(The TQCC of Cell is 71. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-02-01 to 2024-02-01.)
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor14792
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein5819
Integrated analysis of multimodal single-cell data5226
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus3306
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-193294
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals2735
Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE22050
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues1749
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE21693
Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding1612
The Architecture of SARS-CoV-2 Transcriptome1596
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-191419
Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity1394
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism1304
The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity1279
Adaptive immunity to SARS-CoV-2 and COVID-191257
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract1161
Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology1104
Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells1068
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment1050
Proteomic and Metabolomic Characterization of COVID-19 Patient Sera1048
Toll-like Receptors and the Control of Immunity1021
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity1010
A Deep Learning Approach to Antibiotic Discovery878
Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera877
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes844
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2797
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant775
The Global Phosphorylation Landscape of SARS-CoV-2 Infection769
Molecular Architecture of the SARS-CoV-2 Virus736
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses718
Hallmarks of aging: An expanding universe705
Single-Cell Transcriptome Atlas of Murine Endothelial Cells691
Mechanisms and disease consequences of nonalcoholic fatty liver disease680
The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic671
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer659
G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules654
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers631
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19625
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase625
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications621
Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19619
A Genomic Perspective on the Origin and Emergence of SARS-CoV-2590
Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2578
Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum559
Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy555
Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin547
COVID-19-neutralizing antibodies predict disease severity and survival542
SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron539
Multiple early factors anticipate post-acute COVID-19 sequelae535
RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation528
Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery528
Hallmarks of response, resistance, and toxicity to immune checkpoint blockade526
Clinically Applicable AI System for Accurate Diagnosis, Quantitative Measurements, and Prognosis of COVID-19 Pneumonia Using Computed Tomography526
Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells515
Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization515
A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells507
The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas498
Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum495
Plant Immunity: Danger Perception and Signaling495
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein492
COVID-19 and the human innate immune system488
Antibody evasion by the P.1 strain of SARS-CoV-2486
Pan-Genome of Wild and Cultivated Soybeans472
Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2471
A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies461
Effects of COVID-19 on the Nervous System455
Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease454
A Thermostable mRNA Vaccine against COVID-19453
Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition452
Gut-microbiota-targeted diets modulate human immune status443
COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas440
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells438
Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies434
A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice432
Major Impacts of Widespread Structural Variation on Gene Expression and Crop Improvement in Tomato429
Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera428
A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2423
Targeting Strategies for Tissue-Specific Drug Delivery422
A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA416
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma416
SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses413
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS411
β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway410
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome409
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation406
Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front397
Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer396
Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2393
Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants392
High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue389
Emerging Pandemic Diseases: How We Got to COVID-19384
A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS383
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma377
The Science of Antibiotic Discovery376
Genome engineering for crop improvement and future agriculture373
Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment372
Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes370
Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients368
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection368
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays368
Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant366
A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors366
Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis347
Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma341
Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection340
Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex340
Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism338
Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2334
Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing332
The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease331
A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer322
Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease321
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity320
Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza319
Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage318
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors318
The basic immunology of asthma317
Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear316
The Self-Organizing Genome: Principles of Genome Architecture and Function314
Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches311
SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape311
The antigenic anatomy of SARS-CoV-2 receptor binding domain308
The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution306
Massive expansion of human gut bacteriophage diversity306
Fibroblasts: Origins, definitions, and functions in health and disease304
RNA-Mediated Feedback Control of Transcriptional Condensates302
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes296
Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron295
Molecular topography of an entire nervous system295
Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma293
TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy292
The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling290
Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses290
A Genetic Map of the Response to DNA Damage in Human Cells289
Coast-to-Coast Spread of SARS-CoV-2 during the Early Epidemic in the United States288
Bifidobacteria-mediated immune system imprinting early in life286
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing286
Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer285
Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice282
Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains278
A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model278
Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection278
Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells276
Single-Cell Transcriptomic Atlas of Primate Ovarian Aging274
Atherosclerosis: Recent developments272
CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors270
The Human and Mouse Enteric Nervous System at Single-Cell Resolution269
Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner268
Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis268
Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients267
Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction266
Tackling COVID-19 with neutralizing monoclonal antibodies266
Proteogenomic Characterization of Endometrial Carcinoma264
Integrative Proteomic Characterization of Human Lung Adenocarcinoma261
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor260
Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer257
The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway256
Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema255
Circular RNAs: Characterization, cellular roles, and applications255
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy255
Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity254
How Machine Learning Will Transform Biomedicine254
Multi-organ proteomic landscape of COVID-19 autopsies253
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis251
Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies249
Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality248
Generation of Functional Human 3D Cortico-Motor Assembloids246
Humoral and cellular immune memory to four COVID-19 vaccines239
Molecular Choreography of Acute Exercise239
The Rise of Molecular Glues239
Spatiotemporal analysis of human intestinal development at single-cell resolution238
IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression238
Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine236
Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy235
The Emerging Landscape of Immune Cell Therapies235
Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States235
Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy234
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense230
Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes229
High-coverage whole-genome sequencing of the expanded 1000 Genomes Project cohort including 602 trios228
Endometriosis: Etiology, pathobiology, and therapeutic prospects228
Hallmarks of Health227
Telomeres: history, health, and hallmarks of aging226
Adipose-tissue plasticity in health and disease226
Mitochondrial Diseases: Hope for the Future226
Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb225
Co-option of Neutrophil Fates by Tissue Environments224
SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2224
Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses224
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins223
Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination223
A Quantitative Proteome Map of the Human Body222
Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike221
Spatially organized multicellular immune hubs in human colorectal cancer220
Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output220
Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy217
Pan-genome analysis of 33 genetically diverse rice accessions reveals hidden genomic variations217
In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies214
Proteogenomic characterization of pancreatic ductal adenocarcinoma209
Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system209
Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment208
Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development208
Personalized Mapping of Drug Metabolism by the Human Gut Microbiome206
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients203
Cardioids reveal self-organizing principles of human cardiogenesis199
Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures198
Bacterial Retrons Function In Anti-Phage Defense196
Click Chemistry in Proteomic Investigations196
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer196
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis195
Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome192
A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance192
Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis189
Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans189
Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging187
Noninvasive Early Identification of Therapeutic Benefit from Immune Checkpoint Inhibition187
Metabolic modeling of single Th17 cells reveals regulators of autoimmunity181
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells179
Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer179
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19178
Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells177
An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies177
Cellular and Molecular Probing of Intact Human Organs176
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition176
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity176
Modulation of RNA Condensation by the DEAD-Box Protein eIF4A176
Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells175
Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production175
Roadmap for the Emerging Field of Cancer Neuroscience174
Maternal Fecal Microbiota Transplantation in Cesarean-Born Infants Rapidly Restores Normal Gut Microbial Development: A Proof-of-Concept Study174
Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic174
Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species174
Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules173
T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals171
Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques171
Mitocytosis, a migrasome-mediated mitochondrial quality-control process170
Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration169
Hallmarks of environmental insults169
A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection169
The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages168
SnapShot: Ferroptosis166
Hallmarks of neurodegenerative diseases166
Cone-shaped HIV-1 capsids are transported through intact nuclear pores165
Synaptic Specificity, Recognition Molecules, and Assembly of Neural Circuits164
Massively parallel assessment of human variants with base editor screens163
Revisiting astrocyte to neuron conversion with lineage tracing in vivo162
Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption161
Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression161
Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex161