Mechanisms of Ageing and Development

Papers
(The TQCC of Mechanisms of Ageing and Development is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)
ArticleCitations
Characterization of a natural model of adult mice with different rate of aging133
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT91
The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs73
Impact of age and gender on glioblastoma onset, progression, and management70
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice68
The role of cytokines/chemokines in an aging skin immune microenvironment67
Electrical brain activity in Centenarians: Neurophysiological EEG markers in resilient brain ageing66
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress65
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study65
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy61
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases61
Molecular mechanisms and potential interventions during aging-associated sarcopenia52
Editorial Board49
Dietary ingredients inducing cellular senescence in animals and humans: A systematic review49
Human astrocytes from healthy individuals and Alzheimer’s patients respond differently to Aβ1–42 oligomers, triggering distinct paths of reactivity and senescence48
Mechanism of FTO-mediated m6A demethylation regulation of YAP1 in nucleus pulposus cell senescence41
The role of mitochondria in cytokine and chemokine signalling during ageing39
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targe38
Sex differences in neuroimmunoendocrine communication. Involvement on longevity38
Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years37
Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity35
Editorial: Aging and osteoporosis35
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Kl34
Senescent cancer-associated fibroblasts in cancer progression: From formation to therapeutic opportunities34
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis33
Senescence of skeletal stem cells and their contribution to age-related bone loss32
Corrigendum to “Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population” [M31
Mitochondria-lysosome contacts in aging: A mechanistic interface linking organelle homeostasis and cellular decline31
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways31
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways31
Vascular participation in bone healing: Implications related to advancing age and morbidity31
Methods of muscle atrophy analysis at the single-nucleus level31
Living in endemic area for infectious diseases accelerates epigenetic age29
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response29
Vitisin B rejuvenates senescence via WBP2NL regulation29
ELN regulates cellular senescence: Emerging hypothesis for a non-canonical role27
Tendon homeostasis and regeneration: Interplay of cells, immune response, and bioactive compounds26
Towards defining optimal concentrations of micronutrients in adults to optimize health26
Decreased oxidative stress response and oxidant detoxification of skin during aging26
Expression of concern: Regulation of β-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer’s disease25
Inflammaging: The lesson of COVID-19 pandemic23
Prenatal glucocorticoid exposure and congenital abdominal wall defects: Involvement of CXCR4 – SDF-1 signaling23
Amyloid fil rouge from invertebrate up to human ageing: A focus on Alzheimer disease23
Editorial Board23
Inflammaging in geriatric liver disease: Mechanistic insights and therapeutic frontiers21
A novel platform for precise senolysis20
Local cannabinoid receptor type-1 regulates glial cell activity and insulin-like growth factor-1 receptor signaling in the mediobasal hypothalamus20
Improving intestinal inflammaging to delay aging? A new perspective20
Corrigendum to “CAR, mGPS and hs-mGPS: Which of these is the best gero-biomarker for age-related diseases? And for what clinical application?” [Mech. Aging Dev. 220 (2024) 111952]20
The effect of the demographic history on the evolution of senescence: A potential new test of the mutation accumulation theory20
Functional significance of extracellular vesicles as mediators of cardiometabolic and cardiorenal diseases upon aging20
Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder19
Editorial Board18
The link between obesity and aging - insights into cardiac energy metabolism18
The TGF-β1-oxidative stress axis underlies accelerated senescence of endothelial cells exposed to serum from hypertensive patients18
Curvilinear dose-response association of physical activity with clinically diagnosed stress: Prospective cohort with 74,000 individuals18
Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson’ s disease cohorts18
A role for long-lived nuclear envelope proteins in cardiac ageing18
The abundance change of age-regulated secreted proteins affects lifespan of C. elegans18
The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients18
Association between vitamin D status and physical performance in COVID-19 survivors: Results from the Gemelli against COVID-19 post-acute care project18
Circulating mitokines GDF-15 and FGF21 are associated with frailty, sarcopenia, and malnutrition in older adults: Evidence from the FRASNET study17
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury17
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age17
Ageing, metabolomics and palaeoanthropology: What can the fields learn from each other?17
Interspecific interactions and aging: Prediction of gerogenic bacteria and critical human protein targets of microbial infections17
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 117
Blood aging: From definition and mechanisms to clinical practice17
Aging of the Colon – A Mechanistic View17
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data16
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses16
Editorial Board16
ANRIL modulates endothelial senescence and angiogenesis through SASP-driven miR146a regulation in age-related vascular dysfunction16
Lipids and the hallmarks of ageing: From pathology to interventions16
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?16
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites16
VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila16
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder15
Circulating microRNAs and cross sectional and longitudinal measurements of physical functioning and frailty: An explorative study in older twins15
Fecal microbiota transplantation holds the secret to youth14
Genistein, a tool for geroscience14
Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez614
Editorial Board14
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome14
Cycloastragenol activation of telomerase improves β-Klotho protein level and attenuates age-related malfunctioning in ovarian tissues14
Towards personalized nicotinamide mononucleotide (NMN) supplementation: Nicotinamide adenine dinucleotide (NAD) concentration13
Sex differences in adult lifespan and aging rate across mammals: A test of the ‘Mother Curse hypothesis’13
Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors13
Targeting senescence and inflammation in chronic destructive TNF-driven joint pathology13
Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components13
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy13
Dietary restriction mitigates cognitive impairments in a mouse model of SCA19/2213
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus13
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