Immunological Reviews

Article	Citations
Issue Information	265
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	232
Antigen‐specific and cross‐reactive T cells in protection and disease	183
Cover Image	118
Cell‐intrinsic and ‐extrinsic roles of miRNAs in regulating T cell immunity	93
The Structural Biology of T‐Cell Antigen Detection at Close Contacts	84
Role of inflammasomes and neuroinflammation in epilepsy	79
Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance	77
Immune checkpoint inhibitors in infectious disease	72
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	70
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease	69
Metabolic regulation of type I interferon production	69
NETosis: Sculpting tumor metastasis and immunotherapy	65
Imaging dendritic cell functions*	62
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	59
Superoxide: The enigmatic chemical chameleon in neutrophil biology	59
Issue Information	58
B‐1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease	58
The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals	58
Layered origins of lymphoid tissue inducer cells	57
With complements: C3 inhibition in the clinic	55
Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria	53
Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights	51
The immune system in Down Syndrome: Autoimmunity and severe infections	51
Thymic and extrathymic Aire‐expressing cells in maternal‐fetal tolerance*	50

The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	48
Allosteric Changes Underlie the Outside‐In Transmission of Activatory Signals in the TCR	44
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	43
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	43
An introduction to neuroimmunology	42
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Diving into the mechanism of action of tumor immunotherapies with intravital imaging*	40
Autoimmunity and the microbiome	39
Maternal influences on offspring food allergy	39
Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation	38
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy	38
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Sequence determinants as key regulators in gene expression of T cells	36
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T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma	35
Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*	35
Common variable immunodeficiency, cross currents, and prevailing winds	35
Activation pathways that drive CD4+ T cells to break tolerance in autoimmune diseases*	34
ZAP70, too little, too much can lead to autoimmunity*	34
Functional Insights From Immunoreceptor Structures	34
Cortical Thymic Epithelial Cells: Key Developers of the Code of T‐Cell Selection and TCR Repertoire Diversity	34
Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity	33
Deconstructing the Thymic Microenvironment Through Genesis to Senescence	33
Issue Information	33
Fc‐FcγR interactions during infections: From neutralizing antibodies to antibody‐dependent enhancement	33
Correction to “The Journey Toward Disease Modification in Cow Milk Protein Allergy”	32
Targeting Bottlenecks in Malaria Transmission: Antibody‐Epitope Descriptions Guide the Design of Next‐Generation Biomedical Interventions	32
Glycobiology of IgE	32
JAK/STAT defects and immune dysregulation, and guiding therapeutic choices	31
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy	31
Human neutrophils ≠ murine neutrophils: Does it matter?	31
Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm*	31
MAP Kinase Signaling at the Crossroads of Inflammasome Activation	31
Axes of heterogeneity in human tissue‐resident memory T cells	30
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond	29
PANoptosis: Mechanisms, biology, and role in disease	29
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Modulation of immunity by the secreted phospholipase A2 family	29
Factor D	28
Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammation	28
Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease	28
Cover Image	28
Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma	28
Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy*	27
Structural Immunology of SARS‐CoV‐2	27
Host immune responses in the central nervous system during fungal infections	26
Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic health	26
Development and organization of omental milky spots	25

Understanding inhibitory receptor function in neutrophils through the lens of CLEC12A	25
Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system	25
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Cell type‐specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases	25
Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis	25
Irritable bowel syndrome: When food is a pain in the gut	25
Many Achilles’ heels of B and T cell tolerance	25
Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease	25
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Issue Information	24
Low‐molecular weight inhibitors of the alternative complement pathway	24
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No time to die: Epigenetic regulation of natural killer cell survival	24
Transcriptional and epigenetic regulation in thymic epithelial cells*	23
Stability and change in epigenetic regulation of immune cells	23
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	23
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	23
Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	23
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	22
Innate Immunity and Asthma Exacerbations: Insights From Human Models	22
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	22
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	21
Neutrophils in aging and aging‐related pathologies	21
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	21
Issue Information	21
The nervous system during COVID‐19: Caught in the crossfire	20
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Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	20
Issue Information	20
The impact of the human gut microbiome on the treatment of autoimmune disease	19
Epigenetic regulation of inflammation by CxxC domain‐containing proteins*	19
The impact of neuroinflammation on neuronal integrity	19
Visualization and functional characterization of lymphoid organ fibroblasts*	19
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Regnase‐1–related endoribonucleases in health and immunological diseases	19
ILC2 Diversity, Location, and Function in Pulmonary Disease	19
The evolving landscape of immune‐related adverse events that follow immune checkpoint immunotherapy in cancer patients	19
Signals that control MAIT cell function in healthy and inflamed human tissues	18
Thymflammation: The Role of a Constitutively Active Inflammatory Network and “Ectopic” Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond	18
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	18
Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: Current understanding and future directions	18
Real‐time imaging of inflammation and its resolution: It’s apparent because it’s transparent*	18
Imaging leukocyte migration through afferent lymphatics*	18
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Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo	18
Established and emerging roles for mitochondria in neutrophils	18
Microbes and the fate of neutrophils	17
Innate Immune Receptors as Dynamic Modulators of Extrafollicular Autoimmune B Cell Response	17
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death	17
Innate Immune Sensors in Health and Disease	17
Issue Information	17
Correction to “The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids”	16
Imaging the immune system redux	16
HLA‐E: Immune Receptor Functional Mechanisms Revealed by Structural Studies	16
IgE versus IgG and IgA: Differential roles of allergen‐specific antibodies in sensitization, tolerization, and treatment of allergies	16
Life‐threatening antibodies: The discovery of anaphylaxis	16
Additional Cover	16
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Chemo‐ and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen*	16
Role of B cells in immune‐related adverse events following checkpoint blockade	16
Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches	16
Cover Image	15
Introductory article for Immunological Reviews, Vol 310	15
Role of hormones in the pregnancy and sex‐specific outcomes to infections with respiratory viruses*	15
Tissue‐Resident Th2 Cells in Type 2 Immunity and Allergic Diseases	15
Copper homeostasis and cuproptosis in cancer immunity and therapy	15
Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis	15
Small matters: Introduction to extracellular vesicles	15
Regulation of immune responses to food by commensal microbes	15
The role of dysregulated PI3Kdelta signaling in human autoimmunity*	14
The Immunology of Alpha‐Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat	14
CD4 T cells and toxicity from immune checkpoint blockade	14
Antibodies against endogenous retroviruses	14
The emergence of the calvarial hematopoietic niche in health and disease	13
Issue Information	13
Micro but mighty—Micronutrients in the epigenetic regulation of adaptive immune responses*	13
Severe combined immunodeficiency diagnosis and genetic defects	13
My story of sex, gender, and women's health in a pandemic*	13
Balanced regulation of ROS production and inflammasome activation in preventing early development of colorectal cancer	13

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What sequencing technologies can teach us about innate immunity*	13
Physiology and pathology of the C3 amplification cycle: A retrospective	12
Living in LALA land? Forty years of attenuating Fc effector functions	12
Issue Information	12
Low‐density granulocytes in systemic autoimmunity and autoinflammation	12
Epitope‐Specific Antibodies in Allergic Disease and Clinical Tolerance	12
Spatial determinates of effector and memory CD8+ T cell fates*	12
Stress/cell death pathways, neuroinflammation, and neuropathic pain	12
Molecular determinants of immunogenic cell death elicited by radiation therapy	12
Issue Information	12
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Lessons Learned From Clinical Trials of Immunotherapeutics for COVID‐19	12
A Brief Molecular History of Vγ9Vδ2 TCR‐Mediated Phosphoantigen Sensing	12
Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation	12
The susceptibility of the kidney to alternative pathway activation—A hypothesis	12
Role of inhibitory B cell co‐receptors in B cell self‐tolerance to non‐protein antigens*	12
Whence and wherefore IgE?	12
Intersection of the microbiome and immune metabolism in lupus	12
Moving beyond velocity: Opportunities and challenges to quantify immune cell behavior*	11
LAG Time in the Era of Immunotherapy—New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene‐3	11
Epigenetics and CD8+ T cell memory*	11
At the crux of maternal immune activation: Viruses, microglia, microbes, and IL‐17A	11
NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance*	11
Coengineering specificity, safety, and function into T cells for cancer immunotherapy	11
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Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells	11
Emerging Concepts in Cytokine Regulation of Airway Remodeling in Asthma	11
The Sunrise of Tertiary Lymphoid Structures in Cancer	11
Age‐related macular degeneration: A disease of extracellular complement amplification	11
Regulation of CD8 T‐cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid	11
Unique aspects of IFN‐γ/STAT1 signaling in neurons	11
The resolution of phagosomes	11
Current knowledge on the early stages of human neutropoiesis	11
Engineered exosomes for studies in tumor immunology	11
Established and Emerging Roles of DEAD/H‐Box Helicases in Regulating Infection and Immunity	11
Enhancing Fc‐mediated effector functions of monoclonal antibodies: The example of HexaBodies	11
Cancer immunity by tissue‐resident type 1 innate lymphoid cells and killer innate‐like T cells	10
Coordinated Regulation of Extrafollicular B Cell Responses by IL‐12 and IFNγ	10
Stellabody: A novel hexamer‐promoting mutation for improved IgG potency	10
Maternal IgE Influence on Fetal and Infant Health	10
FOXP3 deficiency, from the mechanisms of the disease to curative strategies	10
Heterogeneity in antiviral B cell responses: Lessons from the movies*	10
Neutrophil‐T cell crosstalk and the control of the host inflammatory response	10
Neutrophil modulation of behavior and cognition in health and disease: The unexplored role of an innate immune cell	10
Early life imprinting of intestinal immune tolerance and tissue homeostasis	10
Transforming mutations in the development of pathogenic B cell clones and autoantibodies*	10
C3‐dependent effector functions of complement	10
IgE in Allergic Diseases	10
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An Outside‐In View of the Beneficial and Detrimental Impact of Type‐2 Inflammation in the Lung	10
Local complement synthesis—A process with near and far consequences for ischemia reperfusion injury and transplantation	10
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Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection*	10
Apoptotic cell clearance components in inflammatory arthritis	10
Eras of designer Tregs: Harnessing synthetic biology for immune suppression	10
Location, Location, Location: Spatial Immune‐Stroma Crosstalk Drives Pathogenesis in Asthma	9
All roads lead to IgA: Mapping the many pathways of IgA induction in the gut	9
Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways	9
The multifaceted life of macrophages in white adipose tissue: Immune shift couples with metabolic switch	9
Advances and challenges in studying the tissue‐resident T cell compartment in the human female reproductive tract	9
Type I interferon and cancer	9
Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop	9
Correction to “The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities”	9
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The Cystic Fibrosis Transmembrane Conductance Receptor Brakes Allergic Airway Inflammation	9
The leukotriene B4 receptors BLT1 and BLT2 as potential therapeutic targets	9
Gene therapy for adenosine deaminase severe combined immune deficiency—An unexpected journey of four decades	9
Using IMGT unique numbering for IG allotypes and Fc‐engineered variants of effector properties and half‐life of therapeutic antibodies	9
Regulation of airway immunity by epithelial miRNAs	9
Functional neutrophil disorders: Chronic granulomatous disease and beyond	9
Get me out of here: Sphingosine 1‐phosphate signaling and T cell exit from tissues during an immune response	9
Information flow in the spatiotemporal organization of immune responses*	9
The complement alternative pathway in health and disease—activation or amplification?	9
Pyroptosis in glioma: Current management and future application	9
Fat‐associated lymphoid clusters: Supporting visceral adipose tissue B cell function in immunity and metabolism	8
Transcriptional and hormonal control of adipose Treg heterogeneity and function	8
Germline mechanisms of immunotherapy toxicities in the era of genome‐wide association studies	8
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Primary and secondary defects of the thymus	8
Epigenetic regulation of natural killer cell memory*	8
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Small particles with large impact: Insights into the unresolved roles of innate immunity in extracellular vesicle‐mediated cardiovascular calcification	8
The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms	8
Maternal‐driven immune education in offspring	8
Decoding immunogenic cell death from a dendritic cell perspective	8
The Factor H protein family: The switchers of the complement alternative pathway	8
Rubella virus chronic inflammatory disease and other unusual viral phenotypes in inborn errors of immunity	8
Thymic Mimetic Cells: Evolutionarily Ancient Mirrors of the Periphery	8
A newborn's perspective on immune responses to food	8
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