levels in terms of preeclampsia	7
Fluidic cellular in vitro model resembling the maternal-fetal interface	7
Compensatory expansion of the cotyledonary surface in response to nutritional restriction in multiparous pregnant beef cows	7
Maternal Folate Status and the Prevalence of Gestational Diabetes Mellitus: Insights from Australian Pregnancy Cohorts	7
Thinking outside the box: The placenta responds to injury with proinflammatory cytokines even when the environment is immunosuppressive	7
Obituary to the IFPA Journal: Placenta - Date: August 16, 2024	7
Hypoxic placental small extracellular vesicles disrupt the blood-brain barrier in the frontal area of the brain	7
Placental pathology findings in perinatal deaths from 28 weeks gestation in Aotearoa New Zealand	7
Regulatory mechanisms underlying endoplasmic reticulum stress involvement in the development of gestational diabetes mellitus entail the CHOP-PPARα–NF–κB pathway	7
Levels of mtDNA, mitofusin -2 and presence of lipid vacuole in the placental tissue of obese pregnant women	7
Viruses may cause a significant proportion of chronic inflammatory pathology in the placenta	7
Placental slice techniques in physiology, pathophysiology, and toxicology: A systematic review with a focus on precision-cut slices	7
The study of clinical outcome in cases of placenta previa	7
Placenta in ZIKV infection: From women to mice	7
Investigating the effects of microplastic accumulation on women's health during pregnancy	7
Computational analysis identified accelerated senescence as a significant contribution to preeclampsia pathophysiology	6
Dysregulation of placental mitochondrial structure dynamics and clearance in maternal obesity and gestational diabetes	6
Extracellular vesicle collection from ex vivo human placenta perfusion	6
Comprehensive Analysis of decidua in ectopic pregnancies reveals role of ATG2A	6
A standardization protocol for the immunohistochemical localization of 11Β-HSD type II enzyme in human term placenta	6
Preeclampsia: The silent catalyst for autism spectrum disorder in offspring	6
High beta-amyloid(1–40) cerebrospinal fluid concentrations precede increase of serum biomarkers in a case with severe HELLP syndrome	6
Maternal hypothyroidism in rats impairs placental nutrient transporter expression, increases labyrinth zone size, and impairs fetal growth	6
Prenatal interventions for fetal growth restriction in animal models: A systematic review	6
Exploring the Interplay Between the Endocannabinoid and Immune Systems in the Placenta Using Ex Vivo and In Vitro Models	6
Placenta may exert fetal protection against maternal high salt diet intake via renin-angiotensin-aldosterone system	6
Placental transfer of chemicals: Ex vivo placental perfusion model	6
Glycaemic dynamics in women with gestational diabetes mellitus	6
The protective mechanism of human umbilical cord mesenchymal stem cell-derived exosomes against neutrophil extracellular trap-induced placental damage	6
Morphological placental findings in women infected with SARS-CoV-2 according to trimester of pregnancy and severity of disease	6
Correlation of placental lesions in patients with systemic lupus erythematosus, antiphospholipid syndrome and non-criteria obstetric antiphospholipid syndrome and adverse perinatal outcomes	6
Lipidomic profiling of preeclamptic placenta according to severe features	6
Non-vesicle extracellular nanoparticles serve as carriers for placenta-specific microRNAs: in vitro analysis using trophoblast cell line BeWo	6
The Placenta-Brain Axis	6
Histological characteristics of the placental terminal villi from obese women	6
Placental lesions associated with stillbirth by gestational age, according to feature importance: Results from the stillbirth collaborative research network	6
Correlative three-dimensional X-ray histology (3D-XRH) as a tool for quantifying mammalian placental structure	6
Review: The potential role of placental extracellular vesicles in blood-brain barrier disruption and neuroinflammation in preeclampsia	6