OOIR: Observatory of International Research

Papers

(The TQCC of Carcinogenesis is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Editor-In-Chief’s Editorial 2023	50
miR-1304 targets KLK11 to regulate gastric cancer cell proliferation through the mTOR signaling pathway	40
Regulatory mechanisms of PFKFB2 in glycolysis and tumor metabolism: implications for cancer therapy	38
O-GlcNAcylation of RAB10 promotes hepatocellular carcinoma progression	30
LINC02418 upregulates EPHA2 by competitively sponging miR-372-3p to promote 5-Fu/DDP chemoresistance in colorectal cancer	30
Longitudinal single-cell RNA model aids prediction of EGFR-TKI resistance	27
Cancer-testis non-coding RNA LEF1-AS1 regulates the nuclear translocation of PDCD5 and suppresses its interaction with p53 signaling: a novel target for immunotherapy in esophageal squamous cell carci	27
The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model	25
Prognostic value of circulating tumor DNA in different cancer types detected by ultra-low-pass whole-genome sequencing: a systematic review and patient-level survival data meta-analysis	23
miR-22 promotes immunosuppression via activating JAK/STAT3 signaling in cutaneous squamous cell carcinoma	22
Correction to: Triple-negative breast cancer molecular subtypes and potential detection targets for biological therapy indications	22
Redefining pancreatic cancer management with tumor-agnostic precision medicine	20
Identification of HCAR1 as a ferroptosis-related biomarker of gastric cancer based on a novel ferroptosis-related prognostic model and in vitro experiments	20
Expression of Concern: The promoting effects of hsa_circ_0050102 in pancreatic cancer and the molecular mechanism by targeting miR-1182/NPSR1	20
Long non-coding RNA NRAV in the 12q24.31 risk locus drives gastric cancer development through glucose metabolism reprogramming	19
Association between new plasma inflammatory markers and risk of colorectal neoplasms in individuals over 50 years old	19
Editor-in-Chief’s Note—Thank you to Reviewers	19
SIAH1/CTR9 axis promotes the epithelial–mesenchymal transition of hepatocellular carcinoma	18
Ehm2 transcript variant 1 inhibits breast cancer progression and increases E-cadherin stability	18
Machine learning based on biological context facilitates the identification of microvascular invasion in intrahepatic cholangiocarcinoma	17
The tumour microenvironment in paediatric rhabdomyosarcomas: a systematic review	17
LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism	17
Solamargine enhanced gefitinib antitumor effect via regulating MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway in non-small cell lung cancer	16
Long noncoding RNA XIST: a novel independent prognostic biomarker for patients with ABC-DLBCL receiving R-CHOP treatment	16
α5-nAChR/STAT3/CD47 axis contributed to nicotine-related lung adenocarcinoma progression and immune escape	16

miR-3154 promotes hepatocellular carcinoma progression via suppressing HNF4α	16
Establishing a new-onset diabetes-related metabolism signature for predicting the prognosis and immune landscape in pancreatic cancer	15
Intratumoral vitamin D signaling and lethal prostate cancer	15
Antibody–drug conjugates in breast cancer	14
Urinary glyphosate levels and association with mortality in the 2013–16 National Health and Nutrition Examination Survey	14
SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer	14
MPZL1 upregulation promotes tumor metastasis and correlates with unfavorable prognosis in non-small cell lung cancer	14
ITGA2 as a prognostic factor of glioma promotes GSCs invasion and EMT by activating STAT3 phosphorylation	14
DUT enhances drug resistance to proteasome inhibitors via promoting mitochondrial function in multiple myeloma	14
Prognostic value of exosomal noncoding RNA in hepatocellular carcinoma: a meta-analysis	14
SLC38A6, regulated by EP300-mediated modifications of H3K27ac, promotes cell proliferation, glutamine metabolism and mitochondrial respiration in hepatocellular carcinoma	14
PPM1G promotes the progression of lung adenocarcinoma by inhibiting p38 activation via dephosphorylation of MEK6	14
Copine 1 predicts poor clinical outcomes by promoting M2 macrophage activation in ovarian cancer	14
Immune-related genes for the prediction of response to imatinib therapy in chronic myeloid leukemia	13
MALAT1 regulates network of microRNA-15a/16–VEGFA to promote tumorigenesis and angiogenesis in multiple myeloma	13
CYR61 confers chemoresistance by upregulating survivin expression in triple-negative breast cancer	13
Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells	13
Genetic variants in glycosylation pathways are associated with colorectal cancer risk	13
Outcome of clinical experience of introducing a patient with secondary systemic AL-amyloidosis associated with multiple myeloma	13
Actinomycin D synergizes with Doxorubicin in triple-negative breast cancer by inducing P53-dependent cell apoptosis	13
BRAF V600E-induced distinct DNA damage response defines the therapeutic potential of p53 activation for TP53 wild-type colorectal cancer	13
Genomic and transcriptomic characterization of gamma ray- and heavy-ion-induced precursor B-cell lymphomas in B6C3F1 mice: radiation-type-dependent interstitial chromosomal deletions at tumor-suppress	13
Germline alteration analysis reveals EPHB4R91H mutation as a key player in multiple primary lung tumors	12
CacyBP promotes the development of lung adenocarcinoma by regulating OTUD5	12
From precursor to cancer: decoding the intrinsic and extrinsic pathways of pancreatic intraepithelial neoplasia progression	12
SSH1 promotes progression of intrahepatic cholangiocarcinoma via p38 MAPK-CXCL8 axis	12
Sevoflurane inhibits lung cancer development by promoting FUS1 transcription via downregulating IRF6	12
The impact of reproductive factors on breast tumor and normal-adjacent tissue immune profile from menarche to menopause	12
LncRNA-encoded peptide LRRC75A-AS1-ORF3 suppresses anti-tumor immunity in colorectal cancer through mitophagy-mediated attenuation of cGAS-STING signaling	12
MAPK3 modulates enhancer–promoter interactions of SKAP2 in acute myeloid leukemia	11
LncRNA CCAT1 participates in pancreatic ductal adenocarcinoma progression by forming a positive feedback loop with c-Myc	11
SMARCA4/BRG1 deficiency induces a targetable dependence on oxidative phosphorylation in clear cell renal cell carcinoma	11
Characteristic genetic alterations associated with the partial deletion of chromosome 11 in mouse thymic lymphomas induced by high-linear energy transfer irradiation with carbon ions	11
Dietary phytoestrogen intake and ovarian cancer risk: a prospective study in the prostate, lung, colorectal and ovarian (PLCO) cohort	11
Elevated expression of the membrane-anchored serine protease TMPRSS11E in NSCLC progression	11
Correction to: p62/SQSTM1 interacts with vimentin to enhance breast cancer metastasis	11
AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer	11
Somatic p53 mutations that are markedly overrepresented in lung cancer confer resistance to reactive oxygen species-induced cell death	10
Cancer-associated fibroblasts promote cancer stemness by inducing expression of the chromatin-modifying protein CBX4 in squamous cell carcinoma	10
LncRNAs act as modulators of macrophages within the tumor microenvironment	10
A polymorphic variant in telomere maintenance is associated with worrisome features and high-risk stigmata development in IPMNs	10
Copper in colorectal cancer patients: a systematic review and meta-analysis	10
Expression profile of Claudins 3, 4, and 7 in breast tumors and its correlation with clinicopathological features	9
Pan-cancer analysis of G6PD carcinogenesis in human tumors	9
Comparison of radiation-related cancer risks from the atomic bomb survivors with studies of pediatric medical radiation exposure	9
ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment	9
Tumor-associated astrocytes inhibit tumor cell apoptosis through TNF-α–TNF receptor 2–NF-κB pathway in lung cancer brain metastasis	9
Macrophage migration inhibitory factor as a prognostic biomarker in multiple myeloma: clinical significance and in vitro effects	9
NamiRNA-enhancer network of miR-492 activates the NR2C1-TGF-β/Smad3 pathway to promote epithelial-mesenchymal transition of pancreatic cancer	9
Stem cells, Notch-1 signaling, and oxidative stress: a hellish trio in cancer development and progression within the airways. Is there a role for natural compounds?	9

Triple-negative breast cancer molecular subtypes and potential detection targets for biological therapy indications	8
Symposium report—ethical and social considerations regarding return of secondary findings in atomic bomb survivors	8
Overview and future studies of potential hereditary effects of parental exposure to atomic bomb radiation on their offspring	8
Associations of prediagnostic serum liver enzyme levels with lung cancer risk in predominantly low-income African and European Americans	8
Adverse events and recent advances in CAR-T-cell therapy	8
CRL4DCAF4 E3 ligase-mediated degradation of MEN1 transcriptionally reactivates hTERT to sustain immortalization in colorectal cancer cells	8
BRINP3 promotes lung adenocarcinoma by enhancing CLOCK-mediated transcriptional regulation of CRYZL1 and activating the AKT pathway	8
m6A-modified circASXL1 promotes proliferation and migration of ovarian cancer through the miR-320d/RACGAP1 axis	8
Bipolar high-frequency electric welding in radical resection of frontal sinus tumors	8
Olfactomedin 4 promotes gastric cancer cell G2/M progression and serves as a therapeutic target in gastric adenocarcinoma	8
Role of P450 enzymes of the Cyp2abfgs gene subfamilies in tobacco smoke-induced lung tumorigenesis in mice	8
E3 ubiquitin ligase RNF148 functions as an oncogene in colorectal cancer by ubiquitination-mediated degradation of CHAC2	8
Targeted sequencing and functional interrogation identified novel variant at 12q14.2 associated with risk of ovarian cancer in Han Chinese women	8
Integrative analysis of enrichment and prognostic value of ferroptosis-related genes and pathways in multiple myeloma	7
TMEM16A inhibits autophagy and promotes the invasion of hypopharyngeal squamous cell carcinoma through mTOR pathway	7
Plasma thioredoxin reductase: a potential diagnostic biomarker for gastric cancer	7
SNCA inhibits epithelial–mesenchymal transition and correlates to favorable prognosis of breast cancer	7
The influence of homologous recombination repair on temozolomide chemosensitivity in gliomas	7
LncRNA UCA1 promotes vasculogenic mimicry by targeting miR-1-3p in gastric cancer	7
HS-10296 (almonertinib) enhances radiosensitivity in EGFR-mutant nonsmall cell lung cancer (including T790M) through inhibition of EGFR downstream signaling and DNA damage repair	7
Morphology dynamics in intestinal crypt during postnatal development affect age-dependent susceptibility to radiation-induced intestinal tumorigenesis in Apc Min/+ mice	7
Thymoquinone inhibits lung cancer stem cell properties via triggering YAP degradation	7
CCL18 promotes migration and invasion of multiple myeloma cells and is associated with poor prognosis	7
Dual activation of autophagy and mTOR by TFE3 fusions promotes tumorigenesis in rearranged renal cell carcinoma	7
CDK12 is a promising therapeutic target for the transcription cycle and DNA damage response in metastatic osteosarcoma	7
Mechanisms of tumor-associated macrophages promoting tumor immune escape	7