Cell

Article	Citations
Integrated analysis of multimodal single-cell data	7835
Hallmarks of aging: An expanding universe	1688
Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity	1509
Adaptive immunity to SARS-CoV-2 and COVID-19	1425
Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology	1215
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications	1164
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity	1080
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes	1057
Mechanisms and disease consequences of nonalcoholic fatty liver disease	979
Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera	924
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2	892
SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies	841
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant	834
Hallmarks of response, resistance, and toxicity to immune checkpoint blockade	818
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses	804
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity	800
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2	770
The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic	733
A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells	732
Multiple early factors anticipate post-acute COVID-19 sequelae	704
Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin	682
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19	679
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays	665
Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy	664
SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron	650

Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer	622
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation	615
Gut-microbiota-targeted diets modulate human immune status	602
Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum	598
COVID-19-neutralizing antibodies predict disease severity and survival	594
Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants	590
Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum	575
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome	571
Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition	551
COVID-19 and the human innate immune system	551
Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19	545
COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas	533
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein	530
High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue	521
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity	513
A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice	505
Antibody evasion by the P.1 strain of SARS-CoV-2	504
Genome engineering for crop improvement and future agriculture	503
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells	479
Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma	478
Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches	478
Fibroblasts: Origins, definitions, and functions in health and disease	477
Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19	469
SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses	469
The basic immunology of asthma	469
Hallmarks of neurodegenerative diseases	460
β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway	457
Atherosclerosis: Recent developments	447
Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera	444
Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2	438
Circular RNAs: Characterization, cellular roles, and applications	433
Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19	432
Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant	428
Molecular topography of an entire nervous system	423
Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C)	422
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes	417
Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease	412
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors	411
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection	410
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity	408
Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer	397
Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2	395
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing	388
Massive expansion of human gut bacteriophage diversity	384
Bifidobacteria-mediated immune system imprinting early in life	378
High-coverage whole-genome sequencing of the expanded 1000 Genomes Project cohort including 602 trios	373
RNA-Mediated Feedback Control of Transcriptional Condensates	369
Adipose-tissue plasticity in health and disease	363
The origins of SARS-CoV-2: A critical review	361
Functional characterization of the dural sinuses as a neuroimmune interface	360

The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling	359
Spatially organized multicellular immune hubs in human colorectal cancer	356
Endometriosis: Etiology, pathobiology, and therapeutic prospects	352
Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells	339
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis	339
The antigenic anatomy of SARS-CoV-2 receptor binding domain	337
Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron	336
Humoral and cellular immune memory to four COVID-19 vaccines	335
Spatiotemporal analysis of human intestinal development at single-cell resolution	327
Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses	326
Telomeres: history, health, and hallmarks of aging	325
SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape	324
Small RNAs are modified with N-glycans and displayed on the surface of living cells	322
Pancreatic cancer: Advances and challenges	321
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy	321
Generation of Functional Human 3D Cortico-Motor Assembloids	320
The Tolman-Eichenbaum Machine: Unifying Space and Relational Memory through Generalization in the Hippocampal Formation	315
Microscopic examination of spatial transcriptome using Seq-Scope	314
Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection	314
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks	311
Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein	311
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins	311
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients	308
Multi-organ proteomic landscape of COVID-19 autopsies	306
The Rise of Molecular Glues	303
Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection	300
Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes	300
A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model	297
Pan-genome analysis of 33 genetically diverse rice accessions reveals hidden genomic variations	296
Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy	295
Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination	294
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation	293
Tackling COVID-19 with neutralizing monoclonal antibodies	291
Nitric oxide signaling in health and disease	290
A route to de novo domestication of wild allotetraploid rice	286
Proteogenomic characterization of pancreatic ductal adenocarcinoma	285
Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment	285
Co-option of Neutrophil Fates by Tissue Environments	283
Hallmarks of Health	282
Circular RNA vaccines against SARS-CoV-2 and emerging variants	281
Cardioids reveal self-organizing principles of human cardiogenesis	280
Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb	275
Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality	274
Maturation and persistence of the anti-SARS-CoV-2 memory B cell response	272
Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike	269
Mitocytosis, a migrasome-mediated mitochondrial quality-control process	263
Metabolic modeling of single Th17 cells reveals regulators of autoimmunity	262
Loss of epigenetic information as a cause of mammalian aging	260
Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution	259
Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States	258
Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer	258
Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine	258
SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2	252
Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species	251
The Geometry of Abstraction in the Hippocampus and Prefrontal Cortex	251
A single-cell atlas of chromatin accessibility in the human genome	249
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway	249
Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses	247
Immune checkpoint therapy—current perspectives and future directions	245
The JAK-STAT pathway at 30: Much learned, much more to do	244
Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration	243
Bacterial Retrons Function In Anti-Phage Defense	243
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis	243
In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies	242
Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer	240
Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq	236
CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment	235
BDNF signaling in context: From synaptic regulation to psychiatric disorders	235
Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses	235
Glioblastoma hijacks neuronal mechanisms for brain invasion	232
Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy	230
Spatially confined sub-tumor microenvironments in pancreatic cancer	230
The aging lung: Physiology, disease, and immunity	229
Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system	229
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19	225
RNA promotes the formation of spatial compartments in the nucleus	224
Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions	224
Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation	224
Mapping transcriptomic vector fields of single cells	224
Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2	219

Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells	219
Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis	219
Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules	217
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations	213
Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity	213
Macrophages in health and disease	212
The expanding amyloid family: Structure, stability, function, and pathogenesis	211
Glioma progression is shaped by genetic evolution and microenvironment interactions	211
Revisiting astrocyte to neuron conversion with lineage tracing in vivo	211
Cone-shaped HIV-1 capsids are transported through intact nuclear pores	211
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion	210
Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer	209
Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos	209
SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans	209
Hallmarks of environmental insults	209
Phage therapy: From biological mechanisms to future directions	209
An NK-like CAR T cell transition in CAR T cell dysfunction	208
What is a cell type and how to define it?	208
Biofuels for a sustainable future	207
A proteogenomic portrait of lung squamous cell carcinoma	207
Elevated rates of horizontal gene transfer in the industrialized human microbiome	207
Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption	207
An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies	206
Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma	206
Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact	205
Autism-related dietary preferences mediate autism-gut microbiome associations	203
Massively parallel assessment of human variants with base editor screens	200
The long-term genetic stability and individual specificity of the human gut microbiome	200
Therapeutic in vivo delivery of gene editing agents	199
A global metagenomic map of urban microbiomes and antimicrobial resistance	198
A Unified Framework for Dopamine Signals across Timescales	198
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer	198
T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals	196
Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages	196
A cis-regulatory atlas in maize at single-cell resolution	194
Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5	194
Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic	194
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity	191
Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes	191
Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development	191
The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages	189
The interferon landscape along the respiratory tract impacts the severity of COVID-19	189
Precision medicine in 2030—seven ways to transform healthcare	187
Persistent Cancer Cells: The Deadly Survivors	187
Extremely potent human monoclonal antibodies from COVID-19 convalescent patients	187
mTOR substrate phosphorylation in growth control	186
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity	185
ER-to-Golgi protein delivery through an interwoven, tubular network extending from ER	185
Novel approaches for vaccine development	183
A cellular and spatial map of the choroid plexus across brain ventricles and ages	182
Deciphering breast cancer: from biology to the clinic	182
Metastasis	181
A phosphate starvation response-centered network regulates mycorrhizal symbiosis	180
Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques	180
Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment	180
Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases	179
Cyclic CMP and cyclic UMP mediate bacterial immunity against phages	178
Antibody Affinity Shapes the Choice between Memory and Germinal Center B Cell Fates	178
Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis	178
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome	178
Phase Separation as a Missing Mechanism for Interpretation of Disease Mutations	178
Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production	178
Bioprinting for the Biologist	177
Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones	176
Compromised SARS-CoV-2-specific placental antibody transfer	175
Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19	175
Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates	174
Commensal Microbiota Modulation of Natural Resistance to Virus Infection	174
The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies	173
Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy	172
SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses	172
The Chinese pine genome and methylome unveil key features of conifer evolution	172
In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs	171
Large-scale two-photon calcium imaging in freely moving mice	170
Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis	170
Nutrition, longevity and disease: From molecular mechanisms to interventions	170
Infection trains the host for microbiota-enhanced resistance to pathogens	170
Structure and gating mechanism of the α7 nicotinic acetylcholine receptor	170
The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination	169
Structural insights into the human D1 and D2 dopamine receptor signaling complexes	168
Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity	167
Microbial exposure during early human development primes fetal immune cells	167
Functional interrogation of DNA damage response variants with base editing screens	167
An early cell shape transition drives evolutionary expansion of the human forebrain	167
Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia	165
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia	165
Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis	164
Whitefly hijacks a plant detoxification gene that neutralizes plant toxins	164
A cross-disorder dosage sensitivity map of the human genome	163
The role of extracellular vesicles in cancer	161
Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection	161
The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes	161
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques	160
Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior	159
NeuroPAL: A Multicolor Atlas for Whole-Brain Neuronal Identification in C. elegans	159