Mechanisms of Ageing and Development

Papers
(The TQCC of Mechanisms of Ageing and Development is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)
ArticleCitations
Neprilysin expression and functions in development, ageing and disease103
TREM2, microglia, and Alzheimer’s disease93
Decreased serum levels of the inflammaging marker miR-146a are associated with clinical non-response to tocilizumab in COVID-19 patients92
Brain aging mechanisms with mechanical manifestations86
The conundrum of human immune system “senescence”73
Faces of cellular senescence in skin aging72
Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing69
Sex differences in frailty: Comparisons between humans and preclinical models69
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives65
Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls63
The complex interplay between depression and multimorbidity in late life: risks and pathways60
Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity57
Strategies for late phase preclinical and early clinical trials of senolytics55
Objectively assessed physical activity and sedentary behavior and global cognitive function in older adults: a systematic review51
Recent advances in the discovery of senolytics49
The role of cellular senescence in tissue repair and regeneration45
Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging45
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview44
Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions42
Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion41
Immunosenescence and COVID-1941
Coenzyme Q10 supplementation – In ageing and disease41
Age and Sex: Impact on adipose tissue metabolism and inflammation40
Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions38
The old guard: Age-related changes in microglia and their consequences38
Senolytic targets and new strategies for clearing senescent cells38
Sex differences in markers of oxidation and inflammation. Implications for ageing35
Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice35
Female reproductive senescence across mammals: A high diversity of patterns modulated by life history and mating traits34
Cellular senescence in the aging brain: A promising target for neurodegenerative diseases34
Ferulic acid and hormesis: Biomedical and environmental implications33
The balance between NAD+ biosynthesis and consumption in ageing32
Mitochondria and cellular redox state on the route from ageing to Alzheimer’s disease31
Senotherapeutics: Targeting senescent cells for the main age-related diseases30
What if there’s no such thing as “aging”?30
The senescence-associated secretory phenotype: Fueling a wound that never heals30
Luteolin and hormesis28
Evolving structure-function relations during aortic maturation and aging revealed by multiphoton microscopy26
miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction25
New insights into molecular changes in skeletal muscle aging and disease: Differential alternative splicing and senescence25
Specific features of the oldest old from the Longevity Blue Zones in Ikaria and Sardinia24
Inhibition of Cpt1a alleviates oxidative stress-induced chondrocyte senescence via regulating mitochondrial dysfunction and activating mitophagy24
The role of senolytics in osteoporosis and other skeletal pathologies24
Redox modulation of vitagenes via plant polyphenols and vitamin D: Novel insights for chemoprevention and therapeutic interventions based on organoid technology23
The role of lipid-based signalling in wound healing and senescence22
Routine laboratory parameters, including complete blood count, predict COVID-19 in-hospital mortality in geriatric patients22
The effect of physical exercise on functional brain network connectivity in older adults with and without cognitive impairment. A systematic review22
Molecular and neural adaptations to neuromuscular electrical stimulation; Implications for ageing muscle22
Microbiota-gut-brain axis and Alzheimer’s disease: Implications of the blood-brain barrier as an intervention target22
A role for estrogen in skin ageing and dermal biomechanics22
Sex/gender-related differences in inflammaging22
Klotho attenuated Doxorubicin-induced cardiomyopathy by alleviating Dynamin-related protein 1 - mediated mitochondrial dysfunction22
Targeting ER stress and calpain activation to reverse age-dependent mitochondrial damage in the heart21
Malnutrition is associated with poor trajectories of activities of daily living in geriatric rehabilitation inpatients: RESORT21
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence21
Entropy modulation of electroencephalographic signals in physiological aging21
Promises and challenges of senolytics in skin regeneration, pathology and ageing20
Age-related alterations and senescence of mesenchymal stromal cells: Implications for regenerative treatments of bones and joints20
A geroscience motivated approach to treat Alzheimer’s disease: Senolytics move to clinical trials20
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease20
The role of physical exercise in modulating peripheral inflammatory and neurotrophic biomarkers in older adults: A systematic review and meta-analysis20
Activatable senoprobes and senolytics: Novel strategies to detect and target senescent cells20
Associations of multimorbidity on frailty and dependence among an elderly rural population: Findings from the AHSETS study19
Supplementation with phosphatidylethanolamine confers anti-oxidant and anti-aging effects via hormesis and reduced insulin/IGF-1-like signaling in C. elegans19
Hyperbaric oxygen therapy restores cognitive function and hippocampal pathologies in both aging and aging-obese rats19
Autophagy and heat-shock response impair stress granule assembly during cellular senescence18
Effects of cellular senescence on metabolic pathways in non-immune and immune cells18
Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans18
Mitochondrial transplantation improves anxiety- and depression-like behaviors in aged stress-exposed rats18
Gut-brain axis through the lens of gut microbiota and their relationships with Alzheimer's disease pathology: Review and recommendations18
Impact of age and gender on glioblastoma onset, progression, and management18
Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology18
Molecular mechanisms of altered adult hippocampal neurogenesis in Alzheimer's disease18
Frailty and cytokines in preclinical models: Comparisons with humans18
Sestrin family – the stem controlling healthy ageing17
Association analysis framework of genetic and exposure risks for COVID-19 in middle-aged and elderly adults17
Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells17
Circulating miR-320b and miR-483-5p levels are associated with COVID-19 in-hospital mortality17
Age-related diseases, therapies and gut microbiome: A new frontier for healthy aging17
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy17
Counteracting aged DNA methylation states to combat ageing and age-related diseases17
Healthy ageing and Mediterranean diet: A focus on hormetic phytochemicals17
Integration of miRNA’s theranostic potential with nanotechnology: Promises and challenges for Parkinson’s disease therapeutics17
Identification of a novel senomorphic agent, avenanthramide C, via the suppression of the senescence-associated secretory phenotype17
Do motoneuron discharge rates slow with aging? A systematic review and meta-analysis17
Xenohormesis underlyes the anti-aging and healthy properties of olive polyphenols17
Ileal FXR-FGF15/19 signaling activation improves skeletal muscle loss in aged mice17
Reproductive aging and telomeres: Are women and men equally affected?17
Trimethylamine N-oxide (TMAO) drives insulin resistance and cognitive deficiencies in a senescence accelerated mouse model17
Gender-specific effects of pro-longevity interventions in Drosophila16
Genistein, a tool for geroscience16
Doxorubicin-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: The role of Quercetin in modulating these processes16
Cellular senescence and failure of myelin repair in multiple sclerosis16
Connecting vascular aging and frailty in Alzheimer’s disease16
CopA3 peptide induces permanent cell-cycle arrest in colorectal cancer cells16
Senescence in RASopathies, a possible novel contributor to a complex pathophenoype16
The use of Motor and Cognitive Dual-Task quantitative assessment on subjects with mild cognitive impairment: A systematic review15
Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue15
Inflammaging and neurodegenerative diseases: Role of NLRP3 inflammasome activation in brain atherosclerotic vascular disease15
Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox15
Multimorbidity networks of chronic obstructive pulmonary disease and heart failure in men and women: Evidence from the EpiChron Cohort15
Relationship between dietary factors and S-Klotho plasma levels in young sedentary healthy adults15
Male and female gonadal ageing: its impact on health span and life span15
Cardiovascular health is associated with the epigenetic clock in the Berlin Aging Study II (BASE-II)15
Frailty syndrome: A target for functional nutrients?15
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