Immunological Reviews

Article	Citations
Issue Information	240
Cover Image	213
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease	162
Issue Information	149
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	148
Immune checkpoint inhibitors in infectious disease	132
The Structural Biology of T‐Cell Antigen Detection at Close Contacts	130
Role of inflammasomes and neuroinflammation in epilepsy	116
Antigen‐specific and cross‐reactive T cells in protection and disease	83
Imaging dendritic cell functions*	80
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	76
Cell‐intrinsic and ‐extrinsic roles of miRNAs in regulating T cell immunity	71
Superoxide: The enigmatic chemical chameleon in neutrophil biology	68
NETosis: Sculpting tumor metastasis and immunotherapy	63
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	60
Metabolic regulation of type I interferon production	59
Issue Information	58
The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	53
Thymic and extrathymic Aire‐expressing cells in maternal‐fetal tolerance*	51
Allosteric Changes Underlie the Outside‐In Transmission of Activatory Signals in the TCR	49
Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria	49
Layered origins of lymphoid tissue inducer cells	48
With complements: C3 inhibition in the clinic	47
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	47
Fibroblasts and macrophages: Collaborators in tissue homeostasis	47

B‐1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease	46
Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights	46
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	45
Cover Image	45
The immune system in Down Syndrome: Autoimmunity and severe infections	45
The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals	45
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Autoimmunity and the microbiome	44
An introduction to neuroimmunology	40
Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation	40
Common variable immunodeficiency, cross currents, and prevailing winds	40
Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*	40
T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma	39
Sequence determinants as key regulators in gene expression of T cells	39
Diving into the mechanism of action of tumor immunotherapies with intravital imaging*	38
Issue Information	37
ZAP70, too little, too much can lead to autoimmunity*	36
Issue Information	35
Activation pathways that drive CD4+ T cells to break tolerance in autoimmune diseases*	35
Maternal influences on offspring food allergy	35
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Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy	34
JAK/STAT defects and immune dysregulation, and guiding therapeutic choices	32
Targeting Bottlenecks in Malaria Transmission: Antibody‐Epitope Descriptions Guide the Design of Next‐Generation Biomedical Interventions	32
Fc‐FcγR interactions during infections: From neutralizing antibodies to antibody‐dependent enhancement	32
Correction to “The Journey Toward Disease Modification in Cow Milk Protein Allergy”	32
Issue Information	32
Axes of heterogeneity in human tissue‐resident memory T cells	32
Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm*	31
Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity	31
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy	31
MAP Kinase Signaling at the Crossroads of Inflammasome Activation	31
Modulation of immunity by the secreted phospholipase A2 family	31
PANoptosis: Mechanisms, biology, and role in disease	31
Human neutrophils ≠ murine neutrophils: Does it matter?	30
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond	30
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Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease	29
Cover Image	29
Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammation	27
Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma	27
Structural Immunology of SARS‐CoV‐2	27
Perivascular stromal cells: Directors of tissue immune niches	27
Irritable bowel syndrome: When food is a pain in the gut	26
Factor D	26
Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy*	26
Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis	25
Development and organization of omental milky spots	25
Host immune responses in the central nervous system during fungal infections	25
Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic health	25

Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease	25
Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system	25
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Cell type‐specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases	24
Understanding inhibitory receptor function in neutrophils through the lens of CLEC12A	24
Transcriptional and epigenetic regulation in thymic epithelial cells*	23
Issue Information	23
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	23
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	23
Stability and change in epigenetic regulation of immune cells	23
Cover Image	23
Cover Image	23
No time to die: Epigenetic regulation of natural killer cell survival	23
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	23
Many Achilles’ heels of B and T cell tolerance	23
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	22
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	22
Innate Immunity and Asthma Exacerbations: Insights From Human Models	22
Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	22
The fibroblast: An emerging key player in thymic T cell selection	22
Issue Information	21
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	21
Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	21
Issue Information	21
Low‐molecular weight inhibitors of the alternative complement pathway	21
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Neutrophils in aging and aging‐related pathologies	21
The nervous system during COVID‐19: Caught in the crossfire	20
Fibroblast heterogeneity and tertiary lymphoid tissues in the kidney	20
The impact of neuroinflammation on neuronal integrity	19
Regnase‐1–related endoribonucleases in health and immunological diseases	19
The impact of the human gut microbiome on the treatment of autoimmune disease	19
Epigenetic regulation of inflammation by CxxC domain‐containing proteins*	19
The gene regulatory network controlling plasma cell function	19
Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: Current understanding and future directions	18
Visualization and functional characterization of lymphoid organ fibroblasts*	18
Imaging leukocyte migration through afferent lymphatics*	18
Epigenetic gene regulation in plasma cells	18
The evolving landscape of immune‐related adverse events that follow immune checkpoint immunotherapy in cancer patients	18
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Innate Immune Receptors as Dynamic Modulators of Extrafollicular Autoimmune B Cell Response	17
Signals that control MAIT cell function in healthy and inflamed human tissues	17
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Established and emerging roles for mitochondria in neutrophils	17
Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo	17
Real‐time imaging of inflammation and its resolution: It’s apparent because it’s transparent*	17
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	17
Imaging the immune system redux	17
Innate Immune Sensors in Health and Disease	17
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death	17
Microbes and the fate of neutrophils	17
Issue Information	17
Life‐threatening antibodies: The discovery of anaphylaxis	16
Chemo‐ and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen*	16
Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches	16
Regulation of murine B lymphopoiesis by stromal cells	16
Correction to “The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids”	16
Micro but mighty—Micronutrients in the epigenetic regulation of adaptive immune responses*	15
Balanced regulation of ROS production and inflammasome activation in preventing early development of colorectal cancer	15
Introductory article for Immunological Reviews, Vol 310	15
IgE versus IgG and IgA: Differential roles of allergen‐specific antibodies in sensitization, tolerization, and treatment of allergies	15
HLA‐E: Immune Receptor Functional Mechanisms Revealed by Structural Studies	15
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Antibodies against endogenous retroviruses	15
Small matters: Introduction to extracellular vesicles	15
Immunoregulation by antibody secreting cells in inflammation, infection, and cancer	15
Regulation of immune responses to food by commensal microbes	15
The emergence of the calvarial hematopoietic niche in health and disease	15
Single‐cell advances in stromal‐leukocyte interactions in cancer	15
Role of B cells in immune‐related adverse events following checkpoint blockade	15
Copper homeostasis and cuproptosis in cancer immunity and therapy	15
CD4 T cells and toxicity from immune checkpoint blockade	14
Severe combined immunodeficiency diagnosis and genetic defects	14
Role of hormones in the pregnancy and sex‐specific outcomes to infections with respiratory viruses*	14
The role of dysregulated PI3Kdelta signaling in human autoimmunity*	14
Tissue‐Resident Th2 Cells in Type 2 Immunity and Allergic Diseases	14
What sequencing technologies can teach us about innate immunity*	14
Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis	13
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My story of sex, gender, and women's health in a pandemic*	13
Lessons Learned From Clinical Trials of Immunotherapeutics for COVID‐19	13
A Brief Molecular History of Vγ9Vδ2 TCR‐Mediated Phosphoantigen Sensing	13
Issue Information	13
Molecular determinants of immunogenic cell death elicited by radiation therapy	12
Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation	12
Living in LALA land? Forty years of attenuating Fc effector functions	12
Physiology and pathology of the C3 amplification cycle: A retrospective	12
Low‐density granulocytes in systemic autoimmunity and autoinflammation	12
Intersection of the microbiome and immune metabolism in lupus	12
Spatial determinates of effector and memory CD8+ T cell fates*	12
Whence and wherefore IgE?	12
LAG Time in the Era of Immunotherapy—New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene‐3	11
Issue Information	11
The susceptibility of the kidney to alternative pathway activation—A hypothesis	11
Role of inhibitory B cell co‐receptors in B cell self‐tolerance to non‐protein antigens*	11
Regulation of CD8 T‐cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid	11
Emerging Concepts in Cytokine Regulation of Airway Remodeling in Asthma	11
Issue Information	11
Established and Emerging Roles of DEAD/H‐Box Helicases in Regulating Infection and Immunity	11
Stress/cell death pathways, neuroinflammation, and neuropathic pain	11
Eras of designer Tregs: Harnessing synthetic biology for immune suppression	10
Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells	10
Current knowledge on the early stages of human neutropoiesis	10
The resolution of phagosomes	10
Transforming mutations in the development of pathogenic B cell clones and autoantibodies*	10
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Neutrophil modulation of behavior and cognition in health and disease: The unexplored role of an innate immune cell	10
Enhancing Fc‐mediated effector functions of monoclonal antibodies: The example of HexaBodies	10
Coengineering specificity, safety, and function into T cells for cancer immunotherapy	10
Epigenetics and CD8+ T cell memory*	10
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Stellabody: A novel hexamer‐promoting mutation for improved IgG potency	10
How RNA modifications regulate the antiviral response	10
NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance*	10
Moving beyond velocity: Opportunities and challenges to quantify immune cell behavior*	10
At the crux of maternal immune activation: Viruses, microglia, microbes, and IL‐17A	10
Age‐related macular degeneration: A disease of extracellular complement amplification	10
Issue Information	10
Local complement synthesis—A process with near and far consequences for ischemia reperfusion injury and transplantation	10
Neutrophil‐T cell crosstalk and the control of the host inflammatory response	9
Unique aspects of IFN‐γ/STAT1 signaling in neurons	9
All roads lead to IgA: Mapping the many pathways of IgA induction in the gut	9
Location, Location, Location: Spatial Immune‐Stroma Crosstalk Drives Pathogenesis in Asthma	9
FOXP3 deficiency, from the mechanisms of the disease to curative strategies	9
Cancer immunity by tissue‐resident type 1 innate lymphoid cells and killer innate‐like T cells	9
Early life imprinting of intestinal immune tolerance and tissue homeostasis	9
C3‐dependent effector functions of complement	9
Functional neutrophil disorders: Chronic granulomatous disease and beyond	9
Correction to “The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities”	9
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Maternal IgE Influence on Fetal and Infant Health	9
Engineered exosomes for studies in tumor immunology	9
Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection*	9
Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop	9
Heterogeneity in antiviral B cell responses: Lessons from the movies*	9
Coordinated Regulation of Extrafollicular B Cell Responses by IL‐12 and IFNγ	9
Apoptotic cell clearance components in inflammatory arthritis	8
Advances and challenges in studying the tissue‐resident T cell compartment in the human female reproductive tract	8
Pyroptosis in glioma: Current management and future application	8
Maternal‐driven immune education in offspring	8
Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways	8
Regulation of airway immunity by epithelial miRNAs	8
The multifaceted life of macrophages in white adipose tissue: Immune shift couples with metabolic switch	8
Using IMGT unique numbering for IG allotypes and Fc‐engineered variants of effector properties and half‐life of therapeutic antibodies	8
The complement alternative pathway in health and disease—activation or amplification?	8
The leukotriene B4 receptors BLT1 and BLT2 as potential therapeutic targets	8
Get me out of here: Sphingosine 1‐phosphate signaling and T cell exit from tissues during an immune response	8
Fantastic IgA plasma cells and where to find them	8
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Gene therapy for adenosine deaminase severe combined immune deficiency—An unexpected journey of four decades	8
The Factor H protein family: The switchers of the complement alternative pathway	8
The Cystic Fibrosis Transmembrane Conductance Receptor Brakes Allergic Airway Inflammation	8
Decoding immunogenic cell death from a dendritic cell perspective	7
The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms	7
Transcriptional and hormonal control of adipose Treg heterogeneity and function	7
Primary and secondary defects of the thymus	7
Epigenetic regulation of natural killer cell memory*	7
Type I interferon and cancer	7
Issue Information	7
Issue Information	7
Fibroblasts as confederates of the immune system	7
Small particles with large impact: Insights into the unresolved roles of innate immunity in extracellular vesicle‐mediated cardiovascular calcification	7
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Information flow in the spatiotemporal organization of immune responses*	7
Fat‐associated lymphoid clusters: Supporting visceral adipose tissue B cell function in immunity and metabolism	7
A newborn's perspective on immune responses to food	7
Targeting ferroptosis in gastric cancer: Strategies and opportunities	7
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The special unfolded protein response in plasma cells	7
Using immunogenic cell death to improve anticancer efficacy of immune checkpoint inhibitors: From basic science to clinical application	6
Issue Information	6
Molecular mechanisms of emerging inflammasome complexes and their activation and signaling in inflammation and pyroptosis	6
Epigenetic control of microglial immune responses	6
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