OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacology Biochemistry and Behavior is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Do greater levels of in-cage waking inactivity in laboratory mice reflect a spontaneous depression-like symptom? A pharmacological investigation	92
Maternal fluoxetine impairs synaptic transmission and plasticity in the medial prefrontal cortex and alters the structure and function of dorsal raphe nucleus neurons in offspring mice	57
Editorial Board	54
Editorial Board	42
Chronic inflammatory pain reduces fentanyl intake during early acquisition of fentanyl self-administration, but does not change motivation to take fentanyl in male and female rats	38
Prenatal serotonin depletion persistently disrupts social behavior and modulates ΔFosB and SERT expression in mice	37
PERK activation mediates neuroprotection against chronic unpredictable stress-induced neurobehavioral changes via the TFEB pathway	34
Prenatal maternal stress induces increased avoidance behavior in adolescent mice offspring	31
The endowment effect and temporal discounting of drug and non-drug commodities	30
Pramipexole decreases allodynia and hyperalgesia via NF-κB in astrocytes in rats with Parkinson's disease	29
Increased anxiolytic effect in aged female rats and increased motoric behavior in aged male rats to acute alcohol administration: Comparison to younger animals	29
Agomelatine with cognitive behavioral therapy reduces insomnia severity index and subjective units of distress scores than initial-dose clonazepam in moderate to severe insomnia patients: A quasi-expe	28
Pharmacological and genetic manipulation of glyoxalase-1 (GLO1) does not alter locomotor responses or conditioned place preference induced by cocaine or oxycodone.	28
Anxiolytic-like effects of milk proteins	27
Protein kinases in natural versus drug reward	25
Attenuation of nicotine-induced rewarding and antidepressant-like effects in male and female mice lacking regulator of G-protein signaling 2	24
iTat transgenic mice exhibit hyper-locomotion in the behavioral pattern monitor after chronic exposure to methamphetamine but are unaffected by Tat expression	23
Fluoxetine attenuates the anxiolytic effects of the probiotic VSL#3 in a stress-vulnerable genetic line of aves in the chick social-separation stress test, a dual screening assay	23
Simultaneous cocaine and ethanol self-administration promotes a sex-dimorphic pattern in drug-seeking behaviour and alters plasma amino acid profile related to glutamate homeostasis in young adult rat	22
Challenge exposure to whole cigarette smoke condensate upregulates locomotor sensitization by stimulating α4β2 nicotinic acetylcholine receptors in the nucleus accumbens of rats	22
Reconsidering OCD pharmacotherapy: The case for levomilnacipran as a safer alternative to clomipramine	22
Prevention of MK-801-induced amnestic effect with combined activation of 5-HT1A and muscarinic receptors in mice	21
Editorial Board	21
Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats	20
Chronic cannabis use alters dACC-striatal glutamatergic balance	20

Editorial Board	20
Editorial Board	19
The dosage-dependent effects of cevimeline in preventing clozapine-induced dyslipidaemia in female rats	19
Ramelteon protects against social defeat stress-associated abnormal behaviors	18
The novel synthesized naltrexone-related MOR antagonist AT-99 counteracts dopamine releasing and behavioral depressant morphine-induced effects	18
Single cannabidiol administration affects anxiety-, obsessive compulsive-, object memory-, and attention-like behaviors in mice in a sex and concentration dependent manner	17
Drug discrimination learning: Interoceptive stimulus control of behavior and its implications for regulated and dysregulated drug intake	17
Sleep, psychiatric and socioeconomic factors associated with substance use in a large population sample: A cross-sectional study	16
The 5-HT7 receptor antagonist SB 269970 ameliorates maternal fluoxetine exposure-induced impairment of synaptic plasticity in the prefrontal cortex of the offspring female mice	16
Region-specific alterations in the expression and phosphorylation of NMDA receptor subunits in the rat prefrontal cortex and dorsal striatum accompanying behavioral sensitization induced by cocaine an	16
Acute exercise performed during the late consolidation phase improves memory persistence by hippocampal protein synthesis and catecholamine modulation	15
Population-dependent impacts of para-chlorophenylalanine, a tryptophan hydroxylase inhibitor, on homebase formation and thigmotaxis in adult zebrafish	15
Editorial Board	15
QCTA-1, a quinoline derivative, ameliorates pentylenetetrazole-induced kindling and memory comorbidity in mice: Involvement of antioxidant system of brain.	15
Sucrose intake and preference by Wistar Han rats are not influenced by sex or food/water deprivation	14
The α2C-adrenoceptor antagonist JP-1302 controls behavioral parameters, tyrosine hydroxylase activity and receptor expression in a rat model of ketamine-induced schizophrenia-like deficits	14
Editorial Board	14
Involvement of kynurenine pathway and N-methyl-d-aspartate receptors in the antidepressant-like effect of vilazodone in the tail suspension test in mice	14
Divergent emotional and autonomic responses to Cyberball in patients with opioid use disorder on opioid agonist treatment	14
Depression-like behaviors in mouse model of Sjögren's syndrome: A role of gut–microbiota–brain axis	14
Nebulized and intraperitoneal ketamine have equivalent antidepressant-like effect in the forced swim and tail suspension tests in mice	14
Behavioral and pharmacological interventions for the prevention and treatment of psychiatric disorders with children exposed to maltreatment	13
Cannabidiol treatment prevents drug reinstatement and the molecular alterations evoked by amphetamine on receptors and enzymes from dopaminergic and endocannabinoid systems in rats	13
Psychopharmacology across the Lifespan	13
Swiss-Webster and C57BL/6 mice are differentially sensitive to the stimulant effects of methamphetamine	13
Sex differences in the antidepressant-like response and molecular events induced by the imidazoline-2 receptor agonist CR4056 in rats	13
Esketamine-mediated alleviation of electroconvulsive shock-induced memory impairment is associated with the regulation of mGluR5 in depressive-like rats	12
Emerging medications and pharmacological treatment approaches for substance use disorders	12
Sex differences on the response to antidepressants and psychobiotics following early life stress in rats	12
Maternal ingestion of cannabidiol (CBD) in mice leads to sex-dependent changes in memory, anxiety, and metabolism in the adult offspring, and causes a decrease in survival to weaning age	12
The inhibitory effect of nicotine on Lumbriculus variegatus stereotypical movements and locomotor activity	12
Ketamine modulates the exploratory dynamics and homebase-related behaviors of adult zebrafish	12
Editorial Board	11
Preliminary investigation of the administration of biperiden to reduce relapses in individuals with cocaine/crack user disorder: A randomized controlled clinical trial	11
Methylone pre-exposure differentially impacts the aversive effects of MDPV and MDMA in male and female Sprague-Dawley rats: Implications for abuse vulnerability	11
Enantiomeric contributions to methamphetamine's bidirectional effects on basal and fentanyl-depressed respiration in mice	11
Contextual and psychosocial factors influencing drug reward in humans: The importance of non-drug reinforcement	11
Neuroprotective effect of histamine H3 receptor blockade on methamphetamine-induced cognitive impairment in mice	11
Mu-opioid receptor knockout on Foxp2-expressing neurons reduces aversion-resistant alcohol drinking	11
Editorial for the 50th anniversary of Pharmacology Biochemistry and Behavior	11
Anxiolytic-like effects of an mGluR 5 antagonist and a mGluR 2/3 agonist, and antidepressant-like effects of an mGluR 7 agonist in the chick social separation stress test, a dual-drug screening model	11
Interactions between lorcaserin and opioids: Ventilation and food-versus-drug choice	11
Differentially regulated targets in the fast-acting antidepressant effect of (R)-ketamine: A systems biology approach	10
Role of social context in addiction etiology and recovery	10
Biochemical challenges for testing novel anti-panic drugs in humans	10
Adult and adolescent antipsychotic exposure increases delay discounting and diminishes behavioral flexibility in male C57BL/6 mice	10
Chronic administration of caffeine, modafinil, AVL-3288 and CX516 induces time-dependent complex effects on cognition and mood in an animal model of sleep deprivation	10
L-DOPA reverses the impaired working memory via lateral habenula Kv7.2 subunit-containing M-channels in experimental parkinsonism	10
Footshock stress enhances morphine-induced reward but attenuates aversion in behavior and neural mechanisms	10
Structurally diverse fentanyl analogs yield differential locomotor activities in mice	10

Microbiome depletion by broad-spectrum antibiotics does not influence demyelination and remyelination in cuprizone-treated mice	10
Activation of NOS-cGMP pathways promotes stress-induced sensitization of behavioral responses in zebrafish	9
Modulation of mGlu5 improves sensorimotor gating deficits in rats neonatally treated with quinpirole through changes in dopamine D2 signaling	9
Gender differences in the relationship between nicotine exposure and symptoms of depression	9
5-HT2C agonists and antagonists block different components of behavioral responses to potential, distal, and proximal threat in zebrafish	9
Chronic exposure of female mice to selective serotonin reuptake inhibitors during lactation induces vocal behavior deficits in pre-weaned offspring	9
Impulsivity and aggression in alcohol withdrawal syndrome is modulated by the interaction of ZNF804A and mTOR polymorphism	9
A spotlight on HCV and SARS-CoV-2 co-infection and brain function	9
Blocking the ErbB pathway during adolescence affects the induction of anxiety-like behavior in young adult maternal immune activation offspring	9
Hippocampus-sensitive and striatum-sensitive learning one month after morphine or cocaine exposure in male rats	8
Glucocorticoid- β-adrenoceptors interactions in the infralimbic cortex in acquisition and consolidation of auditory fear memory extinction in rats	8
Acute MK-801 increases measures of both sign-tracking and goal-tracking in male Sprague-Dawley rats	8
Transmission of the adverse consequences of childhood maltreatment across generations: Focus on gestational biology	8
Modulation of circuit oscillations in the rat anterior cingulate cortex (ACC) in vitro by mGlu2 metabotropic glutamate receptors and alleviation of the effects of phencyclidine-induced NMDA-receptor h	8
Object recognition and Morris water maze to detect cognitive impairment from mild hippocampal damage in rats: A reflection based on the literature and experience	8
Differential reductions in alcohol consumption and cue-induced alcohol-seeking behavior following mGlu5 receptor inhibition in the prelimbic vs. infralimbic subregions of the rat prefrontal cortex	8
Environmental enrichment enhances the antidepressant effect of ketamine and ameliorates spatial memory deficits in adult rats	8
Danavorexton, a selective orexin 2 receptor agonist, provides a symptomatic improvement in a narcolepsy mouse model	8
Distinctively lower DISC1 mRNA levels in patients with schizophrenia, especially in those with higher positive, negative, and depressive symptoms	8
The romantic age of pharmacological science	8
Deciphering the gut microbiota's (Coprococcus and Subdoligranulum) impact on depression: Network pharmacology and molecular dynamics simulation	8
Simultaneous use of venlafaxine and calcium channel blockers on tolerance to morphine: The role of mitochondrial damage and oxidative stress in the brain	8
Dysregulation of kappa opioid receptor neuromodulation of lateral habenula synaptic function following a repetitive mild traumatic brain injury	8
Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression	8
Sex differences in serotonergic control of rat social behaviour	8
Editorial Board	8
Naltrexone-bupropion combinations do not affect cocaine self-administration in humans	8
Sex, but not juvenile stress, affects reversal learning and DRL performance following cocaine administration	8
Sex-dependent and long-lasting effects of adolescent sleep deprivation on social behaviors in adult mice	8
Advances in translating mGlu2 and mGlu3 receptor selective allosteric modulators as breakthrough treatments for affective disorders and alcohol use disorder	8
Substance use disorder is the outcome of deviant socialization: A prospective investigation spanning childhood to adulthood	7
Caffeic acid differentially modulates behavior and neurochemicals in chronic unpredictable mild stress and dexamethasone induced models of depression	7
Differential disruption of response alternation by precipitated Δ9-THC withdrawal and subsequent Δ9-THC abstinence in mice	7
Time course of plasticity-related alterations following the first exposure to amphetamine in juvenile rats	7
Context evoked morphine conditioned effects can be equivalent to morphine induced drug effects in terms of behavioral response and ERK activation in reward associated subcortical brain structures	7
Implications of the endocannabinoid system and the therapeutic action of cannabinoids in autism spectrum disorder: A literature review	7
Reinforcing and psychostimulant effects of carfentanil and morphine in mice	7
Unlocking the age-old secrets of reward and substance use	7
The blockade of orexin receptors within the dentate gyrus of the hippocampus attenuated methamphetamine-induced reward learning during conditioning place preference	7
Low dose nicotine administration improves attentional performance in rats but is not blocked by nicotinic antagonists	7
Ligands of the trace amine-associated receptors (TAARs): A new class of anxiolytics	7
Alpha-pyrrolidinopentiothiophenone (α-PVT) activates the TLR–NF-κB–MAPK signaling pathway and proinflammatory cytokine production and induces behavioral sensitization in mice	7
Early adolescent second-generation antipsychotic exposure produces long-term, post-treatment increases in body weight and metabolism-associated gene expression	7
Editorial Board	7
Cocaine diminishes consolidation of cued fear memory in female rats through interactions with ventral hippocampal D2 receptors	7
Editorial Board	7
ERK signaling is required for nicotine-induced conditional place preference by regulating neuroplasticity genes expression in male mice	7
The imidazodiazepine, KRM-II-81: An example of a newly emerging generation of GABAkines for neurological and psychiatric disorders	7
Repeated exposure to ethanol alters memory acquisition and neurotransmission parameters in zebrafish brain	6
Postpartum scarcity-adversity inflicts sex-specific cerebellar adaptations and reward behaviors in adolescence	6
Inbred mouse strain differences in alcohol and nicotine addiction-related phenotypes from adolescence to adulthood	6
The role of reward in substance use disorders: Introduction to the special issue	6
Higher exploratory and vigilant behaviors related to higher central dopaminergic activities of Formosan wood mice (Apodemus semotus) in light-dark exploration tests	6
Combined induction of mTOR-dependent and mTOR-independent pathways of autophagy activation as an experimental therapy for Alzheimer's disease-like pathology in a mouse model	6
Adolescent alcohol exposure modifies adult anxiety-like behavior and amygdala sensitivity to alcohol in rats: Increased c-Fos activity and sex-dependent microRNA-182 expression	6
Role of mGlu receptors in psychiatric disorders – Recent advances	6
Differential patterns of opioid and dopamine D1 receptor antagonism on nutritive and non-nutritive sweetener intakes in C57BL/6:129 hybrid mice relative to inbred C57BL/6 and 129 mice	6
Editorial Board	6
Pentylenetetrazole kindling induces dynamic changes in GAD65 expression in hippocampal somatostatin interneurons	6
Theophylline reverses oxycodone's but not fentanyl's respiratory depression in mice while caffeine is ineffective against both opioids	6
Influence of the dose of ketamine used on schizophrenia-like symptoms in mice: A correlation study with TH, GAD67, and PPAR-γ	6
Differential rearing alters Fos in the accumbens core and ventral palidum following reinstatement of cocaine seeking in male Sprague-Dawley rats	6
Scoping review on environmental enrichment: Are critical periods and sex differences adequately studied?	6
SGK1.1 isoform is involved in nociceptive modulation, offering a protective effect against noxious cold stimulus in a sexually dimorphic manner	6
Kisspeptin-13 induces hyperalgesia and modulates the expression of opioid and glutamate receptors in mice	6
Practical opinions for new fiber photometry users to obtain rigorous recordings and avoid pitfalls	6
Perinatal running training reversed postnatal anxiety and depressive-like behavior and cognitive impairment in mice following prenatal subchronic variable stress	6
Ndufs4 KO mice: A model to study comorbid mood disorders associated with mitochondrial dysfunction	6
Age-related changes in CB1 receptor expression and function and the behavioral effects of cannabinoid receptor ligands	6
Increased alcohol self-administration following repeated Toll-like receptor 3 agonist treatment in male and female rats	6
α7 nicotinic acetylcholine receptors in the medial prefrontal cortex control rewarding but not aversive memory expression in a dopamine-sensitive manner	6
Replication and extension of the subregion selectivity of glutamate-related changes within the nucleus accumbens associated with the incubation of cocaine-craving	6
The piperazine analogue para-fluorophenylpiperazine alters timing of the physiological effects of the synthetic cannabinoid receptor agonist AMB-FUBINACA, without changing its discriminative stimulus,	6
Sex differences in long-term behavioral alterations, especially anxiety, following prenatal fluoxetine exposure in C57BL/6 mice	6
The alpha-7 nicotinic acetylcholine receptor agonist GTS-21 does not affect food intake in rats	6
The antidepressant agomelatine attenuates morphine-induced reinstatement but not self-administration or precipitated withdrawal	6
Swimming exercise reduces the vulnerability to stress and contributes to the AKT/GSK3β/CRMP2 pathway and microtubule dynamics mediated protective effects on neuroplasticity in male C57BL/6 mice	6