OOIR: Observatory of International Research

Papers

(The TQCC of Immunological Reviews is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance	279
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	238
Issue Information	147
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	100
Metabolic regulation of type I interferon production	95
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	88
Immune checkpoint inhibitors in infectious disease	88
Superoxide: The enigmatic chemical chameleon in neutrophil biology	86
The Structural Biology of T‐Cell Antigen Detection at Close Contacts	80
Imaging dendritic cell functions*	79
Cover Image	75
Antigen‐specific and cross‐reactive T cells in protection and disease	73
NETosis: Sculpting tumor metastasis and immunotherapy	71
Role of inflammasomes and neuroinflammation in epilepsy	67
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease	67
Issue Information	66
Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights	65
The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	65
Allosteric Changes Underlie the Outside‐In Transmission of Activatory Signals in the TCR	64
Thymic and extrathymic Aire‐expressing cells in maternal‐fetal tolerance*	61
The immune system in Down Syndrome: Autoimmunity and severe infections	58
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	57
Layered origins of lymphoid tissue inducer cells	56
The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals	54
B‐1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease	52

With complements: C3 inhibition in the clinic	49
Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria	48
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	48
Mechanisms Promoting Stability of B Cells	47
Maternal influences on offspring food allergy	45
Autoimmunity and the microbiome	45
Functional Insights From Immunoreceptor Structures	43
Issue Information	43
Cover Image	43
	42
Common variable immunodeficiency, cross currents, and prevailing winds	42
	42
Cortical Thymic Epithelial Cells: Key Developers of the Code of T‐Cell Selection and TCR Repertoire Diversity	41
Activation pathways that drive CD4⁺ T cells to break tolerance in autoimmune diseases*	39
Issue Information	39
ZAP70, too little, too much can lead to autoimmunity*	39
Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation	39
An introduction to neuroimmunology	38
Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*	38
T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma	38
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy	37
Issue Information	37
JAK/STAT defects and immune dysregulation, and guiding therapeutic choices	37
Deconstructing the Thymic Microenvironment Through Genesis to Senescence	37
Correction to “The Journey Toward Disease Modification in Cow Milk Protein Allergy”	37
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy	36
Axes of heterogeneity in human tissue‐resident memory T cells	36
Glycobiology of IgE	36
Targeting Bottlenecks in Malaria Transmission: Antibody‐Epitope Descriptions Guide the Design of Next‐Generation Biomedical Interventions	35
Fc‐FcγR interactions during infections: From neutralizing antibodies to antibody‐dependent enhancement	35
Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity	34
Modulation of immunity by the secreted phospholipase A₂ family	34
Human neutrophils ≠ murine neutrophils: Does it matter?	34
Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm*	33
	33
MAP Kinase Signaling at the Crossroads of Inflammasome Activation	33
Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma	33
PANoptosis: Mechanisms, biology, and role in disease	33
Cover Image	33
Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy*	32
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond	31
Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammation	31
Factor D	30
From Lymphotoxin to Tertiary Lymphoid Structures and Beyond	30
Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease	29
Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis	29
Host immune responses in the central nervous system during fungal infections	29
Development and organization of omental milky spots	29
Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system	29
Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease	29

Cell type‐specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases	29
Structural Immunology of SARS‐CoV‐2	29
Understanding inhibitory receptor function in neutrophils through the lens of CLEC12A	29
Irritable bowel syndrome: When food is a pain in the gut	29
Issue Information	28
	28
Many Achilles’ heels of B and T cell tolerance	28
Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic health	28
Cover Image	27
No time to die: Epigenetic regulation of natural killer cell survival	26
Human Atypical B Cells. An Overview	26
Cover Image	26
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	26
Innate Immunity and Asthma Exacerbations: Insights From Human Models	25
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	25
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	25
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	25
Transcriptional and epigenetic regulation in thymic epithelial cells*	25
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	24
Neutrophils in aging and aging‐related pathologies	23
Stability and change in epigenetic regulation of immune cells	23
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	23
Low‐molecular weight inhibitors of the alternative complement pathway	23
Issue Information	22
The impact of the human gut microbiome on the treatment of autoimmune disease	22
Issue Information	22
	22
Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	22
The nervous system during COVID‐19: Caught in the crossfire	21
Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	21
Visualization and functional characterization of lymphoid organ fibroblasts*	21
The impact of neuroinflammation on neuronal integrity	21
Epigenetic regulation of inflammation by CxxC domain‐containing proteins*	21
Innate Immune Receptors as Dynamic Modulators of Extrafollicular Autoimmune B Cell Response	20
ILC2 Diversity, Location, and Function in Pulmonary Disease	20
	20
Issue Information	20
	20
Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo	19
Thymflammation: The Role of a Constitutively Active Inflammatory Network and “Ectopic” Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond	19
Innate Immune Sensors in Health and Disease	19
Real‐time imaging of inflammation and its resolution: It’s apparent because it’s transparent*	19
Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: Current understanding and future directions	19
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death	19
Signals that control MAIT cell function in healthy and inflamed human tissues	19
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	18
Microbes and the fate of neutrophils	18
Life‐threatening antibodies: The discovery of anaphylaxis	18
Correction to “The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids”	18
The evolving landscape of immune‐related adverse events that follow immune checkpoint immunotherapy in cancer patients	18
	18
Imaging the immune system redux	18
Established and emerging roles for mitochondria in neutrophils	18
	18
Chemo‐ and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen*	18
Regulation of immune responses to food by commensal microbes	17
Role of B cells in immune‐related adverse events following checkpoint blockade	17
HLA‐E: Immune Receptor Functional Mechanisms Revealed by Structural Studies	17
Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches	17
IgE versus IgG and IgA: Differential roles of allergen‐specific antibodies in sensitization, tolerization, and treatment of allergies	17
Additional Cover	17