Essays in Biochemistry

Article	Citations
CRISPR screening in cancer stem cells	200
How viral proteins bind short linear motifs and intrinsically disordered domains	162
Phase separation of the microtubule-associated protein tau	159
Heterologous expression of NRPS and PKS pathways in Escherichia coli : from bottlenecks to biosynthetic platforms	115
Inter-species horizontal transfer of biosynthetic gene clusters: an evolutionary driver for chemical diversity in bacterial communities	85
CaMKK2: bridging the gap between Ca2+ signaling and energy-sensing	85
Salicylic acid and jasmonic acid crosstalk in plant immunity	83
Butyrate-producing colonic clostridia: picky glycan utilization specialists	73
The role of methionine synthases in fungal metabolism and virulence	71
The dual role of the ubiquitin–proteasome system in photomorphogenesis	69
Astrocytes in memory formation and maintenance	68
Expanding perspectives on specialized metabolism in Streptomyces bacteria	63
Bacterial–fungal interactions: connections and consequences	58
Apoplastic and vascular defences	58
Can changes in 3D genome architecture create new regulatory landscapes that contribute to phenotypic evolution?	55
Versatile roles of inositol hexakisphosphate in the ubiquitin-proteasome system	54
Malate dehydrogenase: a story of diverse evolutionary radiation	52
DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling	52
O-Mucin-degrading carbohydrate-active enzymes and their possible implication in inflammatory bowel diseases	51
Mass spectrometric insights into protein aggregation	51
A special issue of Essays in Biochemistry on evolutionary developmental biology	51
Translating biosynthetic gene cluster architecture into biosensor design for microbial natural product discovery	51
The cGAS-STING pathway in cancer immunity: dual roles, therapeutic strategies, and clinical challenges	51
Colony politics to chemical warfare: phenotypic plasticity in Streptomyces	47
Intra- and inter-biosynthetic gene cluster allelic variation as drivers of chemical diversification in Streptomyces	46

Shapeshifting proteins: the role of structural disorder and conformational plasticity in physiology and disease	44
Functional amyloid in a lipid-like environment: a merry dance of many steps	44
Branched-chain amino acid biosynthesis in fungi	44
Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling	43
Harnessing extremophilic carboxylesterases for applications in polyester depolymerisation and plastic waste recycling	40
Hemicellulolytic enzymes in lignocellulose processing	40
Modulating immune cells within pancreatic ductal adenocarcinoma via nanomedicine	39
Nitrification in acidic and alkaline environments	36
Prostate cancer as a dedifferentiated organ: androgen receptor, cancer stem cells, and cancer stemness	35
Imaging of biofilms using cryo-scanning electron microscopy	34
Mesolens imaging in microbiology	31
Systemic acquired resistance-associated transport and metabolic regulation of salicylic acid and glycerol-3-phosphate	31
The molecular basis of cereal grain proteostasis	31
Lipids and the cancer stemness regulatory system in acute myeloid leukemia	30
Regulation of R-loops by nucleic acid and protein modifications	30
Phase separation and other forms of α-Synuclein self-assemblies	30
Insight into the structure and molecular mode of action of plant paired NLR immune receptors	29
The road less travelled? Exploring the nuanced evolutionary consequences of duplicated genes	29
The enabling power of chemical probes: examples from the nuclear hormone receptor field	29
Long non-coding RNA and ribosomal protein genes in a yeast ageing model: an investigation for undergraduate research-based learning	28
Plant proteostasis: a proven and promising target for crop improvement	27
NEDD8, stress granules, and amyotrophic lateral sclerosis: unveiling the therapeutic potential of the NEDP1 protease	27
Astroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?	26
Developing physical seed priming as a practical tool for stress-resilient crop production	26
Evolution of resistance (R) gene specificity	25
Oxidative stress – Alzheimer’s disease – DNA methylation: the role of arsenic	25
Astrocyte heterogeneity and interactions with local neural circuits	24
Crossroads between copper ions and amyloid formation in Parkinson’s disease	24
Harnessing neutrophil plasticity for HCC immunotherapy	24
The new age of the phage	24
UFM1 at the endoplasmic reticulum: linking ER stress, ribosome quality control, and ER-phagy	24
Acetylation, ADP-ribosylation and methylation of malate dehydrogenase	22
Reactive oxygen species and oxidative signalling in plants	22
Sulfate: a neglected (but potentially highly relevant) anion	22
Epigenetics and chemical exposures	22
Evo-devo perspectives on cancer	22
When, where, and why specialised metabolites are produced: inferring function from expression control	21
Insights into the regulation of malate dehydrogenase: inhibitors, activators, and allosteric modulation by small molecules	21
Malate dehydrogenase (MDH) in cancer: a promiscuous enzyme, a redox regulator, and a metabolic co-conspirator	21
Mitochondrial Ca2+ handling as a cell signaling hub: lessons from astrocyte function	21
WNT signaling and cancer stemness	21
The COP9 signalosome variants CSNCSN7A and CSNCSN7B form complexes with specific CRLs which are targets of autophagy	20
Shaping Hox gene activity to generate morphological diversity across vertebrate phylogeny	20
A guide to Direct Pathway Cloning (DiPaC) for natural product discovery	20
How phosphorylation impacts intrinsically disordered proteins and their function	20
Immunotherapy for hypertensive end-organ damage: a new therapeutic strategy	20
Quantification of persulfidation on specific proteins: are we nearly there yet?	20
Molecular divergence with major morphological consequences: development and evolution of organ size and shape	19
Direct recognition of pathogen effectors by plant NLR immune receptors and downstream signalling	19
Using epigenetic clocks in environmental epigenetics: recommendations for estimating biological aging in perinatal and pediatric samples	19

The role of the Mediator complex in fungal pathogenesis and response to antifungal agents	19
It takes a village: how plant-associated bacterial communities socialise to shape plant growth and health	19
Immunologically relevant effects of radiation therapy on the tumor microenvironment	19
The interplay between lytic polysaccharide monooxygenases and glycoside hydrolases	19
Emerging strategies in lymph node-targeted nano-delivery systems for tumor immunotherapy	18
Molecular plant immunity against biotrophic, hemibiotrophic, and necrotrophic fungi	18
Forest tree–pathogen interactions under climate change	17
Chemical approaches to the sulfation of small molecules: current progress and future directions	17
Specificity and diversity of Klebsiella pneumoniae phage-encoded capsule depolymerases	17
Distribution of lactone-signaling system for expression of secondary metabolite biosynthetic gene clusters in Streptomyces species	17
Ubiquitin signatures on aggregating proteins in neurodegeneration	17
Bacterial weaponry and the ecological factors of competitive success	17
Evolution and functional diversification of yeast sugar transporters	17
Gliotoxin and related metabolites as zinc chelators: implications and exploitation to overcome antimicrobial resistance	16
Astrocytes in the pathophysiology of neuroinfection	16
A proteostasis network safeguards the chloroplast proteome	16
DNA double strand break repair: a model of specificity and complexity in SUMO signalling	16
Mass spectrometry of intact membrane proteins: shifting towards a more native-like context	16
Indirect recognition of pathogen effectors by NLRs	16
Cytosolic sulfotransferases in endocrine disruption	15
Kinetic modelling of glycolytic oscillations	15
Cross-talk between energy and redox metabolism in astrocyte-neuron functional cooperation	15
Gut microbiota and disease	15
Seeing the complete picture: proteins in top-down mass spectrometry	15
Gut bacterial alginate degrading enzymes	14
Diverse mycotoxin threats to safe food and feed cereals	14
Mechanisms of resistance to tyrosine kinase inhibitors in liver cancer stem cells and potential therapeutic approaches	14
Unconventional R proteins in the botanical tribe Triticeae	14
Understanding SUMO-mediated adaptive responses in plants to improve crop productivity	14
NUAK: never underestimate a kinase	14
What’s new in protein kinase/phosphatase signalling in the control of plant immunity?	14
Is the TCA cycle malate dehydrogenase-citrate synthase metabolon an illusion?	14
Role of p62 nuclear condensates in regulating ubiquitin-mediated proteasomal degradation	14
Developments in rapid hydrogen–deuterium exchange methods	13
Plant defence priming and memory mechanisms under climate change	13
Small-molecule degron mimetics for targeted protein degradation	13
Activation and turnover of the plant immune signaling kinase BIK1: a fine balance	13
Effect of multimodularity and spatial organization of glycoside hydrolases on catalysis	13
The plant holobiont: integrating molecular priming and ecological legacies for climate-adaptive immunity	13
Bacterial biosynthetic superclusters: emerging drivers of synergistic natural products against antimicrobial resistance	13
The many faces of p97/Cdc48 in mitochondrial homeostasis	13
Phage-specific antibodies: are they a hurdle for the success of phage therapy?	13
Targeting protein kinases in cancer stem cells	13
Synthetic microbial communities for studying the fate and ecological role of specialized metabolites	12
Oxysterol sulfates in fluids, cells and tissues: how much do we know about their clinical significance, biological relevance and biophysical implications?	12
Physiology of malate dehydrogenase and how dysregulation leads to disease	12
The chameleonic behavior of p53 in health and disease: the transition from a client to an aberrant condensate scaffold in cancer	12
Ubiquitin ligases at the nexus of plant responses to biotic and abiotic stresses	12
A special issue of Essays in Biochemistry on proteasome and protein degradation	12
Surface-sampling mass spectrometry to study proteins and protein complexes	12
Transposon mutagenesis in bacterial natural product discovery	12
Different states and the associated fates of biomolecular condensates	11
Saccharomyces cerevisiae as a tool for deciphering Hsp90 molecular chaperone function	11
Plant metabolic adaptation to nitrogen scarcity: the role of biological nitrification inhibitors	11
Modelling the evolution of novelty: a review	11
AMPK and O-GlcNAcylation: interplay in cardiac pathologies and heart failure	11
Invasive plasmids as ecosystem engineers—from mechanism to application	10
The Ubiquitin Script: writing protein fates in chains	10
Computational methods for processing and interpreting mass spectrometry-based metabolomics	10
Considering internal conflict in the face of natural product biosynthesis and biosynthetic gene cluster evolution	10
Lytic polysaccharide monooxygenases: enzymes for controlled and site-specific Fenton-like chemistry	10
How social is social resistance?	10
Unravelling 3D growth in the moss Physcomitrium patens	10
Hijacking the Ubl code: bacterial manipulation of ubiquitin-like proteins	10
Functional benefit of structural disorder for the replication of measles, Nipah and Hendra viruses	10
Structure and function of microbial α-l-fucosidases: a mini review	10
Sulfation pathways in times of change	9
A comparative guide to expression systems for phage lysin production	9
Beyond degradation tags: How FAT10 and ubiquitin shape substrate energy landscapes	9
Mucin utilization by gut microbiota: recent advances on characterization of key enzymes	9
Astrocytes as metabolic suppliers to support neuronal activity and brain functions	9
Immune-regulating extracellular vesicles: a new frontier in autoimmune disease therapy	9
Volatile uptake, transport, perception, and signaling shape a plant’s nose	8
Non-covalent SUMO interactions with (de)conjugation enzymes	8
Bacterial tryptophan metabolites in cancer and atherosclerosis: insights for a role in immune checkpoint inhibition	8
Mechanisms of bioleaching: iron and sulfur oxidation by acidophilic microorganisms	8
New molecules in plant defence against pathogens	8
Evolution of SLiM-mediated hijack functions in intrinsically disordered viral proteins	8
Astrocyte adaptation in Alzheimer’s disease: a focus on astrocytic P2X7R	8
Mannuronate C-5 epimerases and their use in alginate modification	8

Catalytic mechanism and kinetics of malate dehydrogenase	8
Translational research priorities for bacteriophage therapeutics	8
Cross-linking mass spectrometry for mapping protein complex topologies in situ	8
The role of phages in plant-associated microbial communities	8
Epigenetic impact of endocrine-disrupting chemicals on atherosclerosis	8