Cell

Article	Citations
Response to: The information theory of aging has not been tested	3953
Keiji Tanaka (1949–2024)	2157
Muscle fusogens go viral for gene delivery to skeletal muscle	1220
A sound mind in a sound body: Stress-induced glucocorticoids exacerbate gut inflammation	1143
EBV and MS: The evidence is growing stronger	908
Reply to Over-celling fetal microbial exposure	905
A metabolic balance of GLP-1 and NMDA receptors in the brain	889
Shaping pit structure in vessel walls sustains xylem hydraulics and grain yield	850
Learning from HBCUs: How to produce Black professionals in STEMM	818
In vivo DNA replication dynamics unveil aging-dependent replication stress	801
Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome	798
Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma	790
Structures of LRP2 reveal a molecular machine for endocytosis	739
Structural basis for Cas9 off-target activity	731
Local hyperthermia therapy induces browning of white fat and treats obesity	705
A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility	698
Choroid plexus mast cells drive tumor-associated hydrocephalus	694
Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells	682
Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic	664
Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain	571
Senescence-resistant human mesenchymal progenitor cells counter aging in primates	568
Global surveillance and countermeasures for ACE2-using MERS-related coronaviruses with spillover risk	536
From periphery to center stage: 50 years of advancements in innate immunity	535
Channel synapse mediates neurotransmission of airway protective chemoreflexes	532
Patterning by contraction	505

Bound by the love for cholesterol: A transporter meets a GPCR	490
In vitro human cell-based models: What can they do and what are their limitations?	484
Prying the lid open: Atomic-level insights on sialoglycan-TMPRSS2 coordination in HKU1 entry	481
Five decades of advances in cancer research	477
Interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses	474
Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias	472
Procr+ chondroprogenitors sense mechanical stimuli to govern articular cartilage maintenance and regeneration	468
CAR T therapy extends its reach to autoimmune diseases	466
PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development	463
De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses	463
RNA quality control factors nucleate Clr4/SUV39H and trigger constitutive heterochromatin assembly	455
A deep learning strategy to identify cell types across species from high-density extracellular recordings	454
Interferons in health and disease	445
Recycling of modified H2A-H2B provides short-term memory of chromatin states	444
OLAH connects fatty acid metabolism to the severity of respiratory viral disease	428
The expanding world of neuroscience	424
Structure and infection dynamics of mycobacteriophage Bxb1	417
Structural specializations of the sperm tail	414
Synthetic mammalian signaling circuits for robust cell population control	406
Genomic architecture of autism from comprehensive whole-genome sequence annotation	397
Mesoscopic mapping of the brain: From rodents to primates	394
COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas	393
Plasmodesmata act as unconventional membrane contact sites regulating intercellular molecular exchange in plants	392
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations	391
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center	390
Evolutionary assembly of cooperating cell types in an animal chemical defense system	378
Deciphering breast cancer: from biology to the clinic	363
Evolution and genetic adaptation of fishes to the deep sea	356
Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation	352
Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex	352
Macrophages at the interface of the co-evolving cancer ecosystem	350
Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin	339
A pan-cancer analysis of the microbiome in metastatic cancer	329
Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution	325
Ovarian cancer-derived IL-4 promotes immunotherapy resistance	324
Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite	319
Pursuing structural biology in China	307
Functional diversification of dietary plant small molecules by the gut microbiome	307
Structure-based discovery of CFTR potentiators and inhibitors	307
Precision medicine requires understanding how both sex and gender influence health	304
Fungal sugars boost vaccine protection	303
Unrealized potential from smaller institutions: Four strategies for advancing STEM diversity	303
An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms	303
To see is to experience: Aggression neurons light up when witnessing a fight	301
A gut-retching discovery	299
How do DEI initiatives impact STEMM, and why do we still need them?	297
The information theory of aging has not been tested	297
It took a long, long time: Ras and the race to cure cancer	296
Infodemics: A new challenge for public health	295
Structurally divergent and recurrently mutated regions of primate genomes	291

Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss	288
A mechano-resistance mechanism in skin adapts to terrestrial locomotion	284
Gut-liver axis calibrates intestinal stem cell fitness	281
Influence of autozygosity on common disease risk across the phenotypic spectrum	278
HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity	277
Sleep is required to consolidate odor memory and remodel olfactory synapses	272
Structural basis of respiratory complex adaptation to cold temperatures	270
Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration	270
Propofol: Milk of Amnesia	269
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1	268
A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis	268
Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition	267
Cell surface fluctuations regulate early embryonic lineage sorting	267
Structural basis for human Cav1.2 inhibition by multiple drugs and the neurotoxin calciseptine	267
Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function	263
Mechanism of IFT-A polymerization into trains for ciliary transport	262
Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy	262
Central nervous system regeneration	260
Microglia maintain structural integrity during fetal brain morphogenesis	257
DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs	255
Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals	255
A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement	254
Engineering RNA export for measurement and manipulation of living cells	254
Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity	253
Optimizing stem cell infusion timing in the prevention of acute graft-versus-host disease	253
SnapShot: Condensates in plant biology	251
Ancient hybridization underlies tuberization and radiation of the potato lineage	250
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification	249
The developmental basis of fingerprint pattern formation and variation	245
A genetic basis for sex differences in Xp11 translocation renal cell carcinoma	245
Multi-layered computational gene networks by engineered tristate logics	244
Spatial CRISPR genomics identifies regulators of the tumor microenvironment	239
Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding	234
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients	233
Hallmarks of neurodegenerative diseases	228
Nutrition, longevity and disease: From molecular mechanisms to interventions	227
A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior	226
Small-molecule hypoxia therapy in mitochondrial disease	225
The first two blastomeres contribute unequally to the human embryo	225
Gut microbiome ecological topology as next-generation biomarkers for cancer immunotherapy	224
SnapShot: Cell size control	220
Engineered cell entry links receptor biology with single-cell genomics	218
The genetic history of the Southern Caucasus from the Bronze Age to the Early Middle Ages: 5,000 years of genetic continuity despite high mobility	218
Celebrating our origins with cell biology	218
Small RNAs are modified with N-glycans and displayed on the surface of living cells	216
ExSPECKt the unexpected: NLRP3-caspase-8-dependent cell death in RBCs	215
Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution	213
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming	213
Multimodal charting of molecular and functional cell states via in situ electro-sequencing	211
Unraveling Mendel’s final mysteries: A genomic retelling of pea genetics	210
A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia	208
Tracing the origin of alveolar stem cells in lung repair and regeneration	205
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs	205
Ultrafast distant wound response is essential for whole-body regeneration	205
Immune checkpoint blockade provokes resident memory T cells to eliminate head and neck cancer	203
Fine particle air pollution and lung cancer risk: Extending the long list of health risks	203
Novel integrative elements and genomic plasticity in ocean ecosystems	203
Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network	203
Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations	200
Evolution of diapause in the African turquoise killifish by remodeling the ancient gene regulatory landscape	200
PIEZO2 in somatosensory neurons controls gastrointestinal transit	198
Mining metatranscriptomes reveals a vast world of viroid-like circular RNAs	197
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes	193
Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease	192
Freedom of expression: A synthetic route to metabolites	192
Virome characterization of game animals in China reveals a spectrum of emerging pathogens	190
A generative deep learning approach to de novo antibiotic design	189
An Arabidopsis single-nucleus atlas decodes leaf senescence and nutrient allocation	189
TGF-β signaling in health and disease	187
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays	185
Open-ST: High-resolution spatial transcriptomics in 3D	184
Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes	184
Pathogen protein modularity enables elaborate mimicry of a host phosphatase	181
An NK-like CAR T cell transition in CAR T cell dysfunction	180
Root microbiota regulates tiller number in rice	180
Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution	179
Intracellular calcium release: A conductor of compartmentalized dendritic plasticity	178
Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin	177
Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation	176
Paul Berg and the origins of recombinant DNA	174

Induced epigenetic changes memorized across generations in mice	174
Chromosome-level organization of the regulatory genome in the Drosophila nervous system	172
Sensational channels	172
Comparative landscape of genetic dependencies in human and chimpanzee stem cells	171
Small STEPs toward a big change	170
ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion	170
Snapshot: Choroid plexus brain barrier	169
Proteome-scale movements and compartment connectivity during the eukaryotic cell cycle	169
Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s?	169
ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors	168
The human proteome with direct physical access to DNA	167
Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy	167
Ancient host-associated microbes obtained from mammoth remains	166
Nothing about us without us: Sharing results with communities that provide genomic data	165
A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance	164
Mechanism of DNA capture by the MukBEF SMC complex and its inhibition by a viral DNA mimic	164
A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling	163
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic	163
ER stress transforms random olfactory receptor choice into axon targeting precision	163
A conserved family of immune effectors cleaves cellular ATP upon viral infection	163
Overcoming drug resistance in cancer	161
Structural insights into auxin influx mediated by the Arabidopsis AUX1	160
A general chemical principle for creating closure-stabilizing integrin inhibitors	159
A widely distributed gene cluster compensates for uricase loss in hominids	159
Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques	159
Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation	158
Jumbo phage killer immune system targets early infection of nucleus-forming phages	158
Intrinsic heterogeneity of primary cilia revealed through spatial proteomics	157
Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome	156
Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance	156
The extracellular matrix integrates mitochondrial homeostasis	156
GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA	155
Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants	155
Human microglial state dynamics in Alzheimer’s disease progression	153
Resmetirom for treatment of MASH	153
Bispecific dendritic-T cell engager potentiates anti-tumor immunity	152
Atlas of the aging mouse brain reveals white matter as vulnerable foci	152
Immunotherapy-related cognitive impairment after CAR T cell therapy in mice	151
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity	151
Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primates	150
Designing antibodies as therapeutics	148
High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients	148
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures	148
Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors	147
A neutrophil response linked to tumor control in immunotherapy	147
Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate	147
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway	147
Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin	147
Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT	147
Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection	147
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes	146
Spatial proteomics in neurons at single-protein resolution	146
Cancer biomarkers: Emerging trends and clinical implications for personalized treatment	146
Phage therapy: From biological mechanisms to future directions	146
Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases	146
Macrophages in health and disease	146
Systematic profiling reveals betaine as an exercise mimetic for geroprotection	144
Cancer neuroscience: State of the field, emerging directions	143
A multi-tissue metabolome atlas of primate pregnancy	142
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins	142
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant	140
Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture	140
Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution	140
The genetic history of Scandinavia from the Roman Iron Age to the present	139
Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans	139
Differential mosquito attraction to humans is associated with skin-derived carboxylic acid levels	138
How to build the virtual cell with artificial intelligence: Priorities and opportunities	137
Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions	137
Problem choice and decision trees in science and engineering	136
Before you call the midwife	136
Cervicovaginal microbiome and natural history of Chlamydia trachomatis in adolescents and young women	135
Mast cells regulate the brain-dura interface and CSF dynamics	134
Saturation mutagenesis-reinforced functional assays for disease-related genes	134
Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response	133
Medication effects on the gut microbiome in allo-HCT	133
Structural studies put phage defense mystery on the RADAR	133
Seven days in the life cycle of Homo sapiens	132
Schwann cell-secreted PGE2 promotes sensory neuron excitability during development	132
How NINJ1 mediates plasma membrane rupture and why NINJ2 cannot	131
Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development	131
Hormonal gatekeeping via the blood-brain barrier governs caste-specific behavior in ants	130
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability	130
Global identification of SWI/SNF targets reveals compensation by EP400	130
Integrative spatial analysis reveals a multi-layered organization of glioblastoma	129
Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease	129
Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer	129
Opposing GPCR signaling programs protein intake setpoint in Drosophila	128
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling	128
Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq	127
Human monoclonal antibodies targeting A35 protect from death caused by mpox	127
Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations	127
Bone marrow hematopoiesis drives multiple sclerosis progression	127
Staphylococcus scratches its itch	126
A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors	126
Harnessing social media to challenge scientific misinformation	126