Mechanisms of Ageing and Development

Papers
(The TQCC of Mechanisms of Ageing and Development is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans141
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice99
Characterization of a natural model of adult mice with different rate of aging91
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study90
The role of cytokines/chemokines in an aging skin immune microenvironment86
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress77
Impact of age and gender on glioblastoma onset, progression, and management70
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy68
Strategies for late phase preclinical and early clinical trials of senolytics67
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease66
Brain aging mechanisms with mechanical manifestations62
Coenzyme Q10 supplementation – In ageing and disease60
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases55
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT55
Editorial Board51
The role of mitochondria in cytokine and chemokine signalling during ageing51
Age-related alterations and senescence of mesenchymal stromal cells: Implications for regenerative treatments of bones and joints50
Sex differences in neuroimmunoendocrine communication. Involvement on longevity50
Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years49
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targe48
Molecular mechanisms and potential interventions during aging-associated sarcopenia42
Senescence of skeletal stem cells and their contribution to age-related bone loss37
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways37
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis37
Recent advances in the discovery of senolytics36
Vascular participation in bone healing: Implications related to advancing age and morbidity36
Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity36
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Kl36
Editorial Board35
Living in endemic area for infectious diseases accelerates epigenetic age34
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response34
Decreased oxidative stress response and oxidant detoxification of skin during aging31
Inflammaging: The lesson of COVID-19 pandemic30
Prenatal glucocorticoid exposure and congenital abdominal wall defects: Involvement of CXCR4 – SDF-1 signaling30
Amyloid fil rouge from invertebrate up to human ageing: A focus on Alzheimer disease29
Editorial Board29
Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of28
The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients28
The effect of the demographic history on the evolution of senescence: A potential new test of the mutation accumulation theory28
Corrigendum to “CAR, mGPS and hs-mGPS: Which of these is the best gero-biomarker for age-related diseases? And for what clinical application?” [Mech. Aging Dev. 220 (2024) 111952]28
The abundance change of age-regulated secreted proteins affects lifespan of C. elegans28
Association between vitamin D status and physical performance in COVID-19 survivors: Results from the Gemelli against COVID-19 post-acute care project27
Improving intestinal inflammaging to delay aging? A new perspective27
Local cannabinoid receptor type-1 regulates glial cell activity and insulin-like growth factor-1 receptor signaling in the mediobasal hypothalamus26
Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox26
Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson’ s disease cohorts25
The link between obesity and aging - insights into cardiac energy metabolism25
Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder25
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses25
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives25
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury25
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 124
Toward a multidisciplinary science of aging biology24
Ferulic acid and hormesis: Biomedical and environmental implications24
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age23
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites23
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?22
Evaluation of senescent cells in intervertebral discs by lipofuscin staining22
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data22
MicroRNA profiles of human peripheral arteries and abdominal aorta in normal conditions: MicroRNAs-27a-5p, -139-5p and -155-5p emerge and in atheroma too22
Editorial Board21
Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue21
VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila21
Editorial Board21
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder21
A quantile frailty index without dichotomization20
The adult lifespan of the female honey bee (Apis mellifera): Metabolic rate, AGE pigment and the effect of dietary fatty acids20
New insights into molecular changes in skeletal muscle aging and disease: Differential alternative splicing and senescence19
Cycloastragenol activation of telomerase improves β-Klotho protein level and attenuates age-related malfunctioning in ovarian tissues19
Risks and rewards of targeting NAD+ homeostasis in the brain19
Caloric restriction enhances vascular tone of cerebral and mesenteric resistance arteries in aged rats18
Fatty acid desaturation is essential for C. elegans longevity at high temperature18
Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice18
Age-related activity of Poly (ADP-Ribose) Polymerase (PARP) in men with localized prostate cancer18
Lipids and the hallmarks of ageing: From pathology to interventions18
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy18
Genistein, a tool for geroscience18
Editorial Board17
Corrigendum to “Evaluation of senescent cells in intervertebral discs by lipofuscin staining” [Mech. Ageing Dev. 199 (2021) 1–9/111564]17
Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors17
The effect of physical exercise on functional brain network connectivity in older adults with and without cognitive impairment. A systematic review17
Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez617
Fecal microbiota transplantation holds the secret to youth17
Targeting senescence and inflammation in chronic destructive TNF-driven joint pathology16
Cellular senescence in vascular wall mesenchymal stromal cells, a possible contribution to the development of aortic aneurysm16
Hutchinson-Gilford progeria syndrome: Cardiovascular manifestations and treatment16
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome16
The role of senolytics in osteoporosis and other skeletal pathologies15
Sex differences in adult lifespan and aging rate across mammals: A test of the ‘Mother Curse hypothesis’15
Towards personalized nicotinamide mononucleotide (NMN) supplementation: Nicotinamide adenine dinucleotide (NAD) concentration15
Cellular senescence and premature aging in Down Syndrome15
Signs of diastolic dysfunction are graded by serum testosterone levels in aging C57BL/6 male mice15
Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components15
Ileal FXR-FGF15/19 signaling activation improves skeletal muscle loss in aged mice15
Progresses in both basic research and clinical trials of NAD+ in Parkinson’s disease15
Abnormal development of cerebral arteries and veins in offspring of experimentally preeclamptic rats: Potential role in perinatal stroke15
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