Mechanisms of Ageing and Development

Article	Citations
Neprilysin expression and functions in development, ageing and disease	103
TREM2, microglia, and Alzheimer’s disease	93
Decreased serum levels of the inflammaging marker miR-146a are associated with clinical non-response to tocilizumab in COVID-19 patients	92
Brain aging mechanisms with mechanical manifestations	86
The conundrum of human immune system “senescence”	73
Faces of cellular senescence in skin aging	72
Sex differences in frailty: Comparisons between humans and preclinical models	69
Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing	69
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives	65
Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls	63
The complex interplay between depression and multimorbidity in late life: risks and pathways	60
Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity	57
Strategies for late phase preclinical and early clinical trials of senolytics	55
Objectively assessed physical activity and sedentary behavior and global cognitive function in older adults: a systematic review	51
Recent advances in the discovery of senolytics	49
Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging	45
The role of cellular senescence in tissue repair and regeneration	45
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview	44
Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions	42
Coenzyme Q10 supplementation – In ageing and disease	41
Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion	41
Immunosenescence and COVID-19	41
Age and Sex: Impact on adipose tissue metabolism and inflammation	40
Senolytic targets and new strategies for clearing senescent cells	38
Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions	38

The old guard: Age-related changes in microglia and their consequences	38
Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice	35
Sex differences in markers of oxidation and inflammation. Implications for ageing	35
Cellular senescence in the aging brain: A promising target for neurodegenerative diseases	34
Female reproductive senescence across mammals: A high diversity of patterns modulated by life history and mating traits	34
Ferulic acid and hormesis: Biomedical and environmental implications	33
The balance between NAD+ biosynthesis and consumption in ageing	32
Mitochondria and cellular redox state on the route from ageing to Alzheimer’s disease	31
The senescence-associated secretory phenotype: Fueling a wound that never heals	30
Senotherapeutics: Targeting senescent cells for the main age-related diseases	30
What if there’s no such thing as “aging”?	30
Luteolin and hormesis	28
Evolving structure-function relations during aortic maturation and aging revealed by multiphoton microscopy	26
New insights into molecular changes in skeletal muscle aging and disease: Differential alternative splicing and senescence	25
miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction	25
The role of senolytics in osteoporosis and other skeletal pathologies	24
Specific features of the oldest old from the Longevity Blue Zones in Ikaria and Sardinia	24
Inhibition of Cpt1a alleviates oxidative stress-induced chondrocyte senescence via regulating mitochondrial dysfunction and activating mitophagy	24
Redox modulation of vitagenes via plant polyphenols and vitamin D: Novel insights for chemoprevention and therapeutic interventions based on organoid technology	23
Molecular and neural adaptations to neuromuscular electrical stimulation; Implications for ageing muscle	22
Microbiota-gut-brain axis and Alzheimer’s disease: Implications of the blood-brain barrier as an intervention target	22
A role for estrogen in skin ageing and dermal biomechanics	22
Sex/gender-related differences in inflammaging	22
Klotho attenuated Doxorubicin-induced cardiomyopathy by alleviating Dynamin-related protein 1 - mediated mitochondrial dysfunction	22
The role of lipid-based signalling in wound healing and senescence	22
Routine laboratory parameters, including complete blood count, predict COVID-19 in-hospital mortality in geriatric patients	22
The effect of physical exercise on functional brain network connectivity in older adults with and without cognitive impairment. A systematic review	22
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence	21
Entropy modulation of electroencephalographic signals in physiological aging	21
Targeting ER stress and calpain activation to reverse age-dependent mitochondrial damage in the heart	21
Malnutrition is associated with poor trajectories of activities of daily living in geriatric rehabilitation inpatients: RESORT	21
The role of physical exercise in modulating peripheral inflammatory and neurotrophic biomarkers in older adults: A systematic review and meta-analysis	20
Activatable senoprobes and senolytics: Novel strategies to detect and target senescent cells	20
Promises and challenges of senolytics in skin regeneration, pathology and ageing	20
Age-related alterations and senescence of mesenchymal stromal cells: Implications for regenerative treatments of bones and joints	20
A geroscience motivated approach to treat Alzheimer’s disease: Senolytics move to clinical trials	20
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease	20
Hyperbaric oxygen therapy restores cognitive function and hippocampal pathologies in both aging and aging-obese rats	19
Associations of multimorbidity on frailty and dependence among an elderly rural population: Findings from the AHSETS study	19
Supplementation with phosphatidylethanolamine confers anti-oxidant and anti-aging effects via hormesis and reduced insulin/IGF-1-like signaling in C. elegans	19
Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology	18
Molecular mechanisms of altered adult hippocampal neurogenesis in Alzheimer's disease	18
Frailty and cytokines in preclinical models: Comparisons with humans	18
Autophagy and heat-shock response impair stress granule assembly during cellular senescence	18
Effects of cellular senescence on metabolic pathways in non-immune and immune cells	18
Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans	18
Mitochondrial transplantation improves anxiety- and depression-like behaviors in aged stress-exposed rats	18
Gut-brain axis through the lens of gut microbiota and their relationships with Alzheimer's disease pathology: Review and recommendations	18
Impact of age and gender on glioblastoma onset, progression, and management	18
Healthy ageing and Mediterranean diet: A focus on hormetic phytochemicals	17

Integration of miRNA’s theranostic potential with nanotechnology: Promises and challenges for Parkinson’s disease therapeutics	17
Identification of a novel senomorphic agent, avenanthramide C, via the suppression of the senescence-associated secretory phenotype	17
Do motoneuron discharge rates slow with aging? A systematic review and meta-analysis	17
Sestrin family – the stem controlling healthy ageing	17
Xenohormesis underlyes the anti-aging and healthy properties of olive polyphenols	17
Ileal FXR-FGF15/19 signaling activation improves skeletal muscle loss in aged mice	17
Reproductive aging and telomeres: Are women and men equally affected?	17
Trimethylamine N-oxide (TMAO) drives insulin resistance and cognitive deficiencies in a senescence accelerated mouse model	17
Association analysis framework of genetic and exposure risks for COVID-19 in middle-aged and elderly adults	17
Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells	17
Circulating miR-320b and miR-483-5p levels are associated with COVID-19 in-hospital mortality	17
Age-related diseases, therapies and gut microbiome: A new frontier for healthy aging	17
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy	17
Counteracting aged DNA methylation states to combat ageing and age-related diseases	17
Gender-specific effects of pro-longevity interventions in Drosophila	16
Genistein, a tool for geroscience	16
Doxorubicin-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: The role of Quercetin in modulating these processes	16
Cellular senescence and failure of myelin repair in multiple sclerosis	16
Connecting vascular aging and frailty in Alzheimer’s disease	16
CopA3 peptide induces permanent cell-cycle arrest in colorectal cancer cells	16
Senescence in RASopathies, a possible novel contributor to a complex pathophenoype	16
Male and female gonadal ageing: its impact on health span and life span	15
Cardiovascular health is associated with the epigenetic clock in the Berlin Aging Study II (BASE-II)	15
Frailty syndrome: A target for functional nutrients?	15
The use of Motor and Cognitive Dual-Task quantitative assessment on subjects with mild cognitive impairment: A systematic review	15
Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue	15
Inflammaging and neurodegenerative diseases: Role of NLRP3 inflammasome activation in brain atherosclerotic vascular disease	15
Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox	15
Multimorbidity networks of chronic obstructive pulmonary disease and heart failure in men and women: Evidence from the EpiChron Cohort	15
Relationship between dietary factors and S-Klotho plasma levels in young sedentary healthy adults	15
Circulating biomarkers of inflammaging as potential predictors of COVID-19 severe outcomes	14
Kynurenine induces an age-related phenotype in bone marrow stromal cells	14
Cardioprotection of Klotho against myocardial infarction-induced heart failure through inducing autophagy	14
A guide to senolytic intervention in neurodegenerative disease	14
Association between vitamin D status and physical performance in COVID-19 survivors: Results from the Gemelli against COVID-19 post-acute care project	14
The potential for complex computational models of aging	14
α-1 Adrenergic receptor antagonist doxazosin reverses hepatic stellate cells activation via induction of senescence	13
Cellular senescence in vascular wall mesenchymal stromal cells, a possible contribution to the development of aortic aneurysm	13
Sex and gender differences in Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis: A narrative review	13
Applications of adeno-associated virus vector-mediated gene delivery for neurodegenerative diseases and psychiatric diseases: Progress, advances, and challenges	13
Prevalence of sarcopenic obesity based on newly proposed diagnostic criteria and functional outcomes in older adults undergoing rehabilitation	13
A geroscience approach for Parkinson’s disease: Conceptual framework and design of PROPAG-AGEING project	13
Age-associated proinflammatory elastic fiber remodeling in large arteries	13
Metformin mitigates stress-induced premature senescence by upregulating AMPKα at Ser485 phosphorylation induced SIRT3 expression and inactivating mitochondrial oxidants	13
Progresses in both basic research and clinical trials of NAD+ in Parkinson’s disease	13
Amyloid-β1-40 differentially stimulates proliferation, activation of oxidative stress and inflammatory responses in male and female hippocampal astrocyte cultures	13
Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of	12
Long-term caloric restriction ameliorates T cell immunosenescence in mice	12
The potential of Senolytics in transplantation	12
Training primary care professionals in multimorbidity management: Educational assessment of the eMULTIPAP course	12
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis	12
Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch syndrome fibroblasts	12
Sleep disorders and late-onset epilepsy of unknown origin: Understanding new trajectories to brain amyloidopathy	11
Cyanidin-3-O-glucoside promotes stress tolerance and lifespan extension of Caenorhabditis elegans exposed to polystyrene via DAF-16 pathway	11
Cellular senescence as a response to multiwalled carbon nanotube (MWCNT) exposure in human mesothelial cells	11
Proteodynamics and aging of eukaryotic cells	11
Triplex and other DNA motifs show motif-specific associations with mitochondrial DNA deletions and species lifespan	11
Impact of ageing, fall history and exercise on postural reflexes following unpredictable perturbations: A systematic review and meta-analyses	11
The relationship between telomere length and putative markers of vascular ageing: A systematic review and meta-analysis	11
Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes	11
Evaluation of senescent cells in intervertebral discs by lipofuscin staining	11
Novel metabolomics markers are associated with pre-clinical decline in hand grip strength in community-dwelling older adults	10
Sex differences in neuromuscular disorders	10
Is poor self-rated sleep quality associated with elevated systemic inflammation in healthy older adults?	10
No association between frailty index and epigenetic clocks in Italian semi-supercentenarians	10
Effects of n-3 EPA and DHA supplementation on fat free mass and physical performance in elderly. A systematic review and meta-analysis of randomized clinical trial	10
Contribution of A-to-I RNA editing, M6A RNA Methylation, and Alternative Splicing to physiological brain aging and neurodegenerative diseases	10
Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia	10
The biological relevance of pigment epithelium-derived factor on the path from aging to age-related disease	10
Role and mechanism of TXNIP in ageing-related renal fibrosis	10
The use of geroprotectors to prevent multimorbidity: Opportunities and challenges	10
Age-associated anatomical and physiological alterations in Caenorhabditis elegans	10
Towards an understanding of the mechanoreciprocity process in adipocytes and its perturbation with aging	10
Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle	10
The role of cytokines/chemokines in an aging skin immune microenvironment	10
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder	9
Calorie restriction changes muscle satellite cell proliferation in a manner independent of metabolic modulation	9
Exogenous Klotho ameliorates extracellular matrix degradation and angiogenesis in intervertebral disc degeneration via inhibition of the Rac1/PAK1/MMP-2 signaling axis	9
IP6K3 and IPMK variations in LOAD and longevity: Evidence for a multifaceted signaling network at the crossroad between neurodegeneration and survival	9
Involvement of miRNA on epigenetics landscape of Parkinson's disease: From pathogenesis to therapeutics	9

Genes and pathways involved in senescence bypass identified by functional genetic screens	9
The Spt7 subunit of the SAGA complex is required for the regulation of lifespan in both dividing and nondividing yeast cells	9
Advanced glycation end products in skeletal muscle health and sarcopenia: A systematic review of observational studies	9
NFKB2 inhibits NRG1 transcription to affect nucleus pulposus cell degeneration and inflammation in intervertebral disc degeneration	9
Which intervention is more effective in improving sarcopenia in older adults? A systematic review with meta-analysis of randomized controlled trials	8
The emerging role of Cockayne group A and B proteins in ubiquitin/proteasome-directed protein degradation	8
Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway	8
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome	8
The tumor suppression theory of aging	8
Sex-specific effects of high-fat diet on rat brain glucose metabolism and early-onset dementia symptoms	8
Abnormal development of cerebral arteries and veins in offspring of experimentally preeclamptic rats: Potential role in perinatal stroke	8
Risks and rewards of targeting NAD+ homeostasis in the brain	8
β-Amyloid promotes platelet activation and activated platelets act as bridge between risk factors and Alzheimer’s disease	8
Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice	8
The role and biology of senescent cells in ageing-related tissue damage and repair	8
Short-term fasting differentially regulates PI3K/AkT/mTOR and ERK signalling in the rat hypothalamus	8
Calorie restriction changes the anxiety-like behaviour of ageing male Wistar rats in an onset- and duration-dependent manner	8
The bright and dark side of skin senescence. Could skin rejuvenation anti-senescence interventions become a "bright" new strategy for the prevention of age-related skin pathologies?	7
Moderators of skeletal muscle maintenance are compromised in sarcopenic obese mice	7
Role of cytokines and reactive oxygen species in brain aging	7
Dietary restriction and ageing: Recent evolutionary perspectives	7
Cellular and molecular features of senescence in acute lung injury	7
The SIRT1 activator SRT2104 promotes BMP9-induced osteogenic and angiogenic differentiation in mesenchymal stem cells	7
Rodent diet aids and the fallacy of caloric restriction	7
Cross-sectional associations of amyloid burden with semantic cognition in older adults without dementia: A systematic review and meta-analysis	7
Stem cell aging	7
Fecal microbiota transplantation holds the secret to youth	7
Sex differences in neuroimmunoendocrine communication. Involvement on longevity	7
Effect of age on the vascular proteome in middle cerebral arteries and mesenteric resistance arteries in mice	7
Derivation and comprehensive analysis of ageing-related genes in intervertebral disc degeneration for prediction and immunology	7
Current senolytics: Mode of action, efficacy and limitations, and their future	7
Age, sex, and frailty modify the expression of common reference genes in skeletal muscle from ageing mice	6
Pseudoginsenoside-F11 ameliorates okadiac acid-induced learning and memory impairment in rats via modulating protein phosphatase 2A	6
Cellular senescence and premature aging in Down Syndrome	6
Breathe it in – Spotlight on senescence and regeneration in the lung	6
Signaling pathways of dietary energy restriction and metabolism on brain physiology and in age-related neurodegenerative diseases	6
In vivo clonal analysis of aging hematopoietic stem cells	6
A blast from the past: To tame time with metformin	6
Pan-tissue methylation aging clock: Recalibrated and a method to analyze and interpret the selected features	6
Long-term tobacco exposure and immunosenescence: Paradoxical effects on T-cells telomere length and telomerase activity	6
Impact of air pollution on cardiovascular aging	6
Mechanisms of adipose tissue extracellular matrix alterations in an in vitro model of adipocytes hypoxia and aging	6
DYRK1B inhibition exerts senolytic effects on endothelial cells and rescues endothelial dysfunctions	6
Ageing: Not only an age-related issue	6
A promising biomarker of elevated galanin level in hypothalamus for osteoporosis risk in type 2 diabetes mellitus	6
Methylation of melatonin receptors in patients with unipolar and bipolar depression	6
The close link between the fetal programming imprinting and neurodegeneration in adulthood: The key role of “hemogenic endothelium” programming	6
Signs of diastolic dysfunction are graded by serum testosterone levels in aging C57BL/6 male mice	6
Protective effects of apigenin on the brain transcriptome with aging	6
Ablation of miRNA-22 protects against obesity-induced adipocyte senescence and ameliorates metabolic disorders in middle-aged mice	6
Why we should use topological data analysis in ageing: Towards defining the “topological shape of ageing”	6