OOIR: Observatory of International Research

Papers

(The median citation count of Essays in Biochemistry is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
CRISPR screening in cancer stem cells	183
How viral proteins bind short linear motifs and intrinsically disordered domains	149
CaMKK2: bridging the gap between Ca2+ signaling and energy-sensing	147
Phase separation of the microtubule-associated protein tau	104
Butyrate-producing colonic clostridia: picky glycan utilization specialists	78
Inter-species horizontal transfer of biosynthetic gene clusters: an evolutionary driver for chemical diversity in bacterial communities	70
Salicylic acid and jasmonic acid crosstalk in plant immunity	68
Apoplastic and vascular defences	65
Heterologous expression of NRPS and PKS pathways in Escherichia coli : from bottlenecks to biosynthetic platforms	65
Can changes in 3D genome architecture create new regulatory landscapes that contribute to phenotypic evolution?	62
DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling	61
Versatile roles of inositol hexakisphosphate in the ubiquitin-proteasome system	60
The dual role of the ubiquitin–proteasome system in photomorphogenesis	56
The role of methionine synthases in fungal metabolism and virulence	54
Astrocytes in memory formation and maintenance	53
Malate dehydrogenase: a story of diverse evolutionary radiation	52
Expanding perspectives on specialized metabolism in Streptomyces bacteria	50
A special issue of Essays in Biochemistry on evolutionary developmental biology	50
O-Mucin-degrading carbohydrate-active enzymes and their possible implication in inflammatory bowel diseases	49
Branched-chain amino acid biosynthesis in fungi	48
Mass spectrometric insights into protein aggregation	48
Colony politics to chemical warfare: phenotypic plasticity in Streptomyces	47
The cGAS-STING pathway in cancer immunity: dual roles, therapeutic strategies, and clinical challenges	46
Shapeshifting proteins: the role of structural disorder and conformational plasticity in physiology and disease	45
Harnessing extremophilic carboxylesterases for applications in polyester depolymerisation and plastic waste recycling	42

Functional amyloid in a lipid-like environment: a merry dance of many steps	41
Modulating immune cells within pancreatic ductal adenocarcinoma via nanomedicine	40
Hemicellulolytic enzymes in lignocellulose processing	39
Systemic acquired resistance-associated transport and metabolic regulation of salicylic acid and glycerol-3-phosphate	38
Prostate cancer as a dedifferentiated organ: androgen receptor, cancer stem cells, and cancer stemness	38
Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling	36
Imaging of biofilms using cryo-scanning electron microscopy	35
Nitrification in acidic and alkaline environments	35
Lipids and the cancer stemness regulatory system in acute myeloid leukemia	32
Phase separation and other forms of α-Synuclein self-assemblies	32
Mesolens imaging in microbiology	29
Insight into the structure and molecular mode of action of plant paired NLR immune receptors	29
The molecular basis of cereal grain proteostasis	29
The road less travelled? Exploring the nuanced evolutionary consequences of duplicated genes	29
Regulation of R-loops by nucleic acid and protein modifications	29
Long non-coding RNA and ribosomal protein genes in a yeast ageing model: an investigation for undergraduate research-based learning	28
Developing physical seed priming as a practical tool for stress-resilient crop production	27
Plant proteostasis: a proven and promising target for crop improvement	27
NEDD8, stress granules, and amyotrophic lateral sclerosis: unveiling the therapeutic potential of the NEDP1 protease	26
Astrocyte heterogeneity and interactions with local neural circuits	26
Oxidative stress – Alzheimer’s disease – DNA methylation: the role of arsenic	25
Epigenetics and chemical exposures	23
UFM1 at the endoplasmic reticulum: linking ER stress, ribosome quality control, and ER-phagy	23
Acetylation, ADP-ribosylation and methylation of malate dehydrogenase	23
Astroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?	23
Reactive oxygen species and oxidative signalling in plants	23
Harnessing neutrophil plasticity for HCC immunotherapy	23
Evolution of resistance (R) gene specificity	23
Crossroads between copper ions and amyloid formation in Parkinson’s disease	22
The new age of the phage	22
How phosphorylation impacts intrinsically disordered proteins and their function	21
Sulfate: a neglected (but potentially highly relevant) anion	21
Evo-devo perspectives on cancer	21
When, where, and why specialised metabolites are produced: inferring function from expression control	20
Malate dehydrogenase (MDH) in cancer: a promiscuous enzyme, a redox regulator, and a metabolic co-conspirator	20
Insights into the regulation of malate dehydrogenase: inhibitors, activators, and allosteric modulation by small molecules	20
Mitochondrial Ca2+ handling as a cell signaling hub: lessons from astrocyte function	20
WNT signaling and cancer stemness	20
Using epigenetic clocks in environmental epigenetics: recommendations for estimating biological aging in perinatal and pediatric samples	19
Shaping Hox gene activity to generate morphological diversity across vertebrate phylogeny	19
Immunotherapy for hypertensive end-organ damage: a new therapeutic strategy	19
Quantification of persulfidation on specific proteins: are we nearly there yet?	19
Immunologically relevant effects of radiation therapy on the tumor microenvironment	18
A guide to Direct Pathway Cloning (DiPaC) for natural product discovery	18
The interplay between lytic polysaccharide monooxygenases and glycoside hydrolases	18
Emerging strategies in lymph node-targeted nano-delivery systems for tumor immunotherapy	18
Molecular divergence with major morphological consequences: development and evolution of organ size and shape	18
The role of the Mediator complex in fungal pathogenesis and response to antifungal agents	18
The COP9 signalosome variants CSNCSN7A and CSNCSN7B form complexes with specific CRLs which are targets of autophagy	18
Ubiquitin signatures on aggregating proteins in neurodegeneration	17

Direct recognition of pathogen effectors by plant NLR immune receptors and downstream signalling	17
Specificity and diversity of Klebsiella pneumoniae phage-encoded capsule depolymerases	17
Chemical approaches to the sulfation of small molecules: current progress and future directions	17
Bacterial weaponry and the ecological factors of competitive success	17
Evolution and functional diversification of yeast sugar transporters	17
Molecular plant immunity against biotrophic, hemibiotrophic, and necrotrophic fungi	17
Gliotoxin and related metabolites as zinc chelators: implications and exploitation to overcome antimicrobial resistance	17
Indirect recognition of pathogen effectors by NLRs	16
Cytosolic sulfotransferases in endocrine disruption	16
Seeing the complete picture: proteins in top-down mass spectrometry	16
Astrocytes in the pathophysiology of neuroinfection	15
A proteostasis network safeguards the chloroplast proteome	15
DNA double strand break repair: a model of specificity and complexity in SUMO signalling	15
Cross-talk between energy and redox metabolism in astrocyte-neuron functional cooperation	15
Mass spectrometry of intact membrane proteins: shifting towards a more native-like context	15
Gut bacterial alginate degrading enzymes	14
Unconventional R proteins in the botanical tribe Triticeae	14
Gut microbiota and disease	14
Is the TCA cycle malate dehydrogenase-citrate synthase metabolon an illusion?	14
Mechanisms of resistance to tyrosine kinase inhibitors in liver cancer stem cells and potential therapeutic approaches	14
What’s new in protein kinase/phosphatase signalling in the control of plant immunity?	14
Effect of multimodularity and spatial organization of glycoside hydrolases on catalysis	14
Understanding SUMO-mediated adaptive responses in plants to improve crop productivity	14
Kinetic modelling of glycolytic oscillations	14
Small-molecule degron mimetics for targeted protein degradation	14
Diverse mycotoxin threats to safe food and feed cereals	13
Developments in rapid hydrogen–deuterium exchange methods	13
Activation and turnover of the plant immune signaling kinase BIK1: a fine balance	13
The many faces of p97/Cdc48 in mitochondrial homeostasis	13
Targeting protein kinases in cancer stem cells	13
NUAK: never underestimate a kinase	13
Role of p62 nuclear condensates in regulating ubiquitin-mediated proteasomal degradation	13
A special issue of Essays in Biochemistry on proteasome and protein degradation	12
AMPK and O-GlcNAcylation: interplay in cardiac pathologies and heart failure	12
Surface-sampling mass spectrometry to study proteins and protein complexes	12
Oxysterol sulfates in fluids, cells and tissues: how much do we know about their clinical significance, biological relevance and biophysical implications?	12
Transposon mutagenesis in bacterial natural product discovery	12
The chameleonic behavior of p53 in health and disease: the transition from a client to an aberrant condensate scaffold in cancer	12
Phage-specific antibodies: are they a hurdle for the success of phage therapy?	12
Bacterial biosynthetic superclusters: emerging drivers of synergistic natural products against antimicrobial resistance	12
Physiology of malate dehydrogenase and how dysregulation leads to disease	12
Synthetic microbial communities for studying the fate and ecological role of specialized metabolites	12
Plant metabolic adaptation to nitrogen scarcity: the role of biological nitrification inhibitors	12
Ubiquitin ligases at the nexus of plant responses to biotic and abiotic stresses	12
The Ubiquitin Script: writing protein fates in chains	11
Functional benefit of structural disorder for the replication of measles, Nipah and Hendra viruses	11
Saccharomyces cerevisiae as a tool for deciphering Hsp90 molecular chaperone function	11
Hijacking the Ubl code: bacterial manipulation of ubiquitin-like proteins	11
Different states and the associated fates of biomolecular condensates	11
Lytic polysaccharide monooxygenases: enzymes for controlled and site-specific Fenton-like chemistry	11
Structure and function of microbial α-l-fucosidases: a mini review	11
Modelling the evolution of novelty: a review	11
Sulfation pathways in times of change	10
Translational research priorities for bacteriophage therapeutics	10
Unravelling 3D growth in the moss Physcomitrium patens	10
How social is social resistance?	10
A comparative guide to expression systems for phage lysin production	10
Computational methods for processing and interpreting mass spectrometry-based metabolomics	10
Volatile uptake, transport, perception, and signaling shape a plant’s nose	10
Immune-regulating extracellular vesicles: a new frontier in autoimmune disease therapy	9
Beyond degradation tags: How FAT10 and ubiquitin shape substrate energy landscapes	9
Astrocytes as metabolic suppliers to support neuronal activity and brain functions	9
Epigenetic impact of endocrine-disrupting chemicals on atherosclerosis	9
Mucin utilization by gut microbiota: recent advances on characterization of key enzymes	9
Catalytic mechanism and kinetics of malate dehydrogenase	8
Astrocyte adaptation in Alzheimer’s disease: a focus on astrocytic P2X7R	8
Evolution of SLiM-mediated hijack functions in intrinsically disordered viral proteins	8
Cross-linking mass spectrometry for mapping protein complex topologies in situ	8
Mannuronate C-5 epimerases and their use in alginate modification	8
Bacterial tryptophan metabolites in cancer and atherosclerosis: insights for a role in immune checkpoint inhibition	8
New molecules in plant defence against pathogens	8
Ubiquitination of the ubiquitin-binding machinery: how early ESCRT components are controlled	8
Non-covalent SUMO interactions with (de)conjugation enzymes	8
Dysbiosis and the gut–brain axis impairment in the pathophysiology of Alzheimer’s disease and related dementias: is ‘pathobiome’ an etiological element?	8
Does AMPK bind glycogen in skeletal muscle or is the relationship correlative?	8
Mechanisms of bioleaching: iron and sulfur oxidation by acidophilic microorganisms	8
The role of phages in plant-associated microbial communities	8