Xenobiotica

Article	Citations
Expression of cytochrome P450 isozyme transcripts and activities in human livers	31
Colchicine for the treatment of COVID-19 patients: efficacy, safety, and model informed dosage regimens	25
Amalgamation of in-silico, in-vitro and in-vivo approach to establish glabridin as a potential CYP2E1 inhibitor	16
Pharmacokinetics, tissue distribution and excretion of five rhubarb anthraquinones in rats after oral administration of effective fraction of anthraquinones from rheum officinale	15
Comparison between lab variability andin silicoprediction errors for the unbound fraction of drugs in human plasma	15
In silico prediction of volume of distribution of drugs in man using conformal prediction performs on par with animal data-based models	15
FXR activation prevents liver injury induced byTripterygium wilfordiipreparations	13
Oral bioavailability and pharmacokinetics of esculetin following intravenous and oral administration in rats	13
Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer–Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active m	12
Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes	12
Metal-metal interaction and metal toxicity: a comparison between mammalian and D. melanogaster	11
Pharmacokinetics and metabolism of brexpiprazole, a novel serotonin-dopamine activity modulator and its main metabolite in rat, monkey and human	11
Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes	11
In vitro evaluations for pharmacokinetic drug-drug interactions of a novel serotonin-dopamine activity modulator, brexpiprazole	9
Pharmacokinetic changes of clozapine and norclozapine in a rat model of non-alcoholic fatty liver disease induced by orotic acid	9
Rapid determination of the pharmacokinetics and metabolic fate of gefitinib in the mouse using a combination of UPLC/MS/MS, UPLC/QToF/MS, and ion mobility (IM)-enabled UPLC/QToF/MS	9
Effects of paeoniflorin on the activities and mRNA expression of rat CYP1A2, CYP2C11 and CYP3A1 enzymes in vivo	9
Employing in vitro metabolism to guide design of F-labelled PET probes of novel α-synuclein binding bifunctional compounds	8
In vitro study of the drug–drug interaction potential of cetagliptin and clinical study of pharmacokinetic interaction of cetagliptin and metformin in healthy volunteers	8
Evaluation of the drug–drug interaction potential for trazpiroben (TAK-906), a D2/D3 receptor antagonist for gastroparesis, towards cytochrome P450s and transporters	8
Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models	8
Curcumin-loaded hydroxypropyl-β-cyclodextrin inclusion complex with enhanced dissolution and oral bioavailability for epilepsy treatment	8
Preclinical pharmacokinetics, CYP phenotyping, and tissue distribution study of novel anti-breast cancer candidate S-011-1559	8
A comprehensive profiling and identification of liquiritin metabolites in rats using ultra-high-performance liquid chromatography coupled with linear ion trap–orbitrap mass spectrometer	8
Preclinical in vitro and in vivo pharmacokinetic properties of danicamtiv, a new targeted myosin activator for the treatment of dilated ca	7

Roles of cytochrome P450 2A6 in the oxidation of flavone, 4′-hydroxyflavone, and 4′-, 3′-, and 2′-methoxyflavones by human liver microsomes	7
The permeability characteristics and interaction of main components from Si-Ni-San in a MDCK epithelial cell monolayer model	7
Association of polymorphism of CYP3A4, ABCB1, ABCC2, ABCG2, NFKB1, POR, and PXR with the concentration of cyclosporin A in allogeneic haematopoietic stem cell transplantation recipients	7
Hepatotoxic effect of tramadol and O-desmethyltramadol in HepG2 cells and potential role of PI3K/AKT/mTOR	7
Pharmacokinetics, metabolism, and excretion of licogliflozin, a dual inhibitor of SGLT1/2, in rats, dogs, and humans	6
Comparative HPLC-MS/MS-based pharmacokinetic studies of multiple diterpenoid alkaloids following the administration of Zhenwu Tang and Radix Aconiti Lateralis Praeparata extracts to rats	6
Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13	6
Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death	6
Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans	6
Preclinical pharmacokinetics and metabolism of MAK683, a clinical stage selective oral embryonic ectoderm development (EED) inhibitor for cancer treatment	6
Metabolic activation of deferiprone mediated by CYP2A6	6
Absorption, distribution, metabolism, and excretion of three [14C]PBDE congeners in laying hens and transfer to eggs.	6
Metabolism, excretion, and pharmacokinetics of [14C]mirogabalin, a novel α2δ ligand, in healthy volunteers following oral administration	6
In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor	6
In silico predictions of the human pharmacokinetics/toxicokinetics of 65 chemicals from various classes using conformal prediction methodology	6
Comprehensive identification, fragmentation pattern, and metabolic pathways of gefitinib metabolites via UHPLC-Q-TOF-MS/MS:in vivostudy of rat plasma, urine, bile, and faeces	6
Metabolic activation of zolmitriptan mediated by CYP2D6	6
A comprehensive analysis of six forms of cytochrome P450 2C (CYP2C) in pigs	6
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity	5
Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes	5
Assessment of the in vitro cytochrome P450 (CYP) inhibition potential of nafithromycin, a next generation lactone ketolide antibiotic	5
Impact of CYP2C19 genotype on voriconazole exposure and effect of voriconazole on the activity of CYP3A in patients with haematological malignancies	5
A discovery biotransformation strategy: combining in silico tools with high-resolution mass spectrometry and software-assisted data analysis for high-throughput metabolism	5
Effect of naringenin on the pharmacokinetics of metoprolol succinate in rats	5
Inhibitory effect of ketoconazole, quinidine and 1-aminobenzotriazole on pharmacokinetics of l-tetrahydropalmatine and its metabolite in rats	5
Power of integrating PBPK with PBBM (PBPK-BM): a single model predicting food effect, gender impact, drug-drug interactions and bioequivalence in fasting & fed conditions	5
Effect of CYP2C9 genetic polymorphism and breviscapine on losartan pharmacokinetics in healthy subjects	5
Absorption, metabolism, and excretion of [14C]YY-20394, a highly selective PI3K-Delta inhibitor in humans	5
Meeting report: 3rd workshop of the peptide ADME discussion group	5
Assessment of drug-drug interactions of CC-90001, a potent and selective inhibitor of c-Jun N-terminal kinase	5
Evaluation of molecular markers GSTM1 and GSTT1 and clinical factors in breast cancer: case-control study and literature review	5
Population pharmacokinetics of methotrexate in paediatric patients with acute lymphoblastic leukaemia and malignant lymphoma	5
Influence of UGT2B7 and UGT1A6 polymorphisms on plasma concentration to dose ratio of valproic acid in Chinese epileptic children	5
Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase	5
Polymorphisms in xenobiotic metabolism-related genes in patients with hepatocellular carcinoma: a case–control study	5
MicroRNA-mediated calcineurin signaling activation induces CCL2, CCL3, CCL5, IL8, and chemotactic activities in 4,4′-methylene diphenyl diisocyanate exposed macrophages	5
Comprehensive characterization and optimization of Caco-2 cells enabled the development of a miniaturized 96-well permeability assay	5
In silico ADME/tox comes of age: twenty years later	5
Metabolites identification and species comparison of Oroxylin A, an anti-cancer flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS	4
Tolerability, safety, pharmacokinetics and pharmacodynamics of SHR0534, a potent G protein-coupled receptor 40 (GPR40) agonist, at single- and multiple-ascending oral doses in healthy Chinese subjects	4
Pharmacokinetics, metabolism and excretion of radiolabeled fostemsavir administered with or without ritonavir in healthy male subjects	4
Population pharmacokinetics and dosage optimisation of tacrolimus coadministration with Wuzhi capsule in adult liver transplant patients	4
A cysteine trapping assay for risk assessment of reactive acyl CoA metabolites	4
Pharmacokinetics, tissue distribution, plasma protein binding rate and excretion of sinoacutine following intravenous administration in female and male Sprague-Dawley rats	4
Identification of the metabolites produced following Iris tectorum Maxim oral administration and a network pharmacology-based analysis of their potential pharmacological properties	4
Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir	4
Optimal pH 8.5 to 9 for the hydrolysis of vixotrigine and other basic substrates of carboxylesterase-1 in human liver microsomes	4
Physiologically based pharmacokinetic modelling to predict drug–drug interactions for encorafenib. Part I. Model building, validation, and prospective predictions with enzyme inhibitors, inducers, and	4
Absorption, distribution, metabolism, and excretion of [14C]TPN729 after oral administration to rats	4
Differential in vitro interactions of the Janus kinase inhibitor ruxolitinib with human SLC drug transporters	4

ADME and DMPK considerations for the discovery and development of antibody drug conjugates (ADCs)	4
Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver	4
Evaluation of urinary acetaminophen metabolites and its association with the genetic polymorphisms of the metabolising enzymes, and serum acetaminophen concentrations in preterm neonates with patent d	4
The common indoor air pollutant α-pinene is metabolised to a genotoxic metabolite α-pinene oxide	4
Physiologically based pharmacokinetic modeling (PBPK) to predict drug-drug interactions for encorafenib. Part II. Prospective predictions in hepatic and renal impaired populations with clinical inhibi	4
Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies	4
The metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C] cetagliptin in healthy volunteers	4
UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers	4
N-Acetyltransferase 2, glutathione S-transferase gene polymorphisms and susceptibility to hepatocellular carcinoma in an Algerian population	4
Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common m	4
In vitro modulatory effects of ginsenoside compound K, 20(S)-protopanaxadiol and 20(S)-protopanaxatriol on uridine 5′-diphospho-glucuronosyltransferase activity and expression	4
Metabolism of the antipsychotic drug olanzapine by CYP3A43	4
Quantitative prediction of OATP1B-mediated drug–drug interactions using endogenous biomarker coproporphyrin I	4
Pomegranate peel polyphenols interaction with intestinal flora and its metabolic transformation	4
Sex differences in the pharmacokinetics and tissue residues of Macleaya cordata extracts in rats	4
Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling	4
Drug–drug interaction comparison between tacrolimus and phenobarbital in different formulations for paediatrics and adults	4
4-O-galloylalbiflorin inhibits the activity of CYP3A, 2C9, and 2D in human liver microsomes	4
The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity	4
Pharmacokinetics of chelerythrine and its metabolite after oral and intramuscular administrations in pigs	4
In vitro drug-drug interactions of decitabine and tetrahydrouridine involving drug transporters and drug metabolising enzymes	4
Epifriedelanol enhances adriamycin-induced cytotoxicity towards K562/ADM cells by down regulating of P-gp and MRP2	3
Genetic polymorphism of Arg213His variant in the SULT1A1 gene is associated with reduced susceptibility to lung cancer in North Indian population	3
Time matters – in vitro cellular disposition kinetics help rationalizing cellular potency disconnects	3
Diurnal hepatic CYP3A11 contributes to chronotoxicity of the pyrrolizidine alkaloid retrorsine in mice	3
Verification of a cocktail approach for quantitative drug–drug interaction assessment: a comparative analysis between the results of a single drug and a cocktail drug	3
Activation of Nrf2 decreases bile acid concentrations in livers of female mice	3
Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation	3
Tissue and interspecies comparison of catechol-O-methyltransferase mediated catalysis of 6-O-methylation of esculetin to scopoletin and its inhibition by entacapone and tolcapone	3
Drug clearance by aldehyde oxidase: can we avoid clinical failure?	3
Mass balance study of [14C]SHR0302, a selective and potent JAK1 inhibitor in humans	3
2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A2	3
In vitro evaluation of intestinal absorption of tiliroside from Edgeworthia gardneri (Wall.) Meisn.	3
Uptake of antiepileptic drugs in forskolin-induced differentiated BeWo cells: alteration of gabapentin transport	3
In vitrostudy on the effect of ophiopogonin D on the activity of cytochrome P450 enzymes	3
In vitro assessment of the inhibitory effect of goreisan extract and its ingredients on the P-glycoprotein drug transporter and cytochrome P-450 metabolic enzymes	3
Herb–drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa	3
Species differences in oxidative metabolism of regorafenib	3
In vitro inhibition and induction of human liver cytochrome P450 enzymes by a novel anti-fibrotic drug fluorofenidone	3
Pharmacokinetics, distribution and efficacy of triptolide PLGA microspheres after intra-articular injection in a rat rheumatoid arthritis model	3
A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction	3
Single dose pharmacokinetics of topical iodiconazole creams in healthy Chinese volunteers	3
Human mass balance, metabolism, and cytochrome P450 phenotyping of lusutrombopag	3
Metabolic activation of aegeline mediated by CYP2C19	3
Pharmacokinetics and mass balance of vericiguat in rats and dogs and distribution in rats	3
Human pharmacokinetics prediction with an in vitro–in vivo correction factor approach and in vitro drug-drug interaction profile of bictegravir, a potent integrase-strand transfer	3
Species and tissue differences in regorafenib glucuronidation	3
Comparative metabolism of THCA and THCV using UHPLC-Q-Exactive Orbitrap-MS	3
Role of amino acids at positions 34, 296, and 486 of cytochrome P450 2D6 in the stimulatory and inhibitory effects of psychotropic agents on dopamine formation from p-tyramine	3
Relevance of gene polymorphisms of NAT2 and NR1I2 to anti-tuberculosis drug-induced hepatotoxicity	3
Absorption, metabolism, and excretion of [14C]-sebetralstat (KVD900) following a single oral dose in healthy male participants	3
Novel application of PBBM to justify impact of faster dissolution on safety and pharmacokinetics – a case study and utility in regulatory justifications	3
Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration	3
Transcription profiling of cadmium-exposed livers reveals alteration of lipid metabolism and predisposition to hepatic steatosis	3
mmu-miR-199a-5p regulates CYP2B10 through repression of E4BP4 in mouse AML-12 hepatocytes	3
In vitro metabolism of HMTD and blood stability and toxicity of peroxide explosives (TATP and HMTD) in canines and humans	3
Assessment of cytochrome P450 induction in canine intestinal organoid models	3
Potential application of mass spectrometry imaging in pharmacokinetic studies	3
Preclinical metabolism and disposition of an orally bioavailable macrocyclic FXIa inhibitor	2
Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models	2
Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver	2
Investigation on the in vitro metabolism of bicyclol using liver microsomes, hepatocytes and human recombinant cytochrome P450 enzymes	2
In silico models to predict tubular secretion or reabsorption clearance pathway using physicochemical properties and structural characteristics	2
The in vitro metabolism and in vivo pharmacokinetics of the bacterial β-glucuronidase inhibitor UNC10201652	2
Meeting report: oligonucleotide ADME workshop	2
A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin-cleavable ADC linkers	2
Non-clinical studies indicating lack of interactions between iron/calcium ions and linzagolix, an orally available GnRH antagonist	2
Meeting report of the second European biotransformation workshop	2
Lung cell toxicity of co-exposure to airborne particulate matter and extremely low-frequency magnetic field	2
Oxidation of 3’-methoxyflavone, 4’-methoxyflavone, and 3’,4’-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13	2
Absorption, distribution, metabolism and excretion of 14 C-vatiquinone in rats, dogs, and human subjects	2
Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K	2
Phenolic benzotriazoles: a class comparison of toxicokinetics of ultraviolet-light absorbers in male rats	2
The history and future of population pharmacokinetic analysis in drug development	2
Preliminary in vitro approach to evaluate the drug-drug interaction potential of EST73502, a dual µ-opioid receptor partial agonist and σ1 receptor antagonist	2
In vitro metabolism assessment of thiacloprid in rainbow trout and rat by LC-UV and high resolution-mass spectrometry	2
Effect of drug combination on tacrolimus target dose in renal transplant patients with different CYP3A5 genotypes	2
Drug–drug interaction potential and clinical pharmacokinetics of enerisant, a novel potent and selective histamine H3 receptor antagonist	2
Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury	2
Meeting report of the 4th European biotransformation workshop	2

Anastrozole and related glucuronic acid conjugate are electrophilic species	2
4,4’-Methylene diphenyl diisocyanate exposure induces expression of alternatively activated macrophage-associated markers and chemokines partially through Krüppel-like factor 4 mediated signaling in m	2
Population pharmacokinetics of sirolimus in Chinese adult liver transplant recipients: a retrospective study	2
Monomethyl auristatin E (MMAE), a payload for multiple antibody drug conjugates (ADCs), demonstrates differential red blood cell partitioning across human and animal species	2
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs	2
Oxidative metabolism of razuprotafib (AKB-9778), a sulfamic acid phosphatase inhibitor, in human microsomes and recombinant human CYP2C8 enzyme	2
Experimental and computational models to investigate intestinal drug permeability and metabolism	2
UGT1A1 and UGT1A3 activity and inhibition in human liver and intestinal microsomes and a recombinant UGT system under similar assay conditions using selective substrates and inhibitors	2
In vitro study on the effect of leonurine hydrochloride on the enzyme activity of cytochrome P450 enzymes in human liver microsomes	2
Evaluation system for cell-permeable CYP3A4 inhibitory activity using 1α,25-dihydroxy-vitamin D3-induced intestinal cell lines	2
Pharmacokinetics and metabolism of mirogabalin, a novel α2δ ligand, in rats and monkeys	2
Application of physiologically based pharmacokinetic models for therapeutic proteins and other novel modalities	2
A commentary on the use of pharmacoenhancers in the pharmaceutical industry and the implication for DMPK drug discovery strategies	2
Pharmacokinetics, metabolism and off-target effects in the rat of 8-[(1H- benzotriazol-1-yl)amino]octanoic acid, a selective inhibitor of human cytochrome P450 4Z1: β-oxidation as a potential a	2
Metabolism, pharmacokinetics and excretion of [14C]dimethyl fumarate in healthy volunteers: an example of xenobiotic biotransformation following endogenous metabolic pathways	2
Human and nonclinical disposition of [14C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection	2
Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2	2
Sodium dodecylbenzene sulphonate (SDBS) present in detergents: action on the gills, skin, and blood of D. rerio fish	2
Changes in the expression of drug-metabolising enzymes and drug transporters in mice with collagen antibody-induced arthritis	2
Role of hesperidin and fresh orange juice in altering the bioavailability of beta-blocker, metoprolol tartrate. An in vivo model	2
Curcumin and quercetin modify warfarin-induced regulation of porcine CYP1A2 and CYP3A expression and activity in vitro	2
An integrated analytical strategy to decipher the metabolic profile of alkaloids in Compound Kushen injection based on UHPLC-ESI-QTOF/MSE	2
Species-dependent hepatic and intestinal metabolism of selective oestrogen receptor degrader LSZ102 by sulphation and glucuronidation	2
2-Naphthalenemethanol participates in metabolic activation of 2-methylnaphthalene	2
Spectroscopic observations of β-eudesmol binding to human cytochrome P450 isoforms 3A4 and 1A2, but not to isoforms 2C9, 2C19, and 2D6	2
In vivo evaluation of intestinal human CYP3A inhibition by macrolide antibiotics in CYP3A-humanised mice	2
Elucidating the structure and cytochrome P450-mediated mechanism for novel metabolites of GDC-0575 in rats	2
Assessment of pharmacokinetic mycophenolic acid clearance models using Monte Carlo numerical analysis	2
The in vivo disposition of subcutaneous injected 14C-razuprotafib (14C-AKB-9778), a sulphamic acid phosphatase inhibitor, in nonclinical species and human	2
Bottom-up physiologically based pharmacokinetic modelling for predicting the human pharmacokinetic profiles of the ester prodrug MGS0274 and its active metabolite MGS0008, a metabotropic glutamate 2/3	1
Predictive marker for exposure-driven haematological toxicity of tegafur-uracil and proposed modified-dosage regimen by pharmacometric approach in rats	1
The 50th anniversary of the DMDG	1
Validation of population pharmacokinetic models: a comparison of internal and external validation approaches for hydrochlorothiazide	1
Population pharmacokinetics of mycophenolic acid and dose optimisation in adult Chinese kidney transplant recipients	1
Dose-dependent pharmacokinetics of midazolam in rats: influence of hepatic first-pass metabolism	1
Predicting routes of phase I and II metabolism based on quantum mechanics and machine learning	1
Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development	1
Pharmacokinetics, tissue distribution and excretion of a novel long-acting human insulin analogue – recombinant insulin LysArg in rats	1
Novel omeprazole delayed release orally disintegrating tablets for enhanced patient compliance: a case of model informed formulation development	1
Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of [ 14 C]aficamten following single oral dose administration to rats	1
Bioavailability, safety and tolerability of intravenous brivaracetam in healthy Japanese participants	1
Cadmium-induced preeclampsia-like phenotype in the rat is related to decreased progesterone synthesis in the placenta	1
Absorption, distribution, metabolism and excretion of 14C-Emvododstat following a single oral dose in rats and dogs	1
Pharmacokinetics of levonorgestrel and etonogestrel in rat or minipig following intravenous, subcutaneous, or intradermal administration	1
Hypothesis of using albumin to improve drug efficacy in cancers accompanied by hypoalbuminemia	1
Metabolic conversion of β-pinene to β-ionone in rats	1
Effects of breviscapine and C3435T MDR1 gene polymorphism on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy volunteers	1
Interactions of organophosphorus pesticides with ATP-binding cassette (ABC) drug transporters	1
Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver: the use of physiologically based scaling, a novel solution for potential ov	1
Commentary concerning the publication by Zheng X et al.: Metabolic activation of deferiprone mediated by CYP2A6 (Xenobiotica, published online 18 May 2021)	1
S-Carboxymethyl-l-cysteine: a multiple dosing study using pharmacokinetic modelling	1
DEC1 negatively regulates CYP2B6 expression by binding to the CYP2B6 promoter region ascribed to IL-6-induced downregulation of CYP2B6 expression in HeLa cells	1
Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations	1
Response to the comments raised by Fernando Tricta	1
Meeting report of the first European biotransformation workshop	1
Utility of preclinical species for uncertainty assessment and correction of prediction of human volume of distribution using the Rodgers-Lukacova model	1
N, N -dimethyltryptamine forms oxygenated metabolites via CYP2D6 - an in vitro investigation	1
Through a computer monitor darkly: artificial intelligence in absorption, distribution, metabolism and excretion science	1
Beyond cytotoxic potency: disposition features required to design ADC payload	1
Metabolic profiling in liver microsomes and mice of E28, a potent FLT3 inhibitor	1
Genetic variants of aldehyde oxidase (AOX) 1 in cynomolgus and rhesus macaques	1
In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor	1
In vitro and in vivo evaluation of organic anion-transporting polypeptide 2B1-mediated pharmacokinetic interactions by apple polyphenols	1
Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets	1
Use of stable isotope labeled (SIL) antibodies in cassette dosing to improve pharmacokinetics screening efficiency of ADCs with novel cytotoxic payloads	1
Effect of capsaicin on breast cancer resistance protein (BCRP/Abcg2) and pharmacokinetics of probe substrates in rats	1
Evaluation of the effect of Bovis Calculus Artifactus on eight rat liver cytochrome P450 isozymes using LC-MS/MS and cocktail approach	1
Preclinical pharmacokinetic exploration of a novel osteoporotic quinazolinone-benzopyran-indole hybrid (S019-0385) using LC-MS/MS	1
Approaches to improve the translation of safety, pharmacokinetics and therapeutic index of ADCs	1
Identification of in vivo metabolites of a potential anti-rheumatoid arthritis compound, the quinazolinone derivative PD110, using ultra-high performance liquid chromatography coupled with Q-Exactive	1
Association of ABCG2 polymorphisms with susceptibility to anti-tuberculosis drug-induced hepatotoxicity in the Chinese population	1
Determination of enzymatic kinetics of metabolism of dimethoate and omethoate in rats and humans	1
Glutathione conjugation and protein modification resulting from metabolic activation of venlafaxinein vitroandin vivo	1
Bioanalytical approaches to support the development of antibody-oligonucleotide conjugate (AOC) therapeutic proteins	1
Upregulation of OATP1A2 in human oesophageal squamous cell carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis	1
Pharmacokinetics and pharmacodynamic interaction of bergamottin with atorvastatin in rats	1
Clinical pharmacokinetics of cefixime: a systematic review	1
Use of selective substrates and inhibitors to rapidly characterise batches of cryopreserved primary human hepatocytes for assessment of active uptake liability in drug discovery and development	1
A population pharmacokinetic-pharmacodynamic model of navtemadlin, its glucuronide metabolite (M1) and serum macrophage inhibitory cykokine-1 (MIC-1)	1
Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p -nitrophenol	1
Prevalence of SLCO1B1 single nucleotide variations and their association with hypercholesterolaemia in hypercholesterolemic patients in Gauteng, South Africa	1
Indirubin mediates adverse intestinal reactions in guinea pigs by downregulating the expression of AchE through AhR	1
One small step in time, one giant leap for DMPK kind – a CRO perspective of the evolving core discipline of drug development	1
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study	1
Agrimoniin inhibits the activity of CYP1A2, 2D6, and 3A4 in human liver microsomes	1
Association between pharmacokinetics of lenvatinib in healthy subjects and genetic polymorphisms of ABCB1 3435C>T and ABCB1 2677G>T/A	1
An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds	1
A general perspective for the conduct of radiolabelled distribution, metabolism, and excretion studies for antibody-drug conjugates	1
Development and validation of a highly sensitive and selective LC-MS/MS method for the determination of 15-hydroxylubiprostone in human plasma: application to a pharmacokinetic study in healthy Chines	1
The characterisation of the in vitro metabolism and transport of 6-hydroxykynurenic acid, an important constituent of Ginkgo biloba extracts	1
Investigation of pharmacokinetic properties of a PEGylated bilirubin nanoparticle in male Sprague-Dawley rats using liquid chromatography-quadrupole time-of-flight mass spectrometry	1
Interactions between cadmium and zinc on gene expression pattern of differentiation markers in MC3T3-E1 cell line	1
Intracellular activation of 4-hydroxycyclophosphamide into a DNA-alkylating agent in human leucocytes	1
Biochemical responses of the mussel Perna perna after exposure to environmental concentrations of the UV filter Benzophenone-3	1
Effect of genetic polymorphisms on the pharmacokinetics of gefitinib in healthy Chinese volunteers	1