International Endodontic Journal

Article	Citations
Clinical outcome of guided endodontics versus freehand drilling: Comment	258
Precision‐milled simulated curved root canals in bovine dentine for the assessment of chemo‐mechanical root canal preparation	252
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Substance P/calcitonin gene‐related peptide and their receptors expression in human periodontal ligament after root canal preparation with five different systems	120
Lipopolysaccharides and hydrogen peroxide induce contrasting pathological conditions in dental pulpal cells	109
Transfer Learning From Micro‐ CT to Periapical Radiographs for Three‐Dimensional Root Canal Morphological Identification	91
Targeting hexokinase 1 alleviates NLRP3‐mediated inflammation in apical periodontitis: A laboratory investigation	88
Inflammatory profile of apical periodontitis exacerbated by cigarette smoke inhalation: Histological and immunohistochemical analysis in rats	79
Special Issue: Innovations in Dental Education, International Endodontic Journal	76
IWP‐2 modulates the immunomodulatory properties of human dental pulp stem cells in vitro	73
Top 100 most‐cited scientific articles in regenerative endodontics 2019–2023: A bibliometric analysis	69
Immunomodulatory effect of IL‐1RA in LPS‐activated macrophage/dental pulp stem cells co‐culture	58
Exploring approaches to pulp vitality assessment: A scoping review of nontraditional methods	58
Gender diversity in endodontics: Women's representation at recent biennial meetings	57
Angiogenic and neurogenic potential of dental‐derived stem cells for functional pulp regeneration: A narrative review	54
Pulp Response to Materials Used in the Management of Deep Carious Lesions Without Pulp Exposure: A Systematic Review and Network Meta‐Analysis	51
Activin a regulates vascular formation and stabilization in direct coculture of dental pulp stem cells and endothelial cells	51
Beyond the Evidence: Why Do Clinical Guidelines and Recommendations Differ?	50
The financial and quality of life impact of urgent dental presentations: A cross‐sectional study	50
New consultant statistical advisor	49
Periapical healing following endodontic microsurgery with collagen‐based bone‐filling material: A randomized controlled clinical trial	43
Selenium ameliorates inflammation by decreasing autophagic flux and mitogen‐activated protein kinase signalling on experimentally induced rat periapical lesions	42
Response to the letter regarding our article, ‘Potential predisposing features of external cervical resorption: An observational study’ (Patel et al., 2025)	42
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The use of electrodermal activity in pulpal diagnosis and dental pain assessment	41

Micro‐computed tomographic evaluation of dentinal microcracks in response to progressive taper enlargement in root canals of maxillary molars	40
Expression of chronic pain genes in apical periodontitis tissues	40
Micro‐CT evaluation of a nanodiamond irrigant for hard‐tissue debris removal during sonic agitation	40
In‐depth investigation of FAM20A insufficiency effects on deciduous dental pulp cells: Altered behaviours, osteogenic differentiation, and inflammatory gene expression	40
Effect of Pulpal Haemostasis Time on Partial Pulpotomy Outcome in Cariously Exposed Mature Permanent Teeth With Symptomatic Irreversible Pulpitis	39
Success rate of orthograde endodontic retreatment after failed apicectomy – A retrospective study	39
Four‐Octyl Itaconate Alleviates Enterococcus faecalis ‐Induced Apical Periodontitis by Inhibiting Macrophage M1	38
Influence of Imaging Modality on the Detection of Periapical Lesions in Root‐Filled Teeth: A Systematic Review and Meta‐Analysis	37
Volumetric changes in root canal sealers in ex vivo and a novel animal model approach	37
Influence of dental bleaching on the pulp tissue: A systematic review of in vivo studies	36
NLRP1 as a Novel Pyroptosis Biomarker in Irreversible Pulpitis: A Laboratory Investigation and Animal Model Study	33
Artificial intelligence chatbots in endodontic education—Concepts and potential applications	33
Elevated serum hepatic transaminases in apical periodontitis individuals	32
Shaping ability of new reciprocating or rotary instruments with two cross‐sectional designs: An ex vivo study	31
Modulation of Prickle2 Expression to Facilitate Dentine Formation: A Laboratory Investigation	30
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Dental pulp lymphatic vessel dynamics during tooth development and pulp stimulation in rodents	28
Issue Information	28
Cost‐effectiveness analysis of full versus selective root canal retreatment	27
Efficacy of mixture of injectable‐platelet‐rich fibrin and type‐1 collagen particles on the closure of through‐and‐through periapical bone defects: A randomized controlled trial	27
Global cone‐beam computed tomography adoption, usage and scan interpretation preferences of dentists and endodontists	26
The impact of bone grafting with/without barrier membrane placement on the outcome of apical surgery: A systematic review and meta‐analysis	26
Microenvironmental Challenges in Regenerative Endodontic Procedures: Disinfection, Tissue Engineering and Future Directions	26
Cannabidiol alleviates LPS‐inhibited odonto/osteogenic differentiation in human dental pulp stem cells in vitro	25
Gut microbiota dysbiosis links chronic apical periodontitis to liver fibrosis in nonalcoholic fatty liver disease: Insights from a mouse model	25
Multiple External Invasive Root Resorption and Calcification in Systemic Sclerosis—Case Report	24
Success rate of permanent teeth pulpotomy using bioactive materials: A systematic review and meta‐analysis of randomized clinical trials	24
Quo Vadis?	24
The presence of Enterococcus in root canal infections based on next‐generation sequencing: A systematic review and meta‐analysis	23
The Interplay of M1 Macrophages and Dental Pulp Stem Cells Promotes Angiogenesis Through IL ‐8‐Dep	23
Mitochondrial biogenesis disorder and oxidative damage promote refractory apical periodontitis in rat and human	23
Efficacy of imaging techniques for the diagnosis of apical periodontitis: A systematic review	22
Issue Information	22
Issue Information	22
Critical analysis of the reporting quality of animal studies within Endodontics using the Preferred Reporting Items for Animal Studies in Endodontics (PRIASE) 2021 quality standard checklist	22
A Thermosensitive Gel Containing Biodegradable Nanoparticles Carrying Calcium Hydroxide as Antibacterial Intracanal Therapy	22
Intracanal removal and apical extrusion of filling material after retreatment using rotary or reciprocating instruments: A new approach using human cadavers	22
What does epidemiology tell us about treatment outcomes in endodontics	21
Outcome Following Complete and Partial Pulpotomy in Managing Cariously Exposed Mature Permanent Molars With Symptomatic Irreversible Pulpitis: A 5‐Year Follow‐Up of a Randomised Clinical Trial	21
Multicenter RCT 6‐Year Survival of Zirconia‐Reinforced Lithium Silicate Endocrowns: 90° Shoulder Versus Butt‐Joint Margins	21
TNFSF13B rs9514828 gene polymorphism and soluble B cell activating factor levels: Association with apical periodontitis	21
Exploring Persistent Apical Periodontitis in Humans: Integrative Genetic, Histological and Microbiological Perspectives for Translational Research	21
Viability and oxidative stress of dental pulp cells after indirect application of chemomechanical agents: An in vitro study	21
Assessment of Case Complexity of Root Canal Treatments Using Contemporary Complexity Grading Systems: A Clinical Service Evaluation	21
Proteomic Profiling of Dentinal Fluid for the Identification of Biomarkers in Pulpal Inflammation: An Exploratory Study	21
Outcome of High‐Fidelity 3D Jaw Model Simulations in Enhancing Endodontic Microsurgical Training	21
Effects of phase‐transited lysozyme on adhesion, migration and odontogenic differentiation of human dental pulp cells: An in vitro study	21
Prevalence of apical periodontitis and non‐retention of root‐filled teeth in hypertensive patients: Systematic review and meta‐analysis	21
Benefits of using immersive virtual reality in haptic dental simulation for endodontic access cavity training: A comparative crossover study	20
Issue Information	20

Next‐generation antibacterial nanopolymers for treating oral chronic inflammatory diseases of bacterial origin	20
Quantitative analysis of culturable bacteria, levels of endotoxins, inflammatory mediators and substance P in teeth with symptomatic irreversible pulpitis and in teeth with vital normal pulp tissues	20
Artificial Intelligence Models for Diagnosing Pulpitis in Adults Using a Modified Wolters Classification: A Diagnostic Accuracy Study	20
Issue Information	20
Psychological Assessment of Patients With Apical Periodontitis and Caries: A Case–Control Study	19
Deep‐Learning‐Based Automatic Measurement of the Distance Between the Maxillary Sinus and Maxillary Posterior Teeth on CBCT Images	19
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The ATF4‐regulated LncRNA MALAT1 promotes odontoblastic differentiation of human dental pulp stem cells via histone demethylase JMJD3: An in vitro study	19
Shaping ability of BlueShaper, TruNatomy, DC Taper and HyFlex EDM in long oval canals: An ex vivo study	19
Guanylate‐binding protein 5‐mediated cell‐autonomous immunity suppresses inflammation in dental pulpitis: An in vitro study	19
What is new in the 2023 European Society of Endodontology S3 ‐level clinical practice guidelines?	19
Inflammatory and differentiation cellular response to calcium silicate cements: An in vitro study	19
Advances in scaffolds used forpulp–dentinecomplex tissue engineering: A narrative review	18
Melatonin and the Dental Pulp: A Scoping Review	18
The effect of two different root canal sealers on treatment outcome and post‐obturation pain in single‐visit root canal treatment: A prospective randomized clinical trial	18
Association between apical periodontitis and secondary outcomes of atherosclerotic cardiovascular disease: A case–control study	18
Microbiome of Apical Intracanal and Extraradicular Biofilms From the Same Roots of Teeth With Persistent Apical Periodontitis: An Observational Study	18
Nlrp3 inflammasome drives regulatory T cell depletion to accelerate periapical bone erosion	18
Issue Information	18
Effects of ovariectomy‐induced osteoporosis and two photobiomodulation protocols on the repair of apical periodontitis in Wistar rats: A microCT study	18
Unveiling the ChatGPT phenomenon: Evaluating the consistency and accuracy of endodontic question answers	18
A Protocol for the Development of a New Three‐Dimensional Classification of Dens Invaginatus Using Cone Beam Computed Tomography Imaging	18
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Fibroblast Dysregulation in Multiple Idiopathic External Cervical Resorption: Laboratory Investigation From a Rare Case of 13 Affected Teeth	17
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The employment of recommended root canal treatment procedures by dentists in Croatia and the Czech Republic	17
Comparative analysis of deep dentinal caries microbiota in teeth with normal pulp, reversible pulpitis, symptomatic and asymptomatic irreversible pulpitis	17
Tooth survival after endodontic treatment	17
The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation	16
Cytotoxicity, biocompatibility and osteoinductive profile of an MTA‐hydrogel‐based cement: An in vitro and animal study	16
Association between endodontic, patient‐related factors and severe odontogenic infections; a South Australian retrospective audit	16
Extracellular vesicles of Candida albicans show dual effects on Enterococcus faecalis growth and virulence: A laboratory‐based investigation	16
Hsa‐miR‐27b‐5p suppresses the osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth via targeting BMPR1A: An ex vivo study	16
Injectable Thermo‐Responsive Dentine Matrix Hydrogel for Enhancing Dentine Regeneration	16
Effect of Oral Corticosteroid Premedication on the Success of Anaesthetising Mandibular Teeth With Irreversible Pulpitis: A Systematic Review With Meta‐Analysis and Trial Sequential Analysis of Random	16
Proanthocyanidin surface preconditioning of dental pulp stem cell spheroids enhances dimensional stability and biomineralization in vitro	16
Protocol for the Development of a New Comprehensive Classification for Iatrogenic Tooth Perforations	16
Prevalence and Predisposing Factors of Periapical Mucositis: A Cross‐Sectional Study	15
Unveiling the ChatGPT phenomenon: Evaluating the consistency and accuracy of endodontic question answers	15
Feasibility and Precision of Robot‐Assisted Autotransplantation of Teeth: An In Vitro Study	15
The use of coaching to enhance students' learning, self‐efficacy and performance in endodontics	15
Outcome of partial and full pulpotomy in cariously exposed mature molars with symptoms indicative of irreversible pulpitis: A randomized controlled trial	15
Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model	15
A New Biological Perspective in Vital Pulp Therapy: The Potential Role of Innate Immune Memory in Modulating Healing Outcomes	15
Construction of Preoperative Diagnostic Model of Periapical Cyst by Multiparameter Magnetic Resonance Imaging: A Pilot Study	14
Innovative Didactic Learning Formats: Have They Improved Dental Education? A Systematic Review and Meta‐Analysis	14
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Intracellular bacterial eradication using a novel peptide in vitro	14
Evaluation of the transdentinal capability of the intrinsic antibacterial cetylpyridinium chloride/cholesterol sterosomes in vitro and in vivo	14
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Melatonin decreases plasma TNF‐α and improves nonenzymatic antioxidant defence and insulin sensitivity in rats with apical periodontitis fed a high‐fat diet	14
Bayesian Hierarchical Modelling of Root Canal Morphology in Mandibular First Premolars Across 21 Countries	14
Abstracts	14
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PRIDASE 2024 guidelines for reporting diagnostic accuracy studies in endodontics: A consensus‐based development	13
Patient‐related outcomes and Oral Health‐Related Quality of Life in endodontics	13
When Novelty Outpaces Evidence: Social Media as an Unregulated Force Propelling Innovation in Endodontics: A Narrative Review	13
Inflammatory microenvironment of moderate pulpitis enhances the osteo‐/odontogenic potential of dental pulp stem cells by autophagy	13
Calcium hydroxide‐loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicament	13
Multispecies Biofilms Treated With Endodontic Sealers or Calcium Hydroxide: Antimicrobial Activity and Changes in Community Composition	13
The efficacy of premixed bioceramic sealers versus standard sealers on root canal treatment outcome, extrusion rate and post‐obturation pain: A systematic review and meta‐analysis	13
Comments on the Evidentiary Framework of the EFCD‐ESE‐ORCA Guideline on Deep Caries Management	13
Explaining the working mechanism of laser‐activated irrigation and its action on microbial biofilms: A high‐speed imaging study	13
RE: The Survival and Success of Teeth With External Cervical Resorption: A Multi‐Centre, Retrospective Study	13
The effectiveness of partial pulpotomy compared with full pulpotomy in managing deep caries in vital permanent teeth with a diagnosis of non‐traumatic pulpitis	13
The outcome of full and deep pulpotomy in teeth with extremely deep carious lesion and symptomatic irreversible pulpitis: A non‐inferiority randomized controlled trial	12
Development and preliminary validation of an Objective Structured Assessment of Technical Skills (OSATS) for a partial pulpotomy procedure	12
Case complexity of root canal treatments accepted for training in a secondary care setting assessed by three complexity grading systems: A service evaluation	12
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Pre‐medical assessment of root–canal–filled teeth with asymptomatic apical periodontitis—A multifaceted balancing act	12
Diagnosis consensus among endodontic specialists and general practitioners: An international survey and a proposed modification to the current diagnostic terminology	12
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Well‐being, postoperative pain and outcome after clinical application of a novel root canal irrigation fluid—RISA—in teeth with apical periodontitis: A first‐in‐human study	12
From pulp to cementum: 3D visualization of soft and hard dental tissues using different ex vivo nano‐ CT	12
Response to Letter to the Editor	12
N‐Acetylcysteine Reduces Alveolar Bone Loss and Mitigates Systemic Oxidative Damage in Rats With Apical Periodontitis	12
The Clinical Impact of the Combination of CBCT and Periapical Radiographs on Endodontic Diagnosis and Treatment Planning—A Retrospective Cohort Study	12
Issue Information	12
Minimally Invasive Vertical Incision Subperiosteal Tunnelling Technique for Targeted Endodontic Surgery: Technical Overview and a Case Report	12

TLR ‐2 gene methylation in peripheral blood monocytes from apical periodontitis individuals: A cross‐sectional study	12
Characterization of the file‐specific heat‐treated ProTaper Ultimate rotary system	12
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The expression of cyclic GMP–AMP synthase in human apical periodontitis: A laboratory investigation	11
Clinical and radiographic outcomes of regenerative endodontic procedures for traumatized permanent necrotic teeth with apical periodontitis and external root resorption	11
Characterization of nano‐hydroxyapatite incorporated carboxymethyl chitosan composite on human dental pulp stem cells	11
An international consensus study to identify “what” outcomes should be included in a core outcome set for endodontic treatments (COSET) for utilization in clinical practice and research	11
Issue Information	11
Fibre Post Removal Using Dynamic Navigation System and Autonomous Robotic System: An In Vitro Study	11
Prevalence, Classification and Factors Associated With Cemental Tears—A Retrospective Observational Cross‐Sectional Study in a Postgraduate Endodontic Clinic	11
Symptom correlation and spatial distribution of inflammatory mediators in pulpitis—A preliminary study	11
Multimethod analysis of large‐ and low‐tapered single file reciprocating instruments: Design, metallurgy, mechanical performance, and irrigation flow	11
Osteopontin interacts with dendritic cells and macrophages in pulp inflammation: Comprehensive transcriptomic analysis and laboratory investigations	11
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Advancing insights in contemporary endodontics: Proposing a multimethod approach for comprehensive evaluation of NiTi instruments	11
Effect of light‐cured pulp capping materials on human dental pulp cells in vitro	11
In vitro response of dental pulp stem cells to dural substitute grafts: Analysis of cytocompatibility and bioactivity	11
Cytocompatibility and bioactive potential of AH Plus Bioceramic Sealer: An in vitro study	11
Full Working Length Negotiation in Challenging Narrow Canals Using a Single Conservative Asymmetric Reciprocating Instrument	11
Sympathetic nerves inhibit dental pulp stem cell differentiation and tertiary dentine formation via α1B‐adrenergic receptor	11
Association between single‐nucleotide polymorphisms in serotonin receptor 2A and melatonin receptor 1A genes and pain after root canal treatment	11
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Apical periodontitis as an aggravating factor for the severity of rheumatoid arthritis: An animal study	10
Dentine thickness in maxillary fused molars depends on the fusion type: An ex vivo micro‐computed tomography study	10
CXCR2 + Neutrophils Drive Neutrophil Extracellular Traps Formation and Exacerbate Pulpitis in Rats: An In Vitro and In Vivo Laboratory Inv	10
Teaching of magnification in the undergraduate curriculum: A position statement from the British Endodontic Society Teachers of Endodontology Group	10
Biological evaluation of novel phosphorylated pullulan‐based calcium hydroxide formulations as direct pulp capping materials: An in vivo study on a rat model	10
Abstract	10
Molecular biomarkers for objective assessment of symptomatic pulpitis: A systematic review and meta‐analysis	10
Decellularized Dental Pulp Matrix Hydrogel Promotes Functional Endodontic Regeneration In Situ	10
Mamba‐Based Deep Learning Model for Automated Periapical Index Classification Using Periapical Radiographs and Clinical Metadata	10
Multiple cell death modalities and immune response in pulpitis	10
The detection of apical radiolucencies in periapical radiographs: A comparison between an artificial intelligence platform and expert endodontists with CBCT serving as the diagnostic benchmark	10
Impact of root canal disinfection on the bacteriome present in primary endodontic infection: A next generation sequencing study	10
The Efficacy of Intracanal Medicaments Within the Regenerative Endodontic Procedures on Permanent Necrotic Immature Teeth: Systematic Review and Naïve Indirect‐Comparison Meta‐Analysis	9
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A Wet‐and‐Dry Research Model: Unveiling Biomechanics in Odontoblast Polarization	9
Comprehensive Comparative Analysis of the Efficiency of Two Clearing Agents in Natural Transparent Teeth Preparation for Dental Education	9
Deep Learning for Assessing Caries Depth in Permanent Teeth Using Intraoral Radiographs: A Systematic Review	9
Enhancing the Quality of Single Cone Obturation Using Hydroxyapatite Precursor Grafted Nanocomplex for Dentine Conditioning: An In Vitro Study	9
Axin2‐CreERT2 mediated knockout of bone morphogenetic protein receptor type 1A caused abnormal secondary dentine and altered cell fate of Axin2‐expressing odontogenic cells	9
A video‐based decision aid improved knowledge and decreased decisional conflict for asymptomatic persistent endodontic lesions	9
Issue Information	9
XP‐Endo Finisher behaviour and irrigant temperature in intracanal environment: Clinical measurements	9
Post‐operative pain in non‐surgical root canal treatment after sealer‐based obturation versus warm vertical compaction: A randomized clinical trial	9
Experimental validation of a computational fluid dynamics model using micro‐particle image velocimetry of the irrigation flow in confluent canals	9
Intentional Negotiation and Filling of Accessory Canals: A Case Series With Three‐Dimensional Segmentation and Volumetric Healing Assessment	9
Impact of Haptic Simulators and 3D ‐Printed Teeth on Dental Students' Self‐Assessment of Endodontic Access Cavities: A Comparative Pilot Study	9
Machine Learning Model for Predicting Postoperative Pain in Cases of Irreversible Pulpitis	9
A comparison of radiographically determined periapical healing and tooth survival outcomes of root canal (re)treatment performed in two care pathways within the United Kingdom Armed Forces	9
The N6‐methyladenosine demethylase FTO is required for odontoblast differentiation in vitro and dentine formation in mice by promoting RUNX2 exon 5 inclusion through RBM4	9