OOIR: Observatory of International Research

Papers

(The TQCC of Biotechnology Letters is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
The pedal-like loop of (R)-selective transaminases plays a critical role to the functionality of the enzyme	77
Influence of affinity tags and tobacco PR1a signal peptide on detection, purification and bioactivity analyses of the small oomycete apoplastic effectors	34
Activation of galactose utilization by the addition of glucose for the fermentation of agar hydrolysate using Lactobacillus brevis ATCC 14869	29
Listeria monocytogenes is a solvent tolerant organism secreting a solvent stable lipase: potential biotechnological applications	29
Cell density detection based on a microfluidic chip with two electrode pairs	29
Silica nanoparticles enhance interfacial self-adherence of a multi-layered extracellular matrix scaffold for vascular tissue regeneration	27
Enhancement of riboflavin production in Bacillus subtilis via in vitro and in vivo metabolic engineering of pentose phosphate pathway	27
Synthesis of β-ionone from xylose and lignocellulosic hydrolysate in genetically engineered oleaginous yeast Yarrowia lipolytica	26
Recombinant expression, downstream optimization, and therapeutic evaluation of recombinant human interleukin-37 for cancer therapy	24
Uncoupling glucose sensing from GAL metabolism for heterologous lactose fermentation in Saccharomyces cerevisiae	23
Design of fusion protein for efficient preparation of cyanovirin-n and rapid enrichment of pseudorabies virus	23
Unraveling the molecular mechanisms of selenite reduction: transcriptomic analysis of Bacillus reveals the key role of sulfur assimilation	22
Directed evolution of cholesterol oxidase with improved thermostability using error-prone PCR	22
Anaerobic biofilm enriched with an ammonia tolerant methanogenic consortium to improve wastewater treatment in the fishing industry	20
Design and application of expression constructs for FMDV serotype O structural proteins	17
Squalene hopene cyclases and oxido squalene cyclases: potential targets for regulating cyclisation reactions	16
Efficient immobilization behavior and mechanism investigation of Pb(II) by Aspergillus tubingensis	15
Retraction Note: Autophagy regulated by lncRNA HOTAIR contributes to the cisplatin-induced resistance in endometrial cancer cells	15
Factors affecting rAAV titers during triple-plasmid transient transfection in HEK-293 cells	15
Synergistic anticancer effects of interleukin-21 combined with therapeutic peptides in multiple cancer cells	15
Application of exogenous melatonin in vitro and in planta: a review of its effects and mechanisms of action	15
Identification of laccase genes in Trichoderma asperellum Ts93	15
Production of flavonol and flavone 6-C-glucosides by bioconversion in Escherichia coli expressing a C-glucosyltransferase from wasabi (Eutrema japonicum)	14
Clinical and mechanistic insights into biomedical application of Se-enriched probiotics and biogenic selenium nanoparticles	14
Mutant firefly luciferase enzymes resistant to the inhibition by sodium chloride	14

Biocontrol of strawberry Botrytis gray mold and prolong the fruit shelf-life by fumigant Trichoderma spp.	14
Isolation, microscopic and magnetotactic characterization of Magnetospirillum moscoviense MS-24 from Banjosa Lake, Pakistan	12
Succession from acetoclastic to hydrogenotrophic microbial community during sewage sludge anaerobic digestion for bioenergy production	12
Retraction Note: TP53INP1 3′-UTR functions as a ceRNA in repressing the metastasis of glioma cells by regulating miRNA activity	12
Serum-derived exosomes accelerate scald wound healing in mice by optimizing cellular functions and promoting Akt phosphorylation	12
Calumenin knockdown, by intronic artificial microRNA, to improve expression efficiency of the recombinant human coagulation factor IX	11
Enhancement hispolon production from Phellinus linteus via epigenetic-modified culture to inhibit human breast cancer cells	11
Therapeutic potential of a novel IP-10-(anti-HER2 scFv) fusion protein for the treatment of HER2-positive breast cancer	11
Efficient production of l-menthyl α-glucopyranoside from l-menthol via whole-cell biotransformation using recombinant Escherichia coli	11
BMSCs improve TNBS-induced colitis in rats by inducing Treg differentiation by expressing PD-L1	11
Valorization of sugar beet pulp through biotechnological approaches: recent developments	10
Magnetic particle-based chemiluminescence immunoassay for serum human heart-type fatty acid binding protein measurement	10
The modification of heme special importer to improve the production of active hemoglobins in Escherichia coli	10
Substrate type and CO2 addition significantly influence succinic acid production of Basfia succiniciproducens	10
Research on the application of heterotrophic nitrification-aerobic denitrification bacteria in membrane bioreactor (MBR)	10
Gallic acid as biofilm inhibitor can improve transformation efficiency of Ruminiclostridium papyrosolvens	10
Cellulase and chitinase activities and antagonism against Fusarium oxysporum f.sp. cubense race 1 of six Trichoderma strains isolated from Mexican maize cropping	10
Application of low-intensity ultrasound to enhance simultaneous nitrification/iron-based autotrophic denitrification	9
Development of a synthetic transcription factor-based S-adenosylmethionine biosensor in Saccharomyces cerevisiae	9
Exploration of a three-dimensional matrix as micro-reactor in the form of reactive polyaminosaccharide hydrogel beads using multipoint covalent interaction approach	9
Micro-electrochemical DO sensor with ultra-micropore matrix fabricated with femtosecond laser processing successfully applied in on-line DO monitoring for yeast culture	9
Rapid and cost-effective screening of CRISPR/Cas9-induced mutants by DNA-guided Argonaute nuclease	9
Laboratory scale cultivation of Salinispora tropica in shake flasks and mechanically stirred bioreactors	9
An artificial multienzyme cascade for the whole-cell synthesis of rare ketoses from glycerol	8
The variation of microorganisms and organics during methane production from lignite under an electric field	8
Improving the specific activity and stability of alkaline pectinase PEL3 through SpyTag/SpyCatcher cyclization	8
Aptamer-functionalized MOFs and AI-driven strategies for early cancer diagnosis and therapeutics	8
Application of CRISPR-Cas9 in microbial cell factories	8
Transcriptome expression profiles reveal response mechanisms to drought and drought-stress mitigation mechanisms by exogenous glycine betaine in maize	8
High-cell-density fed-batch cultivations of Vibrio natriegens	8
Characterization of a novel Escherichia coli recombineering selection/counterselection cassette	8
Bone marrow mesenchymal stem cell-derived exosomes loaded with miR-26a through the novel immunomodulatory peptide DP7-C can promote osteogenesis	8
Construction of a bacteriophage-derived vector with potential applications in targeted drug delivery and cell imaging	7
Genome-scale metabolic model-based engineering of Escherichia coli enhances recombinant single-chain antibody fragment production	7
Simple stain-free screening method for pectinolytic microorganisms under alkalophilic conditions	7
Investigation of osteogenesis and angiogenesis in perfusion bioreactors using improved multi-layer PCL-nHA-nZnO electrospun scaffolds	7
Differentiation, maturation, and collection of THP-1-derived dendritic cells based on a PEG hydrogel culture platform	7
Trichoderma longibrachiatum and thermothelomyces thermophilus co-culture: improvement the saccharification profile of different sugarcane bagasse varieties	7
Toxicants improve glycerol production in the fermentation of undetoxified hydrolysate by Candida glycerinogenes	7
Economic optimization of expression of soluble human epidermal growth factor in Escherichia coli	7
Enhancement of cordycepin production from Cordyceps militaris culture by epigenetic modification	7
Identification, molecular and biochemical characterization of a novel thermoactive and thermostable glucoamylase from Thermoanaerobacter ethanolicus	6
Preparation of white rot fungal inoculum and its application to bioremediation of chlorimuron-ethyl-contaminated soil	6
Engineering a synthesis-friendly serum responsive promoter for antibiotic selection of genomic integration in cell-based therapy	6
Competitive inhibition of a non-natural cofactor dependent formaldehyde dehydrogenase by imidazole	6
Food-grade γ-aminobutyric acid production by immobilized glutamate decarboxylase from Lactobacillus plantarum in rice vinegar and monosodium glutamate system	6
Advanced biotechnology using methyltransferase and its applications in bacteria: a mini review	6
Homo- and heterofermentative lactobacilli are distinctly affected by furanic compounds	6
Biotransformation of C20- and C22-polyunsaturated fatty acids to 11S- and 13S-hydroxy fatty acids by Escherichia coli expressing 11S-lipoxygenase from Enhygromyxa salina	6
Dynamic cultivation of human mesenchymal stem/stromal cells for the production of extracellular vesicles in a 3D bioreactor system	6

Mutational analysis of pig tissue factor pathway inhibitor α to increase anti-coagulation activity in pig-to-human xenotransplantation	6
A critical appraisal of humanized alternatives to fetal bovine serum for clinical applications of umbilical cord derived mesenchymal stromal cells	6
A gold nanoparticles-based lateral flow assay utilizing baculovirus expressed recombinant nucleocapsid and receptor binding domain proteins for serodetection of IgG and IgM against SARS-CoV-2	6
Antimicrobial activity of thermophilin 110 against the opportunistic pathogen Cutibacterium acnes	6
Molecular cloning and characterization of an alpha-amylase inhibitor (TkAAI) gene from Trichosanthes kirilowii Maxim.	6
A cell-free fluorescence biosensor based on allosteric transcription factor NalC for detection of pentachlorophenol	6
Optimizing microbial electrolysis cell performance: strategies to mitigate electron mediator degradation on membranes	6
Improving the hydrophilic microenvironment surrounding the catalytic site of fructosyltransferase enhances its catalytic ability	6
Effects of the deletion and substitution of thioesterase on bacillomycin D synthesis	6
Pilot-scale production of Bacillus subtilis MSCL 897 spore biomass and antifungal secondary metabolites in a low-cost medium	6
Establishment of a visual gene knockout system based on CRISPR/Cas9 for the rare actinomycete Nonomuraea gerenzanensis	6
Isolation and characterisation of exosomes from Chinese hamster ovary (CHO) cells	6
Current advances and future prospects in production of recombinant insulin and other proteins to treat diabetes mellitus	6
Expansion of YALIcloneHR toolkit for Yarrowia lipolytica combined with Golden Gate and CRISPR technology	6
Optimization of ultrasound-assisted production of ergosterol from Penicillium brevicompactum by Taguchi statistical method	6
From yeast screening for suitability as single cell protein to fed-batch cultures	5
Statistical optimization of thermostable alkaline protease from Bacillus cereus KM 05 using response surface methodology	5
Regulation of fadR on the ROS defense mechanism in Shewanalla oneidensis	5
Synthesis of di-rhamnolipids by the avirulent, mono-rhamnolipid producing strain Pseudomonas aeruginosa ATCC 9027	5
Antigenic and conserved peptides from diverse Helicobacter pylori antigens	5
swnk plays an important role in the biosynthesis of swainsonine in Metarhizium anisopliae	5
Retraction Note: Characterization of a new bacteriocin-like inhibitory peptide produced by Lactobacillus sakei B-RKM 0559	5
ANCUT1, a novel thermoalkaline cutinase from Aspergillus nidulans and its application on hydroxycinnamic acids lipophilization	5
Biogenesis and characterization of proficient silver nanoparticles employing marine procured fungi Hamigera pallida and assessment of their antioxidative, antimicrobial and anticancer potency	5
Exploring potential bacterial populations for enhanced anthraquinone dyes biodegradation: a critical review	5
Anti-inflammatory potential of baicalein combined with silk fibroin protein in a zebrafish model (Danio rerio)	5
Supplementation of articular cartilage-derived chondroprogenitors with bone morphogenic protein-9 enhances chondrogenesis without affecting hypertrophy	5
A novel thermophilic β-carotene 15,15′-monooxygenase with broad substrate specificity from the marine bacterium Candidatus Pelagibacter sp. HTCC7211	5
Enhanced activity of hyperthermostable Pyrococcus horikoshii endoglucanase in superbase ionic liquids	5
Completely noninvasive multi-analyte monitoring system for cell culture processes	5
Application of three-dimensional cell culture technology in screening anticancer drugs	5
Improving pharmacological activities of thrombopoietin mimetic peptide by genetic fusion to albumin-binding domain	5
RETRACTED ARTICLE: Characterization of a new bacteriocin-like inhibitory peptide produced by Lactobacillus sakei B-RKM 0559	5
Antibiotic-free production of sucrose isomerase in Bacillus subtilis by genome integration	5
GH2 family β-galactosidases evolution using degenerate oligonucleotide gene shuffling	5
Citrus essential oil: would it be feasible as antimicrobial in the bioethanol industry?	5
Efficient and high-density immobilization of animal cells by a microfiber with both swelling and cell adhesion properties and its application to exosome production	5
CRISPR/Cas9-assisted ssDNA recombineering for site-directed mutagenesis and saturation mutagenesis of plasmid-encoded genes	5
Roles of PKAc1 and CRE1 in cellulose degradation, conidiation, and yellow pigment synthesis in Trichoderma reesei QM6a	5
Redifferentiation of genetically modified dedifferentiated chondrocytes in a microcavitary hydrogel	5
Production enhancement of the glycopeptide antibiotic A40926 by an engineered Nonomuraea gerenzanensis strain	5
An inducible Komagataella phaffii system for protein expression using sorbitol dehydrogenase promoter	5
WAVE-based intensified perfusion cell culture for fast process development	5
Recombinant AcMNPV-gp64-EGFP and synergist triphenyl phosphate, an effective combination against Spodoptera frugiperda	5
Development of an animal-derived component-free medium for Spodoptera frugiperda (Sf9) cells using response surface methodology	5
Switching the secondary and natural activity of Nitrilase from Acidovorax facilis 72 W for the efficient production of 2-picolinamide	5
Monitoring of a microbial community during bioaugmentation with hydrogenotrophic methanogens to improve methane yield of an anaerobic digestion process	5
Enhanced soluble expression of active recombinant human interleukin-29 using champion pET SUMO system	5
Correction to: Multilineage differentiation of muscle-derived stem cells from GFP transgenic mice	5