Mechanisms of Ageing and Development

Papers
(The TQCC of Mechanisms of Ageing and Development is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)
ArticleCitations
Electrical brain activity in Centenarians: Neurophysiological EEG markers in resilient brain ageing139
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study98
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress84
The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs78
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT78
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice74
Editorial Board73
The role of cytokines/chemokines in an aging skin immune microenvironment71
Characterization of a natural model of adult mice with different rate of aging66
Impact of age and gender on glioblastoma onset, progression, and management55
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases54
Editorial Board50
Sex differences in neuroimmunoendocrine communication. Involvement on longevity42
Human astrocytes from healthy individuals and Alzheimer’s patients respond differently to Aβ1–42 oligomers, triggering distinct paths of reactivity and senescence40
Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years40
Mechanism of FTO-mediated m6A demethylation regulation of YAP1 in nucleus pulposus cell senescence38
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targe37
The role of mitochondria in cytokine and chemokine signalling during ageing36
Dietary ingredients inducing cellular senescence in animals and humans: A systematic review36
Molecular mechanisms and potential interventions during aging-associated sarcopenia35
Editorial: Aging and osteoporosis33
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways32
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis32
Senescence of skeletal stem cells and their contribution to age-related bone loss31
Methods of muscle atrophy analysis at the single-nucleus level31
Senescent cancer-associated fibroblasts in cancer progression: From formation to therapeutic opportunities31
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways30
Mitochondria-lysosome contacts in aging: A mechanistic interface linking organelle homeostasis and cellular decline30
Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity29
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Kl29
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response27
Vascular participation in bone healing: Implications related to advancing age and morbidity27
Corrigendum to “Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population” [M27
Vitisin B rejuvenates senescence via WBP2NL regulation26
Tendon homeostasis and regeneration: Interplay of cells, immune response, and bioactive compounds24
ELN regulates cellular senescence: Emerging hypothesis for a non-canonical role23
Towards defining optimal concentrations of micronutrients in adults to optimize health23
Living in endemic area for infectious diseases accelerates epigenetic age23
Senescence-associated tertiary lymphoid structures in Sjögren's disease model nishiura mice23
Decreased oxidative stress response and oxidant detoxification of skin during aging23
Inflammaging in geriatric liver disease: Mechanistic insights and therapeutic frontiers22
Prenatal glucocorticoid exposure and congenital abdominal wall defects: Involvement of CXCR4 – SDF-1 signaling21
Editorial Board21
Amyloid fil rouge from invertebrate up to human ageing: A focus on Alzheimer disease21
Expression of concern: Regulation of β-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer’s disease20
Functional significance of extracellular vesicles as mediators of cardiometabolic and cardiorenal diseases upon aging20
The effect of the demographic history on the evolution of senescence: A potential new test of the mutation accumulation theory20
The abundance change of age-regulated secreted proteins affects lifespan of C. elegans20
A novel platform for precise senolysis20
A role for long-lived nuclear envelope proteins in cardiac ageing20
Local cannabinoid receptor type-1 regulates glial cell activity and insulin-like growth factor-1 receptor signaling in the mediobasal hypothalamus19
Editorial Board19
Corrigendum to “CAR, mGPS and hs-mGPS: Which of these is the best gero-biomarker for age-related diseases? And for what clinical application?” [Mech. Aging Dev. 220 (2024) 111952]19
Curvilinear dose-response association of physical activity with clinically diagnosed stress: Prospective cohort with 74,000 individuals19
Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson’ s disease cohorts19
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury18
The TGF-β1-oxidative stress axis underlies accelerated senescence of endothelial cells exposed to serum from hypertensive patients18
Blood aging: From definition and mechanisms to clinical practice18
Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder18
Improving intestinal inflammaging to delay aging? A new perspective18
The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients18
The link between obesity and aging - insights into cardiac energy metabolism18
Interspecific interactions and aging: Prediction of gerogenic bacteria and critical human protein targets of microbial infections18
Ageing, metabolomics and palaeoanthropology: What can the fields learn from each other?17
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data17
Aging of the Colon – A Mechanistic View17
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 117
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?17
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites16
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age16
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses16
ANRIL modulates endothelial senescence and angiogenesis through SASP-driven miR146a regulation in age-related vascular dysfunction16
Cycloastragenol activation of telomerase improves β-Klotho protein level and attenuates age-related malfunctioning in ovarian tissues15
Circulating mitokines GDF-15 and FGF21 are associated with frailty, sarcopenia, and malnutrition in older adults: Evidence from the FRASNET study15
Editorial Board15
Editorial Board15
Lipids and the hallmarks of ageing: From pathology to interventions15
Circulating microRNAs and cross sectional and longitudinal measurements of physical functioning and frailty: An explorative study in older twins15
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome14
Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez614
Targeting senescence and inflammation in chronic destructive TNF-driven joint pathology14
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy14
Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components14
Fecal microbiota transplantation holds the secret to youth14
Dietary restriction mitigates cognitive impairments in a mouse model of SCA19/2214
Pro-Xylane alleviates ultraviolet-induced skin senescence through SGK1-mediated p21 ubiquitination and subcellular translocation14
Cellular senescence and premature aging in Down Syndrome13
The emerging importance of lymphangiogenesis in aging and aging-associated diseases13
Galectin-3-binding protein is a risk factor for diabetes, metabolic syndrome, and inflammation. Cross-sectional and longitudinal results from the InCHIANTI study13
Towards personalized nicotinamide mononucleotide (NMN) supplementation: Nicotinamide adenine dinucleotide (NAD) concentration13
Embryonic stem cell-derived extracellular vesicles alleviate ovarian dysfunction13
Hutchinson-Gilford progeria syndrome: Cardiovascular manifestations and treatment13
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus13
The influence of inflammation and frailty in the aging continuum13
Sex differences in adult lifespan and aging rate across mammals: A test of the ‘Mother Curse hypothesis’13
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