International Endodontic Journal

Article	Citations
Clinical outcome of guided endodontics versus freehand drilling: Comment	271
Inflammatory profile of apical periodontitis exacerbated by cigarette smoke inhalation: Histological and immunohistochemical analysis in rats	219
Lipopolysaccharides and hydrogen peroxide induce contrasting pathological conditions in dental pulpal cells	184
A critical analysis of research methods and experimental models to study irrigants and irrigation systems	172
Effect of kinematics on the torque/force generation, surface characteristics, and shaping ability of a nickel‐titanium rotary glide path instrument: An ex vivo study	143
Precision‐milled simulated curved root canals in bovine dentine for the assessment of chemo‐mechanical root canal preparation	111
	97
Activin a regulates vascular formation and stabilization in direct coculture of dental pulp stem cells and endothelial cells	96
Substance P/calcitonin gene‐related peptide and their receptors expression in human periodontal ligament after root canal preparation with five different systems	90
Immunomodulatory effect of IL‐1RA in LPS‐activated macrophage/dental pulp stem cells co‐culture	89
The financial and quality of life impact of urgent dental presentations: A cross‐sectional study	88
Targeting hexokinase 1 alleviates NLRP3‐mediated inflammation in apical periodontitis: A laboratory investigation	84
Exploring approaches to pulp vitality assessment: A scoping review of nontraditional methods	80
Gender diversity in endodontics: Women's representation at recent biennial meetings	77
IWP‐2 modulates the immunomodulatory properties of human dental pulp stem cells in vitro	73
Angiogenic and neurogenic potential of dental‐derived stem cells for functional pulp regeneration: A narrative review	71
New consultant statistical advisor	70
Top 100 most‐cited scientific articles in regenerative endodontics 2019–2023: A bibliometric analysis	70
Periapical healing following endodontic microsurgery with collagen‐based bone‐filling material: A randomized controlled clinical trial	68
Micro‐computed tomographic evaluation of dentinal microcracks in response to progressive taper enlargement in root canals of maxillary molars	66
The use of electrodermal activity in pulpal diagnosis and dental pain assessment	63
Response to the letter regarding our article, ‘Potential predisposing features of external cervical resorption: An observational study’ (Patel et al., 2025)	62
In‐depth investigation of FAM20A insufficiency effects on deciduous dental pulp cells: Altered behaviours, osteogenic differentiation, and inflammatory gene expression	59
Micro‐CT evaluation of a nanodiamond irrigant for hard‐tissue debris removal during sonic agitation	59
Influence of dental bleaching on the pulp tissue: A systematic review of in vivo studies	57

Volumetric changes in root canal sealers in ex vivo and a novel animal model approach	56
Expression of chronic pain genes in apical periodontitis tissues	55
Selenium ameliorates inflammation by decreasing autophagic flux and mitogen‐activated protein kinase signalling on experimentally induced rat periapical lesions	55
Influence of ethylenediaminetetraacetic acid on regenerative endodontics: A systematic review	50
Present status and future directions—Vital pulp treatment and pulp preservation strategies	50
Success rate of orthograde endodontic retreatment after failed apicectomy – A retrospective study	49
Intracanal removal and apical extrusion of filling material after retreatment using rotary or reciprocating instruments: A new approach using human cadavers	48
Gut microbiota dysbiosis links chronic apical periodontitis to liver fibrosis in nonalcoholic fatty liver disease: Insights from a mouse model	47
Dental pulp lymphatic vessel dynamics during tooth development and pulp stimulation in rodents	46
Modulation of Prickle2 Expression to Facilitate Dentine Formation: A Laboratory Investigation	46
Issue Information	46
Efficacy of mixture of injectable‐platelet‐rich fibrin and type‐1 collagen particles on the closure of through‐and‐through periapical bone defects: A randomized controlled trial	44
Elevated serum hepatic transaminases in apical periodontitis individuals	40
A Thermosensitive Gel Containing Biodegradable Nanoparticles Carrying Calcium Hydroxide as Antibacterial Intracanal Therapy	39
Single nucleotide polymorphisms as a predisposing factor for the development of apical periodontitis—An umbrella review	38
Outcome of full pulpotomy in mature permanent molars using 3 calcium silicate‐based materials: A parallel, double blind, randomized controlled trial	38
Success rate of permanent teeth pulpotomy using bioactive materials: A systematic review and meta‐analysis of randomized clinical trials	38
Cost‐effectiveness analysis of full versus selective root canal retreatment	38
Shaping ability of new reciprocating or rotary instruments with two cross‐sectional designs: An ex vivo study	38
Efficacy of imaging techniques for the diagnosis of apical periodontitis: A systematic review	37
Cannabidiol alleviates LPS‐inhibited odonto/osteogenic differentiation in human dental pulp stem cells in vitro	34
	34
Mitochondrial biogenesis disorder and oxidative damage promote refractory apical periodontitis in rat and human	34
The presence of Enterococcus in root canal infections based on next‐generation sequencing: A systematic review and meta‐analysis	32
Issue Information	32
Type 2 diabetes and the clinically normal pulp: An in vitro study	32
Global cone‐beam computed tomography adoption, usage and scan interpretation preferences of dentists and endodontists	32
Present status and future directions: vertical root fractures in root filled teeth	31
Present status and future directions: Managing endodontic emergencies	31
Artificial intelligence chatbots in endodontic education—Concepts and potential applications	30
Outcome Following Complete and Partial Pulpotomy in Managing Cariously Exposed Mature Permanent Molars With Symptomatic Irreversible Pulpitis: A 5‐Year Follow‐Up of a Randomised Clinical Trial	29
The impact of bone grafting with/without barrier membrane placement on the outcome of apical surgery: A systematic review and meta‐analysis	29
Issue Information	29
Editor‐in‐Chief thanks the Associate Editors, Editorial Board and Referees	29
Issue Information	28
Prevalence of apical periodontitis and non‐retention of root‐filled teeth in hypertensive patients: Systematic review and meta‐analysis	28
Viability and oxidative stress of dental pulp cells after indirect application of chemomechanical agents: An in vitro study	28
Effects of phase‐transited lysozyme on adhesion, migration and odontogenic differentiation of human dental pulp cells: An in vitro study	28
Quantitative analysis of culturable bacteria, levels of endotoxins, inflammatory mediators and substance P in teeth with symptomatic irreversible pulpitis and in teeth with vital normal pulp tissues	27
Next‐generation antibacterial nanopolymers for treating oral chronic inflammatory diseases of bacterial origin	27
Critical analysis of the reporting quality of animal studies within Endodontics using the Preferred Reporting Items for Animal Studies in Endodontics (PRIASE) 2021 quality standard checklist	27
Benefits of using immersive virtual reality in haptic dental simulation for endodontic access cavity training: A comparative crossover study	26
Assessment of Case Complexity of Root Canal Treatments Using Contemporary Complexity Grading Systems: A Clinical Service Evaluation	26
Proteomic Profiling of Dentinal Fluid for the Identification of Biomarkers in Pulpal Inflammation: An Exploratory Study	26
Artificial Intelligence Models for Diagnosing Pulpitis in Adults Using a Modified Wolters Classification: A Diagnostic Accuracy Study	26
Outcome of High‐Fidelity 3D Jaw Model Simulations in Enhancing Endodontic Microsurgical Training	25
What does epidemiology tell us about treatment outcomes in endodontics	25
Methodological assessment and overall confidence in the results of systematic reviews with network meta‐analyses in Endodontics	24
TNFSF13B rs9514828 gene polymorphism and soluble B cell activating factor levels: Association with apical periodontitis	24
Anaesthetic efficacy of incorporating different additives into lidocaine for the inferior alveolar nerve block: A systematic review with meta‐analysis and trial sequential analysis	24

Issue Information	24
A critical analysis of clinical research methods to study regenerative endodontics	24
Association between apical periodontitis and secondary outcomes of atherosclerotic cardiovascular disease: A case–control study	23
The ATF4‐regulated LncRNA MALAT1 promotes odontoblastic differentiation of human dental pulp stem cells via histone demethylase JMJD3: An in vitro study	23
What is new in the 2023 European Society of Endodontology S3‐level clinical practice guidelines?	23
Issue Information	23
Comparative analysis of deep dentinal caries microbiota in teeth with normal pulp, reversible pulpitis, symptomatic and asymptomatic irreversible pulpitis	23
Inflammatory and differentiation cellular response to calcium silicate cements: An in vitro study	23
A Protocol for the Development of a New Three‐Dimensional Classification of Dens Invaginatus Using Cone Beam Computed Tomography Imaging	23
Effects of ovariectomy‐induced osteoporosis and two photobiomodulation protocols on the repair of apical periodontitis in Wistar rats: A microCT study	23
Guanylate‐binding protein 5‐mediated cell‐autonomous immunity suppresses inflammation in dental pulpitis: An in vitro study	22
Advances in scaffolds used forpulp–dentinecomplex tissue engineering: A narrative review	22
Nlrp3 inflammasome drives regulatory T cell depletion to accelerate periapical bone erosion	22
A critical review ofin vitroresearch methodologies used to study mineralization in human dental pulp cell cultures	22
Tooth survival after endodontic treatment	22
The effect of two different root canal sealers on treatment outcome and post‐obturation pain in single‐visit root canal treatment: A prospective randomized clinical trial	22
	21
Unveiling the ChatGPT phenomenon: Evaluating the consistency and accuracy of endodontic question answers	21
Proanthocyanidin surface preconditioning of dental pulp stem cell spheroids enhances dimensional stability and biomineralization in vitro	21
Shaping ability of BlueShaper, TruNatomy, DC Taper and HyFlex EDM in long oval canals: An ex vivo study	21
	21
The employment of recommended root canal treatment procedures by dentists in Croatia and the Czech Republic	20
Evaluation of the transdentinal capability of the intrinsic antibacterial cetylpyridinium chloride/cholesterol sterosomes in vitro and in vivo	20
Extracellular vesicles of Candida albicans show dual effects on Enterococcus faecalis growth and virulence: A laboratory‐based investigation	19
Cytotoxicity, biocompatibility and osteoinductive profile of an MTA‐hydrogel‐based cement: An in vitro and animal study	19
Association between endodontic, patient‐related factors and severe odontogenic infections; a South Australian retrospective audit	19
Unveiling the ChatGPT phenomenon: Evaluating the consistency and accuracy of endodontic question answers	19
Instrumentation kinematics does not affect bacterial reduction, post‐operative pain, and flare‐ups: A randomized clinical trial	19
The use of coaching to enhance students' learning, self‐efficacy and performance in endodontics	18
Exosomes derived from stem cells from the apical papilla alleviate inflammation in rat pulpitis by upregulating regulatory T cells	18
Fibroblast Dysregulation in Multiple Idiopathic External Cervical Resorption: Laboratory Investigation From a Rare Case of 13 Affected Teeth	18
Hsa‐miR‐27b‐5p suppresses the osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth via targeting BMPR1A: An ex vivo study	18
Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model	18
Outcome of single‐ versus two‐visit root canal retreatment in teeth with periapical lesions: A randomized clinical trial	18
Outcome of partial and full pulpotomy in cariously exposed mature molars with symptoms indicative of irreversible pulpitis: A randomized controlled trial	17
A critical analysis of research methods and experimental models to study biocompatibility of endodontic materials	17
Abstracts	16
	16
	16
	16
Innovative Didactic Learning Formats: Have They Improved Dental Education? A Systematic Review and Meta‐Analysis	16
Melatonin decreases plasma TNF‐α and improves nonenzymatic antioxidant defence and insulin sensitivity in rats with apical periodontitis fed a high‐fat diet	16
Issue Information	16
Editorial	16
	16
Periapical and endodontic status of patients with inflammatory bowel disease: Age‐ and sex‐matched case–control study	16
Patient‐related outcomes and Oral Health‐Related Quality of Life in endodontics	15
The efficacy of premixed bioceramic sealers versus standard sealers on root canal treatment outcome, extrusion rate and post‐obturation pain: A systematic review and meta‐analysis	15
Calcium hydroxide‐loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicament	15
Diagnosis consensus among endodontic specialists and general practitioners: An international survey and a proposed modification to the current diagnostic terminology	15
External cervical resorption – Treatment outcomes and determinants: A retrospective cohort study with up to 10 years of follow‐up	15
The effectiveness of partial pulpotomy compared with full pulpotomy in managing deep caries in vital permanent teeth with a diagnosis of non‐traumatic pulpitis	15
Patient record assessment of results and related resources spent during 1 year after initiation of root canal treatment in a Swedish public dental organization	15
The outcome of full and deep pulpotomy in teeth with extremely deep carious lesion and symptomatic irreversible pulpitis: A non‐inferiority randomized controlled trial	15
Growth factor release and dental pulp stem cell attachment following dentine conditioning: An in vitro study	15
Explaining the working mechanism of laser‐activated irrigation and its action on microbial biofilms: A high‐speed imaging study	15
PRIDASE 2024 guidelines for reporting diagnostic accuracy studies in endodontics: A consensus‐based development	15
Inflammatory microenvironment of moderate pulpitis enhances the osteo‐/odontogenic potential of dental pulp stem cells by autophagy	15
Multispecies Biofilms Treated With Endodontic Sealers or Calcium Hydroxide: Antimicrobial Activity and Changes in Community Composition	14
Issue Information	14
	14
Intracellular bacterial eradication using a novel peptide in vitro	14
From pulp to cementum: 3D visualization of soft and hard dental tissues using different ex vivo nano‐CT contrast‐enhancement techniques	14
The Clinical Impact of the Combination of CBCT and Periapical Radiographs on Endodontic Diagnosis and Treatment Planning—A Retrospective Cohort Study	14
	14
TLR‐2 gene methylation in peripheral blood monocytes from apical periodontitis individuals: A cross‐sectional study	14
Multimethod analysis of large‐ and low‐tapered single file reciprocating instruments: Design, metallurgy, mechanical performance, and irrigation flow	13
Well‐being, postoperative pain and outcome after clinical application of a novel root canal irrigation fluid—RISA—in teeth with apical periodontitis: A first‐in‐human study	13
Symptom correlation and spatial distribution of inflammatory mediators in pulpitis—A preliminary study	13
The expression of cyclic GMP–AMP synthase in human apical periodontitis: A laboratory investigation	13
In vitro response of dental pulp stem cells to dural substitute grafts: Analysis of cytocompatibility and bioactivity	13
An international consensus study to identify “what” outcomes should be included in a core outcome set for endodontic treatments (COSET) for utilization in clinical practice and research	13
Osteopontin interacts with dendritic cells and macrophages in pulp inflammation: Comprehensive transcriptomic analysis and laboratory investigations	13
A critical analysis of research methods and experimental models to study the root canal microbiome	13
Pre‐medical assessment of root–canal–filled teeth with asymptomatic apical periodontitis—A multifaceted balancing act	13
Development and preliminary validation of an Objective Structured Assessment of Technical Skills (OSATS) for a partial pulpotomy procedure	13
Minimally Invasive Vertical Incision Subperiosteal Tunnelling Technique for Targeted Endodontic Surgery: Technical Overview and a Case Report	13
Case complexity of root canal treatments accepted for training in a secondary care setting assessed by three complexity grading systems: A service evaluation	13
Effect of light‐cured pulp capping materials on human dental pulp cells in vitro	13
Characterization of nano‐hydroxyapatite incorporated carboxymethyl chitosan composite on human dental pulp stem cells	12

Teaching of magnification in the undergraduate curriculum: A position statement from the British Endodontic Society Teachers of Endodontology Group	12
	12
Clinical and radiographic outcomes of regenerative endodontic procedures for traumatized permanent necrotic teeth with apical periodontitis and external root resorption	12
Present status and future directions: The restoration of root filled teeth	12
Issue Information	12
Apical periodontitis as an aggravating factor for the severity of rheumatoid arthritis: An animal study	12
Characterization of the file‐specific heat‐treated ProTaper Ultimate rotary system	12
A critical analysis of research methods and experimental models to study tooth discolouration from endodontic materials	12
	12
Sympathetic nerves inhibit dental pulp stem cell differentiation and tertiary dentine formation via α1B‐adrenergic receptor	12
A critical analysis of research methods and experimental models to study apical extrusion of debris and irrigants	12
Cytocompatibility and bioactive potential of AH Plus Bioceramic Sealer: An in vitro study	12
Dentine thickness in maxillary fused molars depends on the fusion type: An ex vivo micro‐computed tomography study	11
Predictors of societal and professional impact of Endodontology research articles: A multivariate scientometric analysis	11
Issue Information	11
Influence of different endodontic treatment protocols on tooth survival: A retrospective cohort study with multistate analysis and group balancing	11
Association between single‐nucleotide polymorphisms in serotonin receptor 2A and melatonin receptor 1A genes and pain after root canal treatment	11
Patients with persistent idiopathic dentoalveolar pain in dental practice	11
Advancing insights in contemporary endodontics: Proposing a multimethod approach for comprehensive evaluation of NiTi instruments	11
	11
Biological evaluation of novel phosphorylated pullulan‐based calcium hydroxide formulations as direct pulp capping materials: An in vivo study on a rat model	11
Multiple cell death modalities and immune response in pulpitis	11
The detection of apical radiolucencies in periapical radiographs: A comparison between an artificial intelligence platform and expert endodontists with CBCT serving as the diagnostic benchmark	11
Prevalence, Classification and Factors Associated With Cemental Tears—A Retrospective Observational Cross‐Sectional Study in a Postgraduate Endodontic Clinic	11
Impact of root canal disinfection on the bacteriome present in primary endodontic infection: A next generation sequencing study	11
	11
Enhancing the Quality of Single Cone Obturation Using Hydroxyapatite Precursor Grafted Nanocomplex for Dentine Conditioning: An In Vitro Study	11
Molecular biomarkers for objective assessment of symptomatic pulpitis: A systematic review and meta‐analysis	11
Hypercitrullination and anti‐citrullinated protein antibodies in chronic apical periodontitis, a laboratory investigation. Does autoimmunity contribute to the pathogenesis?	10
Comprehensive Comparative Analysis of the Efficiency of Two Clearing Agents in Natural Transparent Teeth Preparation for Dental Education	10
Impact of Haptic Simulators and 3D‐Printed Teeth on Dental Students' Self‐Assessment of Endodontic Access Cavities: A Comparative Pilot Study	10
XP‐Endo Finisher behaviour and irrigant temperature in intracanal environment: Clinical measurements	10
Exploring deep caries management and barriers to the use of vital pulp treatments by primary care dental practitioners	10
Factors Affecting Root Canal Treatment Case Difficulty, Practitioner Rating of Difficulty and Treatment Complications Among General Dentists and Endodontists: A Prospective Cohort Study From National	10
The N6‐methyladenosine demethylase FTO is required for odontoblast differentiation in vitro and dentine formation in mice by promoting RUNX2 exon 5 inclusion through RBM4	10
Experimental validation of a computational fluid dynamics model using micro‐particle image velocimetry of the irrigation flow in confluent canals	10
Experimental borosilicate bioactive glasses: Pulp cells cytocompatibility and mechanical characterization	10
A video‐based decision aid improved knowledge and decreased decisional conflict for asymptomatic persistent endodontic lesions	10
Axin2‐CreERT2 mediated knockout of bone morphogenetic protein receptor type 1A caused abnormal secondary dentine and altered cell fate of Axin2‐expressing odontogenic cells	10
	10
Effectiveness of endodontic tissue engineering in treatment of apical periodontitis: A systematic review	10
A comparison of radiographically determined periapical healing and tooth survival outcomes of root canal (re)treatment performed in two care pathways within the United Kingdom Armed Forces	10
	9
	9
Exploring Relationships Within the Microbiome of Root Canal Infections and the Influence of Associated Clinical Parameters	9
Chemical and in vivo analyses of calcium silicate‐based materials in bone and connective tissues	9
FoxO1 mediates odontoblast differentiation of hDPSCs via B cell‐derived ANGPTL1 in dental caries: A laboratory investigation	9
A Critical Review of In Vitro Methodologies for Studying Inflammatory Responses in Human Dental Pulp Cell Cultures	9
Present status and future directions—Mechanisms and management of local anaesthetic failures	9
Issue Information	9
Issue Information	9
	9
Characterization and ex vivo modelling of endodontic infections from the Arabian Gulf region	9
The root canal microbiome diversity and function. A whole‐metagenome shotgun analysis	9
A comparison of traditional and virtual reality haptic simulator approaches in preclinical endodontic training: Impacts on skill acquisition, confidence and stress	9
Issue Information	9
Immunohistochemical evaluation of cyclooxygenase‐2 and mast cell density in periapical lesions	9
Evaluation of postoperative pain and healing following regenerative endodontics using platelet‐rich plasma versus conventional endodontic treatment in necrotic mature mandibular molars with chronic pe	9
New Editor‐in‐Chief of the International Endodontic Journal	9
	9
	9
Biocompatibility and bioactive potential of NeoPUTTY calcium silicate‐based cement: An in vivo study in rats	9
What does not form after accidental sodium hypochlorite contact with chlorhexidine?	9
Impact of several NiTi‐thermally treated instrumentation systems on biomechanical preparation of curved root canals in extracted mandibular molars	9
Factors that affect the outcomes of root canal treatment and retreatment—A reframing of the principles	9
Post‐operative pain in non‐surgical root canal treatment after sealer‐based obturation versus warm vertical compaction: A randomized clinical trial	9
Issue Information	9
The IL‐1β‐p65 axis stimulates quiescent odontogenic epithelial cell rests via TGF‐β signalling to promote cell proliferation of the lining epithelia in radicular cysts: A laborat	8
Issue Information	8
Editor‐in‐Chief thanks the associate editors, editorial board and referees	8
Effectiveness of diagnosing pulpitis: A systematic review	8
An In Vitro Investigation of the Impact of Ultrasound Induced‐Streaming Motions on the Flow Inside Lateral Features of the Root Canal	8
Taxonomic abundance in primary and secondary root canal infections	8
The impact of blade geometry (nonflat, flat or hybrid) and metallurgical composition on the mechanical performance of NiTi endodontic instruments: A multimethod laboratory study	8
The use of 0.5% or 3% NaOCl for irrigation during root canal treatment results in similar clinical outcome: A 6‐year follow‐up of a quasi‐randomized clinical trial	8
	8
Reduced C‐reactive protein levels after root canal treatment in clinically healthy young apical periodontitis individuals at cardiovascular risk. A prospective study	8
Lipopolysaccharides from Porphyromonas endodontalis and Porphyromonas gingivalis promote angiogenesis via Toll‐like‐receptors 2 and 4 pathways in vitro	8
Discriminatory performance of the pulpal inflammatory biomarkers; Interleukin‐8 and TNF‐α in patients with symptoms indicative of reversible and irreversible pulpitis: A diagnostic accuracy	8
Efficacy of Combined Versus Supplementary Injection Techniques With Inferior Alveolar Nerve Block for Mandibular Molars With Symptomatic Irreversible Pulpitis: A Systematic Review and Network Meta‐Ana	8
A critical look at outcome measures: Comparison between four dental research journals by use of a hierarchical model	8
Issue Information	8
Special issue: Next‐generation antimicrobial strategies in endodontics	8
Treatment outcomes of regenerative endodontic therapy in immature permanent teeth with pulpal necrosis: A systematic review and network meta‐analysis	8
RGS10 negatively regulates apical periodontitis via TFEB‐mediated autophagy in BABL/c mice model and in vitro	8
Principle and antimicrobial efficacy of laser‐activated irrigation: A narrative review	8
Perceptions and Procedural Errors in the Use of a Patient‐Specific 3D‐Printed Model for MTA Apexification Technique Training	8
Nano eggshell‐based slurry as a direct pulp‐capping material: In vitro characterization and histopathological assessment in an experimental animal model	8
Laboratory Investigation of Lipid Metabolic Reprogramming in Pulpitis: The Linolenic Acid–FASN–NR4A1 Axis in Modulating Dental Pulp Inflammation	7
New associate editor for biological studies	7
Assessing the fatigue resistance of NiTi instruments: A DSC‐based approach to understanding temperature effects	7
Redefining Root Canal Shaping: From Size to Volume—The Functional Endodontic Volume Concept	7
Long‐term prognosis for teeth with external cervical resorption based on periapical images and cone beam CT: A clinical study	7
New Associate Editor for microbiology and irrigation studies	7
Abstracts	7