(The median citation count of Cell is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-09-01 to 2023-09-01.)
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor14101
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein5571
Integrated analysis of multimodal single-cell data3839
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus3175
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-193135
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals2599
Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE21953
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues1676
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE21624
Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding1508
The Architecture of SARS-CoV-2 Transcriptome1507
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies1357
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-191348
Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity1307
The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity1225
Cellular Senescence: Defining a Path Forward1225
Adaptive immunity to SARS-CoV-2 and COVID-191149
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism1141
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract1075
Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells1030
Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology1011
Proteomic and Metabolomic Characterization of COVID-19 Patient Sera968
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment967
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity960
Toll-like Receptors and the Control of Immunity858
Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera847
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant814
SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies776
The Role of Non-coding RNAs in Oncology771
A Deep Learning Approach to Antibiotic Discovery768
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders751
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2741
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity727
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes722
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant703
The Global Phosphorylation Landscape of SARS-CoV-2 Infection702
Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma692
Molecular Architecture of the SARS-CoV-2 Virus650
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses644
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2643
Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies642
Organization of Chromatin by Intrinsic and Regulated Phase Separation613
Microglia Biology: One Century of Evolving Concepts608
Single-Cell Transcriptome Atlas of Murine Endothelial Cells602
The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic601
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase598
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19590
A Genomic Perspective on the Origin and Emergence of SARS-CoV-2574
Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19572
G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules558
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer558
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers551
Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2548
Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer537
Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum533
Mechanisms and disease consequences of nonalcoholic fatty liver disease528
Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19508
COVID-19-neutralizing antibodies predict disease severity and survival501
Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19499
Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy495
Clinically Applicable AI System for Accurate Diagnosis, Quantitative Measurements, and Prognosis of COVID-19 Pneumonia Using Computed Tomography486
Quantitative Proteomics of the Cancer Cell Line Encyclopedia485
Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery480
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity472
Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization466
RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation466
SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron463
Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin459
Antibody evasion by the P.1 strain of SARS-CoV-2457
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein454
Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells450
COVID-19 and the human innate immune system446
Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2445
A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity445
A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies444
Effects of COVID-19 on the Nervous System429
Plant Immunity: Danger Perception and Signaling415
Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera412
Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy412
Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies411
Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma411
Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum410
Multiple early factors anticipate post-acute COVID-19 sequelae408
A Thermostable mRNA Vaccine against COVID-19407
The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas404
Pan-Genome of Wild and Cultivated Soybeans401
Hallmarks of response, resistance, and toxicity to immune checkpoint blockade398
A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart398
Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease394
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells393
A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells387
Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19384
Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition383
A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2383
Major Impacts of Widespread Structural Variation on Gene Expression and Crop Improvement in Tomato379
COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas376
A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice375
Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C)371
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications370
SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses368
β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway359
Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2357
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma355
Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment354
A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA352
A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS349
Gut-microbiota-targeted diets modulate human immune status349
Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant348
Targeting Strategies for Tissue-Specific Drug Delivery347
Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer344
Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans344
Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients343
Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19341
Emerging Pandemic Diseases: How We Got to COVID-19341
Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations337
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome336
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection334
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS334
Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes331
Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection324
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma323
Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front321
High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue321
Hallmarks of aging: An expanding universe320
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation318
R Loops: From Physiological to Pathological Roles317
A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors316
Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells313
Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex312
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma311
Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear307
The Science of Antibiotic Discovery305
Genome engineering for crop improvement and future agriculture300
Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza299
SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape298
Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism298
Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis298
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity296
The Polygenic and Monogenic Basis of Blood Traits and Diseases295
The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease294
Conversion of Escherichia coli to Generate All Biomass Carbon from CO2292
Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations287
Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution285
A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart283
Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2282
Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain282
Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage280
Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing279
A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer279
Coast-to-Coast Spread of SARS-CoV-2 during the Early Epidemic in the United States278
Establishing or Exaggerating Causality for the Gut Microbiome: Lessons from Human Microbiota-Associated Rodents277
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity277
The origins of SARS-CoV-2: A critical review277
Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma276
The antigenic anatomy of SARS-CoV-2 receptor binding domain275
A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model269
The Self-Organizing Genome: Principles of Genome Architecture and Function269
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether269
RNA-Mediated Feedback Control of Transcriptional Condensates269
Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity268
The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution266
Genomes of Subaerial Zygnematophyceae Provide Insights into Land Plant Evolution265
Massive expansion of human gut bacteriophage diversity264
Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection263
Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease263
Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses259
A Genetic Map of the Response to DNA Damage in Human Cells257
Genome-Scale Imaging of the 3D Organization and Transcriptional Activity of Chromatin256
Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein255
The basic immunology of asthma255
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors255
Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice255
Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients252
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks252
Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron251
Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection250
The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling247
Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer247
Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma247
TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy246
B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer246
CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors245
Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains245
Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program244
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing243
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays242
Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells239
Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner238
Functional characterization of the dural sinuses as a neuroimmune interface238
Tackling COVID-19 with neutralizing monoclonal antibodies235
Molecular topography of an entire nervous system235
The Human and Mouse Enteric Nervous System at Single-Cell Resolution234
Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly234
Proteogenomic Characterization of Endometrial Carcinoma233
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes233
Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis233
Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches231
Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema231
The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis231
Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality229
Single-Cell Transcriptomic Atlas of Primate Ovarian Aging229
Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions229
Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants228
Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States227
Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction226
UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma224
Global Trends in Marine Plankton Diversity across Kingdoms of Life224
Genetic Identification of Vagal Sensory Neurons That Control Feeding223
Bifidobacteria-mediated immune system imprinting early in life222
Fibroblasts: Origins, definitions, and functions in health and disease222
Maturation and persistence of the anti-SARS-CoV-2 memory B cell response221
Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine219
The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway218
Gene Expression Changes and Community Turnover Differentially Shape the Global Ocean Metatranscriptome218
Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies218
Multi-organ proteomic landscape of COVID-19 autopsies218
Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy217
Small RNAs are modified with N-glycans and displayed on the surface of living cells214
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor213
How Machine Learning Will Transform Biomedicine212
Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells211
Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity211
Generation of Functional Human 3D Cortico-Motor Assembloids210
Molecular Choreography of Acute Exercise209
Integrative Proteomic Characterization of Human Lung Adenocarcinoma209
Tissue Determinants of Human NK Cell Development, Function, and Residence207
Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy206
Genomic Epidemiology of SARS-CoV-2 in Guangdong Province, China205
IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression204
SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2204
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy203
Ultrafast Two-Photon Imaging of a High-Gain Voltage Indicator in Awake Behaving Mice203
The Emerging Landscape of Immune Cell Therapies202
Spatiotemporal analysis of human intestinal development at single-cell resolution202
Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting202
Hallmarks of Health201
Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses199
A route to de novo domestication of wild allotetraploid rice199
Mitochondrial Diseases: Hope for the Future197
Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy196
Co-option of Neutrophil Fates by Tissue Environments196
Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes194
In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies194
Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate194
Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development191
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense191
Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb191
Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy191
Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system190
Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer190
Impact of GPCR Structures on Drug Discovery190
The Tolman-Eichenbaum Machine: Unifying Space and Relational Memory through Generalization in the Hippocampal Formation189
Interspecies Competition Impacts Targeted Manipulation of Human Gut Bacteria by Fiber-Derived Glycans189
The Rise of Molecular Glues189
Humoral and cellular immune memory to four COVID-19 vaccines187
Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis187
Structure of the Cardiac Sodium Channel186
Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output185
Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut184
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease184
Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells183
Endometriosis: Etiology, pathobiology, and therapeutic prospects182
High-Throughput Mapping of B Cell Receptor Sequences to Antigen Specificity182
Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination179
Microscopic examination of spatial transcriptome using Seq-Scope179
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer179
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis179
A Quantitative Proteome Map of the Human Body178
A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging177
Personalized Mapping of Drug Metabolism by the Human Gut Microbiome176
Click Chemistry in Proteomic Investigations175
Getting to the Cores of Autism175
Mapping the Fine-Scale Organization and Plasticity of the Brain Vasculature174
Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike173
Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures173
Pan-genome analysis of 33 genetically diverse rice accessions reveals hidden genomic variations172
Bacterial Retrons Function In Anti-Phage Defense172
Functional Enhancers Shape Extrachromosomal Oncogene Amplifications171
Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence171
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins170
Atherosclerosis: Recent developments169
Telomeres: history, health, and hallmarks of aging167
Noninvasive Early Identification of Therapeutic Benefit from Immune Checkpoint Inhibition167
Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production166
Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging166
Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome166
Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment164
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis164
Cardioids reveal self-organizing principles of human cardiogenesis164
Cellular and Molecular Probing of Intact Human Organs164
A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance163
Structural Basis of Human KCNQ1 Modulation and Gating162
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity162
An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies162
Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans161
A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection160
Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis160
Multimodal Analysis of Cell Types in a Hypothalamic Node Controlling Social Behavior159
Adipose-tissue plasticity in health and disease158
Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques158
Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells158
Roadmap for the Emerging Field of Cancer Neuroscience158
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition157
Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss157
Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution156
Extremely potent human monoclonal antibodies from COVID-19 convalescent patients156
Spatially organized multicellular immune hubs in human colorectal cancer156
T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals156
Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense155
Proteogenomic characterization of pancreatic ductal adenocarcinoma155
Structure of the Decorated Ciliary Doublet Microtubule154
Modulation of RNA Condensation by the DEAD-Box Protein eIF4A153
Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos153
Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic152
Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy152
Synaptic Specificity, Recognition Molecules, and Assembly of Neural Circuits152
Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells151
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19151
Circular RNAs: Characterization, cellular roles, and applications150
Maternal Fecal Microbiota Transplantation in Cesarean-Born Infants Rapidly Restores Normal Gut Microbial Development: A Proof-of-Concept Study149
Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex148
Co-incidence of Damage and Microbial Patterns Controls Localized Immune Responses in Roots148
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway148
The Geometry of Abstraction in the Hippocampus and Prefrontal Cortex146
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients146
The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages145
Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow145
RNA promotes the formation of spatial compartments in the nucleus145
Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior144
Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules144
Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures144
Hallmarks of environmental insults143
Compromised SARS-CoV-2-specific placental antibody transfer143
Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms143
Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration143
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells143
High-coverage whole-genome sequencing of the expanded 1000 Genomes Project cohort including 602 trios142
Constant Sub-second Cycling between Representations of Possible Futures in the Hippocampus142
The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies142
Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species141
Identification of a Master Regulator of Differentiation in Toxoplasma140
Antibody Affinity Shapes the Choice between Memory and Germinal Center B Cell Fates140
Mitocytosis, a migrasome-mediated mitochondrial quality-control process139
Metabolic modeling of single Th17 cells reveals regulators of autoimmunity139
Local Fatty Acid Channeling into Phospholipid Synthesis Drives Phagophore Expansion during Autophagy139
Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression139
Charting the Complexity of the Marine Microbiome through Single-Cell Genomics139
Massively parallel assessment of human variants with base editor screens139
Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses139
Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning138
Cone-shaped HIV-1 capsids are transported through intact nuclear pores138
Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis137
Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development137
Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors136
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation136
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling136
General Anesthesia Decouples Cortical Pyramidal Neurons136
Public health actions to control new SARS-CoV-2 variants135
SnapShot: Ferroptosis135
Optical Pooled Screens in Human Cells135
Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19134
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion134
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer134
Revisiting astrocyte to neuron conversion with lineage tracing in vivo134
Identifying and Interpreting Apparent Neanderthal Ancestry in African Individuals134
Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2134
SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms134
SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans133
A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation133
Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption133
SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses132
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques132
Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization132
Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response132
Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa131
Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer131
CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling130
Autism-related dietary preferences mediate autism-gut microbiome associations130
Competing Roles of Slow Oscillations and Delta Waves in Memory Consolidation versus Forgetting130
The Penium margaritaceum Genome: Hallmarks of the Origins of Land Plants130
Circular RNA vaccines against SARS-CoV-2 and emerging variants130
Spatially confined sub-tumor microenvironments in pancreatic cancer129
A global metagenomic map of urban microbiomes and antimicrobial resistance129
Psychedelic Psychiatry’s Brave New World129
Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact128
The interferon landscape along the respiratory tract impacts the severity of COVID-19128
Elevated rates of horizontal gene transfer in the industrialized human microbiome128
Sour Sensing from the Tongue to the Brain128
Extracellular DNA Promotes Efficient Extracellular Electron Transfer by Pyocyanin in Pseudomonas aeruginosa Biofilms127
Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing127
Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity126
Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection125
mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron125
Emerging Modalities and Implantable Technologies for Neuromodulation125
A cis-regulatory atlas in maize at single-cell resolution125
Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities124
Precision medicine in 2030—seven ways to transform healthcare124
An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells124
Race Matters124
Rare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch124
SnapShot: Extracellular Vesicles124
Metabolic Dynamics and Prediction of Gestational Age and Time to Delivery in Pregnant Women123
Converting Escherichia coli to a Synthetic Methylotroph Growing Solely on Methanol123
TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit123
CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment123
Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways123
Functional Long Non-coding RNAs Evolve from Junk Transcripts122
Infection trains the host for microbiota-enhanced resistance to pathogens122
A single-cell atlas of chromatin accessibility in the human genome121
ParB-type DNA Segregation Proteins Are CTP-Dependent Molecular Switches121
Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer121
In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs121
High-Throughput Mapping of Long-Range Neuronal Projection Using In Situ Sequencing120
Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis120
Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells120
Whitefly hijacks a plant detoxification gene that neutralizes plant toxins120
The aging lung: Physiology, disease, and immunity120
Structure and Function of Stator Units of the Bacterial Flagellar Motor119
Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body119
Persistent Cancer Cells: The Deadly Survivors119
Functionally Distinct Neuronal Ensembles within the Memory Engram119
Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis118
ER-to-Golgi protein delivery through an interwoven, tubular network extending from ER118
A Unified Framework for Dopamine Signals across Timescales118
A proteogenomic portrait of lung squamous cell carcinoma118
Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes117
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome117
Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise117
The long-term genetic stability and individual specificity of the human gut microbiome116
CBASS Immunity Uses CARF-Related Effectors to Sense 3′–5′- and 2′–5′-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection116
Novel approaches for vaccine development116
M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity115
A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies115
Commensal Microbiota Modulation of Natural Resistance to Virus Infection115
The expanding amyloid family: Structure, stability, function, and pathogenesis114
Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma114
Biofuels for a sustainable future114
Microbial exposure during early human development primes fetal immune cells114
A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis114
A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion114
Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases112
Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells111
LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis111
Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases111
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations111
An early cell shape transition drives evolutionary expansion of the human forebrain111
Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity111
An expanded universe of cancer targets111
Phase Separation as a Missing Mechanism for Interpretation of Disease Mutations110
Memory Sequencing Reveals Heritable Single-Cell Gene Expression Programs Associated with Distinct Cellular Behaviors110
Functional interrogation of DNA damage response variants with base editing screens110
Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior110
Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies110
Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair110
Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production109
HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis109
Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression109
Cyclic CMP and cyclic UMP mediate bacterial immunity against phages109
A cellular and spatial map of the choroid plexus across brain ventricles and ages108
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions107
Dynamic Stimulation of Visual Cortex Produces Form Vision in Sighted and Blind Humans107
TMEM41B Is a Pan-flavivirus Host Factor107
A phosphate starvation response-centered network regulates mycorrhizal symbiosis107
Structure and gating mechanism of the α7 nicotinic acetylcholine receptor107
Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer106
The In Situ Structure of Parkinson’s Disease-Linked LRRK2106
Atoms to Phenotypes: Molecular Design Principles of Cellular Energy Metabolism106
Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates106
Structural insights into the human D1 and D2 dopamine receptor signaling complexes106
A Pan-cancer Transcriptome Analysis Reveals Pervasive Regulation through Alternative Promoters106
Active and Repressed Chromatin Domains Exhibit Distinct Nucleosome Segregation during DNA Replication105
Bioprinting for the Biologist105
The Crystal Structure of a Biological Insulated Transmembrane Molecular Wire105
Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia105
Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs105
pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise105
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity104
Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine104
Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity104
The Mind of a Mouse104
Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages104
Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer104
All-Optical Electrophysiology Reveals the Role of Lateral Inhibition in Sensory Processing in Cortical Layer 1104
COVID-19 vaccines: Keeping pace with SARS-CoV-2 variants104
Glioblastoma hijacks neuronal mechanisms for brain invasion103
Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis103
Mapping transcriptomic vector fields of single cells103
Long-Lasting Rescue of Network and Cognitive Dysfunction in a Genetic Schizophrenia Model103
Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS103
Asymmetric Molecular Architecture of the Human γ-Tubulin Ring Complex103
Widespread Transcriptional Scanning in the Testis Modulates Gene Evolution Rates102
Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism102
TACAN Is an Ion Channel Involved in Sensing Mechanical Pain102
Targeting KRAS(G12C): From Inhibitory Mechanism to Modulation of Antitumor Effects in Patients102
BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection102
Clinically Applicable AI System for Accurate Diagnosis, Quantitative Measurements, and Prognosis of COVID-19 Pneumonia Using Computed Tomography102
An NK-like CAR T cell transition in CAR T cell dysfunction102
Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies101
A basophil-neuronal axis promotes itch101
An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission100