OOIR: Observatory of International Research

Papers

(The TQCC of Essays in Biochemistry is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
CRISPR screening in cancer stem cells	200
How viral proteins bind short linear motifs and intrinsically disordered domains	162
Phase separation of the microtubule-associated protein tau	159
Heterologous expression of NRPS and PKS pathways in Escherichia coli : from bottlenecks to biosynthetic platforms	115
CaMKK2: bridging the gap between Ca2+ signaling and energy-sensing	85
Inter-species horizontal transfer of biosynthetic gene clusters: an evolutionary driver for chemical diversity in bacterial communities	85
Salicylic acid and jasmonic acid crosstalk in plant immunity	83
Butyrate-producing colonic clostridia: picky glycan utilization specialists	73
The role of methionine synthases in fungal metabolism and virulence	71
The dual role of the ubiquitin–proteasome system in photomorphogenesis	69
Astrocytes in memory formation and maintenance	68
Expanding perspectives on specialized metabolism in Streptomyces bacteria	63
Apoplastic and vascular defences	58
Bacterial–fungal interactions: connections and consequences	58
Can changes in 3D genome architecture create new regulatory landscapes that contribute to phenotypic evolution?	55
Versatile roles of inositol hexakisphosphate in the ubiquitin-proteasome system	54
DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling	52
Malate dehydrogenase: a story of diverse evolutionary radiation	52
Mass spectrometric insights into protein aggregation	51
A special issue of Essays in Biochemistry on evolutionary developmental biology	51
Translating biosynthetic gene cluster architecture into biosensor design for microbial natural product discovery	51
The cGAS-STING pathway in cancer immunity: dual roles, therapeutic strategies, and clinical challenges	51
O-Mucin-degrading carbohydrate-active enzymes and their possible implication in inflammatory bowel diseases	51
Colony politics to chemical warfare: phenotypic plasticity in Streptomyces	47
Intra- and inter-biosynthetic gene cluster allelic variation as drivers of chemical diversification in Streptomyces	46

Functional amyloid in a lipid-like environment: a merry dance of many steps	44
Branched-chain amino acid biosynthesis in fungi	44
Shapeshifting proteins: the role of structural disorder and conformational plasticity in physiology and disease	44
Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling	43
Hemicellulolytic enzymes in lignocellulose processing	40
Harnessing extremophilic carboxylesterases for applications in polyester depolymerisation and plastic waste recycling	40
Modulating immune cells within pancreatic ductal adenocarcinoma via nanomedicine	39
Nitrification in acidic and alkaline environments	36
Prostate cancer as a dedifferentiated organ: androgen receptor, cancer stem cells, and cancer stemness	35
Imaging of biofilms using cryo-scanning electron microscopy	34
The molecular basis of cereal grain proteostasis	31
Mesolens imaging in microbiology	31
Systemic acquired resistance-associated transport and metabolic regulation of salicylic acid and glycerol-3-phosphate	31
Phase separation and other forms of α-Synuclein self-assemblies	30
Lipids and the cancer stemness regulatory system in acute myeloid leukemia	30
Regulation of R-loops by nucleic acid and protein modifications	30
The enabling power of chemical probes: examples from the nuclear hormone receptor field	29
Insight into the structure and molecular mode of action of plant paired NLR immune receptors	29
The road less travelled? Exploring the nuanced evolutionary consequences of duplicated genes	29
Long non-coding RNA and ribosomal protein genes in a yeast ageing model: an investigation for undergraduate research-based learning	28
NEDD8, stress granules, and amyotrophic lateral sclerosis: unveiling the therapeutic potential of the NEDP1 protease	27
Plant proteostasis: a proven and promising target for crop improvement	27
Astroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?	26
Developing physical seed priming as a practical tool for stress-resilient crop production	26
Oxidative stress – Alzheimer’s disease – DNA methylation: the role of arsenic	25
Evolution of resistance (R) gene specificity	25
Harnessing neutrophil plasticity for HCC immunotherapy	24
The new age of the phage	24
UFM1 at the endoplasmic reticulum: linking ER stress, ribosome quality control, and ER-phagy	24
Astrocyte heterogeneity and interactions with local neural circuits	24
Crossroads between copper ions and amyloid formation in Parkinson’s disease	24
Reactive oxygen species and oxidative signalling in plants	22
Sulfate: a neglected (but potentially highly relevant) anion	22
Epigenetics and chemical exposures	22
Evo-devo perspectives on cancer	22
Acetylation, ADP-ribosylation and methylation of malate dehydrogenase	22
Mitochondrial Ca2+ handling as a cell signaling hub: lessons from astrocyte function	21
WNT signaling and cancer stemness	21
When, where, and why specialised metabolites are produced: inferring function from expression control	21
Insights into the regulation of malate dehydrogenase: inhibitors, activators, and allosteric modulation by small molecules	21
Malate dehydrogenase (MDH) in cancer: a promiscuous enzyme, a redox regulator, and a metabolic co-conspirator	21
Immunotherapy for hypertensive end-organ damage: a new therapeutic strategy	20
Quantification of persulfidation on specific proteins: are we nearly there yet?	20
The COP9 signalosome variants CSNCSN7A and CSNCSN7B form complexes with specific CRLs which are targets of autophagy	20
Shaping Hox gene activity to generate morphological diversity across vertebrate phylogeny	20
A guide to Direct Pathway Cloning (DiPaC) for natural product discovery	20
How phosphorylation impacts intrinsically disordered proteins and their function	20
Immunologically relevant effects of radiation therapy on the tumor microenvironment	19
The interplay between lytic polysaccharide monooxygenases and glycoside hydrolases	19
Molecular divergence with major morphological consequences: development and evolution of organ size and shape	19

Direct recognition of pathogen effectors by plant NLR immune receptors and downstream signalling	19
Using epigenetic clocks in environmental epigenetics: recommendations for estimating biological aging in perinatal and pediatric samples	19
The role of the Mediator complex in fungal pathogenesis and response to antifungal agents	19
It takes a village: how plant-associated bacterial communities socialise to shape plant growth and health	19