OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Aspects of Medicine is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
The role of free fatty acid receptors activation in pancreatic disorders	279
Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis	230
Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling	173
Corticosteroid resistance in asthma: Cellular and molecular mechanisms	163
DNA melting analysis	163
Delineating the contribution of ageing and physical activity to changes in mitochondrial characteristics across the lifespan	118
Editorial Board	108
Single-cell and spatial transcriptomics: Bridging current technologies with long-read sequencing	102
CD33 isoforms in microglia and Alzheimer's disease: Friend and foe	100
Role of autophagy in muscle disease	90
Perspectives for the application of neurogenetic research in programming Neurorehabilitation	89
Data structuring may prevent ambiguity and improve personalized medical prognosis	84
Renal insufficiency and chronic kidney disease – Promotor or consequence of pathological post-translational modifications	77
Interactions between pathological and functional amyloid: A match made in Heaven or Hell?	72
Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics	69
Autophagy signaling mediated by non-coding RNAs: Impact on breast cancer progression and treatment	64
Antiviral therapeutics directed against RNA dependent RNA polymerases from positive-sense viruses	62
Bioactives and human health	61
Rodent genetically modified models of glaucoma	60
Glucose-derived posttranslational modification in cardiovascular disease	58
Revisiting the bioavailability of flavan-3-ols in humans: A systematic review and comprehensive data analysis	55
The thermodynamic hypothesis of protein aggregation	45
Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies	44
Editorial Board	42
Decoding driver and phenotypic genes in cancer: Unveiling the essence behind the phenomenon	42

Molecular mechanisms of oxidative stress in asthma	41
Emerging technologies in personalized medicine	41
Invasive fungal infections: An expanding and evolving threat	40
Cellular and molecular mechanisms of allergic asthma	39
Computational methods in glaucoma research: Current status and future outlook	39
Strategies to deliver RNA by nanoparticles for therapeutic potential	39
An updated systematic review about various effects of microplastics on cancer: A pharmacological and in-silico based analysis	38
RNA interference (RNAi)-based therapeutics for treatment of rare neurologic diseases	37
Kinetic mechanisms for O2 binding to myoglobins and hemoglobins	37
Mitophagy: A key regulator of radiotherapy resistance in the tumor immune microenvironment	37
The recent blooming of therapeutic aptamers	36
Editorial Board	35
NRF2-mediated regulation of lipid pathways in viral infection	34
Editorial Board	34
Metabolic reprogramming shapes post-translational modification in macrophages	34
Antifungal prophylaxis and pre-emptive therapy: When and how?	33
Editorial Board	31
Molecular allergology approach to allergic asthma	31
Diet and exercise in frailty and sarcopenia. Molecular aspects	30
The enzymatic function of the honorary enzyme: S-nitrosylation of hemoglobin in physiology and medicine	30
Testicular immunity	30
Molecular mechanism involved in sarcopenia and frailty, diagnosis and therapy	30
Extracellular vesicles as personalized medicine	29
From hemoglobin allostery to hemoglobin-based oxygen carriers	29
Role of hemoglobin structural-functional relationships in oxygen transport	29
Irreversible post-translational modifications – Emerging cardiovascular risk factors	29
Understanding the role of endocrine disrupting chemicals in testicular germ cell cancer: Insights into molecular mechanisms	29
Frailty and biological age. Which best describes our aging and longevity?	28
Association between glaucoma susceptibility with combined defects in mitochondrial oxidative phosphorylation and fatty acid beta oxidation	28
Muscle aging and sarcopenia: The pathology, etiology, and most promising therapeutic targets	28
Implications of obesity-mediated cellular dysfunction and adipocytokine signaling pathways in the pathogenesis of osteoarthritis	28
Nicotinic receptors: From protein allostery to computational neuropharmacology	27
Hemoglobin allostery and pharmacology	27
Systems to model the personalized aspects of microbiome health and gut dysbiosis	27
Protein and RNA chaperones	26
Caspase mechanisms in the regulation of inflammation	26
The folding and misfolding of multidomain proteins	26
The endogenous exposome of the pregnant mother: Placental extracellular vesicles and their effect on the maternal system	26
Are we getting closer to a successful neoantigen cancer vaccine?	26
Pathological implication of protein post-translational modifications in cancer	25
Virus-like particles of retroviral origin in protein aggregation and neurodegenerative diseases	25
Autophagy in liver diseases: A review	25
When to suspect and how properly early detect and treat patients with endemic mycoses	25
Molecular aspects of exposome and metabolic diseases	24
Phenotypic screening models for rapid diagnosis of genetic variants and discovery of personalized therapeutics	24
Avenues for post-translational protein modification prevention and therapy	24
Frustration in physiology and molecular medicine	24
Modern methods of molecular diagnostics	23
Cardiovascular impact of emerging and Re-emerging Viruses: Pathophysiological mechanisms, diagnosis, and management with a pediatric focus	23
Adiponectin: its role in diabetic and pancreatic cancer	23

Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota	23
Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects	23
Ubiquitin proteasome system and glaucoma: A survey of genetics and molecular biology studies supporting a link with pathogenic and therapeutic relevance	23
Nanoformulations for dismantling fungal biofilms: The latest arsenals of antifungal therapy	22
Hemoglobin: Multiple molecular interactions and multiple functions. An example of energy optimization and global molecular organization	22
Cancer vaccines: Target antigens, vaccine platforms and preclinical models	22
Biochemical genesis of enzymatic and non-enzymatic post-translational modifications	21
Circulating tumor cells as liquid biopsy markers in cancer patients	21
Non-canonical functions of autophagy proteins in immunity and infection	21
Vaccination against Helicobacter pylori – An approach for cancer prevention?	20
Delivery of therapeutic agents and cells to pancreatic islets: Towards a new era in the treatment of diabetes	20
Insights into Women's health: Exploring the vaginal microbiome, quorum sensing dynamics, and therapeutic potential of quorum sensing quenchers	20
Diabetes and male fertility disorders	20
Controlled release nanoplatforms for three commonly used chemotherapeutics	19
Current and emerging sequencing-based tools for precision cancer medicine	19
Editorial Board	19
Molecular aspects of optic nerve autophagy in glaucoma	19
Organ Fibrosis: Emerging diagnostic and therapeutic strategies	19
The functional role of the hemoglobin-water interface	18
Molecular targets and approaches to restore autophagy and lysosomal capacity in neurodegenerative disorders	18
Hepatitis C virus chronicity and oncogenic potential: Vaccine development progress	17
Emerging diagnostic and therapeutic challenges for skin fibrosis in systemic sclerosis	17
Diagnostic and therapeutic potential of protease inhibition	17
Editorial Board	17
Health and nutrition beyond essential nutrients: The evolution of the bioactives concept for human health	17
Advances in understanding glaucoma pathogenesis: A multifaceted molecular approach for clinician scientists	16
Editorial Board	16
Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies	16
The role of the microbiota in glaucoma	16
Siglecs in health and disease	15
Altitude acclimatization, hemoglobin-oxygen affinity, and circulatory oxygen transport in hypoxia	15
The bone-muscle unit: from mechanical coupling to soluble factors-mediated signaling	15
Genetic rodent models of glaucoma in representing disease phenotype and insights into the pathogenesis	14
The uniqueness of on-demand male contraception	14
Impact of Siglecs on autoimmune diseases	14
Editorial Board	14
Molecular aspects of asthma	14
Vaccines for breast cancer prevention: Are we there yet?	14
Editorial Board	13
A pipeline for the development and analysis of extracellular vesicle-based transcriptomic biomarkers in molecular diagnostics	13
Frontiers in sarcopenia: Advancements in diagnostics, molecular mechanisms, and therapeutic strategies	13
Have safety and efficacy assessments of bioactives come of age?	13
Recent advances in intestinal fibrosis	13
In vitro high-content tissue models to address precision medicine challenges	13
Editorial Board	12
Disentangling the nutrition-microbiota liaison in inflammatory bowel disease	12
Editorial Board	12
Beyond target cell death – Granzyme serine proteases in health and disease	12
Editorial Board	12
Respiratory emerging viruses and drug resistance in lung cancer: challenges and new perspectives in treatment	12
Therapeutic strategies for glaucoma and optic neuropathies	11
Liver fibrosis in NAFLD/NASH: from pathophysiology towards diagnostic and therapeutic strategies	11
Revealing macropinocytosis using nanoparticles	11
Molecular determinants of peaceful coexistence versus invasiveness of non-Typhoidal Salmonella: Implications in long-term side-effects	11
Kidney fibrosis: Emerging diagnostic and therapeutic strategies	10
Identification and characterization of post-translational modifications: Clinical implications	10
Editorial on proteases in health and disease	10
Editorial Board	10
Signalling pathways and cell death mechanisms in glaucoma: Insights into the molecular pathophysiology	10
Physiological and pathological aspects of epididymal sperm maturation	10