Journal of Allergy and Clinical Immunology

Article	Citations
News & Notes	295
Editorial Board	272
New insights into human atopic dermatitis provided by mouse models	232
Reply	191
Hemophagocytic lymphohistiocytosis–like hyperinflammation due to a de novo mutation in DPP9	188
Reply	186
Reply	181
Loss-of-phosphorylation of IKZF1 results in gain-of-function associated with immune dysregulation	170
Gene editing in allergic diseases: Identification of novel pathways and impact of deleting allergen genes	164
Trajectories and phenotypes of rhinitis and wheeze	155
Hematopoietic stem cell gene editing rescues B-cell development in X-linked agammaglobulinemia	154
Dupilumab for chronic spontaneous urticaria—marvelous or meek?	138
Utility of TH2 cell biomarkers to predict outcomes and treatment response in children with asthma	137
Dupilumab in patients with chronic spontaneous urticaria (LIBERTY-CSU CUPID): Two randomized, double-blind, placebo-controlled, phase 3 trials	131
Interactions between skin-resident dendritic and Langerhans cells and pain-sensing neurons	126
Preschool impulse oscillometry predicts active asthma and impaired lung function at school age	126
Examining disparities in biologic therapy initiation: The intersection of race/ethnicity and insurance type	113
Novel insights on the biology and immunologic effects of histamine: A road map for allergists and mast cell biologists	113
Primary Antibody Deficiencies: Curation Of Gene-Disease Relationships Using A ClinGen Validation Framework	106
The monogenic landscape of human infectious diseases	105
Sensory neuroimmune signaling in the pathogenesis of Stevens-Johnson syndrome and toxic epidermal necrolysis	102
Asthma and respiratory comorbidities	101
Effect of mepolizumab in airway remodeling in patients with late-onset severe asthma with an eosinophilic phenotype	101
Imaging eosinophil secretory granules: From storage containers to active, immune responder organelles	99
News & Notes	96

Non–IgE-mediated anaphylaxis	96
Information for Readers	92
Recent advances in the immunopathogenesis of severe asthma	89
News Beyond Our Pages	88
Clinical and humoral response after SARS-CoV-2 breakthrough infection in patients receiving immunosuppressant therapy	86
Loss of the TRPM4 channel in humans causes immune dysregulation with defective monocyte migration	85
A novel syndrome of silent rhinovirus-associated bronchoalveolitis in children with recurrent wheeze	85
IL-4–STAT6 axis amplifies histamine-induced vascular endothelial dysfunction and hypovolemic shock	83
Roles of innate lymphoid cells (ILCs) in allergic diseases: The 10-year anniversary for ILC2s	82
Eosinophil depletion with benralizumab is associated with attenuated mannitol airway hyperresponsiveness in severe uncontrolled eosinophilic asthma	82
Compositional similarity between indoor and human sputum microbiome	80
News Beyond Our Pages	80
Igniting the firestorm: The inflammasome in autoinflammatory syndromes	80
Table of Contents	79
Cover 1	78
Association between polymorphisms on chromosome 17q12-q21 and rhinovirus-induced interferon responses	78
Studies on activation and regulation of the coagulation cascade in chronic rhinosinusitis with nasal polyps	77
Clinical and molecular correlates of the Index of Severity for Eosinophilic Esophagitis	76
Information for Readers	75
Ssu72 regulates alveolar macrophage development and allergic airway inflammation by fine-tuning of GM-CSF receptor signaling	74
Oral mucosa effectively protects against peanut allergy in mice	74
Phenotype and risk factors of venom-induced anaphylaxis: A case-control study of the European Anaphylaxis Registry	74
Reflections on a half century of mentoring	74
A unique esophageal extracellular matrix proteome alters normal fibroblast function in severe eosinophilic esophagitis	73
Breathing unequal: Unmasking the link between environmental justice, air pollution, and asthma severity	73
Overactive WASp in X-linked neutropenia leads to aberrant B-cell division and accelerated plasma cell generation	73
The intersect of genetics, environment, and microbiota in asthma—perspectives and challenges	72
The Editors’ Choice	72
Reply	71
Cover 1	71
Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection via glucocorticoids	70
When Dumbo meets IKAROS: Fear and hubris	70
The deubiquitinase CYLD controls protective immunity against helminth infection by regulation of Treg cell plasticity	70
News beyond our pages	69
Brief Overview of This Month's JACI	67
Information for Readers	67
Editorial Board	66
A Special Thank-You to Our Reviewers	66
Continuing Medical Education Calendar	66
In lasting tribute: Dr Hans Bisgaard, January 24, 1955, to September 8, 2022	65
CXXC5 variant in an immunodeficient patient with a progressive loss of hematopoietic cells	64
Editorial Board	64
Bioactive lipids: Accessible indicators toward improved diagnosis and treatment of asthma	63
CME Calendar-AAAAI	62
Late-onset enteric virus infection associated with hepatitis (EVAH) in transplanted SCID patients	62
Safety of upadacitinib in moderate-to-severe atopic dermatitis: An integrated analysis of phase 3 studies	62
The Editors’ Choice	62
Dupilumab Reduces Biomarkers of Type 2 Inflammation in Adult and Adolescent Patients With Eosinophilic Esophagitis: Results From Parts A and C of a Three-Part, Phase 3 LIBERTY EoE TREET Study	62
Food insecurity and allergic diseases: A call to collective action	61
Continuing Medical Education Calendar	61

Continuing Medical Education Calendar	61
The Editors’ Choice	60
The Editors’ Choice	59
DEF6 deficiency, a mendelian susceptibility to EBV infection, lymphoma, and autoimmunity	59
News & Notes	59
The Editors’ Choice	58
Brief Overview of This Month's JACI	58
News Beyond Our Pages	58
CME Calendar-AAAAI	57
Underrepresentation of Black and Hispanic trainees in allergy and immunology training and certification pipeline	57
Managing Patients with Severe Asthma and Common Comorbidities of Atopy, Obesity & Depression/Anxiety: Real-world Effectiveness of Mepolizumab	57
Neutrophils: Knights in atopic armor	56
Editorial Board	56
The Editors’ Choice	55
Advances in chronic rhinosinusitis in 2020 and 2021	54
Table of Contents	54
Reversal of SLE and hemophagocytic lymphohistiocytosis caused by lysinuric protein intolerance through allogeneic hematopoietic stem cell transplantation	54
Information for Readers	54
Multilayer concept of autoimmune mechanisms and manifestations in inborn errors of immunity: Relevance for precision therapy	53
The Editors’ Choice	53
Mentoring: A lifetime cycle and key to successful career development	53
News & Notes	53
Impact of a Digital Asthma Intervention on Short-acting Beta-agonist (SABA) Medication Use Among Medicaid-enrolled Children in Southwest Detroit	52
Mast cell–derived IL-13 downregulates IL-12 production by skin dendritic cells to inhibit the TH1 cell response to cutaneous antigen exposure	52
Editorial Board	52
Asthma susceptibility: Learning from genetic diversity	52
Maternal exposures to acid suppressant medications or antibiotics and infant food allergy in a bronchiolitis cohort	52
Lipid mediators are detectable in the nasal epithelium and differ by asthma status in female subjects	52
Chemicals in moisturizers may promote type 2 inflammation and food allergy	51
Cover 1	51
Retinoic acid promotes fibrinolysis and may regulate polyp formation	50
The curious history behind a biologic-enriched cat food: Hyperimmune avian IgY as a means of oral adoptive passive immunization	50
News & Notes	50
Inequities in air pollution exposure and gaps in air quality monitoring	50
Caspase 8 sounds the alarm for allergic inflammation	50
CME Calendar-AAAAI	50
Table of Contents	49
Brief Overview of This Month's JACI	49
Cover 1	49
Information for Readers	49
Continuing Medical Education Calendar	48
Table of Contents	48
Information for Readers	48
Brief Overview of This Month's JACI	48
Maternal vitamin D status modifies the effects of early life tobacco exposure on child lung function	47
Avapritinib Decreased Symptom Burden in Patients With Indolent Systemic Mastocytosis in the Registrational Double-Blind, Placebo-Controlled PIONEER Study	47
SARS-CoV-2 entry factors are expressed in nasal, ocular, and oral tissues: implications for COVID-19 prophylaxes/therapeutics	47
Real-world evidence: Methods for assessing long-term health and effectiveness of allergy immunotherapy	47
Editorial Board	46
Clinical Olfactory Working Group consensus statement on the treatment of postinfectious olfactory dysfunction	46
Table of Contents	46
Association of the gut microbiome and metabolome with wheeze frequency in childhood asthma	46
Incidence rates of hospitalization and death from COVID-19 in patients with psoriasis receiving biological treatment: A Northern Italy experience	46
Information for Readers	46
Cellular and systemic energy metabolic dysregulation in asthma development—a hypothesis-generating approach	46
Identification of MOD000001, A Novel Highly Selective and Orally Available KIT Inhibitor Designed for Treatment of Mast Cell-Associated Disorders	46
Increased group 2 innate lymphoid cells in peripheral blood of adults with mastocytosis	45
Do regional geography and race influence management of chronic spontaneous urticaria?	45
Hypogammaglobulinemia and Risk of Infectious Complications in Patients Receiving Idecabtagene vicleucel	45
Cystatin SN is a potent upstream initiator of epithelial-derived type 2 inflammation in chronic rhinosinusitis	45
Chronic rhinosinusitis: Future treatments and unmet needs	45
CME Calendar-AAAAI	45
Nasopharyngeal airway dual-transcriptome of infants with severe bronchiolitis and risk of childhood asthma: A multicenter prospective study	45
Adherence of Child and Adolescent Patients Following Oral Immunotherapy to Peanuts	45
A powerful tool with a narrow focus: Aiming genome-wide association studies at chronic spontaneous urticaria	44
Table of Contents	44
Editorial Board	44
CME Calendar-AAAAI	44
Table of Contents	44
Cover 1	44
Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort	44
Asthma and carotid artery plaques	44
Immune health grades: Finding resilience in the COVID-19 pandemic and beyond	44
Cover 1	44
Glycosylation enhances allergenic activity of major bee venom allergen Api m 1 by adding IgE epitopes	43
Lung function fluctuation patterns unveil asthma and COPD phenotypes unrelated to type 2 inflammation	43
News beyond our pages	43
Efficacy Of Tezepelumab In Patients With Severe, Uncontrolled Asthma By Specific Perennial Allergen Immunoglobulin E Thresholds	43
Exercise-induced laryngeal obstruction: A step in the right direction	42
Trajectories of adiposity indicators and association with asthma and lung function in urban minority children	42

Improving the reporting of allergic adverse events during immunotherapy for food allergy	42
Brief Overview of This Month's JACI	42
Beyond obesity: The complex relationship between early growth trajectories and later lung function	42
Progress in understanding whether respiratory syncytial virus infection in infancy causes asthma in childhood	42
Interactions between host epigenetics and microbiota: Who does what to whom, when, and why?	41
Maternal IgE is transferred to fetuses with IgG and minimally sensitizes fetal/neonatal skin mast cells	41
Elevated NK-cell transcriptional signature and dysbalance of resting and activated NK cells in atopic dermatitis	41
Lung dopaminergic nerves facilitate the establishment of TH2 resident memory cells in early life	41
Reply	40
How are airborne allergens remembered by the immune system?	40
Hypogammaglobulinemia and immune dysregulation—not just 2 sides of a coin	39
Brief Overview of This Month's JACI	39
CME Calendar-AAAAI	39
From the farm to the big city: Emerging health effects of agricultural emissions on asthma	39
The promise of sublingual and other immunotherapy options for infants and toddlers with food allergy	39
Table of Contents	38
Table of Contents	38
British Columbia, Canada, as a bellwether for climate-driven respiratory and allergic disorders	38
CME Calendar-AAAAI	38
Patient-reported outcome measures for urticaria and angioedema	38
Occupational health disparities: The pandemic as prism and prod	38
Table of Contents	38
A Special Thank-You to Our Reviewers	38
News Beyond Our Pages	38
Treating asthma in the time of COVID	37
Meta-analysis of ACE inhibitor–induced angioedema identifies novel risk locus	37
Cover 1	37
Moving forward with allergen immunotherapy: The significance of real-world studies	37
Moving beyond medication: Assessment and interventions on environmental and social determinants are needed to reduce severe asthma	37
Abnormal biomarkers predict complex FAS or FADD defects missed by exome sequencing	37
Editorial Board	37
Circulating innate lymphoid cells (cILCs): Unconventional lymphocytes with hidden talents	37
IL-4 receptor alpha signaling alters oral food challenge and immunotherapy outcomes in mice	37
Simultaneous Quantification of Major Allergens in Early Introduction Foods using a Fluorescent Multiplex Array	37
Evaluation of Medical Readiness and Operational Efficiencies using a 2-dose Versus 3-dose Hepatitis-B Virus Vaccine Regimen in a Military Recruit Training Setting	36
Progressive Accumulation of Hyperinflammatory NKG2Dlow NK Cells in Early Life Defines a Novel Endotype of Severe Atopic Dermatitis	36
Charlson Comorbidity Index and National Early Warning Score 2: Predictors of Mortality in COVID-19 Hospitalizations	36
Enhanced Cytokine Production in Children with Cutaneous Mastocytosis	35
Predictors of Increased Eosinophilic Esophagitis (EoE) Disease Activity After Proton Pump Inhibitor Therapy	35
Characteristics of Patients with Food Allergy & Food Insecurity on a Prescription Supplemental Nutrition Program	35
Diagnostic Algorithms for Cashew Allergy in Children Reduce Oral Food Challenges and Overall Cost	35
Understanding Sesame Allergy in the Pediatric Population	35
Major Peanut Allergens Ara h 1, Ara h 2 and Ara h 8 Are Degraded and Fragmented Following High-Pressure and Temperature Autoclaving	35
Allergological evaluation of hypersensitivity drug reactions to betalactams in children	35
In silico exploration of atopic dermatitis phenotypes for clinical trial design optimization	35
Shorter Dosing Interval Is Associated With Multiple Doses Of Epinephrine Required To Resolve Allergic Reaction At Milk Oral Challenge	35
Real-world Dupilumab Use in a Pediatric Allergy Clinic	35
Clinical Characterization of Unresolved vs Resolved Chronic Cough Evaluated in a Primary Care Clinic	35
Variability of allergen quantity in commercially available peanut-containing foods	34
Food Insecurity and Food Allergy in Children of an Urban Minority Community: A Cross-Sectional Study	34
Obstetric Penicillin Allergy Evaluations	34
Pediatric Asthma Post Hospitalization Phone Calls Increase Parental Self-Efficacy and Reduce 90 Day Emergency Department Visits	34
Evaluating the Relationship Between Social Determinants of Health (SDoH), Patient Demographics, and Access to Biologics in Patients with Moderate-to-Severe Asthma in Bronx, NY	34
Development of a Mobile Naturalistic Exposure Chamber for Cat Dander	34
Actual real-world application of PROMs in Asthma and Rhinitis as advised by guidelines: PROMUSE Respiratory Study	34
Omalizumab Improves Outcomes In Patients With Nasal Polyps Regardless Of Their Asthma Status	34
Outcomes of Penicillin Allergy Testing in Children with High-Risk Reaction Histories	34
Dupilumab Efficacy in LIBERTY ASTHMA QUEST Patients With Uncontrolled, Moderate-to-Severe Asthma By Allergen Sensitization Status	33
Modulations Of Natural Delivery On Yogurt-induced Reduction Of Non-specific Skin Reactivity In Healthy Infants	33
Airway Hyperresponsiveness and Eosinophilic Airway Inflammation In Patients With Atopic Dermatitis	33
The Munich Atopy Prediction Study to discover patterns in the development of Type II inflammation	33
Impact of Essential Oil Based Nasal Spray Sinusol® on Sinonasal-Related Impairment	33
Effect Of Eczema On Asthma Control In Atopic Vs Non-Atopic Asthma Patients	33
Esophageal Mast cells in Eosinophilic Esophagitis Are Heterogeneous, Dynamically Activated and Locally Proliferate	32
LONG-TERM EFFECTIVENESS AND SAFETY OF BENRALIZUMAB FOR UNCONTROLLED EOSINOPHILIC ASTHMA IN REAL-WORD PRACTICE	32
Real-World Response To Anti-Eosinophil Biologics For Severe Eosinophilic Asthma	32
Effectiveness, Safety, and Patient-Reported Outcomes (PROs) in Patients With Hereditary Angioedema (HAE) From the United States and Canada Treated With Lanadelumab: 24-Month Data From the EMPOWER Stud	32
Clinical and Economic Burden of Patients With Severe Asthma Untreated With a Biologic in the United States, Overall and by Blood Eosinophil and Level of Asthma Control	32
Zip Codes with High Pediatric Asthma Hospital Encounters are Areas with Increased Social Needs – Lessons From Geo-Mapping Technology	32
Neonatal mice infected with human metapneumovirus demonstrate Th2 skewing with primary and secondary infection	32
Omalizumab treatment is associated with improvement in outcomes in children with asthma despite pretreatment serum IgE exceeding dosing guidelines	32
The Oral Eosinophil-lowering Drug Dexpramipexole Improves FEV1 Largely Thorough its Effect on FVC	32
The Impact of Donidalorsen Taken Every 8 Weeks in Patients With Hereditary Angioedema	31
Prevalence of Atopic Disorders among Pediatric Patients with Pulmonary and Disseminated Coccidioidomycosis	31
The Association between Public versus Private Insurance and Poor Asthma Control in the Pediatric Population Using the 2013 and 2018 National Health Interview Survey	31
Preferential Loss of Peripheral Non-Naïve CD4+ Lymphocytes in Pediatric Sepsis	31
Gastric Acid Suppression and Penicillin Allergy Label	31
Association between early postnatal exposure to PM2.5 and airway resistance among school-age children with asthma	31
The Effectiveness of a Clinically Driven Home-Based Intervention in Houston-Area African American Adults with Poorly Controlled Asthma	31
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of YH35324, a Novel Long-Acting High-Affinity IgETrap-Fc Fusion Protein, in Atopic Subjects with a Total IgE > 700 IU/mL	31
Bcl6-expressing Foxp3+ T cells Promote Production of Antigen-Specific IgE in Response to Airborne Ragweed Pollen Exposure	31
Comparison of Selected Health and Well Being Characteristics in Seniors with Hereditary Angioedema (HAE) and a Non-HAE Patient Matched Cohort	31
Monitoring of Nighttime Respiratory Patterns to Alert for Changes in Chronic Asthma Management	31
Internalizing behavior problems in early life are associated with the risk of childhood asthma: The COCOA study	31
Defining Cytokine Immune Profiles of Maternal Breast Milk Influencing Atopic Disease	30
Clinical Features Associated with a Treatment-Refractory Phenotype in Chronic Spontaneous Urticaria (CSU)	30
Clinical and Laboratory Characteristics of Adults with Refractory Chronic Urticaria at A Single Tertiary Center from 2002 and 2020	30
Food Protein Induced Enterocolitis Syndrome in an Allergy Department: More than Meets the Eye	30
A Retrospective Chart Review Evaluating Adherence to Biologic Therapy in Patients with Severe Asthma Seen in a Pediatric Tertiary Care Center	30
IL-6 and IL-10 Levels in Cord Blood and Its Comparison Between Neonates With or Without Family History of Allergy	30
Disease Burden and Physician-Reported Outcomes in Pediatric Patients With Hereditary Angioedema: Data From A Real-World Study	30
Safety of Antibiotic Drug Challenges in Children 5 Years and Younger	29
Asthma-Related Emergency Department Visits in Texas: Associations with Allergenic Pollen and Viruses	29
Evaluation of Aspirin/NSAID Hypersensitivity During Pregnancy	29
A Quality Improvement Initiative for Engaging Physicians in Inpatient Penicillin Allergy De-Labeling	29