Immunological Reviews

Article	Citations
Immunometabolism: From basic mechanisms to translation	207
The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)	202
The role of host genetics in the immune response to SARS‐CoV‐2 and COVID‐19 susceptibility and severity	166
Correlates of protection against SARS‐CoV‐2 infection and COVID‐19 disease	138
Immunological memory to SARS‐CoV‐2 infection and COVID‐19 vaccines	136
Therapeutic modulation of inflammasome pathways	129
COVID‐19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts	120
Role of cancer‐associated fibroblast subpopulations in immune infiltration, as a new means of treatment in cancer	111
AIM2 in health and disease: Inflammasome and beyond	104
The NLRP1 and CARD8 inflammasomes	100
The molecular mechanism of RIG‐I activation and signaling	94
T follicular helper cells in germinal center B cell selection and lymphomagenesis	90
Cancer‐associated fibroblasts: Key players in shaping the tumor immune microenvironment	84
The inflammatory speech of fibroblasts	78
NOD1 and NOD2 in inflammatory and infectious diseases	76
Regulatory B cells in cancer	75
Host‐directed therapy to combat mycobacterial infections*	69
The role of innate immunity in Alzheimer's disease	68
Memory B cells and plasma cells: The differentiative continuum of humoral immunity	67
Adipose tissue macrophages: Unique polarization and bioenergetics in obesity	66
Lipids, inflammasomes, metabolism, and disease	59
Fibroblasts as confederates of the immune system	58
The 3Ds in virus‐like particle based‐vaccines: “Design, Delivery and Dynamics”	57
Factors in B cell competition and immunodominance	57
Molecular mechanisms activating the NAIP‐NLRC4 inflammasome: Implications in infectious disease, autoinflammation, and cancer	57

Modulation of immune responses using adjuvants to facilitate therapeutic vaccination	55
The role of B cell antigen presentation in the initiation of CD4+ T cell response	52
Intracellular innate immune receptors: Life inside the cell	51
Novel mechanisms and clinical trial endpoints in intestinal fibrosis*	47
Innate and adaptive γδ T cells: How, when, and why	46
Cell‐intrinsic metabolic regulation of mononuclear phagocyte activation: Findings from the tip of the iceberg	45
Microbiome, bile acids, and obesity: How microbially modified metabolites shape anti‐tumor immunity	43
Imprinting, immunodominance, and other impediments to generating broad influenza immunity	42
Control of foreign Ag‐specific Ab responses by Treg and Tfr	41
Cross talk between intracellular pathogens and cell death	41
Regulatory B cells: TIM‐1, transplant tolerance, and rejection	41
T peripheral helper cells in autoimmune diseases*	40
From thymus to periphery: Molecular basis of effector γδ‐T cell differentiation	40
How intrinsic and extrinsic regulators of plasma cell survival might intersect for durable humoral immunity	39
Immune dynamics in the CNS and its barriers during homeostasis and disease*	39
Not too fat to fight: The emerging role of macrophage fatty acid metabolism in immunity to Mycobacterium tuberculosis	39
Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection*	38
Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammation	38
A century of BCG: Impact on tuberculosis control and beyond	36
Classical CD4 T cells as the cornerstone of antimycobacterial immunity	34
Molecular mechanisms controlling age‐associated B cells in autoimmunity*	34
Transcriptional regulation of adaptive and innate lymphoid lineage specification	33
Tumor resistance mechanisms and their consequences on γδ T cell activation	33
In search of biomarkers for leprosy by unraveling the host immune response to Mycobacterium leprae	32
The microbiome and cytosolic innate immune receptors	31
Pyroptotic and non‐pyroptotic effector functions of caspase‐11	31
Guardians of the oral and nasopharyngeal galaxy: IgA and protection against SARS‐CoV‐2 infection*	31
Fantastic IgA plasma cells and where to find them	30
Fibroblasts and macrophages: Collaborators in tissue homeostasis	29
Age‐related factors that affect B cell responses to vaccination in mice and humans	29
The distinct MHC‐unrestricted immunobiology of innate‐like and adaptive‐like human γδ T cell subsets—Nature's CAR‐T cells	29
Monocytes and macrophages in pregnancy: The good, the bad, and the ugly*	28
Gut γδ T cells as guardians, disruptors, and instigators of cancer	28
The geography of memory B cell reactivation in vaccine‐induced immunity and in autoimmune disease relapses	27
Diversity in recognition and function of human γδ T cells	27
COVID‐19 and plasma cells: Is there long‐lived protection?*	26
Fibroblast pathology in inflammatory joint disease	26
Established and emergent roles for Ikaros transcription factors in lymphoid cell development and function	25
Know your enemy or find your friend?—Induction of IgA at mucosal surfaces	25
BCG‐induced protection against Mycobacterium tuberculosis infection: Evidence, mechanisms, and implications for next‐generation vaccines	25
Differentiation and activation of fibroblastic reticular cells	24
Plasma cell survival: The intrinsic drivers, migratory signals, and extrinsic regulators	24
Nuclear innate sensors for nucleic acids in immunity and inflammation	23
B regulatory cells in allergy	22
Next generation of immune checkpoint molecules in maternal‐fetal immunity*	22
Imaging dendritic cell functions*	22
Regulatory B cells in respiratory health and diseases	22
γδ T cells and inflammatory skin diseases	22
Protective neutralizing epitopes in SARS‐CoV‐2	22
A bird’s eye view of fibroblast heterogeneity: A pan‐disease, pan‐cancer perspective	22

The Factor H protein family: The switchers of the complement alternative pathway	21
Two functionally distinct subsets of IL‐17 producing γδ T cells	21
Epigenetics and CD8+ T cell memory*	21
T cell help to B cells: Cognate and atypical interactions in peripheral and intestinal lymphoid tissues	21
Emerging roles for endogenous retroviruses in immune epigenetic regulation*	20
Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm*	20
A glance over the fence: Using phylogeny and species comparison for a better understanding of antigen recognition by human γδ T‐cells	20
The three as: Alternative splicing, alternative polyadenylation and their impact on apoptosis in immune function	20
The pyrin inflammasome and the Yersinia effector interaction	20
Novel Frontiers in Regulatory B cells	20
Human neutrophils ≠ murine neutrophils: Does it matter?	20
Macrophage‐fibroblast circuits in the spleen	20
Extracellular vesicles in atherothrombosis: From biomarkers and precision medicine to therapeutic targets	19
Activation pathways that drive CD4+ T cells to break tolerance in autoimmune diseases*	19
ZAP70, too little, too much can lead to autoimmunity*	19
The role of donor‐unrestricted T‐cells, innate lymphoid cells, and NK cells in anti‐mycobacterial immunity	19
Regulation of neuroinflammation by B cells and plasma cells	19
The role of neutrophils in trained immunity	19
Signals 1, 2 and B cell fate or: Where, when and for how long?	19
Circulating tissue factor‐positive extracellular vesicles and their association with thrombosis in different diseases	18
Reduction of host cell mitochondrial activity as Mycobacterium leprae’s strategy to evade host innate immunity	18
Engineered exosomes for studies in tumor immunology	18
The gene regulatory network controlling plasma cell function	18
Deciphering human γδ T cell response in cancer: Lessons from tumor‐infiltrating γδ T cells	18
Immunity against Mycobacterium ulcerans: The subversive role of mycolactone	17
Neutrophils in aging and aging‐related pathologies	17
Epigenetic regulation of natural killer cell memory*	17
Immune recognition of phosphoantigen‐butyrophilin molecular complexes by γδ T cells	17
B‐cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human B cells*	17
Epigenetic regulation of T cell adaptive immunity	17
Neutrophil‐T cell crosstalk and the control of the host inflammatory response	17
Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy*	17
Transcriptomics for child and adolescent tuberculosis*	16
N1 versus N2 and PMN‐MDSC: A critical appraisal of current concepts on tumor‐associated neutrophils and new directions for human oncology	16
Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways	16
C3‐dependent effector functions of complement	16
γδ T cell migration: Separating trafficking from surveillance behaviors at barrier surfaces	16
How RNA modifications regulate the antiviral response	16
Platelet extracellular vesicles and the secretory interactome join forces in health and disease	15
The fibroblast: An emerging key player in thymic T cell selection	15
Susceptibility and resistance in leprosy: Studies in the mouse model	15
Conversations that count: Cellular interactions that drive T cell fate	15
Perivascular stromal cells: Directors of tissue immune niches	15
Cancer immunotherapy harnessing γδ T cells and programmed death‐1	15
Fueling influenza and the immune response: Implications for metabolic reprogramming during influenza infection and immunometabolism	14
Transcriptional and epigenetic regulation of memory NK cell responses	14
Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells	14
On the road to eliminating long‐lived plasma cells—“are we there yet?”	14
Reconciling protective and pathogenic roles of the NLRP3 inflammasome in leishmaniasis	14
Influenza vaccination strategies targeting the hemagglutinin stem region	14
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	14
Role of inhibitory signaling in peripheral B cell tolerance*	14
Extracellular vesicles and immune response during pregnancy: A balancing act*	13
Real‐time imaging of inflammation and its resolution: It’s apparent because it’s transparent*	13
RNA regulatory mechanisms that control antiviral innate immunity	13
The special unfolded protein response in plasma cells	13
Fibroblast heterogeneity and tertiary lymphoid tissues in the kidney	13
Genetic variability shapes the alternative pathway complement activity and predisposition to complement‐related diseases	13
Intracellular complement: Evidence, definitions, controversies, and solutions	13
The formation and function of the neutrophil phagosome	13
Runx proteins and transcriptional mechanisms that govern memory CD8 T cell development	13
Fast‐acting γδ T‐cell subpopulation and protective immunity against infections	12
MicroRNA regulation of B cell receptor signaling	12
Immunoregulation by antibody secreting cells in inflammation, infection, and cancer	12
Unique aspects of IFN‐γ/STAT1 signaling in neurons	12
Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	12
Biochemical coordination of plasma cell genesis	12
Roadmap to a plasma cell: Epigenetic and transcriptional cues that guide B cell differentiation	12
Human antiviral B cell responses: Emerging lessons from hepatitis B and COVID‐19	12
Neutrophils as immune effector cells in antibody therapy in cancer	12
Targetability of the neurovascular unit in inflammatory diseases of the central nervous system	12
Secret messengers: Extracellular RNA communication in the immune system	12
B cell/stromal cell crosstalk in health, disease, and treatment: Follicular lymphoma as a paradigm	12
Stromal cells in tertiary lymphoid structures: Architects of autoimmunity	12
Cell fate dynamics and genomic programming of plasma cell precursors	11
Sequence determinants as key regulators in gene expression of T cells	11
The role of efferocytosis‐fueled macrophage metabolism in the resolution of inflammation	11
The emerging role for metabolism in fueling neutrophilic inflammation	11
Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*	11
Regnase‐1–related endoribonucleases in health and immunological diseases	11

Chemo‐ and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen*	11
The complement alternative pathway and hemostasis	11
Cell‐intrinsic and ‐extrinsic roles of miRNAs in regulating T cell immunity	11
Senescent T cells: Beneficial and detrimental roles	10
Imaging reveals novel innate immune responses in lung, liver, and beyond*	10
At the crux of maternal immune activation: Viruses, microglia, microbes, and IL‐17A	10
Imaging innate immunity*	10
Role of hormones in the pregnancy and sex‐specific outcomes to infections with respiratory viruses*	10
AIRE in context: Leveraging chromatin plasticity to trigger ectopic gene expression*	10
Primary immunodeficiencies in cytosolic pattern‐recognition receptor pathways: Toward host‐directed treatment strategies	10
Immunity at maternal–fetal interface: KIR/HLA (Allo)recognition*	10
Single‐cell advances in stromal‐leukocyte interactions in cancer	10
Signaling‐to‐chromatin pathways in the immune system	10
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	10
Engineering the IL‐4/IL‐13 axis for targeted immune modulation	9
Gene targeting as a therapeutic avenue in diseases mediated by the complement alternative pathway	9
Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis	9
With complements: C3 inhibition in the clinic	9
Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop	9
The nervous system during COVID‐19: Caught in the crossfire	9
Interaction between γδTCR signaling and the E protein‐Id axis in γδ T cell development	9
The complement alternative pathway in paroxysmal nocturnal hemoglobinuria: From a pathogenic mechanism to a therapeutic target	9
Fetal‐placental antigens and the maternal immune system: Reproductive immunology comes of age*	9
Epigenetic gene regulation in plasma cells	9
Diving into the mechanism of action of tumor immunotherapies with intravital imaging*	9
Age‐related macular degeneration: A disease of extracellular complement amplification	9
Initiation of the alternative pathway of complement and the history of “tickover”	9
Understanding human γδ T cell biology toward a better management of cytomegalovirus infection	9
Developmental changes in the rules for B cell selection	9
The expanding family of neutrophil‐derived extracellular vesicles	9
Visualization and functional characterization of lymphoid organ fibroblasts*	9
Mast cell ontogeny: From fetal development to life‐long health and disease	9
Deciphering the multifaceted roles of TET proteins in T‐cell lineage specification and malignant transformation	9
Micro but mighty—Micronutrients in the epigenetic regulation of adaptive immune responses*	8
Heterogeneity in IgG‐CD16 signaling in infectious disease outcomes*	8
Amplifying “eat me signal” by immunogenic cell death for potentiating cancer immunotherapy	8
Ontogeny and heterogeneity of innate lymphoid cells and the noncoding genome	8
Ferroptosis in immunostimulation and immunosuppression	8
Established and emerging roles for mitochondria in neutrophils	8
Lipid metabolism in dendritic cell biology	8
Antigen‐specific and cross‐reactive T cells in protection and disease	8
The neutrophil: A key resourceful agent in immune‐mediated vasculitis	8
Silencing and activating anergic B cells*	8
Neutrophils during SARS‐CoV‐2 infection: Friend or foe?	8
Neutrophil modulation of behavior and cognition in health and disease: The unexplored role of an innate immune cell	8
Low‐molecular weight inhibitors of the alternative complement pathway	8
Beyond CAR T cells: Engineered Vγ9Vδ2 T cells to fight solid tumors	8
Transforming mutations in the development of pathogenic B cell clones and autoantibodies*	7
Epigenetic regulation of inflammation by CxxC domain‐containing proteins*	7
Transcriptional and epigenetic regulation in thymic epithelial cells*	7
Neutrophils are gatekeepers of mucosal immunity	7
Type I interferon and cancer	7
Neuroinflammation: Extinguishing a blaze of T cells	7
Chromodomain helicase DNA‐binding 4 (CHD4) regulates early B cell identity and V(D)J recombination*	7
GPR35 and mediators from platelets and mast cells in neutrophil migration and inflammation	7
Effects of immune‐related adverse events (irAEs) and their treatment on antitumor immune responses	7
Kidney diseases	7
Insights into phenotypic and functional CD8+ TRM heterogeneity	7
NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance*	7
Tissue‐resident memory T cells and lung immunopathology	7
Remodeling the chromatin landscape in T lymphocytes by a division of labor among transcription factors	7
The layered development of mouse B and T Cells	6
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond	6
Modulation of immunity by the secreted phospholipase A2 family	6
Information flow in the spatiotemporal organization of immune responses*	6
Exploring epigenetic reprogramming during central nervous system infection	6
Epigenetics and tissue immunity—Translating environmental cues into functional adaptations*	6
Moving beyond velocity: Opportunities and challenges to quantify immune cell behavior*	6
Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system	6
Application of a portable instrument for rapid and reliable detection of SARS‐CoV‐2 infection in any environment	6
Challenges and solutions for therapeuticTCR‐based agents	6
The coming of age of neutrophil extracellular traps in thrombosis: Where are we now and where are we headed?	6
Imaging leukocyte migration through afferent lymphatics*	6
The double‐edged sword of Tregs in M tuberculosis, M avium, and M. abscessus infection	6
Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation	6
Low‐density granulocytes in systemic autoimmunity and autoinflammation	6
RNA‐binding proteins and RNA methylation in myeloid cells	6
Neuroimmune signaling at the brain borders	6
T cell activation niches—Optimizing T cell effector function in inflamed and infected tissues*	6
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	6
Routine SARS‐CoV‐2 vaccination for all children*	6
Surfing on the waves of the human γδ T cell ontogenic sea	5
In search of lost time: Enhancers as modulators of timing in lymphocyte development and differentiation	5
Determinants, mechanisms, and functional outcomes of myeloid cell diversity in cancer	5
Alternative pathway diagnostics	5
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	5
Regulatory strategies limiting endosomal Toll‐like receptor activation in B cells*	5
Superoxide: The enigmatic chemical chameleon in neutrophil biology	5
Get me out of here: Sphingosine 1‐phosphate signaling and T cell exit from tissues during an immune response	5
Microbes and the fate of neutrophils	5
Inside the phagosome: A bacterial perspective	5
Imaging the different timescales of germinal center selection*	5
Axes of heterogeneity in human tissue‐resident memory T cells	5
Harnessing the power of artificial intelligence to advance cell therapy	5
Alternative pathway amplification and infections	5