Carcinogenesis

Article	Citations
Identification of biomarkers for the diagnosis and targets for therapy in patients with clear cell ovarian cancer: a systematic literature review	61
Genomic profile of radiation-induced early-onset mouse B-cell lymphoma recapitulates features of Philadelphia chromosome-like acute lymphoblastic leukemia in humans	55
miR-1304 targets KLK11 to regulate gastric cancer cell proliferation through the mTOR signaling pathway	35
Intermittent administration of tacrolimus enhances 
anti-tumor immunity in melanoma-bearing mice	30
LINC02418 upregulates EPHA2 by competitively sponging miR-372-3p to promote 5-Fu/DDP chemoresistance in colorectal cancer	29
Editor-In-Chief’s Editorial 2023	29
The putative oncogenic role of WDTC1 in colorectal cancer	27
Unravelling the distinct biological functions and potential therapeutic applications of TIMP2 in cancer	26
Regulatory mechanisms of PFKFB2 in glycolysis and tumor metabolism: implications for cancer therapy	25
Cancer-testis non-coding RNA LEF1-AS1 regulates the nuclear translocation of PDCD5 and suppresses its interaction with p53 signaling: a novel target for immunotherapy in esophageal squamous cell carci	23
Hepatocellular carcinoma risk variant modulates lncRNA HLA-DQB1-AS1 expression via a long-range enhancer–promoter interaction	23
LncRNA LINC02253 activates KRT18/MAPK/ERK pathway by mediating N6-methyladenosine modification of KRT18 mRNA in gastric cancer	22
The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes	22
Prognostic value of circulating tumor DNA in different cancer types detected by ultra-low-pass whole-genome sequencing: a systematic review and patient-level survival data meta-analysis	21
The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model	21
miR-22 promotes immunosuppression via activating JAK/STAT3 signaling in cutaneous squamous cell carcinoma	21
Redefining pancreatic cancer management with tumor-agnostic precision medicine	21
O-GlcNAcylation of RAB10 promotes hepatocellular carcinoma progression	21
Identification of HCAR1 as a ferroptosis-related biomarker of gastric cancer based on a novel ferroptosis-related prognostic model and in vitro experiments	20
MiR-145 modulates the radiosensitivity of non-small cell lung cancer cells by suppression of TMOD3	19
Intratumoral vitamin D signaling and lethal prostate cancer	19
SIAH1/CTR9 axis promotes the epithelial–mesenchymal transition of hepatocellular carcinoma	19
Longitudinal single-cell RNA model aids prediction of EGFR-TKI resistance	19
Ehm2 transcript variant 1 inhibits breast cancer progression and increases E-cadherin stability	19
Editor-in-Chief’s Note—Thank you to Reviewers	19

Night shift work and breast cancer risk: a meta-analysis of observational epidemiological studies	18
miR-3154 promotes hepatocellular carcinoma progression via suppressing HNF4α	17
Characterization of adductomic totality of NNK, (R)-NNAL and (S)-NNAL in A/J mice, and their correlations with distinct lung carcinogenicity	16
Long non-coding RNA NRAV in the 12q24.31 risk locus drives gastric cancer development through glucose metabolism reprogramming	16
Machine learning based on biological context facilitates the identification of microvascular invasion in intrahepatic cholangiocarcinoma	16
Epidemiological evidence for associations between variants in microRNA and cancer risk	16
Long noncoding RNA XIST: a novel independent prognostic biomarker for patients with ABC-DLBCL receiving R-CHOP treatment	16
LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism	16
Association between new plasma inflammatory markers and risk of colorectal neoplasms in individuals over 50 years old	15
Human cytomegalovirus alters immune cell profile with potential implications for patient survival in head and neck cancer	15
Urinary glyphosate levels and association with mortality in the 2013–16 National Health and Nutrition Examination Survey	14
DUT enhances drug resistance to proteasome inhibitors via promoting mitochondrial function in multiple myeloma	14
SLC38A6, regulated by EP300-mediated modifications of H3K27ac, promotes cell proliferation, glutamine metabolism and mitochondrial respiration in hepatocellular carcinoma	14
Solamargine enhanced gefitinib antitumor effect via regulating MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway in non-small cell lung cancer	14
ITGA2 as a prognostic factor of glioma promotes GSCs invasion and EMT by activating STAT3 phosphorylation	14
α5-nAChR/STAT3/CD47 axis contributed to nicotine-related lung adenocarcinoma progression and immune escape	14
MPZL1 upregulation promotes tumor metastasis and correlates with unfavorable prognosis in non-small cell lung cancer	13
PPM1G promotes the progression of lung adenocarcinoma by inhibiting p38 activation via dephosphorylation of MEK6	13
Establishing a new-onset diabetes-related metabolism signature for predicting the prognosis and immune landscape in pancreatic cancer	13
MUC1-C dictates neuroendocrine lineage specification in pancreatic ductal adenocarcinomas	13
Prognostic value of exosomal noncoding RNA in hepatocellular carcinoma: a meta-analysis	13
Outcome of clinical experience of introducing a patient with secondary systemic AL-amyloidosis associated with multiple myeloma	13
A pleiotropic ATM variant (rs1800057 C>G) is associated with risk of multiple cancers	13
Antibody–drug conjugates in breast cancer	13
Copine 1 predicts poor clinical outcomes by promoting M2 macrophage activation in ovarian cancer	13
MALAT1 regulates network of microRNA-15a/16–VEGFA to promote tumorigenesis and angiogenesis in multiple myeloma	12
Genetic variants in glycosylation pathways are associated with colorectal cancer risk	12
SSH1 promotes progression of intrahepatic cholangiocarcinoma via p38 MAPK-CXCL8 axis	12
Actinomycin D synergizes with Doxorubicin in triple-negative breast cancer by inducing P53-dependent cell apoptosis	12
Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells	12
The impact of reproductive factors on breast tumor and normal-adjacent tissue immune profile from menarche to menopause	12
CYR61 confers chemoresistance by upregulating survivin expression in triple-negative breast cancer	12
Germline alteration analysis reveals EPHB4R91H mutation as a key player in multiple primary lung tumors	12
BRAF V600E-induced distinct DNA damage response defines the therapeutic potential of p53 activation for TP53 wild-type colorectal cancer	12
Immune-related genes for the prediction of response to imatinib therapy in chronic myeloid leukemia	12
Elevated expression of the membrane-anchored serine protease TMPRSS11E in NSCLC progression	11
CDKN2B antisense RNA 1 suppresses tumor growth in human colorectal cancer by targeting MAPK inactivator dual-specificity phosphatase 1	11
LncRNA CCAT1 participates in pancreatic ductal adenocarcinoma progression by forming a positive feedback loop with c-Myc	11
Sevoflurane inhibits lung cancer development by promoting FUS1 transcription via downregulating IRF6	11
AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer	11
From precursor to cancer: decoding the intrinsic and extrinsic pathways of pancreatic intraepithelial neoplasia progression	11
CacyBP promotes the development of lung adenocarcinoma by regulating OTUD5	11
SMARCA4/BRG1 deficiency induces a targetable dependence on oxidative phosphorylation in clear cell renal cell carcinoma	11
Suppressing the activation of protein kinase A as a DNA damage-independent mechanistic lead for dihydromethysticin prophylaxis of NNK-induced lung carcinogenesis	10
The miR-345-3p/PPP2CA signaling axis promotes proliferation and invasion of breast cancer cells	10
ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment	10
NamiRNA-enhancer network of miR-492 activates the NR2C1-TGF-β/Smad3 pathway to promote epithelial-mesenchymal transition of pancreatic cancer	10
E3 ubiquitin ligase RNF148 functions as an oncogene in colorectal cancer by ubiquitination-mediated degradation of CHAC2	10
Cancer-associated fibroblasts promote cancer stemness by inducing expression of the chromatin-modifying protein CBX4 in squamous cell carcinoma	10
Role of caveolin-1 in human organ function and disease: friend or foe?	10

m6A-modified circASXL1 promotes proliferation and migration of ovarian cancer through the miR-320d/RACGAP1 axis	10
LncRNAs act as modulators of macrophages within the tumor microenvironment	10
Stem cells, Notch-1 signaling, and oxidative stress: a hellish trio in cancer development and progression within the airways. Is there a role for natural compounds?	10
A polymorphic variant in telomere maintenance is associated with worrisome features and high-risk stigmata development in IPMNs	10
Bipolar high-frequency electric welding in radical resection of frontal sinus tumors	9
Pan-cancer analysis of G6PD carcinogenesis in human tumors	9
Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers	9
Somatic p53 mutations that are markedly overrepresented in lung cancer confer resistance to ROS-induced cell death	9
Corrigendum to: A functional CNVR_3425.1 damping lincRNA FENDRR increases lifetime risk of lung cancer and COPD in Chinese	9
Modulation of the oral glucocorticoid system during black raspberry mediated oral cancer chemoprevention	9
Dietary phytoestrogen intake and ovarian cancer risk: a prospective study in the prostate, lung, colorectal and ovarian (PLCO) cohort	9
Targeted sequencing and functional interrogation identified novel variant at 12q14.2 associated with risk of ovarian cancer in Han Chinese women	9
Chemopreventive efficacy of silibinin against basal cell carcinoma growth and progression in UVB-irradiated Ptch+/– mice	9
MIF as a prognostic biomarker in multiple myeloma: clinical significance and in vitro effects	9
Hepatitis B virus X protein promotes hepatocarcinogenesis via the activation of HMGA2/STC2 signaling to counteract oxidative stress-induced cell death	9
Copper in colorectal cancer patients: a systematic review and meta-analysis	9
Triple-negative breast cancer molecular subtypes and potential detection targets for biological therapy indications	9
Editor-In-Chief’s Editorial 2022 January Issue 43:1	9
Maternal soybean genistein on prevention of later-life breast cancer through inherited epigenetic regulations	8
CRL4DCAF4 E3 ligase-mediated degradation of MEN1 transcriptionally reactivates hTERT to sustain immortalization in colorectal cancer cells	8
Olfactomedin 4 promotes gastric cancer cell G2/M progression and serves as a therapeutic target in gastric adenocarcinoma	8
Thymoquinone inhibits lung cancer stem cell properties via triggering YAP degradation	8
The influence of homologous recombination repair on temozolomide chemosensitivity in gliomas	8
Erratum to: Butyrate-containing structured lipids act on HDAC4, HDAC6, DNA damage and telomerase activity during promotion of experimental hepatocarcinogenesis	8
CCL18 promotes migration and invasion of multiple myeloma cells and is associated with poor prognosis	8
Plasma thioredoxin reductase: a potential diagnostic biomarker for gastric cancer	8
What causes prostate cancer-learning from a tragedy	8
Integrative analysis of enrichment and prognostic value of ferroptosis-related genes and pathways in multiple myeloma	8
CDK12 is a promising therapeutic target for the transcription cycle and DNA damage response in metastatic osteosarcoma	7
Mechanisms of tumor-associated macrophages promoting tumor immune escape	7
HOXA10 promote pancreatic cancer progression via directly activating canonical NF-κB signaling pathway	7
Construction and testing of a risk prediction classifier for cardia carcinoma	7
Asbestos burden in lungs of mesothelioma patients with pleural plaques, lung fibrosis and/or ferruginous bodies at histology: a postmortem SEM-EDS study	7
Acetaldehyde induces NER repairable mutagenic DNA lesions	7
TMEM16A inhibits autophagy and promotes the invasion of hypopharyngeal squamous cell carcinoma through mTOR pathway	7
Morphology dynamics in intestinal crypt during postnatal development affect age-dependent susceptibility to radiation-induced intestinal tumorigenesis in Apc Min/+ mice	7
GNA14’s interaction with RACK1 inhibits hepatocellular carcinoma progression through reducing MAPK/JNK and PI3K/AKT signaling pathway	7
Urinary biomarkers for the detection of ovarian cancer: a systematic review	7
Retraction of: DNA methylation-mediated downregulation of PTPN3 attenuates to boost TGF-β signaling in osteosarcoma cells	7
miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization	7
Early dynamics of circulating tumor DNA predict chemotherapy responses for patients with esophageal cancer	7
LncRNA UCA1 promotes vasculogenic mimicry by targeting miR-1-3p in gastric cancer	7
Identification and prioritization of tumour-associated antigens for immunotherapeutic and diagnostic capacity in epithelial ovarian cancer: a systematic literature review	7
Call for Applications	7
SNCA inhibits epithelial–mesenchymal transition and correlates to favorable prognosis of breast cancer	7
Long non-coding RNA KB-1460A1.5 promotes ferroptosis by inhibiting mTOR/SREBP-1/SCD1-mediated polyunsaturated fatty acid desaturation in glioma	6
Integrative functional screen of genomic loci uncovers CCND2 and its genetic regulatory mechanism in colorectal cancer development	6
CHRAC1 promotes human lung cancer growth through regulating YAP transcriptional activity	6
Genome-wide identification of aberrant alternative splicing and RNA-binding protein regulators in acute myeloid leukaemia which may contribute to immune microenvironment remodelling	6
Efficacy of depatuxizumab mafodotin (ABT-414) in preclinical models of head and neck cancer	6
The anaphase-promoting complex/cyclosome co-activator, Cdh1, is a novel target of human papillomavirus 16 E7 oncoprotein in cervical oncogenesis	6
Genomic and transcriptomic significance of multiple primary lung cancers detected by next-generation sequencing in clinical settings	6
DNMT3A epigenetically regulates key microRNAs involved in epithelial-to-mesenchymal transition in prostate cancer	6
Inhibition of phospholipase D1 reduces pancreatic carcinogenesis in mice partly through a FAK-dependent mechanism	6
Emerging evidence on the role of breast microbiota on the development of breast cancer in high-risk patients	6
The ubiquitin E3 ligase MDM2 induces chemoresistance in colorectal cancer by degradation of ING3	6
An update on the formation in tobacco, toxicity and carcinogenicity of Nʹ-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone	6
Gastric tumorigenesis induced by combining Helicobacter pylori infection and chronic alcohol through IL-10 inhibition	6
Combinatory lung tumor inhibition by myo-inositol and iloprost/rapamycin: association with immunomodulation	6
GPS2 confers L-asparaginase resistance in acute lymphoblastic leukemia cells through ATF4/ASNS axis	6
Prognostic microRNA signature for estimating survival in patients with hepatocellular carcinoma	6
Targeting cyclin-dependent kinase 7—association between CDK7 and pMED1 expression in prostate cancer tissue	6
MCT1 expression is independently related to shorter cancer-specific survival in clear cell renal cell carcinoma	6
miR-424-3p promotes metastasis of hepatocellular carcinoma via targeting the SRF-STAT1/2 axis	6
Aspirin suppresses breast cancer metastasis to lung by targeting anoikis resistance	5
miR-4461 inhibits liver cancer stem cells expansion and chemoresistance via regulating SIRT1	5
The evolving role for surgery in pancreatic cancer	5
Mutational signatures and increased retrotransposon insertions in xeroderma pigmentosum variant skin tumors	5
Human papillomavirus (HPV) DNA methylation changes in HPV-associated head and neck cancer	5
Colorectal cancer cells with high metastatic potential drive metastasis by transmitting exosomal miR-20a-3p through modulating NF1/MAPK pathway	5
Transposable elements alter gene expression and may impact response to cisplatin therapy in ovarian cancer	5
Exosomal microRNA-23b-3p promotes tumor angiogenesis and metastasis by targeting PTEN in salivary adenoid cystic carcinoma	5
Aqueous extracts of Ocimum gratissimum mitigate colitis and protect against AOM/DSS-induced colorectal cancer in mice	5
The HPV16 E6, E7/miR-23b-3p/ICAT signaling axis promotes proliferation, migration, invasion and EMT of cervical cancer cells	5
Dysregulation of HNF1B/Clusterin axis enhances disease progression in a highly aggressive subset of pancreatic cancer patients	5
Understanding the role of dopamine in cancer: past, present and future	5
CD133-containing microvesicles promote cancer progression by inducing M2-like tumor-associated macrophage polarization in the tumor microenvironment of colorectal cancer	5
Ginseng mediates its anticancer activity by inhibiting the expression of DNMTs and reactivating methylation-silenced genes in colorectal cancer	5
MIF/NR3C2 axis regulates glucose metabolism reprogramming in pancreatic cancer through MAPK–ERK and AP-1 pathways	5
Intratumoral microbiota: new frontiers in tumor immunity	5

CircCDK17 promotes the proliferation and metastasis of ovarian cancer cells by sponging miR-22-3p to regulate CD147 expression	5
Cancer-associated fibroblasts-derived exosome-mediated transfer of miR-345-5p promotes the progression of colorectal cancer by targeting CDKN1A	5
LncRNA CASC19 promotes gastric cancer progression through preventing CREB1 protein ubiquitin/proteasome-dependent degradation	5
Wild-type p53 suppresses formin-binding protein-17 (FBP17) to reduce invasion	5
Reactions of [13C]-labelled tobacco smoke with DNA to generate selected adducts formed without metabolic activation	4
Advanced glycation end products promote the progression of endometrial cancer via activating the RAGE/CHKA/PI3K/AKT signaling pathway	4
Editor-in-Chief’s Note—Thank you to Reviewers	4
Inhibition of lysosomal acid β-glucosidase induces cell apoptosis via impairing mitochondrial clearance in pancreatic cancer	4
Correction to: Epigenetic silencing of O6 -methylguanine DNA methyltransferase gene in NiS-transformed cells	4
Correction to: Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer	4
Age-related macrophage alterations are associated with carcinogenesis of colorectal cancer	4
Retraction of: Pro-angiogenesis action of arsenic and its reversal by selenium-derived compounds	4
The role of interleukin 17 in cancer: a systematic review	4
Editor-in-Chief’s Note—Thank you to Reviewers	4
Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression	4
Sitravatinib combined with PD-1 blockade enhances cytotoxic T-cell infiltration by M2 to M1 tumor macrophage repolarization in esophageal adenocarcinoma	4
tRF-29-79 regulates lung adenocarcinoma progression through mediating glutamine transporter SLC1A5	4
Genomic landscape of chemical-induced lung tumors under Nrf2 different expression levels	4
ACSL4: a double-edged sword target in multiple myeloma, promotes cell proliferation and sensitizes cell to ferroptosis	4
ETS1 deficiency in macrophages suppresses colorectal cancer progression by reducing the F4/80+TIM4+ macrophage population	4
Retraction of: Genetic and clinical characteristics of BRCA-associated hereditary breast cancer in the West region of Kazakhstan	4
Trefoil factor family 2 inhibits cholangiocarcinogenesis by regulating the PTEN pathway in mice	4
TRIM14 suppressed the progression of NSCLC via hexosamine biosynthesis pathway	4
Detection of DNA adducts derived from the tobacco carcinogens, benzo[a]pyrene and dibenzo[def,p]chrysene in human oral buccal cells	4
PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis	3
Inhibition of lung adenocarcinoma by combinations of sulfasalazine (SAS) and disulfiram-copper (DSF-Cu) in cell line models and mice	3
The presence of intratumoral Porphyromonas gingivalis correlates with a previously defined pancreatic adenocarcinoma, immune cell expression phenotype and with tumor resident, adaptive immune r	3
Correction to: Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation	3
Dehydroabietylamine exerts antitumor effects by affecting nucleotide metabolism in gastric cancer	3
Andrew Zloza, MD, PhD (1978–2024)	3
NFE2L3 promotes tumor progression and predicts a poor prognosis of bladder cancer	3
The BET inhibitor GNE-987 effectively induces anti-cancer effects in T-cell acute lymphoblastic leukemia by targeting enhancer regulated genes	3
LncRNA MEG3 suppresses prostate cancer progression by mediating macrophage polarization via the miR-148a-3p/ARRDC3 signaling axis	3
Retracted: Genetic and clinical characteristics of BRCA-associated hereditary breast cancer in the West region of Kazakhstan	3
Gasdermin D represses inflammation-induced colon cancer development by regulating apoptosis	3
Increased acrolein–DNA adducts in buccal brushings of e-cigarette users	3
Smoking and risk of colorectal cancer according to KRAS and BRAF mutation status in a Japanese prospective Study	3
ARID1Amutations in cancer development: mechanism and therapy	3
Transcription phenotype of circulating tumor cells in non-metastatic breast cancer	3
Type-2 cGMP-dependent protein kinase suppresses proliferation and carcinogenesis in the colon epithelium	3
The ubiquitin ligase STUB1 suppresses tumorigenesis of renal cell carcinomas through regulating YTHDF1 stability	3
LncRNA CARD8-AS1 suppresses lung adenocarcinoma progression by enhancing TRIM25-mediated ubiquitination of TXNRD1	3
TERT and BRAF V600E mutations in thyroid cancer of World Trade Center Responders	3
Prognostic impact of tumor-specific insulin-like growth factor binding protein 7 (IGFBP7) levels in breast cancer: a prospective cohort study	3
Amlodipine, an L-type Ca2+ channel inhibitor, regulates release of extracellular vesicles from tumor cells	3
Triterpenoid ursolic acid regulates the environmental carcinogen benzo[a]pyrene-driven epigenetic and metabolic alterations in SKH-1 hairless mice for skin cancer interception	3
Effect of vitamin E δ-tocotrienol and aspirin on Wnt signaling in human colon cancer stem cells and in adenoma development in APCmin/+ mice	3
Splicing transcriptome-wide association study to identify splicing events for pancreatic cancer risk	3
Commentary: Role and communications of cancer hazard determinations	3
Increased H2O2 levels and p53 stabilization lead to mitochondrial dysfunction in XPC-deficient cells	3
Enhancing carboplatin sensitivity in ovarian cancer cells by blocking the mercapturic acid pathway transporter	3
USP53 activated by H3K27 acetylation regulates cell viability, apoptosis and metabolism in esophageal carcinoma via the AMPK signaling pathway	3
On the road to colorectal cancer development: crosstalk between the gut microbiota, metabolic reprogramming, and epigenetic modifications	3