OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacology Biochemistry and Behavior is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Editorial Board	40
Dual activation of 5-HT1A and μ-opioid receptors mediates dezocine's antidepressant effects in mice with comorbid pain and depression	32
Editorial Board	32
Chronic inflammatory pain reduces fentanyl intake during early acquisition of fentanyl self-administration, but does not change motivation to take fentanyl in male and female rats	32
Clozapine treatment during the adolescent period reverses behavioral deficits in a dual-hit mouse model combining prenatal stress and maternal immune activation	30
Maternal fluoxetine impairs synaptic transmission and plasticity in the medial prefrontal cortex and alters the structure and function of dorsal raphe nucleus neurons in offspring mice	30
PERK activation mediates neuroprotection against chronic unpredictable stress-induced neurobehavioral changes via the TFEB pathway	26
Prenatal serotonin depletion persistently disrupts social behavior and modulates ΔFosB and SERT expression in mice	26
The endowment effect and temporal discounting of drug and non-drug commodities	26
Fluoxetine attenuates the anxiolytic effects of the probiotic VSL#3 in a stress-vulnerable genetic line of aves in the chick social-separation stress test, a dual screening assay	23
Agomelatine with cognitive behavioral therapy reduces insomnia severity index and subjective units of distress scores than initial-dose clonazepam in moderate to severe insomnia patients: A quasi-expe	22
iTat transgenic mice exhibit hyper-locomotion in the behavioral pattern monitor after chronic exposure to methamphetamine but are unaffected by Tat expression	20
Pharmacological and genetic manipulation of glyoxalase-1 (GLO1) does not alter locomotor responses or conditioned place preference induced by cocaine or oxycodone.	20
Pramipexole decreases allodynia and hyperalgesia via NF-κB in astrocytes in rats with Parkinson's disease	20
Protein kinases in natural versus drug reward	20
Evidence of heterogeneity in the opioid withdrawal syndrome: Spontaneous and precipitated withdrawal	19
Increased anxiolytic effect in aged female rats and increased motoric behavior in aged male rats to acute alcohol administration: Comparison to younger animals	19
Prenatal maternal stress induces increased avoidance behavior in adolescent mice offspring	19
Anxiolytic-like effects of milk proteins	17
Editorial Board	16
Temporal dynamics of PDE4 inhibition in modulating novel object recognition memory consolidation and reconsolidation	16
Chronic cannabis use alters dACC-striatal glutamatergic balance	16
The dosage-dependent effects of cevimeline in preventing clozapine-induced dyslipidaemia in female rats	16
The novel synthesized naltrexone-related MOR antagonist AT-99 counteracts dopamine releasing and behavioral depressant morphine-induced effects	16
Challenge exposure to whole cigarette smoke condensate upregulates locomotor sensitization by stimulating α4β2 nicotinic acetylcholine receptors in the nucleus accumbens of rats	15

Reconsidering OCD pharmacotherapy: The case for levomilnacipran as a safer alternative to clomipramine	15
Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats	15
Prevention of MK-801-induced amnestic effect with combined activation of 5-HT1A and muscarinic receptors in mice	15
Simultaneous cocaine and ethanol self-administration promotes a sex-dimorphic pattern in drug-seeking behaviour and alters plasma amino acid profile related to glutamate homeostasis in young adult rat	14
Ramelteon protects against social defeat stress-associated abnormal behaviors	14
Drug discrimination learning: Interoceptive stimulus control of behavior and its implications for regulated and dysregulated drug intake	14
Depression-like behaviors in mouse model of Sjögren's syndrome: A role of gut–microbiota–brain axis	13
The 5-HT7 receptor antagonist SB 269970 ameliorates maternal fluoxetine exposure-induced impairment of synaptic plasticity in the prefrontal cortex of the offspring female mice	13
Region-specific alterations in the expression and phosphorylation of NMDA receptor subunits in the rat prefrontal cortex and dorsal striatum accompanying behavioral sensitization induced by cocaine an	13
Small molecule orexin agonist ROXA-47 enhances learning and memory in mice	13
Divergent emotional and autonomic responses to Cyberball in patients with opioid use disorder on opioid agonist treatment	13
Single cannabidiol administration affects anxiety-, obsessive compulsive-, object memory-, and attention-like behaviors in mice in a sex and concentration dependent manner	13
Acute exercise performed during the late consolidation phase improves memory persistence by hippocampal protein synthesis and catecholamine modulation	12
Nebulized and intraperitoneal ketamine have equivalent antidepressant-like effect in the forced swim and tail suspension tests in mice	12
Network dysregulation in depression: A synthesis of HPA Axis, BDNF signaling, and neurotransmitter interactions across multidimensional systems	12
Dual orexin receptor antagonists in insomnia: Toward a new therapeutic paradigm	12
Population-dependent impacts of para-chlorophenylalanine, a tryptophan hydroxylase inhibitor, on homebase formation and thigmotaxis in adult zebrafish	12
Editorial Board	12
The α2C-adrenoceptor antagonist JP-1302 controls behavioral parameters, tyrosine hydroxylase activity and receptor expression in a rat model of ketamine-induced schizophrenia-like deficits	12
Swiss-Webster and C57BL/6 mice are differentially sensitive to the stimulant effects of methamphetamine	11
Psychopharmacology across the Lifespan	11
Maternal ingestion of cannabidiol (CBD) in mice leads to sex-dependent changes in memory, anxiety, and metabolism in the adult offspring, and causes a decrease in survival to weaning age	11
Editorial Board	11
Editorial Board	11
Emerging medications and pharmacological treatment approaches for substance use disorders	11
Esketamine-mediated alleviation of electroconvulsive shock-induced memory impairment is associated with the regulation of mGluR5 in depressive-like rats	11
Sex differences on the response to antidepressants and psychobiotics following early life stress in rats	11
The inhibitory effect of nicotine on Lumbriculus variegatus stereotypical movements and locomotor activity	11
Sex differences in the antidepressant-like response and molecular events induced by the imidazoline-2 receptor agonist CR4056 in rats	11
Chronic administration of caffeine, modafinil, AVL-3288 and CX516 induces time-dependent complex effects on cognition and mood in an animal model of sleep deprivation	10
Structurally diverse fentanyl analogs yield differential locomotor activities in mice	10
Editorial Board	10
Interactions between lorcaserin and opioids: Ventilation and food-versus-drug choice	10
Footshock stress enhances morphine-induced reward but attenuates aversion in behavior and neural mechanisms	10
The role of short-chain fatty acids and neuroinflammation in PTSD pathogenesis: A gut microbial perspective	10
Ketamine modulates the exploratory dynamics and homebase-related behaviors of adult zebrafish	10
Methylone pre-exposure differentially impacts the aversive effects of MDPV and MDMA in male and female Sprague-Dawley rats: Implications for abuse vulnerability	10
Enantiomeric contributions to methamphetamine's bidirectional effects on basal and fentanyl-depressed respiration in mice	10
Anxiolytic-like effects of an mGluR 5 antagonist and a mGluR 2/3 agonist, and antidepressant-like effects of an mGluR 7 agonist in the chick social separation stress test, a dual-drug screening model	10
Mu-opioid receptor knockout on Foxp2-expressing neurons reduces aversion-resistant alcohol drinking	10
Editorial for the 50th anniversary of Pharmacology Biochemistry and Behavior	10
Differentially regulated targets in the fast-acting antidepressant effect of (R)-ketamine: A systems biology approach	10
Contextual and psychosocial factors influencing drug reward in humans: The importance of non-drug reinforcement	10
Microbiome depletion by broad-spectrum antibiotics does not influence demyelination and remyelination in cuprizone-treated mice	10
Adult and adolescent antipsychotic exposure increases delay discounting and diminishes behavioral flexibility in male C57BL/6 mice	9
Role of social context in addiction etiology and recovery	9
Blocking the ErbB pathway during adolescence affects the induction of anxiety-like behavior in young adult maternal immune activation offspring	9
Sex differences in serotonergic control of rat social behaviour	9
Preliminary investigation of the administration of biperiden to reduce relapses in individuals with cocaine/crack user disorder: A randomized controlled clinical trial	9
Biochemical challenges for testing novel anti-panic drugs in humans	9

Activation of NOS-cGMP pathways promotes stress-induced sensitization of behavioral responses in zebrafish	9
Sex differences in acute tolerance to the objective and subjective effects of alcohol	9
Neuroprotective effect of histamine H3 receptor blockade on methamphetamine-induced cognitive impairment in mice	9
Glucocorticoid- β-adrenoceptors interactions in the infralimbic cortex in acquisition and consolidation of auditory fear memory extinction in rats	9
Acute MK-801 increases measures of both sign-tracking and goal-tracking in male Sprague-Dawley rats	9
Danavorexton, a selective orexin 2 receptor agonist, provides a symptomatic improvement in a narcolepsy mouse model	9
Simultaneous use of venlafaxine and calcium channel blockers on tolerance to morphine: The role of mitochondrial damage and oxidative stress in the brain	8
IGF2 modulates behavioral and hippocampal changes induced by chronic cocaine exposure during adolescence in mice	8
Sex-dependent and long-lasting effects of adolescent sleep deprivation on social behaviors in adult mice	8
Sex, but not juvenile stress, affects reversal learning and DRL performance following cocaine administration	8
Dysregulation of kappa opioid receptor neuromodulation of lateral habenula synaptic function following a repetitive mild traumatic brain injury	8
Substance use disorder is the outcome of deviant socialization: A prospective investigation spanning childhood to adulthood	8
Differential reductions in alcohol consumption and cue-induced alcohol-seeking behavior following mGlu5 receptor inhibition in the prelimbic vs. infralimbic subregions of the rat prefrontal cortex	8
L-DOPA reverses the impaired working memory via lateral habenula Kv7.2 subunit-containing M-channels in experimental parkinsonism	8
Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression	8
Caffeic acid differentially modulates behavior and neurochemicals in chronic unpredictable mild stress and dexamethasone induced models of depression	8
Modulation of circuit oscillations in the rat anterior cingulate cortex (ACC) in vitro by mGlu2 metabotropic glutamate receptors and alleviation of the effects of phencyclidine-induced NMDA-receptor h	8
Chronic exposure of female mice to selective serotonin reuptake inhibitors during lactation induces vocal behavior deficits in pre-weaned offspring	8
Reinforcing and psychostimulant effects of carfentanil and morphine in mice	8
Gender differences in the relationship between nicotine exposure and symptoms of depression	8
The silent weight of stress: A biopsycholinguistic loop of cortisol, control, and the language of the self	8
Impulsivity and aggression in alcohol withdrawal syndrome is modulated by the interaction of ZNF804A and mTOR polymorphism	8
Unlocking the age-old secrets of reward and substance use	8
Advances in translating mGlu2 and mGlu3 receptor selective allosteric modulators as breakthrough treatments for affective disorders and alcohol use disorder	8
Naltrexone-bupropion combinations do not affect cocaine self-administration in humans	8
Environmental enrichment enhances the antidepressant effect of ketamine and ameliorates spatial memory deficits in adult rats	8
Editorial Board	8
The blockade of orexin receptors within the dentate gyrus of the hippocampus attenuated methamphetamine-induced reward learning during conditioning place preference	7
Alpha-pyrrolidinopentiothiophenone (α-PVT) activates the TLR–NF-κB–MAPK signaling pathway and proinflammatory cytokine production and induces behavioral sensitization in mice	7
Cocaine diminishes consolidation of cued fear memory in female rats through interactions with ventral hippocampal D2 receptors	7
Editorial Board	7
Ligands of the trace amine-associated receptors (TAARs): A new class of anxiolytics	7
The piperazine analogue para-fluorophenylpiperazine alters timing of the physiological effects of the synthetic cannabinoid receptor agonist AMB-FUBINACA, without changing its discriminative stimulus,	7
Implications of the endocannabinoid system and the therapeutic action of cannabinoids in autism spectrum disorder: A literature review	7
Low dose nicotine administration improves attentional performance in rats but is not blocked by nicotinic antagonists	7
Editorial Board	7
Early adolescent second-generation antipsychotic exposure produces long-term, post-treatment increases in body weight and metabolism-associated gene expression	7
Perinatal running training reversed postnatal anxiety and depressive-like behavior and cognitive impairment in mice following prenatal subchronic variable stress	7
ERK signaling is required for nicotine-induced conditional place preference by regulating neuroplasticity genes expression in male mice	7
Time course of plasticity-related alterations following the first exposure to amphetamine in juvenile rats	7
Deciphering the gut microbiota's (Coprococcus and Subdoligranulum) impact on depression: Network pharmacology and molecular dynamics simulation	7
Differential disruption of response alternation by precipitated Δ9-THC withdrawal and subsequent Δ9-THC abstinence in mice	7
Adolescent alcohol exposure modifies adult anxiety-like behavior and amygdala sensitivity to alcohol in rats: Increased c-Fos activity and sex-dependent microRNA-182 expression	7
Differential patterns of opioid and dopamine D1 receptor antagonism on nutritive and non-nutritive sweetener intakes in C57BL/6:129 hybrid mice relative to inbred C57BL/6 and 129 mice	7
Higher exploratory and vigilant behaviors related to higher central dopaminergic activities of Formosan wood mice (Apodemus semotus) in light-dark exploration tests	6
Theophylline reverses oxycodone's but not fentanyl's respiratory depression in mice while caffeine is ineffective against both opioids	6
Editorial Board	6
Differential rearing alters Fos in the accumbens core and ventral palidum following reinstatement of cocaine seeking in male Sprague-Dawley rats	6
Pentylenetetrazole kindling induces dynamic changes in GAD65 expression in hippocampal somatostatin interneurons	6
The antidepressant agomelatine attenuates morphine-induced reinstatement but not self-administration or precipitated withdrawal	6
Role of mGlu receptors in psychiatric disorders – Recent advances	6
Replication and extension of the subregion selectivity of glutamate-related changes within the nucleus accumbens associated with the incubation of cocaine-craving	6
Influence of the dose of ketamine used on schizophrenia-like symptoms in mice: A correlation study with TH, GAD67, and PPAR-γ	6
Postpartum scarcity-adversity inflicts sex-specific cerebellar adaptations and reward behaviors in adolescence	6
Creatine prevents ouabain-induced manic-like behavior by modulating GSK-3β via PI3K/AKT/mTOR pathway	6
Intranasal LAG3 antibody infusion induces microglia-dependent antidepressant effect by mobilizing astrocytic P2Y1R-mediated BDNF synthesis in the hippocampus	6
A systematic review of ketamine's anxiolytic potential in rodent behavioral models of anxiety and PTSD	6
Practical opinions for new fiber photometry users to obtain rigorous recordings and avoid pitfalls	6
The alpha-7 nicotinic acetylcholine receptor agonist GTS-21 does not affect food intake in rats	6
Repeated exposure to ethanol alters memory acquisition and neurotransmission parameters in zebrafish brain	6
Editorial Board	6
The role of reward in substance use disorders: Introduction to the special issue	6
α7 nicotinic acetylcholine receptors in the medial prefrontal cortex control rewarding but not aversive memory expression in a dopamine-sensitive manner	6
Ndufs4 KO mice: A model to study comorbid mood disorders associated with mitochondrial dysfunction	6
Kisspeptin-13 induces hyperalgesia and modulates the expression of opioid and glutamate receptors in mice	6
Eutylone history selectively impacts the rewarding and aversive effects of cocaine, MDMA, and eutylone in female Sprague-Dawley rats	6