OOIR: Observatory of International Research

Papers

(The TQCC of Immunological Reviews is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Issue Information	240
Cover Image	213
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease	162
Issue Information	149
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	148
Immune checkpoint inhibitors in infectious disease	132
The Structural Biology of T‐Cell Antigen Detection at Close Contacts	130
Role of inflammasomes and neuroinflammation in epilepsy	116
Antigen‐specific and cross‐reactive T cells in protection and disease	83
Imaging dendritic cell functions*	80
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	76
Cell‐intrinsic and ‐extrinsic roles of miRNAs in regulating T cell immunity	71
Superoxide: The enigmatic chemical chameleon in neutrophil biology	68
NETosis: Sculpting tumor metastasis and immunotherapy	63
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	60
Metabolic regulation of type I interferon production	59
Issue Information	58
The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	53
Thymic and extrathymic Aire‐expressing cells in maternal‐fetal tolerance*	51
Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria	49
Allosteric Changes Underlie the Outside‐In Transmission of Activatory Signals in the TCR	49
Layered origins of lymphoid tissue inducer cells	48
Fibroblasts and macrophages: Collaborators in tissue homeostasis	47
With complements: C3 inhibition in the clinic	47
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	47

Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights	46
B‐1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease	46
The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals	45
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	45
Cover Image	45
The immune system in Down Syndrome: Autoimmunity and severe infections	45
Autoimmunity and the microbiome	44
	44
Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*	40
An introduction to neuroimmunology	40
Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation	40
Common variable immunodeficiency, cross currents, and prevailing winds	40
T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma	39
Sequence determinants as key regulators in gene expression of T cells	39
Diving into the mechanism of action of tumor immunotherapies with intravital imaging*	38
Issue Information	37
ZAP70, too little, too much can lead to autoimmunity*	36
Activation pathways that drive CD4⁺ T cells to break tolerance in autoimmune diseases*	35
Maternal influences on offspring food allergy	35
Issue Information	35
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy	34
	34
Fc‐FcγR interactions during infections: From neutralizing antibodies to antibody‐dependent enhancement	32
Correction to “The Journey Toward Disease Modification in Cow Milk Protein Allergy”	32
Issue Information	32
Axes of heterogeneity in human tissue‐resident memory T cells	32
JAK/STAT defects and immune dysregulation, and guiding therapeutic choices	32
Targeting Bottlenecks in Malaria Transmission: Antibody‐Epitope Descriptions Guide the Design of Next‐Generation Biomedical Interventions	32
Modulation of immunity by the secreted phospholipase A₂ family	31
PANoptosis: Mechanisms, biology, and role in disease	31
Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm*	31
Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity	31
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy	31
MAP Kinase Signaling at the Crossroads of Inflammasome Activation	31
	30
Human neutrophils ≠ murine neutrophils: Does it matter?	30
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond	30
Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease	29
Cover Image	29
Structural Immunology of SARS‐CoV‐2	27
Perivascular stromal cells: Directors of tissue immune niches	27
Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammation	27
Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma	27
Factor D	26
Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy*	26
Irritable bowel syndrome: When food is a pain in the gut	26
Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic health	25
Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease	25
Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system	25
	25

Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis	25
Development and organization of omental milky spots	25
Host immune responses in the central nervous system during fungal infections	25
Cell type‐specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases	24
Understanding inhibitory receptor function in neutrophils through the lens of CLEC12A	24
Stability and change in epigenetic regulation of immune cells	23
Cover Image	23
No time to die: Epigenetic regulation of natural killer cell survival	23
Cover Image	23
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	23
Transcriptional and epigenetic regulation in thymic epithelial cells*	23
Issue Information	23
Many Achilles’ heels of B and T cell tolerance	23
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	23
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	23
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	22
Innate Immunity and Asthma Exacerbations: Insights From Human Models	22
Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	22
The fibroblast: An emerging key player in thymic T cell selection	22
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	22
Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	21
Issue Information	21
Low‐molecular weight inhibitors of the alternative complement pathway	21
	21
Neutrophils in aging and aging‐related pathologies	21
Issue Information	21
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	21
Fibroblast heterogeneity and tertiary lymphoid tissues in the kidney	20
The nervous system during COVID‐19: Caught in the crossfire	20
The impact of the human gut microbiome on the treatment of autoimmune disease	19
Epigenetic regulation of inflammation by CxxC domain‐containing proteins*	19
The gene regulatory network controlling plasma cell function	19
The impact of neuroinflammation on neuronal integrity	19
Regnase‐1–related endoribonucleases in health and immunological diseases	19
Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: Current understanding and future directions	18
Visualization and functional characterization of lymphoid organ fibroblasts*	18
Imaging leukocyte migration through afferent lymphatics*	18
Epigenetic gene regulation in plasma cells	18
The evolving landscape of immune‐related adverse events that follow immune checkpoint immunotherapy in cancer patients	18
	18
Signals that control MAIT cell function in healthy and inflamed human tissues	17
	17
	17
Established and emerging roles for mitochondria in neutrophils	17
Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo	17
Real‐time imaging of inflammation and its resolution: It’s apparent because it’s transparent*	17
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	17
Imaging the immune system redux	17
Innate Immune Sensors in Health and Disease	17
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death	17
Microbes and the fate of neutrophils	17
Issue Information	17
Innate Immune Receptors as Dynamic Modulators of Extrafollicular Autoimmune B Cell Response	17
Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches	16
Regulation of murine B lymphopoiesis by stromal cells	16
Correction to “The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids”	16
Life‐threatening antibodies: The discovery of anaphylaxis	16
Chemo‐ and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen*	16