OOIR: Observatory of International Research

Papers

(The H4-Index of Biomaterials is 88. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy	525
ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds	475
Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment	281
Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization	279
Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties	249
A physicochemical double cross-linked multifunctional hydrogel for dynamic burn wound healing: shape adaptability, injectable self-healing property and enhanced adhesion	240
M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages	230
A novel “hot spring”-mimetic hydrogel with excellent angiogenic properties for chronic wound healing	223
Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration	213
Extracellular vesicles: A bright star of nanomedicine	209
Microfluidic formulation of nanoparticles for biomedical applications	196
4D-bioprinted silk hydrogels for tissue engineering	186
Gene-engineered exosomes-thermosensitive liposomes hybrid nanovesicles by the blockade of CD47 signal for combined photothermal therapy and cancer immunotherapy	185
The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration	174
Injectable Mussel‐Inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration	172
Rapid printing of bio-inspired 3D tissue constructs for skin regeneration	172
Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy	169
Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy	161
Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem	161
Activatable nanomedicine for overcoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumors	160
Injectable redox and light responsive MnO2 hybrid hydrogel for simultaneous melanoma therapy and multidrug-resistant bacteria-infected wound healing	159
NIR-II bioimaging of small organic molecule	156
Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice	150
Advances and perspectives in carrier-free nanodrugs for cancer chemo-monotherapy and combination therapy	150
Nanodrug with dual-sensitivity to tumor microenvironment for immuno-sonodynamic anti-cancer therapy	148

3D bioprinted neural tissue constructs for spinal cord injury repair	148
‘Green’ nanotherapeutics from tea leaves for orally targeted prevention and alleviation of colon diseases	139
A versatile nanocomposite based on nanoceria for antibacterial enhancement and protection from aPDT-aggravated inflammation via modulation of macrophage polarization	139
Bioinspired stratified electrowritten fiber-reinforced hydrogel constructs with layer-specific induction capacity for functional osteochondral regeneration	137
Emerging photodynamic nanotherapeutics for inducing immunogenic cell death and potentiating cancer immunotherapy	133
Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages	133
Infection microenvironment-related antibacterial nanotherapeutic strategies	130
Hyaluronic acid and chondroitin sulfate (meth)acrylate-based hydrogels for tissue engineering: Synthesis, characteristics and pre-clinical evaluation	128
Resolution of inflammation in bone regeneration: From understandings to therapeutic applications	128
Exosomes-loaded thermosensitive hydrogels for corneal epithelium and stroma regeneration	128
Optimized BMSC-derived osteoinductive exosomes immobilized in hierarchical scaffold via lyophilization for bone repair through Bmpr2/Acvr2b competitive receptor-activated Smad pathway	124
Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand	123
Intelligent MoS2–CuO heterostructures with multiplexed imaging and remarkably enhanced antitumor efficacy via synergetic photothermal therapy/ chemodynamic therapy/ immunotherapy	123
Functionalized 3D-printed silk-hydroxyapatite scaffolds for enhanced bone regeneration with innervation and vascularization	123
Infection microenvironment-activated nanoparticles for NIR-II photoacoustic imaging-guided photothermal/chemodynamic synergistic anti-infective therapy	121
Microenvironment-driven sequential ferroptosis, photodynamic therapy, and chemotherapy for targeted breast cancer therapy by a cancer-cell-membrane-coated nanoscale metal-organic framework	119
Cryogel/hydrogel biomaterials and acupuncture combined to promote diabetic skin wound healing through immunomodulation	118
Targeting nanoparticles for diagnosis and therapy of bone tumors: Opportunities and challenges	118
How microbes read the map: Effects of implant topography on bacterial adhesion and biofilm formation	117
NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens	113
Free radicals for cancer theranostics	113
Biomimetic glycopeptide hydrogel coated PCL/nHA scaffold for enhanced cranial bone regeneration via macrophage M2 polarization-induced osteo-immunomodulation	113
Polymeric nanoparticle vaccines to combat emerging and pandemic threats	110
Immunopolarization-regulated 3D printed-electrospun fibrous scaffolds for bone regeneration	106
High-quality milk exosomes as oral drug delivery system	106
Near-infrared-II activated inorganic photothermal nanomedicines	106
The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood–brain barrier and attenuates their targeting ability to brain tumor	106
Aligned microfiber-induced macrophage polarization to guide schwann-cell-enabled peripheral nerve regeneration	106
A micro/nano-biomimetic coating on titanium orchestrates osteo/angio-genesis and osteoimmunomodulation for advanced osseointegration	105
Chitosan hydrogel/3D-printed poly(ε‐caprolactone) hybrid scaffold containing synovial mesenchymal stem cells for cartilage regeneration based on tetrahedral framework nucleic acid recruitment	105
Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine	104
Advances in 3D bioprinting of tissues/organs for regenerative medicine and in-vitro models	103
Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm	102
MSC spheroids-loaded collagen hydrogels simultaneously promote neuronal differentiation and suppress inflammatory reaction through PI3K-Akt signaling pathway	102
Nanobiomaterial-based vaccination immunotherapy of cancer	101
Heparanase-driven sequential released nanoparticles for ferroptosis and tumor microenvironment modulations synergism in breast cancer therapy	101
Skin-inspired gelatin-based flexible bio-electronic hydrogel for wound healing promotion and motion sensing	101
Understanding the role of tissue-specific decellularized spinal cord matrix hydrogel for neural stem/progenitor cell microenvironment reconstruction and spinal cord injury	100
Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing	99
3D-printable plant protein-enriched scaffolds for cultivated meat development	98
Near-infrared light II - assisted rapid biofilm elimination platform for bone implants at mild temperature	98
3D-bioprinted BMSC-laden biomimetic multiphasic scaffolds for efficient repair of osteochondral defects in an osteoarthritic rat model	97
Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis	97
A tunable self-healing ionic hydrogel with microscopic homogeneous conductivity as a cardiac patch for myocardial infarction repair	97
AIEgens for microbial detection and antimicrobial therapy	95
Cancer-activated doxorubicin prodrug nanoparticles induce preferential immune response with minimal doxorubicin-related toxicity	95
3D cell-printing of biocompatible and functional meniscus constructs using meniscus‐derived bioink	95
Recent development of metal-organic framework nanocomposites for biomedical applications	95
Cell migration regulated by RGD nanospacing and enhanced under moderate cell adhesion on biomaterials	95
Small molecules combined with collagen hydrogel direct neurogenesis and migration of neural stem cells after spinal cord injury	95

Trends of microneedle technology in the scientific literature, patents, clinical trials and internet activity	94
Cancer cell membrane camouflaged iridium complexes functionalized black-titanium nanoparticles for hierarchical-targeted synergistic NIR-II photothermal and sonodynamic therapy	93
A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury	92
Virus-like nanoparticle as a co-delivery system to enhance efficacy of CRISPR/Cas9-based cancer immunotherapy	92
Tough magnesium phosphate-based 3D-printed implants induce bone regeneration in an equine defect model	92
Phenolic immunogenic cell death nanoinducer for sensitizing tumor to PD-1 checkpoint blockade immunotherapy	91
Noninvasively immunogenic sonodynamic therapy with manganese protoporphyrin liposomes against triple-negative breast cancer	91
Injectable immunomodulation-based porous chitosan microspheres/HPCH hydrogel composites as a controlled drug delivery system for osteochondral regeneration	90
Cationization to boost both type I and type II ROS generation for photodynamic therapy	90
Engineering oxygen-deficient ZrO2-x nanoplatform as therapy-activated “immunogenic cell death (ICD)” inducer to synergize photothermal-augmented sonodynamic tumor elimination in NIR-II biological wind	89
A redox-triggered C-centered free radicals nanogenerator for self-enhanced magnetic resonance imaging and chemodynamic therapy	89
Red-light-triggered self-destructive mesoporous silica nanoparticles for cascade-amplifying chemo-photodynamic therapy favoring antitumor immune responses	89
Nanoengineered shear-thinning and bioprintable hydrogel as a versatile platform for biomedical applications	89
Versatile hollow COF nanospheres via manipulating transferrin corona for precise glioma-targeted drug delivery	88
Tumor-derived exosomes co-delivering aggregation-induced emission luminogens and proton pump inhibitors for tumor glutamine starvation therapy and enhanced type-I photodynamic therapy	88
Covalent grafting of hyperbranched poly-L-lysine on Ti-based implants achieves dual functions of antibacteria and promoted osteointegration in vivo	88
Injectable hydrogels with high drug loading through B–N coordination and ROS-triggered drug release for efficient treatment of chronic periodontitis in diabetic rats	88