Xenobiotica

Article	Citations
Oxidative metabolism of razuprotafib (AKB-9778), a sulfamic acid phosphatase inhibitor, in human microsomes and recombinant human CYP2C8 enzyme	17
A cysteine trapping assay for risk assessment of reactive acyl CoA metabolites	16
Evaluation of urinary acetaminophen metabolites and its association with the genetic polymorphisms of the metabolising enzymes, and serum acetaminophen concentrations in preterm neonates with patent d	15
Developmental stage and infection status may affect drug distribution in the prostate of rats	15
Utility of preclinical species for uncertainty assessment and correction of prediction of human volume of distribution using the Rodgers-Lukacova model	15
Population pharmacokinetics of sirolimus in Chinese adult liver transplant recipients: a retrospective study	14
In vitro hepatic metabolism of the natural product quebecol	13
Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver	12
One small step in time, one giant leap for DMPK kind – a CRO perspective of the evolving core discipline of drug development	9
Meeting report: oligonucleotide ADME workshop	9
Nrf2 signaling pathway studies in Drosophila melanogaster : parallel roles in human health and insect environmental responses	9
Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2	8
Academic foreign compound metabolism – ‘ quo vadis ’?	8
In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor	7
Role of amino acids at positions 34, 296, and 486 of cytochrome P450 2D6 in the stimulatory and inhibitory effects of psychotropic agents on dopamine formation from p-tyramine	7
Population pharmacokinetics and dosage optimisation of tacrolimus coadministration with Wuzhi capsule in adult liver transplant patients	7
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity	7
Diisononyl phthalate down-regulates the expression of antioxidant genes NFE2L2 , TXN , and TXNRD2 , while d	7
Power of integrating PBPK with PBBM (PBPK-BM): a single model predicting food effect, gender impact, drug-drug interactions and bioequivalence in fasting & fed conditions	7
Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver	7
In silico models to predict tubular secretion or reabsorption clearance pathway using physicochemical properties and structural characteristics	7
Notable drug-drug interaction between omeprazole and voriconazole in CYP2C19 *1 and *2 (rs4244285, 681G>A) alleles in vitro	7
Metabolic activation of zolmitriptan mediated by CYP2D6	7
Evaluation system for cell-permeable CYP3A4 inhibitory activity using 1α,25-dihydroxy-vitamin D3-induced intestinal cell lines	6
An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds	6

Beyond cytotoxic potency: disposition features required to design ADC payload	6
Pharmacokinetics and metabolic disposition of a potent and selective kynurenine monooxygenase inhibitor, CHDI-340246, in laboratory animals	6
Comparisons between human and rodent hepatic glutathione S-Transferase activities reveal sex and species differences	6
In vivo evaluation of pharmacokinetic drug–drug interactions between fluorinated pyrimidine anticancer drugs, 5-fluorouracil and capecitabin, and an anticoagulant, warfarin	6
Adenine-related compounds modulate UDP-glucuronosyltransferase (UGT) activity in mouse liver microsomes	6
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle	6
Safflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics	6
Experimental and computational models to investigate intestinal drug permeability and metabolism	6
Bioavailability, safety and tolerability of intravenous brivaracetam in healthy Japanese participants	6
Effect of genetic polymorphisms on the pharmacokinetics of gefitinib in healthy Chinese volunteers	6
Three methods to optimise polymyxin B dosing using estimated AUC after first dose: validation with the data generated by Monte Carlo simulation	6
Absorption, distribution, metabolism, and excretion of [14C]TPN729 after oral administration to rats	6
Preparation, characterisation, pharmacokinetics and distribution of esculin microspheres administered via intravitreal injection into rabbit brain	6
Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P 1 modulator ponesimod	6
N-Acetyltransferase 2, glutathione S-transferase gene polymorphisms and susceptibility to hepatocellular carcinoma in an Algerian population	6
The effect of ARVs on the MEKKK1 gene promoter, inflammatory cytokine expression and signalling in acute treated Jurkat T cells	6
Effects of the total flavonoid extracts and the monomers of Daphne genkwa on CYP2C8 activity	6
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-M	6
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study	5
2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A2	5
Development of eugenol-fortified fisetin-loaded nano-invasomes gel	5
Elucidation of clearance mechanism of TP0463518, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor: does a species difference in excretion routes exist between humans and animals?	5
Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation	5
2-Naphthalenemethanol participates in metabolic activation of 2-methylnaphthalene	5
The effects of genetic polymorphism on toxicity and pharmacokinetics of methotrexate in Egyptian adult patients with leukaemia or lymphoma	5
Preclinical assessment of the PI3Kα selective inhibitor inavolisib and prediction of its pharmacokinetics and efficacious dose in human	5
DEC1 negatively regulates CYP2B6 expression by binding to the CYP2B6 promoter region ascribed to IL-6-induced downregulation of CYP2B6 expression in HeLa cells	5
Pharmacokinetics and multi-peak phenomenon analysis of novel anti-Parkinson’s drug FLZ after multi-dose in cynomolgus monkeys	5
Renal tubular transporter-mediated interactions between mirogabalin and cimetidine in rats	5
Metabolic activation of deferiprone mediated by CYP2A6	5
Prediction of the Neurotoxic Mechanisms of the Pesticide Phorate Using Network Toxicology, Molecular Docking, and Molecular Dynamics Simulation	5
Interactions of organophosphorus pesticides with ATP-binding cassette (ABC) drug transporters	5
Metabolism of gartanin in liver microsomes and its modulating effects on cytochrome P450s	5
Inorganic mercury pharmacokinetics in man: a hybrid model	4
In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor	4
Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration	4
Human and nonclinical disposition of [14C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection	4
Evobrutinib pathway to its major metabolite M463-2 and insights from a biotransformation and DDI perspective	4
Impact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats	4
Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir	4
Effectiveness of pain care intervention combined with traditional Chinese medicine care in the perioperative care of patients with urinary stones	4
Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans	4
Pharmacokinetics of intranasal drugs, still a missed opportunity?	4
A physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model for the insecticide dimethoate	4
In vitro inhibition and induction of human liver cytochrome P450 enzymes by a novel anti-fibrotic drug fluorofenidone	4
A population pharmacokinetic-pharmacodynamic model of navtemadlin, its glucuronide metabolite (M1) and serum macrophage inhibitory cykokine-1 (MIC-1)	4
Pharmacokinetics, metabolism and off-target effects in the rat of 8-[(1H- benzotriazol-1-yl)amino]octanoic acid, a selective inhibitor of human cytochrome P450 4Z1: β-oxidation as a potential a	4
Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats	4
Bioavailability and dose proportionality of a highly lipophilic phenolic antioxidant	4
The chlorophenoxy herbicide MCPA: a mechanistic basis for the observed differences in toxicological profile in humans and rats versus dogs	4

Application of physiologically based pharmacokinetic models for therapeutic proteins and other novel modalities	4
Sodium dodecylbenzene sulphonate (SDBS) present in detergents: action on the gills, skin, and blood of D. rerio fish	4
Species differences in oxidative metabolism of regorafenib	4
How predictive are isolated perfused liver data of in vivo hepatic clearance? A meta-analysis of isolated perfused rat liver data	4
Pharmacokinetics, tissue distribution, plasma protein binding rate and excretion of sinoacutine following intravenous administration in female and male Sprague-Dawley rats	4
In vivo-in vitrocorrelation of antitumor activity of heat shock protein 90 (HSP90) inhibitors with a pharmacokinetics/pharmacodynamics analysis using NCI-N87 xenograft mice	4
Metabolic profiling in liver microsomes and mice of E28, a potent FLT3 inhibitor	4
Characterisation of seven medications approved for attention-deficit/hyperactivity disorder usingin vitromodels of hepatic metabolism	4
Meeting report of the 3rd European Biotransformation Workshop	4
Effects of tyrosine kinase inhibitors used for the treatment of non-small cell lung carcinoma on cytochrome P450 2J2 activities	4
Preface for special issue: “Emerging strategies, technologies, and approaches for the next generation ADCs”	4
Monomethyl auristatin E (MMAE), a payload for multiple antibody drug conjugates (ADCs), demonstrates differential red blood cell partitioning across human and animal species	4
Hypothesis of using albumin to improve drug efficacy in cancers accompanied by hypoalbuminemia	4
Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury	4
Effect of tubeimoside I on the activity of cytochrome P450 enzymes in human liver microsomes	3
Metabolites identification and species comparison of Oroxylin A, an anti-cancer flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS	3
Perspectives on the use of machine learning for ADME prediction at AstraZeneca	3
Drug-drug interaction between danshensu and irbesartan and its potential mechanism	3
Potential influence of interleukin-6 -174G/C gene polymorphism on kidney graft function and tacrolimus dose requirements: five-year follow-up	3
Determination of enzymatic kinetics of metabolism of dimethoate and omethoate in rats and humans	3
Effect of berberine on pharmacokinetics and pharmacodynamics of atorvastatin in hyperlipidemia rats	3
N, N -dimethyltryptamine forms oxygenated metabolites via CYP2D6 - an in vitro investigation	3
In vitro and in vivo evaluation of organic anion-transporting polypeptide 2B1-mediated pharmacokinetic interactions by apple polyphenols	3
A discovery biotransformation strategy: combining in silico tools with high-resolution mass spectrometry and software-assisted data analysis for high-throughput metabolism	3
Response to the comments raised by Fernando Tricta	3
Population pharmacokinetics of methotrexate in paediatric patients with acute lymphoblastic leukaemia and malignant lymphoma	3
Study of the urinary metabolites of 17ɑ-methyl-19-nortestosterone in human using gas chromatography – mass spectrometry. Preliminary results	3
Predictive marker for exposure-driven haematological toxicity of tegafur-uracil and proposed modified-dosage regimen by pharmacometric approach in rats	3
Approaches to improve the translation of safety, pharmacokinetics and therapeutic index of ADCs	3
Preclinical pharmacokinetics, CYP phenotyping, and tissue distribution study of novel anti-breast cancer candidate S-011-1559	3
Benzophenone-3 (oxybenzone) in zebrafish: histopathological and oxidative stress analysis	3
Potential application of mass spectrometry imaging in pharmacokinetic studies	3
Thank you to reviewers	3
In vitro study of the drug–drug interaction potential of cetagliptin and clinical study of pharmacokinetic interaction of cetagliptin and metformin in healthy volunteers	3
The impact of CYP3A5 , NR1I2 , and POR polymorphisms on tacrolimus dose-adjusted concentration and clinical	3
In vitro modulatory effects of ginsenoside compound K, 20(S)-protopanaxadiol and 20(S)-protopanaxatriol on uridine 5′-diphospho-glucuronosyltransferase activity and expression	3
Pharmacokinetics, metabolism and excretion of radiolabeled fostemsavir administered with or without ritonavir in healthy male subjects	3
Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K	3
Genetic polymorphism of Arg213His variant in the SULT1A1 gene is associated with reduced susceptibility to lung cancer in North Indian population	3
The metabolism of the dual orexin receptor antagonist daridorexant	3
Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models	3
Assessment of drug-drug interactions of CC-90001, a potent and selective inhibitor of c-Jun N-terminal kinase	3
Metal-metal interaction and metal toxicity: a comparison between mammalian and D. melanogaster	3
Bottom-up physiologically based pharmacokinetic modelling for predicting the human pharmacokinetic profiles of the ester prodrug MGS0274 and its active metabolite MGS0008, a metabotropic glutamate 2/3	2
Meeting report: 3rd workshop of the peptide ADME discussion group	2
Meeting report: DMDG peptide and oligonucleotide ADME workshop 2022	2
Preclinical metabolism and disposition of an orally bioavailable macrocyclic FXIa inhibitor	2
UGT1A1 and UGT1A3 activity and inhibition in human liver and intestinal microsomes and a recombinant UGT system under similar assay conditions using selective substrates and inhibitors	2
Physiologically based pharmacokinetic modelling to predict drug–drug interactions for encorafenib. Part I. Model building, validation, and prospective predictions with enzyme inhibitors, inducers, and	2
S-Carboxymethyl-l-cysteine: a multiple dosing study using pharmacokinetic modelling	2
In vitro and in vivo metabolic profiling of PD105, a PI3Kδ inhibitor, using UHPLC-Q-Exactive plus-MS	2
Synthesis and evaluation of indomethacin prodrugs with a diester structure that are metabolically activated by human carboxylesterases	2
Meeting report of the second European biotransformation workshop	2
Evaluation of the effect of Bovis Calculus Artifactus on eight rat liver cytochrome P450 isozymes using LC-MS/MS and cocktail approach	2
Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver	2
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs	2
Quantitative prediction of OATP1B-mediated drug–drug interactions using endogenous biomarker coproporphyrin I	2
Biochemical responses of the mussel Perna perna after exposure to environmental concentrations of the UV filter Benzophenone-3	2
Predictive role of polymorphic variants of phase II drug metabolising enzyme in modulating toxicity in North Indian lung cancer patients undergoing chemotherapy	2
Investigation of pharmacokinetic properties of a PEGylated bilirubin nanoparticle in male Sprague-Dawley rats using liquid chromatography-quadrupole time-of-flight mass spectrometry	2
Pharmacokinetics of chelerythrine and its metabolite after oral and intramuscular administrations in pigs	2
Use of stable isotope labeled (SIL) antibodies in cassette dosing to improve pharmacokinetics screening efficiency of ADCs with novel cytotoxic payloads	2
Comparative study on ABCB1-dependent efflux of anthracyclines and their metabolites: consequences for cancer resistance	2
Comprehensive characterization and optimization of Caco-2 cells enabled the development of a miniaturized 96-well permeability assay	2
Metabolism and disposition of zamicastat in rats	2
Investigation on the in vitro metabolism of bicyclol using liver microsomes, hepatocytes and human recombinant cytochrome P450 enzymes	2
Epifriedelanol enhances adriamycin-induced cytotoxicity towards K562/ADM cells by down regulating of P-gp and MRP2	2
Emerging conjugation strategies and protein engineering technologies aim to improve ADCs in the fight against cancer	2
Pharmacokinetics, distribution and efficacy of triptolide PLGA microspheres after intra-articular injection in a rat rheumatoid arthritis model	2
Evaluation of the non-linearity of NA808 in liver not reflected in plasma using a rat pharmacokinetic study and PBPK modelling	2
Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase	2
Metabolite characterisation of the peptide–drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS	2
The in vivo disposition of subcutaneous injected 14C-razuprotafib (14C-AKB-9778), a sulphamic acid phosphatase inhibitor, in nonclinical species and human	2
Effects of paeoniflorin on the activities and mRNA expression of rat CYP1A2, CYP2C11 and CYP3A1 enzymes in vivo	2
Feature-based molecular networking updates the in vitro metabolic characterization of fenbendazole across species	2
Role of hesperidin and fresh orange juice in altering the bioavailability of beta-blocker, metoprolol tartrate. An in vivo model	2
A translational strategy employing physiologically based modelling to predict the pharmacological active dose of RO7119929, an oral prodrug of a targeted cancer immunotherapy TLR7 agonist	2
Prediction of the liver safety profile of a first-in-class myeloperoxidase inhibitor using quantitative systems toxicology modeling	2
Effect of naringenin on the pharmacokinetics of metoprolol succinate in rats	2
Dolutegravir metabolism: impact of genetic variations on uridine diphosphate glucuronosyltransferase subfamilies	2

In vitro study on the effect of leonurine hydrochloride on the enzyme activity of cytochrome P450 enzymes in human liver microsomes	2
Mechanism-based inactivation of cytochrome P450 3A by evodol	2
Metabolic conversion of β-pinene to β-ionone in rats	2
Meeting report: DMPK optimisation strategies and quantitative translational PKPD frameworks to predict human PK and efficacious dose of targeted protein degraders	2
Study on the transport and internalisation mechanism of dietary supplement nattokinase in the small intestine using animal and Caco-2 cell monolayer models	2
Mechanism-based inactivation of cytochromes P450: implications in drug interactions and pharmacotherapy	2
Qualitative and quantitative status of cytochrome P450s after the administration of a liposomal platelet substitute in rat liver	2
Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death	2
Prediction of pharmacokinetics of an anaplastic lymphoma kinase inhibitor in rat and monkey: application of physiologically based pharmacokinetic model as an alternative tool to minimise animal studie	2
Prospective prediction of plasma pharmacokinetics of a novel immune-modulating agent in cancer patients after intra-tumoral administration: translation from non-clinical species to humans	2
Metabolic activation of aegeline mediated by CYP2C19	1
Changes in the expression of drug-metabolising enzymes and drug transporters in mice with collagen antibody-induced arthritis	1
Two curcumin analogs inhibited the function and protein expression of breast cancer resistance protein: in vitro and in vivo studies	1
Association between pharmacokinetics of lenvatinib in healthy subjects and genetic polymorphisms of ABCB1 3435C>T and ABCB1 2677G>T/A	1
Pharmacokinetics, tissue distribution and excretion of five rhubarb anthraquinones in rats after oral administration of effective fraction of anthraquinones from rheum officinale	1
Toxicokinetic and mass balance of morpholine in rats	1
Effects of pharmacogenetics on pharmacokinetics and toxicity of doxorubicin in Egyptian breast cancer patients	1
Comparing the pharmacokinetics and organ/tissue distribution of anti-methicillin-resistant Staphylococcus aureus agents using a rat model of sepsis	1
Assessment of cytochrome P450 induction in canine intestinal organoid models	1
Teratogenicity is more likely a function of primary and secondary pharmacology than caused by chemically reactive metabolites: a critical evaluation of 40 years of scientific research	1
Justification of widened dissolution specifications of an extended-release product using physiologically based biopharmaceutics modeling	1
Do differences in cell lines and methods used for calculation of IC50 values influence categorisation of drugs as P-glycoprotein substrates and inhibitors?	1
Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations	1
The 50th anniversary of the DMDG	1
Development and validation of a highly sensitive and selective LC-MS/MS method for the determination of 15-hydroxylubiprostone in human plasma: application to a pharmacokinetic study in healthy Chines	1
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human	1
A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin-cleavable ADC linkers	1
Validation of population pharmacokinetic models: a comparison of internal and external validation approaches for hydrochlorothiazide	1
UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers	1
Impact of CYP2C19 genotype on voriconazole exposure and effect of voriconazole on the activity of CYP3A in patients with haematological malignancies	1
ADME properties of CHF6366, a novel bi-functional M3 muscarinic receptor antagonist and ß2 adrenoceptor agonist (MABA) radiolabelled at both functional moieties	1
Population pharmacokinetics of mycophenolic acid and dose optimisation in adult Chinese kidney transplant recipients	1
A general perspective for the conduct of radiolabelled distribution, metabolism, and excretion studies for antibody-drug conjugates	1
Inhibition of YAP can down-regulate NLRP3 inflammasome and improve anti-tuberculosis drug-induced liver injury	1
Through a computer monitor darkly: artificial intelligence in absorption, distribution, metabolism and excretion science	1
Effect of drug combination on tacrolimus target dose in renal transplant patients with different CYP3A5 genotypes	1
Sex differences in the pharmacokinetics and tissue residues of Macleaya cordata extracts in rats	1
Optimising pirfenidone dosage regimens in idiopathic pulmonary fibrosis: towards a guide for personalised treatment	1
Indirubin mediates adverse intestinal reactions in guinea pigs by downregulating the expression of AchE through AhR	1
Metabolite profiling and identification of enzymes responsible for the metabolism of hirsutine, a major alkaloid from Uncaria rhynchophylla	1
Rehmannioside A inhibits the activity of CYP3A4, 2C9 and 2D6 in vitro	1
Uptake of antiepileptic drugs in forskolin-induced differentiated BeWo cells: alteration of gabapentin transport	1
Pharmacokinetics and tissue distribution of intranasal administration of rapamycin in rats	1
Association of ABCG2 polymorphisms with susceptibility to anti-tuberculosis drug-induced hepatotoxicity in the Chinese population	1
Evaluation of MTBH, a novel hesperetin derivative, on the activity of hepatic cytochrome P450 isoform in vitro and in vivo using a cocktail method by HPLC-MS/MS	1
Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p -nitrophenol	1
Evaluation of molecular markers GSTM1 and GSTT1 and clinical factors in breast cancer: case-control study and literature review	1
Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver: the use of physiologically based scaling, a novel solution for potential ov	1
Danazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats	1
In vitro safety evaluation of (6-methoxy-9-oxo-9 H -xanthen-2-yl)methyl ( E )-3-(2,4-dimethoxyphenyl)acrylate (K-116) –	1
In vitro and in vivo studies on the metabolism and pharmacokinetics of the selective gut microbial β-glucuronidase targeting compound Inh 1	1
The impact of ibuprofen on valproic acid plasma concentration in pediatric patients	1
Clinical pharmacokinetics of cefixime: a systematic review	1
Absorption, metabolism, and excretion of [14C]-sebetralstat (KVD900) following a single oral dose in healthy male participants	1
Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets	1
Correction	1
Preclinical metabolism and disposition of [ 14 C]GFH009, a novel selective CDK9 inhibitor	1
Rutaecarpine enhances the anti-diabetic activity and hepatic distribution of metformin via up-regulation of Oct1 in diabetic rats	1
Use of selective substrates and inhibitors to rapidly characterise batches of cryopreserved primary human hepatocytes for assessment of active uptake liability in drug discovery and development	1
Anastrozole and related glucuronic acid conjugate are electrophilic species	1
Relevance of gene polymorphisms of NAT2 and NR1I2 to anti-tuberculosis drug-induced hepatotoxicity	1
Association of polymorphism of CYP3A4, ABCB1, ABCC2, ABCG2, NFKB1, POR, and PXR with the concentration of cyclosporin A in allogeneic haematopoietic stem cell transplantation recipients	1
The metabolic activation of and platelet response to vicagrel vary with P-glycoprotein deficiency, rather than P-glycoprotein inhibition, in mice	1
Exploring the pharmacokinetics of second-generation cephalosporin, cefaclor: a systematic review in healthy and diseased populations	1
Combination of losartan and puerarin induced pharmacokinetic interaction in hypertension rats enhances the antihypertensive effect of losartan	1
MicroRNA-mediated Krüppel-like factor 4 upregulation induces alternatively activated macrophage-associated marker and chemokine transcription in 4,4’-methylene diphenyl diisocyanate exposed macrophage	1
The pharmacokinetics of dabigatran in a rat model of hyperlipidaemia induced by poloxamer 407	1
Oxidation of 3’-methoxyflavone, 4’-methoxyflavone, and 3’,4’-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13	1
Herb–drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa	1
Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development	1
Prediction of combination effect of quinidine on the pharmacokinetics of tipepidine using a physiologically based pharmacokinetic model	1
Comparative metabolism of THCA and THCV using UHPLC-Q-Exactive Orbitrap-MS	1
Species-dependent hepatic and intestinal metabolism of selective oestrogen receptor degrader LSZ102 by sulphation and glucuronidation	1
Hepatotoxic effect of tramadol and O-desmethyltramadol in HepG2 cells and potential role of PI3K/AKT/mTOR	1
CYP-catalysed cycling of clozapine and clozapine- N -oxide promotes the generation of reactive oxygen species in vitro	1
The metabolism of the orexin-1 selective receptor antagonist nivasorexant	1
Meeting report of the 5th European Biotransformation Workshop	1
The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro	1
Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies	1
Interactions between cadmium and zinc on gene expression pattern of differentiation markers in MC3T3-E1 cell line	1
Pharmacokinetics of the novel 5-HT 4 receptor agonist, DA-6886, in dogs	1