Mechanisms of Ageing and Development

Papers
(The TQCC of Mechanisms of Ageing and Development is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)
ArticleCitations
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice155
Characterization of a natural model of adult mice with different rate of aging109
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT99
The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs97
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study96
The role of cytokines/chemokines in an aging skin immune microenvironment85
Strategies for late phase preclinical and early clinical trials of senolytics80
Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans76
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease73
Impact of age and gender on glioblastoma onset, progression, and management71
Brain aging mechanisms with mechanical manifestations70
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy63
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress59
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases58
Editorial Board53
Sex differences in neuroimmunoendocrine communication. Involvement on longevity53
Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years52
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targe45
Molecular mechanisms and potential interventions during aging-associated sarcopenia45
Age-related alterations and senescence of mesenchymal stromal cells: Implications for regenerative treatments of bones and joints44
Dietary ingredients inducing cellular senescence in animals and humans: A systematic review41
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways39
The role of mitochondria in cytokine and chemokine signalling during ageing39
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways38
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Kl38
Editorial: Aging and osteoporosis37
Recent advances in the discovery of senolytics36
Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity35
Senescence of skeletal stem cells and their contribution to age-related bone loss35
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis34
Living in endemic area for infectious diseases accelerates epigenetic age33
Towards defining optimal concentrations of micronutrients in adults to optimize health33
ELN regulates cellular senescence: Emerging hypothesis for a non-canonical role33
Corrigendum to “Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population” [M32
Decreased oxidative stress response and oxidant detoxification of skin during aging31
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response30
Editorial Board28
Prenatal glucocorticoid exposure and congenital abdominal wall defects: Involvement of CXCR4 – SDF-1 signaling28
Amyloid fil rouge from invertebrate up to human ageing: A focus on Alzheimer disease28
Vascular participation in bone healing: Implications related to advancing age and morbidity28
Inflammaging: The lesson of COVID-19 pandemic27
Functional significance of extracellular vesicles as mediators of cardiometabolic and cardiorenal diseases upon aging27
Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of27
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury26
Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox26
Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder26
The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients26
Corrigendum to “CAR, mGPS and hs-mGPS: Which of these is the best gero-biomarker for age-related diseases? And for what clinical application?” [Mech. Aging Dev. 220 (2024) 111952]26
The effect of the demographic history on the evolution of senescence: A potential new test of the mutation accumulation theory26
Association between vitamin D status and physical performance in COVID-19 survivors: Results from the Gemelli against COVID-19 post-acute care project25
A novel platform for precise senolysis25
Local cannabinoid receptor type-1 regulates glial cell activity and insulin-like growth factor-1 receptor signaling in the mediobasal hypothalamus24
The abundance change of age-regulated secreted proteins affects lifespan of C. elegans24
Improving intestinal inflammaging to delay aging? A new perspective24
The link between obesity and aging - insights into cardiac energy metabolism23
Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson’ s disease cohorts23
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives23
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data22
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 122
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?22
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses22
MicroRNA profiles of human peripheral arteries and abdominal aorta in normal conditions: MicroRNAs-27a-5p, -139-5p and -155-5p emerge and in atheroma too22
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites22
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age21
Ageing, metabolomics and palaeoanthropology: What can the fields learn from each other?20
Interspecific interactions and aging: Prediction of gerogenic bacteria and critical human protein targets of microbial infections20
ANRIL modulates endothelial senescence and angiogenesis through SASP-driven miR146a regulation in age-related vascular dysfunction20
Evaluation of senescent cells in intervertebral discs by lipofuscin staining20
Editorial Board19
VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila19
Ferulic acid and hormesis: Biomedical and environmental implications19
The adult lifespan of the female honey bee (Apis mellifera): Metabolic rate, AGE pigment and the effect of dietary fatty acids18
Editorial Board18
Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue17
Genistein, a tool for geroscience17
Risks and rewards of targeting NAD+ homeostasis in the brain17
Cycloastragenol activation of telomerase improves β-Klotho protein level and attenuates age-related malfunctioning in ovarian tissues17
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder17
Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice17
A quantile frailty index without dichotomization17
Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors16
Lipids and the hallmarks of ageing: From pathology to interventions16
Editorial Board16
Fatty acid desaturation is essential for C. elegans longevity at high temperature16
Corrigendum to “Evaluation of senescent cells in intervertebral discs by lipofuscin staining” [Mech. Ageing Dev. 199 (2021) 1–9/111564]16
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy16
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome15
Hutchinson-Gilford progeria syndrome: Cardiovascular manifestations and treatment15
Fecal microbiota transplantation holds the secret to youth15
Targeting senescence and inflammation in chronic destructive TNF-driven joint pathology15
Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez615
Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids14
Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components14
Sex differences in adult lifespan and aging rate across mammals: A test of the ‘Mother Curse hypothesis’14
The role of senolytics in osteoporosis and other skeletal pathologies14
Towards personalized nicotinamide mononucleotide (NMN) supplementation: Nicotinamide adenine dinucleotide (NAD) concentration14
The influence of inflammation and frailty in the aging continuum14
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