OOIR: Observatory of International Research

Papers

(The TQCC of Immunological Reviews is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Issue Information	248
Issue Information	220
Immune checkpoint inhibitors in infectious disease	168
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	130
Superoxide: The enigmatic chemical chameleon in neutrophil biology	117
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	87
Cell‐intrinsic and ‐extrinsic roles of miRNAs in regulating T cell immunity	76
Cover Image	72
Imaging dendritic cell functions*	66
NETosis: Sculpting tumor metastasis and immunotherapy	66
The Structural Biology of T‐Cell Antigen Detection at Close Contacts	62
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease	60
Metabolic regulation of type I interferon production	54
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	54
Antigen‐specific and cross‐reactive T cells in protection and disease	53
Role of inflammasomes and neuroinflammation in epilepsy	51
Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance	50
Issue Information	48
Allosteric Changes Underlie the Outside‐In Transmission of Activatory Signals in the TCR	47
Layered origins of lymphoid tissue inducer cells	47
Thymic and extrathymic Aire‐expressing cells in maternal‐fetal tolerance*	47
B‐1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease	47
Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights	47
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	47
The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	46

With complements: C3 inhibition in the clinic	46
Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria	44
Fibroblasts and macrophages: Collaborators in tissue homeostasis	42
The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals	41
The immune system in Down Syndrome: Autoimmunity and severe infections	40
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	40
An introduction to neuroimmunology	39
ZAP70, too little, too much can lead to autoimmunity*	39
	39
Common variable immunodeficiency, cross currents, and prevailing winds	38
Cover Image	38
Diving into the mechanism of action of tumor immunotherapies with intravital imaging*	36
Sequence determinants as key regulators in gene expression of T cells	36
Autoimmunity and the microbiome	35
Issue Information	34
Maternal influences on offspring food allergy	34
T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma	33
Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation	33
Issue Information	33
Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*	33
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy	33
	33
Activation pathways that drive CD4⁺ T cells to break tolerance in autoimmune diseases*	33
Fc‐FcγR interactions during infections: From neutralizing antibodies to antibody‐dependent enhancement	32
Issue Information	32
Correction to “The Journey Toward Disease Modification in Cow Milk Protein Allergy”	32
Axes of heterogeneity in human tissue‐resident memory T cells	31
Targeting Bottlenecks in Malaria Transmission: Antibody‐Epitope Descriptions Guide the Design of Next‐Generation Biomedical Interventions	31
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy	31
JAK/STAT defects and immune dysregulation, and guiding therapeutic choices	30
Glycobiology of IgE	30
Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm*	30
Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity	30
MAP Kinase Signaling at the Crossroads of Inflammasome Activation	28
Human neutrophils ≠ murine neutrophils: Does it matter?	28
Modulation of immunity by the secreted phospholipase A₂ family	28
PANoptosis: Mechanisms, biology, and role in disease	27
Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease	27
	27
Structural Immunology of SARS‐CoV‐2	26
Cover Image	26
Factor D	26
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond	26
Perivascular stromal cells: Directors of tissue immune niches	25
Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease	25
Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammation	25
Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma	25
Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy*	25
Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic health	24
Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system	24

Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis	24
Cell type‐specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases	24
Development and organization of omental milky spots	24
	24
Host immune responses in the central nervous system during fungal infections	23
Issue Information	23
Irritable bowel syndrome: When food is a pain in the gut	23
Many Achilles’ heels of B and T cell tolerance	23
Understanding inhibitory receptor function in neutrophils through the lens of CLEC12A	23
Stability and change in epigenetic regulation of immune cells	23
Cover Image	22
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	22
The fibroblast: An emerging key player in thymic T cell selection	22
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	22
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	22
Innate Immunity and Asthma Exacerbations: Insights From Human Models	22
Cover Image	21
Transcriptional and epigenetic regulation in thymic epithelial cells*	21
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	21
No time to die: Epigenetic regulation of natural killer cell survival	21
Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	21
Low‐molecular weight inhibitors of the alternative complement pathway	20
Issue Information	20
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	20
Neutrophils in aging and aging‐related pathologies	20
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	20
Issue Information	20
Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	19
The nervous system during COVID‐19: Caught in the crossfire	19
Visualization and functional characterization of lymphoid organ fibroblasts*	19
	19
The gene regulatory network controlling plasma cell function	19
The impact of the human gut microbiome on the treatment of autoimmune disease	19
The evolving landscape of immune‐related adverse events that follow immune checkpoint immunotherapy in cancer patients	18
Signals that control MAIT cell function in healthy and inflamed human tissues	18
Regnase‐1–related endoribonucleases in health and immunological diseases	18
Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: Current understanding and future directions	18
Innate Immune Sensors in Health and Disease	18
	18
The impact of neuroinflammation on neuronal integrity	18
	18
Epigenetic regulation of inflammation by CxxC domain‐containing proteins*	18
Microbes and the fate of neutrophils	17
Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo	17
Real‐time imaging of inflammation and its resolution: It’s apparent because it’s transparent*	17
Innate Immune Receptors as Dynamic Modulators of Extrafollicular Autoimmune B Cell Response	17
Established and emerging roles for mitochondria in neutrophils	17
Imaging leukocyte migration through afferent lymphatics*	17
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	16
Issue Information	16
Thymflammation: The Role of a Constitutively Active Inflammatory Network and “Ectopic” Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond	16
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death	16
	16
Regulation of immune responses to food by commensal microbes	15
IgE versus IgG and IgA: Differential roles of allergen‐specific antibodies in sensitization, tolerization, and treatment of allergies	15
Imaging the immune system redux	15
Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches	15
Small matters: Introduction to extracellular vesicles	15
Life‐threatening antibodies: The discovery of anaphylaxis	15
Chemo‐ and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen*	15
Correction to “The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids”	15
Copper homeostasis and cuproptosis in cancer immunity and therapy	15
Immunoregulation by antibody secreting cells in inflammation, infection, and cancer	15
	15
Role of B cells in immune‐related adverse events following checkpoint blockade	15
HLA‐E: Immune Receptor Functional Mechanisms Revealed by Structural Studies	15
Introductory article for Immunological Reviews, Vol 310	15