Carcinogenesis

Article	Citations
Editor-In-Chief’s Editorial 2023	52
Regulatory mechanisms of PFKFB2 in glycolysis and tumor metabolism: implications for cancer therapy	41
miR-1304 targets KLK11 to regulate gastric cancer cell proliferation through the mTOR signaling pathway	40
LINC02418 upregulates EPHA2 by competitively sponging miR-372-3p to promote 5-Fu/DDP chemoresistance in colorectal cancer	32
Longitudinal single-cell RNA model aids prediction of EGFR-TKI resistance	31
Correction to: Triple-negative breast cancer molecular subtypes and potential detection targets for biological therapy indications	30
miR-22 promotes immunosuppression via activating JAK/STAT3 signaling in cutaneous squamous cell carcinoma	27
Expression of Concern: The promoting effects of hsa_circ_0050102 in pancreatic cancer and the molecular mechanism by targeting miR-1182/NPSR1	26
Identification of HCAR1 as a ferroptosis-related biomarker of gastric cancer based on a novel ferroptosis-related prognostic model and in vitro experiments	24
Cancer-testis non-coding RNA LEF1-AS1 regulates the nuclear translocation of PDCD5 and suppresses its interaction with p53 signaling: a novel target for immunotherapy in esophageal squamous cell carci	23
The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model	23
O-GlcNAcylation of RAB10 promotes hepatocellular carcinoma progression	22
Redefining pancreatic cancer management with tumor-agnostic precision medicine	21
Editor-in-Chief’s Note—Thank you to Reviewers	20
Prognostic value of circulating tumor DNA in different cancer types detected by ultra-low-pass whole-genome sequencing: a systematic review and patient-level survival data meta-analysis	20
α5-nAChR/STAT3/CD47 axis contributed to nicotine-related lung adenocarcinoma progression and immune escape	19
Long non-coding RNA NRAV in the 12q24.31 risk locus drives gastric cancer development through glucose metabolism reprogramming	19
Association between new plasma inflammatory markers and risk of colorectal neoplasms in individuals over 50 years old	19
Ehm2 transcript variant 1 inhibits breast cancer progression and increases E-cadherin stability	18
Machine learning based on biological context facilitates the identification of microvascular invasion in intrahepatic cholangiocarcinoma	17
LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism	17
miR-3154 promotes hepatocellular carcinoma progression via suppressing HNF4α	17
SIAH1/CTR9 axis promotes the epithelial–mesenchymal transition of hepatocellular carcinoma	16
Solamargine enhanced gefitinib antitumor effect via regulating MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway in non-small cell lung cancer	16
Intratumoral vitamin D signaling and lethal prostate cancer	16

Establishing a new-onset diabetes-related metabolism signature for predicting the prognosis and immune landscape in pancreatic cancer	16
Long noncoding RNA XIST: a novel independent prognostic biomarker for patients with ABC-DLBCL receiving R-CHOP treatment	16
The tumour microenvironment in paediatric rhabdomyosarcomas: a systematic review	16
ITGA2 as a prognostic factor of glioma promotes GSCs invasion and EMT by activating STAT3 phosphorylation	15
Copine 1 predicts poor clinical outcomes by promoting M2 macrophage activation in ovarian cancer	15
DUT enhances drug resistance to proteasome inhibitors via promoting mitochondrial function in multiple myeloma	15
PPM1G promotes the progression of lung adenocarcinoma by inhibiting p38 activation via dephosphorylation of MEK6	15
Genomic and transcriptomic characterization of gamma ray- and heavy-ion-induced precursor B-cell lymphomas in B6C3F1 mice: radiation-type-dependent interstitial chromosomal deletions at tumor-suppress	14
BRAF V600E-induced distinct DNA damage response defines the therapeutic potential of p53 activation for TP53 wild-type colorectal cancer	14
SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer	14
Antibody–drug conjugates in breast cancer	14
Genetic variants in glycosylation pathways are associated with colorectal cancer risk	14
Immune-related genes for the prediction of response to imatinib therapy in chronic myeloid leukemia	14
Urinary glyphosate levels and association with mortality in the 2013–16 National Health and Nutrition Examination Survey	14
Germline alteration analysis reveals EPHB4R91H mutation as a key player in multiple primary lung tumors	14
Outcome of clinical experience of introducing a patient with secondary systemic AL-amyloidosis associated with multiple myeloma	14
Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells	14
MALAT1 regulates network of microRNA-15a/16–VEGFA to promote tumorigenesis and angiogenesis in multiple myeloma	13
CYR61 confers chemoresistance by upregulating survivin expression in triple-negative breast cancer	13
The impact of reproductive factors on breast tumor and normal-adjacent tissue immune profile from menarche to menopause	13
Elevated expression of the membrane-anchored serine protease TMPRSS11E in NSCLC progression	12
From precursor to cancer: decoding the intrinsic and extrinsic pathways of pancreatic intraepithelial neoplasia progression	12
Actinomycin D synergizes with Doxorubicin in triple-negative breast cancer by inducing P53-dependent cell apoptosis	12
MAPK3 modulates enhancer–promoter interactions of SKAP2 in acute myeloid leukemia	12
SSH1 promotes progression of intrahepatic cholangiocarcinoma via p38 MAPK-CXCL8 axis	12
Characteristic genetic alterations associated with the partial deletion of chromosome 11 in mouse thymic lymphomas induced by high-linear energy transfer irradiation with carbon ions	11
AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer	11
LncRNA-encoded peptide LRRC75A-AS1-ORF3 suppresses anti-tumor immunity in colorectal cancer through mitophagy-mediated attenuation of cGAS-STING signaling	11
CacyBP promotes the development of lung adenocarcinoma by regulating OTUD5	11
Sevoflurane inhibits lung cancer development by promoting FUS1 transcription via downregulating IRF6	11
SMARCA4/BRG1 deficiency induces a targetable dependence on oxidative phosphorylation in clear cell renal cell carcinoma	11
Expression profile of Claudins 3, 4, and 7 in breast tumors and its correlation with clinicopathological features	10
m6A-modified circASXL1 promotes proliferation and migration of ovarian cancer through the miR-320d/RACGAP1 axis	10
ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment	10
Stem cells, Notch-1 signaling, and oxidative stress: a hellish trio in cancer development and progression within the airways. Is there a role for natural compounds?	10
LncRNA CCAT1 participates in pancreatic ductal adenocarcinoma progression by forming a positive feedback loop with c-Myc	10
Dietary phytoestrogen intake and ovarian cancer risk: a prospective study in the prostate, lung, colorectal and ovarian (PLCO) cohort	10
Correction to: Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-κB	10
Comparison of radiation-related cancer risks from the atomic bomb survivors with studies of pediatric medical radiation exposure	10
Correction to: p62/SQSTM1 interacts with vimentin to enhance breast cancer metastasis	10
Copper in colorectal cancer patients: a systematic review and meta-analysis	10
Tumor-associated astrocytes inhibit tumor cell apoptosis through TNF-α–TNF receptor 2–NF-κB pathway in lung cancer brain metastasis	10
Cancer-associated fibroblasts promote cancer stemness by inducing expression of the chromatin-modifying protein CBX4 in squamous cell carcinoma	10
E3 ubiquitin ligase RNF148 functions as an oncogene in colorectal cancer by ubiquitination-mediated degradation of CHAC2	9
BRINP3 promotes lung adenocarcinoma by enhancing CLOCK-mediated transcriptional regulation of CRYZL1 and activating the AKT pathway	9
Adverse events and recent advances in CAR-T-cell therapy	9
Pan-cancer analysis of G6PD carcinogenesis in human tumors	9
Somatic p53 mutations that are markedly overrepresented in lung cancer confer resistance to reactive oxygen species-induced cell death	9
Associations of prediagnostic serum liver enzyme levels with lung cancer risk in predominantly low-income African and European Americans	9
LncRNAs act as modulators of macrophages within the tumor microenvironment	9

Macrophage migration inhibitory factor as a prognostic biomarker in multiple myeloma: clinical significance and in vitro effects	9
Targeted sequencing and functional interrogation identified novel variant at 12q14.2 associated with risk of ovarian cancer in Han Chinese women	9
Overview and future studies of potential hereditary effects of parental exposure to atomic bomb radiation on their offspring	9
NamiRNA-enhancer network of miR-492 activates the NR2C1-TGF-β/Smad3 pathway to promote epithelial-mesenchymal transition of pancreatic cancer	9
Olfactomedin 4 promotes gastric cancer cell G2/M progression and serves as a therapeutic target in gastric adenocarcinoma	8
Symposium report—ethical and social considerations regarding return of secondary findings in atomic bomb survivors	8
The influence of homologous recombination repair on temozolomide chemosensitivity in gliomas	8
HS-10296 (almonertinib) enhances radiosensitivity in EGFR-mutant nonsmall cell lung cancer (including T790M) through inhibition of EGFR downstream signaling and DNA damage repair	8
Bipolar high-frequency electric welding in radical resection of frontal sinus tumors	8
Retraction: miR-720 inhibits tumor invasion and migration in breast cancer by targeting TWIST1	8
CCL18 promotes migration and invasion of multiple myeloma cells and is associated with poor prognosis	8
Thymoquinone inhibits lung cancer stem cell properties via triggering YAP degradation	8
CRL4DCAF4 E3 ligase-mediated degradation of MEN1 transcriptionally reactivates hTERT to sustain immortalization in colorectal cancer cells	8
Role of P450 enzymes of the Cyp2abfgs gene subfamilies in tobacco smoke-induced lung tumorigenesis in mice	8
Triple-negative breast cancer molecular subtypes and potential detection targets for biological therapy indications	8
Integrative analysis of enrichment and prognostic value of ferroptosis-related genes and pathways in multiple myeloma	8
TMEM16A inhibits autophagy and promotes the invasion of hypopharyngeal squamous cell carcinoma through mTOR pathway	8
LncRNA UCA1 promotes vasculogenic mimicry by targeting miR-1-3p in gastric cancer	7
The ubiquitin E3 ligase MDM2 induces chemoresistance in colorectal cancer by degradation of ING3	7
Retraction of: Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion	7
Identification and prioritization of tumour-associated antigens for immunotherapeutic and diagnostic capacity in epithelial ovarian cancer: a systematic literature review	7
Call for Applications	7
Dual activation of autophagy and mTOR by TFE3 fusions promotes tumorigenesis in rearranged renal cell carcinoma	7
CDK12 is a promising therapeutic target for the transcription cycle and DNA damage response in metastatic osteosarcoma	7
A watercress drink increases detoxification of common environmental carcinogens such as acrolein and benzene: results of a randomized clinical trial	7
Efficacy of depatuxizumab mafodotin (ABT-414) in preclinical models of head and neck cancer	7
miR-424-3p promotes metastasis of hepatocellular carcinoma via targeting the SRF-STAT1/2 axis	7
SNCA inhibits epithelial–mesenchymal transition and correlates to favorable prognosis of breast cancer	7
Mechanisms of tumor-associated macrophages promoting tumor immune escape	7
Construction and testing of a risk prediction classifier for cardia carcinoma	7
Smoking, alcohol, and colon cancer survival are modified by immune biomarkers: a population-representative study	7
Prognostic microRNA signature for estimating survival in patients with hepatocellular carcinoma	7
Morphology dynamics in intestinal crypt during postnatal development affect age-dependent susceptibility to radiation-induced intestinal tumorigenesis in Apc Min/+ mice	7
Genome-wide identification of aberrant alternative splicing and RNA-binding protein regulators in acute myeloid leukaemia which may contribute to immune microenvironment remodelling	6
Retraction: “The Bmi-1 polycomb protein antagonizes the (−)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival”	6
Inhibition of phospholipase D1 reduces pancreatic carcinogenesis in mice partly through a FAK-dependent mechanism	6
Retraction and replacement of: microRNA involvement in human cancer	6
The evolving role for surgery in pancreatic cancer	6
Aqueous extracts of Ocimum gratissimum mitigate colitis and protect against AOM/DSS-induced colorectal cancer in mice	6
Integrative functional screen of genomic loci uncovers CCND2 and its genetic regulatory mechanism in colorectal cancer development	6
Long non-coding RNA KB-1460A1.5 promotes ferroptosis by inhibiting mTOR/SREBP-1/SCD1-mediated polyunsaturated fatty acid desaturation in glioma	6
Utilizing the Life Span Study data in NASA astronaut cancer risk assessment	6
An update on the formation in tobacco, toxicity and carcinogenicity of Nʹ-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone	6
Dysregulation of HNF1B/Clusterin axis enhances disease progression in a highly aggressive subset of pancreatic cancer patients	6
CircCDK17 promotes the proliferation and metastasis of ovarian cancer cells by sponging miR-22-3p to regulate CD147 expression	6
Asbestos burden in lungs of mesothelioma patients with pleural plaques, lung fibrosis and/or ferruginous bodies at histology: a postmortem SEM-EDS study	6
Recent evolution of risk analyses in atomic bomb survivor studies: new methods and applications	6
Genomic and transcriptomic significance of multiple primary lung cancers detected by next-generation sequencing in clinical settings	6
Emerging evidence on the role of breast microbiota on the development of breast cancer in high-risk patients	6
Eight decades of research on the long-term health effects of radiation in atomic bomb survivors and their offspring	6
Cancer-associated fibroblasts-derived exosome-mediated transfer of miR-345-5p promotes the progression of colorectal cancer by targeting CDKN1A	6
GPS2 confers l-asparaginase resistance in acute lymphoblastic leukemia cells through ATF4/ASNS axis	6
Human papillomavirus (HPV) DNA methylation changes in HPV-associated head and neck cancer	5
Colorectal cancer cells with high metastatic potential drive metastasis by transmitting exosomal miR-20a-3p through modulating NF1/MAPK pathway	5
The effects of black raspberry lozenges on 4-hydroxy-1-(3-pyridyl)-1-butanone-releasing DNA adducts in buccal cells and urinary levels of N′-nitrosonornicotine and its glucuronide in active smokers	5
Transposable elements alter gene expression and may impact response to cisplatin therapy in ovarian cancer	5
The HPV16 E6, E7/miR-23b-3p/ICAT signaling axis promotes proliferation, migration, invasion and EMT of cervical cancer cells	5
Plasma proteomic profiling identified prognostic indicators with therapeutic potential for colorectal cancer	5
Transgelin: a tumor suppressor candidate in neuroblastoma	5
Reactions of [13C]-labelled tobacco smoke with DNA to generate selected adducts formed without metabolic activation	5
MIF/NR3C2 axis regulates glucose metabolism reprogramming in pancreatic cancer through MAPK–ERK and AP-1 pathways	5
miR-4461 inhibits liver cancer stem cells expansion and chemoresistance via regulating SIRT1	5
ETS1 deficiency in macrophages suppresses colorectal cancer progression by reducing the F4/80+TIM4+ macrophage population	5
Correction to: Arsenic disulfide synergizes with the phosphoinositide 3-kinase inhibitor PI-103 to eradicate acute myeloid leukemia stem cells by inducing differentiation	5
Mutational signatures and increased retrotransposon insertions in xeroderma pigmentosum variant skin tumors	5
ACSL4: a double-edged sword target in multiple myeloma, promotes cell proliferation and sensitizes cell to ferroptosis	4
Ginseng mediates its anticancer activity by inhibiting the expression of DNMTs and reactivating methylation-silenced genes in colorectal cancer	4
LncRNA CASC19 promotes gastric cancer progression through preventing CREB1 protein ubiquitin/proteasome-dependent degradation	4
Assessing the physiological relevance of the bioactivation of tobacco-specific carcinogen NNK and its metabolite NNAL: quantitative analyses of hydrolysis products from their protein adducts under dif	4
Pathological point of view on the atomic bomb-related solid cancers	4
Correction to: Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer	4
FZD6 promotes 5-fluorouracil resistance through inhibiting pyroptosis in colorectal cancer	4
CD133-containing microvesicles promote cancer progression by inducing M2-like tumor-associated macrophage polarization in the tumor microenvironment of colorectal cancer	4
The role of interleukin 17 in cancer: a systematic review	4
Editor-in-Chief’s Note—Thank you to Reviewers	4
TGF-β1 and TGF-β2 family members differentially modulate tumor initiation and invasiveness of primary liver cancer in a MMP14-dependent manner	4
Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression	4
Enhancing carboplatin sensitivity in ovarian cancer cells by blocking the mercapturic acid pathway transporter	4
Advanced glycation end products promote the progression of endometrial cancer via activating the RAGE/CHKA/PI3K/AKT signaling pathway	4
A dual approach to glioblastoma treatment with epigenetic reprogramming and neurogenetic modulation	4

Role of colorectal cancer-derived exosomes in modulating macrophage phenotype during tumor development	4
Retraction of: Genetic and clinical characteristics of BRCA-associated hereditary breast cancer in the West region of Kazakhstan	4
Retraction of: Pro-angiogenesis action of arsenic and its reversal by selenium-derived compounds	4
Correction to: Epigenetic silencing of O6 -methylguanine DNA methyltransferase gene in NiS-transformed cells	4
Editor-in-Chief’s Note—Thank you to Reviewers	4
Smoking and risk of colorectal cancer according to KRAS and BRAF mutation status in a Japanese prospective Study	3
ARID1Amutations in cancer development: mechanism and therapy	3
LncRNA CARD8-AS1 suppresses lung adenocarcinoma progression by enhancing TRIM25-mediated ubiquitination of TXNRD1	3
Polo-like kinase 4 (PLK4) as a therapeutic target in breast cancer	3
Age-related macrophage alterations are associated with carcinogenesis of colorectal cancer	3
Sitravatinib combined with PD-1 blockade enhances cytotoxic T-cell infiltration by M2 to M1 tumor macrophage repolarization in esophageal adenocarcinoma	3
tRF-29-79 regulates lung adenocarcinoma progression through mediating glutamine transporter SLC1A5	3
Dehydroabietylamine exerts antitumor effects by affecting nucleotide metabolism in gastric cancer	3
Triterpenoid ursolic acid regulates the environmental carcinogen benzo[a]pyrene-driven epigenetic and metabolic alterations in SKH-1 hairless mice for skin cancer interception	3
Effect of vitamin E δ-tocotrienol and aspirin on Wnt signaling in human colon cancer stem cells and in adenoma development in APCmin/+ mice	3
Andrew Zloza, MD, PhD (1978–2024)	3
Eighty years of cancer research after the atomic bombings of Hiroshima and Nagasaki	3
Co-targeting KRASG12D and the HER family is efficacious in colorectal cancer	3
The ubiquitin ligase STUB1 suppresses tumorigenesis of renal cell carcinomas through regulating YTHDF1 stability	3
TRIM14 suppressed the progression of NSCLC via hexosamine biosynthesis pathway	3
The BET inhibitor GNE-987 effectively induces anti-cancer effects in T-cell acute lymphoblastic leukemia by targeting enhancer regulated genes	3
The presence of intratumoral Porphyromonas gingivalis correlates with a previously defined pancreatic adenocarcinoma, immune cell expression phenotype and with tumor resident, adaptive immune r	3
Constitutive epidermal expression of osteopontin in osteopontin-null mice restores ultraviolet B-induced cutaneous squamous cell carcinomas to wild-type levels	3
Wnt/β-catenin Signaling in Hepatocellular Carcinoma: A Major Context-Dependent Contributor to Resistance to Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors	3
Asbestos exposure induces malignant-like phenotypes via minority MOMP and displays characteristics of drug-tolerant persister cells	3
Splicing transcriptome-wide association study to identify splicing events for pancreatic cancer risk	3
LncRNA MEG3 suppresses prostate cancer progression by mediating macrophage polarization via the miR-148a-3p/ARRDC3 signaling axis	3
Risk of clonal hematopoiesis in families exposed to radiation following the Chornobyl accident	3
Amlodipine, an L-type Ca2+ channel inhibitor, regulates release of extracellular vesicles from tumor cells	3
Retraction of: selective killing of human breast cancer cells by the styryl lactone (R)-goniothalamin is mediated by glutathione conjugation, induction of oxidative stress and marked reactivation of t	3
TERT and BRAF V600E mutations in thyroid cancer of World Trade Center Responders	3