OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Aspects of Medicine is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)

Article	Citations
The NLRP3 inflammasome: Mechanism of action, role in disease and therapies	228
Iron in infection and immunity	198
An overview of the non-canonical inflammasome	165
Autophagy in liver diseases: A review	151
NK cells and ILCs in tumor immunotherapy	138
The Atlas of Inflammation Resolution (AIR)	120
Basics and principles of cellular and systemic iron homeostasis	113
Molecular mechanisms of oxidative stress in asthma	109
Iron: The cancer connection	93
Cellular and molecular mechanisms of allergic asthma	85
Immunometabolic control of trained immunity	75
NLRP12 in innate immunity and inflammation	75
Oral iron supplementation in iron-deficient women: How much and how often?	67
The role of O-glycosylation in human disease	60
Targeting O-GlcNAcylation to develop novel therapeutics	59
Pathological implication of protein post-translational modifications in cancer	58
Pathobiology of Japanese encephalitis virus infection	55
The NAIP/NLRC4 inflammasome in infection and pathology	55
Immunobiology and structural biology of AIM2 inflammasome	54
NLRP6 inflammasome	52
Neuronal autophagy and mitophagy in Parkinson's disease	52
Ageing – Oxidative stress, PTMs and disease	48
Intravenous iron supplementation therapy	45
Polysialylation and disease	44
Cathepsin S (CTSS) activity in health and disease - A treasure trove of untapped clinical potential	42

Identification and characterization of post-translational modifications: Clinical implications	40
Lipid metabolism in colon cancer: Role of Liver X Receptor (LXR) and Stearoyl-CoA Desaturase 1 (SCD1)	38
Macroautophagy and aging: The impact of cellular recycling on health and longevity	34
N-glycans as functional effectors of genetic and epigenetic disease risk	33
Revealing macropinocytosis using nanoparticles	33
The changing landscape of iron deficiency	32
Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming	31
Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies	31
Siglec receptors as new immune checkpoints in cancer	31
Dysregulation of host cell calcium signaling during viral infections: Emerging paradigm with high clinical relevance	31
Structural and functional diversity of neutrophil glycosylation in innate immunity and related disorders	30
Genetic iron overload disorders	30
Extracellular vesicles as personalized medicine	29
Biological mechanisms and therapeutic relevance of the gasdermin family	29
The human inflammasomes	29
Nuclear receptors in the kidney during health and disease	28
The roles of iron and HFE genotype in neurological diseases	27
Role of autophagy in muscle disease	27
Iron overload and its impact on outcome of patients with hematological diseases	27
To protect or adversely affect? The dichotomous role of the NLRP1 inflammasome in human disease	27
True significance of N-acetylglucosaminyltransferases GnT-III, V and α1,6 fucosyltransferase in epithelial-mesenchymal transition and cancer	27
PPARδ and its ligand erucic acid may act anti-tumoral, neuroprotective, and myelin protective in neuroblastoma, glioblastoma, and Parkinson's disease	26
Mitochondria orchestrate macrophage effector functions in atherosclerosis	26
Diseases related to Notch glycosylation	26
Iron at the host-microbe interface	26
Neuroprotection in glaucoma: Mechanisms beyond intraocular pressure lowering	25
Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota	25
New insights into the role of autophagy in retinal and eye diseases	23
Unlocking the bacterial membrane as a therapeutic target for next-generation antimicrobial amphiphiles	23
Fetoplacental vasculature as a model to study human cardiovascular endocrine disruption	23
Moments in autophagy and disease: Past and present	23
Thalassemias: from gene to therapy	22
The need for precision nutrition, genetic variation and resolution in Covid-19 patients	22
CD33 isoforms in microglia and Alzheimer's disease: Friend and foe	21
Altitude acclimatization, hemoglobin-oxygen affinity, and circulatory oxygen transport in hypoxia	21
Nuclear receptors: Key regulators of somatic cell functions in the ovulatory process	21
Molecular and structural facets of c-di-GMP signalling associated with biofilm formation in Pseudomonas aeruginosa	21
Corticosteroid resistance in asthma: Cellular and molecular mechanisms	20
Viral proteases as therapeutic targets	19
Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics	19
The peroxidatic activities of Myoglobin and Hemoglobin, their pathological consequences and possible medical interventions	19
Cathepsin V: Molecular characteristics and significance in health and disease	19
From hemoglobin allostery to hemoglobin-based oxygen carriers	19
Role of hemoglobin structural-functional relationships in oxygen transport	19
Neutrophils at the crossroads of acute viral infections and severity	18
The dual function of ILC2: From host protection to pathogenic players in type 2 asthma	17
Nuclear receptors, the aryl hydrocarbon receptor, and macrophage function	17
The endogenous exposome of the pregnant mother: Placental extracellular vesicles and their effect on the maternal system	17
Immunometabolic control of hematopoiesis	17
Metabolomics in asthma: A platform for discovery	16

Functional consequences of lead and mercury exposomes in the heart	16
Smoking for two- effects of tobacco consumption on placenta	16
Regulation of iron homeostasis: Lessons from mouse models	16
Chaperone-mediated autophagy and disease: Implications for cancer and neurodegeneration	15
Proteostasis in aging-associated ocular disease	15
Estrogen Receptor on the move: Cistromic plasticity and its implications in breast cancer	15
Iron in health and disease	15
Extracellular vesicles in the glioblastoma microenvironment: A diagnostic and therapeutic perspective	15
Anthocyanin actions at the gastrointestinal tract: Relevance to their health benefits	15
Neuroglobin, clues to function and mechanism	15
Cysteine cathepsins: A long and winding road towards clinics	14
Exposome and foetoplacental vascular dysfunction in gestational diabetes mellitus	14
The influence of the dietary exposome on oxidative stress in pregnancy complications	14
Discovery, classification, evolution and diversity of Siglecs	14
Nanodelivery of STING agonists against cancer and infectious diseases	14
From bench side to clinic: Potential and challenges of RNA vaccines and therapeutics in infectious diseases	14
Human colonic catabolism of dietary flavan-3-ol bioactives	14
Nicotinic receptors: From protein allostery to computational neuropharmacology	13
Recent advances, status, and opportunities of magneto-electric nanocarriers for biomedical applications	13
Biochemical genesis of enzymatic and non-enzymatic post-translational modifications	13
The placental exposome, placental epigenetic adaptations and lifelong cardio-metabolic health	13
Revisiting the bioavailability of flavan-3-ols in humans: A systematic review and comprehensive data analysis	13
Circadian rhythms in the tissue-specificity from metabolism to immunity: insights from omics studies	13
Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases	13
Controlled release nanoplatforms for three commonly used chemotherapeutics	13
Hemoglobin: Multiple molecular interactions and multiple functions. An example of energy optimization and global molecular organization	13
Kinetic mechanisms for O2 binding to myoglobins and hemoglobins	12
Hemoglobin allostery and pharmacology	12
ILC in chronic inflammation, cancer and targeting with biologicals	12
Programming of weight and obesity across the lifecourse by the maternal metabolic exposome: A systematic review	12
Asthma COPD overlap: Insights into cellular and molecular mechanisms	12
Iron deficiency and supplementation in heart failure and chronic kidney disease	12
Exploiting pilus-mediated bacteria-host interactions for health benefits	12
RNA interference (RNAi)-based therapeutics for treatment of rare neurologic diseases	11
Diagnostic and therapeutic potential of protease inhibition	11
Impact of hemoglobin biophysical studies on molecular pathogenesis and drug therapy for sickle cell disease	11
New perspectives on PPAR, VDR and FXRα as new actors in testicular pathophysiology	11
Caspase mechanisms in the regulation of inflammation	11
Liver fibrosis in NAFLD/NASH: from pathophysiology towards diagnostic and therapeutic strategies	11
Beyond target cell death – Granzyme serine proteases in health and disease	10
Measuring the intake of dietary bioactives: Pitfalls and how to avoid them	10
The enzymatic function of the honorary enzyme: S-nitrosylation of hemoglobin in physiology and medicine	10
Metabolic adaptations of cells at the vascular-immune interface during atherosclerosis	10
The changing epidemiology of fungal infections	10
Immunometabolism of regulatory T cells in cancer	10
Phenotypic screening models for rapid diagnosis of genetic variants and discovery of personalized therapeutics	10
Impact of Siglecs on autoimmune diseases	10
Metabolic regulation of T lymphocyte motility and migration	10
Molecular allergology approach to allergic asthma	10
Cardiac Fibrosis in heart failure: Focus on non-invasive diagnosis and emerging therapeutic strategies	9
Innate lymphoid cells (ILC) in SARS-CoV-2 infection	9
Siglecs in allergy and asthma	9
Delivery of therapeutic agents and cells to pancreatic islets: Towards a new era in the treatment of diabetes	9
Chapter 5 – “Parkinson's disease – A role of non-enzymatic posttranslational modifications in disease onset and progression?”	8
Molecular targets and approaches to restore autophagy and lysosomal capacity in neurodegenerative disorders	8
Truncated (2/2) hemoglobin: Unconventional structures and functional roles in vivo and in human pathogenesis	8
The evolving regulatory landscape in regenerative medicine	8
Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies	8
Protein synthesis in Mycobacterium tuberculosis as a potential target for therapeutic interventions	8