Cell

Article	Citations
In vitro human cell-based models: What can they do and what are their limitations?	3743
OLAH connects fatty acid metabolism to the severity of respiratory viral disease	2093
A metabolic balance of GLP-1 and NMDA receptors in the brain	1218
Prying the lid open: Atomic-level insights on sialoglycan-TMPRSS2 coordination in HKU1 entry	1169
Response to: The information theory of aging has not been tested	1076
The expanding world of neuroscience	900
Keiji Tanaka (1949–2024)	892
Ovarian cancer-derived IL-4 promotes immunotherapy resistance	879
COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas	818
Learning from HBCUs: How to produce Black professionals in STEMM	795
Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells	787
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations	776
De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses	767
Synthetic mammalian signaling circuits for robust cell population control	715
Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma	711
Interferons in health and disease	674
Structural specializations of the sperm tail	663
A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility	662
RNA quality control factors nucleate Clr4/SUV39H and trigger constitutive heterochromatin assembly	658
Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation	647
Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution	609
Bound by the love for cholesterol: A transporter meets a GPCR	553
In vivo DNA replication dynamics unveil aging-dependent replication stress	533
Structure and infection dynamics of mycobacteriophage Bxb1	510
Biosensors based on peptide exposure show single molecule conformations in live cells	503

Evolutionary assembly of cooperating cell types in an animal chemical defense system	502
Channel synapse mediates neurotransmission of airway protective chemoreflexes	484
Global surveillance and countermeasures for ACE2-using MERS-related coronaviruses with spillover risk	473
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center	466
Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain	465
Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite	463
Structure-based discovery of CFTR potentiators and inhibitors	461
PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development	457
CAR T therapy extends its reach to autoimmune diseases	455
A sound mind in a sound body: Stress-induced glucocorticoids exacerbate gut inflammation	453
Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome	450
Choroid plexus mast cells drive tumor-associated hydrocephalus	443
EBV and MS: The evidence is growing stronger	438
Muscle fusogens go viral for gene delivery to skeletal muscle	437
Reply to Over-celling fetal microbial exposure	433
Patterning by contraction	433
Evolution and genetic adaptation of fishes to the deep sea	423
Procr+ chondroprogenitors sense mechanical stimuli to govern articular cartilage maintenance and regeneration	414
Mesoscopic mapping of the brain: From rodents to primates	414
Senescence-resistant human mesenchymal progenitor cells counter aging in primates	413
Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias	397
From periphery to center stage: 50 years of advancements in innate immunity	393
Plasmodesmata act as unconventional membrane contact sites regulating intercellular molecular exchange in plants	387
A pan-cancer analysis of the microbiome in metastatic cancer	385
Functional diversification of dietary plant small molecules by the gut microbiome	380
Local hyperthermia therapy induces browning of white fat and treats obesity	378
Genomic architecture of autism from comprehensive whole-genome sequence annotation	377
Five decades of advances in cancer research	367
Interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses	359
Deciphering breast cancer: from biology to the clinic	349
A deep learning strategy to identify cell types across species from high-density extracellular recordings	344
Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex	343
Macrophages at the interface of the co-evolving cancer ecosystem	340
Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin	338
Structural basis for Cas9 off-target activity	332
Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic	322
Recycling of modified H2A-H2B provides short-term memory of chromatin states	319
Structures of LRP2 reveal a molecular machine for endocytosis	317
A mechano-resistance mechanism in skin adapts to terrestrial locomotion	304
Ancient hybridization underlies tuberization and radiation of the potato lineage	303
How do DEI initiatives impact STEMM, and why do we still need them?	302
Structural basis of respiratory complex adaptation to cold temperatures	302
Sleep is required to consolidate odor memory and remodel olfactory synapses	296
Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition	295
A gut-retching discovery	294
Influence of autozygosity on common disease risk across the phenotypic spectrum	294
Precision medicine requires understanding how both sex and gender influence health	290
Optimizing stem cell infusion timing in the prevention of acute graft-versus-host disease	289
Cell surface fluctuations regulate early embryonic lineage sorting	286
An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms	285

Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy	285
Propofol: Milk of Amnesia	278
Unrealized potential from smaller institutions: Four strategies for advancing STEM diversity	276
Mechanism of IFT-A polymerization into trains for ciliary transport	275
A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis	274
Microglia maintain structural integrity during fetal brain morphogenesis	272
Fungal sugars boost vaccine protection	271
To see is to experience: Aggression neurons light up when witnessing a fight	270
Engineering RNA export for measurement and manipulation of living cells	269
Pursuing structural biology in China	267
HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity	266
The information theory of aging has not been tested	266
SnapShot: Condensates in plant biology	263
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification	262
Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration	260
Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function	259
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1	259
The first two blastomeres contribute unequally to the human embryo	258
Multi-layered computational gene networks by engineered tristate logics	258
Structurally divergent and recurrently mutated regions of primate genomes	257
DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs	254
It took a long, long time: Ras and the race to cure cancer	253
A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement	250
Gut-liver axis calibrates intestinal stem cell fitness	250
Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity	249
Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals	248
A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior	246
Central nervous system regeneration	245
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients	245
Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding	244
A genetic basis for sex differences in Xp11 translocation renal cell carcinoma	244
Infodemics: A new challenge for public health	242
Structural basis for human Cav1.2 inhibition by multiple drugs and the neurotoxin calciseptine	241
Hallmarks of neurodegenerative diseases	241
Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss	239
Nutrition, longevity and disease: From molecular mechanisms to interventions	239
Spatial CRISPR genomics identifies regulators of the tumor microenvironment	238
The developmental basis of fingerprint pattern formation and variation	238
Small-molecule hypoxia therapy in mitochondrial disease	234
Celebrating our origins with cell biology	230
ExSPECKt the unexpected: NLRP3-caspase-8-dependent cell death in RBCs	228
Unraveling Mendel’s final mysteries: A genomic retelling of pea genetics	227
A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia	222
The genetic history of the Southern Caucasus from the Bronze Age to the Early Middle Ages: 5,000 years of genetic continuity despite high mobility	221
Small RNAs are modified with N-glycans and displayed on the surface of living cells	221
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming	218
Gut microbiome ecological topology as next-generation biomarkers for cancer immunotherapy	217
Evolution of diapause in the African turquoise killifish by remodeling the ancient gene regulatory landscape	213
SnapShot: Cell size control	211
Novel integrative elements and genomic plasticity in ocean ecosystems	211
Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network	209
Freedom of expression: A synthetic route to metabolites	209
Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation	207
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes	207
Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution	206
Multimodal charting of molecular and functional cell states via in situ electro-sequencing	202
Ultrafast distant wound response is essential for whole-body regeneration	201
Pathogen protein modularity enables elaborate mimicry of a host phosphatase	201
From microbial membrane proteins to the mysteries of emotion	200
Engineered cell entry links receptor biology with single-cell genomics	200
Mining metatranscriptomes reveals a vast world of viroid-like circular RNAs	199
Intracellular calcium release: A conductor of compartmentalized dendritic plasticity	198
Fine particle air pollution and lung cancer risk: Extending the long list of health risks	197
PIEZO2 in somatosensory neurons controls gastrointestinal transit	196
Immune checkpoint blockade provokes resident memory T cells to eliminate head and neck cancer	195
Root microbiota regulates tiller number in rice	194
Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease	193
A generative deep learning approach to de novo antibiotic design	193
Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution	191
TGF-β signaling in health and disease	190
Virome characterization of game animals in China reveals a spectrum of emerging pathogens	189
Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin	188
Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes	187
An Arabidopsis single-nucleus atlas decodes leaf senescence and nutrient allocation	186
Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations	185
Open-ST: High-resolution spatial transcriptomics in 3D	185
Tracing the origin of alveolar stem cells in lung repair and regeneration	184
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays	182
An NK-like CAR T cell transition in CAR T cell dysfunction	181
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs	179

Chromosome-level organization of the regulatory genome in the Drosophila nervous system	178
Structural insights into auxin influx mediated by the Arabidopsis AUX1	177
Paul Berg and the origins of recombinant DNA	176
Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans	174
Systematic profiling reveals betaine as an exercise mimetic for geroprotection	173
Immunotherapy-related cognitive impairment after CAR T cell therapy in mice	172
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures	170
Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s?	170
Nothing about us without us: Sharing results with communities that provide genomic data	169
Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques	169
Small STEPs toward a big change	167
Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution	167
Proteome-scale movements and compartment connectivity during the eukaryotic cell cycle	165
Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome	165
Sensational channels	163
ER stress transforms random olfactory receptor choice into axon targeting precision	163
Mechanism of DNA capture by the MukBEF SMC complex and its inhibition by a viral DNA mimic	163
Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT	162
A widely distributed gene cluster compensates for uricase loss in hominids	162
Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants	162
Snapshot: Choroid plexus brain barrier	162
Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture	161
A conserved family of immune effectors cleaves cellular ATP upon viral infection	160
Comparative landscape of genetic dependencies in human and chimpanzee stem cells	160
Induced epigenetic changes memorized across generations in mice	160
Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy	158
ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors	158
Bispecific dendritic-T cell engager potentiates anti-tumor immunity	157
Intrinsic heterogeneity of primary cilia revealed through spatial proteomics	156
A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling	155
Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors	154
A general chemical principle for creating closure-stabilizing integrin inhibitors	154
Spatial proteomics in neurons at single-protein resolution	154
Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions	153
Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate	151
Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection	151
The genetic history of Scandinavia from the Roman Iron Age to the present	151
Jumbo phage killer immune system targets early infection of nucleus-forming phages	151
Overcoming drug resistance in cancer	151
Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin	150
GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA	149
Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance	149
Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation	148
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant	148
ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion	148
A neutrophil response linked to tumor control in immunotherapy	147
A multi-tissue metabolome atlas of primate pregnancy	147
The extracellular matrix integrates mitochondrial homeostasis	146
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic	146
Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases	145
How to build the virtual cell with artificial intelligence: Priorities and opportunities	144
Human microglial state dynamics in Alzheimer’s disease progression	144
Macrophages in health and disease	144
High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients	143
Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primates	143
The human proteome with direct physical access to DNA	143
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway	143
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins	142
Ancient host-associated microbes obtained from mammoth remains	141
Resmetirom for treatment of MASH	141
Atlas of the aging mouse brain reveals white matter as vulnerable foci	141
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity	141
Cancer neuroscience: State of the field, emerging directions	140
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes	139
Phage therapy: From biological mechanisms to future directions	138
Cancer biomarkers: Emerging trends and clinical implications for personalized treatment	138
Designing antibodies as therapeutics	137
Differential mosquito attraction to humans is associated with skin-derived carboxylic acid levels	137
A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance	136
Staphylococcus scratches its itch	136
Cervicovaginal microbiome and natural history of Chlamydia trachomatis in adolescents and young women	135
A percolation phase transition controls complement protein coating of surfaces	135
Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response	134
Schwann cell-secreted PGE2 promotes sensory neuron excitability during development	134
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration	132
Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program	132
Seven days in the life cycle of Homo sapiens	132
Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development	132
Learning lessons from lipids to make COVID-19 vaccines	131
Before you call the midwife	131
Problem choice and decision trees in science and engineering	131
Saturation mutagenesis-reinforced functional assays for disease-related genes	130
Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations	130
Mast cells regulate the brain-dura interface and CSF dynamics	130
Emergency drug use in a pandemic: Harsh lessons from COVID-19	130
Cytoplasmic division cycles without the nucleus and mitotic CDK/cyclin complexes	129
Harnessing social media to challenge scientific misinformation	129
Medication effects on the gut microbiome in allo-HCT	129
Structural studies put phage defense mystery on the RADAR	128
Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer	127
How NINJ1 mediates plasma membrane rupture and why NINJ2 cannot	127
Transport mechanism and pharmacology of the human GlyT1	126
Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq	126
Opposing GPCR signaling programs protein intake setpoint in Drosophila	126
Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease	125