Carcinogenesis

Article	Citations
Editor-In-Chief’s Editorial 2023	62
Intermittent administration of tacrolimus enhances 
anti-tumor immunity in melanoma-bearing mice	41
Genomic profile of radiation-induced early-onset mouse B-cell lymphoma recapitulates features of Philadelphia chromosome-like acute lymphoblastic leukemia in humans	39
Identification of biomarkers for the diagnosis and targets for therapy in patients with clear cell ovarian cancer: a systematic literature review	33
The putative oncogenic role of WDTC1 in colorectal cancer	31
LINC02418 upregulates EPHA2 by competitively sponging miR-372-3p to promote 5-Fu/DDP chemoresistance in colorectal cancer	28
miR-1304 targets KLK11 to regulate gastric cancer cell proliferation through the mTOR signaling pathway	27
Unravelling the distinct biological functions and potential therapeutic applications of TIMP2 in cancer	27
O-GlcNAcylation of RAB10 promotes hepatocellular carcinoma progression	26
The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model	26
Regulatory mechanisms of PFKFB2 in glycolysis and tumor metabolism: implications for cancer therapy	26
Identification of HCAR1 as a ferroptosis-related biomarker of gastric cancer based on a novel ferroptosis-related prognostic model and in vitro experiments	25
Cancer-testis non-coding RNA LEF1-AS1 regulates the nuclear translocation of PDCD5 and suppresses its interaction with p53 signaling: a novel target for immunotherapy in esophageal squamous cell carci	25
Prognostic value of circulating tumor DNA in different cancer types detected by ultra-low-pass whole-genome sequencing: a systematic review and patient-level survival data meta-analysis	24
miR-22 promotes immunosuppression via activating JAK/STAT3 signaling in cutaneous squamous cell carcinoma	24
Correction to: Triple-negative breast cancer molecular subtypes and potential detection targets for biological therapy indications	24
Longitudinal single-cell RNA model aids prediction of EGFR-TKI resistance	24
Redefining pancreatic cancer management with tumor-agnostic precision medicine	22
LncRNA LINC02253 activates KRT18/MAPK/ERK pathway by mediating N6-methyladenosine modification of KRT18 mRNA in gastric cancer	22
Ehm2 transcript variant 1 inhibits breast cancer progression and increases E-cadherin stability	21
Editor-in-Chief’s Note—Thank you to Reviewers	20
Epidemiological evidence for associations between variants in microRNA and cancer risk	19
Association between new plasma inflammatory markers and risk of colorectal neoplasms in individuals over 50 years old	19
Intratumoral vitamin D signaling and lethal prostate cancer	19
Long non-coding RNA NRAV in the 12q24.31 risk locus drives gastric cancer development through glucose metabolism reprogramming	18

Long noncoding RNA XIST: a novel independent prognostic biomarker for patients with ABC-DLBCL receiving R-CHOP treatment	17
Human cytomegalovirus alters immune cell profile with potential implications for patient survival in head and neck cancer	17
Solamargine enhanced gefitinib antitumor effect via regulating MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway in non-small cell lung cancer	17
α5-nAChR/STAT3/CD47 axis contributed to nicotine-related lung adenocarcinoma progression and immune escape	16
LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism	16
SIAH1/CTR9 axis promotes the epithelial–mesenchymal transition of hepatocellular carcinoma	16
Machine learning based on biological context facilitates the identification of microvascular invasion in intrahepatic cholangiocarcinoma	15
Urinary glyphosate levels and association with mortality in the 2013–16 National Health and Nutrition Examination Survey	15
Antibody–drug conjugates in breast cancer	15
Establishing a new-onset diabetes-related metabolism signature for predicting the prognosis and immune landscape in pancreatic cancer	15
miR-3154 promotes hepatocellular carcinoma progression via suppressing HNF4α	15
DUT enhances drug resistance to proteasome inhibitors via promoting mitochondrial function in multiple myeloma	14
MPZL1 upregulation promotes tumor metastasis and correlates with unfavorable prognosis in non-small cell lung cancer	14
ITGA2 as a prognostic factor of glioma promotes GSCs invasion and EMT by activating STAT3 phosphorylation	13
Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells	13
PPM1G promotes the progression of lung adenocarcinoma by inhibiting p38 activation via dephosphorylation of MEK6	13
Copine 1 predicts poor clinical outcomes by promoting M2 macrophage activation in ovarian cancer	13
Prognostic value of exosomal noncoding RNA in hepatocellular carcinoma: a meta-analysis	13
The impact of reproductive factors on breast tumor and normal-adjacent tissue immune profile from menarche to menopause	13
SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer	13
SLC38A6, regulated by EP300-mediated modifications of H3K27ac, promotes cell proliferation, glutamine metabolism and mitochondrial respiration in hepatocellular carcinoma	13
Germline alteration analysis reveals EPHB4R91H mutation as a key player in multiple primary lung tumors	13
From precursor to cancer: decoding the intrinsic and extrinsic pathways of pancreatic intraepithelial neoplasia progression	12
Genetic variants in glycosylation pathways are associated with colorectal cancer risk	12
Immune-related genes for the prediction of response to imatinib therapy in chronic myeloid leukemia	12
Outcome of clinical experience of introducing a patient with secondary systemic AL-amyloidosis associated with multiple myeloma	12
CYR61 confers chemoresistance by upregulating survivin expression in triple-negative breast cancer	12
MALAT1 regulates network of microRNA-15a/16–VEGFA to promote tumorigenesis and angiogenesis in multiple myeloma	12
BRAF V600E-induced distinct DNA damage response defines the therapeutic potential of p53 activation for TP53 wild-type colorectal cancer	12
SMARCA4/BRG1 deficiency induces a targetable dependence on oxidative phosphorylation in clear cell renal cell carcinoma	11
Sevoflurane inhibits lung cancer development by promoting FUS1 transcription via downregulating IRF6	11
Actinomycin D synergizes with Doxorubicin in triple-negative breast cancer by inducing P53-dependent cell apoptosis	11
Elevated expression of the membrane-anchored serine protease TMPRSS11E in NSCLC progression	11
MAPK3 modulates enhancer–promoter interactions of SKAP2 in acute myeloid leukemia	11
AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer	11
LncRNA-encoded peptide LRRC75A-AS1-ORF3 suppresses anti-tumor immunity in colorectal cancer through mitophagy-mediated attenuation of cGAS-STING signaling	11
SSH1 promotes progression of intrahepatic cholangiocarcinoma via p38 MAPK-CXCL8 axis	11
CacyBP promotes the development of lung adenocarcinoma by regulating OTUD5	11
Cancer-associated fibroblasts promote cancer stemness by inducing expression of the chromatin-modifying protein CBX4 in squamous cell carcinoma	10
Copper in colorectal cancer patients: a systematic review and meta-analysis	10
m6A-modified circASXL1 promotes proliferation and migration of ovarian cancer through the miR-320d/RACGAP1 axis	10
Suppressing the activation of protein kinase A as a DNA damage-independent mechanistic lead for dihydromethysticin prophylaxis of NNK-induced lung carcinogenesis	10
Somatic p53 mutations that are markedly overrepresented in lung cancer confer resistance to reactive oxygen species-induced cell death	10
E3 ubiquitin ligase RNF148 functions as an oncogene in colorectal cancer by ubiquitination-mediated degradation of CHAC2	10
Macrophage migration inhibitory factor as a prognostic biomarker in multiple myeloma: clinical significance and in vitro effects	10
Comparison of radiation-related cancer risks from the atomic bomb survivors with studies of pediatric medical radiation exposure	10
Dietary phytoestrogen intake and ovarian cancer risk: a prospective study in the prostate, lung, colorectal and ovarian (PLCO) cohort	10
LncRNA CCAT1 participates in pancreatic ductal adenocarcinoma progression by forming a positive feedback loop with c-Myc	10
Correction to: p62/SQSTM1 interacts with vimentin to enhance breast cancer metastasis	10
Expression profile of Claudins 3, 4, and 7 in breast tumors and its correlation with clinicopathological features	10

A polymorphic variant in telomere maintenance is associated with worrisome features and high-risk stigmata development in IPMNs	10
LncRNAs act as modulators of macrophages within the tumor microenvironment	9
Pan-cancer analysis of G6PD carcinogenesis in human tumors	9
Stem cells, Notch-1 signaling, and oxidative stress: a hellish trio in cancer development and progression within the airways. Is there a role for natural compounds?	9
NamiRNA-enhancer network of miR-492 activates the NR2C1-TGF-β/Smad3 pathway to promote epithelial-mesenchymal transition of pancreatic cancer	9
Tumor-associated astrocytes inhibit tumor cell apoptosis through TNF-α–TNF receptor 2–NF-κB pathway in lung cancer brain metastasis	9
ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment	9
The influence of homologous recombination repair on temozolomide chemosensitivity in gliomas	8
Associations of prediagnostic serum liver enzyme levels with lung cancer risk in predominantly low-income African and European Americans	8
Triple-negative breast cancer molecular subtypes and potential detection targets for biological therapy indications	8
Targeted sequencing and functional interrogation identified novel variant at 12q14.2 associated with risk of ovarian cancer in Han Chinese women	8
BRINP3 promotes lung adenocarcinoma by enhancing CLOCK-mediated transcriptional regulation of CRYZL1 and activating the AKT pathway	8
Adverse events and recent advances in CAR-T-cell therapy	8
CCL18 promotes migration and invasion of multiple myeloma cells and is associated with poor prognosis	8
Bipolar high-frequency electric welding in radical resection of frontal sinus tumors	8
Editor-In-Chief’s Editorial 2022 January Issue 43:1	8
Overview and future studies of potential hereditary effects of parental exposure to atomic bomb radiation on their offspring	8
Chemopreventive efficacy of silibinin against basal cell carcinoma growth and progression in UVB-irradiated Ptch+/– mice	8
Thymoquinone inhibits lung cancer stem cell properties via triggering YAP degradation	8
Hepatitis B virus X protein promotes hepatocarcinogenesis via the activation of HMGA2/STC2 signaling to counteract oxidative stress-induced cell death	8
Olfactomedin 4 promotes gastric cancer cell G2/M progression and serves as a therapeutic target in gastric adenocarcinoma	8
Integrative analysis of enrichment and prognostic value of ferroptosis-related genes and pathways in multiple myeloma	8
Maternal soybean genistein on prevention of later-life breast cancer through inherited epigenetic regulations	7
miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization	7
Plasma thioredoxin reductase: a potential diagnostic biomarker for gastric cancer	7
Dual activation of autophagy and mTOR by TFE3 fusions promotes tumorigenesis in rearranged renal cell carcinoma	7
Morphology dynamics in intestinal crypt during postnatal development affect age-dependent susceptibility to radiation-induced intestinal tumorigenesis in Apc Min/+ mice	7
SNCA inhibits epithelial–mesenchymal transition and correlates to favorable prognosis of breast cancer	7
CRL4DCAF4 E3 ligase-mediated degradation of MEN1 transcriptionally reactivates hTERT to sustain immortalization in colorectal cancer cells	7
TMEM16A inhibits autophagy and promotes the invasion of hypopharyngeal squamous cell carcinoma through mTOR pathway	7
HS-10296 (almonertinib) enhances radiosensitivity in EGFR-mutant nonsmall cell lung cancer (including T790M) through inhibition of EGFR downstream signaling and DNA damage repair	7
CDK12 is a promising therapeutic target for the transcription cycle and DNA damage response in metastatic osteosarcoma	7
Mechanisms of tumor-associated macrophages promoting tumor immune escape	7
Symposium report—ethical and social considerations regarding return of secondary findings in atomic bomb survivors	7
LncRNA UCA1 promotes vasculogenic mimicry by targeting miR-1-3p in gastric cancer	7
Call for Applications	6
Efficacy of depatuxizumab mafodotin (ABT-414) in preclinical models of head and neck cancer	6
The ubiquitin E3 ligase MDM2 induces chemoresistance in colorectal cancer by degradation of ING3	6
Targeting cyclin-dependent kinase 7—association between CDK7 and pMED1 expression in prostate cancer tissue	6
miR-424-3p promotes metastasis of hepatocellular carcinoma via targeting the SRF-STAT1/2 axis	6
Prognostic microRNA signature for estimating survival in patients with hepatocellular carcinoma	6
Identification and prioritization of tumour-associated antigens for immunotherapeutic and diagnostic capacity in epithelial ovarian cancer: a systematic literature review	6
Asbestos burden in lungs of mesothelioma patients with pleural plaques, lung fibrosis and/or ferruginous bodies at histology: a postmortem SEM-EDS study	6
HOXA10 promote pancreatic cancer progression via directly activating canonical NF-κB signaling pathway	6
Emerging evidence on the role of breast microbiota on the development of breast cancer in high-risk patients	6
Construction and testing of a risk prediction classifier for cardia carcinoma	6
Urinary biomarkers for the detection of ovarian cancer: a systematic review	6
Aqueous extracts of Ocimum gratissimum mitigate colitis and protect against AOM/DSS-induced colorectal cancer in mice	5
Wild-type p53 suppresses formin-binding protein-17 (FBP17) to reduce invasion	5
MIF/NR3C2 axis regulates glucose metabolism reprogramming in pancreatic cancer through MAPK–ERK and AP-1 pathways	5
Mutational signatures and increased retrotransposon insertions in xeroderma pigmentosum variant skin tumors	5
The HPV16 E6, E7/miR-23b-3p/ICAT signaling axis promotes proliferation, migration, invasion and EMT of cervical cancer cells	5
Genomic and transcriptomic significance of multiple primary lung cancers detected by next-generation sequencing in clinical settings	5
Long non-coding RNA KB-1460A1.5 promotes ferroptosis by inhibiting mTOR/SREBP-1/SCD1-mediated polyunsaturated fatty acid desaturation in glioma	5
Integrative functional screen of genomic loci uncovers CCND2 and its genetic regulatory mechanism in colorectal cancer development	5
Combinatory lung tumor inhibition by myo-inositol and iloprost/rapamycin: association with immunomodulation	5
Human papillomavirus (HPV) DNA methylation changes in HPV-associated head and neck cancer	5
Cancer-associated fibroblasts-derived exosome-mediated transfer of miR-345-5p promotes the progression of colorectal cancer by targeting CDKN1A	5
Transposable elements alter gene expression and may impact response to cisplatin therapy in ovarian cancer	5
miR-4461 inhibits liver cancer stem cells expansion and chemoresistance via regulating SIRT1	5
GPS2 confers l-asparaginase resistance in acute lymphoblastic leukemia cells through ATF4/ASNS axis	5
Recent evolution of risk analyses in atomic bomb survivor studies: new methods and applications	5
The anaphase-promoting complex/cyclosome co-activator, Cdh1, is a novel target of human papillomavirus 16 E7 oncoprotein in cervical oncogenesis	5
Genome-wide identification of aberrant alternative splicing and RNA-binding protein regulators in acute myeloid leukaemia which may contribute to immune microenvironment remodelling	5
The evolving role for surgery in pancreatic cancer	5
Exosomal microRNA-23b-3p promotes tumor angiogenesis and metastasis by targeting PTEN in salivary adenoid cystic carcinoma	5
Dysregulation of HNF1B/Clusterin axis enhances disease progression in a highly aggressive subset of pancreatic cancer patients	5
Intratumoral microbiota: new frontiers in tumor immunity	5
CircCDK17 promotes the proliferation and metastasis of ovarian cancer cells by sponging miR-22-3p to regulate CD147 expression	5
An update on the formation in tobacco, toxicity and carcinogenicity of Nʹ-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone	5
Eight decades of research on the long-term health effects of radiation in atomic bomb survivors and their offspring	5
Utilizing the Life Span Study data in NASA astronaut cancer risk assessment	5
Inhibition of phospholipase D1 reduces pancreatic carcinogenesis in mice partly through a FAK-dependent mechanism	5
Colorectal cancer cells with high metastatic potential drive metastasis by transmitting exosomal miR-20a-3p through modulating NF1/MAPK pathway	4
CD133-containing microvesicles promote cancer progression by inducing M2-like tumor-associated macrophage polarization in the tumor microenvironment of colorectal cancer	4
FZD6 promotes 5-fluorouracil resistance through inhibiting pyroptosis in colorectal cancer	4
The ubiquitin ligase STUB1 suppresses tumorigenesis of renal cell carcinomas through regulating YTHDF1 stability	4
Correction to: Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer	4
Inhibition of lysosomal acid β-glucosidase induces cell apoptosis via impairing mitochondrial clearance in pancreatic cancer	4
Type-2 cGMP-dependent protein kinase suppresses proliferation and carcinogenesis in the colon epithelium	4

Retraction of: Genetic and clinical characteristics of BRCA-associated hereditary breast cancer in the West region of Kazakhstan	4
LncRNA CASC19 promotes gastric cancer progression through preventing CREB1 protein ubiquitin/proteasome-dependent degradation	4
Ginseng mediates its anticancer activity by inhibiting the expression of DNMTs and reactivating methylation-silenced genes in colorectal cancer	4
Editor-in-Chief’s Note—Thank you to Reviewers	4
Genomic landscape of chemical-induced lung tumors under Nrf2 different expression levels	4
NFE2L3 promotes tumor progression and predicts a poor prognosis of bladder cancer	4
Enhancing carboplatin sensitivity in ovarian cancer cells by blocking the mercapturic acid pathway transporter	4
TRIM14 suppressed the progression of NSCLC via hexosamine biosynthesis pathway	4
Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression	4
Retraction of: Pro-angiogenesis action of arsenic and its reversal by selenium-derived compounds	4
Understanding the role of dopamine in cancer: past, present and future	4
Advanced glycation end products promote the progression of endometrial cancer via activating the RAGE/CHKA/PI3K/AKT signaling pathway	4
Reactions of [13C]-labelled tobacco smoke with DNA to generate selected adducts formed without metabolic activation	4
Editor-in-Chief’s Note—Thank you to Reviewers	4
tRF-29-79 regulates lung adenocarcinoma progression through mediating glutamine transporter SLC1A5	4
Co-targeting KRASG12D and the HER family is efficacious in colorectal cancer	4
Correction to: Epigenetic silencing of O6 -methylguanine DNA methyltransferase gene in NiS-transformed cells	4
Pathological point of view on the atomic bomb-related solid cancers	4
ETS1 deficiency in macrophages suppresses colorectal cancer progression by reducing the F4/80+TIM4+ macrophage population	4
ACSL4: a double-edged sword target in multiple myeloma, promotes cell proliferation and sensitizes cell to ferroptosis	4
The role of interleukin 17 in cancer: a systematic review	4
Polo-like kinase 4 (PLK4) as a therapeutic target in breast cancer	3
Andrew Zloza, MD, PhD (1978–2024)	3
Amlodipine, an L-type Ca2+ channel inhibitor, regulates release of extracellular vesicles from tumor cells	3
Sitravatinib combined with PD-1 blockade enhances cytotoxic T-cell infiltration by M2 to M1 tumor macrophage repolarization in esophageal adenocarcinoma	3
LncRNA MEG3 suppresses prostate cancer progression by mediating macrophage polarization via the miR-148a-3p/ARRDC3 signaling axis	3
Commentary: Role and communications of cancer hazard determinations	3
Retracted: Genetic and clinical characteristics of BRCA-associated hereditary breast cancer in the West region of Kazakhstan	3
TERT and BRAF V600E mutations in thyroid cancer of World Trade Center Responders	3
Increased acrolein–DNA adducts in buccal brushings of e-cigarette users	3
Splicing transcriptome-wide association study to identify splicing events for pancreatic cancer risk	3
Risk of clonal hematopoiesis in families exposed to radiation following the Chornobyl accident	3
Detection of DNA adducts derived from the tobacco carcinogens, benzo[a]pyrene and dibenzo[def,p]chrysene in human oral buccal cells	3
Age-related macrophage alterations are associated with carcinogenesis of colorectal cancer	3
The presence of intratumoral Porphyromonas gingivalis correlates with a previously defined pancreatic adenocarcinoma, immune cell expression phenotype and with tumor resident, adaptive immune r	3
Triterpenoid ursolic acid regulates the environmental carcinogen benzo[a]pyrene-driven epigenetic and metabolic alterations in SKH-1 hairless mice for skin cancer interception	3
Constitutive epidermal expression of osteopontin in osteopontin-null mice restores ultraviolet B-induced cutaneous squamous cell carcinomas to wild-type levels	3
The BET inhibitor GNE-987 effectively induces anti-cancer effects in T-cell acute lymphoblastic leukemia by targeting enhancer regulated genes	3
Dehydroabietylamine exerts antitumor effects by affecting nucleotide metabolism in gastric cancer	3
Eighty years of cancer research after the atomic bombings of Hiroshima and Nagasaki	3
LncRNA CARD8-AS1 suppresses lung adenocarcinoma progression by enhancing TRIM25-mediated ubiquitination of TXNRD1	3
ARID1Amutations in cancer development: mechanism and therapy	3
Correction to: Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation	3
Effect of vitamin E δ-tocotrienol and aspirin on Wnt signaling in human colon cancer stem cells and in adenoma development in APCmin/+ mice	3
Smoking and risk of colorectal cancer according to KRAS and BRAF mutation status in a Japanese prospective Study	3