OOIR: Observatory of International Research

Papers

(The TQCC of Annual Review of Biochemistry is 38. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-12-01 to 2024-12-01.)

Article	Citations
The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators	228
Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis	151
The Initiation of Eukaryotic DNA Replication	136
Repair of DNA Double-Strand Breaks by the Nonhomologous End Joining Pathway	107
Synonymous but Not Silent: The Codon Usage Code for Gene Expression and Protein Folding	102
Understanding the Function of Mammalian Sirtuins and Protein Lysine Acylation	90
Mechanisms of Vertebrate DNA Interstrand Cross-Link Repair	89
The Form and Function of PIEZO2	78
A Natural Product Chemist's Guide to Unlocking Silent Biosynthetic Gene Clusters	75
Chaperoning SNARE Folding and Assembly	74
Mechanisms for Regulating and Organizing Receptor Signaling by Endocytosis	72
Better, Faster, Cheaper: Recent Advances in Cryo–Electron Microscopy	71
Mitochondrial DNA Release in Innate Immune Signaling	66
The Proteins of mRNA Modification: Writers, Readers, and Erasers	62
MAPK-Activated Protein Kinases: Servant or Partner?	61
mRNA Regulation by RNA Modifications	61
Biochemistry, Cell Biology, and Pathophysiology of the Innate Immune cGAS–cGAMP–STING Pathway	60
Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory	59
Repair of DNA Breaks by Break-Induced Replication	58
Tunnels for Protein Export from the Endoplasmic Reticulum	53
Role of the TOM Complex in Protein Import into Mitochondria: Structural Views	51
Posttranslational Regulation of HMG CoA Reductase, the Rate-Limiting Enzyme in Synthesis of Cholesterol	49
DNA–Protein Crosslinks and Their Resolution	48
Structural Mechanism of Transport of Mitochondrial Carriers	44
Molecules from the Microbiome	44

Structural Insights Accelerate the Discovery of Opioid Alternatives	38
Preparing Better Samples for Cryo–Electron Microscopy: Biochemical Challenges Do Not End with Isolation and Purification	38