Immunological Reviews

Article	Citations
Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance	279
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	238
Issue Information	147
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	100
Metabolic regulation of type I interferon production	95
Immune checkpoint inhibitors in infectious disease	88
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	88
Superoxide: The enigmatic chemical chameleon in neutrophil biology	86
The Structural Biology of T‐Cell Antigen Detection at Close Contacts	80
Imaging dendritic cell functions*	79
Cover Image	75
Antigen‐specific and cross‐reactive T cells in protection and disease	73
NETosis: Sculpting tumor metastasis and immunotherapy	71
Role of inflammasomes and neuroinflammation in epilepsy	67
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease	67
Issue Information	66
Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights	65
The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	65
Allosteric Changes Underlie the Outside‐In Transmission of Activatory Signals in the TCR	64
Thymic and extrathymic Aire‐expressing cells in maternal‐fetal tolerance*	61
The immune system in Down Syndrome: Autoimmunity and severe infections	58
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	57
Layered origins of lymphoid tissue inducer cells	56
The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals	54
B‐1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease	52

With complements: C3 inhibition in the clinic	49
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	48
Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria	48
Mechanisms Promoting Stability of B Cells	47
Autoimmunity and the microbiome	45
Maternal influences on offspring food allergy	45
Issue Information	43
Cover Image	43
Functional Insights From Immunoreceptor Structures	43
Common variable immunodeficiency, cross currents, and prevailing winds	42
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Cortical Thymic Epithelial Cells: Key Developers of the Code of T‐Cell Selection and TCR Repertoire Diversity	41
ZAP70, too little, too much can lead to autoimmunity*	39
Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation	39
Activation pathways that drive CD4+ T cells to break tolerance in autoimmune diseases*	39
Issue Information	39
Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*	38
T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma	38
An introduction to neuroimmunology	38
Issue Information	37
JAK/STAT defects and immune dysregulation, and guiding therapeutic choices	37
Deconstructing the Thymic Microenvironment Through Genesis to Senescence	37
Correction to “The Journey Toward Disease Modification in Cow Milk Protein Allergy”	37
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy	37
Axes of heterogeneity in human tissue‐resident memory T cells	36
Glycobiology of IgE	36
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy	36
Fc‐FcγR interactions during infections: From neutralizing antibodies to antibody‐dependent enhancement	35
Targeting Bottlenecks in Malaria Transmission: Antibody‐Epitope Descriptions Guide the Design of Next‐Generation Biomedical Interventions	35
Human neutrophils ≠ murine neutrophils: Does it matter?	34
Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity	34
Modulation of immunity by the secreted phospholipase A2 family	34
MAP Kinase Signaling at the Crossroads of Inflammasome Activation	33
Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma	33
PANoptosis: Mechanisms, biology, and role in disease	33
Cover Image	33
Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm*	33
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Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy*	32
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond	31
Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammation	31
From Lymphotoxin to Tertiary Lymphoid Structures and Beyond	30
Factor D	30
Development and organization of omental milky spots	29
Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system	29
Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease	29
Cell type‐specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases	29
Structural Immunology of SARS‐CoV‐2	29
Understanding inhibitory receptor function in neutrophils through the lens of CLEC12A	29

Irritable bowel syndrome: When food is a pain in the gut	29
Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease	29
Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis	29
Host immune responses in the central nervous system during fungal infections	29
Many Achilles’ heels of B and T cell tolerance	28
Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic health	28
Issue Information	28
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Cover Image	27
Cover Image	26
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	26
No time to die: Epigenetic regulation of natural killer cell survival	26
Human Atypical B Cells. An Overview	26
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	25
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	25
Transcriptional and epigenetic regulation in thymic epithelial cells*	25
Innate Immunity and Asthma Exacerbations: Insights From Human Models	25
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	25
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	24
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	23
Low‐molecular weight inhibitors of the alternative complement pathway	23
Neutrophils in aging and aging‐related pathologies	23
Stability and change in epigenetic regulation of immune cells	23
The impact of the human gut microbiome on the treatment of autoimmune disease	22
Issue Information	22
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Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	22
Issue Information	22
Visualization and functional characterization of lymphoid organ fibroblasts*	21
The impact of neuroinflammation on neuronal integrity	21
Epigenetic regulation of inflammation by CxxC domain‐containing proteins*	21
The nervous system during COVID‐19: Caught in the crossfire	21
Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	21
Innate Immune Receptors as Dynamic Modulators of Extrafollicular Autoimmune B Cell Response	20
ILC2 Diversity, Location, and Function in Pulmonary Disease	20
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Issue Information	20
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Thymflammation: The Role of a Constitutively Active Inflammatory Network and “Ectopic” Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond	19
Innate Immune Sensors in Health and Disease	19
Real‐time imaging of inflammation and its resolution: It’s apparent because it’s transparent*	19
Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: Current understanding and future directions	19
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death	19
Signals that control MAIT cell function in healthy and inflamed human tissues	19
Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo	19
The evolving landscape of immune‐related adverse events that follow immune checkpoint immunotherapy in cancer patients	18
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Imaging the immune system redux	18
Established and emerging roles for mitochondria in neutrophils	18
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Chemo‐ and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen*	18
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	18
Microbes and the fate of neutrophils	18
Life‐threatening antibodies: The discovery of anaphylaxis	18
Correction to “The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids”	18
HLA‐E: Immune Receptor Functional Mechanisms Revealed by Structural Studies	17
Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches	17
IgE versus IgG and IgA: Differential roles of allergen‐specific antibodies in sensitization, tolerization, and treatment of allergies	17
Additional Cover	17
Regulation of immune responses to food by commensal microbes	17
Role of B cells in immune‐related adverse events following checkpoint blockade	17
Introductory article for Immunological Reviews, Vol 310	16
CD4 T cells and toxicity from immune checkpoint blockade	16
Tissue‐Resident Th2 Cells in Type 2 Immunity and Allergic Diseases	16
Cover Image	16
Copper homeostasis and cuproptosis in cancer immunity and therapy	16
Small matters: Introduction to extracellular vesicles	16
Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis	15
Antibodies against endogenous retroviruses	15
The Immunology of Alpha‐Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat	15
The role of dysregulated PI3Kdelta signaling in human autoimmunity*	15
What sequencing technologies can teach us about innate immunity*	15
Role of hormones in the pregnancy and sex‐specific outcomes to infections with respiratory viruses*	15
Balanced regulation of ROS production and inflammasome activation in preventing early development of colorectal cancer	15
Micro but mighty—Micronutrients in the epigenetic regulation of adaptive immune responses*	14
The emergence of the calvarial hematopoietic niche in health and disease	14
Lessons Learned From Clinical Trials of Immunotherapeutics for COVID‐19	14
Severe combined immunodeficiency diagnosis and genetic defects	14
Issue Information	14
Intersection of the microbiome and immune metabolism in lupus	14

Correction to “The Integrin Receptors: From Discovery to Structure to Medicines”	14
Whence and wherefore IgE?	14
My story of sex, gender, and women's health in a pandemic*	14
Epitope‐Specific Antibodies in Allergic Disease and Clinical Tolerance	13
Physiology and pathology of the C3 amplification cycle: A retrospective	13
Molecular determinants of immunogenic cell death elicited by radiation therapy	13
The susceptibility of the kidney to alternative pathway activation—A hypothesis	13
Issue Information	13
Emerging Concepts in Cytokine Regulation of Airway Remodeling in Asthma	13
Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation	13
Spatial determinates of effector and memory CD8+ T cell fates*	13
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Stress/cell death pathways, neuroinflammation, and neuropathic pain	13
Role of inhibitory B cell co‐receptors in B cell self‐tolerance to non‐protein antigens*	13
Moving beyond velocity: Opportunities and challenges to quantify immune cell behavior*	13
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Low‐density granulocytes in systemic autoimmunity and autoinflammation	13
A Brief Molecular History of Vγ9Vδ2 TCR‐Mediated Phosphoantigen Sensing	13
Issue Information	13
Current knowledge on the early stages of human neutropoiesis	13
Living in LALA land? Forty years of attenuating Fc effector functions	13
The Sunrise of Tertiary Lymphoid Structures in Cancer	12
Coengineering specificity, safety, and function into T cells for cancer immunotherapy	12
Age‐related macular degeneration: A disease of extracellular complement amplification	12
Regulation of CD8 T‐cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid	12
Transforming mutations in the development of pathogenic B cell clones and autoantibodies*	12
Neutrophil modulation of behavior and cognition in health and disease: The unexplored role of an innate immune cell	12
NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance*	12
Established and Emerging Roles of DEAD/H‐Box Helicases in Regulating Infection and Immunity	12
At the crux of maternal immune activation: Viruses, microglia, microbes, and IL‐17A	12
LAG Time in the Era of Immunotherapy—New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene‐3	12
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Enhancing Fc‐mediated effector functions of monoclonal antibodies: The example of HexaBodies	12
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The resolution of phagosomes	12
Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells	12
Epigenetics and CD8+ T cell memory*	12
Local complement synthesis—A process with near and far consequences for ischemia reperfusion injury and transplantation	12
Stellabody: A novel hexamer‐promoting mutation for improved IgG potency	12
An Outside‐In View of the Beneficial and Detrimental Impact of Type‐2 Inflammation in the Lung	12
Engineered exosomes for studies in tumor immunology	12
Unique aspects of IFN‐γ/STAT1 signaling in neurons	11
Maternal IgE Influence on Fetal and Infant Health	11
Early life imprinting of intestinal immune tolerance and tissue homeostasis	11
Coordinated Regulation of Extrafollicular B Cell Responses by IL‐12 and IFNγ	11
Heterogeneity in antiviral B cell responses: Lessons from the movies*	11
Cancer immunity by tissue‐resident type 1 innate lymphoid cells and killer innate‐like T cells	11
Eras of designer Tregs: Harnessing synthetic biology for immune suppression	11
Correction to “The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities”	11
Apoptotic cell clearance components in inflammatory arthritis	11
C3‐dependent effector functions of complement	11
Neutrophil‐T cell crosstalk and the control of the host inflammatory response	11
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IgE in Allergic Diseases	10
Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop	10
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Information flow in the spatiotemporal organization of immune responses*	10
Pyroptosis in glioma: Current management and future application	10
Maternal‐driven immune education in offspring	10
The complement alternative pathway in health and disease—activation or amplification?	10
FOXP3 deficiency, from the mechanisms of the disease to curative strategies	10
All roads lead to IgA: Mapping the many pathways of IgA induction in the gut	10
Using IMGT unique numbering for IG allotypes and Fc‐engineered variants of effector properties and half‐life of therapeutic antibodies	10
Get me out of here: Sphingosine 1‐phosphate signaling and T cell exit from tissues during an immune response	10
Advances and challenges in studying the tissue‐resident T cell compartment in the human female reproductive tract	10
The Factor H protein family: The switchers of the complement alternative pathway	10
Functional neutrophil disorders: Chronic granulomatous disease and beyond	10
Location, Location, Location: Spatial Immune‐Stroma Crosstalk Drives Pathogenesis in Asthma	10
Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection*	10
Gene therapy for adenosine deaminase severe combined immune deficiency—An unexpected journey of four decades	10
The multifaceted life of macrophages in white adipose tissue: Immune shift couples with metabolic switch	10
Decoding immunogenic cell death from a dendritic cell perspective	10
The Cystic Fibrosis Transmembrane Conductance Receptor Brakes Allergic Airway Inflammation	10
A newborn's perspective on immune responses to food	9
Transcriptional and hormonal control of adipose Treg heterogeneity and function	9
Issue Information	9
The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms	9
Small particles with large impact: Insights into the unresolved roles of innate immunity in extracellular vesicle‐mediated cardiovascular calcification	9
Germline mechanisms of immunotherapy toxicities in the era of genome‐wide association studies	9
Primary and secondary defects of the thymus	9
Targeting ferroptosis in gastric cancer: Strategies and opportunities	9
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Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways	9
Type I interferon and cancer	9
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Rubella virus chronic inflammatory disease and other unusual viral phenotypes in inborn errors of immunity	9
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Fat‐associated lymphoid clusters: Supporting visceral adipose tissue B cell function in immunity and metabolism	9
Tertiary Lymphoid Organs at the Center Stage of Skin's Humoral Immunity	9
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The leukotriene B4 receptors BLT1 and BLT2 as potential therapeutic targets	9
Issue Information	9
Intracellular complement: Evidence, definitions, controversies, and solutions	9
Issue Information	9
Epigenetic regulation of natural killer cell memory*	9