OOIR: Observatory of International Research

Papers

(The median citation count of Essays in Biochemistry is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
CRISPR screening in cancer stem cells	178
How viral proteins bind short linear motifs and intrinsically disordered domains	146
Inter-species horizontal transfer of biosynthetic gene clusters: an evolutionary driver for chemical diversity in bacterial communities	142
Salicylic acid and jasmonic acid crosstalk in plant immunity	101
Butyrate-producing colonic clostridia: picky glycan utilization specialists	71
Phase separation of the microtubule-associated protein tau	68
CaMKK2: bridging the gap between Ca2+ signaling and energy-sensing	66
The role of methionine synthases in fungal metabolism and virulence	63
Can changes in 3D genome architecture create new regulatory landscapes that contribute to phenotypic evolution?	61
Astrocytes in memory formation and maintenance	61
Malate dehydrogenase: a story of diverse evolutionary radiation	60
Versatile roles of inositol hexakisphosphate in the ubiquitin-proteasome system	59
DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling	55
Apoplastic and vascular defences	53
The dual role of the ubiquitin–proteasome system in photomorphogenesis	51
Plant peroxisome proteostasis—establishing, renovating, and dismantling the peroxisomal proteome	50
A special issue of Essays in Biochemistry on evolutionary developmental biology	49
Mass spectrometric insights into protein aggregation	48
Branched-chain amino acid biosynthesis in fungi	47
O-Mucin-degrading carbohydrate-active enzymes and their possible implication in inflammatory bowel diseases	47
Harnessing extremophilic carboxylesterases for applications in polyester depolymerisation and plastic waste recycling	46
Shapeshifting proteins: the role of structural disorder and conformational plasticity in physiology and disease	46
The cGAS-STING pathway in cancer immunity: dual roles, therapeutic strategies, and clinical challenges	46
Functional amyloid in a lipid-like environment: a merry dance of many steps	45
Modulating immune cells within pancreatic ductal adenocarcinoma via nanomedicine	40

Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling	39
Prostate cancer as a dedifferentiated organ: androgen receptor, cancer stem cells, and cancer stemness	39
Systemic acquired resistance-associated transport and metabolic regulation of salicylic acid and glycerol-3-phosphate	38
Hemicellulolytic enzymes in lignocellulose processing	38
Nitrification in acidic and alkaline environments	38
Phase separation and other forms of α-Synuclein self-assemblies	35
Regulation of R-loops by nucleic acid and protein modifications	32
Lipids and the cancer stemness regulatory system in acute myeloid leukemia	32
Insight into the structure and molecular mode of action of plant paired NLR immune receptors	32
Long non-coding RNA and ribosomal protein genes in a yeast ageing model: an investigation for undergraduate research-based learning	29
The road less travelled? Exploring the nuanced evolutionary consequences of duplicated genes	29
The molecular basis of cereal grain proteostasis	29
Astroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?	28
Plant proteostasis: a proven and promising target for crop improvement	28
NEDD8, stress granules, and amyotrophic lateral sclerosis: unveiling the therapeutic potential of the NEDP1 protease	28
Evolution of resistance (R) gene specificity	26
UFM1 at the endoplasmic reticulum: linking ER stress, ribosome quality control, and ER-phagy	26
Oxidative stress – Alzheimer’s disease – DNA methylation: the role of arsenic	25
Harnessing neutrophil plasticity for HCC immunotherapy	25
Astrocyte heterogeneity and interactions with local neural circuits	25
Acetylation, ADP-ribosylation and methylation of malate dehydrogenase	24
The new age of the phage	23
Epigenetics and chemical exposures	23
Sulfate: a neglected (but potentially highly relevant) anion	23
Evo-devo perspectives on cancer	22
Crossroads between copper ions and amyloid formation in Parkinson’s disease	22
WNT signaling and cancer stemness	22
Shaping Hox gene activity to generate morphological diversity across vertebrate phylogeny	21
When, where, and why specialised metabolites are produced: inferring function from expression control	21
How phosphorylation impacts intrinsically disordered proteins and their function	21
Insights into the regulation of malate dehydrogenase: inhibitors, activators, and allosteric modulation by small molecules	21
Malate dehydrogenase (MDH) in cancer: a promiscuous enzyme, a redox regulator, and a metabolic co-conspirator	21
Mitochondrial Ca2+ handling as a cell signaling hub: lessons from astrocyte function	21
Immunologically relevant effects of radiation therapy on the tumor microenvironment	20
Immunotherapy for hypertensive end-organ damage: a new therapeutic strategy	20
The COP9 signalosome variants CSNCSN7A and CSNCSN7B form complexes with specific CRLs which are targets of autophagy	19
The interplay between lytic polysaccharide monooxygenases and glycoside hydrolases	19
Quantification of persulfidation on specific proteins: are we nearly there yet?	19
The role of the Mediator complex in fungal pathogenesis and response to antifungal agents	18
Evolution and functional diversification of yeast sugar transporters	18
Molecular divergence with major morphological consequences: development and evolution of organ size and shape	18
Molecular plant immunity against biotrophic, hemibiotrophic, and necrotrophic fungi	18
Using epigenetic clocks in environmental epigenetics: recommendations for estimating biological aging in perinatal and pediatric samples	18
Emerging strategies in lymph node-targeted nano-delivery systems for tumor immunotherapy	18
Ubiquitin signatures on aggregating proteins in neurodegeneration	18
Direct recognition of pathogen effectors by plant NLR immune receptors and downstream signalling	17
Indirect recognition of pathogen effectors by NLRs	17
Specificity and diversity of Klebsiella pneumoniae phage-encoded capsule depolymerases	17
DNA double strand break repair: a model of specificity and complexity in SUMO signalling	17
Chemical approaches to the sulfation of small molecules: current progress and future directions	17

A proteostasis network safeguards the chloroplast proteome	17
Cytosolic sulfotransferases in endocrine disruption	16
Gliotoxin and related metabolites as zinc chelators: implications and exploitation to overcome antimicrobial resistance	16
Gut bacterial alginate degrading enzymes	16
Mass spectrometry of intact membrane proteins: shifting towards a more native-like context	16
Astrocytes in the pathophysiology of neuroinfection	16
Cross-talk between energy and redox metabolism in astrocyte-neuron functional cooperation	16
Seeing the complete picture: proteins in top-down mass spectrometry	16
Mechanisms of resistance to tyrosine kinase inhibitors in liver cancer stem cells and potential therapeutic approaches	15
Kinetic modelling of glycolytic oscillations	15
Phage-specific antibodies: are they a hurdle for the success of phage therapy?	14
Unconventional R proteins in the botanical tribe Triticeae	14
Understanding SUMO-mediated adaptive responses in plants to improve crop productivity	14
Effect of multimodularity and spatial organization of glycoside hydrolases on catalysis	14
The many faces of p97/Cdc48 in mitochondrial homeostasis	14
Activation and turnover of the plant immune signaling kinase BIK1: a fine balance	14
Targeting protein kinases in cancer stem cells	14
Small-molecule degron mimetics for targeted protein degradation	14
Developments in rapid hydrogen–deuterium exchange methods	14
Diverse mycotoxin threats to safe food and feed cereals	14
What’s new in protein kinase/phosphatase signalling in the control of plant immunity?	14
NUAK: never underestimate a kinase	14
Role of p62 nuclear condensates in regulating ubiquitin-mediated proteasomal degradation	14
Is the TCA cycle malate dehydrogenase-citrate synthase metabolon an illusion?	14
AMPK and O-GlcNAcylation: interplay in cardiac pathologies and heart failure	13
Transposon mutagenesis in bacterial natural product discovery	13
Physiology of malate dehydrogenase and how dysregulation leads to disease	13
Ubiquitin ligases at the nexus of plant responses to biotic and abiotic stresses	13
Surface-sampling mass spectrometry to study proteins and protein complexes	13
Oxysterol sulfates in fluids, cells and tissues: how much do we know about their clinical significance, biological relevance and biophysical implications?	13
Saccharomyces cerevisiae as a tool for deciphering Hsp90 molecular chaperone function	13
The chameleonic behavior of p53 in health and disease: the transition from a client to an aberrant condensate scaffold in cancer	13
Computational methods for processing and interpreting mass spectrometry-based metabolomics	12
Unravelling 3D growth in the moss Physcomitrium patens	12
Modelling the evolution of novelty: a review	12
Hijacking the Ubl code: bacterial manipulation of ubiquitin-like proteins	12
Different states and the associated fates of biomolecular condensates	12
Structure and function of microbial α-l-fucosidases: a mini review	12
The Ubiquitin Script: writing protein fates in chains	12
Lytic polysaccharide monooxygenases: enzymes for controlled and site-specific Fenton-like chemistry	12
Sulfation pathways in times of change	11
Beyond degradation tags: How FAT10 and ubiquitin shape substrate energy landscapes	11
Volatile uptake, transport, perception, and signaling shape a plant’s nose	11
A comparative guide to expression systems for phage lysin production	11
Translational research priorities for bacteriophage therapeutics	11
Astrocytes as metabolic suppliers to support neuronal activity and brain functions	11
Functional benefit of structural disorder for the replication of measles, Nipah and Hendra viruses	11
Immune-regulating extracellular vesicles: a new frontier in autoimmune disease therapy	11
Mucin utilization by gut microbiota: recent advances on characterization of key enzymes	11
Evolution of SLiM-mediated hijack functions in intrinsically disordered viral proteins	10
Mannuronate C-5 epimerases and their use in alginate modification	10
Does AMPK bind glycogen in skeletal muscle or is the relationship correlative?	10
Dysbiosis and the gut–brain axis impairment in the pathophysiology of Alzheimer’s disease and related dementias: is ‘pathobiome’ an etiological element?	10
Ubiquitination of the ubiquitin-binding machinery: how early ESCRT components are controlled	10
Cross-linking mass spectrometry for mapping protein complex topologies in situ	10
Epigenetic impact of endocrine-disrupting chemicals on atherosclerosis	9
Interplay between phytohormone signalling pathways in plant defence – other than salicylic acid and jasmonic acid	9
New molecules in plant defence against pathogens	9
Mechanisms of bioleaching: iron and sulfur oxidation by acidophilic microorganisms	9
HECT ubiquitin ligases as accessory proteins of the plant proteasome	9
Astrocyte adaptation in Alzheimer’s disease: a focus on astrocytic P2X7R	9
Catalytic mechanism and kinetics of malate dehydrogenase	9
Bacterial tryptophan metabolites in cancer and atherosclerosis: insights for a role in immune checkpoint inhibition	9
Non-covalent SUMO interactions with (de)conjugation enzymes	9