OOIR: Observatory of International Research

Papers

(The TQCC of Essays in Biochemistry is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
CRISPR screening in cancer stem cells	141
How viral proteins bind short linear motifs and intrinsically disordered domains	136
CaMKK2: bridging the gap between Ca2+ signaling and energy-sensing	118
Phase separation of the microtubule-associated protein tau	115
Butyrate-producing colonic clostridia: picky glycan utilization specialists	79
Salicylic acid and jasmonic acid crosstalk in plant immunity	61
DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling	54
The role of methionine synthases in fungal metabolism and virulence	53
Apoplastic and vascular defences	51
Can changes in 3D genome architecture create new regulatory landscapes that contribute to phenotypic evolution?	50
The dual role of the ubiquitin–proteasome system in photomorphogenesis	49
Malate dehydrogenase: a story of diverse evolutionary radiation	46
Perspective on pros and cons of microlearning in health education	45
Astrocytes in memory formation and maintenance	44
A special issue of Essays in Biochemistry on evolutionary developmental biology	43
O-Mucin-degrading carbohydrate-active enzymes and their possible implication in inflammatory bowel diseases	43
Plant peroxisome proteostasis—establishing, renovating, and dismantling the peroxisomal proteome	43
Branched-chain amino acid biosynthesis in fungi	43
The cGAS-STING pathway in cancer immunity: dual roles, therapeutic strategies, and clinical challenges	42
Mass spectrometric insights into protein aggregation	40
Functional amyloid in a lipid-like environment: a merry dance of many steps	39
Prostate cancer as a dedifferentiated organ: androgen receptor, cancer stem cells, and cancer stemness	37
Hemicellulolytic enzymes in lignocellulose processing	37
Systemic acquired resistance-associated transport and metabolic regulation of salicylic acid and glycerol-3-phosphate	36
Shapeshifting proteins: the role of structural disorder and conformational plasticity in physiology and disease	36

Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling	33
Modulating immune cells within pancreatic ductal adenocarcinoma via nanomedicine	33
Harnessing extremophilic carboxylesterases for applications in polyester depolymerisation and plastic waste recycling	33
Phase separation and other forms of α-Synuclein self-assemblies	32
Nitrification in acidic and alkaline environments	32
Lipids and the cancer stemness regulatory system in acute myeloid leukemia	30
RNA-binding protein dysfunction in neurodegeneration	29
Regulation of R-loops by nucleic acid and protein modifications	29
Insight into the structure and molecular mode of action of plant paired NLR immune receptors	28
The molecular basis of cereal grain proteostasis	27
Long non-coding RNA and ribosomal protein genes in a yeast ageing model: an investigation for undergraduate research-based learning	25
Plant proteostasis: a proven and promising target for crop improvement	25
The road less travelled? Exploring the nuanced evolutionary consequences of duplicated genes	25
Membrane lipid raft homeostasis is directly linked to neurodegeneration	25
Vesicular dysfunction and pathways to neurodegeneration	24
Astrocyte heterogeneity and interactions with local neural circuits	23
UFM1 at the endoplasmic reticulum: linking ER stress, ribosome quality control, and ER-phagy	23
Oxidative stress – Alzheimer’s disease – DNA methylation: the role of arsenic	22
Evolution of resistance (R) gene specificity	22
Harnessing neutrophil plasticity for HCC immunotherapy	22
Astroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?	22
Acetylation, ADP-ribosylation and methylation of malate dehydrogenase	21
Crossroads between copper ions and amyloid formation in Parkinson’s disease	21
Evo-devo perspectives on cancer	21
The new age of the phage	20
Sulfate: a neglected (but potentially highly relevant) anion	20
Mitochondrial Ca2+ handling as a cell signaling hub: lessons from astrocyte function	20
Malate dehydrogenase (MDH) in cancer: a promiscuous enzyme, a redox regulator, and a metabolic co-conspirator	20
The COP9 signalosome variants CSNCSN7A and CSNCSN7B form complexes with specific CRLs which are targets of autophagy	19
The role of the Mediator complex in fungal pathogenesis and response to antifungal agents	19
WNT signaling and cancer stemness	19
Molecular divergence with major morphological consequences: development and evolution of organ size and shape	19
Insights into the regulation of malate dehydrogenase: inhibitors, activators, and allosteric modulation by small molecules	19
Shaping Hox gene activity to generate morphological diversity across vertebrate phylogeny	19
How phosphorylation impacts intrinsically disordered proteins and their function	19
Quantification of persulfidation on specific proteins: are we nearly there yet?	18
Immunotherapy for hypertensive end-organ damage: a new therapeutic strategy	17
Using epigenetic clocks in environmental epigenetics: recommendations for estimating biological aging in perinatal and pediatric samples	17
Immunologically relevant effects of radiation therapy on the tumor microenvironment	17
The interplay between lytic polysaccharide monooxygenases and glycoside hydrolases	17
Evolution and functional diversification of yeast sugar transporters	16
Emerging strategies in lymph node-targeted nano-delivery systems for tumor immunotherapy	16
Specificity and diversity of Klebsiella pneumoniae phage-encoded capsule depolymerases	16
Chemical approaches to the sulfation of small molecules: current progress and future directions	16
Direct recognition of pathogen effectors by plant NLR immune receptors and downstream signalling	16
Molecular plant immunity against biotrophic, hemibiotrophic, and necrotrophic fungi	16