Immunological Reviews

Article	Citations
Correlates of protection against SARS‐CoV‐2 infection and COVID‐19 disease	189
Immunological memory to SARS‐CoV‐2 infection and COVID‐19 vaccines	177
COVID‐19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts	134
Role of cancer‐associated fibroblast subpopulations in immune infiltration, as a new means of treatment in cancer	134
The molecular mechanism of RIG‐I activation and signaling	124
Cancer‐associated fibroblasts: Key players in shaping the tumor immune microenvironment	103
The inflammatory speech of fibroblasts	96
Regulatory B cells in cancer	94
Memory B cells and plasma cells: The differentiative continuum of humoral immunity	88
Host‐directed therapy to combat mycobacterial infections*	84
Fibroblasts as confederates of the immune system	68
Novel mechanisms and clinical trial endpoints in intestinal fibrosis*	62
Innate and adaptive γδ T cells: How, when, and why	59
T peripheral helper cells in autoimmune diseases*	56
Not too fat to fight: The emerging role of macrophage fatty acid metabolism in immunity to Mycobacterium tuberculosis	53
Regulatory B cells: TIM‐1, transplant tolerance, and rejection	50
Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammation	49
From thymus to periphery: Molecular basis of effector γδ‐T cell differentiation	49
Immune dynamics in the CNS and its barriers during homeostasis and disease*	49
A century of BCG: Impact on tuberculosis control and beyond	45
Molecular mechanisms controlling age‐associated B cells in autoimmunity*	42
Guardians of the oral and nasopharyngeal galaxy: IgA and protection against SARS‐CoV‐2 infection*	41
Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection*	41
Classical CD4 T cells as the cornerstone of antimycobacterial immunity	40
Monocytes and macrophages in pregnancy: The good, the bad, and the ugly*	37

Fantastic IgA plasma cells and where to find them	37
Neutrophils in aging and aging‐related pathologies	36
In search of biomarkers for leprosy by unraveling the host immune response to Mycobacterium leprae	36
Fibroblasts and macrophages: Collaborators in tissue homeostasis	36
Transcriptional regulation of adaptive and innate lymphoid lineage specification	34
Fibroblast pathology in inflammatory joint disease	33
BCG‐induced protection against Mycobacterium tuberculosis infection: Evidence, mechanisms, and implications for next‐generation vaccines	33
The role of neutrophils in trained immunity	32
COVID‐19 and plasma cells: Is there long‐lived protection?*	32
The Factor H protein family: The switchers of the complement alternative pathway	31
Diversity in recognition and function of human γδ T cells	31
Know your enemy or find your friend?—Induction of IgA at mucosal surfaces	30
Plasma cell survival: The intrinsic drivers, migratory signals, and extrinsic regulators	30
Protective neutralizing epitopes in SARS‐CoV‐2	30
C3‐dependent effector functions of complement	30
Differentiation and activation of fibroblastic reticular cells	30
Imaging dendritic cell functions*	30
Regulatory B cells in respiratory health and diseases	29
Human neutrophils ≠ murine neutrophils: Does it matter?	29
Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy*	29
Established and emergent roles for Ikaros transcription factors in lymphoid cell development and function	29
The three as: Alternative splicing, alternative polyadenylation and their impact on apoptosis in immune function	28
Emerging roles for endogenous retroviruses in immune epigenetic regulation*	27
A bird’s eye view of fibroblast heterogeneity: A pan‐disease, pan‐cancer perspective	26
Next generation of immune checkpoint molecules in maternal‐fetal immunity*	26
B regulatory cells in allergy	26
Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm*	26
N1 versus N2 and PMN‐MDSC: A critical appraisal of current concepts on tumor‐associated neutrophils and new directions for human oncology	25
Extracellular vesicles in atherothrombosis: From biomarkers and precision medicine to therapeutic targets	25
The role of efferocytosis‐fueled macrophage metabolism in the resolution of inflammation	25
Epigenetics and CD8+ T cell memory*	24
Circulating tissue factor‐positive extracellular vesicles and their association with thrombosis in different diseases	24
Macrophage‐fibroblast circuits in the spleen	24
Activation pathways that drive CD4+ T cells to break tolerance in autoimmune diseases*	23
Neutrophil‐T cell crosstalk and the control of the host inflammatory response	23
Novel Frontiers in Regulatory B cells	23
ZAP70, too little, too much can lead to autoimmunity*	23
Engineering the IL‐4/IL‐13 axis for targeted immune modulation	23
Unique aspects of IFN‐γ/STAT1 signaling in neurons	23
The gene regulatory network controlling plasma cell function	22
The role of donor‐unrestricted T‐cells, innate lymphoid cells, and NK cells in anti‐mycobacterial immunity	22
Ferroptosis in immunostimulation and immunosuppression	21
Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways	21
Platelet extracellular vesicles and the secretory interactome join forces in health and disease	21
Transcriptomics for child and adolescent tuberculosis*	21
Copper homeostasis and cuproptosis in cancer immunity and therapy	21
PANoptosis: Mechanisms, biology, and role in disease	20
Neutrophils as immune effector cells in antibody therapy in cancer	20
B‐cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human B cells*	20
Type I interferon and cancer	20

Engineered exosomes for studies in tumor immunology	20
Epigenetic regulation of natural killer cell memory*	20
Mast cell ontogeny: From fetal development to life‐long health and disease	20
Amplifying “eat me signal” by immunogenic cell death for potentiating cancer immunotherapy	20
Susceptibility and resistance in leprosy: Studies in the mouse model	20
The emerging role for metabolism in fueling neutrophilic inflammation	19
The complement alternative pathway and hemostasis	19
Epigenetic regulation of T cell adaptive immunity	19
Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells	19
Tissue‐resident memory T cells and lung immunopathology	19
Conversations that count: Cellular interactions that drive T cell fate	19
The complement alternative pathway in paroxysmal nocturnal hemoglobinuria: From a pathogenic mechanism to a therapeutic target	18
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	18
How RNA modifications regulate the antiviral response	18
Reduction of host cell mitochondrial activity as Mycobacterium leprae’s strategy to evade host innate immunity	18
Stromal cells in tertiary lymphoid structures: Architects of autoimmunity	18
The fibroblast: An emerging key player in thymic T cell selection	18
Targetability of the neurovascular unit in inflammatory diseases of the central nervous system	18
The formation and function of the neutrophil phagosome	18
Perivascular stromal cells: Directors of tissue immune niches	17
Extracellular vesicles and immune response during pregnancy: A balancing act*	17
Secret messengers: Extracellular RNA communication in the immune system	17
Immunity against Mycobacterium ulcerans: The subversive role of mycolactone	17
Modulation of immunity by the secreted phospholipase A2 family	17
Initiation of the alternative pathway of complement and the history of “tickover”	16
Transcriptional and epigenetic regulation of memory NK cell responses	16
Real‐time imaging of inflammation and its resolution: It’s apparent because it’s transparent*	16
Runx proteins and transcriptional mechanisms that govern memory CD8 T cell development	16
Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation	16
Harnessing the power of artificial intelligence to advance cell therapy	16
Role of inhibitory signaling in peripheral B cell tolerance*	16
Intracellular complement: Evidence, definitions, controversies, and solutions	15
Neutrophils during SARS‐CoV‐2 infection: Friend or foe?	15
Fibroblast heterogeneity and tertiary lymphoid tissues in the kidney	15
RNA regulatory mechanisms that control antiviral innate immunity	15
Effects of immune‐related adverse events (irAEs) and their treatment on antitumor immune responses	15
The special unfolded protein response in plasma cells	15
With complements: C3 inhibition in the clinic	15
Insights into phenotypic and functional CD8+ TRM heterogeneity	15
Role of hormones in the pregnancy and sex‐specific outcomes to infections with respiratory viruses*	15
Sequence determinants as key regulators in gene expression of T cells	15
Regnase‐1–related endoribonucleases in health and immunological diseases	15
Genetic variability shapes the alternative pathway complement activity and predisposition to complement‐related diseases	15
Gene targeting as a therapeutic avenue in diseases mediated by the complement alternative pathway	14
The coming of age of neutrophil extracellular traps in thrombosis: Where are we now and where are we headed?	14
Cell‐intrinsic and ‐extrinsic roles of miRNAs in regulating T cell immunity	14
Age‐related macular degeneration: A disease of extracellular complement amplification	14
MicroRNA regulation of B cell receptor signaling	14
Human antiviral B cell responses: Emerging lessons from hepatitis B and COVID‐19	14
Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	14
Immunity at maternal–fetal interface: KIR/HLA (Allo)recognition*	14
On the road to eliminating long‐lived plasma cells—“are we there yet?”	14
B cell/stromal cell crosstalk in health, disease, and treatment: Follicular lymphoma as a paradigm	14
The neutrophil: A key resourceful agent in immune‐mediated vasculitis	14
Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system	13
Imaging reveals novel innate immune responses in lung, liver, and beyond*	13
Cell fate dynamics and genomic programming of plasma cell precursors	13
At the crux of maternal immune activation: Viruses, microglia, microbes, and IL‐17A	13
Biochemical coordination of plasma cell genesis	13
Roadmap to a plasma cell: Epigenetic and transcriptional cues that guide B cell differentiation	13
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	12
Low‐density granulocytes in systemic autoimmunity and autoinflammation	12
Senescent T cells: Beneficial and detrimental roles	12
The expanding family of neutrophil‐derived extracellular vesicles	12
Surfing on the waves of the human γδ T cell ontogenic sea	12
Low‐molecular weight inhibitors of the alternative complement pathway	12
Imaging innate immunity*	12
Fetal‐placental antigens and the maternal immune system: Reproductive immunology comes of age*	12
Signaling‐to‐chromatin pathways in the immune system	12
Lipid metabolism in dendritic cell biology	12
Single‐cell advances in stromal‐leukocyte interactions in cancer	12
Immunoregulation by antibody secreting cells in inflammation, infection, and cancer	12
Visualization and functional characterization of lymphoid organ fibroblasts*	12
TAM receptors in phagocytosis: Beyond the mere internalization of particles	11
Chemo‐ and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen*	11
Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*	11
Next‐generation chimeric antigen receptors for T‐ and natural killer‐cell therapies against cancer	11
Stress/cell death pathways, neuroinflammation, and neuropathic pain	11
AIRE in context: Leveraging chromatin plasticity to trigger ectopic gene expression*	11
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy	11

Antigen‐specific and cross‐reactive T cells in protection and disease	11
Factor D	11
Developmental changes in the rules for B cell selection	11
The nervous system during COVID‐19: Caught in the crossfire	11
Deciphering the multifaceted roles of TET proteins in T‐cell lineage specification and malignant transformation	11
Speed and navigation control of thymocyte development by the fetal T‐cell gene regulatory network	10
Microbes and the fate of neutrophils	10
Epigenetic gene regulation in plasma cells	10
The metabolic characteristic of decidual immune cells and their unique properties in pregnancy loss*	10
Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis	10
Challenges and solutions for therapeuticTCR‐based agents	10
Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop	10
NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance*	10
Antibody‐mediated phagocytosis in cancer immunotherapy	10
Advances and challenges in studying the tissue‐resident T cell compartment in the human female reproductive tract	10
Heterogeneity in IgG‐CD16 signaling in infectious disease outcomes*	10
Established and emerging roles for mitochondria in neutrophils	10
Superoxide: The enigmatic chemical chameleon in neutrophil biology	10
Micro but mighty—Micronutrients in the epigenetic regulation of adaptive immune responses*	10
Molecular determinants of immunogenic cell death elicited by radiation therapy	9
Trained immunity: General and emerging concepts	9
Introduction to the immunology of pregnancy	9
Transforming mutations in the development of pathogenic B cell clones and autoantibodies*	9
The layered development of mouse B and T Cells	9
GPR35 and mediators from platelets and mast cells in neutrophil migration and inflammation	9
Get me out of here: Sphingosine 1‐phosphate signaling and T cell exit from tissues during an immune response	9
Functional heterogeneity of human skin‐resident memory T cells in health and disease	9
Neutrophil modulation of behavior and cognition in health and disease: The unexplored role of an innate immune cell	9
Neutrophils are gatekeepers of mucosal immunity	9
Biomarkers of immune checkpoint inhibitor response and toxicity: Challenges and opportunities	9
Kidney diseases	9
Diving into the mechanism of action of tumor immunotherapies with intravital imaging*	9
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	9
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	8
Eras of designer Tregs: Harnessing synthetic biology for immune suppression	8
Ontogeny and heterogeneity of innate lymphoid cells and the noncoding genome	8
Silencing and activating anergic B cells*	8
Immune‐related adverse events after immune check point inhibitors: Understanding the intersection with autoimmunity	8
Epigenetics and tissue immunity—Translating environmental cues into functional adaptations*	8
Epigenetic regulation of inflammation by CxxC domain‐containing proteins*	8
Coengineering specificity, safety, and function into T cells for cancer immunotherapy	8
The susceptibility of the kidney to alternative pathway activation—A hypothesis	8
Remodeling the chromatin landscape in T lymphocytes by a division of labor among transcription factors	8
Information flow in the spatiotemporal organization of immune responses*	8
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	8
Neuroinflammation: Extinguishing a blaze of T cells	8
Chromodomain helicase DNA‐binding 4 (CHD4) regulates early B cell identity and V(D)J recombination*	8
Using immunogenic cell death to improve anticancer efficacy of immune checkpoint inhibitors: From basic science to clinical application	8
RNA‐binding proteins and RNA methylation in myeloid cells	8
Imaging leukocyte migration through afferent lymphatics*	8
Shaping immunity for life: Layered development of CD8+ T cells	7
Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity	7
Inside the phagosome: A bacterial perspective	7
Immunogenic cell death (ICD) enhancers—Drugs that enhance the perception of ICD by dendritic cells	7
Spatial determinates of effector and memory CD8+ T cell fates*	7
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond	7
T cell activation niches—Optimizing T cell effector function in inflamed and infected tissues*	7
Transcriptional and epigenetic regulation in thymic epithelial cells*	7
Multiple waves of fetal‐derived immune cells constitute adult immune system	7
The emergence of the calvarial hematopoietic niche in health and disease	7
T‐cell heterogeneity, progenitor–progeny relationships, and function during latent and chronic viral infections	7
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	7
Regulatory strategies limiting endosomal Toll‐like receptor activation in B cells*	6
Routine SARS‐CoV‐2 vaccination for all children*	6
Role of inhibitory B cell co‐receptors in B cell self‐tolerance to non‐protein antigens*	6
B cells going viral in theCNS: Dynamics, complexities, and functions of B cells responding to viral encephalitis	6
Spatiotemporally programming cytokine immunotherapies through protein engineering	6
CD4 T cells and toxicity from immune checkpoint blockade	6
Autoimmunity in immune checkpoint inhibitor‐induced immune‐related adverse events: A focus on autoimmune skin toxicity and pneumonitis	6
Neuroimmune signaling at the brain borders	6
Alternative pathway amplification and infections	6
The double‐edged sword of Tregs in M tuberculosis, M avium, and M. abscessus infection	6
Imaging the different timescales of germinal center selection*	6
Metabolic regulation of type I interferon production	6
Mediators and mechanisms of immune checkpoint inhibitor‐associated myocarditis: Insights from mouse and human	6
Hijacking homeostasis: Regulation of the tumor microenvironment by apoptosis	6
Emerging roles of lysophosphatidylserine as an immune modulator	6
Applications of CRISPR technology in cellular immunotherapy	6
Exploring epigenetic reprogramming during central nervous system infection	6
Plasma cell biology: Foundations for targeted therapeutic development in transplantation	6
In search of lost time: Enhancers as modulators of timing in lymphocyte development and differentiation	6
Moving beyond velocity: Opportunities and challenges to quantify immune cell behavior*	6
Targeting ferroptosis in gastric cancer: Strategies and opportunities	6
Axes of heterogeneity in human tissue‐resident memory T cells	6
Alternative pathway activation: Ever ancient and ever new	6
Apoptotic cell clearance components in inflammatory arthritis	6
Memory CD8+ T cell‐mediated protection against liver‐stage malaria	5
The cell stress and immunity cycle in cancer: Toward next generation of cancer immunotherapy	5
Memories that last: Dynamics of memory T cells throughout the body	5
Alternative pathway diagnostics	5
NETosis: Sculpting tumor metastasis and immunotherapy	5
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	5
Layered origins of lymphoid tissue inducer cells	5
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	5
The discovery of NLRP3 and its function in cryopyrin‐associated periodic syndromes and innate immunity	5