Cell

Article	Citations
Patterning by contraction	5188
Prying the lid open: Atomic-level insights on sialoglycan-TMPRSS2 coordination in HKU1 entry	2644
Muscle fusogens go viral for gene delivery to skeletal muscle	1523
A sound mind in a sound body: Stress-induced glucocorticoids exacerbate gut inflammation	1499
Bound by the love for cholesterol: A transporter meets a GPCR	1065
CAR T therapy extends its reach to autoimmune diseases	1041
Procr+ chondroprogenitors sense mechanical stimuli to govern articular cartilage maintenance and regeneration	950
Choroid plexus mast cells drive tumor-associated hydrocephalus	872
Channel synapse mediates neurotransmission of airway protective chemoreflexes	871
In vitro human cell-based models: What can they do and what are their limitations?	855
Shaping pit structure in vessel walls sustains xylem hydraulics and grain yield	815
Keiji Tanaka (1949–2024)	743
The expanding world of neuroscience	732
Learning from HBCUs: How to produce Black professionals in STEMM	711
Global surveillance and countermeasures for ACE2-using MERS-related coronaviruses with spillover risk	708
EBV and MS: The evidence is growing stronger	681
Response to: The information theory of aging has not been tested	627
From periphery to center stage: 50 years of advancements in innate immunity	617
Structure and infection dynamics of mycobacteriophage Bxb1	614
OLAH connects fatty acid metabolism to the severity of respiratory viral disease	611
Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation	592
RNA quality control factors nucleate Clr4/SUV39H and trigger constitutive heterochromatin assembly	564
Retraction notice to: Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells	563
Five decades of advances in cancer research	563
Recycling of modified H2A-H2B provides short-term memory of chromatin states	553

In vivo DNA replication dynamics unveil aging-dependent replication stress	551
Can H5N1 avian influenza in dairy cattle be contained in the US?	544
PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development	524
Structures of LRP2 reveal a molecular machine for endocytosis	508
Interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses	506
Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome	498
Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells	473
Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution	468
Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin	463
Mesoscopic mapping of the brain: From rodents to primates	460
Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain	457
A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility	455
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis	453
Functional diversification of dietary plant small molecules by the gut microbiome	449
A pan-cancer analysis of the microbiome in metastatic cancer	429
Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias	424
Senescence-resistant human mesenchymal progenitor cells counter aging in primates	416
Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic	407
Evolution and genetic adaptation of fishes to the deep sea	396
Interferons in health and disease	396
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center	396
Structural basis for Cas9 off-target activity	385
Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex	385
Structural specializations of the sperm tail	381
Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma	379
Macrophages at the interface of the co-evolving cancer ecosystem	379
De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses	366
Structure-based discovery of CFTR potentiators and inhibitors	365
Ovarian cancer-derived IL-4 promotes immunotherapy resistance	365
Genomic architecture of autism from comprehensive whole-genome sequence annotation	363
A deep learning strategy to identify cell types across species from high-density extracellular recordings	355
Plasmodesmata act as unconventional membrane contact sites regulating intercellular molecular exchange in plants	354
A metabolic balance of GLP-1 and NMDA receptors in the brain	354
Deciphering breast cancer: from biology to the clinic	348
Pursuing structural biology in China	339
Propofol: Milk of Amnesia	338
Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration	336
Predicting competition and substrate preferences for targeted microbiome alteration	331
Planetary microbiome structure and generalist-driven gene flow across disparate habitats	329
Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss	327
Microglia maintain structural integrity during fetal brain morphogenesis	327
The first two blastomeres contribute unequally to the human embryo	317
A genetic basis for sex differences in Xp11 translocation renal cell carcinoma	315
An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms	314
Molecular characterization of Ebola virus glycoprotein V75A substitution in the 2018–2020 epidemic	312
Sleep is required to consolidate odor memory and remodel olfactory synapses	311
To see is to experience: Aggression neurons light up when witnessing a fight	308
A gut-retching discovery	305
How do DEI initiatives impact STEMM, and why do we still need them?	305
A mechano-resistance mechanism in skin adapts to terrestrial locomotion	302

SnapShot: Condensates in plant biology	300
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1	288
Precision medicine requires understanding how both sex and gender influence health	278
Establishing the relationship between brain cellular senescence and brain structure	278
The information theory of aging has not been tested	276
It took a long, long time: Ras and the race to cure cancer	275
HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity	275
Listening to the bladder field: Urine liquid biopsies reveal differential treatment responses in NMIBC	274
Structural basis for human Cav1.2 inhibition by multiple drugs and the neurotoxin calciseptine	271
Influence of autozygosity on common disease risk across the phenotypic spectrum	265
Structurally divergent and recurrently mutated regions of primate genomes	265
Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy	264
Mechanism of IFT-A polymerization into trains for ciliary transport	256
Nuclear envelope budding enables export of large transcripts in muscle cells	255
DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs	255
Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function	255
Engineering RNA export for measurement and manipulation of living cells	255
Optimizing stem cell infusion timing in the prevention of acute graft-versus-host disease	254
The evolution of high-order genome architecture revealed from 1,000 species	252
Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity	252
Structural basis of respiratory complex adaptation to cold temperatures	251
Gut-liver axis calibrates intestinal stem cell fitness	251
The developmental basis of fingerprint pattern formation and variation	248
A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis	247
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification	244
Multi-layered computational gene networks by engineered tristate logics	240
Ancient hybridization underlies tuberization and radiation of the potato lineage	237
Hallmarks of neurodegenerative diseases	233
Celebrating our origins with cell biology	231
Unraveling Mendel’s final mysteries: A genomic retelling of pea genetics	228
Gut microbiome ecological topology as next-generation biomarkers for cancer immunotherapy	227
Intracellular calcium release: A conductor of compartmentalized dendritic plasticity	227
Fine particle air pollution and lung cancer risk: Extending the long list of health risks	226
Small RNAs are modified with N-glycans and displayed on the surface of living cells	225
A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia	224
ExSPECKt the unexpected: NLRP3-caspase-8-dependent cell death in RBCs	224
Small-molecule hypoxia therapy in mitochondrial disease	219
Multimodal charting of molecular and functional cell states via in situ electro-sequencing	218
Striking a nerve: Sensory neurons orchestrate ECM remodeling and immune exclusion in TNBC	218
Ultrafast distant wound response is essential for whole-body regeneration	217
The genetic history of the Southern Caucasus from the Bronze Age to the Early Middle Ages: 5,000 years of genetic continuity despite high mobility	217
Immune checkpoint blockade provokes resident memory T cells to eliminate head and neck cancer	216
Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network	216
Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations	216
A phytoscreen identifies a garlic compound as a deterrent of mating and egg laying in Drosophila and mosquitoes	215
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming	214
Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes	214
Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution	213
PIEZO2 in somatosensory neurons controls gastrointestinal transit	213
SnapShot: Cell size control	213
Pathogen protein modularity enables elaborate mimicry of a host phosphatase	210
Open-ST: High-resolution spatial transcriptomics in 3D	209
Engineered cell entry links receptor biology with single-cell genomics	205
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs	202
Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease	201
Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution	200
A generative deep learning approach to de novo antibiotic design	198
Root microbiota regulates tiller number in rice	198
Tracing the origin of alveolar stem cells in lung repair and regeneration	197
Evolution of diapause in the African turquoise killifish by remodeling the ancient gene regulatory landscape	196
Mining metatranscriptomes reveals a vast world of viroid-like circular RNAs	196
Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation	193
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays	192
TGF-β signaling in health and disease	192
An Arabidopsis single-nucleus atlas decodes leaf senescence and nutrient allocation	191
Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin	190
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes	190
Small STEPs toward a big change	189
Novel integrative elements and genomic plasticity in ocean ecosystems	189
Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s?	188
Structural insights into auxin influx mediated by the Arabidopsis AUX1	187
Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution	187
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic	187
Paul Berg and the origins of recombinant DNA	186
Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity	184
Induced epigenetic changes memorized across generations in mice	183
A widely distributed gene cluster compensates for uricase loss in hominids	181
Nothing about us without us: Sharing results with communities that provide genomic data	180
Ancient host-associated microbes obtained from mammoth remains	180
Mechanism of DNA capture by the MukBEF SMC complex and its inhibition by a viral DNA mimic	179

Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection	179
ER stress transforms random olfactory receptor choice into axon targeting precision	178
Snapshot: Choroid plexus brain barrier	178
Bringing the genetically minimal cell to life on a computer in 4D	177
Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions	177
Development of non-spatial grid-like neural codes tracks inference and intelligence	176
Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primates	176
The extracellular matrix integrates mitochondrial homeostasis	176
Overcoming drug resistance in cancer	175
A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance	175
Jumbo phage killer immune system targets early infection of nucleus-forming phages	174
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration	174
Whole-organ and whole-body 3D atlases enable cellome-wide profiling	174
Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT	173
Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin	173
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway	173
Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture	172
Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema	172
Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants	172
Chromosome-level organization of the regulatory genome in the Drosophila nervous system	172
Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance	172
Comparative landscape of genetic dependencies in human and chimpanzee stem cells	171
Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans	169
Systematic profiling reveals betaine as an exercise mimetic for geroprotection	168
Proteome-scale movements and compartment connectivity during the eukaryotic cell cycle	167
Differential mosquito attraction to humans is associated with skin-derived carboxylic acid levels	167
A general chemical principle for creating closure-stabilizing integrin inhibitors	166
Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors	166
Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation	165
Arbitrium phages can manipulate each other’s lysis/lysogeny decisions	165
Human microglial state dynamics in Alzheimer’s disease progression	165
A neutrophil response linked to tumor control in immunotherapy	165
A conserved family of immune effectors cleaves cellular ATP upon viral infection	164
Designing antibodies as therapeutics	164
Macrophages in health and disease	163
Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature	162
Bispecific dendritic-T cell engager potentiates anti-tumor immunity	162
A multi-tissue metabolome atlas of primate pregnancy	161
Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy	160
Intrinsic heterogeneity of primary cilia revealed through spatial proteomics	159
High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients	159
ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion	158
Immunotherapy-related cognitive impairment after CAR T cell therapy in mice	157
Atlas of the aging mouse brain reveals white matter as vulnerable foci	156
Spatial proteomics in neurons at single-protein resolution	156
Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases	156
Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques	155
Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate	154
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes	154
Cancer biomarkers: Emerging trends and clinical implications for personalized treatment	154
The human proteome with direct physical access to DNA	152
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity	151
How to build the virtual cell with artificial intelligence: Priorities and opportunities	151
A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling	150
Resmetirom for treatment of MASH	150
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures	149
Cancer neuroscience: State of the field, emerging directions	149
The genetic history of Scandinavia from the Roman Iron Age to the present	149
Before you call the midwife	148
Phage therapy: From biological mechanisms to future directions	148
Medication effects on the gut microbiome in allo-HCT	146
Structural studies put phage defense mystery on the RADAR	146
Seven days in the life cycle of Homo sapiens	145
p53 safeguards chemical reprogramming of human somatic cells toward pluripotency	143
Harnessing social media to challenge scientific misinformation	143
Cervicovaginal microbiome and natural history of Chlamydia trachomatis in adolescents and young women	143
Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks	142
Hijacking ERAD for targeted degradation of transmembrane proteins	142
A percolation phase transition controls complement protein coating of surfaces	142
Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease	142
Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development	141
STING signaling modulation by COPII cargo recognition	141
Transport mechanism and pharmacology of the human GlyT1	140
Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer	139
Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response	139
Opposing GPCR signaling programs protein intake setpoint in Drosophila	138
Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program	137
Cytoplasmic division cycles without the nucleus and mitotic CDK/cyclin complexes	137
Hormonal gatekeeping via the blood-brain barrier governs caste-specific behavior in ants	137
A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors	136
Human monoclonal antibodies targeting A35 protect from death caused by mpox	135
Global identification of SWI/SNF targets reveals compensation by EP400	135
Schwann cell-secreted PGE2 promotes sensory neuron excitability during development	135
A circadian rheostat drives proton electrochemical gradients to optimize cell-type-specific growth in Arabidopsis	135
Problem choice and decision trees in science and engineering	135
Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer	134
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling	133
Saturation mutagenesis-reinforced functional assays for disease-related genes	133
Deep-learning-based de novo discovery and design of therapeutics that reverse disease-associated transcriptional phenotypes	132
A recipe for chaos: Extrachromosomal DNA and the hallmarks of cancer	132
Fibroblastic reticular cells generate protective intratumoral T cell environments in lung cancer	132
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration	131
How NINJ1 mediates plasma membrane rupture and why NINJ2 cannot	131
Mitochondria at the crossroads of health and disease	130
Guidelines for minimal information on cellular senescence experimentation in vivo	129