Cell

Article	Citations
A sound mind in a sound body: Stress-induced glucocorticoids exacerbate gut inflammation	5957
Bound by the love for cholesterol: A transporter meets a GPCR	1672
Keiji Tanaka (1949–2024)	1184
OLAH connects fatty acid metabolism to the severity of respiratory viral disease	1093
Mesoscopic mapping of the brain: From rodents to primates	962
Learning from HBCUs: How to produce Black professionals in STEMM	935
Prying the lid open: Atomic-level insights on sialoglycan-TMPRSS2 coordination in HKU1 entry	876
RNA quality control factors nucleate Clr4/SUV39H and trigger constitutive heterochromatin assembly	841
Response to: The information theory of aging has not been tested	823
Five decades of advances in cancer research	789
Retraction notice to: Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells	764
Can H5N1 avian influenza in dairy cattle be contained in the US?	696
In vivo DNA replication dynamics unveil aging-dependent replication stress	683
CAR T therapy extends its reach to autoimmune diseases	678
Channel synapse mediates neurotransmission of airway protective chemoreflexes	665
Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation	628
Shaping pit structure in vessel walls sustains xylem hydraulics and grain yield	623
Muscle fusogens go viral for gene delivery to skeletal muscle	622
Structure-based discovery of CFTR potentiators and inhibitors	608
Global surveillance and countermeasures for ACE2-using MERS-related coronaviruses with spillover risk	602
Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome	599
EBV and MS: The evidence is growing stronger	569
Recycling of modified H2A-H2B provides short-term memory of chromatin states	559
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center	550
A metabolic balance of GLP-1 and NMDA receptors in the brain	540

Replaying germinal center evolution on a quantified affinity landscape	522
A deep learning strategy to identify cell types across species from high-density extracellular recordings	514
In vitro human cell-based models: What can they do and what are their limitations?	513
Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin	509
From periphery to center stage: 50 years of advancements in innate immunity	499
Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma	490
Deciphering breast cancer: from biology to the clinic	457
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis	443
Senescence-resistant human mesenchymal progenitor cells counter aging in primates	439
Genome instability triggers intercellular DNA transfer between human cells	438
Dynamic dimer-of-dimers architecture defines Mg2+ transport in human CNNM4	436
Structure and infection dynamics of mycobacteriophage Bxb1	433
The intrinsic cardiac nervous system is essential for cardiac function and survival	430
PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development	416
Macrophages at the interface of the co-evolving cancer ecosystem	413
Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain	408
Interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses	402
Evolution and genetic adaptation of fishes to the deep sea	401
Procr+ chondroprogenitors sense mechanical stimuli to govern articular cartilage maintenance and regeneration	400
Interferons in health and disease	392
The expanding world of neuroscience	383
Plasmodesmata act as unconventional membrane contact sites regulating intercellular molecular exchange in plants	381
De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses	381
A pan-cancer analysis of the microbiome in metastatic cancer	373
Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex	369
Choroid plexus mast cells drive tumor-associated hydrocephalus	367
Genomic architecture of autism from comprehensive whole-genome sequence annotation	365
Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution	365
Functional diversification of dietary plant small molecules by the gut microbiome	354
Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells	350
Structural basis for Cas9 off-target activity	347
Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias	342
Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic	341
A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility	335
Structures of LRP2 reveal a molecular machine for endocytosis	330
Structural specializations of the sperm tail	324
Ovarian cancer-derived IL-4 promotes immunotherapy resistance	323
Pursuing structural biology in China	322
To see is to experience: Aggression neurons light up when witnessing a fight	320
An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms	316
Propofol: Milk of Amnesia	313
The information theory of aging has not been tested	309
A mechano-resistance mechanism in skin adapts to terrestrial locomotion	308
A genetic basis for sex differences in Xp11 translocation renal cell carcinoma	303
Molecular characterization of Ebola virus glycoprotein V75A substitution in the 2018–2020 epidemic	298
A gut-retching discovery	295
Structural basis of respiratory complex adaptation to cold temperatures	294
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1	293
Multi-layered computational gene networks by engineered tristate logics	293
Structurally divergent and recurrently mutated regions of primate genomes	281

SnapShot: Condensates in plant biology	279
It took a long, long time: Ras and the race to cure cancer	277
Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy	275
How do DEI initiatives impact STEMM, and why do we still need them?	275
The developmental basis of fingerprint pattern formation and variation	273
Planetary microbiome structure and generalist-driven gene flow across disparate habitats	273
Microglia maintain structural integrity during fetal brain morphogenesis	272
Engineering RNA export for measurement and manipulation of living cells	271
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification	269
Structural basis for human Cav1.2 inhibition by multiple drugs and the neurotoxin calciseptine	268
Nuclear envelope budding enables export of large transcripts in muscle cells	266
Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity	264
The evolution of high-order genome architecture revealed from 1,000 species	262
Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration	262
Structural basis of Wnt signalosome extracellular complex assembly	262
A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions	261
Sleep is required to consolidate odor memory and remodel olfactory synapses	259
Mechanism of IFT-A polymerization into trains for ciliary transport	256
The first two blastomeres contribute unequally to the human embryo	252
Listening to the bladder field: Urine liquid biopsies reveal differential treatment responses in NMIBC	252
A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis	247
Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function	247
UniPert-G2CP bridges genetic and chemical screens from molecular representation to phenotype modeling	246
Influence of autozygosity on common disease risk across the phenotypic spectrum	244
Ancient hybridization underlies tuberization and radiation of the potato lineage	238
Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss	236
Gasdermin E couples viral pyroptosis to lethal hepatic lipid accumulation	235
Uncovering spatially resolved functional genomics with CRISPR screen sequencing	233
HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity	232
Establishing the relationship between brain cellular senescence and brain structure	230
DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs	228
Hallmarks of neurodegenerative diseases	228
Predicting competition and substrate preferences for targeted microbiome alteration	227
Gut-liver axis calibrates intestinal stem cell fitness	224
Optimizing stem cell infusion timing in the prevention of acute graft-versus-host disease	222
Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease	220
Immune checkpoint blockade provokes resident memory T cells to eliminate head and neck cancer	218
Pathogen protein modularity enables elaborate mimicry of a host phosphatase	217
Multimodal charting of molecular and functional cell states via in situ electro-sequencing	216
SnapShot: Cell size control	215
Unraveling Mendel’s final mysteries: A genomic retelling of pea genetics	214
Celebrating our origins with cell biology	214
Small-molecule hypoxia therapy in mitochondrial disease	213
ExSPECKt the unexpected: NLRP3-caspase-8-dependent cell death in RBCs	212
Small RNAs are modified with N-glycans and displayed on the surface of living cells	212
Gut microbiome ecological topology as next-generation biomarkers for cancer immunotherapy	209
Evolution of diapause in the African turquoise killifish by remodeling the ancient gene regulatory landscape	208
Spatial transcriptomics redraws the olfactory map	208
Striking a nerve: Sensory neurons orchestrate ECM remodeling and immune exclusion in TNBC	207
Engineered cell entry links receptor biology with single-cell genomics	206
The genetic history of the Southern Caucasus from the Bronze Age to the Early Middle Ages: 5,000 years of genetic continuity despite high mobility	204
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming	204
Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin	203
An Arabidopsis single-nucleus atlas decodes leaf senescence and nutrient allocation	203
Novel integrative elements and genomic plasticity in ocean ecosystems	202
Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network	202
A generative deep learning approach to de novo antibiotic design	202
Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation	201
Mining metatranscriptomes reveals a vast world of viroid-like circular RNAs	200
Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations	200
A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia	200
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs	200
Ultrafast distant wound response is essential for whole-body regeneration	199
Fine particle air pollution and lung cancer risk: Extending the long list of health risks	198
Root microbiota regulates tiller number in rice	197
Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution	197
Open-ST: High-resolution spatial transcriptomics in 3D	196
A phytoscreen identifies a garlic compound as a deterrent of mating and egg laying in Drosophila and mosquitoes	196
Tracing the origin of alveolar stem cells in lung repair and regeneration	196
PIEZO2 in somatosensory neurons controls gastrointestinal transit	195
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes	195
Induced epigenetic changes memorized across generations in mice	194
Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes	194
TGF-β signaling in health and disease	194
Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s?	193
Paul Berg and the origins of recombinant DNA	190
Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT	190
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration	190
Nothing about us without us: Sharing results with communities that provide genomic data	189
Resmetirom for treatment of MASH	188

Bringing the genetically minimal cell to life on a computer in 4D	187
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic	185
Snapshot: Choroid plexus brain barrier	185
Development of non-spatial grid-like neural codes tracks inference and intelligence	185
Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema	184
Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques	184
ER stress transforms random olfactory receptor choice into axon targeting precision	183
Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance	176
Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans	175
Small STEPs toward a big change	174
Transposable element DNA and RNA: Drivers of gene expression, evolution, and disease	173
Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin	172
Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions	171
The human proteome with direct physical access to DNA	171
Structural insights into auxin influx mediated by the Arabidopsis AUX1	171
Bispecific dendritic-T cell engager potentiates anti-tumor immunity	170
Jumbo phage killer immune system targets early infection of nucleus-forming phages	170
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway	170
Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy	169
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes	169
Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection	168
A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance	168
Arbitrium phages can manipulate each other’s lysis/lysogeny decisions	167
Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution	167
Ancient host-associated microbes obtained from mammoth remains	166
RNA structure programs endogenous ADAR for precise and efficient editing	165
Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity	164
ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion	163
Comparative landscape of genetic dependencies in human and chimpanzee stem cells	163
Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture	162
Whole-organ and whole-body 3D atlases enable cellome-wide profiling	161
Overcoming drug resistance in cancer	160
A widely distributed gene cluster compensates for uricase loss in hominids	160
Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation	157
High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients	156
Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants	155
Intrinsic heterogeneity of primary cilia revealed through spatial proteomics	154
Mechanism of DNA capture by the MukBEF SMC complex and its inhibition by a viral DNA mimic	152
A neutrophil response linked to tumor control in immunotherapy	151
A conserved family of immune effectors cleaves cellular ATP upon viral infection	151
The extracellular matrix integrates mitochondrial homeostasis	151
Differential inhibition of Morbillivirus and Henipavirus polymerases by ERDRP-0519 and structure-guided inhibitor optimization	151
A multi-tissue metabolome atlas of primate pregnancy	150
Immunotherapy-related cognitive impairment after CAR T cell therapy in mice	149
Proteome-scale movements and compartment connectivity during the eukaryotic cell cycle	149
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures	148
A general chemical principle for creating closure-stabilizing integrin inhibitors	148
Cancer biomarkers: Emerging trends and clinical implications for personalized treatment	148
Do autoantibodies shape cancer immunosurveillance?	148
Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature	148
The genetic history of Scandinavia from the Roman Iron Age to the present	148
Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate	147
Spatial proteomics in neurons at single-protein resolution	146
Systematic profiling reveals betaine as an exercise mimetic for geroprotection	145
Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors	144
Phage therapy: From biological mechanisms to future directions	144
Atlas of the aging mouse brain reveals white matter as vulnerable foci	144
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity	143
Macrophages in health and disease	143
Chromosome-level organization of the regulatory genome in the Drosophila nervous system	143
Cancer neuroscience: State of the field, emerging directions	142
Differential mosquito attraction to humans is associated with skin-derived carboxylic acid levels	141
Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primates	141
Human microglial state dynamics in Alzheimer’s disease progression	141
How to build the virtual cell with artificial intelligence: Priorities and opportunities	139
Harnessing social media to challenge scientific misinformation	139
Seven days in the life cycle of Homo sapiens	139
Before you call the midwife	138
Structural studies put phage defense mystery on the RADAR	138
Staphylococcus scratches its itch	138
A circadian rheostat drives proton electrochemical gradients to optimize cell-type-specific growth in Arabidopsis	138
Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer	137
A recipe for chaos: Extrachromosomal DNA and the hallmarks of cancer	137
Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program	137
Medication effects on the gut microbiome in allo-HCT	136
A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors	136
Hijacking ERAD for targeted degradation of transmembrane proteins	136
Cytoplasmic division cycles without the nucleus and mitotic CDK/cyclin complexes	136
Nuclear proteome reveals microtubule-associated protein regulating fate and disease	136
Expansion and CAR engineering of granulocyte-monocyte progenitors for cellular immunotherapy	135
Deep-learning-based de novo discovery and design of therapeutics that reverse disease-associated transcriptional phenotypes	135
Cervicovaginal microbiome and natural history of Chlamydia trachomatis in adolescents and young women	135
Mast cells regulate the brain-dura interface and CSF dynamics	135
Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks	134
Schwann cell-secreted PGE2 promotes sensory neuron excitability during development	134
Saturation mutagenesis-reinforced functional assays for disease-related genes	134
Transport mechanism and pharmacology of the human GlyT1	134
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration	133
STING signaling modulation by COPII cargo recognition	133
Integrative spatial analysis reveals a multi-layered organization of glioblastoma	133
A percolation phase transition controls complement protein coating of surfaces	133
Shared neural geometries for bilingual semantic representations in human hippocampal neurons	133
Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment	132
Fibroblastic reticular cells generate protective intratumoral T cell environments in lung cancer	132
Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations	132