OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Aspects of Medicine is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Editorial Board	247
Delineating the contribution of ageing and physical activity to changes in mitochondrial characteristics across the lifespan	204
Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis	192
The role of free fatty acid receptors activation in pancreatic disorders	178
The double-edged sword: How SARS-CoV-2 might fuel lung cancer: Investigating the potential oncogenic mechanisms of the novel coronavirus in lung carcinogenesis	150
Single-cell and spatial transcriptomics: Bridging current technologies with long-read sequencing	116
Emerging and Re-emerging viruses as triggers of human endogenous retrovirus activation: Implications for aging and age-related pathologies	105
DNA melting analysis	100
Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling	96
Corticosteroid resistance in asthma: Cellular and molecular mechanisms	85
Renal insufficiency and chronic kidney disease – Promotor or consequence of pathological post-translational modifications	79
Perspectives for the application of neurogenetic research in programming Neurorehabilitation	76
Data structuring may prevent ambiguity and improve personalized medical prognosis	76
CD33 isoforms in microglia and Alzheimer's disease: Friend and foe	71
Interactions between pathological and functional amyloid: A match made in Heaven or Hell?	70
Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics	69
The crosstalk of neutrophil extracellular trap-inflammasome and their roles in disease progression	63
Bioactives and human health	58
Autophagy signaling mediated by non-coding RNAs: Impact on breast cancer progression and treatment	54
Viral pathogens in bone- and bone-marrow derived malignancies: Friends or foes?	48
Rodent genetically modified models of glaucoma	47
The bidirectional link between diabetes and pancreatic cancer: A diagnostic aid, risk factor, and potential target for future therapy	46
Glucose-derived posttranslational modification in cardiovascular disease	45
Revisiting the bioavailability of flavan-3-ols in humans: A systematic review and comprehensive data analysis	43
The thermodynamic hypothesis of protein aggregation	43

Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies	43
Editorial Board	42
Cross-talk between cancer and diabetes: Exploring shared molecular pathways in cellular metabolism and signaling	41
Decoding driver and phenotypic genes in cancer: Unveiling the essence behind the phenomenon	41
Molecular mechanisms of oxidative stress in asthma	40
Emerging technologies in personalized medicine	40
Influence of microbiota composition on the pathogenesis of type 2 diabetes: Physiological aspects	38
Strategies to deliver RNA by nanoparticles for therapeutic potential	38
Invasive fungal infections: An expanding and evolving threat	38
Computational methods in glaucoma research: Current status and future outlook	36
An updated systematic review about various effects of microplastics on cancer: A pharmacological and in-silico based analysis	35
Cellular and molecular mechanisms of allergic asthma	35
Neuroteratogenic mechanisms of Zika virus (ZIKV) infection: Insights into fetal brain development disruption and congenital Zika syndrome: A systematic review	34
Viruses in gastrointestinal cancers: Molecular pathogenesis, oncogenic mechanisms, and translational perspectives	34
Kinetic mechanisms for O2 binding to myoglobins and hemoglobins	33
The recent blooming of therapeutic aptamers	33
Multidimensional review of viral infectious ocular diseases: Post-Pandemic epidemiology and future directions for control	33
RNA interference (RNAi)-based therapeutics for treatment of rare neurologic diseases	33
Editorial Board	32
Mitophagy: A key regulator of radiotherapy resistance in the tumor immune microenvironment	32
Editorial Board	32
Editorial Board	32
Metabolic reprogramming shapes post-translational modification in macrophages	31
Irreversible post-translational modifications – Emerging cardiovascular risk factors	30
Antifungal prophylaxis and pre-emptive therapy: When and how?	30
The ocular immune system and Flaviviruses: A crossroad between defense and disease	30
Molecular allergology approach to allergic asthma	30
The enzymatic function of the honorary enzyme: S-nitrosylation of hemoglobin in physiology and medicine	30
NRF2-mediated regulation of lipid pathways in viral infection	30
Molecular mechanism involved in sarcopenia and frailty, diagnosis and therapy	29
Testicular immunity	28
Role of hemoglobin structural-functional relationships in oxygen transport	28
Diet and exercise in frailty and sarcopenia. Molecular aspects	28
Extracellular vesicles as personalized medicine	27
Corrigendum to: “Unveiling the P2X7 receptor: Exploring its mechanisms, pathogenic role in ocular diseases, and emerging therapeutic potential” [Mol. Aspect. Med. 105 (2025) 101389 https://doi.org/10.	27
Research advancements on sumoylation in gastrointestinal cancers	27
Frailty and biological age. Which best describes our aging and longevity?	27
Association between glaucoma susceptibility with combined defects in mitochondrial oxidative phosphorylation and fatty acid beta oxidation	26
Muscle aging and sarcopenia: The pathology, etiology, and most promising therapeutic targets	26
Are we getting closer to a successful neoantigen cancer vaccine?	24
Implications of obesity-mediated cellular dysfunction and adipocytokine signaling pathways in the pathogenesis of osteoarthritis	24
Understanding the role of endocrine disrupting chemicals in testicular germ cell cancer: Insights into molecular mechanisms	24
Hemoglobin allostery and pharmacology	24
From hemoglobin allostery to hemoglobin-based oxygen carriers	24
Protein and RNA chaperones	23
Nicotinic receptors: From protein allostery to computational neuropharmacology	23
The folding and misfolding of multidomain proteins	23
Post-translational modifications: Bridging viral infections and inflammatory bowel disease	23
Systems to model the personalized aspects of microbiome health and gut dysbiosis	23
The endogenous exposome of the pregnant mother: Placental extracellular vesicles and their effect on the maternal system	22

Caspase mechanisms in the regulation of inflammation	22
Pathological implication of protein post-translational modifications in cancer	22
Molecular aspects of exposome and metabolic diseases	21
Ubiquitin proteasome system and glaucoma: A survey of genetics and molecular biology studies supporting a link with pathogenic and therapeutic relevance	21
Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota	21
Virus-like particles of retroviral origin in protein aggregation and neurodegenerative diseases	21
Frustration in physiology and molecular medicine	21
Phenotypic screening models for rapid diagnosis of genetic variants and discovery of personalized therapeutics	20
Modern methods of molecular diagnostics	20
Cardiovascular impact of emerging and Re-emerging Viruses: Pathophysiological mechanisms, diagnosis, and management with a pediatric focus	20
When to suspect and how properly early detect and treat patients with endemic mycoses	20
Avenues for post-translational protein modification prevention and therapy	20
Delivery of therapeutic agents and cells to pancreatic islets: Towards a new era in the treatment of diabetes	19
Adiponectin: its role in diabetic and pancreatic cancer	19
Hemoglobin: Multiple molecular interactions and multiple functions. An example of energy optimization and global molecular organization	19
Nanoformulations for dismantling fungal biofilms: The latest arsenals of antifungal therapy	19
Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects	18
Cancer vaccines: Target antigens, vaccine platforms and preclinical models	18
The multifunctionality of the caspase family of proteases: A new perspective beyond cell death	18
Biochemical genesis of enzymatic and non-enzymatic post-translational modifications	17
Organ Fibrosis: Emerging diagnostic and therapeutic strategies	17
Molecular aspects of optic nerve autophagy in glaucoma	17
Circulating tumor cells as liquid biopsy markers in cancer patients	17
Editorial Board	17
Vaccination against Helicobacter pylori – An approach for cancer prevention?	16
The functional role of the hemoglobin-water interface	16
Diabetes and male fertility disorders	16
Current and emerging sequencing-based tools for precision cancer medicine	16
Controlled release nanoplatforms for three commonly used chemotherapeutics	15
Insights into Women's health: Exploring the vaginal microbiome, quorum sensing dynamics, and therapeutic potential of quorum sensing quenchers	15
Health and nutrition beyond essential nutrients: The evolution of the bioactives concept for human health	14
Emerging diagnostic and therapeutic challenges for skin fibrosis in systemic sclerosis	14
Advances in understanding glaucoma pathogenesis: A multifaceted molecular approach for clinician scientists	14
Hepatitis C virus chronicity and oncogenic potential: Vaccine development progress	14
Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies	14
Editorial Board	14
Altitude acclimatization, hemoglobin-oxygen affinity, and circulatory oxygen transport in hypoxia	13
The bone-muscle unit: from mechanical coupling to soluble factors-mediated signaling	13
Editorial Board	13
Diagnostic and therapeutic potential of protease inhibition	13
Siglecs in health and disease	13
The role of the microbiota in glaucoma	13
Editorial Board	12
Editorial Board	12
Molecular aspects of asthma	12
In vitro high-content tissue models to address precision medicine challenges	11
Genetic rodent models of glaucoma in representing disease phenotype and insights into the pathogenesis	11
Vaccines for breast cancer prevention: Are we there yet?	10
Disentangling the nutrition-microbiota liaison in inflammatory bowel disease	10
Frontiers in sarcopenia: Advancements in diagnostics, molecular mechanisms, and therapeutic strategies	10
Pharmacological reprogramming of plitidepsin as a SARS-CoV-2 inhibitor	10
The uniqueness of on-demand male contraception	10
Impact of Siglecs on autoimmune diseases	10
Recent advances in intestinal fibrosis	10
Have safety and efficacy assessments of bioactives come of age?	10