OOIR: Observatory of International Research

Papers

(The TQCC of Biotechnology Letters is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Influence of affinity tags and tobacco PR1a signal peptide on detection, purification and bioactivity analyses of the small oomycete apoplastic effectors	89
Anaerobic biofilm enriched with an ammonia tolerant methanogenic consortium to improve wastewater treatment in the fishing industry	38
Listeria monocytogenes is a solvent tolerant organism secreting a solvent stable lipase: potential biotechnological applications	37
Activation of galactose utilization by the addition of glucose for the fermentation of agar hydrolysate using Lactobacillus brevis ATCC 14869	36
Cell density detection based on a microfluidic chip with two electrode pairs	36
Synthesis of β-ionone from xylose and lignocellulosic hydrolysate in genetically engineered oleaginous yeast Yarrowia lipolytica	31
The pedal-like loop of (R)-selective transaminases plays a critical role to the functionality of the enzyme	29
Recombinant expression, downstream optimization, and therapeutic evaluation of recombinant human interleukin-37 for cancer therapy	29
Enhancement of riboflavin production in Bacillus subtilis via in vitro and in vivo metabolic engineering of pentose phosphate pathway	27
Unraveling the molecular mechanisms of selenite reduction: transcriptomic analysis of Bacillus reveals the key role of sulfur assimilation	27
Silica nanoparticles enhance interfacial self-adherence of a multi-layered extracellular matrix scaffold for vascular tissue regeneration	25
Directed evolution of cholesterol oxidase with improved thermostability using error-prone PCR	22
Squalene hopene cyclases and oxido squalene cyclases: potential targets for regulating cyclisation reactions	18
High throughput screening and metabolic engineering of Saccharopolyspora spinosa for spinosad production	17
Factors affecting rAAV titers during triple-plasmid transient transfection in HEK-293 cells	16
Efficient immobilization behavior and mechanism investigation of Pb(II) by Aspergillus tubingensis	16
Application of lactose based autoinduction for heterologous production of an active [NiFe] hydrogenase in E. coli	15
Synergistic anticancer effects of interleukin-21 combined with therapeutic peptides in multiple cancer cells	15
Application of exogenous melatonin in vitro and in planta: a review of its effects and mechanisms of action	15
Design and application of expression constructs for FMDV serotype O structural proteins	15
Paenibacillus barengoltzii: isolation, growth, and characterization of a high dextrinizer α-amylase	14
Biocontrol of strawberry Botrytis gray mold and prolong the fruit shelf-life by fumigant Trichoderma spp.	14
Retraction Note: Autophagy regulated by lncRNA HOTAIR contributes to the cisplatin-induced resistance in endometrial cancer cells	13
Identification of laccase genes in Trichoderma asperellum Ts93	13
BMSCs improve TNBS-induced colitis in rats by inducing Treg differentiation by expressing PD-L1	12

Clinical and mechanistic insights into biomedical application of Se-enriched probiotics and biogenic selenium nanoparticles	12
Therapeutic potential of a novel IP-10-(anti-HER2 scFv) fusion protein for the treatment of HER2-positive breast cancer	12
Retraction Note: TP53INP1 3′-UTR functions as a ceRNA in repressing the metastasis of glioma cells by regulating miRNA activity	12
Metabolic response of Bacillus spp. to heavy metal stress: pathway alterations and metabolite profiles	12
Isolation, microscopic and magnetotactic characterization of Magnetospirillum moscoviense MS-24 from Banjosa Lake, Pakistan	11
Enhancement hispolon production from Phellinus linteus via epigenetic-modified culture to inhibit human breast cancer cells	11
Optimizing hyaluronic acid production by Streptococcus zooepidemicus using taguchi method: effects of temperature and pH	11
Succession from acetoclastic to hydrogenotrophic microbial community during sewage sludge anaerobic digestion for bioenergy production	10
Research on the application of heterotrophic nitrification-aerobic denitrification bacteria in membrane bioreactor (MBR)	10
Gallic acid as biofilm inhibitor can improve transformation efficiency of Ruminiclostridium papyrosolvens	10
Magnetic particle-based chemiluminescence immunoassay for serum human heart-type fatty acid binding protein measurement	10
Substrate type and CO2 addition significantly influence succinic acid production of Basfia succiniciproducens	10
Calumenin knockdown, by intronic artificial microRNA, to improve expression efficiency of the recombinant human coagulation factor IX	10
Role of microbial pesticides in pest control for lepidopteran: research status and prospect	10
An artificial multienzyme cascade for the whole-cell synthesis of rare ketoses from glycerol	9
Cellulase and chitinase activities and antagonism against Fusarium oxysporum f.sp. cubense race 1 of six Trichoderma strains isolated from Mexican maize cropping	9
Characterization of a novel Escherichia coli recombineering selection/counterselection cassette	9
Micro-electrochemical DO sensor with ultra-micropore matrix fabricated with femtosecond laser processing successfully applied in on-line DO monitoring for yeast culture	9
Combining biotechnology with sustainability: feasibility of bioenergy sorghum in generating high-value bioproducts	9
Construction of a bacteriophage-derived vector with potential applications in targeted drug delivery and cell imaging	9
The modification of heme special importer to improve the production of active hemoglobins in Escherichia coli	9
Application of low-intensity ultrasound to enhance simultaneous nitrification/iron-based autotrophic denitrification	8
Transcriptome expression profiles reveal response mechanisms to drought and drought-stress mitigation mechanisms by exogenous glycine betaine in maize	8
Toxicants improve glycerol production in the fermentation of undetoxified hydrolysate by Candida glycerinogenes	8
Rapid and cost-effective screening of CRISPR/Cas9-induced mutants by DNA-guided Argonaute nuclease	8
Measurement of HbA1c with a new phase function using RBC phase image from a low-cost digital holographic microscopy	8
The variation of microorganisms and organics during methane production from lignite under an electric field	8
Exploration of a three-dimensional matrix as micro-reactor in the form of reactive polyaminosaccharide hydrogel beads using multipoint covalent interaction approach	8
Bone marrow mesenchymal stem cell-derived exosomes loaded with miR-26a through the novel immunomodulatory peptide DP7-C can promote osteogenesis	8
Improving the specific activity and stability of alkaline pectinase PEL3 through SpyTag/SpyCatcher cyclization	8
Enhancement of cordycepin production from Cordyceps militaris culture by epigenetic modification	7
A critical appraisal of humanized alternatives to fetal bovine serum for clinical applications of umbilical cord derived mesenchymal stromal cells	7
Trichoderma longibrachiatum and thermothelomyces thermophilus co-culture: improvement the saccharification profile of different sugarcane bagasse varieties	7
Application of CRISPR-Cas9 in microbial cell factories	7
Genome-scale metabolic model-based engineering of Escherichia coli enhances recombinant single-chain antibody fragment production	7
Biotransformation of C20- and C22-polyunsaturated fatty acids to 11S- and 13S-hydroxy fatty acids by Escherichia coli expressing 11S-lipoxygenase from Enhygromyxa salina	7
Mutational analysis of pig tissue factor pathway inhibitor α to increase anti-coagulation activity in pig-to-human xenotransplantation	7
Development of a synthetic transcription factor-based S-adenosylmethionine biosensor in Saccharomyces cerevisiae	7
Economic optimization of expression of soluble human epidermal growth factor in Escherichia coli	7
Investigation of osteogenesis and angiogenesis in perfusion bioreactors using improved multi-layer PCL-nHA-nZnO electrospun scaffolds	7
Preparation of white rot fungal inoculum and its application to bioremediation of chlorimuron-ethyl-contaminated soil	7
Differentiation, maturation, and collection of THP-1-derived dendritic cells based on a PEG hydrogel culture platform	7
Identification, molecular and biochemical characterization of a novel thermoactive and thermostable glucoamylase from Thermoanaerobacter ethanolicus	7
Aptamer-functionalized MOFs and AI-driven strategies for early cancer diagnosis and therapeutics	7
A novel P450 enzyme assay utilizing an NADP+-based biosensor	7
Dynamic cultivation of human mesenchymal stem/stromal cells for the production of extracellular vesicles in a 3D bioreactor system	7
Optimizing microbial electrolysis cell performance: strategies to mitigate electron mediator degradation on membranes	7
Improving the hydrophilic microenvironment surrounding the catalytic site of fructosyltransferase enhances its catalytic ability	7
Effects of the deletion and substitution of thioesterase on bacillomycin D synthesis	6
Pilot-scale production of Bacillus subtilis MSCL 897 spore biomass and antifungal secondary metabolites in a low-cost medium	6

Carrier immobilization and auto-exposition favoring reuse of silyletherase SilE-R from Brassica sp. with high activity and enantiospecificity	6
Isolation and characterisation of exosomes from Chinese hamster ovary (CHO) cells	6
Roles of PKAc1 and CRE1 in cellulose degradation, conidiation, and yellow pigment synthesis in Trichoderma reesei QM6a	6
A gold nanoparticles-based lateral flow assay utilizing baculovirus expressed recombinant nucleocapsid and receptor binding domain proteins for serodetection of IgG and IgM against SARS-CoV-2	6
Optimization of ultrasound-assisted production of ergosterol from Penicillium brevicompactum by Taguchi statistical method	6
Establishment of a visual gene knockout system based on CRISPR/Cas9 for the rare actinomycete Nonomuraea gerenzanensis	6
Homo- and heterofermentative lactobacilli are distinctly affected by furanic compounds	6
Molecular cloning and characterization of an alpha-amylase inhibitor (TkAAI) gene from Trichosanthes kirilowii Maxim.	6
Correction to: Multilineage differentiation of muscle-derived stem cells from GFP transgenic mice	6
Exploring potential bacterial populations for enhanced anthraquinone dyes biodegradation: a critical review	6
Antimicrobial activity of thermophilin 110 against the opportunistic pathogen Cutibacterium acnes	6
Current advances and future prospects in production of recombinant insulin and other proteins to treat diabetes mellitus	6
Engineering a synthesis-friendly serum responsive promoter for antibiotic selection of genomic integration in cell-based therapy	6
Advanced biotechnology using methyltransferase and its applications in bacteria: a mini review	6
A cell-free fluorescence biosensor based on allosteric transcription factor NalC for detection of pentachlorophenol	6
Enhanced soluble expression of active recombinant human interleukin-29 using champion pET SUMO system	6
Cost-effective production of squalene using Yarrowia lipolytica via metabolic engineering and fermentation engineering	6
Competitive inhibition of a non-natural cofactor dependent formaldehyde dehydrogenase by imidazole	6
Expansion of YALIcloneHR toolkit for Yarrowia lipolytica combined with Golden Gate and CRISPR technology	6
Efficient and high-density immobilization of animal cells by a microfiber with both swelling and cell adhesion properties and its application to exosome production	5
Development of an animal-derived component-free medium for Spodoptera frugiperda (Sf9) cells using response surface methodology	5
Recombinant protein CP01850 adjuvanted with Iridea cordata or Sacorpletis skottibergii lipid extracts protected mice against infection by Corynebacterium pseudotuberculosis	5
Retraction Note: Characterization of a new bacteriocin-like inhibitory peptide produced by Lactobacillus sakei B-RKM 0559	5
Improving pharmacological activities of thrombopoietin mimetic peptide by genetic fusion to albumin-binding domain	5
Statistical optimization of thermostable alkaline protease from Bacillus cereus KM 05 using response surface methodology	5
Regulation of fadR on the ROS defense mechanism in Shewanalla oneidensis	5
Antibiotic-free production of sucrose isomerase in Bacillus subtilis by genome integration	5
Monitoring of a microbial community during bioaugmentation with hydrogenotrophic methanogens to improve methane yield of an anaerobic digestion process	5
From yeast screening for suitability as single cell protein to fed-batch cultures	5
Citrus essential oil: would it be feasible as antimicrobial in the bioethanol industry?	5
Biogenesis and characterization of proficient silver nanoparticles employing marine procured fungi Hamigera pallida and assessment of their antioxidative, antimicrobial and anticancer potency	5
GH2 family β-galactosidases evolution using degenerate oligonucleotide gene shuffling	5
Redifferentiation of genetically modified dedifferentiated chondrocytes in a microcavitary hydrogel	5
Improvement of transglutaminase production by controlling the morphology of Streptomyces mobaraensis HVCP-Sm1 with microparticle-enhanced cultivation	5
Completely noninvasive multi-analyte monitoring system for cell culture processes	5
Assessment of population structure, genetic diversity and relationship of Mediterranean olive accessions using SSR markers and computational tools	5
Production enhancement of the glycopeptide antibiotic A40926 by an engineered Nonomuraea gerenzanensis strain	5
A novel thermophilic β-carotene 15,15′-monooxygenase with broad substrate specificity from the marine bacterium Candidatus Pelagibacter sp. HTCC7211	5
Recombinant AcMNPV-gp64-EGFP and synergist triphenyl phosphate, an effective combination against Spodoptera frugiperda	5
ANCUT1, a novel thermoalkaline cutinase from Aspergillus nidulans and its application on hydroxycinnamic acids lipophilization	5
Supplementation of articular cartilage-derived chondroprogenitors with bone morphogenic protein-9 enhances chondrogenesis without affecting hypertrophy	5
Anti-inflammatory potential of baicalein combined with silk fibroin protein in a zebrafish model (Danio rerio)	5
RETRACTED ARTICLE: Characterization of a new bacteriocin-like inhibitory peptide produced by Lactobacillus sakei B-RKM 0559	5
swnk plays an important role in the biosynthesis of swainsonine in Metarhizium anisopliae	5
Identification of antifungal metabolites from a soil-derived Streptomyces strain active against Fusarium graminearum using genome mining	5
De novo biosynthesis of 2′-fucosyllactose in engineered Pichia pastoris	5
Integrated bioinformatics based subtractive genomics approach to decipher the therapeutic function of hypothetical proteins from Salmonella typhi XDR H-58 strain	5
Enhanced activity of hyperthermostable Pyrococcus horikoshii endoglucanase in superbase ionic liquids	5
Synthesis of di-rhamnolipids by the avirulent, mono-rhamnolipid producing strain Pseudomonas aeruginosa ATCC 9027	5
Antigenic and conserved peptides from diverse Helicobacter pylori antigens	5
An inducible Komagataella phaffii system for protein expression using sorbitol dehydrogenase promoter	5
WAVE-based intensified perfusion cell culture for fast process development	5
CRISPR/Cas9-assisted ssDNA recombineering for site-directed mutagenesis and saturation mutagenesis of plasmid-encoded genes	5