Xenobiotica

Article	Citations
Mechanism-based inactivation of cytochrome P450 3A by evodol	25
Intracellular activation of 4-hydroxycyclophosphamide into a DNA-alkylating agent in human leucocytes	16
Optimising pirfenidone dosage regimens in idiopathic pulmonary fibrosis: towards a guide for personalised treatment	15
Oxidative metabolism of razuprotafib (AKB-9778), a sulfamic acid phosphatase inhibitor, in human microsomes and recombinant human CYP2C8 enzyme	15
Inorganic mercury pharmacokinetics in man: a hybrid model	15
Dolutegravir metabolism: impact of genetic variations on uridine diphosphate glucuronosyltransferase subfamilies	13
In vitro and in vivo metabolic profiling of PD105, a PI3Kδ inhibitor, using UHPLC-Q-Exactive plus-MS	12
Identification of in vivo metabolites of a potential anti-rheumatoid arthritis compound, the quinazolinone derivative PD110, using ultra-high performance liquid chromatography coupled with Q-Exactive	11
Meeting report of the second European biotransformation workshop	11
Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2	9
A general perspective for the conduct of radiolabelled distribution, metabolism, and excretion studies for antibody-drug conjugates	9
Emerging conjugation strategies and protein engineering technologies aim to improve ADCs in the fight against cancer	9
Hypothesis of using albumin to improve drug efficacy in cancers accompanied by hypoalbuminemia	9
Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase	8
Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration	8
Prevalence of SLCO1B1 single nucleotide variations and their association with hypercholesterolaemia in hypercholesterolemic patients in Gauteng, South Africa	8
Association between pharmacokinetics of lenvatinib in healthy subjects and genetic polymorphisms of ABCB1 3435C>T and ABCB1 2677G>T/A	8
Development of a physiologically based pharmacokinetic model for levetiracetam in patients with renal impairment to guide dose adjustment based on steady-state peak/trough concentrations	8
Human keratinocyte response to 4,4’-methylene diphenyl diisocyanate-glutathione conjugate exposure	7
Meeting report: oligonucleotide ADME workshop	7
How predictive are isolated perfused liver data of in vivo hepatic clearance? A meta-analysis of isolated perfused rat liver data	7
In vivo-in vitrocorrelation of antitumor activity of heat shock protein 90 (HSP90) inhibitors with a pharmacokinetics/pharmacodynamics analysis using NCI-N87 xenograft mice	7
Meeting report: DMPK optimisation strategies and quantitative translational PKPD frameworks to predict human PK and efficacious dose of targeted protein degraders	7
Toxicokinetic and mass balance of morpholine in rats	7
A systematic review of allometric scaling exponents for IgG mAbs	6

Pharmacokinetics, distribution and efficacy of triptolide PLGA microspheres after intra-articular injection in a rat rheumatoid arthritis model	6
Metabolism, pharmacokinetics and excretion of [14C]dimethyl fumarate in healthy volunteers: an example of xenobiotic biotransformation following endogenous metabolic pathways	6
Roles of cytochrome P450 2A6 in the oxidation of flavone, 4′-hydroxyflavone, and 4′-, 3′-, and 2′-methoxyflavones by human liver microsomes	6
In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor	6
Changes in the expression of drug-metabolising enzymes and drug transporters in mice with collagen antibody-induced arthritis	6
Absorption, metabolism, and excretion of [14C]-sebetralstat (KVD900) following a single oral dose in healthy male participants	6
One small step in time, one giant leap for DMPK kind – a CRO perspective of the evolving core discipline of drug development	6
Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of [ 14 C]aficamten following single oral dose administration to rats	6
A comprehensive analysis of six forms of cytochrome P450 2C (CYP2C) in pigs	6
Sex differences in the pharmacokinetics and tissue residues of Macleaya cordata extracts in rats	6
Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans	6
Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury	5
Population pharmacokinetics of sirolimus in Chinese adult liver transplant recipients: a retrospective study	5
Evaluation of urinary acetaminophen metabolites and its association with the genetic polymorphisms of the metabolising enzymes, and serum acetaminophen concentrations in preterm neonates with patent d	5
Pharmacokinetics, tissue distribution, plasma protein binding rate and excretion of sinoacutine following intravenous administration in female and male Sprague-Dawley rats	5
Evaluation of the effect of Bovis Calculus Artifactus on eight rat liver cytochrome P450 isozymes using LC-MS/MS and cocktail approach	5
Curcumin-loaded hydroxypropyl-β-cyclodextrin inclusion complex with enhanced dissolution and oral bioavailability for epilepsy treatment	5
Utility of preclinical species for uncertainty assessment and correction of prediction of human volume of distribution using the Rodgers-Lukacova model	5
Pomegranate peel polyphenols interaction with intestinal flora and its metabolic transformation	5
Use of stable isotope labeled (SIL) antibodies in cassette dosing to improve pharmacokinetics screening efficiency of ADCs with novel cytotoxic payloads	5
Assessment of P-glycoprotein function using canine intestinal organoid-derived epithelial interfaces	5
The common indoor air pollutant α-pinene is metabolised to a genotoxic metabolite α-pinene oxide	5
Vaginal administration of 17-alpha hydroxyprogesterone caproate appears to be safe in non-pregnant female rats and rabbits	5
Effects of CYP3A5 polymorphism and renal impairment on the drug interaction between venetoclax and fluconazole in acute myeloid leukaemia patients	5
Anastrozole and related glucuronic acid conjugate are electrophilic species	5
In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor	5
Developmental stage and infection status may affect drug distribution in the prostate of rats	5
A physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model for the insecticide dimethoate	5
Oral bioavailability and pharmacokinetics of esculetin following intravenous and oral administration in rats	4
A population pharmacokinetic-pharmacodynamic model of navtemadlin, its glucuronide metabolite (M1) and serum macrophage inhibitory cykokine-1 (MIC-1)	4
A translational strategy employing physiologically based modelling to predict the pharmacological active dose of RO7119929, an oral prodrug of a targeted cancer immunotherapy TLR7 agonist	4
Absorption, distribution, metabolism and excretion of 14C-Emvododstat following a single oral dose in rats and dogs	4
Curcumin and quercetin modify warfarin-induced regulation of porcine CYP1A2 and CYP3A expression and activity in vitro	4
Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver	4
Metabolism of the antipsychotic drug olanzapine by CYP3A43	4
Prospective prediction of plasma pharmacokinetics of a novel immune-modulating agent in cancer patients after intra-tumoral administration: translation from non-clinical species to humans	4
Effects of paeoniflorin on the activities and mRNA expression of rat CYP1A2, CYP2C11 and CYP3A1 enzymes in vivo	4
Clinical pharmacokinetics of cefixime: a systematic review	4
In vitro inhibition and induction of human liver cytochrome P450 enzymes by a novel anti-fibrotic drug fluorofenidone	4
Predicting routes of phase I and II metabolism based on quantum mechanics and machine learning	4
A cysteine trapping assay for risk assessment of reactive acyl CoA metabolites	4
In vitro hepatic metabolism of the natural product quebecol	4
In silico models to predict tubular secretion or reabsorption clearance pathway using physicochemical properties and structural characteristics	4
Evaluation of MTBH, a novel hesperetin derivative, on the activity of hepatic cytochrome P450 isoform in vitro and in vivo using a cocktail method by HPLC-MS/MS	4
Nrf2 signaling pathway studies in Drosophila melanogaster : parallel roles in human health and insect environmental responses	4
Role of amino acids at positions 34, 296, and 486 of cytochrome P450 2D6 in the stimulatory and inhibitory effects of psychotropic agents on dopamine formation from p-tyramine	4
Preclinical metabolism and disposition of an orally bioavailable macrocyclic FXIa inhibitor	4
Hepatotoxic effect of tramadol and O-desmethyltramadol in HepG2 cells and potential role of PI3K/AKT/mTOR	4
Through a computer monitor darkly: artificial intelligence in absorption, distribution, metabolism and excretion science	4
Academic foreign compound metabolism – ‘ quo vadis ’?	4

Comparison between lab variability andin silicoprediction errors for the unbound fraction of drugs in human plasma	4
Metabolic profiling in liver microsomes and mice of E28, a potent FLT3 inhibitor	4
Rutaecarpine enhances the anti-diabetic activity and hepatic distribution of metformin via up-regulation of Oct1 in diabetic rats	4
Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver	4
Effect of formulation and route of administration on the distribution of 17-hydroxyprogesterone caproate in rats	4
Influence of vitamin D treatment on functional expression of drug disposition pathways in human kidney proximal tubule cells during simulated uremia	4
Thank you to reviewers	4
Influence of UGT2B7 and UGT1A6 polymorphisms on plasma concentration to dose ratio of valproic acid in Chinese epileptic children	4
Species differences in oxidative metabolism of regorafenib	4
Phenolic benzotriazoles: a class comparison of toxicokinetics of ultraviolet-light absorbers in male rats	3
Preparation, characterisation, pharmacokinetics and distribution of esculin microspheres administered via intravitreal injection into rabbit brain	3
Validation of population pharmacokinetic models: a comparison of internal and external validation approaches for hydrochlorothiazide	3
Population pharmacokinetics and dosage optimisation of tacrolimus coadministration with Wuzhi capsule in adult liver transplant patients	3
Metabolite characterisation of the peptide–drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS	3
Relevance of gene polymorphisms of NAT2 and NR1I2 to anti-tuberculosis drug-induced hepatotoxicity	3
Power of integrating PBPK with PBBM (PBPK-BM): a single model predicting food effect, gender impact, drug-drug interactions and bioequivalence in fasting & fed conditions	3
Time matters – in vitro cellular disposition kinetics help rationalizing cellular potency disconnects	3
Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death	3
Quantitative prediction of OATP1B-mediated drug–drug interactions using endogenous biomarker coproporphyrin I	3
Herb–drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa	3
Comparative metabolism of THCA and THCV using UHPLC-Q-Exactive Orbitrap-MS	3
Diurnal hepatic CYP3A11 contributes to chronotoxicity of the pyrrolizidine alkaloid retrorsine in mice	3
Improved preclinical drug metabolism and pharmacokinetics of pibothiadine (HEC121210), a novel hepatitis B virus capsid assembly modulator	3
Pharmacokinetics and metabolism of mirogabalin, a novel α2δ ligand, in rats and monkeys	3
Pharmacokinetics, tissue distribution and excretion of five rhubarb anthraquinones in rats after oral administration of effective fraction of anthraquinones from rheum officinale	3
Elucidating the structure and cytochrome P450-mediated mechanism for novel metabolites of GDC-0575 in rats	3
Response to the comments raised by Fernando Tricta	3
Metabolic activation of zolmitriptan mediated by CYP2D6	3
Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver	3
Comparisons between human and rodent hepatic glutathione S-Transferase activities reveal sex and species differences	3
Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes	3
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity	3
Pharmacokinetics, metabolism and excretion of radiolabeled fostemsavir administered with or without ritonavir in healthy male subjects	3
Predictive marker for exposure-driven haematological toxicity of tegafur-uracil and proposed modified-dosage regimen by pharmacometric approach in rats	3
ADME and DMPK considerations for the discovery and development of antibody drug conjugates (ADCs)	3
Mechanism-based inactivation of cytochromes P450: implications in drug interactions and pharmacotherapy	3
Exploring the pharmacokinetics of second-generation cephalosporin, cefaclor: a systematic review in healthy and diseased populations	2
Pharmacokinetics and pharmacodynamic interaction of bergamottin with atorvastatin in rats	2
A commentary on the use of pharmacoenhancers in the pharmaceutical industry and the implication for DMPK drug discovery strategies	2
Population pharmacokinetics of methotrexate in paediatric patients with acute lymphoblastic leukaemia and malignant lymphoma	2
The effect of ARVs on the MEKKK1 gene promoter, inflammatory cytokine expression and signalling in acute treated Jurkat T cells	2
Effect of genetic polymorphisms on the pharmacokinetics of gefitinib in healthy Chinese volunteers	2
In vitro ADME, mouse pharmacokinetics of LD14b, and bioanalysis of a novel aβ 17β-HSD10 modulator for the treatment of Alzheimer’s disease	2
In vivo evaluation of intestinal human CYP3A inhibition by macrolide antibiotics in CYP3A-humanised mice	2
Absorption, distribution, metabolism and excretion of 14 C-vatiquinone in rats, dogs, and human subjects	2
In vivo evaluation of pharmacokinetic drug–drug interactions between fluorinated pyrimidine anticancer drugs, 5-fluorouracil and capecitabin, and an anticoagulant, warfarin	2
Two curcumin analogs inhibited the function and protein expression of breast cancer resistance protein: in vitro and in vivo studies	2
Effects of benzophenone-3 on the liver and thyroid of adult zebrafish	2
Interactions between cadmium and zinc on gene expression pattern of differentiation markers in MC3T3-E1 cell line	2
Prediction of the liver safety profile of a first-in-class myeloperoxidase inhibitor using quantitative systems toxicology modeling	2
Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets	2
Metabolite profiling and identification of enzymes responsible for the metabolism of hirsutine, a major alkaloid from Uncaria rhynchophylla	2
Drug-drug interaction between danshensu and irbesartan and its potential mechanism	2
Bioanalytical approaches to support the development of antibody-oligonucleotide conjugate (AOC) therapeutic proteins	2
Adenine-related compounds modulate UDP-glucuronosyltransferase (UGT) activity in mouse liver microsomes	2
Effects of the total flavonoid extracts and the monomers of Daphne genkwa on CYP2C8 activity	2
Development and validation of a highly sensitive and selective LC-MS/MS method for the determination of 15-hydroxylubiprostone in human plasma: application to a pharmacokinetic study in healthy Chines	2
In vitro assessment of the inhibitory effect of goreisan extract and its ingredients on the P-glycoprotein drug transporter and cytochrome P-450 metabolic enzymes	2
Pharmacokinetics of levonorgestrel and etonogestrel in rat or minipig following intravenous, subcutaneous, or intradermal administration	2
In silico ADME/tox comes of age: twenty years later	2
Teratogenicity is more likely a function of primary and secondary pharmacology than caused by chemically reactive metabolites: a critical evaluation of 40 years of scientific research	2
Determination of enzymatic kinetics of metabolism of dimethoate and omethoate in rats and humans	2
Evaluation system for cell-permeable CYP3A4 inhibitory activity using 1α,25-dihydroxy-vitamin D3-induced intestinal cell lines	2
Cadmium-induced preeclampsia-like phenotype in the rat is related to decreased progesterone synthesis in the placenta	2
Perspectives on the use of machine learning for ADME prediction at AstraZeneca	2
Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver: the use of physiologically based scaling, a novel solution for potential ov	2
Population pharmacokinetics of mycophenolic acid and dose optimisation in adult Chinese kidney transplant recipients	2
Epifriedelanol enhances adriamycin-induced cytotoxicity towards K562/ADM cells by down regulating of P-gp and MRP2	2
In vitro safety evaluation of (6-methoxy-9-oxo-9 H -xanthen-2-yl)methyl ( E )-3-(2,4-dimethoxyphenyl)acrylate (K-116) –	2
S-Carboxymethyl-l-cysteine: a multiple dosing study using pharmacokinetic modelling	2
Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations	2
Predictive role of polymorphic variants of phase II drug metabolising enzyme in modulating toxicity in North Indian lung cancer patients undergoing chemotherapy	2
In vitro study of the drug–drug interaction potential of cetagliptin and clinical study of pharmacokinetic interaction of cetagliptin and metformin in healthy volunteers	2
Untargeted metabolomics-assisted comparative cytochrome P450-dependent metabolism of fenbendazole in human and dog liver microsomes	2
Effect of drug combination on tacrolimus target dose in renal transplant patients with different CYP3A5 genotypes	2
Effect of capsaicin on breast cancer resistance protein (BCRP/Abcg2) and pharmacokinetics of probe substrates in rats	2
Do differences in cell lines and methods used for calculation of IC50 values influence categorisation of drugs as P-glycoprotein substrates and inhibitors?	2
Prediction of human serum concentration–time profiles of therapeutic monoclonal antibodies using common marmosets ( Callithrix jacchus ): initial assessment with canakin	2
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle	2
Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K	2

Metabolites identification and species comparison of Oroxylin A, an anti-cancer flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS	2
Notable drug-drug interaction between omeprazole and voriconazole in CYP2C19 *1 and *2 (rs4244285, 681G>A) alleles in vitro	2
In vitro modulatory effects of ginsenoside compound K, 20(S)-protopanaxadiol and 20(S)-protopanaxatriol on uridine 5′-diphospho-glucuronosyltransferase activity and expression	2
Evaluation of the non-linearity of NA808 in liver not reflected in plasma using a rat pharmacokinetic study and PBPK modelling	2
Novel omeprazole delayed release orally disintegrating tablets for enhanced patient compliance: a case of model informed formulation development	1
Absorption, distribution, metabolism, and excretion of [14C]TPN729 after oral administration to rats	1
Assessment of cytochrome P450 induction in canine intestinal organoid models	1
UGT1A1 and UGT1A3 activity and inhibition in human liver and intestinal microsomes and a recombinant UGT system under similar assay conditions using selective substrates and inhibitors	1
Effect of tubeimoside I on the activity of cytochrome P450 enzymes in human liver microsomes	1
Metabolic activation of aegeline mediated by CYP2C19	1
Human pharmacokinetics prediction with an in vitro–in vivo correction factor approach and in vitro drug-drug interaction profile of bictegravir, a potent integrase-strand transfer	1
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study	1
Metal-metal interaction and metal toxicity: a comparison between mammalian and D. melanogaster	1
In silico prediction of volume of distribution of drugs in man using conformal prediction performs on par with animal data-based models	1
The metabolite profiling of YR-1702 injection in human plasma, urine and feces by HPLC-Q-TOF-MS/MS	1
Potential influence of interleukin-6 -174G/C gene polymorphism on kidney graft function and tacrolimus dose requirements: five-year follow-up	1
In vitro drug-drug interactions of decitabine and tetrahydrouridine involving drug transporters and drug metabolising enzymes	1
Simultaneous determination of four phytoecdysteroids by LC-MS/MS: application to a comparative pharmacokinetic study in normal and adjuvant arthritis rats after oral administration of C	1
Xenobiotica Special Edition Preface	1
Pharmacokinetics and mass balance of vericiguat in rats and dogs and distribution in rats	1
Three methods to optimise polymyxin B dosing using estimated AUC after first dose: validation with the data generated by Monte Carlo simulation	1
Potential application of mass spectrometry imaging in pharmacokinetic studies	1
Effect of naringenin on the pharmacokinetics of metoprolol succinate in rats	1
The effects of genetic polymorphism on toxicity and pharmacokinetics of methotrexate in Egyptian adult patients with leukaemia or lymphoma	1
2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A2	1
Agrimoniin inhibits the activity of CYP1A2, 2D6, and 3A4 in human liver microsomes	1
Indirubin mediates adverse intestinal reactions in guinea pigs by downregulating the expression of AchE through AhR	1
Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13	1
Spectroscopic observations of β-eudesmol binding to human cytochrome P450 isoforms 3A4 and 1A2, but not to isoforms 2C9, 2C19, and 2D6	1
Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css–MRTpo method and chimeric mice with humanised livers	1
Genetic polymorphism of Arg213His variant in the SULT1A1 gene is associated with reduced susceptibility to lung cancer in North Indian population	1
Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p -nitrophenol	1
Metabolic activation of deferiprone mediated by CYP2A6	1
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human	1
In vitro evaluation of intestinal absorption of tiliroside from Edgeworthia gardneri (Wall.) Meisn.	1
Metabolic conversion of β-pinene to β-ionone in rats	1
Assessment of drug-drug interactions of CC-90001, a potent and selective inhibitor of c-Jun N-terminal kinase	1
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-M	1
Synthesis and evaluation of indomethacin prodrugs with a diester structure that are metabolically activated by human carboxylesterases	1
mRNA expression levels of cytochrome P450 CYP1A2 , CYP3A4 , and CYP3A5 in the epidermis: a focus on individ	1
Metabolism and disposition of zamicastat in rats	1
In vitro study on the effect of leonurine hydrochloride on the enzyme activity of cytochrome P450 enzymes in human liver microsomes	1
Disposition study of the novel dipeptidyl peptidase 4 inhibitor cetagliptin in rats	1
Uptake of antiepileptic drugs in forskolin-induced differentiated BeWo cells: alteration of gabapentin transport	1
Evaluation of molecular markers GSTM1 and GSTT1 and clinical factors in breast cancer: case-control study and literature review	1
In vitro and in vivo evaluation of organic anion-transporting polypeptide 2B1-mediated pharmacokinetic interactions by apple polyphenols	1
Comparative study on ABCB1-dependent efflux of anthracyclines and their metabolites: consequences for cancer resistance	1
Beyond cytotoxic potency: disposition features required to design ADC payload	1
Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes	1
An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds	1
MicroRNA-mediated Krüppel-like factor 4 upregulation induces alternatively activated macrophage-associated marker and chemokine transcription in 4,4’-methylene diphenyl diisocyanate exposed macrophage	1
Effect of berberine on pharmacokinetics and pharmacodynamics of atorvastatin in hyperlipidemia rats	1
A discovery biotransformation strategy: combining in silico tools with high-resolution mass spectrometry and software-assisted data analysis for high-throughput metabolism	1
Renal tubular transporter-mediated interactions between mirogabalin and cimetidine in rats	1
Effects of pharmacogenetics on pharmacokinetics and toxicity of doxorubicin in Egyptian breast cancer patients	1
Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P 1 modulator ponesimod	1
The metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C] cetagliptin in healthy volunteers	1
Disposition and metabolism of ethylene glycol 2-ethylhexyl ether in Sprague Dawley rats, B6C3F1/N mice, and in vitro in rat hepatocytes	1
Approaches to improve the translation of safety, pharmacokinetics and therapeutic index of ADCs	1
Bioavailability, safety and tolerability of intravenous brivaracetam in healthy Japanese participants	1
Thank you to reviewers	1
N-Acetyltransferase 2, glutathione S-transferase gene polymorphisms and susceptibility to hepatocellular carcinoma in an Algerian population	1
Prediction of combination effect of quinidine on the pharmacokinetics of tipepidine using a physiologically based pharmacokinetic model	1
Thank you to reviewers	1
Species and tissue differences in regorafenib glucuronidation	1
Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development	1
N, N -dimethyltryptamine forms oxygenated metabolites via CYP2D6 - an in vitro investigation	1
Physiologically based pharmacokinetic modelling to predict drug–drug interactions for encorafenib. Part I. Model building, validation, and prospective predictions with enzyme inhibitors, inducers, and	1
Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models	1
Experimental and computational models to investigate intestinal drug permeability and metabolism	1
Optimal pH 8.5 to 9 for the hydrolysis of vixotrigine and other basic substrates of carboxylesterase-1 in human liver microsomes	1
Oxidation of 3’-methoxyflavone, 4’-methoxyflavone, and 3’,4’-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13	1
The impact of CYP3A5 , NR1I2 , and POR polymorphisms on tacrolimus dose-adjusted concentration and clinical	1
2-Naphthalenemethanol participates in metabolic activation of 2-methylnaphthalene	1
Safflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics	1
The metabolic activation of and platelet response to vicagrel vary with P-glycoprotein deficiency, rather than P-glycoprotein inhibition, in mice	1