Journal of Allergy and Clinical Immunology

Article	Citations
2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group	471
Systemic and mucosal antibody responses specific to SARS-CoV-2 during mild versus severe COVID-19	293
Coronavirus disease 2019 in patients with inborn errors of immunity: An international study	272
EUFOREA expert board meeting on uncontrolled severe chronic rhinosinusitis with nasal polyps (CRSwNP) and biologics: Definitions and management	206
Drug allergy: A 2022 practice parameter update	201
COVID-19 in patients with primary and secondary immunodeficiency: The United Kingdom experience	188
Biomarkers in atopic dermatitis—a review on behalf of the International Eczema Council	178
Efficacy and safety of benralizumab in chronic rhinosinusitis with nasal polyps: A randomized, placebo-controlled trial	170
JAK inhibitors in the treatment of atopic dermatitis	167
IL-6 serum levels predict severity and response to tocilizumab in COVID-19: An observational study	166
Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: A randomized clinical trial	164
Immunogenicity of Pfizer-BioNTech COVID-19 vaccine in patients with inborn errors of immunity	155
Food allergy across the globe	153
Heritable risk for severe anaphylaxis associated with increased α-tryptase–encoding germline copy number at TPSAB1	150
Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19	134
New clinical diagnostic criteria for allergic bronchopulmonary aspergillosis/mycosis and its validation	134
Single-cell transcriptomics combined with interstitial fluid proteomics defines cell type–specific immune regulation in atopic dermatitis	133
Factors associated with adverse COVID-19 outcomes in patients with psoriasis—insights from a global registry–based study	127
The sputum microbiome, airway inflammation, and mortality in chronic obstructive pulmonary disease	127
Tape strips detect distinct immune and barrier profiles in atopic dermatitis and psoriasis	126
Potential mechanisms of anaphylaxis to COVID-19 mRNA vaccines	123
Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of patients with VEXAS	120
Efficacy and safety of mepolizumab in hypereosinophilic syndrome: A phase III, randomized, placebo-controlled trial	118
Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: A systematic review and network meta-analysis	116
Asthma-associated risk for COVID-19 development	114

Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon	113
Autoimmune chronic spontaneous urticaria	113
Asthma among hospitalized patients with COVID-19 and related outcomes	109
Regulating T-cell differentiation through the polyamine spermidine	108
Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1	103
Staphylococcus epidermidis protease EcpA can be a deleterious component of the skin microbiome in atopic dermatitis	101
Advances in asthma: New understandings of asthma’s natural history, risk factors, underlying mechanisms, and clinical management	99
Mechanisms and pathogenesis of chronic rhinosinusitis	99
Dietary fiber and SCFAs in the regulation of mucosal immunity	97
Monogenic autoinflammatory disorders: Conceptual overview, phenotype, and clinical approach	96
Randomized trial of early infant formula introduction to prevent cow’s milk allergy	96
Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C)	95
Health disparities in allergic and immunologic conditions in racial and ethnic underserved populations: A Work Group Report of the AAAAI Committee on the Underserved	93
Climate change and global issues in allergy and immunology	92
The molecular features of normal and atopic dermatitis skin in infants, children, adolescents, and adults	91
Single-cell RNA sequencing of psoriatic skin identifies pathogenic Tc17 cell subsets and reveals distinctions between CD8+ T cells in autoimmunity and cancer	89
COVID-19–associated multisystem inflammatory syndrome in children (MIS-C): A novel disease that mimics toxic shock syndrome—the superantigen hypothesis	87
Cytokine release syndrome and neurotoxicity following CAR T-cell therapy for hematologic malignancies	86
Clinical Olfactory Working Group consensus statement on the treatment of postinfectious olfactory dysfunction	86
IL-25 (IL-17E) in epithelial immunology and pathophysiology	86
Oral once-daily berotralstat for the prevention of hereditary angioedema attacks: A randomized, double-blind, placebo-controlled phase 3 trial	85
Severity grading system for acute allergic reactions: A multidisciplinary Delphi study	84
Atopic dermatitis displays stable and dynamic skin transcriptome signatures	84
Anakinra combined with methylprednisolone in patients with severe COVID-19 pneumonia and hyperinflammation: An observational cohort study	83
Multifaceted MRGPRX2: New insight into the role of mast cells in health and disease	82
Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestations	80
Mas-related G protein–coupled receptor X2 and its activators in dermatologic allergies	80
Practical guidance for the diagnosis and management of secondary hypogammaglobulinemia: A Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees	79
Compartmental immunophenotyping in COVID-19 ARDS: A case series	79
The HOME Core outcome set for clinical trials of atopic dermatitis	78
Upadacitinib plus topical corticosteroids in atopic dermatitis: Week 52 AD Up study results	78
Basophil reactivity to BNT162b2 is mediated by PEGylated lipid nanoparticles in patients with PEG allergy	78
Subepidermal blistering eruptions, including bullous pemphigoid, following COVID-19 vaccination	77
The role of aspirin desensitization followed by oral aspirin therapy in managing patients with aspirin-exacerbated respiratory disease: A Work Group Report from the Rhinitis, Rhinosinusitis and Ocular	77
SCID newborn screening: What we’ve learned	75
Antibody responses to the SARS-CoV-2 vaccine in individuals with various inborn errors of immunity	74
JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition	74
Phase 2 randomized, double-blind study of IL-17 targeting with secukinumab in atopic dermatitis	73
Single-cell transcriptomics applied to emigrating cells from psoriasis elucidate pathogenic versus regulatory immune cell subsets	73
A substantial neutrophilic inflammation as regular part of severe type 2 chronic rhinosinusitis with nasal polyps	73
Mild atopic dermatitis lacks systemic inflammation and shows reduced nonlesional skin abnormalities	73
The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases	72
Epithelialized tunnels are a source of inflammation in hidradenitis suppurativa	71
Novel hereditary angioedema linked with a heparan sulfate 3-O-sulfotransferase 6 gene mutation	70
Remibrutinib, a novel BTK inhibitor, demonstrates promising efficacy and safety in chronic spontaneous urticaria	70
Rethinking neutrophils and eosinophils in chronic rhinosinusitis	70
Confirmation of multiple endotypes in atopic dermatitis based on serum biomarkers	70
Therapeutic options for CTLA-4 insufficiency	68
Diverse immune mechanisms of allergen immunotherapy for allergic rhinitis with and without asthma	67
Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19	67

Mechanisms and biomarkers of inflammatory endotypes in chronic rhinosinusitis without nasal polyps	67
Cow’s milk protein β-lactoglobulin confers resilience against allergy by targeting complexed iron into immune cells	67
Global patterns in anaphylaxis due to specific foods: A systematic review	66
Single-cell analysis reveals innate lymphoid cell lineage infidelity in atopic dermatitis	66
Urbanized microbiota in infants, immune constitution, and later risk of atopic diseases	66
Hematopoietic cell transplantation in severe combined immunodeficiency: The SCETIDE 2006-2014 European cohort	66
Accuracy of penicillin allergy diagnostic tests: A systematic review and meta-analysis	65
Incidence of cancer after asthma development: 2 independent population-based cohort studies	65
Long-term efficacy and safety of omalizumab for nasal polyposis in an open-label extension study	65
Glucocorticoids and the cytokines IL-12, IL-15, and IL-18 present in the tumor microenvironment induce PD-1 expression on human natural killer cells	65
Peanut allergy diagnosis: A 2020 practice parameter update, systematic review, and GRADE analysis	65
Non–IgE-mediated anaphylaxis	64
Air pollution and lung function in children	64
Trained immunity and tolerance in innate lymphoid cells, monocytes, and dendritic cells during allergen-specific immunotherapy	64
The maternal gut microbiome during pregnancy and offspring allergy and asthma	63
CD4+ T-cell differentiation and function: Unifying glycolysis, fatty acid oxidation, polyamines NAD mitochondria	62
COVID-19 risk and outcomes in adult asthmatic patients treated with biologics or systemic corticosteroids: Nationwide real-world evidence	62
SARS-CoV-2 infection and viral load are associated with the upper respiratory tract microbiome	62
Neuroimmune communication regulating pruritus in atopic dermatitis	61
Association of frequent moisturizer use in early infancy with the development of food allergy	61
Novel insights into atopic dermatitis	61
Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk	61
Structural racism and its pathways to asthma and atopic dermatitis	61
Treatment of chronic or relapsing COVID-19 in immunodeficiency	60
CD4+ and CD8+ cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG4-related disease	60
Animal models of psoriasis—highlights and drawbacks	60
Gut microbiota development during infancy: Impact of introducing allergenic foods	59
Sputum microbiome profiles identify severe asthma phenotypes of relative stability at 12 to 18 months	59
Efficacy of early anti-inflammatory treatment with high doses of intravenous anakinra with or without glucocorticoids in patients with severe COVID-19 pneumonia	59
An open-label, proof-of-concept study of lirentelimab for antihistamine-resistant chronic spontaneous and inducible urticaria	59
Age and eczema severity, but not family history, are major risk factors for peanut allergy in infancy	58
A 300 IR sublingual tablet is an effective, safe treatment for house dust mite–induced allergic rhinitis: An international, double-blind, placebo-controlled, randomized phase III clinical trial	58
Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways	58
Airway smooth muscle pathophysiology in asthma	57
Uniting biobank resources reveals novel genetic pathways modulating susceptibility for atopic dermatitis	57
Molecular profiling of allergen-specific antibody responses may enhance success of specific immunotherapy	56
The epithelial barrier hypothesis proposes a comprehensive understanding of the origins of allergic and other chronic noncommunicable diseases	55
Prognostic factors for polyp recurrence in chronic rhinosinusitis with nasal polyps	55
Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma	54
Investigating asthma heterogeneity through shared and distinct genetics: Insights from genome-wide cross-trait analysis	54
Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N6-methyladenosine–dependent manner in atopic dermatitis and psoriasis	54
IL-33 signaling in sensory neurons promotes dry skin itch	54
Use of multiple epinephrine doses in anaphylaxis: A systematic review and meta-analysis	54
Optimizing investigation of suspected allergy to polyethylene glycols	54
Housing and asthma disparities	53
Immunophenotyping in pemphigus reveals a TH17/TFH17 cell–dominated immune response promoting desmoglein1/3-specific autoantibody production	53
Roles of innate lymphoid cells (ILCs) in allergic diseases: The 10-year anniversary for ILC2s	53
Single-cell RNA sequencing of mast cells in eosinophilic esophagitis reveals heterogeneity, local proliferation, and activation that persists in remission	52
Distinct cytokine profiles associated with COVID-19 severity and mortality	52
Whole genome sequencing identifies genetic variants associated with co-trimoxazole hypersensitivity in Asians	52
Early-life exposure to submicron particulate air pollution in relation to asthma development in Chinese preschool children	51
Activation of the 15-lipoxygenase pathway in aspirin-exacerbated respiratory disease	51
Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome	51
Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS)	51
Persistent, refractory, and biphasic anaphylaxis: A multidisciplinary Delphi study	51
Transcriptomic characterization of prurigo nodularis and the therapeutic response to nemolizumab	50
Mepolizumab for chronic rhinosinusitis with nasal polyps: Treatment efficacy by comorbidity and blood eosinophil count	50
Associations between COVID-19 and skin conditions identified through epidemiology and genomic studies	50
Differential induction of allergen-specific IgA responses following timothy grass subcutaneous and sublingual immunotherapy	50
The importance of the 2S albumins for allergenicity and cross-reactivity of peanuts, tree nuts, and sesame seeds	49
lnc-BAZ2B promotes M2 macrophage activation and inflammation in children with asthma through stabilizing BAZ2B pre-mRNA	49
The natural history of peanut and egg allergy in children up to age 6 years in the HealthNuts population-based longitudinal study	49
FcεR1-expressing nociceptors trigger allergic airway inflammation	49
Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers	49
JAK inhibitors for asthma	49
Novel antibody cocktail targeting Bet v 1 rapidly and sustainably treats birch allergy symptoms in a phase 1 study	48
Reframing racial and ethnic disparities in atopic dermatitis in Black and Latinx populations	48
Principles, potential, and limitations of ex vivo basophil activation by flow cytometry in allergology: A narrative review	48
Hereditary alpha tryptasemia is not associated with specific clinical phenotypes	48
A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI)	48
Integrated-omics endotyping of infants with rhinovirus bronchiolitis and risk of childhood asthma	48
COVID-19 risk stratification algorithms based on sTREM-1 and IL-6 in emergency department	48
Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency	47
Phenotype and risk factors of venom-induced anaphylaxis: A case-control study of the European Anaphylaxis Registry	47
Current insights into the genetics of food allergy	47
Pustular psoriasis: Molecular pathways and effects of spesolimab in generalized pustular psoriasis	47
Highways to hell: Mechanism-based management of cytokine storm syndromes	46
Dual function of Langerhans cells in skin TSLP-promoted TFH differentiation in mouse atopic dermatitis	46
The airway as a route of sensitization to peanut: An update to the dual allergen exposure hypothesis	46
Asivatrep, a TRPV1 antagonist, for the topical treatment of atopic dermatitis: Phase 3, randomized, vehicle-controlled study (CAPTAIN-AD)	46

Severe COVID-19 in an APS1 patient with interferon autoantibodies treated with plasmapheresis	46
Immunogenicity and tolerability of COVID-19 messenger RNA vaccines in primary immunodeficiency patients with functional B-cell defects	46
Airway administration of OM-85, a bacterial lysate, blocks experimental asthma by targeting dendritic cells and the epithelium/IL-33/ILC2 axis	45
Dissecting the complexity of γδ T-cell subsets in skin homeostasis, inflammation, and malignancy	45
Multidimensional study of the oral microbiome, metabolite, and immunologic environment in peanut allergy	45
Abnormality in the NK-cell population is prolonged in severe COVID-19 patients	45
Eight novel susceptibility loci and putative causal variants in atopic dermatitis	45
Molecular and clinical effects of selective tyrosine kinase 2 inhibition with deucravacitinib in psoriasis	45
C5aR inhibition of nonimmune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2–infected primary human airway epithelia	45
CaMKII oxidation regulates cockroach allergen–induced mitophagy in asthma	45
Novel insights into the TRPV3-mediated itch in atopic dermatitis	44
TH17 cells and corticosteroid insensitivity in severe asthma	44
Immunogenicity of the mRNA-1273 COVID-19 vaccine in adult patients with inborn errors of immunity	44
Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma	44
Rituximab and antimetabolite treatment of granulomatous and lymphocytic interstitial lung disease in common variable immunodeficiency	44
KIT as a master regulator of the mast cell lineage	44
Type 2–high asthma is associated with a specific indoor mycobiome and microbiome	44
Prevention and management of allergic reactions to food in child care centers and schools: Practice guidelines	43
Inflammatory heterogeneity in aspirin-exacerbated respiratory disease	43
Ara h 2–specific IgE is superior to whole peanut extract–based serology or skin prick test for diagnosis of peanut allergy in infancy	43
Staphylococcus aureus second immunoglobulin-binding protein drives atopic dermatitis via IL-33	43
Incidence rates of hospitalization and death from COVID-19 in patients with psoriasis receiving biological treatment: A Northern Italy experience	43
Defining baseline variability of serum tryptase levels improves accuracy in identifying anaphylaxis	43
IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism, and ameliorates airway hyperreactivity	42
Altered chromatin landscape in circulating T follicular helper and regulatory cells following grass pollen subcutaneous and sublingual immunotherapy	42
Comparative efficacy of mepolizumab, benralizumab, and dupilumab in eosinophilic asthma: A Bayesian network meta-analysis	42
Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma	42
Mechanisms of human drug-induced anaphylaxis	42
Novel insights into contact dermatitis	42
Treatment of granuloma annulare and suppression of proinflammatory cytokine activity with tofacitinib	42
Using data from food challenges to inform management of consumers with food allergy: A systematic review with individual participant data meta-analysis	42
Immunologic memory to SARS-CoV-2 in convalescent COVID-19 patients at 1 year postinfection	42
Gut microbiome and breast-feeding: Implications for early immune development	42
Cardiovascular changes during peanut-induced allergic reactions in human subjects	41
Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease	41
Updating the CoFAR Grading Scale for Systemic Allergic Reactions in Food Allergy	41
Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development	41
Efficacy and economics of targeted panel versus whole-exome sequencing in 878 patients with suspected primary immunodeficiency	41
The microbial origins of food allergy	41
Rapid and sustained effect of dupilumab on clinical and mechanistic outcomes in aspirin-exacerbated respiratory disease	41
Prevalence and characteristics of peanut allergy in US adults	40
Comorbidities of atopic dermatitis—what does the evidence say?	40
Epicutaneous immunotherapy for treatment of peanut allergy: Follow-up from the Consortium for Food Allergy Research	40
Endotype of allergic asthma with airway obstruction in urban children	39
Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age	39
The impact of environmental injustice and social determinants of health on the role of air pollution in asthma and allergic disease in the United States	39
Inflammatory molecular endotypes of nasal polyps derived from White and Japanese populations	39
TSLP drives acute TH2-cell differentiation in lungs	39
Mast cell–derived IL-13 downregulates IL-12 production by skin dendritic cells to inhibit the TH1 cell response to cutaneous antigen exposure	39
Structures and functions of the inflammasome engine	38
Sputum mast cell/basophil gene expression relates to inflammatory and clinical features of severe asthma	38
The diagnosis of severe combined immunodeficiency (SCID): The Primary Immune Deficiency Treatment Consortium (PIDTC) 2022 Definitions	38
Broad transcriptional response of the human esophageal epithelium to proton pump inhibitors	38
International retrospective study of allogeneic hematopoietic cell transplantation for activated PI3K-delta syndrome	38
Attenuating the atopic march: Meta-analysis of the dupilumab atopic dermatitis database for incident allergic events	38
Allergen immunotherapy for atopic dermatitis: Systematic review and meta-analysis of benefits and harms	38
Exposure to bisphenols and asthma morbidity among low-income urban children with asthma	37
Allergoid–mannan conjugates reprogram monocytes into tolerogenic dendritic cells via epigenetic and metabolic rewiring	37
Burden of preschool wheeze and progression to asthma in the UK: Population-based cohort 2007 to 2017	37
The Finnish Allergy Program 2008-2018: Society-wide proactive program for change of management to mitigate allergy burden	37
Allergen-specific T cells and clinical features of food allergy: Lessons from CoFAR immunotherapy cohorts	37
Intralymphatic immunotherapy improves grass pollen allergic rhinoconjunctivitis: A 3-year randomized placebo-controlled trial	37
Lung virome: New potential biomarkers for asthma severity and exacerbation	36
Bcl6 and Blimp1 reciprocally regulate ST2+ Treg–cell development in the context of allergic airway inflammation	36
Epithelial exosomal contactin-1 promotes monocyte-derived dendritic cell–dominant T-cell responses in asthma	36
Mast cells, cortistatin, and its receptor, MRGPRX2, are linked to the pathogenesis of chronic prurigo	36
A toxic palmitoylation of Cdc42 enhances NF-κB signaling and drives a severe autoinflammatory syndrome	36
Defective Sec61α1 underlies a novel cause of autosomal dominant severe congenital neutropenia	36
APRIL-dependent lifelong plasmacyte maintenance and immunoglobulin production in humans	36
Cold exposure impairs extracellular vesicle swarm–mediated nasal antiviral immunity	35
Cross-talk between IFN-γ and TWEAK through miR-149 amplifies skin inflammation in psoriasis	35
Enhanced early skin treatment for atopic dermatitis in infants reduces food allergy	35
Experience with cultured thymus tissue in 105 children	35
A population-based study on associations of stool microbiota with atopic diseases in school-age children	35
Elevation of activated neutrophils in chronic rhinosinusitis with nasal polyps	35
A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice	35
Skin tape proteomics identifies pathways associated with transepidermal water loss and allergen polysensitization in atopic dermatitis	35
Air pollution and IgE sensitization in 4 European birth cohorts—the MeDALL project	35
Routine KIT p.D816V screening identifies clonal mast cell disease in patients with Hymenoptera allergy regularly missed using baseline tryptase levels alone	35
The intersect of genetics, environment, and microbiota in asthma—perspectives and challenges	34
Basophils promote barrier dysfunction and resolution in the atopic skin	34
Insights into hidradenitis suppurativa	34
Atopic dermatitis and risk of autoimmune conditions: Population-based cohort study	34
Patients with mast cell activation symptoms and elevated baseline serum tryptase level have unique bone marrow morphology	34
Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3	34
Seasonal airway microbiome and transcriptome interactions promote childhood asthma exacerbations	33
Selected recent advances in understanding the role of human mast cells in health and disease	33
Inflammatory macrophage memory in nonsteroidal anti-inflammatory drug–exacerbated respiratory disease	33
Changes in Australian food anaphylaxis admission rates following introduction of updated allergy prevention guidelines	33
Evolution of epitope-specific IgE and IgG4 antibodies in children enrolled in the LEAP trial	33
Netherton syndrome subtypes share IL-17/IL-36 signature with distinct IFN-α and allergic responses	33
Determinants of omalizumab dose–related efficacy in oral immunotherapy: Evidence from a cohort of 181 patients	33
Pediatric asthma incidence rates in the United States from 1980 to 2017	33
Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma: A randomized, controlled, proof-of-activity trial	33
Targeting inducible costimulator expressed on CXCR5+PD-1+ TH cells suppresses the progression of pemphigus vulgaris	32