OOIR: Observatory of International Research

Papers

(The TQCC of Immunological Reviews is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Genetics in the Host‐Mycobacterium ulcerans interaction	205
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	191
Issue Information	139
Established and Emerging Roles of DEAD/H‐Box Helicases in Regulating Infection and Immunity	134
Regulation of the NLRP3 inflammasome by autophagy and mitophagy	131
Role of inflammasomes and neuroinflammation in epilepsy	116
The fibroblast: An emerging key player in thymic T cell selection	98
Neutrophils in aging and aging‐related pathologies	96
N1 versus N2 and PMN‐MDSC: A critical appraisal of current concepts on tumor‐associated neutrophils and new directions for human oncology	90
Low‐molecular weight inhibitors of the alternative complement pathway	68
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	62
B cells going viral in theCNS: Dynamics, complexities, and functions of B cells responding to viral encephalitis	59
Age‐related macular degeneration: A disease of extracellular complement amplification	56
Issue Information	53
Issue Information	49
	45
Regulation of CD8 T‐cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid	42
Cover Image	42
Current knowledge on the early stages of human neutropoiesis	41
Immunogenic cell death (ICD) enhancers—Drugs that enhance the perception of ICD by dendritic cells	41
Issue Information	41
Moving beyond velocity: Opportunities and challenges to quantify immune cell behavior*	40
Metabolic regulation of type I interferon production	36
Ontogeny and heterogeneity of innate lymphoid cells and the noncoding genome	36
The right educational environment: Oral tolerance in early life	36

Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells	36
Issue Information	34
Insights into the clinical, immunologic, and genetic underpinnings of food allergy	33
Cover Image	33
Pathogenic mechanisms in the evolution of food allergy	33
Sensory sentinels: Neuroimmune detection and food allergy	33
Issue Information	33
Many Achilles’ heels of B and T cell tolerance	32
Cover Image	32
At the crux of maternal immune activation: Viruses, microglia, microbes, and IL‐17A	32
Cover Image	31
Role of inhibitory B cell co‐receptors in B cell self‐tolerance to non‐protein antigens*	31
No time to die: Epigenetic regulation of natural killer cell survival	31
RNA regulatory mechanisms that control antiviral innate immunity	31
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	30
Layered immunity and layered leukemogenicity: Developmentally restricted mechanisms of pediatric leukemia initiation	30
The discovery of NLRP3 and its function in cryopyrin‐associated periodic syndromes and innate immunity	30
The resolution of phagosomes	29
Memories that last: Dynamics of memory T cells throughout the body	28
Role of inhibitory signaling in peripheral B cell tolerance*	28
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	28
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	27
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	27
Transcriptional and epigenetic regulation in thymic epithelial cells*	26
The potency of hematopoietic stem cell reprogramming for changing immune tone	26
In search of lost time: Enhancers as modulators of timing in lymphocyte development and differentiation	26
Functional genomics in inborn errors of immunity	26
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	25
Issue Information	24
Immunoglobulin A Antibodies: From Protection to Harmful Roles	24
The Effector Functions of Antibodies	24
Human fetal T cells: Insights into developmental specialization and mechanisms of lineage transition	23
The function of antibodies	23
Immune checkpoint inhibitors in infectious disease	23
A variety of death modes of neutrophils and their role in the etiology of autoimmune diseases	23
Enhancing Fc‐mediated effector functions of monoclonal antibodies: The example of HexaBodies	23
Chromodomain helicase DNA‐binding 4 (CHD4) regulates early B cell identity and V(D)J recombination*	22
Epigenetics and CD8⁺ T cell memory*	22
	22
Coengineering specificity, safety, and function into T cells for cancer immunotherapy	22
The neutrophil: A key resourceful agent in immune‐mediated vasculitis	22
Stability and change in epigenetic regulation of immune cells	21
Antigen‐specific and cross‐reactive T cells in protection and disease	21
Genetic variability shapes the alternative pathway complement activity and predisposition to complement‐related diseases	21
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	20
Superoxide: The enigmatic chemical chameleon in neutrophil biology	20
Rheumatic complications of checkpoint inhibitors: Lessons from autoimmunity	20
Cell‐intrinsic and ‐extrinsic roles of miRNAs in regulating T cell immunity	20
Amplifying “eat me signal” by immunogenic cell death for potentiating cancer immunotherapy	20
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	19

Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	19
Imaging the different timescales of germinal center selection*	19
Next‐generation chimeric antigen receptors for T‐ and natural killer‐cell therapies against cancer	19
NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance*	19
NETosis: Sculpting tumor metastasis and immunotherapy	19
Imaging dendritic cell functions*	19
	19
LAG Time in the Era of Immunotherapy—New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene‐3	18
Nucleic acid sensing in the central nervous system: Implications for neural circuit development, function, and degeneration	18
The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids	18
Issue Information	18
Plasma cell biology: Foundations for targeted therapeutic development in transplantation	17
	17
The immune system in Down Syndrome: Autoimmunity and severe infections	17
The cell stress and immunity cycle in cancer: Toward next generation of cancer immunotherapy	17
Issue Information	16
Regulatory strategies limiting endosomal Toll‐like receptor activation in B cells*	16
Inside the phagosome: A bacterial perspective	16
T‐cell heterogeneity, progenitor–progeny relationships, and function during latent and chronic viral infections	16
The gene regulatory network controlling plasma cell function	16
The nervous system during COVID‐19: Caught in the crossfire	16
Extrinsic and intrinsic drivers of natural killer cell clonality	16
Issue Information	15
Epigenetic gene regulation in plasma cells	15
Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	15
Runx proteins and transcriptional mechanisms that govern memory CD8 T cell development	15
Toward the clinical development of synthetic immunity to cancer	15
Routine SARS‐CoV‐2 vaccination for all children*	15
Neuroinflammation: Extinguishing a blaze of T cells	15
Issue Information	15
	15
Local complement synthesis—A process with near and far consequences for ischemia reperfusion injury and transplantation	15
Epigenetic regulation of inflammation by CxxC domain‐containing proteins*	15
Transforming mutations in the development of pathogenic B cell clones and autoantibodies*	15
	15
Cover Image	14
Visualization and functional characterization of lymphoid organ fibroblasts*	14
Eras of designer Tregs: Harnessing synthetic biology for immune suppression	14
Issue Information	14
Neutrophils as immune effector cells in antibody therapy in cancer	14
Z‐Nucleic Acid Sensing and Activation of ZBP1 in Cellular Physiology and Disease Pathogenesis	14
Thymic and extrathymic Aire‐expressing cells in maternal‐fetal tolerance*	14
The role of efferocytosis‐fueled macrophage metabolism in the resolution of inflammation	14
Lipid metabolism in dendritic cell biology	14
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	14
Allosteric Changes Underlie the Outside‐In Transmission of Activatory Signals in the TCR	13
Issue Information	13
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	13
	13
Epigenetics and tissue immunity—Translating environmental cues into functional adaptations*	13
	13
Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria	13
The Evolving T Cell Receptor Recognition Code: The Rules Are More Like Guidelines	13
Circulating tissue factor‐positive extracellular vesicles and their association with thrombosis in different diseases	13
Macrophage‐fibroblast circuits in the spleen	12
Modulation of plasmacytoid dendritic cells response in inflammation and autoimmunity	12
Interferons and epigenetic mechanisms in training, priming and tolerance of monocytes and hematopoietic progenitors	12
Neutrophil‐T cell crosstalk and the control of the host inflammatory response	12
The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	12
The role of donor‐unrestricted T‐cells, innate lymphoid cells, and NK cells in anti‐mycobacterial immunity	12
Cancer immunity by tissue‐resident type 1 innate lymphoid cells and killer innate‐like T cells	12
With complements: C3 inhibition in the clinic	12
Fibroblasts and macrophages: Collaborators in tissue homeostasis	12
Neutrophil modulation of behavior and cognition in health and disease: The unexplored role of an innate immune cell	12
The complement alternative pathway and hemostasis	12
ITAM‐based receptors in natural killer cells	12