OOIR: Observatory of International Research

Papers

(The TQCC of Mechanisms of Ageing and Development is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
SIRT1 and aging related signaling pathways	298
Risk factors for predicting mortality in elderly patients with COVID-19: A review of clinical data in China	157
Decreased serum levels of the inflammaging marker miR-146a are associated with clinical non-response to tocilizumab in COVID-19 patients	85
Neprilysin expression and functions in development, ageing and disease	82
TREM2, microglia, and Alzheimer’s disease	74
Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing	65
Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework	65
The conundrum of human immune system “senescence”	62
Brain aging mechanisms with mechanical manifestations	55
The complex interplay between depression and multimorbidity in late life: risks and pathways	53
Faces of cellular senescence in skin aging	52
Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls	52
Oncogene-induced senescence: From biology to therapy	49
Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity	49
The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotype	49
Sex differences in frailty: Comparisons between humans and preclinical models	48
Strategies for late phase preclinical and early clinical trials of senolytics	47
Objectively assessed physical activity and sedentary behavior and global cognitive function in older adults: a systematic review	46
SIRT1 Regulation in Ageing and Obesity	43
Recent advances in the discovery of senolytics	42
Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions	38
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives	37
The role of cellular senescence in tissue repair and regeneration	36
Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging	36
Regulation and roles of mitophagy at synapses	36

Neuroinflammation in pathogenesis of Alzheimer’s disease: Phytochemicals as potential therapeutics	35
Immunosenescence and COVID-19	34
DNA methylation in Alzheimer’s disease: In brain and peripheral blood	34
Coenzyme Q10 supplementation – In ageing and disease	33
Associations between diet and handgrip strength: a cross-sectional study from UK Biobank	32
Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions	31
The old guard: Age-related changes in microglia and their consequences	31
Female reproductive senescence across mammals: A high diversity of patterns modulated by life history and mating traits	31
Senolytic targets and new strategies for clearing senescent cells	30
Mitochondria and cellular redox state on the route from ageing to Alzheimer’s disease	30
Ferulic acid and hormesis: Biomedical and environmental implications	30
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview	30
Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion	30
Age and Sex: Impact on adipose tissue metabolism and inflammation	29
The balance between NAD+ biosynthesis and consumption in ageing	28
Senotherapeutics: Targeting senescent cells for the main age-related diseases	28
Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice	27
Ageing as a risk factor for cerebral ischemia: Underlying mechanisms and therapy in animal models and in the clinic	27
Mechanisms of enhanced quiescence in neural stem cell aging	27
What if there’s no such thing as “aging”?	27
The senescence-associated secretory phenotype: Fueling a wound that never heals	26
The environment as a determinant of successful aging or frailty	26
Protective effects of carotenoid fucoxanthin in fibroblasts cellular senescence	25
Aging Fits the Disease Criteria of the International Classification of Diseases	25
Hallmarks of aging Drosophila intestinal stem cells	25
LncRNA TRPC7-AS1 regulates nucleus pulposus cellular senescence and ECM synthesis via competing with HPN for miR-4769-5p binding	24
The role of epigenetics and non-coding RNAs in autophagy: A new perspective for thorough understanding	24
Frailty—A promising concept to evaluate disease vulnerability	24
Luteolin and hormesis	24
Cellular senescence in the aging brain: A promising target for neurodegenerative diseases	24
New insights into molecular changes in skeletal muscle aging and disease: Differential alternative splicing and senescence	23
Untangling the complexity of multimorbidity with machine learning	22
A new model to investigate UVB-induced cellular senescence and pigmentation in melanocytes	22
Evolving structure-function relations during aortic maturation and aging revealed by multiphoton microscopy	22
Compounds that extend longevity are protective in neurodegenerative diseases and provide a novel treatment strategy for these devastating disorders	21
The mechanism of lncRNA H19 in fibrosis and its potential as novel therapeutic target	21
Genome-wide profiling and predicted significance of post-mortem brain microRNA in Alzheimer’s disease	21
The role of stem cell niche in intestinal aging	20
ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy	20
tBHP treatment as a model for cellular senescence and pollution-induced skin aging	19
The role of senolytics in osteoporosis and other skeletal pathologies	19
Specific features of the oldest old from the Longevity Blue Zones in Ikaria and Sardinia	19
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence	19
Aging, obese-insulin resistance, and bone remodeling	19
Sex differences in markers of oxidation and inflammation. Implications for ageing	19
Targeting ER stress and calpain activation to reverse age-dependent mitochondrial damage in the heart	19
The effect of physical exercise on functional brain network connectivity in older adults with and without cognitive impairment. A systematic review	19
Molecular and neural adaptations to neuromuscular electrical stimulation; Implications for ageing muscle	18
A role for estrogen in skin ageing and dermal biomechanics	18
Age-related alterations and senescence of mesenchymal stromal cells: Implications for regenerative treatments of bones and joints	18

Microbiota-gut-brain axis and Alzheimer’s disease: Implications of the blood-brain barrier as an intervention target	18
Redox modulation of vitagenes via plant polyphenols and vitamin D: Novel insights for chemoprevention and therapeutic interventions based on organoid technology	18
Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans	18
Promises and challenges of senolytics in skin regeneration, pathology and ageing	18
Autophagy and heat-shock response impair stress granule assembly during cellular senescence	18
Erythrocytes as markers of oxidative stress related pathologies	18
Regulation of cellular senescence by microRNAs	17
The Aging Imageomics Study: rationale, design and baseline characteristics of the study population	17
Hyperbaric oxygen therapy restores cognitive function and hippocampal pathologies in both aging and aging-obese rats	17
Roles of OCT4 in pathways of embryonic development and cancer progression	17
The role of lipid-based signalling in wound healing and senescence	17
A geroscience motivated approach to treat Alzheimer’s disease: Senolytics move to clinical trials	16
Associations of multimorbidity on frailty and dependence among an elderly rural population: Findings from the AHSETS study	16
Klotho attenuated Doxorubicin-induced cardiomyopathy by alleviating Dynamin-related protein 1 - mediated mitochondrial dysfunction	16
Stem cell aging: The upcoming era of proteins and metabolites	16
Activatable senoprobes and senolytics: Novel strategies to detect and target senescent cells	16
Trimethylamine N-oxide (TMAO) drives insulin resistance and cognitive deficiencies in a senescence accelerated mouse model	16
Nifedipine-induced AMPK activation alleviates senescence by increasing autophagy and suppressing of Ca2+ levels in vascular smooth muscle cells	16
Association analysis framework of genetic and exposure risks for COVID-19 in middle-aged and elderly adults	16
Routine laboratory parameters, including complete blood count, predict COVID-19 in-hospital mortality in geriatric patients	16
Aging, calcium channel signaling and vascular tone	16
Sestrin family – the stem controlling healthy ageing	15
Vascular ageing in hypertension: Focus on mitochondria	15
Identification of a novel senomorphic agent, avenanthramide C, via the suppression of the senescence-associated secretory phenotype	15
Supplementation with phosphatidylethanolamine confers anti-oxidant and anti-aging effects via hormesis and reduced insulin/IGF-1-like signaling in C. elegans	15
Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells	15
Long-lived post-mitotic cell aging: is a telomere clock at play?	15
Frailty syndrome: A target for functional nutrients?	15
Mitophagy and iron: two actors sharing the stage in age-associated neuronal pathologies	15
Malnutrition is associated with poor trajectories of activities of daily living in geriatric rehabilitation inpatients: RESORT	15
Molecular mechanisms of altered adult hippocampal neurogenesis in Alzheimer's disease	15
Facing multimorbidity in the precision medicine era	15
Calorie restriction improves aging-induced impairment of cognitive function in relation to deregulation of corticosterone status and brain regional GABA system	14
Entropy modulation of electroencephalographic signals in physiological aging	14
Relationship between dietary factors and S-Klotho plasma levels in young sedentary healthy adults	14
The role of physical exercise in modulating peripheral inflammatory and neurotrophic biomarkers in older adults: A systematic review and meta-analysis	14
Age-related diseases, therapies and gut microbiome: A new frontier for healthy aging	14
Inflammaging and neurodegenerative diseases: Role of NLRP3 inflammasome activation in brain atherosclerotic vascular disease	14
Inhibition of Cpt1a alleviates oxidative stress-induced chondrocyte senescence via regulating mitochondrial dysfunction and activating mitophagy	14
CopA3 peptide induces permanent cell-cycle arrest in colorectal cancer cells	14
Effects of cellular senescence on metabolic pathways in non-immune and immune cells	14
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease	14