Xenobiotica

Article	Citations
One small step in time, one giant leap for DMPK kind – a CRO perspective of the evolving core discipline of drug development	24
Academic foreign compound metabolism – ‘ quo vadis ’?	23
In vitro hepatic metabolism of the natural product quebecol	19
Meeting report: oligonucleotide ADME workshop	16
Diisononyl phthalate down-regulates the expression of antioxidant genes NFE2L2 , TXN , and TXNRD2 , while d	14
Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver	13
Nrf2 signaling pathway studies in Drosophila melanogaster : parallel roles in human health and insect environmental responses	12
In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor	12
Formaldehyde directly induces cytotoxicity in human lymphocytes through ROS formation, mitochondrial/lysosomal destruction and oxidative stress; analysis of the protective effects of crocin	11
An In silico model-based feasibility assessment of erlotinib long-acting injectable formulation for the management of metastatic non-small cell lung cancer	11
Apigenin derivatives as promising norovirus RdRp inhibitors: insights from in silico docking and molecular dynamics studies	10
Formulation of apigenin-loaded solid lipid nanoparticles: characterisation, molecular docking, and anticancer assay	10
Developmental stage and infection status may affect drug distribution in the prostate of rats	10
The protective effect of linalool against carbon tetrachloride-induced testicular toxicity in rats	10
Methyl mercury pharmacokinetics in man: a five-compartment hybrid model	9
Power of integrating PBPK with PBBM (PBPK-BM): a single model predicting food effect, gender impact, drug-drug interactions and bioequivalence in fasting & fed conditions	9
Comparisons between human and rodent hepatic glutathione S-Transferase activities reveal sex and species differences	9
Preparation, characterisation, pharmacokinetics and distribution of esculin microspheres administered via intravitreal injection into rabbit brain	9
Notable drug-drug interaction between omeprazole and voriconazole in CYP2C19 *1 and *2 (rs4244285, 681G>A) alleles in vitro	8
New era in bioequivalence global harmonization through ICH M13 initiative: critical review on new concepts, alternative approaches for high-risk products	8
The effect of ARVs on the MEKKK1 gene promoter, inflammatory cytokine expression and signalling in acute treated Jurkat T cells	8
Effect of genetic polymorphisms on the pharmacokinetics of gefitinib in healthy Chinese volunteers	8
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle	8
Arctigenin-induced erythrocyte membrane remodelling is mediated through calcium influx, metabolic collapse, and casein kinase 1α	8
Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P 1 modulator ponesimod	8

Machine learning-driven bioavailability prediction in early-stage drug development: a KNIME-based computational workflow for digital health applications	7
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-M	7
Renal tubular transporter-mediated interactions between mirogabalin and cimetidine in rats	7
Three methods to optimise polymyxin B dosing using estimated AUC after first dose: validation with the data generated by Monte Carlo simulation	7
An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds	7
2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A2	7
Steady-state pharmacokinetics of oral semaglutide using semi-mechanistic pharmacokinetic modelling and population simulations	7
Safflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics	7
Mechanism of Black American Ginseng saponins in ameliorating memory dysfunction in aging mice by activating the BDNF/PI3K/AKT/CREB pathway	7
Defining the enzymes of xenobiotic metabolism – a forlorn hope?	7
Tetrahydrouridine pre-treatment increases tissue exposure of 14 C-decitabine in mice	6
The effects of genetic polymorphism on toxicity and pharmacokinetics of methotrexate in Egyptian adult patients with leukaemia or lymphoma	6
Development of eugenol-fortified fisetin-loaded nano-invasomes gel	6
Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation	6
Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir	6
Effectiveness of pain care intervention combined with traditional Chinese medicine care in the perioperative care of patients with urinary stones	6
Preclinical assessment of the PI3Kα selective inhibitor inavolisib and prediction of its pharmacokinetics and efficacious dose in human	6
Experimental and computational models to investigate intestinal drug permeability and metabolism	6
Beyond cytotoxic potency: disposition features required to design ADC payload	6
Impact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats	6
Nano-pharmacokinetics and pharmacodynamics of green-synthesized ZnO nanoparticles: a pathway to safer therapeutic applications	6
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study	6
Prediction of the neurotoxic mechanisms of the pesticide phorate using network toxicology, molecular docking, and molecular dynamics simulation	6
Bioavailability and dose proportionality of a highly lipophilic phenolic antioxidant	6
Preface for special issue: “Emerging strategies, technologies, and approaches for the next generation ADCs”	6
Pharmacokinetics and multi-peak phenomenon analysis of novel anti-Parkinson’s drug FLZ after multi-dose in cynomolgus monkeys	6
Effects of tyrosine kinase inhibitors used for the treatment of non-small cell lung carcinoma on cytochrome P450 2J2 activities	5
Sanguinarine-induced proteomic changes in methicillin-resistant Staphylococcus aureus	5
Preparation of berberine micelles and its anti-skin damage in hyperglycemia mice	5
Evobrutinib pathway to its major metabolite M463-2 and insights from a biotransformation and DDI perspective	5
Application of physiologically based pharmacokinetic models for therapeutic proteins and other novel modalities	5
Human and nonclinical disposition of [14C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection	5
Monomethyl auristatin E (MMAE), a payload for multiple antibody drug conjugates (ADCs), demonstrates differential red blood cell partitioning across human and animal species	5
Sodium dodecylbenzene sulphonate (SDBS) present in detergents: action on the gills, skin, and blood of D. rerio fish	5
Exploring the clinical pharmacokinetics and pharmacodynamics of third-generation cephalosporin, a cefotaxime: a systematic review	5
Meeting report of the 3rd European Biotransformation Workshop	5
EP300/HIF-1 pathway: the key to sacubitril valsartan sodium alleviating myocardial hypoxia injury	4
Meeting report: DMDG peptide and oligonucleotide ADME workshop 2024	4
A physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model for the insecticide dimethoate	4
Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury	4
Use of a machine learning approach to estimate pathobiological effects of crack cocaine administration in rats	4
The mitochondrial protective mechanisms mediated by SGLT2i: from molecular basis to clinical implications	4
The impact of CYP3A5 , NR1I2 , and POR polymorphisms on tacrolimus dose-adjusted concentration and clinical	4
An LC-MS/MS method for simultaneous quantification of six components of Angelicae pubescentis radix and systematic evaluation of A	4
Pharmacokinetics of intranasal drugs, still a missed opportunity?	4
Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration	4
Inorganic mercury pharmacokinetics in man: a hybrid model	4
Perspectives on the use of machine learning for ADME prediction at AstraZeneca	4
Study of the urinary metabolites of 17ɑ-methyl-19-nortestosterone in human using gas chromatography – mass spectrometry. Preliminary results	4
Potential influence of interleukin-6 -174G/C gene polymorphism on kidney graft function and tacrolimus dose requirements: five-year follow-up	4

How predictive are isolated perfused liver data of in vivo hepatic clearance? A meta-analysis of isolated perfused rat liver data	4
Physiologically based pharmacokinetic (PBPK) modelling and simulation based integrative approach to assess natural product-drug interactions – effect of glycyrrhetinic acid on quetiapine	4
In vitro evaluation of norwogonin as a potential inhibitor of cytochrome P450 forms 3A4, 2D6, and 2C9	4
Drug-drug interaction between danshensu and irbesartan and its potential mechanism	4
Studies addressing potential bioactivation and genotoxicity liabilities of the N -nitroso derivative of the antidepressant paroxetine	4
Green synthesis of Zinc Oxide nanoflowers using camellia sinensis extract and evaluation of their xenobiotic-like cellular, apoptotic, and inflammatory r	3
Calycosin improves insulin resistance by regulating the hsa-miR-324-3p/AKT pathway to inhibit FOXO3a nuclear transfer	3
Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models	3
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs	3
N, N -dimethyltryptamine forms oxygenated metabolites via CYP2D6 - an in vitro investigation	3
Effect of berberine on pharmacokinetics and pharmacodynamics of atorvastatin in hyperlipidemia rats	3
Benzophenone-3 (oxybenzone) in zebrafish: histopathological and oxidative stress analysis	3
Thank you to reviewers	3
Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K	3
Bidirectional relationship between statins and the gut microbiota: implications for cardiovascular health, diabetes, and cancer	3
The metabolism of the dual orexin receptor antagonist daridorexant	3
Approaches to improve the translation of safety, pharmacokinetics and therapeutic index of ADCs	3
Resveratrol may mitigate the proliferation and migration of hypertrophic scars via miR-1290/ADAMTS8	3
Biochemical responses of the mussel Perna perna after exposure to environmental concentrations of the UV filter Benzophenone-3	3
Behavioural toxicodynamics and kinetic profiling of PCB congeners in Swiss Albino mouse dosed with Aroclor 1232 through inhalational route: a pivotal risk assessment study	3
Unravelling the toxic potential of imidacloprid and chlorothalonil in thyroid, liver, and kidney of rats: a combined experimental and computational investigations	3
Determination of enzymatic kinetics of metabolism of dimethoate and omethoate in rats and humans	3
Effect of tubeimoside I on the activity of cytochrome P450 enzymes in human liver microsomes	3
Modulatory role of fucoidan against monosodium glutamate-induced reproductive and hepatorenal toxicity in adult male rats	3
In vitro and in vivo preclinical pharmacokinetic characterisation of ulacamten, a small molecule cardiac myosin inhibitor for the treatment of heart failure with preserved ejection fraction (HFpEF)	3
A discovery biotransformation strategy: combining in silico tools with high-resolution mass spectrometry and software-assisted data analysis for high-throughput metabolism	3
Lipid dysregulation in chronic diseases: systems biology and omics perspectives	3
Investigation of pharmacokinetic properties of a PEGylated bilirubin nanoparticle in male Sprague-Dawley rats using liquid chromatography-quadrupole time-of-flight mass spectrometry	3
Potential application of mass spectrometry imaging in pharmacokinetic studies	3
Permethrin disrupts antioxidant defense responses in Litopenaeus vannamei	2
Analysis of the therapeutic potential of astragalin: insights into target interactions and mechanisms	2
Meeting report: DMDG peptide and oligonucleotide ADME workshop 2022	2
Prediction of the liver safety profile of a first-in-class myeloperoxidase inhibitor using quantitative systems toxicology modeling	2
Mass balance and metabolite profiling of 14 C-Zalunfiban in humans following single-dose subcutaneous administration	2
Metabolism and disposition of zamicastat in rats	2
Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver	2
Detection of hard electrophilic reactive metabolites formed from alicyclic amines using glutathione trapping	2
The orexin 1-selective receptor antagonist nivasorexant is a time-dependent inhibitor of CYP2C19 and CYP3A4	2
Effects of ABCG2 421C > A genetic polymorphism on the pharmacokinetics of rivaroxaban in healthy Chinese subjects	2
Metabolite characterisation of the peptide–drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS	2
Meeting report: DMPK optimisation strategies and quantitative translational PKPD frameworks to predict human PK and efficacious dose of targeted protein degraders	2
Preclinical pharmacokinetics, metabolism, and disposition of NXE0041178, a novel orally bioavailable agonist of the GPR52 receptor with potential for treatment of schizophrenia and related psychiatric	2
Investigation on the in vitro metabolism of bicyclol using liver microsomes, hepatocytes and human recombinant cytochrome P450 enzymes	2
Feature-based molecular networking updates the in vitro metabolic characterisation of fenbendazole across species	2
Emerging conjugation strategies and protein engineering technologies aim to improve ADCs in the fight against cancer	2
Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development	2
Evaluation of the non-linearity of NA808 in liver not reflected in plasma using a rat pharmacokinetic study and PBPK modelling	2
In vitro anti-glucocorticoid osteoporosis effect of Serfurosterone A and its intestinal absorption characteristics	2
Pharmacokinetics, mass balance and metabolic profiling of resmetirom in healthy subjects and nonclinical metabolism and disposition	2
Computational analysis of dual targeting of β 1 -adrenergic and AT 1 receptors by bisoprolol fumar	2
Identification, structural elucidation and nonclinical characterisation of oxMET1: a further major metabolite of xevinapant?	2
Use of stable isotope labeled (SIL) antibodies in cassette dosing to improve pharmacokinetics screening efficiency of ADCs with novel cytotoxic payloads	2
Effects of different doses of dexmedetomidine combined with stellate ganglion block in patients undergoing laparoscopic radical resection of colorectal cancer	2
In vitro and in vivo metabolic profiling of PD105, a PI3Kδ inhibitor, using UHPLC-Q-Exactive plus-MS	2
Study on the transport and internalisation mechanism of dietary supplement nattokinase in the small intestine using animal and Caco-2 cell monolayer models	2
Qualitative and quantitative status of cytochrome P450s after the administration of a liposomal platelet substitute in rat liver	2
A translational strategy employing physiologically based modelling to predict the pharmacological active dose of RO7119929, an oral prodrug of a targeted cancer immunotherapy TLR7 agonist	2
Exploring ethanol’s toxicity in the oral submucosa: chronic exposure versus abstinence in C57BL/6 mice	2
The pharmacokinetics of dabigatran in a rat model of hyperlipidaemia induced by poloxamer 407	2
Physiologically based pharmacokinetic modelling to predict drug–drug interactions for encorafenib. Part I. Model building, validation, and prospective predictions with enzyme inhibitors, inducers, and	2
Mechanism-based inactivation of cytochromes P450: implications in drug interactions and pharmacotherapy	2
MRM-driven metabolomic workflow for early detection of antibiotic-triggered sub-lethal toxicity using Q-TRAP and zebrafish model	2
Dolutegravir metabolism: impact of genetic variations on uridine diphosphate glucuronosyltransferase subfamilies	2
Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death	2
Mechanism-based inactivation of cytochrome P450 3A by evodol	2
Fluoxetine as an antidepressant agent induces directly deleterious effects on rat isolated pancreatic mitochondria: ameliorative role of betanin	2
Prediction of pharmacokinetics of an anaplastic lymphoma kinase inhibitor in rat and monkey: application of physiologically based pharmacokinetic model as an alternative tool to minimise animal studie	2
The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro	1
Impact of Terminalia ivorensis on drug metabolising and antioxidant enzyme activities, hepatotoxicity and genotoxicity in human liver cells	1
Comparative study on ABCB1-dependent efflux of anthracyclines and their metabolites: consequences for cancer resistance	1
Inhibition of YAP can down-regulate NLRP3 inflammasome and improve anti-tuberculosis drug-induced liver injury	1
Optimising pirfenidone dosage regimens in idiopathic pulmonary fibrosis: towards a guide for personalised treatment	1
AS-IV’s protective potential against inflammatory injury via miR-320b/PTEN axis in acute ischaemic stroke	1
α-Hederin inhibits osteosarcoma progression by triggering ferroptosis and disrupting mitochondrial function via PI3K/AKT signalling	1
Protective effect of carvacrol in a cardiac myoblast cell model of myocardial ischaemia-reperfusion injury	1
Rehmannioside A inhibits the activity of CYP3A4, 2C9 and 2D6 in vitro	1
Fluorescent dyes as functional probes for studying drug-transporting solute carriers	1
Danazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats	1
Through a computer monitor darkly: artificial intelligence in absorption, distribution, metabolism and excretion science	1
Therapeutic potential of Zanthoxylum rhetsa (roxb.) DC.: a systematic review of bioactive drug-Like compounds and natural drug leads	1

Toxicokinetic and mass balance of morpholine in rats	1
Crack cocaine exposure leads to developmental alterations and mitochondrial dysfunction in the Drosophila melanogaster model	1
In vitro and in vivo studies on the metabolism and pharmacokinetics of the selective gut microbial β-glucuronidase targeting compound Inh 1	1
Indirubin mediates adverse intestinal reactions in guinea pigs by downregulating the expression of AchE through AhR	1
Regulatory effect of atorvastatin combined with berberine on PI3K/AKT/FoxO1 signaling pathway in rats with hyperlipidaemia	1
Preclinical metabolism and disposition of [ 14 C]GFH009, a novel selective CDK9 inhibitor	1
Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p -nitrophenol	1
Quantitative prediction of drug-drug interactions arising from CYP3A4 induction using chimeric mice with humanized liver	1
Synthesis and evaluation of indomethacin prodrugs with a diester structure that are metabolically activated by human carboxylesterases	1
Prediction of combination effect of quinidine on the pharmacokinetics of tipepidine using a physiologically based pharmacokinetic model	1
Clinical pharmacokinetics of cefixime: a systematic review	1
Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations	1
Teratogenicity is more likely a function of primary and secondary pharmacology than caused by chemically reactive metabolites: a critical evaluation of 40 years of scientific research	1
Comparative metabolism of THCA and THCV using UHPLC-Q-Exactive Orbitrap-MS	1
The metabolism of the orexin-1 selective receptor antagonist nivasorexant	1
Meeting report of the 6th European Biotransformation Workshop	1
ADME properties of CHF6366, a novel bi-functional M3 muscarinic receptor antagonist and ß2 adrenoceptor agonist (MABA) radiolabelled at both functional moieties	1
Justification of widened dissolution specifications of an extended-release product using physiologically based biopharmaceutics modeling	1
Determination of free fraction (fu) of compounds by flux dialysis using the rapid equilibrium dialysis device: establishing empirical permeability for rapid estimation	1
Pharmacokinetics and tissue distribution of intranasal administration of rapamycin in rats	1
A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin-cleavable ADC linkers	1
Mechanism of notoginsenoside R1 in alleviating intervertebral disc degeneration: an experimental and network pharmacological analysis based on ferroptosis and autophagy genes	1
In silico analysis of nicotine’s molecular targets in Parkinson’s disease	1
Effects of pharmacogenetics on pharmacokinetics and toxicity of doxorubicin in Egyptian breast cancer patients	1
The 50th anniversary of the DMDG	1
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human	1
Pharmacokinetic interaction between pachymic acid and tacrolimus and its potential mechanisms in rats	1
Two curcumin analogs inhibited the function and protein expression of breast cancer resistance protein: in vitro and in vivo studies	1
Population pharmacokinetics of mycophenolic acid and dose optimisation in adult Chinese kidney transplant recipients	1
A high-throughput LC-MS/MS method for simultaneous determination of lumateperone and its four metabolites in human plasma: application to a clinical trial	1
In vitro safety evaluation of (6-methoxy-9-oxo-9 H -xanthen-2-yl)methyl ( E )-3-(2,4-dimethoxyphenyl)acrylate (K-116) –	1
Model-based steady state pharmacokinetic predictions using high throughput cassette infusion approach in mice	1
Metabolite profiling and identification of enzymes responsible for the metabolism of hirsutine, a major alkaloid from Uncaria rhynchophylla	1
Pharmacokinetics of the novel 5-HT 4 receptor agonist, DA-6886, in dogs	1
Exploring the pharmacokinetics of second-generation cephalosporin, cefaclor: a systematic review in healthy and diseased populations	1
Correction	1
Exposure to crack cocaine induces genotoxicity and degenerative changes in multiple organs of Wistar rats	1
LC-PDA & LC-MS/MS approach of Daprodustat: forced degradation study	1
CYP-catalysed cycling of clozapine and clozapine- N -oxide promotes the generation of reactive oxygen species in vitro	1
Meeting report of the 5th European Biotransformation Workshop	1
A general perspective for the conduct of radiolabelled distribution, metabolism, and excretion studies for antibody-drug conjugates	1
Combination of losartan and puerarin induced pharmacokinetic interaction in hypertension rats enhances the antihypertensive effect of losartan	1
In vitro-in vivo extrapolation of intrinsic clearance based on data from human hepatocyte spheroids – a case study with the low-clearance drug xevinapant	1