OOIR: Observatory of International Research

Papers

(The H4-Index of Drug Metabolism and disPosition is 27. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Characterization of human alcohol dehydrogenase 4 and aldehyde dehydrogenase 2 as enzymes involved in the formation of 5-carboxylpirfenidone, a major metabolite of pirfenidone	83
Human enteroid monolayers: A novel, functionally stable model for investigating oral drug disposition	82
Editorial Board	64
Editorial Board	61
Table of Contents	58
Editorial Board	53
Editorial Board	49
Table of Contents	46
Acetaminophen-Induced Hepatic Necrosis: A Reminiscence	39
Chronic Exposure to E-Cigarettes Elevates CYP2A5 Activity, Protein Expression, and Cotinine-Induced Production of Reactive Oxygen Species in Mice	38
Recommendations on the Use of Multiple Labels in Human Mass Balance Studies	37
Effects of Strong Inhibition of Cytochrome P450 3A and UDP glucuronosyltransferase 1A9 and Strong Induction of Cytochrome P450 3A on the Pharmacokinetics, Safety, and Tolerability of Soticlestat: Two	37
Advances and Challenges in Modeling Cannabidiol Pharmacokinetics and Hepatotoxicity	35
HCV Antiviral Drugs Have the Potential to Adversely Perturb the Fetal-Maternal Communication Axis through Inhibition of CYP3A7 DHEA-S Oxidation	33
Effect of Cimetidine on Metformin Pharmacokinetics and Endogenous Metabolite Levels in Rats	32
Cytochrome P450 Enzymes as Drug Targets in Human Disease	32
Early Prediction and Impact Assessment of CYP3A4-Related Drug-Drug Interactions for Small-Molecule Anticancer Drugs Using Human-CYP3A4-Transgenic Mouse Models	31
Dihydrotanshinone I–Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism	31
Identification and Functional Assessment of Eight CYP3A4 Allelic Variants 39–46 Detected in the Chinese Han Population	30
Radiolabel Uncovers Nonintuitive Metabolites of BIIB104: Novel Release of [14C]Cyanide from 2-Cyanothiophene and Subsequent Formation of [14C]Thiocyanate	30
Pharmacokinetic Effects of Different Models of Nonalcoholic Fatty Liver Disease in Transgenic Humanized OATP1B Mice	29
Assessing Pleiotropic Effects of a Mixed-Mode Perpetrator Drug, Rifampicin, by Multiple Endogenous Biomarkers in Dogs	29
Pharmacokinetic Models Scaled Up from Humanized Liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated and N-Demethylated Metabolites in Pediatric Patients Geno	28
Interaction and Transport of Benzalkonium Chlorides by the Organic Cation and Multidrug and Toxin Extrusion Transporters	28
Identification and Biosynthesis of an N-Glucuronide Metabolite of Camonsertib	28

Age-Dependent Changes in Cytochrome P450 Abundance and Composition in Human Liver	27
Alpibectir: Early Qualitative and Quantitative Metabolic Profiling from a First-Time-in-Human Study by Combining 19F-NMR (Nuclear Magnetic Resonance), 1H-NMR, and High-Resolution Mass Spectrometric An	27