Carcinogenesis

Article	Citations
Identification of biomarkers for the diagnosis and targets for therapy in patients with clear cell ovarian cancer: a systematic literature review	55
Genomic profile of radiation-induced early-onset mouse B-cell lymphoma recapitulates features of Philadelphia chromosome-like acute lymphoblastic leukemia in humans	52
miR-1304 targets KLK11 to regulate gastric cancer cell proliferation through the mTOR signaling pathway	35
Editor-In-Chief’s Editorial 2023	29
Intermittent administration of tacrolimus enhances 
anti-tumor immunity in melanoma-bearing mice	29
The putative oncogenic role of WDTC1 in colorectal cancer	28
Unravelling the distinct biological functions and potential therapeutic applications of TIMP2 in cancer	28
Cancer-testis non-coding RNA LEF1-AS1 regulates the nuclear translocation of PDCD5 and suppresses its interaction with p53 signaling: a novel target for immunotherapy in esophageal squamous cell carci	26
LINC02418 upregulates EPHA2 by competitively sponging miR-372-3p to promote 5-Fu/DDP chemoresistance in colorectal cancer	26
O-GlcNAcylation of RAB10 promotes hepatocellular carcinoma progression	25
The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model	24
Hepatocellular carcinoma risk variant modulates lncRNA HLA-DQB1-AS1 expression via a long-range enhancer–promoter interaction	24
Prognostic value of circulating tumor DNA in different cancer types detected by ultra-low-pass whole-genome sequencing: a systematic review and patient-level survival data meta-analysis	22
The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes	22
LncRNA LINC02253 activates KRT18/MAPK/ERK pathway by mediating N6-methyladenosine modification of KRT18 mRNA in gastric cancer	21
miR-22 promotes immunosuppression via activating JAK/STAT3 signaling in cutaneous squamous cell carcinoma	21
Redefining pancreatic cancer management with tumor-agnostic precision medicine	21
Use of hair products in relation to ovarian cancer risk	21
Ehm2 transcript variant 1 inhibits breast cancer progression and increases E-cadherin stability	20
Intratumoral vitamin D signaling and lethal prostate cancer	20
Editor-in-Chief’s Note—Thank you to Reviewers	20
CDC42EP3 is a key promoter involved in the development and progression of gastric cancer	19
Night shift work and breast cancer risk: a meta-analysis of observational epidemiological studies	19
Machine learning based on biological context facilitates the identification of microvascular invasion in intrahepatic cholangiocarcinoma	18
LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism	18

Long non-coding RNA NRAV in the 12q24.31 risk locus drives gastric cancer development through glucose metabolism reprogramming	18
Long noncoding RNA XIST: a novel independent prognostic biomarker for patients with ABC-DLBCL receiving R-CHOP treatment	17
Characterization of adductomic totality of NNK, (R)-NNAL and (S)-NNAL in A/J mice, and their correlations with distinct lung carcinogenicity	17
Epidemiological evidence for associations between variants in microRNA and cancer risk	17
Association between new plasma inflammatory markers and risk of colorectal neoplasms in individuals over 50 years old	17
SIAH1/CTR9 axis promotes the epithelial–mesenchymal transition of hepatocellular carcinoma	17
miR-3154 promotes hepatocellular carcinoma progression via suppressing HNF4α	17
Human cytomegalovirus alters immune cell profile with potential implications for patient survival in head and neck cancer	16
α5-nAChR/STAT3/CD47 axis contributed to nicotine-related lung adenocarcinoma progression and immune escape	16
MiR-145 modulates the radiosensitivity of non-small cell lung cancer cells by suppression of TMOD3	16
Solamargine enhanced gefitinib antitumor effect via regulating MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway in non-small cell lung cancer	16
Cytoplasmic EBP50 and elevated PARP1 are unfavorable prognostic factors in ovarian clear cell carcinoma	15
Antibody–drug conjugates in breast cancer	15
A pleiotropic ATM variant (rs1800057 C>G) is associated with risk of multiple cancers	15
MUC1-C dictates neuroendocrine lineage specification in pancreatic ductal adenocarcinomas	15
DUT enhances drug resistance to proteasome inhibitors via promoting mitochondrial function in multiple myeloma	15
Urinary glyphosate levels and association with mortality in the 2013–16 National Health and Nutrition Examination Survey	14
MPZL1 upregulation promotes tumor metastasis and correlates with unfavorable prognosis in non-small cell lung cancer	14
Establishing a new-onset diabetes-related metabolism signature for predicting the prognosis and immune landscape in pancreatic cancer	14
Genome-wide gene–smoking interaction study identified novel susceptibility loci for non-small cell lung cancer in Chinese populations	14
ITGA2 as a prognostic factor of glioma promotes GSCs invasion and EMT by activating STAT3 phosphorylation	14
Prognostic value of exosomal noncoding RNA in hepatocellular carcinoma: a meta-analysis	14
PPM1G promotes the progression of lung adenocarcinoma by inhibiting p38 activation via dephosphorylation of MEK6	14
Copine 1 predicts poor clinical outcomes by promoting M2 macrophage activation in ovarian cancer	14
LncRNA PCBP1-AS1 correlated with the functional states of cancer cells and inhibited lung adenocarcinoma metastasis by suppressing the EMT progression	14
Germline alteration analysis reveals EPHB4R91H mutation as a key player in multiple primary lung tumors	13
BRAF V600E-induced distinct DNA damage response defines the therapeutic potential of p53 activation for TP53 wild-type colorectal cancer	13
Constitutive Hedgehog/GLI2 signaling drives extracutaneous basaloid squamous cell carcinoma development and bone remodeling	13
Genetic variants in glycosylation pathways are associated with colorectal cancer risk	13
SLC38A6, regulated by EP300-mediated modifications of H3K27ac, promotes cell proliferation, glutamine metabolism and mitochondrial respiration in hepatocellular carcinoma	13
Outcome of clinical experience of introducing a patient with secondary systemic AL-amyloidosis associated with multiple myeloma	13
Immune-related genes for the prediction of response to imatinib therapy in chronic myeloid leukemia	13
Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells	13
SSH1 promotes progression of intrahepatic cholangiocarcinoma via p38 MAPK-CXCL8 axis	12
SMARCA4/BRG1 deficiency induces a targetable dependence on oxidative phosphorylation in clear cell renal cell carcinoma	12
MALAT1 regulates network of microRNA-15a/16–VEGFA to promote tumorigenesis and angiogenesis in multiple myeloma	12
CYR61 confers chemoresistance by upregulating survivin expression in triple-negative breast cancer	12
Elevated expression of the membrane-anchored serine protease TMPRSS11E in NSCLC progression	12
Actinomycin D synergizes with Doxorubicin in triple-negative breast cancer by inducing P53-dependent cell apoptosis	12
The impact of reproductive factors on breast tumor and normal-adjacent tissue immune profile from menarche to menopause	12
From precursor to cancer: decoding the intrinsic and extrinsic pathways of pancreatic intraepithelial neoplasia progression	12
CacyBP promotes the development of lung adenocarcinoma by regulating OTUD5	11
Cancer-associated fibroblasts promote cancer stemness by inducing expression of the chromatin-modifying protein CBX4 in squamous cell carcinoma	11
Contribution of the microbiota and their secretory products to inflammation and colorectal cancer pathogenesis: the role of toll-like receptors	11
Stem cells, Notch-1 signaling, and oxidative stress: a hellish trio in cancer development and progression within the airways. Is there a role for natural compounds?	11
CDKN2B antisense RNA 1 suppresses tumor growth in human colorectal cancer by targeting MAPK inactivator dual-specificity phosphatase 1	11
Dual inhibition of cMET and EGFR by microRNA-338-5p suppresses metastasis of esophageal squamous cell carcinoma	11
LncRNA CCAT1 participates in pancreatic ductal adenocarcinoma progression by forming a positive feedback loop with c-Myc	11
Sevoflurane inhibits lung cancer development by promoting FUS1 transcription via downregulating IRF6	11
AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer	11

ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment	11
Copper in colorectal cancer patients: a systematic review and meta-analysis	11
m6A-modified circASXL1 promotes proliferation and migration of ovarian cancer through the miR-320d/RACGAP1 axis	10
E3 ubiquitin ligase RNF148 functions as an oncogene in colorectal cancer by ubiquitination-mediated degradation of CHAC2	10
Editor-In-Chief’s Editorial 2022 January Issue 43:1	10
Suppressing the activation of protein kinase A as a DNA damage-independent mechanistic lead for dihydromethysticin prophylaxis of NNK-induced lung carcinogenesis	10
Dietary phytoestrogen intake and ovarian cancer risk: a prospective study in the prostate, lung, colorectal and ovarian (PLCO) cohort	10
Pan-cancer analysis of G6PD carcinogenesis in human tumors	10
NamiRNA-enhancer network of miR-492 activates the NR2C1-TGF-β/Smad3 pathway to promote epithelial-mesenchymal transition of pancreatic cancer	10
The miR-345-3p/PPP2CA signaling axis promotes proliferation and invasion of breast cancer cells	10
Role of caveolin-1 in human organ function and disease: friend or foe?	10
LncRNAs act as modulators of macrophages within the tumor microenvironment	10
A polymorphic variant in telomere maintenance is associated with worrisome features and high-risk stigmata development in IPMNs	10
Bipolar high-frequency electric welding in radical resection of frontal sinus tumors	9
Triple-negative breast cancer molecular subtypes and potential detection targets for biological therapy indications	9
Chemopreventive efficacy of silibinin against basal cell carcinoma growth and progression in UVB-irradiated Ptch+/– mice	9
The power and the promise of circRNAs for cancer precision medicine with functional diagnostics and prognostic prediction	9
Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers	9
Corrigendum to: A functional CNVR_3425.1 damping lincRNA FENDRR increases lifetime risk of lung cancer and COPD in Chinese	9
Olfactomedin 4 promotes gastric cancer cell G2/M progression and serves as a therapeutic target in gastric adenocarcinoma	9
Hepatitis B virus X protein promotes hepatocarcinogenesis via the activation of HMGA2/STC2 signaling to counteract oxidative stress-induced cell death	9
What causes prostate cancer-learning from a tragedy	8
Modulation of the oral glucocorticoid system during black raspberry mediated oral cancer chemoprevention	8
TMEM16A inhibits autophagy and promotes the invasion of hypopharyngeal squamous cell carcinoma through mTOR pathway	8
Mechanisms of tumor-associated macrophages promoting tumor immune escape	8
Plasma thioredoxin reductase: a potential diagnostic biomarker for gastric cancer	8
The influence of homologous recombination repair on temozolomide chemosensitivity in gliomas	8
CRL4DCAF4 E3 ligase-mediated degradation of MEN1 transcriptionally reactivates hTERT to sustain immortalization in colorectal cancer cells	8
CCL18 promotes migration and invasion of multiple myeloma cells and is associated with poor prognosis	8
LncRNA UCA1 promotes vasculogenic mimicry by targeting miR-1-3p in gastric cancer	8
Early dynamics of circulating tumor DNA predict chemotherapy responses for patients with esophageal cancer	8
Erratum to: Butyrate-containing structured lipids act on HDAC4, HDAC6, DNA damage and telomerase activity during promotion of experimental hepatocarcinogenesis	8
Integrative analysis of enrichment and prognostic value of ferroptosis-related genes and pathways in multiple myeloma	8
Thymoquinone inhibits lung cancer stem cell properties via triggering YAP degradation	8
Maternal soybean genistein on prevention of later-life breast cancer through inherited epigenetic regulations	8
CDK12 is a promising therapeutic target for the transcription cycle and DNA damage response in metastatic osteosarcoma	8
The ubiquitin E3 ligase MDM2 induces chemoresistance in colorectal cancer by degradation of ING3	7
miR-424-3p promotes metastasis of hepatocellular carcinoma via targeting the SRF-STAT1/2 axis	7
Morphology dynamics in intestinal crypt during postnatal development affect age-dependent susceptibility to radiation-induced intestinal tumorigenesis in Apc Min/+ mice	7
HOXA10 promote pancreatic cancer progression via directly activating canonical NF-κB signaling pathway	7
MCT1 expression is independently related to shorter cancer-specific survival in clear cell renal cell carcinoma	7
Identification and prioritization of tumour-associated antigens for immunotherapeutic and diagnostic capacity in epithelial ovarian cancer: a systematic literature review	7
Urinary biomarkers for the detection of ovarian cancer: a systematic review	7
SNCA inhibits epithelial–mesenchymal transition and correlates to favorable prognosis of breast cancer	7
Acetaldehyde induces NER repairable mutagenic DNA lesions	7
GNA14’s interaction with RACK1 inhibits hepatocellular carcinoma progression through reducing MAPK/JNK and PI3K/AKT signaling pathway	7
Construction and testing of a risk prediction classifier for cardia carcinoma	7
Call for Applications	7
miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization	7
The case for a cancer paradox initiative	7
Emerging evidence on the role of breast microbiota on the development of breast cancer in high-risk patients	7
Genome-wide identification of aberrant alternative splicing and RNA-binding protein regulators in acute myeloid leukaemia which may contribute to immune microenvironment remodelling	6
Targeting cyclin-dependent kinase 7—association between CDK7 and pMED1 expression in prostate cancer tissue	6
Combinatory lung tumor inhibition by myo-inositol and iloprost/rapamycin: association with immunomodulation	6
Inhibition of phospholipase D1 reduces pancreatic carcinogenesis in mice partly through a FAK-dependent mechanism	6
DNMT3A epigenetically regulates key microRNAs involved in epithelial-to-mesenchymal transition in prostate cancer	6
Asbestos burden in lungs of mesothelioma patients with pleural plaques, lung fibrosis and/or ferruginous bodies at histology: a postmortem SEM-EDS study	6
Efficacy of depatuxizumab mafodotin (ABT-414) in preclinical models of head and neck cancer	6
Retraction of: DNA methylation-mediated downregulation of PTPN3 attenuates to boost TGF-β signaling in osteosarcoma cells	6
CHRAC1 promotes human lung cancer growth through regulating YAP transcriptional activity	6
Long non-coding RNA KB-1460A1.5 promotes ferroptosis by inhibiting mTOR/SREBP-1/SCD1-mediated polyunsaturated fatty acid desaturation in glioma	6
Prognostic microRNA signature for estimating survival in patients with hepatocellular carcinoma	6
The anaphase-promoting complex/cyclosome co-activator, Cdh1, is a novel target of human papillomavirus 16 E7 oncoprotein in cervical oncogenesis	6
Integrative functional screen of genomic loci uncovers CCND2 and its genetic regulatory mechanism in colorectal cancer development	6
Genomic and transcriptomic significance of multiple primary lung cancers detected by next-generation sequencing in clinical settings	6
An update on the formation in tobacco, toxicity and carcinogenicity of Nʹ-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone	6
CD133-containing microvesicles promote cancer progression by inducing M2-like tumor-associated macrophage polarization in the tumor microenvironment of colorectal cancer	5
Dysregulation of HNF1B/Clusterin axis enhances disease progression in a highly aggressive subset of pancreatic cancer patients	5
The HPV16 E6, E7/miR-23b-3p/ICAT signaling axis promotes proliferation, migration, invasion and EMT of cervical cancer cells	5
MIF/NR3C2 axis regulates glucose metabolism reprogramming in pancreatic cancer through MAPK–ERK and AP-1 pathways	5
Aqueous extracts of Ocimum gratissimum mitigate colitis and protect against AOM/DSS-induced colorectal cancer in mice	5
CircCDK17 promotes the proliferation and metastasis of ovarian cancer cells by sponging miR-22-3p to regulate CD147 expression	5
Reactions of [13C]-labelled tobacco smoke with DNA to generate selected adducts formed without metabolic activation	5
LncRNA CASC19 promotes gastric cancer progression through preventing CREB1 protein ubiquitin/proteasome-dependent degradation	5
Colorectal cancer cells with high metastatic potential drive metastasis by transmitting exosomal miR-20a-3p through modulating NF1/MAPK pathway	5
Aspirin suppresses breast cancer metastasis to lung by targeting anoikis resistance	5
Human papillomavirus (HPV) DNA methylation changes in HPV-associated head and neck cancer	5
Vascular endothelial cell-derived exosomal miR-30a-5p inhibits lung adenocarcinoma malignant progression by targeting CCNE2	5
Transposable elements alter gene expression and may impact response to cisplatin therapy in ovarian cancer	5
Gastric tumorigenesis induced by combining Helicobacter pylori infection and chronic alcohol through IL-10 inhibition	5

miR-4461 inhibits liver cancer stem cells expansion and chemoresistance via regulating SIRT1	5
The role of interleukin 17 in cancer: a systematic review	5
Ginseng mediates its anticancer activity by inhibiting the expression of DNMTs and reactivating methylation-silenced genes in colorectal cancer	5
Advanced glycation end products promote the progression of endometrial cancer via activating the RAGE/CHKA/PI3K/AKT signaling pathway	5
Wild-type p53 suppresses formin-binding protein-17 (FBP17) to reduce invasion	5
Mutational signatures and increased retrotransposon insertions in xeroderma pigmentosum variant skin tumors	5
Cancer-associated fibroblasts-derived exosome-mediated transfer of miR-345-5p promotes the progression of colorectal cancer by targeting CDKN1A	5
The evolving role for surgery in pancreatic cancer	5
Intratumoral microbiota: new frontiers in tumor immunity	5
Exosomal microRNA-23b-3p promotes tumor angiogenesis and metastasis by targeting PTEN in salivary adenoid cystic carcinoma	5
ETS1 deficiency in macrophages suppresses colorectal cancer progression by reducing the F4/80+TIM4+ macrophage population	5
USO1 isoforms differentially promote liver cancer progression by dysregulating the ER–Golgi network	4
Retraction of: Pro-angiogenesis action of arsenic and its reversal by selenium-derived compounds	4
Correction to: Epigenetic silencing of O6 -methylguanine DNA methyltransferase gene in NiS-transformed cells	4
ACSL4: a double-edged sword target in multiple myeloma, promotes cell proliferation and sensitizes cell to ferroptosis	4
TRIM14 suppressed the progression of NSCLC via hexosamine biosynthesis pathway	4
Editor-in-Chief’s Note—Thank you to Reviewers	4
NFE2L3 promotes tumor progression and predicts a poor prognosis of bladder cancer	4
Genomic landscape of chemical-induced lung tumors under Nrf2 different expression levels	4
Inhibition of lysosomal acid β-glucosidase induces cell apoptosis via impairing mitochondrial clearance in pancreatic cancer	4
Retraction of: Genetic and clinical characteristics of BRCA-associated hereditary breast cancer in the West region of Kazakhstan	4
Sitravatinib combined with PD-1 blockade enhances cytotoxic T-cell infiltration by M2 to M1 tumor macrophage repolarization in esophageal adenocarcinoma	4
Understanding the role of dopamine in cancer: past, present and future	4
The ubiquitin ligase STUB1 suppresses tumorigenesis of renal cell carcinomas through regulating YTHDF1 stability	4
Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression	4
LncRNA CARD8-AS1 suppresses lung adenocarcinoma progression by enhancing TRIM25-mediated ubiquitination of TXNRD1	4
Trefoil factor family 2 inhibits cholangiocarcinogenesis by regulating the PTEN pathway in mice	4
Editor-in-Chief’s Note—Thank you to Reviewers	4
Enhancing carboplatin sensitivity in ovarian cancer cells by blocking the mercapturic acid pathway transporter	4
tRNA-derived fragment tRFLys-CTT-010 promotes triple-negative breast cancer progression by regulating glucose metabolism via G6PC	4
Correction to: Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer	4
tRF-29-79 regulates lung adenocarcinoma progression through mediating glutamine transporter SLC1A5	4
Splicing transcriptome-wide association study to identify splicing events for pancreatic cancer risk	3
USP53 activated by H3K27 acetylation regulates cell viability, apoptosis and metabolism in esophageal carcinoma via the AMPK signaling pathway	3
Dehydroabietylamine exerts antitumor effects by affecting nucleotide metabolism in gastric cancer	3
LncRNA MEG3 suppresses prostate cancer progression by mediating macrophage polarization via the miR-148a-3p/ARRDC3 signaling axis	3
Detection of DNA adducts derived from the tobacco carcinogens, benzo[a]pyrene and dibenzo[def,p]chrysene in human oral buccal cells	3
Effect of vitamin E δ-tocotrienol and aspirin on Wnt signaling in human colon cancer stem cells and in adenoma development in APCmin/+ mice	3
MCM6 promotes intrahepatic cholangiocarcinoma progression by upregulating E2F1 and enhancing epithelial–mesenchymal transition	3
YAP1 activation promotes epithelial–mesenchymal transition and cell survival of renal cell carcinoma cells under shear stress	3
Prognostic impact of tumor-specific insulin-like growth factor binding protein 7 (IGFBP7) levels in breast cancer: a prospective cohort study	3
Gasdermin D represses inflammation-induced colon cancer development by regulating apoptosis	3
Increased acrolein–DNA adducts in buccal brushings of e-cigarette users	3
Smoking and risk of colorectal cancer according to KRAS and BRAF mutation status in a Japanese prospective Study	3
The BET inhibitor GNE-987 effectively induces anti-cancer effects in T-cell acute lymphoblastic leukemia by targeting enhancer regulated genes	3
Age-related macrophage alterations are associated with carcinogenesis of colorectal cancer	3
Increased H2O2 levels and p53 stabilization lead to mitochondrial dysfunction in XPC-deficient cells	3
TERT and BRAF V600E mutations in thyroid cancer of World Trade Center Responders	3
Commentary: Role and communications of cancer hazard determinations	3
Exosomal circPVT1 promotes angiogenesis in laryngeal cancer by activating the Rap1b–VEGFR2 signaling pathway	3
Inhibition of lung adenocarcinoma by combinations of sulfasalazine (SAS) and disulfiram-copper (DSF-Cu) in cell line models and mice	3
Correction to: TCL1A acts as a tumour suppressor by modulating gastric cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop	3
Correction to: Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation	3
PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis	3
Amlodipine, an L-type Ca2+ channel inhibitor, regulates release of extracellular vesicles from tumor cells	3
ARID1Amutations in cancer development: mechanism and therapy	3
Andrew Zloza, MD, PhD (1978–2024)	3
Type-2 cGMP-dependent protein kinase suppresses proliferation and carcinogenesis in the colon epithelium	3
Transcription phenotype of circulating tumor cells in non-metastatic breast cancer	3
Triterpenoid ursolic acid regulates the environmental carcinogen benzo[a]pyrene-driven epigenetic and metabolic alterations in SKH-1 hairless mice for skin cancer interception	3
On the road to colorectal cancer development: crosstalk between the gut microbiota, metabolic reprogramming, and epigenetic modifications	3
The presence of intratumoral Porphyromonas gingivalis correlates with a previously defined pancreatic adenocarcinoma, immune cell expression phenotype and with tumor resident, adaptive immune r	3
Retracted: Genetic and clinical characteristics of BRCA-associated hereditary breast cancer in the West region of Kazakhstan	3
Extracellular vesicles derived from cancer-associated fibroblast carries miR-224-5p targeting SLC4A4 to promote the proliferation, invasion and migration of colorectal cancer cells	3