Mechanisms of Ageing and Development

Article	Citations
Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans	141
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice	99
Characterization of a natural model of adult mice with different rate of aging	91
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study	90
The role of cytokines/chemokines in an aging skin immune microenvironment	86
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress	77
Impact of age and gender on glioblastoma onset, progression, and management	70
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy	68
Strategies for late phase preclinical and early clinical trials of senolytics	67
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease	66
Brain aging mechanisms with mechanical manifestations	62
Coenzyme Q10 supplementation – In ageing and disease	60
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases	55
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT	55
Editorial Board	51
The role of mitochondria in cytokine and chemokine signalling during ageing	51
Age-related alterations and senescence of mesenchymal stromal cells: Implications for regenerative treatments of bones and joints	50
Sex differences in neuroimmunoendocrine communication. Involvement on longevity	50
Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years	49
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targe	48
Molecular mechanisms and potential interventions during aging-associated sarcopenia	42
Senescence of skeletal stem cells and their contribution to age-related bone loss	37
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways	37
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis	37
Recent advances in the discovery of senolytics	36

Vascular participation in bone healing: Implications related to advancing age and morbidity	36
Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity	36
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Kl	36
Editorial Board	35
Living in endemic area for infectious diseases accelerates epigenetic age	34
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response	34
Decreased oxidative stress response and oxidant detoxification of skin during aging	31
Prenatal glucocorticoid exposure and congenital abdominal wall defects: Involvement of CXCR4 – SDF-1 signaling	30
Inflammaging: The lesson of COVID-19 pandemic	30
Amyloid fil rouge from invertebrate up to human ageing: A focus on Alzheimer disease	29
Editorial Board	29
The abundance change of age-regulated secreted proteins affects lifespan of C. elegans	28
Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of	28
The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients	28
The effect of the demographic history on the evolution of senescence: A potential new test of the mutation accumulation theory	28
Corrigendum to “CAR, mGPS and hs-mGPS: Which of these is the best gero-biomarker for age-related diseases? And for what clinical application?” [Mech. Aging Dev. 220 (2024) 111952]	28
Association between vitamin D status and physical performance in COVID-19 survivors: Results from the Gemelli against COVID-19 post-acute care project	27
Improving intestinal inflammaging to delay aging? A new perspective	27
Local cannabinoid receptor type-1 regulates glial cell activity and insulin-like growth factor-1 receptor signaling in the mediobasal hypothalamus	26
Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox	26
Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson’ s disease cohorts	25
The link between obesity and aging - insights into cardiac energy metabolism	25
Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder	25
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses	25
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives	25
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury	25
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 1	24
Toward a multidisciplinary science of aging biology	24
Ferulic acid and hormesis: Biomedical and environmental implications	24
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age	23
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites	23
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?	22
Evaluation of senescent cells in intervertebral discs by lipofuscin staining	22
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data	22
MicroRNA profiles of human peripheral arteries and abdominal aorta in normal conditions: MicroRNAs-27a-5p, -139-5p and -155-5p emerge and in atheroma too	22
Editorial Board	21
Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue	21
VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila	21
Editorial Board	21
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder	21
The adult lifespan of the female honey bee (Apis mellifera): Metabolic rate, AGE pigment and the effect of dietary fatty acids	20
A quantile frailty index without dichotomization	20
Risks and rewards of targeting NAD+ homeostasis in the brain	19
New insights into molecular changes in skeletal muscle aging and disease: Differential alternative splicing and senescence	19
Cycloastragenol activation of telomerase improves β-Klotho protein level and attenuates age-related malfunctioning in ovarian tissues	19
Caloric restriction enhances vascular tone of cerebral and mesenteric resistance arteries in aged rats	18
Fatty acid desaturation is essential for C. elegans longevity at high temperature	18
Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice	18
Age-related activity of Poly (ADP-Ribose) Polymerase (PARP) in men with localized prostate cancer	18
Lipids and the hallmarks of ageing: From pathology to interventions	18

Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy	18
Genistein, a tool for geroscience	18
Editorial Board	17
Corrigendum to “Evaluation of senescent cells in intervertebral discs by lipofuscin staining” [Mech. Ageing Dev. 199 (2021) 1–9/111564]	17
Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors	17
The effect of physical exercise on functional brain network connectivity in older adults with and without cognitive impairment. A systematic review	17
Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez6	17
Fecal microbiota transplantation holds the secret to youth	17
Targeting senescence and inflammation in chronic destructive TNF-driven joint pathology	16
Cellular senescence in vascular wall mesenchymal stromal cells, a possible contribution to the development of aortic aneurysm	16
Hutchinson-Gilford progeria syndrome: Cardiovascular manifestations and treatment	16
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome	16
Signs of diastolic dysfunction are graded by serum testosterone levels in aging C57BL/6 male mice	15
Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components	15
Ileal FXR-FGF15/19 signaling activation improves skeletal muscle loss in aged mice	15
Progresses in both basic research and clinical trials of NAD+ in Parkinson’s disease	15
Abnormal development of cerebral arteries and veins in offspring of experimentally preeclamptic rats: Potential role in perinatal stroke	15
Cellular senescence and premature aging in Down Syndrome	15
The role of senolytics in osteoporosis and other skeletal pathologies	15
Sex differences in adult lifespan and aging rate across mammals: A test of the ‘Mother Curse hypothesis’	15
Towards personalized nicotinamide mononucleotide (NMN) supplementation: Nicotinamide adenine dinucleotide (NAD) concentration	15
Senolytic drugs: Beyond the promise and the hype	14
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus	14
Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids	14
The emerging importance of lymphangiogenesis in aging and aging-associated diseases	14
The influence of inflammation and frailty in the aging continuum	13
Age-associated anatomical and physiological alterations in Caenorhabditis elegans	13
EDITORIAL Special Issue: The influence of biological sex in ageing	13
Single-cell analysis of human peripheral blood reveals high immune response activity in successful ageing individuals	13
Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4	13
Senotherapeutics: Targeting senescent cells for the main age-related diseases	13
The tumor suppression theory of aging	13
Differential Plin5 response to high-fat diet in cardiomyocytes isolated from young and aged mice	13
SuperAgers and centenarians, dynamics of healthy ageing with cognitive resilience	12
Doxorubicin-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: The role of Quercetin in modulating these processes	12
The potential of Senolytics in transplantation	12
A guide to senolytic intervention in neurodegenerative disease	12
Social environment improves the cytokine profile and lymphoproliferative response in chronologically old and prematurely aging mice	11
Inflammaging score as a potential prognostic tool for cancer: A population-based cohort study	11
Editorial Board	11
In the land of not-unhappiness: On the state-of-the-art of targeting aging and age-related diseases by biomedical research	11
Deuterated polyunsaturated fatty acids provided protection against oxidative stress in ocular fibroblasts derived from glaucoma patients	11
Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology	11
Analysis of representative mutants for key DNA repair pathways on healthspan in Caenorhabditis elegans	11
miR-26a deficiency is associated with bone loss and reduced muscle strength but does not affect severity of cartilage damage in osteoarthritis	11
Cardioprotection of Klotho against myocardial infarction-induced heart failure through inducing autophagy	10
Editorial Board	10
Ageing: Not only an age-related issue	10
Counteracting aged DNA methylation states to combat ageing and age-related diseases	10
Editorial Board	10
Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions	10
Do motoneuron discharge rates slow with aging? A systematic review and meta-analysis	10
Ablation of miRNA-22 protects against obesity-induced adipocyte senescence and ameliorates metabolic disorders in middle-aged mice	10
Role and mechanism of TXNIP in ageing-related renal fibrosis	9
Editorial Board	9
Frailty and cytokines in preclinical models: Comparisons with humans	9
Age-associated proinflammatory elastic fiber remodeling in large arteries	9
Endoplasmic reticulum stress and alterations of peroxiredoxins in aged hearts	9
Mangiferin protects mesenchymal stem cells against DNA damage and cellular aging via SIRT1 activation	9
Exploring the interplay between stress mediators and skin microbiota in shaping age-related hallmarks: A review	9
Corrigendum to “Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6 J mice. A potential model of sporadic Alzheimer’s disease” [J. Mech. Agei	9
Editorial Board	9
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases	9
No association between frailty index and epigenetic clocks in Italian semi-supercentenarians	9
Specific features of the oldest old from the Longevity Blue Zones in Ikaria and Sardinia	8
Immunosenescence and COVID-19	8
Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP	8
Comparative analysis of fat composition in marrow, serum, and muscle from aging C57BL6 mice	8
Entropy modulation of electroencephalographic signals in physiological aging	8
What do we mean by “aging”? Questions and perspectives revealed by studies in Drosophila	8
Integration of miRNA’s theranostic potential with nanotechnology: Promises and challenges for Parkinson’s disease therapeutics	8
Common and distinct metabolomic markers related to immune aging in Western European and East African populations	8
Relation of the kynurenine pathway with normal age: A systematic review	8
Competing endogenous RNA networks were associated with fat accumulation in skeletal muscle of aged male mice	8
Interleukin-23 mediates the reduction of GADD45a expression to attenuate oxidative stress-induced cellular senescence in human fibroblasts	8
Redox modulation of vitagenes via plant polyphenols and vitamin D: Novel insights for chemoprevention and therapeutic interventions based on organoid technology	7
The cGAS-STING signaling pathway is modulated by urolithin A	7
New frontiers in ageing and longevity: Sex and gender medicine	7
miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction	7
Differential effects of lifespan-extending genetic manipulations in an animal model of MJD/SCA3.	7

Vascular ageing and the related complications in the brain: New insights on related mechanisms and their translational applications	7
Editorial Board	7
NFKB2 inhibits NRG1 transcription to affect nucleus pulposus cell degeneration and inflammation in intervertebral disc degeneration	7
A role for estrogen in skin ageing and dermal biomechanics	7
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview	7
HRasV12 induces apoptosis, not cellular senescence in mouse skeletal myoblasts	7
Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway	6
Pan-tissue methylation aging clock: Recalibrated and a method to analyze and interpret the selected features	6
The role of NAD+ metabolism in macrophages in age-related macular degeneration	6
Contribution of A-to-I RNA editing, M6A RNA Methylation, and Alternative Splicing to physiological brain aging and neurodegenerative diseases	6
Sex differences in frailty: Comparisons between humans and preclinical models	6
Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells	6
Corrigendum to “Characterization of a natural model of adult mice with different rate of aging” [Mech. Ageing Dev. 222 (2024), 111991]	6
Challenges of infectious diseases in older adults: From immunosenescence and inflammaging through antibiotic resistance to management strategies	6
Exogenous Klotho ameliorates extracellular matrix degradation and angiogenesis in intervertebral disc degeneration via inhibition of the Rac1/PAK1/MMP-2 signaling axis	6
Microbiota-gut-brain axis and Alzheimer’s disease: Implications of the blood-brain barrier as an intervention target	6
A micronutrient mixture with collagen peptides, probiotics, cannabidiol, and diet may reduce aging, and development and progression of age-related alzheimer’s disease, and improve its treatment	6
Lack of activity of the mitochondrial large-conductance calcium-regulated potassium channels in senescent vascular smooth muscle cells.	6
Navigating oligodendrocyte precursor cell aging in brain health	6
α-1 Adrenergic receptor antagonist doxazosin reverses hepatic stellate cells activation via induction of senescence	6
The old guard: Age-related changes in microglia and their consequences	6
Sleep disorders and Alzheimer’s disease pathophysiology: The role of the Glymphatic System. A scoping review	6
The relationship between telomere length and putative markers of vascular ageing: A systematic review and meta-analysis	6
Editorial Board	6
Fall of PARP3 restrains Lgr5+ intestinal stem cells proliferation and mucosal renovation in intestinal aging	5
Antigen presentation capability and AP-1 activation accompany methotrexate-induced colon cancer cell senescence in the context of aberrant β-catenin signaling	5
Editorial Board	5
Unraveling the dual role of ADAM10: Bridging the gap between cancer and Alzheimer’s disease	5
RNA-binding proteins in cellular senescence	5
The impact of opioids on the hallmarks of ageing	5
Understanding Alzheimer’s disease in the context of aging: Findings from applications of stochastic process models to the Health and Retirement Study	5
Current approaches of anti-age related diseases: From molecules up to whole organism	5
Plasma cfDNA abundance as a prognostic biomarker for higher risk of death in geriatric cardiovascular patients	5
Inhibition of Cpt1a alleviates oxidative stress-induced chondrocyte senescence via regulating mitochondrial dysfunction and activating mitophagy	5
Aging: A struggle for beneficial to overcome negative factors made by muscle and bone	5
Effect of age on the vascular proteome in middle cerebral arteries and mesenteric resistance arteries in mice	5
Pathological implication of CaMKII in NF-κB pathway and SASP during cardiomyocytes senescence	5
The damage-independent evolution of ageing by selective destruction	5
Role of cytokines and reactive oxygen species in brain aging	5
Trimethylamine N-oxide (TMAO) drives insulin resistance and cognitive deficiencies in a senescence accelerated mouse model	5
Editorial Board	5
Xenohormesis underlyes the anti-aging and healthy properties of olive polyphenols	5