OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Aspects of Medicine is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Editorial Board	269
Delineating the contribution of ageing and physical activity to changes in mitochondrial characteristics across the lifespan	220
The role of free fatty acid receptors activation in pancreatic disorders	160
Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis	160
Corticosteroid resistance in asthma: Cellular and molecular mechanisms	152
Single-cell and spatial transcriptomics: Bridging current technologies with long-read sequencing	106
Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling	102
DNA melting analysis	98
Renal insufficiency and chronic kidney disease – Promotor or consequence of pathological post-translational modifications	97
Role of autophagy in muscle disease	89
CD33 isoforms in microglia and Alzheimer's disease: Friend and foe	80
Perspectives for the application of neurogenetic research in programming Neurorehabilitation	78
Data structuring may prevent ambiguity and improve personalized medical prognosis	73
Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics	68
Interactions between pathological and functional amyloid: A match made in Heaven or Hell?	67
The thermodynamic hypothesis of protein aggregation	61
Bioactives and human health	60
Rodent genetically modified models of glaucoma	58
Antiviral therapeutics directed against RNA dependent RNA polymerases from positive-sense viruses	57
Autophagy signaling mediated by non-coding RNAs: Impact on breast cancer progression and treatment	56
Glucose-derived posttranslational modification in cardiovascular disease	54
Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies	43
Editorial Board	42
Revisiting the bioavailability of flavan-3-ols in humans: A systematic review and comprehensive data analysis	42
Decoding driver and phenotypic genes in cancer: Unveiling the essence behind the phenomenon	41

Molecular mechanisms of oxidative stress in asthma	40
Emerging technologies in personalized medicine	40
Computational methods in glaucoma research: Current status and future outlook	39
Strategies to deliver RNA by nanoparticles for therapeutic potential	38
Invasive fungal infections: An expanding and evolving threat	37
Kinetic mechanisms for O2 binding to myoglobins and hemoglobins	37
Cellular and molecular mechanisms of allergic asthma	37
An updated systematic review about various effects of microplastics on cancer: A pharmacological and in-silico based analysis	35
The recent blooming of therapeutic aptamers	35
Editorial Board	34
RNA interference (RNAi)-based therapeutics for treatment of rare neurologic diseases	34
Molecular allergology approach to allergic asthma	33
Editorial Board	33
Editorial Board	32
Antifungal prophylaxis and pre-emptive therapy: When and how?	31
Metabolic reprogramming shapes post-translational modification in macrophages	30
NRF2-mediated regulation of lipid pathways in viral infection	30
The enzymatic function of the honorary enzyme: S-nitrosylation of hemoglobin in physiology and medicine	29
Diet and exercise in frailty and sarcopenia. Molecular aspects	29
Molecular mechanism involved in sarcopenia and frailty, diagnosis and therapy	29
Irreversible post-translational modifications – Emerging cardiovascular risk factors	29
Extracellular vesicles as personalized medicine	28
Role of hemoglobin structural-functional relationships in oxygen transport	28
Testicular immunity	28
Muscle aging and sarcopenia: The pathology, etiology, and most promising therapeutic targets	27
Understanding the role of endocrine disrupting chemicals in testicular germ cell cancer: Insights into molecular mechanisms	27
Association between glaucoma susceptibility with combined defects in mitochondrial oxidative phosphorylation and fatty acid beta oxidation	27
Frailty and biological age. Which best describes our aging and longevity?	27
From hemoglobin allostery to hemoglobin-based oxygen carriers	27
Implications of obesity-mediated cellular dysfunction and adipocytokine signaling pathways in the pathogenesis of osteoarthritis	27
Systems to model the personalized aspects of microbiome health and gut dysbiosis	26
Hemoglobin allostery and pharmacology	26
Are we getting closer to a successful neoantigen cancer vaccine?	26
Nicotinic receptors: From protein allostery to computational neuropharmacology	26
The endogenous exposome of the pregnant mother: Placental extracellular vesicles and their effect on the maternal system	26
The folding and misfolding of multidomain proteins	25
Pathological implication of protein post-translational modifications in cancer	25
Protein and RNA chaperones	25
Caspase mechanisms in the regulation of inflammation	25
When to suspect and how properly early detect and treat patients with endemic mycoses	24
Autophagy in liver diseases: A review	24
Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota	23
Molecular aspects of exposome and metabolic diseases	23
Cardiovascular impact of emerging and Re-emerging Viruses: Pathophysiological mechanisms, diagnosis, and management with a pediatric focus	22
Virus-like particles of retroviral origin in protein aggregation and neurodegenerative diseases	22
Phenotypic screening models for rapid diagnosis of genetic variants and discovery of personalized therapeutics	22
Ubiquitin proteasome system and glaucoma: A survey of genetics and molecular biology studies supporting a link with pathogenic and therapeutic relevance	22
Non-canonical functions of autophagy proteins in immunity and infection	21
Avenues for post-translational protein modification prevention and therapy	21
Biochemical genesis of enzymatic and non-enzymatic post-translational modifications	21

Modern methods of molecular diagnostics	21
Frustration in physiology and molecular medicine	21
Nanoformulations for dismantling fungal biofilms: The latest arsenals of antifungal therapy	21
Adiponectin: its role in diabetic and pancreatic cancer	21
Hemoglobin: Multiple molecular interactions and multiple functions. An example of energy optimization and global molecular organization	21
Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects	20
Delivery of therapeutic agents and cells to pancreatic islets: Towards a new era in the treatment of diabetes	20
Cancer vaccines: Target antigens, vaccine platforms and preclinical models	20
Current and emerging sequencing-based tools for precision cancer medicine	19
Editorial Board	19
The functional role of the hemoglobin-water interface	19
Circulating tumor cells as liquid biopsy markers in cancer patients	19
Organ Fibrosis: Emerging diagnostic and therapeutic strategies	19
Insights into Women's health: Exploring the vaginal microbiome, quorum sensing dynamics, and therapeutic potential of quorum sensing quenchers	18
Emerging diagnostic and therapeutic challenges for skin fibrosis in systemic sclerosis	18
Vaccination against Helicobacter pylori – An approach for cancer prevention?	18
Molecular targets and approaches to restore autophagy and lysosomal capacity in neurodegenerative disorders	18
Hepatitis C virus chronicity and oncogenic potential: Vaccine development progress	17
Molecular aspects of optic nerve autophagy in glaucoma	17
Diabetes and male fertility disorders	17
Controlled release nanoplatforms for three commonly used chemotherapeutics	17
Editorial Board	16
Health and nutrition beyond essential nutrients: The evolution of the bioactives concept for human health	16
Advances in understanding glaucoma pathogenesis: A multifaceted molecular approach for clinician scientists	16
Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies	16
Editorial Board	15
Diagnostic and therapeutic potential of protease inhibition	15
Editorial Board	14
Siglecs in health and disease	14
Genetic rodent models of glaucoma in representing disease phenotype and insights into the pathogenesis	14
Altitude acclimatization, hemoglobin-oxygen affinity, and circulatory oxygen transport in hypoxia	14
The role of the microbiota in glaucoma	14
Molecular aspects of asthma	14
The bone-muscle unit: from mechanical coupling to soluble factors-mediated signaling	14
Editorial Board	13
Vaccines for breast cancer prevention: Are we there yet?	13
In vitro high-content tissue models to address precision medicine challenges	12
Frontiers in sarcopenia: Advancements in diagnostics, molecular mechanisms, and therapeutic strategies	12
Have safety and efficacy assessments of bioactives come of age?	12
The uniqueness of on-demand male contraception	12
Impact of Siglecs on autoimmune diseases	12
Beyond target cell death – Granzyme serine proteases in health and disease	12
Recent advances in intestinal fibrosis	12
Disentangling the nutrition-microbiota liaison in inflammatory bowel disease	12
Editorial Board	11
Editorial Board	11
Editorial Board	11
A pipeline for the development and analysis of extracellular vesicle-based transcriptomic biomarkers in molecular diagnostics	11
Respiratory emerging viruses and drug resistance in lung cancer: challenges and new perspectives in treatment	10
Revealing macropinocytosis using nanoparticles	10
Molecular determinants of peaceful coexistence versus invasiveness of non-Typhoidal Salmonella: Implications in long-term side-effects	10
Therapeutic strategies for glaucoma and optic neuropathies	10
Liver fibrosis in NAFLD/NASH: from pathophysiology towards diagnostic and therapeutic strategies	9
Kidney fibrosis: Emerging diagnostic and therapeutic strategies	9
Editorial Board	9
Identification and characterization of post-translational modifications: Clinical implications	9
Signalling pathways and cell death mechanisms in glaucoma: Insights into the molecular pathophysiology	9
Physiological and pathological aspects of epididymal sperm maturation	9
Current understanding of genetics and epigenetics in pseudoexfoliation syndrome and glaucoma	9
Editorial on proteases in health and disease	9