OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Aspects of Medicine is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Editorial Board	267
Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis	255
Delineating the contribution of ageing and physical activity to changes in mitochondrial characteristics across the lifespan	201
Editorial Board	140
Emerging and Re-emerging viruses as triggers of human endogenous retrovirus activation: Implications for aging and age-related pathologies	134
The double-edged sword: How SARS-CoV-2 might fuel lung cancer: Investigating the potential oncogenic mechanisms of the novel coronavirus in lung carcinogenesis	118
DNA melting analysis	118
Toward molecular and pathology-confirmed completeness in advanced ovarian cancer cytoreduction: Intraoperative molecular imaging and integrated theranostic strategies	117
Single-cell and spatial transcriptomics: Bridging current technologies with long-read sequencing	116
The role of free fatty acid receptors activation in pancreatic disorders	114
Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling	112
Perspectives for the application of neurogenetic research in programming Neurorehabilitation	111
Renal insufficiency and chronic kidney disease – Promotor or consequence of pathological post-translational modifications	93
Data structuring may prevent ambiguity and improve personalized medical prognosis	75
Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics	75
Interactions between pathological and functional amyloid: A match made in Heaven or Hell?	73
Advancing precision medicine in pancreatic cancer using novel biomarkers and clinical targets	70
CD33 isoforms in microglia and Alzheimer's disease: Friend and foe	63
The crosstalk of neutrophil extracellular trap-inflammasome and their roles in disease progression	61
Beyond 100 years of vitamin E and related molecules – Milestones and open challenges	61
The thermodynamic hypothesis of protein aggregation	61
The bidirectional link between diabetes and pancreatic cancer: A diagnostic aid, risk factor, and potential target for future therapy	59
Vav3, a potential diagnostic and prognostic marker of diabetes, regulates glycolipid metabolism	57
Autophagy signaling mediated by non-coding RNAs: Impact on breast cancer progression and treatment	57
Viral pathogens in bone- and bone-marrow derived malignancies: Friends or foes?	56

Rodent genetically modified models of glaucoma	53
Glucose-derived posttranslational modification in cardiovascular disease	52
Bioactives and human health	50
Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies	48
Editorial Board	47
Revisiting the bioavailability of flavan-3-ols in humans: A systematic review and comprehensive data analysis	47
Decoding driver and phenotypic genes in cancer: Unveiling the essence behind the phenomenon	46
Emerging technologies in personalized medicine	46
Integrating immunopeptidomics with liquid biopsy for precision oncology	44
Influence of microbiota composition on the pathogenesis of type 2 diabetes: Physiological aspects	43
Cross-talk between cancer and diabetes: Exploring shared molecular pathways in cellular metabolism and signaling	43
Invasive fungal infections: An expanding and evolving threat	42
Computational methods in glaucoma research: Current status and future outlook	41
RNA interference (RNAi)-based therapeutics for treatment of rare neurologic diseases	39
Multidimensional review of viral infectious ocular diseases: Post-Pandemic epidemiology and future directions for control	38
Neuroteratogenic mechanisms of Zika virus (ZIKV) infection: Insights into fetal brain development disruption and congenital Zika syndrome: A systematic review	37
An updated systematic review about various effects of microplastics on cancer: A pharmacological and in-silico based analysis	37
Mitophagy: A key regulator of radiotherapy resistance in the tumor immune microenvironment	36
The recent blooming of therapeutic aptamers	36
Viruses in gastrointestinal cancers: Molecular pathogenesis, oncogenic mechanisms, and translational perspectives	36
Editorial Board	35
Decoding emerging viral sepsis: Molecular crosstalk, dysregulation, and precision strategies	35
The ocular immune system and Flaviviruses: A crossroad between defense and disease	34
Editorial Board	34
Editorial Board	34
Advances in sperm transcription and translation activities: From traditional views to new discoveries	33
Antifungal prophylaxis and pre-emptive therapy: When and how?	33
Metabolic reprogramming shapes post-translational modification in macrophages	32
Molecular mechanism involved in sarcopenia and frailty, diagnosis and therapy	31
NRF2-mediated regulation of lipid pathways in viral infection	31
Irreversible post-translational modifications – Emerging cardiovascular risk factors	31
Testicular immunity	30
Diet and exercise in frailty and sarcopenia. Molecular aspects	30
Corrigendum to: “Unveiling the P2X7 receptor: Exploring its mechanisms, pathogenic role in ocular diseases, and emerging therapeutic potential” [Mol. Aspect. Med. 105 (2025) 101389 https://doi.org/10.	29
The multiorgan crosstalk network of the liver-brain axis: From molecular mechanisms to emerging therapeutic targets	29
Extracellular vesicles as personalized medicine	29
Understanding the role of endocrine disrupting chemicals in testicular germ cell cancer: Insights into molecular mechanisms	28
Serine metabolism in the central nervous system: advances and challenges on a conditionally essential amino acid	28
Association between glaucoma susceptibility with combined defects in mitochondrial oxidative phosphorylation and fatty acid beta oxidation	28
Unravelling the mystery of hypoxia-induced miRNAs in breast cancer: A molecular cross-talk driving tumour progression and therapy resistance	27
Research advancements on sumoylation in gastrointestinal cancers	27
Frailty and biological age. Which best describes our aging and longevity?	27
Implications of obesity-mediated cellular dysfunction and adipocytokine signaling pathways in the pathogenesis of osteoarthritis	26
Muscle aging and sarcopenia: The pathology, etiology, and most promising therapeutic targets	26
The endogenous exposome of the pregnant mother: Placental extracellular vesicles and their effect on the maternal system	25
Are we getting closer to a successful neoantigen cancer vaccine?	25
Caspase mechanisms in the regulation of inflammation	25
Systems to model the personalized aspects of microbiome health and gut dysbiosis	25
Post-translational modifications: Bridging viral infections and inflammatory bowel disease	24
Protein and RNA chaperones	24

The folding and misfolding of multidomain proteins	24
Ubiquitin proteasome system and glaucoma: A survey of genetics and molecular biology studies supporting a link with pathogenic and therapeutic relevance	23
Pathological implication of protein post-translational modifications in cancer	23
Cardiovascular impact of emerging and Re-emerging Viruses: Pathophysiological mechanisms, diagnosis, and management with a pediatric focus	22
Editorial: Honoring Dr. Angelo Azzi's legacy and expanding the horizons of Molecular Aspects of Medicine	21
Virus-like particles of retroviral origin in protein aggregation and neurodegenerative diseases	21
Avenues for post-translational protein modification prevention and therapy	21
When to suspect and how properly early detect and treat patients with endemic mycoses	21
Phenotypic screening models for rapid diagnosis of genetic variants and discovery of personalized therapeutics	21
Frustration in physiology and molecular medicine	20
Editorial Board	20
Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota	20
Molecular aspects of exposome and metabolic diseases	20
Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects	19
Modern methods of molecular diagnostics	19
The multifunctionality of the caspase family of proteases: A new perspective beyond cell death	19
Impact of type 2 diabetes on malignancies of the female reproductive system	19
Circulating tumor cells as liquid biopsy markers in cancer patients	18
Nanoformulations for dismantling fungal biofilms: The latest arsenals of antifungal therapy	18
Biochemical genesis of enzymatic and non-enzymatic post-translational modifications	18
Adiponectin: its role in diabetic and pancreatic cancer	18
Cancer vaccines: Target antigens, vaccine platforms and preclinical models	17
Insights into Women's health: Exploring the vaginal microbiome, quorum sensing dynamics, and therapeutic potential of quorum sensing quenchers	16
Molecular aspects of optic nerve autophagy in glaucoma	16
Vaccination against Helicobacter pylori – An approach for cancer prevention?	16
Diabetes and male fertility disorders	16
Organ Fibrosis: Emerging diagnostic and therapeutic strategies	16
Emerging diagnostic and therapeutic challenges for skin fibrosis in systemic sclerosis	16
Current and emerging sequencing-based tools for precision cancer medicine	16
Editorial Board	16
Editorial Board	16
Editorial Board	16
Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies	15
Advances in understanding glaucoma pathogenesis: A multifaceted molecular approach for clinician scientists	15
Health and nutrition beyond essential nutrients: The evolution of the bioactives concept for human health	15
Hepatitis C virus chronicity and oncogenic potential: Vaccine development progress	15
Editorial Board	14
The role of the microbiota in glaucoma	14
Diagnostic and therapeutic potential of protease inhibition	14
Siglecs in health and disease	14
The bone-muscle unit: from mechanical coupling to soluble factors-mediated signaling	13
Editorial Board	12
In vitro high-content tissue models to address precision medicine challenges	12
Genetic rodent models of glaucoma in representing disease phenotype and insights into the pathogenesis	12
Vaccines for breast cancer prevention: Are we there yet?	12
Pharmacological reprogramming of plitidepsin as a SARS-CoV-2 inhibitor	12
The uniqueness of on-demand male contraception	11
Decoding the dialogue: The vagus nerve at the interface of brain, body, and Tumor	10
Editorial Board	10
Impact of Siglecs on autoimmune diseases	10
Have safety and efficacy assessments of bioactives come of age?	10
Beyond target cell death – Granzyme serine proteases in health and disease	10
Recent advances in intestinal fibrosis	10
A pipeline for the development and analysis of extracellular vesicle-based transcriptomic biomarkers in molecular diagnostics	10
Frontiers in sarcopenia: Advancements in diagnostics, molecular mechanisms, and therapeutic strategies	10
Disentangling the nutrition-microbiota liaison in inflammatory bowel disease	9
Emerging viroporins, RBP dynamics, and skeletal remodeling: Targeting liquid-liquid phase separation for dual antiviral and bone-protective therapies	9
Respiratory emerging viruses and drug resistance in lung cancer: challenges and new perspectives in treatment	9
Editorial Board	9
Targeting emerging viruses with phage display-driven engineered antibodies: Bridging molecular design and clinical application	9