Progress in Biophysics & Molecular Biology

Article	Citations
Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies	72
In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment	57
Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease	50
Bioelectrical approaches to cancer as a problem of the scaling of the cellular self	42
Compressed sensing in fluorescence microscopy	41
Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors	41
Removing striping artifacts in light-sheet fluorescence microscopy: a review	39
ROS-induced cell cycle arrest as a mechanism of resistance in polyaneuploid cancer cells (PACCs)	39
A free energy principle for generic quantum systems	38
Ih from synapses to networks: HCN channel functions and modulation in neurons	35
Localized reconstruction in Scipion expedites the analysis of symmetry mismatches in cryo-EM data	35
The multiple biological roles of the cholinesterases	33
Human coronavirus spike protein-host receptor recognition	32
Towards high-throughput in situ structural biology using electron cryotomography	32
Two-phased evolution: Genome chaos-mediated information creation and maintenance	29
An overview of the vaccine platforms to combat COVID-19 with a focus on the subunit vaccines	29
Mesoscale microscopy and image analysis tools for understanding the brain	27
Mechanosensitive TREK-1 two-pore-domain potassium (K2P) channels in the cardiovascular system	27
The role of stochasticity in biological communication processes	25
Curcumin and cancer; are long non-coding RNAs missing link?	25
What prevents mainstream evolutionists teaching the whole truth about how genomes evolve?	23
The murburn precepts for aerobic respiration and redox homeostasis	23
A systematic review on machine learning and deep learning techniques in cancer survival prediction	23
Computational models of cardiac hypertrophy	21
Treasuring the computational approach in medicinal plant research	21

Roles of ATM and ATR in DNA double strand breaks and replication stress	21
Beyond pacemaking: HCN channels in sinoatrial node function	20
Quantum information theoretic approach to the mind–brain problem	20
Xanthohumol: An underestimated, while potent and promising chemotherapeutic agent in cancer treatment	20
The gene: An appraisal	20
Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease	20
Tools for visualizing and analyzing Fourier space sampling in Cryo-EM	20
Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response	20
Biophysical analysis of an HCN1 epilepsy variant suggests a critical role for S5 helix Met-305 in voltage sensor to pore domain coupling	19
Advances in the understanding of protein misfolding and aggregation through molecular dynamics simulation	19
Living systems approached from physical principles	19
The resolution revolution in X-ray diffraction, Cryo-EM and other Technologies	19
DNA replication stress and emerging prospects for PARG inhibitors in ovarian cancer therapy	18
Fanconi anemia-independent DNA inter-strand crosslink repair in eukaryotes	18
Identification and diagnosis of long COVID-19: A scoping review	17
The role of mechanosensitive Piezo1 channel in diseases	17
Cellular Darwinism: Regulatory networks, stochasticity, and selection in cancer development	17
In vitro cell stretching technology (IsoStretcher) as an approach to unravel Piezo1-mediated cardiac mechanotransduction	17
Biophysical mechanisms underlying the effects of static magnetic fields on biological systems	16
Further insights into the molecular complexity of the human sinus node – The role of ‘novel’ transcription factors and microRNAs	16
Different methods, techniques and their limitations in protein structure prediction: A review	16
Mathematical modelling of the mechano-electric coupling in the human cardiomyocyte electrically connected with fibroblasts	16
Inosine and its methyl derivatives: Occurrence, biogenesis, and function in RNA	16
New role of TRPM4 channel in the cardiac excitation-contraction coupling in response to physiological and pathological hypertrophy in mouse	16
Ca2+ currents in cardiomyocytes: How to improve interpretation of patch clamp data?	16
From leaves to roots: Biophysical models of transport of substances in plants	15
The HCN channel as a pharmacological target: Why, where, and how to block it	15
Action potential alterations induced by single F11 neuronal cell loading	14
Life is a mobius strip	14
The funny current: Even funnier than 40 years ago. Uncanonical expression and roles of HCN/f channels all over the body	14
Reverting to single-cell biology: The predictions of the atavism theory of cancer	14
Making use of noise in biological systems	14
Computational approaches for modeling and structural design of biological systems: A comprehensive review	14
A survey on gene expression data analysis using deep learning methods for cancer diagnosis	14
Structural interpretation of cryo-EM image reconstructions	13
Re-visiting the Frank-Starling nexus	13
What can evolutionary biology learn from cancer biology?	13
Computational techniques for the automated detection of mycobacterium tuberculosis from digitized sputum smear microscopic images: A systematic review	13
Do plants pay attention? A possible phenomenological-empirical approach	13
An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation	13
A revised central dogma for the 21st century: All biology is cognitive information processing	13
The significance of bioelectricity on all levels of organization of an organism. Part 1: From the subcellular level to cells	12
Biology transcends the limits of computation	12
Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM	12
The role of viscoelasticity in long time cell rearrangement	12
Cellular and organismal agency – Not based on genes: A comment on Baverstock	12
An overview of the biological effects of extremely low frequency electromagnetic fields combined with ionizing radiation	12
Insulin fibrillation: Strategies for inhibition	12
The living state: How cellular excitability is controlled by the thermodynamic state of the membrane	12
Do the functional properties of HCN1 mutants correlate with the clinical features in epileptic patients?	12

State-dependent sequential allostery exhibited by chaperonin TRiC/CCT revealed by network analysis of Cryo-EM maps	12
The somatic molecular evolution of cancer: Mutation, selection, and epistasis	12
Atomic force microscopy (AFM) and its applications to bone-related research	12
The biological effects of radiation-induced liver damage and its natural protective medicine	12
Evidence of the static magnetic field effects on bone-related diseases and bone cells	11
Exosomes in bone remodeling and breast cancer bone metastasis	11
The thermodynamic soliton theory of the nervous impulse and possible medical implications	11
Biological effects of rotating magnetic field: A review from 1969 to 2021	11
Efficient metadata mining of web-accessible neural morphologies	11
Roles of ATM and ATR in DNA double strand breaks and replication stress	11
Autonomic modulation of sinoatrial node: Role of pacemaker current and calcium sensitive adenylyl cyclase isoforms	11
High resolution single particle Cryo-EM refinement using JSPR	11
Integration of mechanics and biology in computer simulation of bone remodeling	11
Optical clearing in cardiac imaging: A comparative study	11
Glycometabolism reprogramming: Implications for cardiovascular diseases	11
The important consequences of the reversible heat production in nerves and the adiabaticity of the action potential	11
HCN4 current during human sinoatrial node-like action potentials	11
Growth or death? Control of cell destiny by mTOR and autophagy pathways	10
Clustering polymorphs of tau and IAPP fibrils with the CHEP algorithm	10
Proteostasis impairment and ALS	10
The role of non-coding genome in the behavior of infiltrated myeloid-derived suppressor cells in tumor microenvironment; a perspective and state-of-the-art in cancer targeted therapy	10
The impact of low intensity ultrasound on cells: Underlying mechanisms and current status	10
DNA glycosylase NEIL2 functions in multiple cellular processes	10
Ionic channels in nerve membranes, 50 years on	10
The cancer puzzle: Welcome to organicism	10
Current density as routine parameter for description of ionic membrane current: is it always the best option?	10
Targeting cell-matrix interface mechanobiology by integrating AFM with fluorescence microscopy	10
Neo-Darwinism must Mutate to survive	10
Sound pulses in lipid membranes and their potential function in biology	10
The Importance of Henry H. Heng's Genome Architecture Theory	10
The epigenetic basis of evolution	10
Colon cancer transcriptome	9
Exploring the human cerebral cortex using confocal microscopy	9
The surprising heart revisited: an early history of the funny current with modern lessons	9
Distribution of data in cellular electrophysiology: Is it always normal?	9
Consciousness, embodied Quantum Entanglement	9
Structural basis of the (in)activity of the apical DNA damage response kinases ATM, ATR and DNA-PKcs	9
Cellular metabolism and colloids: Realistically linking physiology and biological physical chemistry	8
Machine learning approaches in diagnosing tuberculosis through biomarkers - A systematic review	8
Autophagy and kidney aging	8
From traditional medicine to modern oncology: Scutellarin, a promising natural compound in cancer treatment	8
Stages, scaffolds and strings in the spatial organisation of non-homologous end joining: Insights from X-ray diffraction and Cryo-EM	8
Long non-coding RNAs (lncRNAs) in hepatocellular carcinoma progression: Biological functions and new therapeutic targets	8
It's clearly the heart! Optical transparency, cardiac tissue imaging, and computer modelling	8
Abiotic stress elements in in vitro potato (Solanum tuberosum L.) exposed to air-based and liquid-based ultrasound: A comparative transcriptomic assessment	8
Coronavirus disease 2019 (COVID-19): Biophysical and biochemical aspects of SARS-CoV-2 and general characteristics	8
The effect of magnetic fields on tumor occurrence and progression: Recent advances	8
Further illusions: On key evolutionary mechanisms that could never fit with Modern Synthesis	8
Innovations in ex vivo Light Sheet Fluorescence Microscopy	8
Cryo-EM reveals infection steps of single-stranded RNA bacteriophages	8
Intercellular communication through extracellular vesicles in cancer and evolutionary biology	7
MicroRNAs: New contributors to mechano-electric coupling and atrial fibrillation	7
TRPV2 channel-based therapies in the cardiovascular field. Molecular underpinnings of clinically relevant therapies	7
Infrared neural stimulation at different wavelengths and pulse shapes	7
Optical studies of membrane state during action potential propagation	7
HCN1 channels: A versatile tool for signal processing by primary sensory neurons	7
The funny current in genetically modified mice	7
Cyclic nucleotide signaling and pacemaker activity	7
Origin of life: Drawing the big picture	7
Cancer as a form of life: Musings of the cancer and evolution symposium	7
Constrained disorder principle-based variability is fundamental for biological processes: Beyond biological relativity and physiological regulatory networks	6
The flexible and iterative steps within the NHEJ pathway	6
The problem of accuracy in single-channel open probability measurements	6
Expansion light sheet fluorescence microscopy of extended biological samples: Applications and perspectives	6
The evolution of evolutionary processes in organismal and cancer evolution	6
Decrypting the mechanistic basis of CRISPR/Cas9 protein	6
Cellular evolution of language	6
The genetic control paradigm in biology: What we say, and what we are entitled to mean	6
Static magnetic field: A potential tool of controlling stem cells fates for stem cell therapy in osteoporosis	6
Transcriptional signatures regulated by TRPC1/C4-mediated Background Ca2+ entry after pressure-overload induced cardiac remodelling	6
An overview of the intracellular localization of high-Z nanoradiosensitizers	6
A review of regulated self-organizing approaches for tissue regeneration	6
Clinical significance of circulating tumor cell (CTC)-specific microRNA (miRNA) in breast cancer	6
Genes and knowledge: Response to Baverstock, K. the gene an appraisal. https://doi.org/10.1016/j.pbiomolbio.2021.04.005	5
The value of treating cancer as an evolutionary disease	5
Pacemaker activity and ion channels in the sinoatrial node cells: MicroRNAs and arrhythmia	5
Recent advancements to engineer mesenchymal stem cells and their extracellular vesicles for targeting and destroying tumors	5
Biological autoluminescence as a perturbance-free method for monitoring oxidation in biosystems	5
The origin of the heartbeat and theories of muscle contraction. Physiological concepts and conflicts in the 19th century	5
Accuracy considerations for capacitance estimation by voltage steps in cardiomyocytes	5

A systematic review on intracranial aneurysm and hemorrhage detection using machine learning and deep learning techniques	5
A survey of pathways for mechano-electric coupling in the atria	5
Advances in the synthesis and application of self-assembling biomaterials	5
Temporal irregularity quantification and mapping of optical action potentials using wave morphology similarity	5
Time delay during the proton tunneling in the base pairs of the DNA double helix	5
FTIR based approach to study EnaC mechanosensory functions	5
Advances in surface-enhanced Raman spectroscopy-based sensors for detection of various biomarkers	5
TUDCA receptors and their role on pancreatic beta cells	5
Regulation of sinoatrial funny channels by cyclic nucleotides: From adrenaline and IK2 to direct binding of ligands to protein subunits	4
An update on ATP synthase inhibitors: A unique target for drug development in M. tuberculosis	4
A systematic review of artificial intelligence-based COVID-19 modeling on multimodal genetic information	4
Smartphone-based diagnostics for biosensing infectious human pathogens	4
FOXI1 inhibits gastric cancer cell proliferation by activating miR-590/ATF3 axis via integrating ChIP-seq and RNA-seq data	4
The virtual sinoatrial node: What did computational models tell us about cardiac pacemaking?	4
Development as explanation: Understanding phenotypic stability and variability after the failure of genetic determinism	4
A special role for the genotype? Some comments on Keith Baverstock: “The gene: An appraisal”	4
Siglec-15 as multifunctional molecule involved in osteoclast differentiation, cancer immunity and microbial infection	4
The Physics–Biology continuum challenges darwinism: Evolution is directed by the homeostasis-dependent bidirectional relation between genome and phenotype	4
lncRNA-mediated synovitis in rheumatoid arthritis: A perspective for biomarker development	4
Thermodynamic inconsistency disproves the Suga-Sagawa theory of cardiac energetics	4
Exploring different computational approaches for effective diagnosis of breast cancer	4
An overview of polymer surface coated synthetic quantum dots as therapeutics and sensors applications	4
A review: Exploring the metabolic and structural characterisation of beta pleated amyloid fibril in human tissue using Raman spectrometry and SAXS	4
Something’s gotta give: How PCNA alters its structure in response to mutations and the implications on cellular processes	4
“Thermoeconomics”: Time to move beyond the second law	4
Implication of frequency-dependent protocols in antiarrhythmic and proarrhythmic drug testing	4
The dynamic nature of the Mre11-Rad50 DNA break repair complex	4
A common pathway to cancer: Oncogenic mutations abolish p53 oscillations	4
Systems biology of human aging: A Fibonacci time series model	4