OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Aspects of Medicine is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
The NLRP3 inflammasome: Mechanism of action, role in disease and therapies	191
Iron in infection and immunity	180
An overview of the non-canonical inflammasome	156
Autophagy in liver diseases: A review	136
NK cells and ILCs in tumor immunotherapy	128
Circulating miRNA analysis for cancer diagnostics and therapy	108
The Atlas of Inflammation Resolution (AIR)	106
Basics and principles of cellular and systemic iron homeostasis	106
Targets, pitfalls and reference materials for liquid biopsy tests in cancer diagnostics	99
Molecular mechanisms of oxidative stress in asthma	90
Iron: The cancer connection	85
NLRP12 in innate immunity and inflammation	70
Cellular and molecular mechanisms of allergic asthma	70
Immunometabolic control of trained immunity	70
Oral iron supplementation in iron-deficient women: How much and how often?	62
Haptoglobin: From hemoglobin scavenging to human health	58
Circulating tumor cell as the functional aspect of liquid biopsy to understand the metastatic cascade in solid cancer	56
The NAIP/NLRC4 inflammasome in infection and pathology	51
The role of O-glycosylation in human disease	51
Targeting O-GlcNAcylation to develop novel therapeutics	51
Neuronal autophagy and mitophagy in Parkinson's disease	49
Immunobiology and structural biology of AIM2 inflammasome	49
Emerging isothermal amplification technologies for microRNA biosensing: Applications to liquid biopsies	48
Epithelial keratins: Biology and implications as diagnostic markers for liquid biopsies	48
NLRP6 inflammasome	48

Pathobiology of Japanese encephalitis virus infection	47
Pathological implication of protein post-translational modifications in cancer	44
Intravenous iron supplementation therapy	42
Polysialylation and disease	40
Ageing – Oxidative stress, PTMs and disease	38
Identification and characterization of post-translational modifications: Clinical implications	34
The changing landscape of iron deficiency	31
N-glycans as functional effectors of genetic and epigenetic disease risk	31
Lipid metabolism in colon cancer: Role of Liver X Receptor (LXR) and Stearoyl-CoA Desaturase 1 (SCD1)	31
Macroautophagy and aging: The impact of cellular recycling on health and longevity	30
Cathepsin S (CTSS) activity in health and disease - A treasure trove of untapped clinical potential	29
Dysregulation of host cell calcium signaling during viral infections: Emerging paradigm with high clinical relevance	29
Biological mechanisms and therapeutic relevance of the gasdermin family	28
Genetic iron overload disorders	28
Nuclear receptors in the kidney during health and disease	28
True significance of N-acetylglucosaminyltransferases GnT-III, V and α1,6 fucosyltransferase in epithelial-mesenchymal transition and cancer	27
The roles of iron and HFE genotype in neurological diseases	26
Revealing macropinocytosis using nanoparticles	26
Role of autophagy in muscle disease	25
To protect or adversely affect? The dichotomous role of the NLRP1 inflammasome in human disease	25
Iron overload and its impact on outcome of patients with hematological diseases	25
PPARδ and its ligand erucic acid may act anti-tumoral, neuroprotective, and myelin protective in neuroblastoma, glioblastoma, and Parkinson's disease	24
Mitochondria orchestrate macrophage effector functions in atherosclerosis	24
Structural and functional diversity of neutrophil glycosylation in innate immunity and related disorders	24
Circulating cell-free tumor DNA analysis in pediatric cancers	23
Iron at the host-microbe interface	23
Moments in autophagy and disease: Past and present	22
The need for precision nutrition, genetic variation and resolution in Covid-19 patients	22
Siglec receptors as new immune checkpoints in cancer	22
Diseases related to Notch glycosylation	22
Integrating circulating miRNA analysis in the clinical management of lung cancer: Present or future?	22
Molecular and structural facets of c-di-GMP signalling associated with biofilm formation in Pseudomonas aeruginosa	21
Extracellular vesicles as personalized medicine	21
The human inflammasomes	21
Nuclear receptors: Key regulators of somatic cell functions in the ovulatory process	21
Unlocking the bacterial membrane as a therapeutic target for next-generation antimicrobial amphiphiles	20
New insights into the role of autophagy in retinal and eye diseases	20
Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota	20
Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies	19
Altitude acclimatization, hemoglobin-oxygen affinity, and circulatory oxygen transport in hypoxia	19
Thalassemias: from gene to therapy	19
Fetoplacental vasculature as a model to study human cardiovascular endocrine disruption	19
Role of hemoglobin structural-functional relationships in oxygen transport	18
The dual function of ILC2: From host protection to pathogenic players in type 2 asthma	17
Immunometabolic control of hematopoiesis	17
The endogenous exposome of the pregnant mother: Placental extracellular vesicles and their effect on the maternal system	17
Corticosteroid resistance in asthma: Cellular and molecular mechanisms	17
Viral proteases as therapeutic targets	17
The peroxidatic activities of Myoglobin and Hemoglobin, their pathological consequences and possible medical interventions	16
Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics	16

Cathepsin V: Molecular characteristics and significance in health and disease	15
Regulation of iron homeostasis: Lessons from mouse models	15
CD33 isoforms in microglia and Alzheimer's disease: Friend and foe	15
From hemoglobin allostery to hemoglobin-based oxygen carriers	15
Nuclear receptors, the aryl hydrocarbon receptor, and macrophage function	15
Iron in health and disease	14
Functional consequences of lead and mercury exposomes in the heart	14
Neutrophils at the crossroads of acute viral infections and severity	14
Estrogen Receptor on the move: Cistromic plasticity and its implications in breast cancer	13
Smoking for two- effects of tobacco consumption on placenta	13
Metabolomics in asthma: A platform for discovery	13
Nanodelivery of STING agonists against cancer and infectious diseases	13
Biochemical genesis of enzymatic and non-enzymatic post-translational modifications	13
From bench side to clinic: Potential and challenges of RNA vaccines and therapeutics in infectious diseases	13
Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases	12
Discovery, classification, evolution and diversity of Siglecs	12
Neuroglobin, clues to function and mechanism	12
Chaperone-mediated autophagy and disease: Implications for cancer and neurodegeneration	12
Revisiting the bioavailability of flavan-3-ols in humans: A systematic review and comprehensive data analysis	12
Exploiting pilus-mediated bacteria-host interactions for health benefits	12
Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming	12
The influence of the dietary exposome on oxidative stress in pregnancy complications	12
Asthma COPD overlap: Insights into cellular and molecular mechanisms	12
Neuroprotection in glaucoma: Mechanisms beyond intraocular pressure lowering	12
ILC in chronic inflammation, cancer and targeting with biologicals	11
Nicotinic receptors: From protein allostery to computational neuropharmacology	11
Recent advances, status, and opportunities of magneto-electric nanocarriers for biomedical applications	11
Circadian rhythms in the tissue-specificity from metabolism to immunity: insights from omics studies	11
The placental exposome, placental epigenetic adaptations and lifelong cardio-metabolic health	11
Exposome and foetoplacental vascular dysfunction in gestational diabetes mellitus	11
Human colonic catabolism of dietary flavan-3-ol bioactives	11
Programming of weight and obesity across the lifecourse by the maternal metabolic exposome: A systematic review	11
Controlled release nanoplatforms for three commonly used chemotherapeutics	11
Kinetic mechanisms for O2 binding to myoglobins and hemoglobins	10
Caspase mechanisms in the regulation of inflammation	10
Metabolic regulation of T lymphocyte motility and migration	10
New perspectives on PPAR, VDR and FXRα as new actors in testicular pathophysiology	10
Cysteine cathepsins: A long and winding road towards clinics	10
Iron deficiency and supplementation in heart failure and chronic kidney disease	10
Liquid biopsy analysis in cancer diagnostics	10
Impact of hemoglobin biophysical studies on molecular pathogenesis and drug therapy for sickle cell disease	10
Impact of Siglecs on autoimmune diseases	10
Hemoglobin allostery and pharmacology	10
Proteostasis in aging-associated ocular disease	10
Immunometabolism of regulatory T cells in cancer	9
Molecular allergology approach to allergic asthma	9
Metabolic adaptations of cells at the vascular-immune interface during atherosclerosis	9
The enzymatic function of the honorary enzyme: S-nitrosylation of hemoglobin in physiology and medicine	9
Innate lymphoid cells (ILC) in SARS-CoV-2 infection	9
Nanoparticle-aided glycovariant assays to bridge biomarker performance and ctDNA results	9
Hemoglobin: Multiple molecular interactions and multiple functions. An example of energy optimization and global molecular organization	9
Chapter 5 – “Parkinson's disease – A role of non-enzymatic posttranslational modifications in disease onset and progression?”	8
Delivery of therapeutic agents and cells to pancreatic islets: Towards a new era in the treatment of diabetes	8
Anthocyanin actions at the gastrointestinal tract: Relevance to their health benefits	8
Beyond target cell death – Granzyme serine proteases in health and disease	8
Molecular targets and approaches to restore autophagy and lysosomal capacity in neurodegenerative disorders	8
Galectins in allergic inflammatory diseases	7
Cell-free DNA in blood as a noninvasive insight into the sarcoma genome	7
Siglecs in allergy and asthma	7
Extracellular vesicles in the glioblastoma microenvironment: A diagnostic and therapeutic perspective	7
Non-canonical functions of autophagy proteins in immunity and infection	7
Diagnostic and therapeutic potential of protease inhibition	7
The evolving regulatory landscape in regenerative medicine	7
NK cell and ILC heterogeneity in colorectal cancer. New perspectives from high dimensional data	7
Phenotypic screening models for rapid diagnosis of genetic variants and discovery of personalized therapeutics	7
Protein synthesis in Mycobacterium tuberculosis as a potential target for therapeutic interventions	7
Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis	7