OOIR: Observatory of International Research

Papers

(The median citation count of Memorias do Instituto Oswaldo Cruz is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress	50
Insecticide resistance levels and associated mechanisms in three Aedes aegypti populations from Venezuela	32
First concrete documentation for presence of Aedes (Stegomyia) albopictus in Bolivia: dispelling previous anecdotes	28
Sublingual microcirculatory alterations in Chagas disease: an observational study in an endemic rural population	24
PPE59 antibodies in tuberculous patients and potential use for diagnosis when assayed with other rapid biomarkers	23
Genomic surveillance: a potential shortcut for effective Chagas disease management	21
Impact of dengue virus infection on the cytoadherence of Plasmodium vivax-infected erythrocytes	20
Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress	17
Memórias do Instituto Oswaldo Cruz celebrates 115 years of scientific publishing: what it needs to keep moving on…	17
How people affected by Chagas disease have struggled with their negligence: history, associative movement and World Chagas Disease Day	15
Pharmacokinetics of two pharmaceutical presentations of benznidazole in adult Trypanosoma cruzi infected population	15
Why do we still have not a vaccine against Chagas disease?	14
Plants of the family Lamiaceae as a source of therapeutic agents against Acanthamoeba infections	13
Revisiting Chagas' disease diagnostic strategies in light of different scenarios of Trypanosoma cruzi infection	13
Improving in vitro screening compounds anti-Trypanosoma cruzi by GFP-expressing parasites	11
Significance of a neglected tropical disease: lessons from a paradigmatic case of ‘success in translation’	10
Intravenous whole blood transfusion results in faster recovery of vascular integrity and increased survival in experimental cerebral malaria	10
The multidimensional comprehension of Chagas disease. Contributions, approaches, challenges and opportunities from and beyond the Information, Education and Communication field	10
Trypanosoma cruzi and Chagas disease: diversity, progress and challenges	10
Transforming growth factor-ß as a therapeutic target for the cardiac damage of Chagas disease	9
In vitro activity of Schinus terebinthifolius extract and fractions against Sporothrix brasiliensis	9
Characterisation of Neisseria meningitidis cc11/ET-15 variant by whole genome sequencing	9
Perillyl alcohol modulates activation, permeability and integrity of human brain endothelial cells induced by Plasmodium falciparum	8
125 years of the plague in Brazil: lessons learnt, historical insights and contemporary challenges	8
Surveillance of land molluscs infected by Angiostrongylus cantonensis (Nematoda) reveals risk areas for zoonotic eosinophilic meningitis in the State of Rio de Janeiro, Brazil	8

Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy	7
Iron and vitamin D intake on a diet are able to modify the in vitro immune response to Mycobacterium leprae	7
A review of serological tests available in Brazil for intestinal schistosomiasis diagnosis	7
Leishmania (Leishmania) infantum DNA detection in Nyssomyia neivai in Vale do Ribeira, Paraná, Brazil	7
Heterochromatin protein 1 (HP1) of Schistosoma mansoni: non-canonical chromatin landscape and oviposition effects	6
Cross-sectional entomological monitoring combined with professional qualifications in transition areas for yellow fever and autochthonous malaria in the Atlantic Forest in Rio de Janeiro, Brazil	6
Diphtheria antitoxin treatment: from pioneer to neglected	6
Congenital Zika virus infection in laboratory animals: a comparative review highlights translational studies on the maternal-foetal interface	6
Polyunsaturated fatty acids alter the formation of lipid droplets and eicosanoid production in Leishmania promastigotes	6
Heavy metal resistance in the Yanomami and Tunapuco microbiome	5
Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: mitochondrion as a strategic target	5
Evaluation of the influence of genetic variants in Cereblon gene on the response to the treatment of erythema nodosum leprosum with thalidomide	5
Aedes aegypti reproductive aspects: constant light significantly affects the embryonic development	4
Pathophysiology and new targets for therapeutic options in Chagas heart disease	4
Chagas disease in the context of the 2030 agenda: global warming and vectors	4
Unique synapomorphies and high diversity in South American Raji-related Epstein-Barr virus genomes	4
Challenges and perspectives in research and teaching of host pathogen interaction topics: new post-pandemic times to Brazil and other South American countries	4
Reflections on Chagas disease in the Amazon	4
New possibilities for chromoblastomycosis and phaeohyphomycosis treatment: identification of two compounds from the MMV Pathogen Box® that present synergism with itraconazole	4
First report of Leishmania RNA virus 1 in Leishmania (Viannia) braziliensis clinical isolates from Rio de Janeiro State - Brazil	4
Translational research in Chagas disease: perspectives in nutritional therapy emerging from selenium supplementation studies as a complementary treatment	4
Peeking into the mysterious world of Trypanosoma cruzi and Chagas disease	4
Investigating the distribution of a rare Colombo-Venezuelan kissing bug, Rhodnius neivai, Lent, 1953, using geographical information system-based analyses	4
Increased angiogenesis parallels cardiac tissue remodelling in experimental acute Trypanosoma cruzi infection	4
Clinical and epidemiological aspects of Delta and Gamma SARS-CoV-2 variant of concern from the western Brazilian Amazon	4
Host cholesterol influences the activity of sterol biosynthesis inhibitors in Leishmania amazonensis	4
Binding of the extracellular matrix laminin-1 to Clostridioides difficile strains	4
Exploring BCG to deliver avidin fusion antigens from Schistosoma mansoni	4
The risk of vector transmission of Trypanosoma cruzi remains high in the State of Paraná	3
Microbiome and virome on indoor surfaces of an Antarctic research ship	3
Critical analysis of Chagas disease treatment in different countries	3
Different profiles of chemokines, cytokines and cell growth factors in plasma samples from patients with leprosy, leprosy reactions and households contacts	3
Waiting for a success story in prevention, control and treatment of Chagas disease in non-endemic countries	3
Chikungunya virus infection in the southernmost state of Brazil was characterised by self-limited transmission (2017-2019) and a larger 2021 outbreak	3
The translational challenge in Chagas disease drug development	3
Cerebrospinal fluid: a target of some fungi and an overview	3
Accuracy of rapid point-of-care serological tests for leprosy diagnosis: a systematic review and meta-analysis	3
A newly bat-borne hantavirus detected in Seba’s short-tailed bats (Carollia perspicillata) in the Brazilian Atlantic Rainforest	3
Long COVID-19 syndrome associated with Omicron XBB.1.5 infection: a case report	3
Chagas disease (American trypanosomiasis) in the context of the 2030 agenda. Insights into global warming and vector control	2
Genetic diversity of Trypanosoma cruzi strains isolated from chronic chagasic patients and non-human hosts in the state of São Paulo, Brazil	2
From the first descriptions to recent advances: 115 years of reptile Plasmodium research in the Neotropics	2
Leptospira interrogans insoluble fraction as a potential antigen source for lateral flow immunochromatography	2
Prognosis of chronic Chagas heart disease and other pending clinical challenges	2
COVID-19 outbreaks among crew members in non-cruise vessels anchoring in Salvador, Brazil, 2021	2
Analysis of a novel class A β-lactamase OKP-B-6 of Klebsiella quasipneumoniae: structural characterisation and interaction with commercially available drugs	2
Impact of gut-peripheral nervous system axis on the development of diabetic neuropathy	2
Multiplex PCR assays developed for neglected pathogen detection in undifferentiated acute febrile illness cases in tropical regions	2
Lack of serological and molecular evidences of Zika virus circulation in non-human primates in three states from Brazil	2
A short history of innate immunity	2

Traditional use of benznidazole with weekly clinical follow-up indicate to be an important approach for the etiologic treatment of Chagas disease	2
Benznidazole treatment decreases IL-6 levels in Trypanosoma cruzi-infected human adipocytes differentiated from adipose tissue-derived stem cells	2
Electrochemical immunosensor for detection of Plasmodium vivax lactate dehydrogenase	2
Chagas disease and mobility: comments on the challenges for access and the right to health for migrants	2
Population size regulation is density-dependent in Rhodnius prolixus (Hemiptera: Reduviidae) through an irritability mechanism	2
Chagas disease treatment: a 120-year-old challenge to public health	2
Leukocyte telomere length and telomerase activity in Long COVID patients from Rio de Janeiro, Brazil	1
Endocytosis in anaerobic parasitic protists	1
Mapping special areas of the Brazilian National Malaria Control Program in the Amazon region: a territorial-based approach to surveillance	1
Influence of killer immunoglobulin-like receptors genes on the recurrence rate of ocular toxoplasmosis in Brazil	1
Computational approaches towards the discovery and optimisation of cruzain inhibitors	1
Challenges for fighting Chagas disease in the 21st century	1
Molecular diversity of genes related to biological rhythms (period and timeless) and insecticide resistance (Na V and ace-1) in Anopheles darlingi	1
Giardia lamblia-infected preschoolers present growth delays independent of the assemblage A, B or E	1
Ongoing HIV-1 evolution and reservoir reseeding in two elite controllers with genetically diverse peripheral proviral quasispecies	1
Exploring the performance of Escherichia coli outer membrane vesicles as a tool for vaccine development against Chagas disease	1
Acute Chagas disease in Amazonia, western Pará: perspectives from medical assistance to genetic elucidation	1
Climate change-induced degradation of expert range maps drawn for kissing bugs (Hemiptera: Reduviidae) and long-standing current and future sampling gaps across the Americas	1
Looking for approved-medicines to be repositioned as anti-Trypanosoma cruzi agents. Identification of new chemotypes with good individual- or in combination-biological behaviours	1
Leishmania (Sauroleishmania) tarentolae versus pathogenic species: comparative evaluation of protease activity, glycoconjugates, resistance to complement and metabolome composition	1
HIV-1 controllers exhibit an enhanced antiretroviral innate state characterised by overexpression of p21 and MCPIP1 and silencing of ERVK-6 RNA expression	1
Mitochondrial dysfunction on Leishmania (Leishmania) amazonensis induced by ketoconazole: insights into drug mode of action	1
Mapping Yellow fever epidemics as a potential indicator of the historical range of Aedes aegypti in the United States	1
Association of CD209 (DC-SIGN) rs735240 SNV with paucibacillary leprosy in the Brazilian population and its functional effects	1
Vitellogenin genes are transcribed in Culex quinquefasciatus ovary	1
Characterization of larval habitats of Anopheles (Nyssorhynchus) darlingi and associated species in malaria areas in western Brazilian Amazon	1
Simple and promising paper-based electrochemical platform for serological detection of American tegumentary leishmaniasis	1
Chagas disease affects the human placental barrier’s turnover dynamics during pregnancy	1
The achievement of a storytelling about Chagas disease: how to talk about silence; how to visualise the invisible	1
Molecular mechanisms of action of trypanocidal and leishmanicidal drugs with focus on novel chemotherapeutic strategies: creation of a Brazilian multicentre working group	1
The challenge of risk assessment in the riddle of Chagas heart disease	1
Effect of temperature on the activity of efflux pumps in selected species of human opportunistic bacterial pathogens	1
Population movements, borders, and Chagas disease	1
How is global change affecting Chagas disease landscapes?	1
Matrix-assisted laser desorption/ionisation-time of flight mass spectrometry azole susceptibility assessment in Candida and Aspergillus species	1
The challenges for targeting Chagas disease for elimination as a public health problem	1
Reflections, suggestions for putting into practice the principles of information, education and communication - IEC on Chagas disease in a community context	1
Non-cerebral malaria: does such a thing exist?	1
Differences in responses to the intracellular macrophage environment between Mycobacterium bovis BCG vaccine strains Moreau and Pasteur	1
Free-living amoebae: a journey into historical aspects and to current discoveries	1
The Oxente Chagas Bahia Project: evaluating the efficacy of a rapid diagnostic test and treatments for Chagas disease	1
Unveiling the genome of a high-risk pandrug-resistant Klebsiella pneumoniae emerging in the Brazilian Amazon Region, 2022	1
The history of Chagas disease: reflections on science in action	1
Worldwide distribution, symptoms and diagnosis of the coinfections between malaria and arboviral diseases: a systematic review	1
Epoxy-a-lapachone in nanosystem: a prototype drug for leishmaniasis assessed in the binomial BALB/c - Leishmania (Leishmania) amazonensis	1
Antileishmanial effects of γCdcPLI, a phospholipase A2 inhibitor from Crotalus durissus collilineatus snake serum, on Leishmania (Leishmania) amazonensis	1
The absence of eosinophils is associated with early metastatic lesions in Leishmania amazonensis-infected mice	1
Chagas disease challenge - New techniques for diagnosis and treatment address to control in endemic areas	1
Pandemic ST131 Escherichia coli presenting the UPEC/EAEC and ExPEC/EAEC hybrid pathotypes recovered from extraintestinal infections in a clinical setting of the Brazilian Amazon region	1
Repositioning drug strategy against Trypanosoma cruzi: lessons learned from HIV aspartyl peptidase inhibitors	1
Different profiles and epidemiological scenarios: past, present and future	1
Vibrio cholerae and Vibrio paracholerae bacteraemia strains encompass lineages that share resistome and virulome profiles	1
Trypanosoma cruzi genetic diversity: impact on transmission cycles and Chagas disease	1
Toxoplasma gondii in the faeces of wild felids from the Atlantic Forest, Brazil	1
First report of putative Leishmania RNA virus 2 (LRV2) in Leishmania infantum strains from canine and human visceral leishmaniasis cases in the southeast of Brazil	1
Design of a specific peptide against phenolic glycolipid-1 from Mycobacterium leprae and its implications in leprosy bacilli entry	1
First report and genome sequencing of SARS-CoV-2 in a cat (Felis catus) in Colombia	1
Silent dissemination of HTLV-1: evidence of intrafamilial transmission in a Brazilian reference centre	1
Prevalence and force of Plasmodium vivax blood-stage infection and associated clinical malaria burden in the Brazilian Amazon	1
Molecular detection of omicron SARS-CoV-2 variant is achieved by RT-LAMP despite genomic mutations	1
Homozygotes NAT2*5B slow acetylators are highly associated with hepatotoxicity induced by anti-tuberculosis drugs	1