Xenobiotica

Article	Citations
One small step in time, one giant leap for DMPK kind – a CRO perspective of the evolving core discipline of drug development	22
Academic foreign compound metabolism – ‘ quo vadis ’?	20
Developmental stage and infection status may affect drug distribution in the prostate of rats	19
In vitro hepatic metabolism of the natural product quebecol	16
Meeting report: oligonucleotide ADME workshop	14
Diisononyl phthalate down-regulates the expression of antioxidant genes NFE2L2 , TXN , and TXNRD2 , while d	12
Utility of preclinical species for uncertainty assessment and correction of prediction of human volume of distribution using the Rodgers-Lukacova model	12
Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver	11
Nrf2 signaling pathway studies in Drosophila melanogaster : parallel roles in human health and insect environmental responses	10
Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2	10
An In silico model-based feasibility assessment of erlotinib long-acting injectable formulation for the management of metastatic non-small cell lung cancer	9
Notable drug-drug interaction between omeprazole and voriconazole in CYP2C19 *1 and *2 (rs4244285, 681G>A) alleles in vitro	9
Formulation of apigenin-loaded solid lipid nanoparticles: characterisation, molecular docking, and anticancer assay	9
Preparation, characterisation, pharmacokinetics and distribution of esculin microspheres administered via intravitreal injection into rabbit brain	9
In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor	9
Apigenin derivatives as promising norovirus RdRp inhibitors: insights from in silico docking and molecular dynamics studies	9
The protective effect of linalool against carbon tetrachloride-induced testicular toxicity in rats	9
Methyl mercury pharmacokinetics in man: a five-compartment hybrid model	8
Comparisons between human and rodent hepatic glutathione S-Transferase activities reveal sex and species differences	8
Machine learning-driven bioavailability prediction in early-stage drug development: a KNIME-based computational workflow for digital health applications	8
Three methods to optimise polymyxin B dosing using estimated AUC after first dose: validation with the data generated by Monte Carlo simulation	8
Effect of genetic polymorphisms on the pharmacokinetics of gefitinib in healthy Chinese volunteers	8
Arctigenin-induced erythrocyte membrane remodelling is mediated through calcium influx, metabolic collapse, and casein kinase 1α	8
Power of integrating PBPK with PBBM (PBPK-BM): a single model predicting food effect, gender impact, drug-drug interactions and bioequivalence in fasting & fed conditions	8
The effect of ARVs on the MEKKK1 gene promoter, inflammatory cytokine expression and signalling in acute treated Jurkat T cells	8

Safflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics	7
Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P 1 modulator ponesimod	7
Renal tubular transporter-mediated interactions between mirogabalin and cimetidine in rats	7
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-M	7
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle	7
Prediction of the neurotoxic mechanisms of the pesticide phorate using network toxicology, molecular docking, and molecular dynamics simulation	7
New era in bioequivalence global harmonization through ICH M13 initiative: critical review on new concepts, alternative approaches for high-risk products	7
An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds	7
In vivo evaluation of pharmacokinetic drug–drug interactions between fluorinated pyrimidine anticancer drugs, 5-fluorouracil and capecitabin, and an anticoagulant, warfarin	7
Defining the enzymes of xenobiotic metabolism – a forlorn hope?	7
Development of eugenol-fortified fisetin-loaded nano-invasomes gel	6
2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A2	6
Experimental and computational models to investigate intestinal drug permeability and metabolism	6
Elucidation of clearance mechanism of TP0463518, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor: does a species difference in excretion routes exist between humans and animals?	6
Bioavailability and dose proportionality of a highly lipophilic phenolic antioxidant	6
Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir	6
Beyond cytotoxic potency: disposition features required to design ADC payload	6
The effects of genetic polymorphism on toxicity and pharmacokinetics of methotrexate in Egyptian adult patients with leukaemia or lymphoma	6
Nano-pharmacokinetics and pharmacodynamics of green-synthesized ZnO nanoparticles: a pathway to safer therapeutic applications	6
Interactions of organophosphorus pesticides with ATP-binding cassette (ABC) drug transporters	6
Preclinical assessment of the PI3Kα selective inhibitor inavolisib and prediction of its pharmacokinetics and efficacious dose in human	6
Mechanism of Black American Ginseng saponins in ameliorating memory dysfunction in aging mice by activating the BDNF/PI3K/AKT/CREB pathway	6
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study	6
Effectiveness of pain care intervention combined with traditional Chinese medicine care in the perioperative care of patients with urinary stones	6
Pharmacokinetics and multi-peak phenomenon analysis of novel anti-Parkinson’s drug FLZ after multi-dose in cynomolgus monkeys	6
Effects of tyrosine kinase inhibitors used for the treatment of non-small cell lung carcinoma on cytochrome P450 2J2 activities	6
Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation	5
Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats	5
Human and nonclinical disposition of [14C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection	5
Characterisation of seven medications approved for attention-deficit/hyperactivity disorder usingin vitromodels of hepatic metabolism	5
Monomethyl auristatin E (MMAE), a payload for multiple antibody drug conjugates (ADCs), demonstrates differential red blood cell partitioning across human and animal species	5
Meeting report of the 3rd European Biotransformation Workshop	5
Application of physiologically based pharmacokinetic models for therapeutic proteins and other novel modalities	5
Pharmacokinetics of intranasal drugs, still a missed opportunity?	5
Preface for special issue: “Emerging strategies, technologies, and approaches for the next generation ADCs”	5
Impact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats	5
Evobrutinib pathway to its major metabolite M463-2 and insights from a biotransformation and DDI perspective	5
Sanguinarine-induced proteomic changes in methicillin-resistant Staphylococcus aureus	5
The chlorophenoxy herbicide MCPA: a mechanistic basis for the observed differences in toxicological profile in humans and rats versus dogs	5
A population pharmacokinetic-pharmacodynamic model of navtemadlin, its glucuronide metabolite (M1) and serum macrophage inhibitory cykokine-1 (MIC-1)	4
Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration	4
Physiologically based pharmacokinetic (PBPK) modelling and simulation based integrative approach to assess natural product-drug interactions – effect of glycyrrhetinic acid on quetiapine	4
Drug-drug interaction between danshensu and irbesartan and its potential mechanism	4
The impact of CYP3A5 , NR1I2 , and POR polymorphisms on tacrolimus dose-adjusted concentration and clinical	4
Potential influence of interleukin-6 -174G/C gene polymorphism on kidney graft function and tacrolimus dose requirements: five-year follow-up	4
Studies addressing potential bioactivation and genotoxicity liabilities of the N -nitroso derivative of the antidepressant paroxetine	4
Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury	4
How predictive are isolated perfused liver data of in vivo hepatic clearance? A meta-analysis of isolated perfused rat liver data	4
Use of a machine learning approach to estimate pathobiological effects of crack cocaine administration in rats	4
In vitro evaluation of norwogonin as a potential inhibitor of cytochrome P450 forms 3A4, 2D6, and 2C9	4

EP300/HIF-1 pathway: the key to sacubitril valsartan sodium alleviating myocardial hypoxia injury	4
Perspectives on the use of machine learning for ADME prediction at AstraZeneca	4
The mitochondrial protective mechanisms mediated by SGLT2i: from molecular basis to clinical implications	4
Sodium dodecylbenzene sulphonate (SDBS) present in detergents: action on the gills, skin, and blood of D. rerio fish	4
A physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model for the insecticide dimethoate	4
Inorganic mercury pharmacokinetics in man: a hybrid model	4
Meeting report: DMDG peptide and oligonucleotide ADME workshop 2024	4
Predictive marker for exposure-driven haematological toxicity of tegafur-uracil and proposed modified-dosage regimen by pharmacometric approach in rats	4
Study of the urinary metabolites of 17ɑ-methyl-19-nortestosterone in human using gas chromatography – mass spectrometry. Preliminary results	4
Pharmacokinetics, metabolism and excretion of radiolabeled fostemsavir administered with or without ritonavir in healthy male subjects	4
Preclinical pharmacokinetics, metabolism, and disposition of NXE0041178, a novel orally bioavailable agonist of the GPR52 receptor with potential for treatment of schizophrenia and related psychiatric	3
Biochemical responses of the mussel Perna perna after exposure to environmental concentrations of the UV filter Benzophenone-3	3
Analysis of the therapeutic potential of astragalin: insights into target interactions and mechanisms	3
A discovery biotransformation strategy: combining in silico tools with high-resolution mass spectrometry and software-assisted data analysis for high-throughput metabolism	3
Potential application of mass spectrometry imaging in pharmacokinetic studies	3
Approaches to improve the translation of safety, pharmacokinetics and therapeutic index of ADCs	3
Determination of enzymatic kinetics of metabolism of dimethoate and omethoate in rats and humans	3
Effect of berberine on pharmacokinetics and pharmacodynamics of atorvastatin in hyperlipidemia rats	3
Bidirectional relationship between statins and the gut microbiota: implications for cardiovascular health, diabetes, and cancer	3
Study on the transport and internalisation mechanism of dietary supplement nattokinase in the small intestine using animal and Caco-2 cell monolayer models	3
Meeting report: DMDG peptide and oligonucleotide ADME workshop 2022	3
The metabolism of the dual orexin receptor antagonist daridorexant	3
Feature-based molecular networking updates the in vitro metabolic characterisation of fenbendazole across species	3
N, N -dimethyltryptamine forms oxygenated metabolites via CYP2D6 - an in vitro investigation	3
Unravelling the toxic potential of imidacloprid and chlorothalonil in thyroid, liver, and kidney of rats: a combined experimental and computational investigations	3
Behavioural toxicodynamics and kinetic profiling of PCB congeners in Swiss Albino mouse dosed with Aroclor 1232 through inhalational route: a pivotal risk assessment study	3
Calycosin improves insulin resistance by regulating the hsa-miR-324-3p/AKT pathway to inhibit FOXO3a nuclear transfer	3
Green synthesis of Zinc Oxide nanoflowers using camellia sinensis extract and evaluation of their xenobiotic-like cellular, apoptotic, and inflammatory r	3
Qualitative and quantitative status of cytochrome P450s after the administration of a liposomal platelet substitute in rat liver	3
Prediction of pharmacokinetics of an anaplastic lymphoma kinase inhibitor in rat and monkey: application of physiologically based pharmacokinetic model as an alternative tool to minimise animal studie	3
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs	3
Preclinical pharmacokinetics, CYP phenotyping, and tissue distribution study of novel anti-breast cancer candidate S-011-1559	3
Benzophenone-3 (oxybenzone) in zebrafish: histopathological and oxidative stress analysis	3
Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models	3
Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K	3
Effect of tubeimoside I on the activity of cytochrome P450 enzymes in human liver microsomes	3
Thank you to reviewers	3
Investigation of pharmacokinetic properties of a PEGylated bilirubin nanoparticle in male Sprague-Dawley rats using liquid chromatography-quadrupole time-of-flight mass spectrometry	3
Permethrin disrupts antioxidant defense responses in Litopenaeus vannamei	3
Justification of widened dissolution specifications of an extended-release product using physiologically based biopharmaceutics modeling	2
Comprehensive characterization and optimization of Caco-2 cells enabled the development of a miniaturized 96-well permeability assay	2
Mass balance and metabolite profiling of 14 C-Zalunfiban in humans following single-dose subcutaneous administration	2
Exploring ethanol’s toxicity in the oral submucosa: chronic exposure versus abstinence in C57BL/6 mice	2
Dolutegravir metabolism: impact of genetic variations on uridine diphosphate glucuronosyltransferase subfamilies	2
Fluoxetine as an antidepressant agent induces directly deleterious effects on rat isolated pancreatic mitochondria: ameliorative role of betanin	2
Effects of different doses of dexmedetomidine combined with stellate ganglion block in patients undergoing laparoscopic radical resection of colorectal cancer	2
A translational strategy employing physiologically based modelling to predict the pharmacological active dose of RO7119929, an oral prodrug of a targeted cancer immunotherapy TLR7 agonist	2
Meeting report: DMPK optimisation strategies and quantitative translational PKPD frameworks to predict human PK and efficacious dose of targeted protein degraders	2
Emerging conjugation strategies and protein engineering technologies aim to improve ADCs in the fight against cancer	2
The orexin 1-selective receptor antagonist nivasorexant is a time-dependent inhibitor of CYP2C19 and CYP3A4	2
Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development	2
Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p -nitrophenol	2
Comparative study on ABCB1-dependent efflux of anthracyclines and their metabolites: consequences for cancer resistance	2
Physiologically based pharmacokinetic modelling to predict drug–drug interactions for encorafenib. Part I. Model building, validation, and prospective predictions with enzyme inhibitors, inducers, and	2
Prediction of the liver safety profile of a first-in-class myeloperoxidase inhibitor using quantitative systems toxicology modeling	2
Mechanism-based inactivation of cytochromes P450: implications in drug interactions and pharmacotherapy	2
Evaluation of the non-linearity of NA808 in liver not reflected in plasma using a rat pharmacokinetic study and PBPK modelling	2
Use of stable isotope labeled (SIL) antibodies in cassette dosing to improve pharmacokinetics screening efficiency of ADCs with novel cytotoxic payloads	2
Effects of ABCG2 421C > A genetic polymorphism on the pharmacokinetics of rivaroxaban in healthy Chinese subjects	2
Investigation on the in vitro metabolism of bicyclol using liver microsomes, hepatocytes and human recombinant cytochrome P450 enzymes	2
Metabolite characterisation of the peptide–drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS	2
Pharmacokinetic interaction between pachymic acid and tacrolimus and its potential mechanisms in rats	2
Synthesis and evaluation of indomethacin prodrugs with a diester structure that are metabolically activated by human carboxylesterases	2
Exposure to crack cocaine induces genotoxicity and degenerative changes in multiple organs of Wistar rats	2
Metabolism and disposition of zamicastat in rats	2
In vitro anti-glucocorticoid osteoporosis effect of Serfurosterone A and its intestinal absorption characteristics	2
MRM-driven metabolomic workflow for early detection of antibiotic-triggered sub-lethal toxicity using Q-TRAP and zebrafish model	2
Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver	2
In vitro and in vivo metabolic profiling of PD105, a PI3Kδ inhibitor, using UHPLC-Q-Exactive plus-MS	2
Mechanism-based inactivation of cytochrome P450 3A by evodol	2
Identification, structural elucidation and nonclinical characterisation of oxMET1: a further major metabolite of xevinapant?	2
The pharmacokinetics of dabigatran in a rat model of hyperlipidaemia induced by poloxamer 407	2
Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death	2
Exploring the pharmacokinetics of second-generation cephalosporin, cefaclor: a systematic review in healthy and diseased populations	1
In vitro safety evaluation of (6-methoxy-9-oxo-9 H -xanthen-2-yl)methyl ( E )-3-(2,4-dimethoxyphenyl)acrylate (K-116) –	1
Determination of free fraction (fu) of compounds by flux dialysis using the rapid equilibrium dialysis (RED) device: establishing empirical permeability for rapid estimation	1
Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations	1
Changes in the expression of drug-metabolising enzymes and drug transporters in mice with collagen antibody-induced arthritis	1
Do differences in cell lines and methods used for calculation of IC50 values influence categorisation of drugs as P-glycoprotein substrates and inhibitors?	1
The impact of ibuprofen on valproic acid plasma concentration in pediatric patients	1

In vitro and in vivo studies on the metabolism and pharmacokinetics of the selective gut microbial β-glucuronidase targeting compound Inh 1	1
Effects of pharmacogenetics on pharmacokinetics and toxicity of doxorubicin in Egyptian breast cancer patients	1
Meeting report of the 5th European Biotransformation Workshop	1
Comparative metabolism of THCA and THCV using UHPLC-Q-Exactive Orbitrap-MS	1
Rehmannioside A inhibits the activity of CYP3A4, 2C9 and 2D6 in vitro	1
The metabolic activation of and platelet response to vicagrel vary with P-glycoprotein deficiency, rather than P-glycoprotein inhibition, in mice	1
Regulatory effect of atorvastatin combined with berberine on PI3K/AKT/FoxO1 signaling pathway in rats with hyperlipidaemia	1
Impact of Terminalia ivorensis on drug metabolising and antioxidant enzyme activities, hepatotoxicity and genotoxicity in human liver cells	1
In silico analysis of nicotine’s molecular targets in Parkinson’s disease	1
Quantitative prediction of drug-drug interactions arising from CYP3A4 induction using chimeric mice with humanized liver	1
α-Hederin inhibits osteosarcoma progression by triggering ferroptosis and disrupting mitochondrial function via PI3K/AKT signalling	1
Metabolite profiling and identification of enzymes responsible for the metabolism of hirsutine, a major alkaloid from Uncaria rhynchophylla	1
Through a computer monitor darkly: artificial intelligence in absorption, distribution, metabolism and excretion science	1
Mass balance study of [14C]SHR0302, a selective and potent JAK1 inhibitor in humans	1
Clinical pharmacokinetics of cefixime: a systematic review	1
Pharmacokinetics and tissue distribution of intranasal administration of rapamycin in rats	1
Crack cocaine exposure leads to developmental alterations and mitochondrial dysfunction in the Drosophila melanogaster model	1
Prediction of combination effect of quinidine on the pharmacokinetics of tipepidine using a physiologically based pharmacokinetic model	1
Two curcumin analogs inhibited the function and protein expression of breast cancer resistance protein: in vitro and in vivo studies	1
A general perspective for the conduct of radiolabelled distribution, metabolism, and excretion studies for antibody-drug conjugates	1
Absorption, metabolism, and excretion of [14C]-sebetralstat (KVD900) following a single oral dose in healthy male participants	1
4,4’-Methylene diphenyl diisocyanate exposure induces expression of alternatively activated macrophage-associated markers and chemokines partially through Krüppel-like factor 4 mediated signaling in m	1
Comparing the pharmacokinetics and organ/tissue distribution of anti-methicillin-resistant Staphylococcus aureus agents using a rat model of sepsis	1
In vitro-in vivo extrapolation of intrinsic clearance based on data from human hepatocyte spheroids – a case study with the low-clearance drug xevinapant	1
Danazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats	1
Cytotoxic effects of flurbiprofen on rat adipose-derived stem cells	1
A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin-cleavable ADC linkers	1
Indirubin mediates adverse intestinal reactions in guinea pigs by downregulating the expression of AchE through AhR	1
The 50th anniversary of the DMDG	1
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human	1
Protective effect of carvacrol in a cardiac myoblast cell model of myocardial ischaemia-reperfusion injury	1
Inhibition of YAP can down-regulate NLRP3 inflammasome and improve anti-tuberculosis drug-induced liver injury	1
CYP-catalysed cycling of clozapine and clozapine- N -oxide promotes the generation of reactive oxygen species in vitro	1
Fluorescent dyes as functional probes for studying drug-transporting solute carriers	1
Toxicokinetic and mass balance of morpholine in rats	1
Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies	1
Model-based steady state pharmacokinetic predictions using high throughput cassette infusion approach in mice	1
Optimising pirfenidone dosage regimens in idiopathic pulmonary fibrosis: towards a guide for personalised treatment	1
Development and validation of a highly sensitive and selective LC-MS/MS method for the determination of 15-hydroxylubiprostone in human plasma: application to a pharmacokinetic study in healthy Chines	1
Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets	1
Relevance of gene polymorphisms of NAT2 and NR1I2 to anti-tuberculosis drug-induced hepatotoxicity	1
Correction	1
Assessment of cytochrome P450 induction in canine intestinal organoid models	1
ADME properties of CHF6366, a novel bi-functional M3 muscarinic receptor antagonist and ß2 adrenoceptor agonist (MABA) radiolabelled at both functional moieties	1
Hydrogen sulfide replenishment ameliorates impaired platelet response to clopidogrel in mice with experimental diabetes mellitus	1
Pharmacokinetics of the novel 5-HT 4 receptor agonist, DA-6886, in dogs	1
MicroRNA-mediated Krüppel-like factor 4 upregulation induces alternatively activated macrophage-associated marker and chemokine transcription in 4,4’-methylene diphenyl diisocyanate exposed macrophage	1
Combination of losartan and puerarin induced pharmacokinetic interaction in hypertension rats enhances the antihypertensive effect of losartan	1
Preclinical metabolism and disposition of [ 14 C]GFH009, a novel selective CDK9 inhibitor	1
The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro	1
Use of selective substrates and inhibitors to rapidly characterise batches of cryopreserved primary human hepatocytes for assessment of active uptake liability in drug discovery and development	1
The metabolism of the orexin-1 selective receptor antagonist nivasorexant	1
Population pharmacokinetics of mycophenolic acid and dose optimisation in adult Chinese kidney transplant recipients	1
Teratogenicity is more likely a function of primary and secondary pharmacology than caused by chemically reactive metabolites: a critical evaluation of 40 years of scientific research	1