OOIR: Observatory of International Research

Papers

(The TQCC of Xenobiotica is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
A cysteine trapping assay for risk assessment of reactive acyl CoA metabolites	22
Formulation of apigenin-loaded solid lipid nanoparticles: characterisation, molecular docking, and anticancer assay	18
One small step in time, one giant leap for DMPK kind – a CRO perspective of the evolving core discipline of drug development	16
Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver	13
Academic foreign compound metabolism – ‘ quo vadis ’?	12
Developmental stage and infection status may affect drug distribution in the prostate of rats	11
Population pharmacokinetics of sirolimus in Chinese adult liver transplant recipients: a retrospective study	10
Apigenin Derivatives as Promising Norovirus RdRp Inhibitors: Insights from In Silico Docking and Molecular Dynamics Studies	9
In vitro hepatic metabolism of the natural product quebecol	9
Diisononyl phthalate down-regulates the expression of antioxidant genes NFE2L2 , TXN , and TXNRD2 , while d	8
Utility of preclinical species for uncertainty assessment and correction of prediction of human volume of distribution using the Rodgers-Lukacova model	8
Meeting report: oligonucleotide ADME workshop	8
Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2	8
Nrf2 signaling pathway studies in Drosophila melanogaster : parallel roles in human health and insect environmental responses	8
In silico models to predict tubular secretion or reabsorption clearance pathway using physicochemical properties and structural characteristics	8
Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver	7
Population pharmacokinetics and dosage optimisation of tacrolimus coadministration with Wuzhi capsule in adult liver transplant patients	7
Effects of the total flavonoid extracts and the monomers of Daphne genkwa on CYP2C8 activity	7
Three methods to optimise polymyxin B dosing using estimated AUC after first dose: validation with the data generated by Monte Carlo simulation	7
Comparisons between human and rodent hepatic glutathione S-Transferase activities reveal sex and species differences	7
Metabolic activation of zolmitriptan mediated by CYP2D6	7
Effect of genetic polymorphisms on the pharmacokinetics of gefitinib in healthy Chinese volunteers	7
Adenine-related compounds modulate UDP-glucuronosyltransferase (UGT) activity in mouse liver microsomes	7
In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor	7
Notable drug-drug interaction between omeprazole and voriconazole in CYP2C19 1 and 2 (rs4244285, 681G>A) alleles in vitro	7

Power of integrating PBPK with PBBM (PBPK-BM): a single model predicting food effect, gender impact, drug-drug interactions and bioequivalence in fasting & fed conditions	7
In vivo evaluation of pharmacokinetic drug–drug interactions between fluorinated pyrimidine anticancer drugs, 5-fluorouracil and capecitabin, and an anticoagulant, warfarin	7
Arctigenin-induced erythrocyte membrane remodelling is mediated through calcium influx, metabolic collapse, and casein kinase 1α	7
Preparation, characterisation, pharmacokinetics and distribution of esculin microspheres administered via intravitreal injection into rabbit brain	7
Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P ₁ modulator ponesimod	6
Absorption, distribution, metabolism, and excretion of [¹⁴C]TPN729 after oral administration to rats	6
Safflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics	6
2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A2	6
Defining the enzymes of xenobiotic metabolism – a forlorn hope?	6
Beyond cytotoxic potency: disposition features required to design ADC payload	6
An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds	6
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle	6
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-M	6
Bioavailability, safety and tolerability of intravenous brivaracetam in healthy Japanese participants	6
Renal tubular transporter-mediated interactions between mirogabalin and cimetidine in rats	6
Prediction of the neurotoxic mechanisms of the pesticide phorate using network toxicology, molecular docking, and molecular dynamics simulation	6
New era in bioequivalence global harmonization through ICH M13 initiative: critical review on new concepts, alternative approaches for high-risk products	6
Machine learning-driven bioavailability prediction in early-stage drug development: a KNIME-based computational workflow for digital health applications	6
The effect of ARVs on the MEKKK1 gene promoter, inflammatory cytokine expression and signalling in acute treated Jurkat T cells	6
Experimental and computational models to investigate intestinal drug permeability and metabolism	6
Development of eugenol-fortified fisetin-loaded nano-invasomes gel	6
N-Acetyltransferase 2, glutathione S-transferase gene polymorphisms and susceptibility to hepatocellular carcinoma in an Algerian population	6
Pharmacokinetics and multi-peak phenomenon analysis of novel anti-Parkinson’s drug FLZ after multi-dose in cynomolgus monkeys	5
Monomethyl auristatin E (MMAE), a payload for multiple antibody drug conjugates (ADCs), demonstrates differential red blood cell partitioning across human and animal species	5
Meeting report of the 3rd European Biotransformation Workshop	5
Sanguinarine-induced proteomic changes in methicillin-resistant Staphylococcus aureus	5
Interactions of organophosphorus pesticides with ATP-binding cassette (ABC) drug transporters	5
Metabolism of gartanin in liver microsomes and its modulating effects on cytochrome P450s	5
Mechanism of Black American Ginseng saponins in ameliorating memory dysfunction in aging mice by activating the BDNF/PI3K/AKT/CREB pathway	5
Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation	5
Preface for special issue: “Emerging strategies, technologies, and approaches for the next generation ADCs”	5
Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir	5
Effects of tyrosine kinase inhibitors used for the treatment of non-small cell lung carcinoma on cytochrome P450 2J2 activities	5
Evobrutinib pathway to its major metabolite M463-2 and insights from a biotransformation and DDI perspective	5
DEC1 negatively regulates CYP2B6 expression by binding to the CYP2B6 promoter region ascribed to IL-6-induced downregulation of CYP2B6 expression in HeLa cells	5
Nano-pharmacokinetics and pharmacodynamics of green-synthesized ZnO nanoparticles: a pathway to safer therapeutic applications	5
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study	5
2-Naphthalenemethanol participates in metabolic activation of 2-methylnaphthalene	5
Application of physiologically based pharmacokinetic models for therapeutic proteins and other novel modalities	5
Effectiveness of pain care intervention combined with traditional Chinese medicine care in the perioperative care of patients with urinary stones	5
Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats	5
Impact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats	5
Elucidation of clearance mechanism of TP0463518, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor: does a species difference in excretion routes exist between humans and animals?	5
The effects of genetic polymorphism on toxicity and pharmacokinetics of methotrexate in Egyptian adult patients with leukaemia or lymphoma	5
Preclinical assessment of the PI3Kα selective inhibitor inavolisib and prediction of its pharmacokinetics and efficacious dose in human	5
Bioavailability and dose proportionality of a highly lipophilic phenolic antioxidant	5
A population pharmacokinetic-pharmacodynamic model of navtemadlin, its glucuronide metabolite (M1) and serum macrophage inhibitory cykokine-1 (MIC-1)	4
Species differences in oxidative metabolism of regorafenib	4
Potential influence of interleukin-6 -174G/C gene polymorphism on kidney graft function and tacrolimus dose requirements: five-year follow-up	4
Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury	4

Drug-drug interaction between danshensu and irbesartan and its potential mechanism	4
A physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model for the insecticide dimethoate	4
Inorganic mercury pharmacokinetics in man: a hybrid model	4
Characterisation of seven medications approved for attention-deficit/hyperactivity disorder usingin vitromodels of hepatic metabolism	4
Sodium dodecylbenzene sulphonate (SDBS) present in detergents: action on the gills, skin, and blood of D. rerio fish	4
Metabolic profiling in liver microsomes and mice of E28, a potent FLT3 inhibitor	4
Mirogabalin, a novel α₂δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K	4
The impact of CYP3A5 , NR1I2 , and POR polymorphisms on tacrolimus dose-adjusted concentration and clinical	4
Pharmacokinetics, metabolism and excretion of radiolabeled fostemsavir administered with or without ritonavir in healthy male subjects	4
Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration	4
Predictive marker for exposure-driven haematological toxicity of tegafur-uracil and proposed modified-dosage regimen by pharmacometric approach in rats	4
Meeting report: DMDG peptide and oligonucleotide ADME workshop 2024	4
Pharmacokinetics of intranasal drugs, still a missed opportunity?	4
How predictive are isolated perfused liver data of in vivo hepatic clearance? A meta-analysis of isolated perfused rat liver data	4
Human and nonclinical disposition of [¹⁴C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection	4
EP300/HIF-1 pathway: the key to sacubitril valsartan sodium alleviating myocardial hypoxia injury	4
Perspectives on the use of machine learning for ADME prediction at AstraZeneca	4
Study of the urinary metabolites of 17ɑ-methyl-19-nortestosterone in human using gas chromatography – mass spectrometry. Preliminary results	4
Pharmacokinetics, tissue distribution, plasma protein binding rate and excretion of sinoacutine following intravenous administration in female and male Sprague-Dawley rats	4
Response to the comments raised by Fernando Tricta	4
In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor	4
The chlorophenoxy herbicide MCPA: a mechanistic basis for the observed differences in toxicological profile in humans and rats versus dogs	4