Seminars in Thrombosis and Hemostasis

Papers
(The median citation count of Seminars in Thrombosis and Hemostasis is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)
ArticleCitations
92
59
The Next, Next-Generation of Sequencing, Promising to Boost Research and Clinical Practice56
Thrombotic Antiphospholipid Syndrome and Direct Oral Anticoagulants: Unmet Needs and Review of the Literature51
Drug–Drug Interactions in the Treatment of Cancer-Associated Venous Thromboembolism with Direct Oral Anticoagulants43
Prevention of Venous Thromboembolism in Medical Patients with Thrombocytopenia or with Platelet Dysfunction: The Last 10 Years42
Hemostatic Manifestations of Invasive Fungal Infections: A Comprehensive Review of Pathophysiological Mechanisms in Sepsis-Induced Hemostatic Disturbances, with a Focus on the Neonatal Population39
Role of Platelets in Rheumatic Chronic Autoimmune Inflammatory Diseases37
Cancer-Associated Thrombosis: Implications toward Health-Related Quality of Life35
Fright of Long-Haul Flights: Focus on Travel-Associated Thrombosis35
Redefining Fibrinolytic Insufficiency in Sepsis-Associated DIC34
Monitoring Hemostatic Function During Extracorporeal Membrane Oxygenation with Point-of-Care Viscoelastic Assays: A Narrative Review34
Thrombosis in Antiphospholipid Syndrome: Current Perspectives and Challenges in Laboratory Testing for Antiphospholipid Antibodies34
Resonant Acoustic Rheometry to Measure Coagulation Kinetics in Hemophilia A and Healthy Plasma: A Novel Viscoelastic Method32
Testing for Lupus Anticoagulants31
Thrombin Generation Assays in Clinical Hemostasis: From Mechanistic Insights to Clinical Applications30
Lupus Anticoagulant-hypoprothrombinemia Syndrome: A Review Enriched by a New Particular Patient26
Platelet Function Testing: Update and Future Directions26
Platelet Activation and Thrombosis in COVID-1926
Application of ACR/EULAR Classification Criteria in Real Life: Thrombotic Patients Positive for Lupus Anticoagulant Only26
Gut Microbiota and Venous Thromboembolism: An Emerging Link25
Editorial Compilation—XIII24
Platelet Function: Acute versus Chronic Responses to Physical Exercise: A Review24
Anticoagulation Management of Patients with Antiphospholipid Syndrome Undergoing Cardiopulmonary Bypass in Cardiac Surgery: Challenges and Current Strategies24
The History of Rare Bleeding Disorders23
External Quality Assessment for Unfractionated Heparin Monitoring: An Update from Australasia/Asia-Pacific22
How Do Laboratories Perform von Willebrand Disease Diagnostics and Classification of von Willebrand Disease Patients? Results from External Quality Data and an International Survey22
22
Evolving Knowledge on Primary and Secondary Prevention of Venous Thromboembolism in Carriers of Hereditary Thrombophilia: A Narrative Review22
Autoantibodies in Autoimmune Coagulation Factor Deficiencies: A Review of Inhibitory and Clearance-Accelerating Mechanisms from Japanese Practice21
Anti-platelet Factor 4 Antibody-Mediated Disorders: An Updated Narrative Review21
Modulating Immune Responses: The Double-Edged Sword of Platelet CD40L20
Fifty Years of Fibrinogen Structure and Function19
Gene Therapy for Hemophilia B: Achievements, Open Issues, and Perspectives19
Toward 50 Years of Seminars in Thrombosis and Hemostasis19
Evolution of Clinical Trials in Anticoagulation for Sepsis: Bridging Past to Future19
Celebrating 50 Years of Seminars in Thrombosis and Hemostasis—Part III18
2022 Eberhard F. Mammen Award Announcements: Part I—Most Popular Articles18
Association between Severe Acute Respiratory Syndrome Coronavirus 2 Infection (Coronavirus Disease 2019) and Lupus Anticoagulant-Hypoprothrombinemia Syndrome: A Case Report and Literature Assessment18
Magnetic Resonance Screening for Cerebral Venous Sinus Thrombosis during Treatment with Pegaspargase18
Patterns of Antiphospholipid Antibody Testing and Positivity in a Real-World Laboratory over Two Decades: The Role of IgM18
Bleeding in Patients with Renal Impairment: A Current Perspective18
50 Years of Pediatric Hemostasis: Knowledge, Diagnosis, and Treatment17
Platelet Function in Patients with Disseminated Intravascular Coagulation: Potential Markers for Improving DIC Diagnosis?17
Platelet–Red Blood Cell Interactions in Thrombosis: Integrating Hemodynamic, Molecular, and Clinical Evidence–A Systematic Review16
Investigating a Signal of Acquired Hemophilia Associated with COVID-19 Vaccination: A Systematic Case Review16
Comprehensive Mendelian Randomization Analysis of Smoking and Its Effects on Venous Thromboembolism16
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Bernard–Soulier Syndrome: A Review of Epidemiology, Molecular Pathology, Clinical Features, Laboratory Diagnosis, and Therapeutic Management15
Emicizumab in Type 3 von Willebrand Disease: Report of a Case with an Alloantibody and Literature Review14
Seminars in Thrombosis and Hemostasis: 2024 Impact Factor, Most Highly Cited Papers, and Other Journal Metrics14
External Quality Assessment Data for Investigation of von Willebrand Disease: Focus on Relative Utility of Contemporary Functional von Willebrand Factor Assays. The United Kingdom National External Qu14
Mendelian Randomization Provides No Evidence for the Bidirectional Relationship between Type 2 Diabetes and Venous Thromboembolism in East Asians and African Americans14
In Search of the Perfect Thrombosis and Bleeding-Associated Cancer Scale14
Reply to the Comment: Research Design Concerns in a TriNetX Analysis of Venous Thromboembolism in Pediatric Cystic Fibrosis Patients14
Laboratory Testing for the Evaluation of Phenotypic Activated Protein C Resistance14
Use of Present-on-Admission Indicators to Improve Accuracy of Pulmonary Embolism Identification from Electronic Health Record Data14
From Ink Pens to Computers: A Personal Look Back at Landmark Changes during 5 Decades as a Clinical Laboratory Scientist in U.S. Hemostasis Laboratories14
Strength of Anticoagulation in Moderate to Severe COVID-19 Illness: In Medio Stat Virtus?14
2025 Eberhard F. Mammen Award Announcements–Part II: Young Investigator Awards14
Automation in Platelet Function Testing: Current Challenges and Future Directions14
Machine Learning Prediction of Stress-Induced D-dimer Reactivity in Male Physicians with and without Burnout14
Heparin-Like Anticoagulant: First Case Described in a Metastatic Biliopancreatic Cancer13
A Brief History of Hemostasis and Thrombosis at the Mayo Clinic13
Optimizing Venous Stenting: Consensus Recommendations for Enhanced Management of Lower Extremity Deep Vein Thrombosis13
The Erythrocyte–ROS Axis in Thrombosis and Hemostasis13
Colchicine as a Modulator of Platelet Function: A Systematic Review13
Clinical, Laboratory, and Molecular Aspects of Factor V Deficiency13
Gene Therapy in Hemophilia A: Achievements, Challenges, and Perspectives13
13
Physical Activity in People with Hemophilia13
Neutrophil Extracellular Traps: At the Interface of Thrombosis and Comorbidities13
Comparative Study of Venous Thromboembolic Prophylaxis Strategies for Patients with Ischemic Stroke: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials13
Venous Thromboembolism in Children: The Rivaroxaban Experience12
Dosing Intensity of Anticoagulants for the Prevention and Treatment of Venous Thromboembolism and the Prevention of Stroke in Atrial Fibrillation: Why is There a Difference?12
Editorial Compilation XIV12
International Council for Standardization in Haematology Guidance for New Lot Verification of Coagulation Reagents, Calibrators, and Controls12
COVID-19 Vaccine-Associated Immune Thrombosis and Thrombocytopenia (VITT): Diagnostic Discrepancies and Global Implications12
Lipopolysaccharide and Coagulation Factor XII: Biophysics of Contact Activation in Infection12
Red Blood Cell Biomechanics and Cancer-Associated Thrombosis12
Comparison of Platelet Function Tests for Long-Term Cardiovascular Events after Percutaneous Coronary Interventions12
11
COVID-19 and Anticoagulant Use: Did the Pandemic Push DOACs Ahead of Warfarin?11
Acquired Hemostasis Disorders11
Editorial Compilation—Part XVIII11
Decoding Clot Waveform Analysis: Toward Better Understanding and Harmonization11
Pleiotropic Effects of Heparin and its Monitoring in the Clinical Practice11
Impact of Hematocrit on Coagulation Measured by Rotational Thromboelastometry in Healthy Subjects and Patients with Polycythemia11
Pulmonary Embolism-Related Mortality in Femur Fracture Patients: A Recent Retrospective Epidemiological Analysis11
Bleeding Scoring Systems in Neonates: A Systematic Review11
Risk Factors for Left Ventricular Thrombus Formation in Patients with Dilated Cardiomyopathy11
Past, Present, and Future Perspectives of Plasminogen Activator Inhibitor 1 (PAI-1)11
Clinical Features of Antiphospholipid Syndrome with Intracardiac Mass11
Mortality from Pulmonary Embolism in Patients with Post-Coronavirus Disease Syndrome11
A Historical Perspective on the Reversal of Anticoagulants11
Emicizumab in Acquired Hemophilia A: A Real-World Case Series with Patient-Level Outcome Analysis11
100 Years of von Willebrand Disease: The Journey to Contemporary Diagnostic Pathways—An Illustrative Case-Based Narrative Review10
The Applicability of Thromboelastography in Acute Ischemic Stroke: A Literature Review10
Activated Partial Thromboplastin Time and Prothrombin Time Mixing Studies: Current State of the Art10
Evaluating Diagnostic Algorithms for Heparin-Induced Thrombocytopenia using Two Combined Automated Rapid Immunoassays10
D-Dimer Reporting and Harmonization: Analysis of College of American Pathologists D-Dimer Proficiency Testing Program10
Precision Medicine in Rare Bleeding Disorders10
Hematohidrosis in 15th Century Renaissance Art and a Review of Modern Literature10
Platelet Physiology10
9
Do we Have the Gut to Beat Thrombosis?9
A Perspective on How Fibrinaloid Microclots and Platelet Pathology May be Applied in Clinical Investigations9
Hemostasis Testing in the Emergency Department: A Narrative Review9
Use of Plasma-Derived FVII Concentrate in Surgical Patients with Factor VII Deficiency: A Case Series9
Von Willebrand Disease Type 2A: An Update9
Molecular Mimicry between hPF4 and SARS-CoV-2 Spike Protein: Response to Comment9
The Role of Platelets in Atherosclerosis: A Historical Review9
Cancer-Associated Thrombosis and Beyond: Biomarkers, Treatments, and Cancer-Hemostasis Interactions9
Safety and Efficacy of Therapeutic Anticoagulation with Subcutaneous Unfractionated Heparin in Patients with Renal Failure9
Transitioning of Patients from Direct-Acting Oral Anticoagulant to Heparin: Impact on Laboratory Testing9
National Early Warning Score-2 for Identification of Patients with Intermediate-High-Risk Pulmonary Embolism9
Heterogeneity Among Plasma-Derived von Willebrand Factor Concentrates: Implications for Comparative Effectiveness Analyses9
Emerging Use of Viscoelastography in Thrombosis and Hemostasis: A Challenge to Conventional Coagulation Tests? Part I: The Use of Thromboelastography and Thromboelastometry in the Assessment of Hemost9
Thrombin Generation Assays: What are the Current Clinical Applications?9
The Pathophysiological Role of Platelet-Derived Extracellular Vesicles9
9
NETosis in Acute Thrombotic Disorders9
Current Diagnosis of von Willebrand Disease in Italy: 3 Years Following the Release of the International Guidelines9
Non-factor Therapies for Hemophilia: Achievements and Perspectives9
Evolution of Antiphospholipid Syndrome8
Internal Quality Control in Hemostasis Assays8
Increased HDL-C Values and Mortality: Revolutionizing a Historical Paradigm?8
Advances in the Management of Coagulopathy in Trauma: The Role of Viscoelastic Hemostatic Assays across All Phases of Trauma Care8
Crucial Stepping Stones in Platelet History8
Laboratory Testing for Fibrinogen Disorders: From Routine Investigations to Research Studies8
The More Recent History of Hemophilia Treatment8
Laboratory Testing for ADAMTS13 for Thrombotic Thrombocytopenia Purpura and Beyond8
Why Does Rivaroxaban Not Work in Severe Mitral Stenosis?8
It Is Proposed That Cardiovascular Functions are Regulated by the Status of Ecto-phosphoproteins Orchestrated by Platelets8
Discordant High Activated Partial Thromboplastin Time Relative to Anti-Xa Values in Hospitalized Patients is an Independent Risk Factor for Increased 30-day Mortality8
2022 Eberhard F. Mammen Award Announcements: Part II—Young Investigator Awards8
PFA-100 System: A New Method for Assessment of Platelet Dysfunction8
Current Understandings on Biological Characteristics of Thrombolytics in Acute Ischemic Stroke8
7
Hemostatic Aspects of Interactions Between Anticancer Drugs and Oral Anticoagulants in Patients with Cancer-Associated Venous Thromboembolism7
Dysregulation of the FVIII–VWF Axis in Early-Onset Ischemic Stroke7
Nebulized Heparin in 2025: at the Interface between Promising Benefits and the Need for Further Research7
Advanced Treatment of Hemodynamically Unstable Acute Pulmonary Embolism and Clinical Follow-up7
Cellular Components Contributing to the Development of Venous Thrombosis in Patients with Pancreatic Cancer7
How Do Muscles Protect Joints in Hemophilia? Integrating Mechanical, Neural, and Endocrine Mechanisms7
D-dimers—“Normal” Levels versus Elevated Levels Due to a Range of Conditions, Including “D-dimeritis,” Inflammation, Thromboembolism, Disseminated Intravascular Coagulation, and COVID-197
One Hundred Years of Congenital Fibrinogen Disorders7
Risk Factors for Major Adverse Cardiovascular Events and Major Adverse Limb Events after Venous Thromboembolism: A Large Prospective Cohort Study7
Clinical, Laboratory, and Molecular Aspects of Factor VII Deficiency7
Antiplatelet Therapy in Coronary Artery Disease: Now and Then7
Factor Replacement Treatment for Hemophilia A: Achievements and Perspectives7
Next-Generation Sequencing and Emerging Technologies*7
New Seminars in Thrombosis and Hemostasis (STH) 2021 Impact Factor, Most Highly Cited Papers, and Other Journal Metrics7
Limb Ischemic Necrosis Secondary to Microvascular Thrombosis: A Brief Historical Review7
Comparison of Thrombophilia Assay Results for the International Society on Thrombosis and Haemostasis Scientific and Standardization Committee Plasma Standard from Different External Quality Assessmen7
A Novel Variant on the Thrombospondin Type-1 Repeat 2 Domain of ADAMTS13 in a Parturient with Suspected Hereditary Thrombotic Thrombocytopenic Purpura and Unusually High ADAMTS13 Activity6
Deep Vein Thrombosis in Adults with HIV: A Systematic Review and Meta-analysis of Prevalence and Risk Factors6
Platelets in Neonatal Sepsis: Beyond Clotting, From Silent Players to Immune Orchestrators6
Nonsevere Hemophilia: The Need for a Renewed Focus and Improved Outcomes6
Unlocking the Potential of MicroRNA Expression: Biomarkers for Platelet Reactivity and Coronary Artery Disease6
Congenital Bleeding Disorders and COVID-19—A Systematic Literature Review6
Factor VIII and Factor IX Activity Measurements for Hemophilia Diagnosis and Related Treatments6
Hereditary Angioedema: The Clinical Picture of Excessive Contact Activation6
Viscoelastic Management of Coagulopathy during the Perioperative Period of Liver Transplantation6
Variable Performance of Lupus Anticoagulant Testing: The Australasian/Asia-Pacific Experience6
Plasma Kallikrein as a Forgotten Clotting Factor6
Risk Factors for Antiphospholipid Antibodies and Antiphospholipid Syndrome6
The Pitfalls of Global Hemostasis Assays in Myeloproliferative Neoplasms and Future Challenges6
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Clinical, Laboratory Aspects and Management of Factor X Deficiency6
Application of Activators Ecarin and Factor Xa in Thrombelastography for Measurement of Anticoagulant Effect of Direct Oral Anticoagulants Using TEG 50006
Thrombosis Risk Assessment in Myeloproliferative Neoplasm—Is There a Role for Viscoelastic Testing?6
2023 Eberhard F. Mammen Award Announcements: Part II–Young Investigator Awards6
Platelet Function in Acute Kidney Injury: A Systematic Review and a Cohort Study6
Association of the Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, Lymphocyte-to-Monocyte Ratio, and Monocyte-to-High-Density Lipoprotein Cholesterol Ratio with In Situ Vena Cava Thrombo6
Laboratory Evaluation of Antithrombin, Protein C, and Protein S6
The Novel C-Terminal Cystine Knot (Exon 52) VWF p.Cys2771Phe Variant Produces a Type 2A von Willebrand Factor Multimer Pattern with an Apparent Dimerization Defect6
Against Therapeutic Anticoagulation in Critically Ill COVID-19 Patients6
Rebalanced hemostasis, bleeding and thrombosis in liver disease: a comprehensive review of pathophysiology, management and future perspectives6
Antiphospholipid Syndrome in Patients with Venous Thromboembolism5
Impact of Viral Infections on the Hemostatic System5
Recurrent Bleeding after Cervical Surgery with Quebec Platelet Disorder: Case Report and Literature Review5
What Role Does Microthrombosis Play in Long COVID?5
Platelets: Physiology and Biochemistry5
Viscoelastic Testing in the Clinical Management of Subarachnoid Hemorrhage and Intracerebral Hemorrhage5
Thrombosis in Pregnant Women with Hematological Malignancies: A Case-Based Review5
100 Years of von Willebrand Disease: Celebrating a Significant Milestone in von Willebrand Disease Diagnostics and Management5
Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook5
Dosing, Monitoring, Blood Product Utilization, and Thromboembolic Complications of Four-Factor Prothrombin Complex Concentrate as Part of an Institutional Protocol in Pediatric Cardiac Surgery: A Retr5
Anticoagulation with Intravenous Direct Thrombin Inhibitors in Pediatric Extracorporeal Membrane Oxygenation: A Systematic Review of the Literature5
Monitoring Hemostatic Function during Cardiac Surgery with Point-of-Care Viscoelastic Assays: A Narrative Review5
Has “D-Dimeritis” Worsened during the Coronavirus Disease 2019 Pandemic?5
Isolated Low von Willebrand Factor Collagen-Binding Activity in Patients with a Positive Bleeding Phenotype: Diagnostic Implications for Von Willebrand Disease5
Epidemiology and Predisposing Factors of Post-COVID Venous Thrombosis: A Concise Review5
Venous Thromboembolism after Hospital Discharge: Temporal Trends in Baseline Characteristics, Prevention, Treatment, and 90-day Outcomes5
Detecting Oxygenator Thrombosis in ECMO: A Review of Current Techniques and an Exploration of Future Directions5
A Critical Reappraisal of the Bleeding Time5
Human Genetic Variation in F3 and Its Impact on Tissue Factor–Dependent Disease5
Platelets in Vascular Calcification: A Comprehensive Review of Platelet-Derived Extracellular Vesicles, Protein Interactions, Platelet Function Indices, and their Impact on Cellular Crosstalk5
Red Blood Cells and Tranexamic Acid in the Inhibition of Fibrinolysis5
Secondary Anticoagulation Use in Patients < 21 Years Old following Primary Anticoagulant Treatment for Provoked Venous Thromboembolism: Findings from the Kids-DOTT Trial5
Classification Criteria for the Antiphospholipid Syndrome: Not the Same as Diagnostic Criteria for Antiphospholipid Syndrome5
Pathogen Reduction Technologies and Their Impact on Metabolic and Functional Properties of Treated Platelet Concentrates: A Systematic Review5
Assessment of Hemostatic Profile in Neonates with Intrauterine Growth Restriction: A Systematic Review of Literature5
Is Vitamin D Deficiency Prothrombotic? A Systematic Review5
Antiphospholipid Antibodies in Pregnancy: Maternal and Neonatal Implications5
Reviewing the Rich History of Fibrin Clot Research with a Focus on Clinical Relevance5
Hemostasis, Thrombosis, and Vascular Biology in Psychiatric Disorders4
Platelet Contributions to the (Pre)metastatic Tumor Microenvironment4
Red Blood Cells are Critical for Hemostasis and Thrombosis4
Diagnosis and Treatment of Autoimmune Acquired Coagulation Factor Deficiencies: An Evidence-Based Review of Japanese Practice4
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Evolution of Hemostasis Testing: A Personal Reflection Covering over 40 Years of History*4
Optimizing and Extending the Risk-Adapted Management of Acute Pulmonary Embolism beyond the Acute Phase: Progress in Pulmonary Embolism Research4
A Tragedy within a Tragedy: How the Inappropriate Request for D-dimer during the COVID-19 Pandemic Might Have Harmed So Many People4
Post COVID-19 Large Vessel Vasculopathy in a Previously Healthy Young Male4
Clinical Studies with Anticoagulants that Have Changed Clinical Practice4
Measuring Quality of Life after Venous Thromboembolism: Who, When, and How?4
Neutrophil-Mediated Effects on Hemostasis and Thrombosis: Unraveling Their Complex Interaction in Thrombotic Events4
Editorial Compilation XII4
Laser-Induced Blood Coagulation for Surgical Application: A Scoping Review4
Relative Hypercoagulopathy of the SARS-CoV-2 Beta and Delta Variants when Compared to the Less Severe Omicron Variants Is Related to TEG Parameters, the Extent of Fibrin Amyloid Microclots, and the Se4
Targeting the Contact Pathway of Coagulation for the Prevention and Management of Medical Device-Associated Thrombosis4
Prone Position and the Risk of Venous Thrombosis in COVID-19 Patients with Respiratory Failure4
From the Discovery of ADAMTS13 to Current Understanding of Its Role in Health and Disease4
Sudden Cardiac Arrest and Death in Sports: An Updated Overview of Epidemiology, Etiologies, and Prevention Strategies, with Emphasis on Inherited Cardiomyopathies4
The Evolution of Hemophilia Pharmacological Treatments and Therapeutic Targets at the Turn of the Third Millennium4
New Horizons in Fetal and Neonatal Alloimmune Thrombocytopenia4
Coronary Thrombosis with Distal Embolization in a Young Patient after Orthopaedic Surgery: An Informative Case Report4
Causal Relationships of Circulating Inflammatory Proteins and Portal Vein Thrombosis: A Mendelian Randomization Study4
Causal Associations Between Cardiovascular Risk Factors and Venous Thromboembolism4
Heparins May Not Be the Optimal Anticoagulants for Sepsis and Sepsis-Associated Disseminated Intravascular Coagulation4
Comparative Analysis of Four Risk Stratification Models to Identify Patients with Acute Pulmonary Embolism at Risk of Short-term Mortality4
Editorial Compilation—XV4
Viscoelastic Hemostatic Assays in Sepsis: From Pathophysiology to Potential Clinical Implications4
Correlation between Phenotype and Coagulation Factor Activity Level in Rare Bleeding Disorders: A Systematic Review4
4
Hemostatic and Inflammatory Biomarkers are Associated with Functional Limitations after Venous Thromboembolism: A Prospective Cohort Study4
Prophylaxis of Venous Thromboembolism in Children: A Systematic Review4
4
Pearls and Pitfalls in the Measurement of Direct Oral Anticoagulants4
Role of Viscoelastic and Conventional Coagulation Tests for Management of Blood Product Replacement in the Bleeding Patient4
The ABO Blood System and Associated Implications for Hemostasis and Thrombosis4
Risk Factors of Catheter-Related Thrombosis in Elderly Patients with Lung Cancer Based on Thromboelastography: A Retrospective, Case-Control Study4
Antiphospholipid Antibodies in Mental Disorders4
Recommendations on the use of COVID-19 Convalescent Plasma to Treat Immunocompromised Patients3
Risk of Venous Thromboembolism by Cancer Type: A Network Meta-Analysis3
Are Antiphospholipid Antibodies a Surrogate Risk Factor for Thrombosis in Sepsis?3
Patient Perspective on Disease Burden and Gene Therapy for Hemophilia A and B: The “Haemvolution for Patients” Italian Survey3
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