Cell

Article	Citations
Response to: The information theory of aging has not been tested	3569
The expanding world of neuroscience	2034
Patterning by contraction	1187
Keiji Tanaka (1949–2024)	1127
Muscle fusogens go viral for gene delivery to skeletal muscle	1021
A sound mind in a sound body: Stress-induced glucocorticoids exacerbate gut inflammation	895
Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias	877
Bound by the love for cholesterol: A transporter meets a GPCR	876
In vivo DNA replication dynamics unveil aging-dependent replication stress	789
Structure-based discovery of CFTR potentiators and inhibitors	783
EBV and MS: The evidence is growing stronger	777
Mesoscopic mapping of the brain: From rodents to primates	767
Reply to Over-celling fetal microbial exposure	725
Channel synapse mediates neurotransmission of airway protective chemoreflexes	692
Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation	689
Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin	660
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center	652
Choroid plexus mast cells drive tumor-associated hydrocephalus	647
Structures of LRP2 reveal a molecular machine for endocytosis	628
De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses	606
From periphery to center stage: 50 years of advancements in innate immunity	593
In vitro human cell-based models: What can they do and what are their limitations?	561
OLAH connects fatty acid metabolism to the severity of respiratory viral disease	532
Interferons in health and disease	493
Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain	475

Ovarian cancer-derived IL-4 promotes immunotherapy resistance	470
Evolution and genetic adaptation of fishes to the deep sea	467
Interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses	457
Learning from HBCUs: How to produce Black professionals in STEMM	457
Evolutionary assembly of cooperating cell types in an animal chemical defense system	456
PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development	454
CAR T therapy extends its reach to autoimmune diseases	450
A metabolic balance of GLP-1 and NMDA receptors in the brain	447
Prying the lid open: Atomic-level insights on sialoglycan-TMPRSS2 coordination in HKU1 entry	441
Procr+ chondroprogenitors sense mechanical stimuli to govern articular cartilage maintenance and regeneration	439
Biosensors based on peptide exposure show single molecule conformations in live cells	434
Senescence-resistant human mesenchymal progenitor cells counter aging in primates	428
Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite	422
Structural specializations of the sperm tail	418
Structure and infection dynamics of mycobacteriophage Bxb1	416
RNA quality control factors nucleate Clr4/SUV39H and trigger constitutive heterochromatin assembly	416
Five decades of advances in cancer research	413
Recycling of modified H2A-H2B provides short-term memory of chromatin states	413
A deep learning strategy to identify cell types across species from high-density extracellular recordings	411
Plasmodesmata act as unconventional membrane contact sites regulating intercellular molecular exchange in plants	410
A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility	400
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations	392
Global surveillance and countermeasures for ACE2-using MERS-related coronaviruses with spillover risk	391
COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas	388
Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex	385
Synthetic mammalian signaling circuits for robust cell population control	376
Macrophages at the interface of the co-evolving cancer ecosystem	373
Functional diversification of dietary plant small molecules by the gut microbiome	372
Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma	370
Structural basis for Cas9 off-target activity	363
Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution	363
Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells	359
Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome	350
Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic	346
Genomic architecture of autism from comprehensive whole-genome sequence annotation	335
A pan-cancer analysis of the microbiome in metastatic cancer	334
Deciphering breast cancer: from biology to the clinic	326
Local hyperthermia therapy induces browning of white fat and treats obesity	326
A gut-retching discovery	324
Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function	321
How do DEI initiatives impact STEMM, and why do we still need them?	321
Influence of autozygosity on common disease risk across the phenotypic spectrum	317
A mechano-resistance mechanism in skin adapts to terrestrial locomotion	306
Sleep is required to consolidate odor memory and remodel olfactory synapses	305
A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement	300
Precision medicine requires understanding how both sex and gender influence health	299
The first two blastomeres contribute unequally to the human embryo	295
Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals	294
Parallel and distributed encoding of speech across human auditory cortex	290
Gut-liver axis calibrates intestinal stem cell fitness	288

DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs	285
Mechanism of IFT-A polymerization into trains for ciliary transport	284
Optimizing stem cell infusion timing in the prevention of acute graft-versus-host disease	283
Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss	282
Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding	279
Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic	277
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients	276
To see is to experience: Aggression neurons light up when witnessing a fight	276
Fungal sugars boost vaccine protection	275
Pursuing structural biology in China	272
The information theory of aging has not been tested	269
HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity	262
It took a long, long time: Ras and the race to cure cancer	259
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1	256
A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis	256
Building and supporting identity in peer review	255
Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition	255
Ancient hybridization underlies tuberization and radiation of the potato lineage	255
A genetic basis for sex differences in Xp11 translocation renal cell carcinoma	253
Structural basis of respiratory complex adaptation to cold temperatures	253
Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy	252
Propofol: Milk of Amnesia	252
The developmental basis of fingerprint pattern formation and variation	250
Spatial CRISPR genomics identifies regulators of the tumor microenvironment	249
Engineering RNA export for measurement and manipulation of living cells	249
Multi-layered computational gene networks by engineered tristate logics	249
An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms	248
Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity	247
Unrealized potential from smaller institutions: Four strategies for advancing STEM diversity	247
Cell surface fluctuations regulate early embryonic lineage sorting	247
A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior	245
Microglia maintain structural integrity during fetal brain morphogenesis	240
SnapShot: Condensates in plant biology	240
Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration	240
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification	239
Infodemics: A new challenge for public health	237
Hallmarks of neurodegenerative diseases	237
Nutrition, longevity and disease: From molecular mechanisms to interventions	236
Central nervous system regeneration	235
Structural basis for human Cav1.2 inhibition by multiple drugs and the neurotoxin calciseptine	233
The interferon landscape along the respiratory tract impacts the severity of COVID-19	233
Structurally divergent and recurrently mutated regions of primate genomes	232
Freedom of expression: A synthetic route to metabolites	231
From microbial membrane proteins to the mysteries of emotion	230
Celebrating our origins with cell biology	229
Intracellular calcium release: A conductor of compartmentalized dendritic plasticity	229
Immune checkpoint blockade provokes resident memory T cells to eliminate head and neck cancer	228
ExSPECKt the unexpected: NLRP3-caspase-8-dependent cell death in RBCs	226
Small-molecule hypoxia therapy in mitochondrial disease	224
Gut microbiome ecological topology as next-generation biomarkers for cancer immunotherapy	224
Unraveling Mendel’s final mysteries: A genomic retelling of pea genetics	224
Fine particle air pollution and lung cancer risk: Extending the long list of health risks	220
Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network	217
Engineered cell entry links receptor biology with single-cell genomics	216
Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes	216
Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations	213
Pathogen protein modularity enables elaborate mimicry of a host phosphatase	208
An Arabidopsis single-nucleus atlas decodes leaf senescence and nutrient allocation	206
Small RNAs are modified with N-glycans and displayed on the surface of living cells	205
Novel integrative elements and genomic plasticity in ocean ecosystems	204
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming	203
The genetic history of the Southern Caucasus from the Bronze Age to the Early Middle Ages: 5,000 years of genetic continuity despite high mobility	203
Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease	202
A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia	201
A generative deep learning approach to de novo antibiotic design	200
Root microbiota regulates tiller number in rice	197
Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin	197
Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution	196
Multimodal charting of molecular and functional cell states via in situ electro-sequencing	193
SnapShot: Cell size control	193
Evolution of diapause in the African turquoise killifish by remodeling the ancient gene regulatory landscape	193
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs	192
Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation	191
Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution	189
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes	189
Open-ST: High-resolution spatial transcriptomics in 3D	189
PIEZO2 in somatosensory neurons controls gastrointestinal transit	188
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality	186
Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer	184
Ultrafast distant wound response is essential for whole-body regeneration	183

An NK-like CAR T cell transition in CAR T cell dysfunction	183
Tracing the origin of alveolar stem cells in lung repair and regeneration	183
Virome characterization of game animals in China reveals a spectrum of emerging pathogens	183
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays	183
Mining metatranscriptomes reveals a vast world of viroid-like circular RNAs	182
TGF-β signaling in health and disease	181
Sensational channels	180
Small STEPs toward a big change	180
Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s?	178
Induced epigenetic changes memorized across generations in mice	178
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic	177
A general chemical principle for creating closure-stabilizing integrin inhibitors	177
ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors	176
Paul Berg and the origins of recombinant DNA	176
Overcoming drug resistance in cancer	174
Jumbo phage killer immune system targets early infection of nucleus-forming phages	174
Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin	174
Nothing about us without us: Sharing results with communities that provide genomic data	174
Snapshot: Choroid plexus brain barrier	174
Hippocampal neurons construct a map of an abstract value space	172
Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome	171
Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate	170
Mechanism of DNA capture by the MukBEF SMC complex and its inhibition by a viral DNA mimic	170
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures	169
Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy	168
Emergence of an early SARS-CoV-2 epidemic in the United States	165
Structural insights into auxin influx mediated by the Arabidopsis AUX1	164
Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions	164
Proteome-scale movements and compartment connectivity during the eukaryotic cell cycle	161
Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT	161
High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients	161
A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling	161
Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants	160
Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans	159
Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution	157
Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection	157
Human microglial state dynamics in Alzheimer’s disease progression	157
Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance	156
Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques	156
Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors	156
Chromosome-level organization of the regulatory genome in the Drosophila nervous system	156
Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture	155
Comparative landscape of genetic dependencies in human and chimpanzee stem cells	154
GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA	153
ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion	152
Systematic profiling reveals betaine as an exercise mimetic for geroprotection	152
The human proteome with direct physical access to DNA	152
The genetic history of Scandinavia from the Roman Iron Age to the present	151
Spatial proteomics in neurons at single-protein resolution	151
ER stress transforms random olfactory receptor choice into axon targeting precision	150
Atlas of the aging mouse brain reveals white matter as vulnerable foci	150
A conserved family of immune effectors cleaves cellular ATP upon viral infection	149
Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases	148
A widely distributed gene cluster compensates for uricase loss in hominids	147
Lrp1 is a host entry factor for Rift Valley fever virus	147
Differential mosquito attraction to humans is associated with skin-derived carboxylic acid levels	146
Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primates	146
Phage therapy: From biological mechanisms to future directions	146
A multi-tissue metabolome atlas of primate pregnancy	145
Cancer neuroscience: State of the field, emerging directions	145
A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance	144
Bispecific dendritic-T cell engager potentiates anti-tumor immunity	143
A neutrophil response linked to tumor control in immunotherapy	143
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway	142
Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion	142
How to build the virtual cell with artificial intelligence: Priorities and opportunities	142
Macrophages in health and disease	141
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes	141
Immunotherapy-related cognitive impairment after CAR T cell therapy in mice	141
Cancer biomarkers: Emerging trends and clinical implications for personalized treatment	141
Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation	140
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins	139
Resmetirom for treatment of MASH	139
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant	139
The extracellular matrix integrates mitochondrial homeostasis	138
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity	137
Designing antibodies as therapeutics	137
Structural studies put phage defense mystery on the RADAR	136
Cervicovaginal microbiome and natural history of Chlamydia trachomatis in adolescents and young women	136
Before you call the midwife	136
Problem choice and decision trees in science and engineering	136
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling	135
Transport mechanism and pharmacology of the human GlyT1	135
Schwann cell-secreted PGE2 promotes sensory neuron excitability during development	135
Saturation mutagenesis-reinforced functional assays for disease-related genes	135
Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations	134
Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response	134
Staphylococcus scratches its itch	132
Learning lessons from lipids to make COVID-19 vaccines	131
Harnessing social media to challenge scientific misinformation	129
Emergency drug use in a pandemic: Harsh lessons from COVID-19	128
Seven days in the life cycle of Homo sapiens	128
Mast cells regulate the brain-dura interface and CSF dynamics	128
Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development	128
Human monoclonal antibodies targeting A35 protect from death caused by mpox	128