Mechanisms of Ageing and Development

Article	Citations
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 1	104
Exploring the interplay between stress mediators and skin microbiota in shaping age-related hallmarks: A review	101
Potential protein biomarkers in saliva for detection of frailty syndrome by targeted proteomics	86
Editorial Board	71
RNA-binding proteins in cellular senescence	70
From cue to meaning: The involvement of POLD1 gene in DNA replication, repair and aging	69
The sex-associated burden of atherosclerotic cardiovascular diseases: An update on prevention strategies	66
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT	57
Editorial Board	55
Impact of age and sex on hyperoxia-induced cardiovascular pathophysiology	51
Potential genetic biomarkers are found to be associated with both cognitive function and blood pressure: A bivariate genome-wide association analysis	49
Editorial Board	49
Sex-dependent deterioration of cardiac function and molecular alterations in age- and disease-associated RAGE overexpression	48
Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic	45
Trimethylamine N-oxide (TMAO) drives insulin resistance and cognitive deficiencies in a senescence accelerated mouse model	44
The role of cytokines/chemokines in an aging skin immune microenvironment	44
Endoplasmic reticulum stress and alterations of peroxiredoxins in aged hearts	42
Editorial Board	42
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study	42
Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion	41
Impact of ageing, fall history and exercise on postural reflexes following unpredictable perturbations: A systematic review and meta-analyses	38
The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop	38
Co-expression analysis identifies networks of miRNAs implicated in biological ageing and modulated by short-term interval training	38
Understanding the roles and regulation of mitochondrial microRNAs (MitomiRs) in neurodegenerative diseases: Current status and advances	35
Editorial Board	35

Moderators of skeletal muscle maintenance are compromised in sarcopenic obese mice	34
Gut-brain axis through the lens of gut microbiota and their relationships with Alzheimer's disease pathology: Review and recommendations	34
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice	30
Ageing: Not only an age-related issue	30
No association between frailty index and epigenetic clocks in Italian semi-supercentenarians	28
Sestrin2 plays a protective role in age-related hearing loss by inhibiting NLRP3-inflammasome activity	27
Role and mechanism of TXNIP in ageing-related renal fibrosis	26
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress	26
Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans	25
Inflammaging and neurodegenerative diseases: Role of NLRP3 inflammasome activation in brain atherosclerotic vascular disease	25
Calcium transferring from ER to mitochondria via miR-129/ITPR2 axis controls cellular senescence in vitro and in vivo	24
Toward a multidisciplinary science of aging biology	24
A blast from the past: To tame time with metformin	24
Senescence in RASopathies, a possible novel contributor to a complex pathophenoype	23
Ablation of miRNA-22 protects against obesity-induced adipocyte senescence and ameliorates metabolic disorders in middle-aged mice	23
Ageing-induced hypercontractility is related to functional enhancement of STIM/Orai and upregulation of Orai 3 in rat and human penile tissue	22
Strategies for late phase preclinical and early clinical trials of senolytics	22
Effect of age on the vascular proteome in middle cerebral arteries and mesenteric resistance arteries in mice	22
A new mechanistic insight into fate decisions during yeast cell aging process	22
Sex and gender differences in Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis: A narrative review	22
Impact of age and gender on glioblastoma onset, progression, and management	21
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age	21
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease	21
Rodent diet aids and the fallacy of caloric restriction	20
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy	20
Aging – What it is and how to measure it	20
Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle	20
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites	20
Exploring the interplay between metabolomics and genetics in Parkinson's disease: Insights from ongoing research and future avenues	20
Calorie restriction changes the anxiety-like behaviour of ageing male Wistar rats in an onset- and duration-dependent manner	20
Brain aging mechanisms with mechanical manifestations	19
Ferulic acid and hormesis: Biomedical and environmental implications	18
Age-associated proinflammatory elastic fiber remodeling in large arteries	18
Corrigendum to “Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6 J mice. A potential model of sporadic Alzheimer’s disease” [J. Mech. Agei	18
MicroRNA profiles of human peripheral arteries and abdominal aorta in normal conditions: MicroRNAs-27a-5p, -139-5p and -155-5p emerge and in atheroma too	18
Supplementation with phosphatidylethanolamine confers anti-oxidant and anti-aging effects via hormesis and reduced insulin/IGF-1-like signaling in C. elegans	18
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data	18
Frailty and cytokines in preclinical models: Comparisons with humans	18
Coenzyme Q10 supplementation – In ageing and disease	18
Prenatal exposure to CB2 receptors agonist differentially impacts male and female germ cells via histone modification	18
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases	17
Evaluation of senescent cells in intervertebral discs by lipofuscin staining	17
DYRK1B inhibition exerts senolytic effects on endothelial cells and rescues endothelial dysfunctions	17
The SIRT1 activator SRT2104 promotes BMP9-induced osteogenic and angiogenic differentiation in mesenchymal stem cells	17
Sirtuin 3 drives sex-specific responses to age-related changes in mouse embryonic fibroblasts	17
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?	17
Age-related diseases, therapies and gut microbiome: A new frontier for healthy aging	17
Characterization of a natural model of adult mice with different rate of aging	17
Adipose tissue senescence: Biological changes, hallmarks and therapeutic approaches	17
The impact of opioids on the hallmarks of ageing	17

Cardiovascular health is associated with the epigenetic clock in the Berlin Aging Study II (BASE-II)	17
Relationship between dietary factors and S-Klotho plasma levels in young sedentary healthy adults	17
What do we mean by “aging”? Questions and perspectives revealed by studies in Drosophila	16
Age-dependent energy metabolism and transcriptome changes in urine-derived stem cells	16
Editorial Board	16
Moderate dietary restriction delays the onset of age-associated sarcopenia in Caenorhabditis elegans due to reduced myosin UNC-54 degradation	16
Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice	16
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases	15
Editorial Board	15
Preserving the discreteness of deficits during coding leads to a lower frailty index in individuals living in long-term care	15
Sex and age differences in the association between high sensitivity C-reactive protein and all-cause mortality: A 12-year prospective cohort study	15
Editorial	15
Editorial Board	15
Frailty syndrome: A target for functional nutrients?	15
The biological relevance of pigment epithelium-derived factor on the path from aging to age-related disease	14
Editorial Board	14
New insights into molecular changes in skeletal muscle aging and disease: Differential alternative splicing and senescence	14
What researchers on ageing should know about multimorbidity, geroprotectors and artificial intelligence	14
VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila	14
Specific features of the oldest old from the Longevity Blue Zones in Ikaria and Sardinia	14
Editorial Board	14
Elucidating the role of chemokines in inflammaging associated atherosclerotic cardiovascular diseases	13
The impact of sleep and exercise on brain atrophy in mild cognitive impairment	13
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder	13
Molecular mechanisms and potential interventions during aging-associated sarcopenia	13
Protective effects of apigenin on the brain transcriptome with aging	13
Fatty acid desaturation is essential for C. elegans longevity at high temperature	13
Oral frailty indicators and cardio- and cerebrovascular diseases in older age: A systematic review	13
The close relationship between oocyte aging and telomere shortening, and possible interventions for telomere protection	13
Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue	12
Competing endogenous RNA networks were associated with fat accumulation in skeletal muscle of aged male mice	12
The age-related characteristics in bone microarchitecture, osteoclast distribution pattern, functional and transcriptomic alterations of BMSCs in mice	12
Long-term caloric restriction ameliorates T cell immunosenescence in mice	12
The adult lifespan of the female honey bee (Apis mellifera): Metabolic rate, AGE pigment and the effect of dietary fatty acids	11
Blood donation improves skin aging through the reduction of iron deposits and the increase of TGF-β1 in elderly skin	11
Risks and rewards of targeting NAD+ homeostasis in the brain	11
Evolving structure-function relations during aortic maturation and aging revealed by multiphoton microscopy	11
Molecular mechanisms of altered adult hippocampal neurogenesis in Alzheimer's disease	11
Lipids and the hallmarks of ageing: From pathology to interventions	11
Sex differences in neuroimmunoendocrine communication. Involvement on longevity	11
Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials	11
SIRT-associated attenuation of cellular senescence in vascular wall	11
Effects of cellular senescence on metabolic pathways in non-immune and immune cells	11
Editorial Board	11
The role of cellular senescence in tissue repair and regeneration	10
Relation of the kynurenine pathway with normal age: A systematic review	10
Understanding the (epi)genetic dysregulation in Parkinson's disease through an integrative brain competitive endogenous RNA network	10
Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes	10
Entropy modulation of electroencephalographic signals in physiological aging	10
Age-related alterations and senescence of mesenchymal stromal cells: Implications for regenerative treatments of bones and joints	10
A quantile frailty index without dichotomization	10
Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years	9
Amyloid-β1-40 differentially stimulates proliferation, activation of oxidative stress and inflammatory responses in male and female hippocampal astrocyte cultures	9
Deciphering Osteosarcopenia through the hallmarks of aging	9
Time-dependent effects of high-fat diet on cognition and cerebral insulin signaling: Window for recovery and potential therapeutic target	9
The role of mitochondria in cytokine and chemokine signalling during ageing	9
Genistein, a tool for geroscience	9
Editorial Board	9
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targe	9
Immunosenescence and COVID-19	9
Cycloastragenol activation of telomerase improves β-Klotho protein level and attenuates age-related malfunctioning in ovarian tissues	8
Luteolin and hormesis	8
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome	8
The Spt7 subunit of the SAGA complex is required for the regulation of lifespan in both dividing and nondividing yeast cells	8
Recent advances in the discovery of senolytics	8
Novel 18-norspirostane steroidal saponins: Extending lifespan and mitigating neurodegeneration through promotion of mitophagy and mitochondrial biogenesis in Caenorhabditis elegans	8
Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez6	8
Breathe it in – Spotlight on senescence and regeneration in the lung	8
Triplex and other DNA motifs show motif-specific associations with mitochondrial DNA deletions and species lifespan	8
Common and distinct metabolomic markers related to immune aging in Western European and East African populations	8
Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging	8
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Kl	8
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy	8
miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction	8
A role for estrogen in skin ageing and dermal biomechanics	8
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways	8
The cGAS-STING signaling pathway is modulated by urolithin A	7
Mechanisms of mitochondrial microRNA regulation in cardiovascular diseases	7
Comparative analysis of fat composition in marrow, serum, and muscle from aging C57BL6 mice	7
Senolytic targets and new strategies for clearing senescent cells	7

Genome-wide association analysis of cognitive function in Danish long-lived individuals	7
Editorial Board	7
Towards an understanding of the mechanoreciprocity process in adipocytes and its perturbation with aging	7
Effect of change of interleukin-6 over time on gait speed response: Results from the lifestyle interventions and independence for elders study	7
Reproductive aging and telomeres: Are women and men equally affected?	6
Integration of miRNA’s theranostic potential with nanotechnology: Promises and challenges for Parkinson’s disease therapeutics	6
Redox modulation of vitagenes via plant polyphenols and vitamin D: Novel insights for chemoprevention and therapeutic interventions based on organoid technology	6
Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus	6
Brain health promotion: Tactics within a strategic approach based upon valid, yet evolving scientific evidence	6
Restoring the endothelial barrier function in the elderly	6
A geroscience approach for Parkinson’s disease: Conceptual framework and design of PROPAG-AGEING project	6
IP6K3 and IPMK variations in LOAD and longevity: Evidence for a multifaceted signaling network at the crossroad between neurodegeneration and survival	6
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis	6
NFKB2 inhibits NRG1 transcription to affect nucleus pulposus cell degeneration and inflammation in intervertebral disc degeneration	6
Flow-mediated outward arterial remodeling in aging	6
Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors	6
Editorial Board	6
Caloric restriction enhances vascular tone of cerebral and mesenteric resistance arteries in aged rats	6
The effect of physical exercise on functional brain network connectivity in older adults with and without cognitive impairment. A systematic review	6
Interleukin-23 mediates the reduction of GADD45a expression to attenuate oxidative stress-induced cellular senescence in human fibroblasts	5
Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity	5
Corrigendum to “Evaluation of senescent cells in intervertebral discs by lipofuscin staining” [Mech. Ageing Dev. 199 (2021) 1–9/111564]	5
Corrigendum to “Molecular mechanisms in cognitive frailty: Potential therapeutic targets for oxygen-ozone treatment” [Mech. Ageing Dev. 186 (2020) 111210]	5
Unlocking diagnosis of sarcopenia: The role of circulating biomarkers – A clinical systematic review	5
Predicting negative health outcomes in older general practice patients with chronic illness: Rationale and development of the PROPERmed harmonized individual participant data database	5
Fecal microbiota transplantation holds the secret to youth	5
Convergence between brain aging and Alzheimer’s disease: Focus on mitochondria	5
Cardiac iron metabolism during aging – Role of inflammation and proteolysis	5
Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP	5
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview	5
Age-related activity of Poly (ADP-Ribose) Polymerase (PARP) in men with localized prostate cancer	5
Lifestyle factors and metabolomic aging biomarkers: Meta-analysis of cross-sectional and longitudinal associations in three prospective cohorts	5
Sarcopenia: A dive into metabolism to promote a multimodal, preventive, and regenerative approach	5
Cyanidin-3-O-glucoside promotes stress tolerance and lifespan extension of Caenorhabditis elegans exposed to polystyrene via DAF-16 pathway	5
The telomere connection between aging and cancer: The burden of replication stress and dysfunction	5
Role of chemokines in aging and age-related diseases	5
Cellular senescence in vascular wall mesenchymal stromal cells, a possible contribution to the development of aortic aneurysm	5
Senescence of skeletal stem cells and their contribution to age-related bone loss	5
Mitigating the effects of time in the heart and liver: The variable effects of short- and long-term caloric restriction	5
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus	4
The role of NAD+ metabolism in macrophages in age-related macular degeneration	4
The close link between the fetal programming imprinting and neurodegeneration in adulthood: The key role of “hemogenic endothelium” programming	4
Neurodegeneration & imperfect ageing: Technological limitations and challenges?	4
Editorial Board	4
Dietary restriction and ageing: Recent evolutionary perspectives	4
Editorial Board	4
The role of senolytics in osteoporosis and other skeletal pathologies	4
Sex differences in frailty: Comparisons between humans and preclinical models	4
The role and biology of senescent cells in ageing-related tissue damage and repair	4
Lens–specific conditional knockout of tropomyosin 1 gene in mice causes abnormal fiber differentiation and lens opacity	4
Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway	4
Progresses in both basic research and clinical trials of NAD+ in Parkinson’s disease	4
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response	4
Signs of diastolic dysfunction are graded by serum testosterone levels in aging C57BL/6 male mice	4
The emerging role of Cockayne group A and B proteins in ubiquitin/proteasome-directed protein degradation	4
Abnormal development of cerebral arteries and veins in offspring of experimentally preeclamptic rats: Potential role in perinatal stroke	4
Prevalence of sarcopenic obesity based on newly proposed diagnostic criteria and functional outcomes in older adults undergoing rehabilitation	4
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EDITORIAL Special Issue: The influence of biological sex in ageing	4
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Editorial Board	4