Carcinogenesis

Article	Citations
Editor-In-Chief’s Editorial 2023	60
Intermittent administration of tacrolimus enhances 
anti-tumor immunity in melanoma-bearing mice	36
Identification of biomarkers for the diagnosis and targets for therapy in patients with clear cell ovarian cancer: a systematic literature review	35
miR-1304 targets KLK11 to regulate gastric cancer cell proliferation through the mTOR signaling pathway	31
Regulatory mechanisms of PFKFB2 in glycolysis and tumor metabolism: implications for cancer therapy	29
Genomic profile of radiation-induced early-onset mouse B-cell lymphoma recapitulates features of Philadelphia chromosome-like acute lymphoblastic leukemia in humans	27
LINC02418 upregulates EPHA2 by competitively sponging miR-372-3p to promote 5-Fu/DDP chemoresistance in colorectal cancer	25
Unravelling the distinct biological functions and potential therapeutic applications of TIMP2 in cancer	25
O-GlcNAcylation of RAB10 promotes hepatocellular carcinoma progression	25
The putative oncogenic role of WDTC1 in colorectal cancer	25
The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model	24
Cancer-testis non-coding RNA LEF1-AS1 regulates the nuclear translocation of PDCD5 and suppresses its interaction with p53 signaling: a novel target for immunotherapy in esophageal squamous cell carci	24
miR-22 promotes immunosuppression via activating JAK/STAT3 signaling in cutaneous squamous cell carcinoma	23
Redefining pancreatic cancer management with tumor-agnostic precision medicine	23
The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes	23
Prognostic value of circulating tumor DNA in different cancer types detected by ultra-low-pass whole-genome sequencing: a systematic review and patient-level survival data meta-analysis	22
Identification of HCAR1 as a ferroptosis-related biomarker of gastric cancer based on a novel ferroptosis-related prognostic model and in vitro experiments	22
Longitudinal single-cell RNA model aids prediction of EGFR-TKI resistance	21
LncRNA LINC02253 activates KRT18/MAPK/ERK pathway by mediating N6-methyladenosine modification of KRT18 mRNA in gastric cancer	21
Ehm2 transcript variant 1 inhibits breast cancer progression and increases E-cadherin stability	20
Editor-in-Chief’s Note—Thank you to Reviewers	20
LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism	19
Epidemiological evidence for associations between variants in microRNA and cancer risk	19
SIAH1/CTR9 axis promotes the epithelial–mesenchymal transition of hepatocellular carcinoma	18
MiR-145 modulates the radiosensitivity of non-small cell lung cancer cells by suppression of TMOD3	18

miR-3154 promotes hepatocellular carcinoma progression via suppressing HNF4α	18
Association between new plasma inflammatory markers and risk of colorectal neoplasms in individuals over 50 years old	18
Intratumoral vitamin D signaling and lethal prostate cancer	17
α5-nAChR/STAT3/CD47 axis contributed to nicotine-related lung adenocarcinoma progression and immune escape	16
Characterization of adductomic totality of NNK, (R)-NNAL and (S)-NNAL in A/J mice, and their correlations with distinct lung carcinogenicity	16
Long noncoding RNA XIST: a novel independent prognostic biomarker for patients with ABC-DLBCL receiving R-CHOP treatment	16
Machine learning based on biological context facilitates the identification of microvascular invasion in intrahepatic cholangiocarcinoma	16
Solamargine enhanced gefitinib antitumor effect via regulating MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway in non-small cell lung cancer	15
Antibody–drug conjugates in breast cancer	15
Long non-coding RNA NRAV in the 12q24.31 risk locus drives gastric cancer development through glucose metabolism reprogramming	15
SLC38A6, regulated by EP300-mediated modifications of H3K27ac, promotes cell proliferation, glutamine metabolism and mitochondrial respiration in hepatocellular carcinoma	15
Human cytomegalovirus alters immune cell profile with potential implications for patient survival in head and neck cancer	15
Urinary glyphosate levels and association with mortality in the 2013–16 National Health and Nutrition Examination Survey	15
Establishing a new-onset diabetes-related metabolism signature for predicting the prognosis and immune landscape in pancreatic cancer	14
Copine 1 predicts poor clinical outcomes by promoting M2 macrophage activation in ovarian cancer	14
DUT enhances drug resistance to proteasome inhibitors via promoting mitochondrial function in multiple myeloma	14
Prognostic value of exosomal noncoding RNA in hepatocellular carcinoma: a meta-analysis	14
PPM1G promotes the progression of lung adenocarcinoma by inhibiting p38 activation via dephosphorylation of MEK6	14
MPZL1 upregulation promotes tumor metastasis and correlates with unfavorable prognosis in non-small cell lung cancer	14
ITGA2 as a prognostic factor of glioma promotes GSCs invasion and EMT by activating STAT3 phosphorylation	14
Immune-related genes for the prediction of response to imatinib therapy in chronic myeloid leukemia	13
CYR61 confers chemoresistance by upregulating survivin expression in triple-negative breast cancer	13
Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells	13
Germline alteration analysis reveals EPHB4R91H mutation as a key player in multiple primary lung tumors	13
The impact of reproductive factors on breast tumor and normal-adjacent tissue immune profile from menarche to menopause	13
BRAF V600E-induced distinct DNA damage response defines the therapeutic potential of p53 activation for TP53 wild-type colorectal cancer	13
From precursor to cancer: decoding the intrinsic and extrinsic pathways of pancreatic intraepithelial neoplasia progression	12
SSH1 promotes progression of intrahepatic cholangiocarcinoma via p38 MAPK-CXCL8 axis	12
Outcome of clinical experience of introducing a patient with secondary systemic AL-amyloidosis associated with multiple myeloma	12
MALAT1 regulates network of microRNA-15a/16–VEGFA to promote tumorigenesis and angiogenesis in multiple myeloma	12
Actinomycin D synergizes with Doxorubicin in triple-negative breast cancer by inducing P53-dependent cell apoptosis	12
CacyBP promotes the development of lung adenocarcinoma by regulating OTUD5	11
Elevated expression of the membrane-anchored serine protease TMPRSS11E in NSCLC progression	11
SMARCA4/BRG1 deficiency induces a targetable dependence on oxidative phosphorylation in clear cell renal cell carcinoma	11
Cancer-associated fibroblasts promote cancer stemness by inducing expression of the chromatin-modifying protein CBX4 in squamous cell carcinoma	11
Copper in colorectal cancer patients: a systematic review and meta-analysis	11
Sevoflurane inhibits lung cancer development by promoting FUS1 transcription via downregulating IRF6	11
MAPK3 Modulates Enhancer-Promoter Interactions of SKAP2 in Acute Myeloid Leukemia	11
Macrophage migration inhibitory factor as a prognostic biomarker in multiple myeloma: clinical significance and in vitro effects	11
E3 ubiquitin ligase RNF148 functions as an oncogene in colorectal cancer by ubiquitination-mediated degradation of CHAC2	11
LncRNA CCAT1 participates in pancreatic ductal adenocarcinoma progression by forming a positive feedback loop with c-Myc	11
Genetic variants in glycosylation pathways are associated with colorectal cancer risk	11
AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer	11
Somatic p53 mutations that are markedly overrepresented in lung cancer confer resistance to reactive oxygen species-induced cell death	11
Expression profile of Claudins 3, 4, and 7 in breast tumors and its correlation with clinicopathological features	11
Correction to: p62/SQSTM1 interacts with vimentin to enhance breast cancer metastasis	11
Suppressing the activation of protein kinase A as a DNA damage-independent mechanistic lead for dihydromethysticin prophylaxis of NNK-induced lung carcinogenesis	10
NamiRNA-enhancer network of miR-492 activates the NR2C1-TGF-β/Smad3 pathway to promote epithelial-mesenchymal transition of pancreatic cancer	10
Comparison of radiation-related cancer risks from the atomic bomb survivors with studies of pediatric medical radiation exposure	10
LncRNAs act as modulators of macrophages within the tumor microenvironment	10

Pan-cancer analysis of G6PD carcinogenesis in human tumors	10
Stem cells, Notch-1 signaling, and oxidative stress: a hellish trio in cancer development and progression within the airways. Is there a role for natural compounds?	10
A polymorphic variant in telomere maintenance is associated with worrisome features and high-risk stigmata development in IPMNs	10
The miR-345-3p/PPP2CA signaling axis promotes proliferation and invasion of breast cancer cells	10
Dietary phytoestrogen intake and ovarian cancer risk: a prospective study in the prostate, lung, colorectal and ovarian (PLCO) cohort	10
Corrigendum to: A functional CNVR_3425.1 damping lincRNA FENDRR increases lifetime risk of lung cancer and COPD in Chinese	9
BRINP3 promotes lung adenocarcinoma by enhancing CLOCK-mediated transcriptional regulation of CRYZL1 and activating the AKT pathway	9
m6A-modified circASXL1 promotes proliferation and migration of ovarian cancer through the miR-320d/RACGAP1 axis	9
Associations of prediagnostic serum liver enzyme levels with lung cancer risk in predominantly low-income African and European Americans	9
Bipolar high-frequency electric welding in radical resection of frontal sinus tumors	9
Hepatitis B virus X protein promotes hepatocarcinogenesis via the activation of HMGA2/STC2 signaling to counteract oxidative stress-induced cell death	9
ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment	9
Editor-In-Chief’s Editorial 2022 January Issue 43:1	9
Modulation of the oral glucocorticoid system during black raspberry mediated oral cancer chemoprevention	9
Targeted sequencing and functional interrogation identified novel variant at 12q14.2 associated with risk of ovarian cancer in Han Chinese women	9
Olfactomedin 4 promotes gastric cancer cell G2/M progression and serves as a therapeutic target in gastric adenocarcinoma	8
Integrative analysis of enrichment and prognostic value of ferroptosis-related genes and pathways in multiple myeloma	8
CRL4DCAF4 E3 ligase-mediated degradation of MEN1 transcriptionally reactivates hTERT to sustain immortalization in colorectal cancer cells	8
Chemopreventive efficacy of silibinin against basal cell carcinoma growth and progression in UVB-irradiated Ptch+/– mice	8
Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers	8
Thymoquinone inhibits lung cancer stem cell properties via triggering YAP degradation	8
Triple-negative breast cancer molecular subtypes and potential detection targets for biological therapy indications	8
Overview and future studies of potential hereditary effects of parental exposure to atomic bomb radiation on their offspring	8
The influence of homologous recombination repair on temozolomide chemosensitivity in gliomas	8
Symposium report—ethical and social considerations regarding return of secondary findings in atomic bomb survivors	8
HS-10296 (Almonertinib) enhances radiosensitivity in EGFR-mutant NSCLC (including T790M) through inhibition of EGFR downstream signaling and DNA damage repair	7
Asbestos burden in lungs of mesothelioma patients with pleural plaques, lung fibrosis and/or ferruginous bodies at histology: a postmortem SEM-EDS study	7
Identification and prioritization of tumour-associated antigens for immunotherapeutic and diagnostic capacity in epithelial ovarian cancer: a systematic literature review	7
Efficacy of depatuxizumab mafodotin (ABT-414) in preclinical models of head and neck cancer	7
Plasma thioredoxin reductase: a potential diagnostic biomarker for gastric cancer	7
Maternal soybean genistein on prevention of later-life breast cancer through inherited epigenetic regulations	7
Mechanisms of tumor-associated macrophages promoting tumor immune escape	7
miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization	7
Call for Applications	7
SNCA inhibits epithelial–mesenchymal transition and correlates to favorable prognosis of breast cancer	7
CCL18 promotes migration and invasion of multiple myeloma cells and is associated with poor prognosis	7
LncRNA UCA1 promotes vasculogenic mimicry by targeting miR-1-3p in gastric cancer	7
Morphology dynamics in intestinal crypt during postnatal development affect age-dependent susceptibility to radiation-induced intestinal tumorigenesis in Apc Min/+ mice	7
HOXA10 promote pancreatic cancer progression via directly activating canonical NF-κB signaling pathway	7
Urinary biomarkers for the detection of ovarian cancer: a systematic review	7
CDK12 is a promising therapeutic target for the transcription cycle and DNA damage response in metastatic osteosarcoma	7
TMEM16A inhibits autophagy and promotes the invasion of hypopharyngeal squamous cell carcinoma through mTOR pathway	7
Emerging evidence on the role of breast microbiota on the development of breast cancer in high-risk patients	6
Genome-wide identification of aberrant alternative splicing and RNA-binding protein regulators in acute myeloid leukaemia which may contribute to immune microenvironment remodelling	6
Inhibition of phospholipase D1 reduces pancreatic carcinogenesis in mice partly through a FAK-dependent mechanism	6
Combinatory lung tumor inhibition by myo-inositol and iloprost/rapamycin: association with immunomodulation	6
Prognostic microRNA signature for estimating survival in patients with hepatocellular carcinoma	6
miR-424-3p promotes metastasis of hepatocellular carcinoma via targeting the SRF-STAT1/2 axis	6
The ubiquitin E3 ligase MDM2 induces chemoresistance in colorectal cancer by degradation of ING3	6
Integrative functional screen of genomic loci uncovers CCND2 and its genetic regulatory mechanism in colorectal cancer development	6
The anaphase-promoting complex/cyclosome co-activator, Cdh1, is a novel target of human papillomavirus 16 E7 oncoprotein in cervical oncogenesis	6
Construction and testing of a risk prediction classifier for cardia carcinoma	6
Targeting cyclin-dependent kinase 7—association between CDK7 and pMED1 expression in prostate cancer tissue	6
GPS2 confers l-asparaginase resistance in acute lymphoblastic leukemia cells through ATF4/ASNS axis	6
Genomic and transcriptomic significance of multiple primary lung cancers detected by next-generation sequencing in clinical settings	6
Gastric tumorigenesis induced by combining Helicobacter pylori infection and chronic alcohol through IL-10 inhibition	5
Recent evolution of risk analyses in atomic bomb survivor studies: new methods and applications	5
Aspirin suppresses breast cancer metastasis to lung by targeting anoikis resistance	5
The evolving role for surgery in pancreatic cancer	5
miR-4461 inhibits liver cancer stem cells expansion and chemoresistance via regulating SIRT1	5
An update on the formation in tobacco, toxicity and carcinogenicity of Nʹ-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone	5
Long non-coding RNA KB-1460A1.5 promotes ferroptosis by inhibiting mTOR/SREBP-1/SCD1-mediated polyunsaturated fatty acid desaturation in glioma	5
The HPV16 E6, E7/miR-23b-3p/ICAT signaling axis promotes proliferation, migration, invasion and EMT of cervical cancer cells	5
CircCDK17 promotes the proliferation and metastasis of ovarian cancer cells by sponging miR-22-3p to regulate CD147 expression	5
Dysregulation of HNF1B/Clusterin axis enhances disease progression in a highly aggressive subset of pancreatic cancer patients	5
Eight decades of research on the long-term health effects of radiation in atomic bomb survivors and their offspring	5
Aqueous extracts of Ocimum gratissimum mitigate colitis and protect against AOM/DSS-induced colorectal cancer in mice	5
Transposable elements alter gene expression and may impact response to cisplatin therapy in ovarian cancer	5
Intratumoral microbiota: new frontiers in tumor immunity	5
CD133-containing microvesicles promote cancer progression by inducing M2-like tumor-associated macrophage polarization in the tumor microenvironment of colorectal cancer	4
Colorectal cancer cells with high metastatic potential drive metastasis by transmitting exosomal miR-20a-3p through modulating NF1/MAPK pathway	4
Human papillomavirus (HPV) DNA methylation changes in HPV-associated head and neck cancer	4
LncRNA CASC19 promotes gastric cancer progression through preventing CREB1 protein ubiquitin/proteasome-dependent degradation	4
Retraction of: Genetic and clinical characteristics of BRCA-associated hereditary breast cancer in the West region of Kazakhstan	4
Sitravatinib combined with PD-1 blockade enhances cytotoxic T-cell infiltration by M2 to M1 tumor macrophage repolarization in esophageal adenocarcinoma	4
Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression	4
Editor-in-Chief’s Note—Thank you to Reviewers	4
Genomic landscape of chemical-induced lung tumors under Nrf2 different expression levels	4
The role of interleukin 17 in cancer: a systematic review	4
Ginseng mediates its anticancer activity by inhibiting the expression of DNMTs and reactivating methylation-silenced genes in colorectal cancer	4

Cancer-associated fibroblasts-derived exosome-mediated transfer of miR-345-5p promotes the progression of colorectal cancer by targeting CDKN1A	4
Mutational signatures and increased retrotransposon insertions in xeroderma pigmentosum variant skin tumors	4
Wild-type p53 suppresses formin-binding protein-17 (FBP17) to reduce invasion	4
ETS1 deficiency in macrophages suppresses colorectal cancer progression by reducing the F4/80+TIM4+ macrophage population	4
Understanding the role of dopamine in cancer: past, present and future	4
FZD6 promotes 5-fluorouracil resistance through inhibiting pyroptosis in colorectal cancer	4
Editor-in-Chief’s Note—Thank you to Reviewers	4
ACSL4: a double-edged sword target in multiple myeloma, promotes cell proliferation and sensitizes cell to ferroptosis	4
Reactions of [13C]-labelled tobacco smoke with DNA to generate selected adducts formed without metabolic activation	4
MIF/NR3C2 axis regulates glucose metabolism reprogramming in pancreatic cancer through MAPK–ERK and AP-1 pathways	4
Exosomal microRNA-23b-3p promotes tumor angiogenesis and metastasis by targeting PTEN in salivary adenoid cystic carcinoma	4
Advanced glycation end products promote the progression of endometrial cancer via activating the RAGE/CHKA/PI3K/AKT signaling pathway	4
Co-targeting KRASG12D and the HER family is efficacious in colorectal cancer	4
Inhibition of lysosomal acid β-glucosidase induces cell apoptosis via impairing mitochondrial clearance in pancreatic cancer	4
Correction to: Epigenetic silencing of O6 -methylguanine DNA methyltransferase gene in NiS-transformed cells	4
Retraction of: Pro-angiogenesis action of arsenic and its reversal by selenium-derived compounds	4
Splicing transcriptome-wide association study to identify splicing events for pancreatic cancer risk	3
The presence of intratumoral Porphyromonas gingivalis correlates with a previously defined pancreatic adenocarcinoma, immune cell expression phenotype and with tumor resident, adaptive immune r	3
LncRNA MEG3 suppresses prostate cancer progression by mediating macrophage polarization via the miR-148a-3p/ARRDC3 signaling axis	3
Detection of DNA adducts derived from the tobacco carcinogens, benzo[a]pyrene and dibenzo[def,p]chrysene in human oral buccal cells	3
tRF-29-79 regulates lung adenocarcinoma progression through mediating glutamine transporter SLC1A5	3
Enhancing carboplatin sensitivity in ovarian cancer cells by blocking the mercapturic acid pathway transporter	3
Eighty years of cancer research after the atomic bombings of Hiroshima and Nagasaki	3
TERT and BRAF V600E mutations in thyroid cancer of World Trade Center Responders	3
Triterpenoid ursolic acid regulates the environmental carcinogen benzo[a]pyrene-driven epigenetic and metabolic alterations in SKH-1 hairless mice for skin cancer interception	3
Polo-like Kinase 4 (PLK4) as a Therapeutic Target in Breast Cancer	3
Transcription phenotype of circulating tumor cells in non-metastatic breast cancer	3
Correction to: Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer	3
Risk of clonal hematopoiesis in families exposed to radiation following the Chornobyl accident	3
Type-2 cGMP-dependent protein kinase suppresses proliferation and carcinogenesis in the colon epithelium	3
TRIM14 suppressed the progression of NSCLC via hexosamine biosynthesis pathway	3
NFE2L3 promotes tumor progression and predicts a poor prognosis of bladder cancer	3
USP53 activated by H3K27 acetylation regulates cell viability, apoptosis and metabolism in esophageal carcinoma via the AMPK signaling pathway	3
Constitutive Epidermal Expression of Osteopontin in Osteopontin-Null Mice Restores Ultraviolet B-Induced Cutaneous Squamous Cell Carcinomas to Wild-Type Levels	3
Effect of vitamin E δ-tocotrienol and aspirin on Wnt signaling in human colon cancer stem cells and in adenoma development in APCmin/+ mice	3
The BET inhibitor GNE-987 effectively induces anti-cancer effects in T-cell acute lymphoblastic leukemia by targeting enhancer regulated genes	3
ARID1Amutations in cancer development: mechanism and therapy	3
Commentary: Role and communications of cancer hazard determinations	3
Andrew Zloza, MD, PhD (1978–2024)	3
Age-related macrophage alterations are associated with carcinogenesis of colorectal cancer	3
Amlodipine, an L-type Ca2+ channel inhibitor, regulates release of extracellular vesicles from tumor cells	3
LncRNA CARD8-AS1 suppresses lung adenocarcinoma progression by enhancing TRIM25-mediated ubiquitination of TXNRD1	3
The ubiquitin ligase STUB1 suppresses tumorigenesis of renal cell carcinomas through regulating YTHDF1 stability	3
Dehydroabietylamine exerts antitumor effects by affecting nucleotide metabolism in gastric cancer	3
Increased acrolein–DNA adducts in buccal brushings of e-cigarette users	3
Smoking and risk of colorectal cancer according to KRAS and BRAF mutation status in a Japanese prospective Study	3