(The TQCC of Cell is 172. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)
Comprehensive Integration of Single-Cell Data6701
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease2738
Emerging Biological Principles of Metastasis1696
A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility1435
Reassessment of Exosome Composition1257
Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates1230
Biological Functions of Autophagy Genes: A Disease Perspective1197
Cohesin Loss Eliminates All Loop Domains1178
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies1116
Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment988
Cellular Senescence: Defining a Path Forward982
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma948
VEGF in Signaling and Disease: Beyond Discovery and Development886
Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma869
Multiscale 3D Genome Rewiring during Mouse Neural Development856
Predicting Splicing from Primary Sequence with Deep Learning847
Extensive Unexplored Human Microbiome Diversity Revealed by Over 150,000 Genomes from Metagenomes Spanning Age, Geography, and Lifestyle821
The Landscape of Circular RNA in Cancer793
Endogenous DNA Damage as a Source of Genomic Instability in Cancer769
Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses740
Lactate Metabolism in Human Lung Tumors715
Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging669
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders666
Genome Regulation by Polycomb and Trithorax: 70 Years and Counting661
The Role of Non-coding RNAs in Oncology639
Organoid Modeling of the Tumor Immune Microenvironment627
Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity617
Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory602
YY1 Is a Structural Regulator of Enhancer-Promoter Loops584
Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes577
Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis572
Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing554
Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma548
The U6 snRNA m 6 A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention546
Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming545
Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity541
The Missing Diversity in Human Genetic Studies532
A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging529
Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma525
Organization of Chromatin by Intrinsic and Regulated Phase Separation514
Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets498
Microglia Biology: One Century of Evolving Concepts498
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice498
Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains489
Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion489
Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner461
A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia452
Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer451
Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer450
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity438
Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding426
Commensal Microbiota Promote Lung Cancer Development via γδ T Cells414
Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields411
Autophagy-Independent Functions of the Autophagy Machinery405
Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity398
A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer394
Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood386
Marine DNA Viral Macro- and Microdiversity from Pole to Pole383
B Cell Responses: Cell Interaction Dynamics and Decisions381
Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3381
Metabolic Induction of Trained Immunity through the Mevalonate Pathway375
Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke372
Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses363
Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma359
Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy349
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities349
Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns348
Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes344
Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G337
A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart333
Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution319
RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity302
Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans302
A Compendium of Mutational Signatures of Environmental Agents301
Host and Environmental Factors Influencing Individual Human Cytokine Responses301
Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase299
The Energetics and Physiological Impact of Cohesin Extrusion298
A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling295
Structure of Microbial Nanowires Reveals Stacked Hemes that Transport Electrons over Micrometers293
The Translational Landscape of the Human Heart293
Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1291
Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity290
Trans Effects on Gene Expression Can Drive Omnigenic Inheritance287
Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization286
Atlas of Subcellular RNA Localization Revealed by APEX-Seq286
Ligand and Target Discovery by Fragment-Based Screening in Human Cells283
Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity282
A Drosophila Genetic Resource of Mutants to Study Mechanisms Underlying Human Genetic Diseases279
Illuminating G-Protein-Coupling Selectivity of GPCRs277
Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition271
R Loops: From Physiological to Pathological Roles267
Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain266
Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer266
Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells264
Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming264
Genomic Imprinting and Physiological Processes in Mammals263
Characterizing the Major Structural Variant Alleles of the Human Genome262
Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations260
A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens259
Molecular Classification and Comparative Taxonomics of Foveal and Peripheral Cells in Primate Retina258
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex258
Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis257
Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics256
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma256
BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis255
Structure and Engineering of Francisella novicida Cas9250
Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus250
Conversion of Escherichia coli to Generate All Biomass Carbon from CO2248
Widespread and Functional RNA Circularization in Localized Prostate Cancer247
Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity247
Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling246
Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence245
The cis-Regulatory Atlas of the Mouse Immune System243
The Coming Decade of Cell Death Research: Five Riddles240
Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders240
Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia239
Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone238
LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease237
NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer236
Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons236
Benchmarking Metagenomics Tools for Taxonomic Classification235
Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans235
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity234
The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn233
Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain232
Genomes of Subaerial Zygnematophyceae Provide Insights into Land Plant Evolution231
Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks229
GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance227
Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS227
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether226
Human Replay Spontaneously Reorganizes Experience224
Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung220
Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation219
Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis219
Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice217
The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest215
Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity215
Crystal Structure of the Human Cannabinoid Receptor CB2215
A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans213
Multiscale Structuring of the E. coli Chromosome by Nucleoid-Associated and Condensin Proteins211
CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset211
Tridimensional Visualization and Analysis of Early Human Development210
Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program210
B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer209
Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade207
Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites206
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity205
Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity203
Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity202
Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis201
Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance200
Global Trends in Marine Plankton Diversity across Kingdoms of Life197
Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging196
A Species-Wide Inventory of NLR Genes and Alleles in Arabidopsis thaliana196
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death195
Circuit Design Features of a Stable Two-Cell System195
Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions194
Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes193
FXR Regulates Intestinal Cancer Stem Cell Proliferation193
Controlling Visually Guided Behavior by Holographic Recalling of Cortical Ensembles191
Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain190
UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma190
Genetic Identification of Vagal Sensory Neurons That Control Feeding189
Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19189
p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression189
Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage188
A Host-Produced Quorum-Sensing Autoinducer Controls a Phage Lysis-Lysogeny Decision188
Gene Expression Changes and Community Turnover Differentially Shape the Global Ocean Metatranscriptome188
Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy187
orco Mutagenesis Causes Loss of Antennal Lobe Glomeruli and Impaired Social Behavior in Ants187
Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma186
Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool185
Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease183
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b182
Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity182
N-methyladenine DNA Modification in Glioblastoma180
Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae178
A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action177
Ultrafast Two-Photon Imaging of a High-Gain Voltage Indicator in Awake Behaving Mice176
Combined Social and Spatial Coding in a Descending Projection from the Prefrontal Cortex176
Telomere Length Determines TERRA and R-Loop Regulation through the Cell Cycle176
Super-Resolution Imaging of the Extracellular Space in Living Brain Tissue175
Mechanochemical Feedback Loops in Development and Disease174
Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10173
ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors173
Interspecies Competition Impacts Targeted Manipulation of Human Gut Bacteria by Fiber-Derived Glycans172
exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids172