Mechanisms of Ageing and Development

Article	Citations
SIRT1 and aging related signaling pathways	298
Risk factors for predicting mortality in elderly patients with COVID-19: A review of clinical data in China	157
Decreased serum levels of the inflammaging marker miR-146a are associated with clinical non-response to tocilizumab in COVID-19 patients	85
Neprilysin expression and functions in development, ageing and disease	82
TREM2, microglia, and Alzheimer’s disease	74
Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing	65
Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework	65
The conundrum of human immune system “senescence”	62
Brain aging mechanisms with mechanical manifestations	55
The complex interplay between depression and multimorbidity in late life: risks and pathways	53
Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls	52
Faces of cellular senescence in skin aging	52
The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotype	49
Oncogene-induced senescence: From biology to therapy	49
Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity	49
Sex differences in frailty: Comparisons between humans and preclinical models	48
Strategies for late phase preclinical and early clinical trials of senolytics	47
Objectively assessed physical activity and sedentary behavior and global cognitive function in older adults: a systematic review	46
SIRT1 Regulation in Ageing and Obesity	43
Recent advances in the discovery of senolytics	42
Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions	38
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives	37
Regulation and roles of mitophagy at synapses	36
The role of cellular senescence in tissue repair and regeneration	36
Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging	36

Neuroinflammation in pathogenesis of Alzheimer’s disease: Phytochemicals as potential therapeutics	35
DNA methylation in Alzheimer’s disease: In brain and peripheral blood	34
Immunosenescence and COVID-19	34
Coenzyme Q10 supplementation – In ageing and disease	33
Associations between diet and handgrip strength: a cross-sectional study from UK Biobank	32
Female reproductive senescence across mammals: A high diversity of patterns modulated by life history and mating traits	31
Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions	31
The old guard: Age-related changes in microglia and their consequences	31
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview	30
Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion	30
Senolytic targets and new strategies for clearing senescent cells	30
Mitochondria and cellular redox state on the route from ageing to Alzheimer’s disease	30
Ferulic acid and hormesis: Biomedical and environmental implications	30
Age and Sex: Impact on adipose tissue metabolism and inflammation	29
Senotherapeutics: Targeting senescent cells for the main age-related diseases	28
The balance between NAD+ biosynthesis and consumption in ageing	28
What if there’s no such thing as “aging”?	27
Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice	27
Ageing as a risk factor for cerebral ischemia: Underlying mechanisms and therapy in animal models and in the clinic	27
Mechanisms of enhanced quiescence in neural stem cell aging	27
The environment as a determinant of successful aging or frailty	26
The senescence-associated secretory phenotype: Fueling a wound that never heals	26
Hallmarks of aging Drosophila intestinal stem cells	25
Protective effects of carotenoid fucoxanthin in fibroblasts cellular senescence	25
Aging Fits the Disease Criteria of the International Classification of Diseases	25
Cellular senescence in the aging brain: A promising target for neurodegenerative diseases	24
LncRNA TRPC7-AS1 regulates nucleus pulposus cellular senescence and ECM synthesis via competing with HPN for miR-4769-5p binding	24
The role of epigenetics and non-coding RNAs in autophagy: A new perspective for thorough understanding	24
Frailty—A promising concept to evaluate disease vulnerability	24
Luteolin and hormesis	24
New insights into molecular changes in skeletal muscle aging and disease: Differential alternative splicing and senescence	23
Evolving structure-function relations during aortic maturation and aging revealed by multiphoton microscopy	22
Untangling the complexity of multimorbidity with machine learning	22
A new model to investigate UVB-induced cellular senescence and pigmentation in melanocytes	22
Genome-wide profiling and predicted significance of post-mortem brain microRNA in Alzheimer’s disease	21
Compounds that extend longevity are protective in neurodegenerative diseases and provide a novel treatment strategy for these devastating disorders	21
The mechanism of lncRNA H19 in fibrosis and its potential as novel therapeutic target	21
ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy	20
The role of stem cell niche in intestinal aging	20
Sex differences in markers of oxidation and inflammation. Implications for ageing	19
Targeting ER stress and calpain activation to reverse age-dependent mitochondrial damage in the heart	19
The effect of physical exercise on functional brain network connectivity in older adults with and without cognitive impairment. A systematic review	19
tBHP treatment as a model for cellular senescence and pollution-induced skin aging	19
The role of senolytics in osteoporosis and other skeletal pathologies	19
Specific features of the oldest old from the Longevity Blue Zones in Ikaria and Sardinia	19
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence	19
Aging, obese-insulin resistance, and bone remodeling	19
Promises and challenges of senolytics in skin regeneration, pathology and ageing	18
Autophagy and heat-shock response impair stress granule assembly during cellular senescence	18
Erythrocytes as markers of oxidative stress related pathologies	18

Molecular and neural adaptations to neuromuscular electrical stimulation; Implications for ageing muscle	18
A role for estrogen in skin ageing and dermal biomechanics	18
Age-related alterations and senescence of mesenchymal stromal cells: Implications for regenerative treatments of bones and joints	18
Microbiota-gut-brain axis and Alzheimer’s disease: Implications of the blood-brain barrier as an intervention target	18
Redox modulation of vitagenes via plant polyphenols and vitamin D: Novel insights for chemoprevention and therapeutic interventions based on organoid technology	18
Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans	18
The role of lipid-based signalling in wound healing and senescence	17
Regulation of cellular senescence by microRNAs	17
The Aging Imageomics Study: rationale, design and baseline characteristics of the study population	17
Hyperbaric oxygen therapy restores cognitive function and hippocampal pathologies in both aging and aging-obese rats	17
Roles of OCT4 in pathways of embryonic development and cancer progression	17
Activatable senoprobes and senolytics: Novel strategies to detect and target senescent cells	16
Nifedipine-induced AMPK activation alleviates senescence by increasing autophagy and suppressing of Ca2+ levels in vascular smooth muscle cells	16
Association analysis framework of genetic and exposure risks for COVID-19 in middle-aged and elderly adults	16
Routine laboratory parameters, including complete blood count, predict COVID-19 in-hospital mortality in geriatric patients	16
Associations of multimorbidity on frailty and dependence among an elderly rural population: Findings from the AHSETS study	16
Aging, calcium channel signaling and vascular tone	16
A geroscience motivated approach to treat Alzheimer’s disease: Senolytics move to clinical trials	16
Klotho attenuated Doxorubicin-induced cardiomyopathy by alleviating Dynamin-related protein 1 - mediated mitochondrial dysfunction	16
Trimethylamine N-oxide (TMAO) drives insulin resistance and cognitive deficiencies in a senescence accelerated mouse model	16
Stem cell aging: The upcoming era of proteins and metabolites	16
Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells	15
Long-lived post-mitotic cell aging: is a telomere clock at play?	15
Frailty syndrome: A target for functional nutrients?	15
Mitophagy and iron: two actors sharing the stage in age-associated neuronal pathologies	15
Malnutrition is associated with poor trajectories of activities of daily living in geriatric rehabilitation inpatients: RESORT	15
Molecular mechanisms of altered adult hippocampal neurogenesis in Alzheimer's disease	15
Facing multimorbidity in the precision medicine era	15
Sestrin family – the stem controlling healthy ageing	15
Vascular ageing in hypertension: Focus on mitochondria	15
Identification of a novel senomorphic agent, avenanthramide C, via the suppression of the senescence-associated secretory phenotype	15
Supplementation with phosphatidylethanolamine confers anti-oxidant and anti-aging effects via hormesis and reduced insulin/IGF-1-like signaling in C. elegans	15
The role of physical exercise in modulating peripheral inflammatory and neurotrophic biomarkers in older adults: A systematic review and meta-analysis	14
Age-related diseases, therapies and gut microbiome: A new frontier for healthy aging	14
Inflammaging and neurodegenerative diseases: Role of NLRP3 inflammasome activation in brain atherosclerotic vascular disease	14
Inhibition of Cpt1a alleviates oxidative stress-induced chondrocyte senescence via regulating mitochondrial dysfunction and activating mitophagy	14
CopA3 peptide induces permanent cell-cycle arrest in colorectal cancer cells	14
Effects of cellular senescence on metabolic pathways in non-immune and immune cells	14
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease	14
Calorie restriction improves aging-induced impairment of cognitive function in relation to deregulation of corticosterone status and brain regional GABA system	14
Entropy modulation of electroencephalographic signals in physiological aging	14
Relationship between dietary factors and S-Klotho plasma levels in young sedentary healthy adults	14
Mitophagy in cardiovascular homeostasis	13
A guide to senolytic intervention in neurodegenerative disease	13
Healthy ageing and Mediterranean diet: A focus on hormetic phytochemicals	13
A geroscience approach for Parkinson’s disease: Conceptual framework and design of PROPAG-AGEING project	13
Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue	13
Association between vitamin D status and physical performance in COVID-19 survivors: Results from the Gemelli against COVID-19 post-acute care project	13
Kynurenine induces an age-related phenotype in bone marrow stromal cells	13
Male and female gonadal ageing: its impact on health span and life span	13
Integration of miRNA’s theranostic potential with nanotechnology: Promises and challenges for Parkinson’s disease therapeutics	13
Genistein, a tool for geroscience	13
Frailty and cytokines in preclinical models: Comparisons with humans	13
Connecting vascular aging and frailty in Alzheimer’s disease	13
Do motoneuron discharge rates slow with aging? A systematic review and meta-analysis	13
Circulating miR-320b and miR-483-5p levels are associated with COVID-19 in-hospital mortality	13
miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction	13
Effects of lifelong exercise on age-related body composition, oxidative stress, inflammatory cytokines, and skeletal muscle proteome in rats	13
Type 5 phosphodiesterase (PDE5) and the vascular tree: From embryogenesis to aging and disease	13
Mitophagy during development and stress in C. elegans	12
Is metformin a geroprotector? A peek into the current clinical and experimental data	12
Systemic levels of C-reactive protein in patients with age-related macular degeneration: A systematic review with meta-analyses	12
Age-associated proinflammatory elastic fiber remodeling in large arteries	12
AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/STAT3 axis-mediated positive feedback loop	12
Gender-specific effects of pro-longevity interventions in Drosophila	12
Mitochondrial transplantation improves anxiety- and depression-like behaviors in aged stress-exposed rats	12
Multimorbidity networks of chronic obstructive pulmonary disease and heart failure in men and women: Evidence from the EpiChron Cohort	12
Circulating biomarkers of inflammaging as potential predictors of COVID-19 severe outcomes	12
Doxorubicin-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: The role of Quercetin in modulating these processes	12
The mitochondrial metabolic checkpoint in stem cell aging and rejuvenation	12
Skeletal muscle aging – Stem cells in the spotlight	12
Cellular senescence as a response to multiwalled carbon nanotube (MWCNT) exposure in human mesothelial cells	11
Sleep disorders and late-onset epilepsy of unknown origin: Understanding new trajectories to brain amyloidopathy	11
α-1 Adrenergic receptor antagonist doxazosin reverses hepatic stellate cells activation via induction of senescence	11
Mechanisms of neurodegeneration in Parkinson’s disease: keep neurons in the PINK1	11
Cellular senescence in vascular wall mesenchymal stromal cells, a possible contribution to the development of aortic aneurysm	11
Gut-brain axis through the lens of gut microbiota and their relationships with Alzheimer's disease pathology: Review and recommendations	11
The circuitry between ribosome biogenesis and translation in stem cell function and ageing	11
Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox	11
Sex/gender-related differences in inflammaging	11

Progresses in both basic research and clinical trials of NAD+ in Parkinson’s disease	11
Reproductive aging and telomeres: Are women and men equally affected?	11
Cellular senescence and failure of myelin repair in multiple sclerosis	11
Counteracting aged DNA methylation states to combat ageing and age-related diseases	11
The potential for complex computational models of aging	11
The potential of Senolytics in transplantation	11
Hippo signaling in regeneration and aging	11
Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease	11
Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of	10
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy	10
Xenohormesis underlyes the anti-aging and healthy properties of olive polyphenols	10
Proteodynamics and aging of eukaryotic cells	10
Novel metabolomics markers are associated with pre-clinical decline in hand grip strength in community-dwelling older adults	10
The mitochondria regulation of stem cell aging	10
Cardiovascular health is associated with the epigenetic clock in the Berlin Aging Study II (BASE-II)	9
Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle	9
MicroRNAs in hematopoietic stem cell aging	9
Prolonged hypoxia delays aging and preserves functionality of human amniotic fluid stem cells	9
Genetic deletion of TRPA1 receptor attenuates amyloid beta- 1-42 (Aβ1-42)-induced neurotoxicity in the mouse basal forebrain in vivo	9
IP6K3 and IPMK variations in LOAD and longevity: Evidence for a multifaceted signaling network at the crossroad between neurodegeneration and survival	9
Is poor self-rated sleep quality associated with elevated systemic inflammation in healthy older adults?	9
Evaluation of senescent cells in intervertebral discs by lipofuscin staining	9
Calorie restriction changes muscle satellite cell proliferation in a manner independent of metabolic modulation	9
Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology	9
The relationship between telomere length and putative markers of vascular ageing: A systematic review and meta-analysis	9
Towards an understanding of the mechanoreciprocity process in adipocytes and its perturbation with aging	9
Serum FOXO3A: A ray of hope for early diagnosis of Alzheimer’s disease	9
Effects of ten-week 30% caloric restriction on metabolic health and skeletal muscles of adult and old C57BL/6J mice	9
The use of geroprotectors to prevent multimorbidity: Opportunities and challenges	9
Derivation of a measure of physiological multisystem dysregulation: Results from WHAS and health ABC	9
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis	9
The biological relevance of pigment epithelium-derived factor on the path from aging to age-related disease	9
Evidence for the existence of A2AR-TrkB heteroreceptor complexes in the dorsal hippocampus of the rat brain: Potential implications of A2AR and TrkB interplay upon ageing	8
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder	8
Role and mechanism of TXNIP in ageing-related renal fibrosis	8
Age-dependent membrane release and degradation of full-length glycosylphosphatidylinositol-anchored proteins in rats	8
Absence of α-calcitonin gene-related peptide modulates bone remodeling properties of murine osteoblasts and osteoclasts in an age-dependent way	8
Cellular senescence in vivo: From cells to tissues to pathologies	8
The impact of ageing on lipid-mediated regulation of adult stem cell behavior and tissue homeostasis	8
Training primary care professionals in multimorbidity management: Educational assessment of the eMULTIPAP course	8
Sex and gender differences in Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis: A narrative review	8
Senescence in RASopathies, a possible novel contributor to a complex pathophenoype	8
Applications of adeno-associated virus vector-mediated gene delivery for neurodegenerative diseases and psychiatric diseases: Progress, advances, and challenges	8
Ileal FXR-FGF15/19 signaling activation improves skeletal muscle loss in aged mice	8
The Spt7 subunit of the SAGA complex is required for the regulation of lifespan in both dividing and nondividing yeast cells	8
Amyloid-β1-40 differentially stimulates proliferation, activation of oxidative stress and inflammatory responses in male and female hippocampal astrocyte cultures	8
Muscle stem cell aging: identifying ways to induce tissue rejuvenation	8
No association between frailty index and epigenetic clocks in Italian semi-supercentenarians	8
Effects of n-3 EPA and DHA supplementation on fat free mass and physical performance in elderly. A systematic review and meta-analysis of randomized clinical trial	8
The tumor suppression theory of aging	8
The use of Motor and Cognitive Dual-Task quantitative assessment on subjects with mild cognitive impairment: A systematic review	8
Which intervention is more effective in improving sarcopenia in older adults? A systematic review with meta-analysis of randomized controlled trials	7
Role of non-coding RNAs in age-related vascular cognitive impairment: An overview on diagnostic/prognostic value in Vascular Dementia and Vascular Parkinsonism	7
The emerging role of Cockayne group A and B proteins in ubiquitin/proteasome-directed protein degradation	7
Quantitative proteomics to study aging in rabbit liver	7
Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes	7
Impact of ageing, fall history and exercise on postural reflexes following unpredictable perturbations: A systematic review and meta-analyses	7
Cardioprotection of Klotho against myocardial infarction-induced heart failure through inducing autophagy	7
Mitochondrial biogenesis in organismal senescence and neurodegeneration	7
Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study	7
Abnormal development of cerebral arteries and veins in offspring of experimentally preeclamptic rats: Potential role in perinatal stroke	7
Cyanidin-3-O-glucoside promotes stress tolerance and lifespan extension of Caenorhabditis elegans exposed to polystyrene via DAF-16 pathway	7
Rodent diet aids and the fallacy of caloric restriction	7
Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch syndrome fibroblasts	7
Metformin mitigates stress-induced premature senescence by upregulating AMPKα at Ser485 phosphorylation induced SIRT3 expression and inactivating mitochondrial oxidants	7
Proliferation: Driver of HSC aging phenotypes?	7
The role of Sestrins in the regulation of the aging process	7
Genes and pathways involved in senescence bypass identified by functional genetic screens	7
Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia	7
The role of cytokines/chemokines in an aging skin immune microenvironment	7
Signaling pathways of dietary energy restriction and metabolism on brain physiology and in age-related neurodegenerative diseases	6
Impact of age and gender on glioblastoma onset, progression, and management	6
A promising biomarker of elevated galanin level in hypothalamus for osteoporosis risk in type 2 diabetes mellitus	6
Pan-tissue methylation aging clock: Recalibrated and a method to analyze and interpret the selected features	6
Prevalence of sarcopenic obesity based on newly proposed diagnostic criteria and functional outcomes in older adults undergoing rehabilitation	6
The role and biology of senescent cells in ageing-related tissue damage and repair	6
Short-term fasting differentially regulates PI3K/AkT/mTOR and ERK signalling in the rat hypothalamus	6
The SIRT1 activator SRT2104 promotes BMP9-induced osteogenic and angiogenic differentiation in mesenchymal stem cells	6
Calorie restriction changes the anxiety-like behaviour of ageing male Wistar rats in an onset- and duration-dependent manner	6
Stem cell aging	6
Advanced glycation end products in skeletal muscle health and sarcopenia: A systematic review of observational studies	6
Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice	6
Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway	6
Neurovascular manifestations in connective tissue diseases: The case of Marfan Syndrome	6
Its written all over your face: The molecular and physiological consequences of aging skin	6
Risks and rewards of targeting NAD+ homeostasis in the brain	6
Why we should use topological data analysis in ageing: Towards defining the “topological shape of ageing”	6
Cross-sectional associations of amyloid burden with semantic cognition in older adults without dementia: A systematic review and meta-analysis	6
Contribution of A-to-I RNA editing, M6A RNA Methylation, and Alternative Splicing to physiological brain aging and neurodegenerative diseases	6
Mitochondria (cross)talk with proteostatic mechanisms: Focusing on ageing and neurodegenerative diseases	6
The close link between the fetal programming imprinting and neurodegeneration in adulthood: The key role of “hemogenic endothelium” programming	6
Stem cell ageing of the root apical meristem of Arabidopsis thaliana	6
Long-term caloric restriction ameliorates T cell immunosenescence in mice	6