Bioorganic Chemistry

Article	Citations
Identification and bioactivity evaluation of miliusanes from Miliusa sinensis	282
Editorial Board	131
Editorial Board	108
Development of anti-breast cancer PI3K inhibitors based on 7-azaindole derivatives through scaffold hopping: Design, synthesis and in vitro biological evaluation	104
Engineering an (R)-selective transaminase for asymmetric synthesis of (R)-3-aminobutanol	88
Efficient synthesis of artificial pharmaceutical solid-phase modules for constructing aptamer-drug conjugates	83
Synthesis, structure and acetylcholinesterase inhibition activity of new diarylpyrazoles	82
6-C-Linked trehalose glycolipids signal through Mincle and exhibit potent adjuvant activity	80
Design, expression and biological evaluation of DX-88mut as a novel selective factor XIa inhibitor for antithrombosis	79
2-Trifluoromethyl-2H-chromene ethers: The dual triumph of anti-inflammation and analgesia with minimal ulcer threat	79
Biphenyl substituted lysine derivatives as recognition elements for the matrix metalloproteinases MMP-2 and MMP-9	78
Structural optimization and biological evaluation of ML364 based derivatives as USP2a inhibitors	77
Discovery of neuroprotective Agents: Potent, brain Penetrating, lipoic acid derivatives for the potential treatment of ischemic stroke by regulating oxidative stress and inflammation - a Preliminary s	76
Identification and molecular mechanism of novel 5-alkenyl-2-benzylaminothiazol-4(5H)-one analogs as anti-melanogenic and antioxidant agents	71
Dissection of phospholipases A2 reveals multifaceted peptides targeting cancer cells, Leishmania and bacteria	71
Biotransformations of anthranilic acid and phthalimide to potent antihyperlipidemic alkaloids by the marine-derived fungus Scedosporium apiospermum F41-1	69
Functional characterization and regioselectivity manipulation of two Benzylisoquinoline alkaloids O-methyltransferases from Stephania yunnanensis	69
Synthesis and in vitro leishmanicidal activity of novel N-arylspermidine derivatives	68
seco-Sesquiterpenes and acorane-type sesquiterpenes with antiviral activity from the twigs and leaves of Illicium henryi Diels	68
Corrigendum to “Synthesis and broad-spectrum biocidal effect of novel gemini quaternary ammonium compounds” [Bioorg Chem. 151 (2024) 107646]	68
Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa	66
A near-infrared, colorimetric and ratiometric fluorescent sensor with high sensitivity to hydrogen peroxide and viscosity for solutions detection and imaging living cells	66
Design and synthesis of novel cyclohexanecarboxamides with anticonvulsant effect by activating Nrf2-ARE pathway	63
Structure-based optimization of TEAD inhibitors: Exploring a novel subpocket near Glu347 for the treatment of NF2-mutant cancer	62
Discovery of new covalent inhibitors of monoacylglycerol lipase with the nitrile warhead via SCARdock	62

Repurposing tavaborole to combat resistant bacterial infections through competitive inhibition of KPC-2 and metabolic disruption	61
Biocatalytic one pot three component approach: Facile synthesis, characterization, molecular modelling and hypoglycemic studies of new thiazolidinedione festooned quinoline analogues catalyzed by alka	60
Iron chelation and inhibition of metallopeptidases mediate anti-Trichomonas vaginalis activity by a novel 8-hydroxyquinoline derivative	59
Peptide inhibitors of angiotensin-I converting enzyme based on angiotensin (1–7) with selectivity for the C-terminal domain	58
Mn-doped bimetallic synergistic catalysis boosts for enzymatic phosphorylation of N-Acetylglucosamine/ N-Acetylgalactosamine and their derivatives	58
4-Phenylcoumarin derivatives as new HIV-1 NNRTIs: Design, synthesis, biological activities, and computational studies	58
Novel thiazolopyridine derivatives of diflapolin as dual sEH/FLAP inhibitors with improved solubility	57
Discoidin domain receptor inhibitors as anticancer agents: A systematic review on recent development of DDRs inhibitors, their resistance and structure activity relationship	57
Syntheses and evaluation of acridone derivatives as anticancer agents targeting Kras promoter i-motif structure	56
Ethyl-4-(aryl)-6-methyl-2-(oxo/thio)-3,4-dihydro-1H-pyrimidine-5-carboxylates: Silica supported bismuth(III)triflate catalyzed synthesis and antioxidant activity	56
Design, synthesis, biological evaluation and docking study of some new aryl and heteroaryl thiomannosides as FimH antagonists	55
One pot domino synthesis of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thiones (THTTs) as anti-inflammatory and antinociceptive candidates: A proof from in-vivo to in-vitro and in-silico	54
Rosmarinic acid turned α-syn oligomers into non-toxic species preserving microtubules in Raw 264.7 cells	54
Design, synthesis and biological evaluation of alkynyl-containing maleimide derivatives for the treatment of drug-resistant tuberculosis	54
Dual inhibition of oxidative phosphorylation and glycolysis to enhance cancer therapy	53
Discovery of new 1,2,3,4-tetrahydro-β-carboline derivatives decorated with 3-N-substituted propionyl moiety flexibly bridged-chain as reactive oxygen species inducer for efficient antibacterial treatm	52
Seco-polyprenylated acylphloroglucinols from Hypericum elodeoides induced cell cycle arrest and apoptosis in MCF-7 cells via oxidative DNA damage	52
Synthesis and biological evaluation of new nicotinic acid derivatives as potential anti-inflammatory agents with enhanced gastric safety profile	51
Discovery of linear unnatural peptides as potent mutant isocitrate dehydrogenase 1 inhibitors by Ugi reaction	51
Carvacrol/thymol derivatives as highly selective BuChE inhibitors with anti-inflammatory activities: Discovery and bio-evaluation	50
A chemoenzymatic process for preparation of highly purified dehydroepiandrosterone in high space-time yield	50
Identification of diverse sesquiterpenoids with anti-fibrotic potential from Inula japonica Thunb.	50
Arylidine extensions of 3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-benzenesulfonamide derivatives: Synthesis, computational simulations and biological evaluation as tumor-associated carbonic anhydrase inhi	50
Sulfonamidyl derivatives of sigmacidin: Protein-protein interaction inhibitors targeting bacterial RNA polymerase and sigma factor interaction exhibiting antimicrobial activity against antibiotic-resi	49
A simple ratiometric fluorescent probe for two-photon imaging of carbon monoxide in living cells and zebrafish	49
Casuattimines A–N, fourteen new Lycopodium alkaloids from Lycopodiastrum casuarinoides with Cav3.1 channel inhibitory activity	49
Design, synthesis and biological evaluation of oxadiazole clubbed piperazine derivatives as potential antidepressant agents	48
Design, synthesis, cytotoxic activities, and molecular docking of chalcone hybrids bearing 8-hydroxyquinoline moiety with dual tubulin/EGFR kinase inhibition	48
Discovery of oleanolic acid derivatives that inhibit tau protein phosphorylation and neuroinflammation induced by Aβ25–35 in vitro and in vivo	47
Aromatase inhibitors for the treatment of breast cancer: An overview (2019–2023)	46
Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a mult	46
Discovery of isoliquiritigenin analogues that reverse acute hepatitis by inhibiting macrophage polarization	46
Discovery of diverse sesquiterpenoids from Magnolia grandiflora with cytotoxic activities by inducing cell apoptosis	46
2-Methoxydiol derivatives as new tubulin and HDAC dual-targeting inhibitors, displaying antitumor and antiangiogenic response	45
Tetrahydrobenzothiophene derivatives ameliorate Mia PaCa-2 cell progression and induces apoptosis via inhibiting EGFR2 tyrosine kinase signal	45
Rational development of an ESIPT-based fluorescent probe with large Stokes shift for imaging of hydrogen sulfide in live cells	45
Fatty acid chain modification enhances the serum stability of antimicrobial peptide B1 and activities against Staphylococcus aureus and Klebsiella pneumoniae	44
Novel dual-channel ratiometric fluorescence probe for SO2 detection in food and bioimaging applications based on FRET mechanism	44
Design, synthesis, and biological evaluation of novel FGFR1 PROTACs	44
Structurally diverse phenylpropanoyl phloroglucinol derivatives from Mallotus philippensis and their anti-bacterial activities	44
Dihydroartemisinin suppresses metastatic potential and induces apoptosis in gastric adenocarcinoma: An integrative experimental and computational analysis revealing inhibition of MMP14 and promotion o	43
Targeted isolation and antipyretic mechanisms of 5,7,4′-trimethoxyflavone and p-hydroxybenzoic acid from Mimosa pudica root via cell membrane-coated magnetic carbon spheres integrated with thermal shi	43
Ultra-fast responses NIR fluorescence chemosensor for monitoring HSO3−/SO2 and viscosity as well as its applications in real food samples and living biosystem	43
Biocatalytic conversion of the natural compound bergamottin into novel bioactive epoxy-derivatives using engineered cytochrome P450 BM3	43
A newly synthesized magnetic nanoparticle coated with glycidyl methacrylate monomer and 1,2,4-Triazole: Immobilization of α-Amylase from Bacillus licheniformis for more reuse, stability, and activity	42
Novel natural scaffold as hURAT1 inhibitor identified by 3D-shape-based, docking-based virtual screening approach and biological evaluation	41
Coumarin thiazoles as unique structural skeleton of potential antimicrobial agents	40
Design, synthesis and cytotoxic evaluation of new thieno[2,3-d]pyrimidine analogues as VEGFR-2/AKT dual inhibitors, apoptosis and autophagy inducers	40
Dihydro-β-agarofuran sesquiterpenoids from the root bark of Tripterygium wilfordii and their anti-neuroinflammatory activities	40
Development of fluorinated and methoxylated benzothiazole derivatives as highly potent and selective cannabinoid CB2 receptor ligands	40

Facile green synthesis of zero-valent iron nanoparticles using barberry leaf extract (GnZVI@BLE) for photocatalytic reduction of hexavalent chromium	40
Recent advances on the intervention sites targeting USP7-MDM2-p53 in cancer therapy	39
Rational design of new quinoline-benzimidazole scaffold bearing piperazine acetamide derivatives as antidiabetic agents	39
THP as a sensor for the electrochemical detection of H2O2	38
Development and evaluation of chitosan conjugated Isatin-linked Pyrazole derivative to target anti-inflammatory and anti-fibrotic in ethanol induced liver fibrosis using an in-vivo zebra fish model	37
Issue TOC	37
Design and development of a bright NIR fluorescent probe for selective HSA detection in human blood serum and urine	37
Recent advances in nitrogen-containing heterocyclic compounds as receptor tyrosine kinase inhibitors for the treatment of cancer: Biological activity and structural activity relationship	37
Discovery of novel benzofuro[3,2-b]quinoline derivatives as dual CDK2/Topo I inhibitors	37
Issue TOC	37
Activatable fluorescence molecular imaging and anti-tumor effects investigation of GSH-sensitive BRD4 ligands	37
Polydatin, a derivative of resveratrol, ameliorates busulfan-induced oligozoospermia in mice by inhibiting NF-κB pathway activation and suppressing ferroptosis	37
Issue TOC	37
New diphenyl ethers from a fungus Epicoccum sorghinum L28 and their antifungal activity against phytopathogens	37
Discovery of novel TLR4/MD-2 inhibitors: Receptor structure-based virtual screening studies and anti-inflammatory evaluation	37
Synthesis and anti-proliferative effect of novel 4-Aryl-1, 3-Thiazole-TPP conjugates via mitochondrial uncoupling process	36
Synthesis and evaluation of novel N1-acylated 5-(4-pyridinyl)indazole derivatives as potent and selective haspin inhibitors	36
Meta-substituted piperlongumine derivatives attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis	36
Isomeric 2-isobutylmalate derivatives with anti-pulmonary fibrosis effects from the leaves of Bletilla striata via LC-MS/MS-based molecular networking	36
New pyrrolo[3,4-d] isoxazolidines hybrid with furan as antitumor agents and multi-target enzyme inhibitors: Synthesis and in silico study	36
PD0325901, an ERK inhibitor, attenuates RANKL‐induced osteoclast formation and mitigates cartilage inflammation by inhibiting the NF-κB and MAPK pathways	35
Isatin-pyrimidine hybrid derivatives as enoyl acyl carrier protein reductase (InhA) inhibitors against Mycobacterium tuberculosis	35
15-Hydroxyprostaglandin dehydrogenase inhibitor SW033291 ameliorates hepatic abnormal lipid metabolism, ER stress, and inflammation through PGE2/EP4 in T2DM mice	35
Oxidized tea polyphenol (OTP-3) targets EGFR synergistic nimotuzumab at inhibition of non-small cell lung tumor growth	35
Site-selective sulfation of N-glycans by human GlcNAc-6-O-sulfotransferase 1 (CHST2) and chemoenzymatic synthesis of sulfated antibody glycoforms	35
Design, synthesis, and biological evaluation of novel amidoxime or amidine analogues of some 4-anilino-6,7-dimethoxyquinazolines with a potent EGFR inhibitory effect	34
Pleiotropically activation of azaphilone biosynthesis by overexpressing a pathway-specific transcription factor in marine-derived Aspergillus terreus RA2905	34
Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents	34
Divergent synthesis and elaboration of structure activity relationship for quinoline derivatives as highly selective NTPDase inhibitor	33
Design, synthesis and biological evaluation of antitumor platinum(II) agents conjugated with non-steroidal anti-inflammatory drug species	33
Visualization of nonsmall-cell lung cancer by near-infrared fluorescence imaging with tumor-targeting peptide ABT-510	32
Developing a golgi-targeted fluorescent probe for in situ visualization of the dynamic changes of H2S in cellular stress	32
Novel quinazolinone disulfide analogues as pqs quorum sensing inhibitors against Pseudomonas aeruginosa	32
Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity	32
Hydantoin based dual inhibitors of ALR2 and PARP-1: Design, synthesis, in-vitro and in-vivo evaluation	32
Drugs repurposing: An approach to identify new hits against anticancer drug target TFIIH subunit p8	32
Development of 2′-aminospiro [pyrano[3,2–c]quinoline]-3′-carbonitrile derivatives as non-ATP competitive Src kinase inhibitors that suppress breast cancer cell migration and proliferation	32
Design, synthesis and evaluation of quinolone quaternary ammonium antibacterial agent with killing ability to biofilm	32
Rational design, synthesis, biological evaluation, molecular docking, and molecular dynamics of substituted uracil derivatives as potent anti-cancer agents	31
Design, synthesis, and anti-hepatocellular carcinoma activity evaluation of aryl Lenvatinib derivatives: Exploring potential VEGFR-2 inhibitors	31
Design, synthesis, and biological evaluation of adenosine derivatives targeting DOT1L and HAT as anti-leukemia agents	31
Synthesis, computational simulations and biological evaluation of new dual 5HT1A/5HT7 receptor ligands based on purine-2,6-dione scaffold	31
S-Alkylated sulfonium betulin derivatives: Synthesis, antibacterial activities, and wound healing applications	31
Multifunctional porphyrin-substituted phenylalanine–phenylalanine nanoparticles for diagnostic and therapeutic applications in Alzheimer’s disease	30
Design, synthesis and biological evaluation of a novel non-Gemini analog of UVB1 and crystal structure of its complex with the vitamin D receptor	30
Buckyballs to fight pandemic: Water-soluble fullerene derivatives with pendant carboxylic groups emerge as a new family of promising SARS-CoV-2 inhibitors	30
Volatile oils of Schisandra chinensis (Turcz.) Baill alleviates Parkinson's disease by activating the Nrf2 pathway to positively regulate autophagy and oxidative stress	30
Discovery of thioetomidate derivatives as rapid recovery hypnotics without adrenocortical suppression	30
Design, synthesis and antitumor activity evaluation of novel modified 18β-glycyrrhetinate derivatives as PPARγ agonists	30
Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics	29
Design, synthesis, and structure–activity relationships of xanthine derivatives as broad-spectrum inhibitors of coronavirus replication	29
Synthesis and biological evaluation of novel isatin-phenol hybrids as potential antitumor agents	29
Synthesis of 2-chloropurine ribosides with chiral amino acid amides at C6 and their evaluation as A1 adenosine receptor agonists	29
Identification of novel 3-aryl-1-aminoisoquinolines-based KRASG12C inhibitors: Rational drug design and expedient construction by C H functionalization/annulation	29
Design, synthesis and biological evaluation of new 2,6-difluorinated phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new antimicrotubule agents	29
Probing the Ca2+ mobilizing properties on primary cortical neurons of a new stable cADPR mimic	29
Discovery of evodiamine derivatives as potential lead antifungal agents for the treatment of superficial fungal infections	29
Peniandrastins A–H: Andrastin-type meroterpenoids with immunosuppressive activity from a Penicillium sp.	29
Enantiocomplementary synthesis of β-adrenergic blocker precursors via biocatalytic nitration of phenyl glycidyl ethers	29
CC1007, a small molecular compound, suppresses multiple myeloma via upregulation of Nur77	28
Apigenin analogs as α-glucosidase inhibitors: Molecular docking, biochemical, enzyme kinetic, and an in vivo mouse model study	28
Ginsenoside Rh4 inhibits breast cancer growth through targeting histone deacetylase 2 to regulate immune microenvironment and apoptosis	28
Synthesis and bioevaluation of Scutellarein-Tertramethylpyrazine hybrid molecules for the treatment of ischemic stroke	28
New secondary metabolites with immunosuppressive and BChE inhibitory activities from an endophytic fungus Daldinia sp. TJ403-LS1	28
Discovered cassane diterpenoids from Caesalpinia mimosoides lam. Exhibited anti-renal fibrosis activity via regulating TGF-β1/Smads signaling pathway	28
Tetrodecadazinone, a novel tetrodecamycin-pyridazinone hybrid with anti-liver fibrosis activity from Streptomyces sp. HU051	28
Challenging the anticolorectal cancer capacity of quinoxaline-based scaffold via triazole ligation unveiled new efficient dual VEGFR-2/MAO-B inhibitors	28
Discovery of novel Macrocyclic small molecules Based on 2-Amino-4-thiazolylpyridineas selective EGFR inhibitors with high Blood-Brain barrier penetration for the treatment of glioblastoma	28
Recent developments in mitogen activated protein kinase inhibitors as potential anticancer agents	27
Aurora kinases, emerging critical targets for cancer treatment and related new therapeutic strategies	27
Bioactive Dioxo-Phosphobetaines derived from the reaction of Dichlorodinitrobenzofuroxane with various phosphines	27
In vitro α-amylase and α-glucosidase inhibition study of dihydropyrimidinones synthesized via one-pot Biginelli reaction in the presence of a green catalyst	27
Design, Synthesis, Biocompatibility, molecular docking and molecular dynamics studies of novel Benzo[b]thiophene-2-carbaldehyde derivatives targeting human IgM Fc Domains	27
Unveiling the potential of novel natural product-based MTDLs that integrate cinnamamide scaffold as multifunctional agents for the treatment of Alzheimer's disease	27
The insight into the intermolecular interactions between protamine and insulin lispro	27
Discovery of a novel Coumarin-Dihydroquinoxalone derivative MY-673 as a tubulin polymerization inhibitor capable of inhibiting the ERK pathway with potent anti-gastric cancer activities	27
Metabolism of natural and synthetic bioactive compounds in Cunninghamella fungi and their applications in drug discovery	27
Identification of CH2-linker modified desfluoroquinolone-aminopyrimidine hybrids to combat antibiotic-resistant gram-positive bacteria	27
Discovery of antitubercular potential of trans-3-indoleacrylic acid and its derivatives targeting Mycobacterium tuberculosis: A combined in vitro and in silico investigation	27
Design and synthesis of novel 2-S-alkylated Quinazolinones as dual BRAFV600E and EGFR inhibitors in melanoma: Mechanistic insights from apoptosis and cell cycle modulation	27

Therapeutic applications and molecular mechanisms of TNIK inhibitors: A comprehensive review of current advances	26
Tripeptide linked dispiro cyclotriphosphazene conjugates: Synthesis, molecular docking analysis of compounds binding within cancer cell line receptors and in vitro cytotoxic and genotoxic activities	26
Synthesis and preclinical evaluation of a novel probe [18F]AlF-NOTA-IPB-GPC3P for PET imaging of GPC3 positive tumor	26
Gold nanoparticles-based targeted delivery of rapamycin and Olaparib to breast cancer: An in vitro and in vivo approach	26
Discovery of tetrasubstituted tetrahydropyrimidines as novel inhibitors against influenza a virus	26
Inhibitory effect of liriopesides B in combination with gemcitabine on human pancreatic cancer cells	26
Design, synthesis and evaluation of tetrahydrocarbazole derivatives as potential hypoglycemic agents	26
Cyclometalated Ru(II)-isoquinoline complexes overcome cisplatin resistance of A549/DDP cells by downregulation of Nrf2 via Akt/GSK-3β/Fyn pathway	26
Synthesis and evaluation of pentacyclic triterpenoids conjugates as novel HBV entry inhibitors targeting NTCP receptor	26
Design, synthesis, molecular docking and molecular dynamics studies of novel triazolothiadiazine derivatives containing furan or thiophene rings as anticancer agents	26
Dual site reactivity of indole-3-Schiff bases with S/Se/Cl substituted ketenes for stereoselective C-4 substituted indole-β-lactams, biological evaluations, magic chloro effect and molecular docking s	26
Design, synthesis and biological evaluation of coumarin derivatives as potential BRD4 inhibitors	25
Synthesis of new 2-(thiazol-4-yl)thiazolidin-4-one derivatives as potential anti-mycobacterial agents	25
Investigation of indole functionalized pyrazoles and oxadiazoles as anti-inflammatory agents: Synthesis, in-vivo, in-vitro and in-silico analysis	25
Ugi reaction-assisted assembly of covalent PROTACs against glutathione peroxidase 4	25
RNase H-sensitive multifunctional ASO-based constructs as promising tools for the treatment of multifactorial complex pathologies	25
Artemzhongdianolides A1-A21, antihepatic fibrosis guaiane-type sesquiterpenoid dimers from Artemisia zhongdianensis	25
Potential drug development and therapeutic approaches for clinical intervention in COVID-19	25
Molecular glues targeting GSPT1 in cancers: A potent therapy	25
Advances in synthesis and biological evaluation of CDK2 inhibitors for cancer therapy	25
Promising potential of a 18F-labelled small-molecular radiotracer to evaluate PD-L1 expression in tumors by PET imaging	24
Discovery of 6-amino pyridine clubbed heterocycles as potent dual GSK-3β/CK-1δ inhibitors for the treatment of Alzheimer's disease	24
Issue TOC	24
A bifunctional naphthalimide-based fluorescent probe for imaging lysosomal peroxynitrite and viscosity in living cells and zebrafish	24
New glycoconjugation strategies for Ruthenium(II) arene complexes via phosphane ligands and assessment of their antiproliferative activity	24
Site-directed double monoubiquitination of the repeat domain of the amyloid-forming protein tau impairs self-assembly and coacervation	24
Glioblastoma-specific anticancer activity of newly synthetized 3,5-disubstituted isoxazole and 1,4-disubstituted triazole-linked tyrosol conjugates	24
Synergistic effect of curcumin-Cu and curcumin-Ag nanoparticle loaded niosome: Enhanced antibacterial and anti-biofilm activities	24
Sesquiterpene lactones from Elephantopus scaber exhibit cytotoxic effects on glioma cells by targeting GSTP1	24
Sustainable synthesis of ZnO and FexOy nanoparticles and their nanocomposite ZnFe2O4: Comprehensive characterization and applications in antioxidant activity and antibiotics degradation efficiency	24
Design, synthesis and bioactivity evaluation of thiazolidinedione derivatives as partial agonists targeting PPARγ	24
Development of pteridin-7(8H)-one analogues as highly potent cyclin-dependent kinase 4/6 inhibitors: Synthesis, structure-activity relationship, and biological activity	24
Combined PET and near-infrared fluorescence probe based on lapatinib targeting HER2 for in vivo tumor imaging	24
Development of bifunctional anti-PD-L1 antibody MMAE conjugate with cytotoxicity and immunostimulation	24
Targeting the epigenetic reader “BET” as a therapeutic strategy for cancer	24
Issue TOC	24
Multi-targeting oligopyridiniums: Rational design for biofilm dispersion and bacterial persister eradication	24
Targeted discovery of diterpene compounds ostamycins with anti-influenza a viral activity from a deepsea-derived Streptomyces strain	24
Development of potential anticancer agents and apoptotic inducers based on 4-aryl-4H chromene scaffold: Design, synthesis, biological evaluation and insight on their proliferation inhibition mechanism	24
Brujavanoids A–U, structurally diverse apotirucallane-type triterpenoids from Brucea javanica and their anti-inflammatory effects	23
Identification of new multi-substituted 1H-pyrazolo[3,4-c]pyridin-7(6H)-ones as soluble guanylyl cyclase (sGC) stimulators with vasoprotective and anti-inflammatory activities	23
Development of new 1, 3-dihydroxyacridone derivatives as Akt pathway inhibitors in skeletal muscle cells	23
Novel N or N modified α-carboline analogues as potential ligands in Alzheimer's disease therapy: Synthesis and neurobiological activity evaluation	23
The AMPA receptor biophysical gating properties and binding site: Focus on novel curcumin-based diazepines as non-competitive antagonists	23
New anti-inflammatory and non-cytotoxic metabolites of methylstenbolone obtained by microbial transformation	23
Corrigendum to “Design and synthesis of novel isatin-based derivatives targeting cell cycle checkpoint pathways as potential anticancer agents” [Bioorg. Chem. 105 (2020) 104366]	23
Discovery of a novel OGT inhibitor through high-throughput screening based on Homogeneous Time-Resolved Fluorescence (HTRF)	23
Inonotsutriol E from Inonotus obliquus exhibits promising anti breast cancer activity via regulating the JAK2/STAT3 signaling pathway	23
Protein coupled thionine acetate probed silica nanoparticles: An integrated laser-assisted therapeutic approach for treating cancer	23
Introduction of a β-leucine residue instead of leucine9 and glycine10 residues in Temporin L for improved cell selectivity, stability and activity against planktonic and biofilm of methicillin resista	23
Interactions of isoorientin and its Semi-synthetic analogs with human serum albumin	23
Benzoxazole-appended piperidine derivatives as novel anticancer candidates against breast cancer	23
Photosensitizer-based small molecule theranostic agents for tumor-targeted monitoring and phototherapy	23
Curcumol derivatives exhibit ameliorating effects on lipopolysaccharide-induced acute lung injury: Synthesis, biological evaluation, structure–activity relationship and action mechanism	23
Design and evaluation of novel inhibitors for the treatment of clear cell renal cell carcinoma	23
1H NMR-guided isolation of hasubanan alkaloids from the alkaloidal extract of Stephania longa	23
Effective α-glycosidase inhibitors based on polyphenolic benzothiazole heterocycles	23
Anti-proliferative tirucallane triterpenoids from gum resin of Boswellia sacra	23
Tryptanthrins as multi-bioactive agents: discovery, diversity distribution and synthesis	23
Green synthesis and anti-tumor efficacy via inducing pyroptosis of novel 1H-benzo[e]indole-2(3H)-one spirocyclic derivatives	23
Discovery of ent-kaurane diterpenoid glucosides as potent analgesics from the leaves of Pieris formosa	23
Development and biological evaluation of 68Ga-labeled peptides for potential application in HER2-positive colorectal cancer	23
Enzyme engineering improves catalytic efficiency and enantioselectivity of hydroxynitrile lyase for promiscuous retro-nitroaldolase activity	23
7S,15R-Stereoisomer of phenylethylamino derivative of colchicine exhibits potent in-vitro and in-vivo anti-cancer activity against prostate Cancer: Assessing the impact of stereochemistry on biologica	22
Design, synthesis and evaluation of quinazoline derivatives as Gαq/11 proteins inhibitors against uveal melanoma	22
Membrane mechanism of temporin-1CEc, an antimicrobial peptide isolated from the skin secretions of Rana chensinensis, and its systemic analogs	22
Double-edged Swords: Diaryl pyrazoline thiazolidinediones synchronously targeting cancer epigenetics and angiogenesis	22
Novel piperazine urea derivatives as highly potent transient receptor potential vanilloid 1 (TRPV1) antagonists	22
An overall framework for the E. coli γ-glutamyltransferase-catalyzed transpeptidation reactions	22
The first peptide derivatives of dioxybiphenyl-bridged spiro cyclotriphosphazenes: In vitro cytotoxicity activities and DNA damage studies	22
1,2,3-Triazolo[4,5-b]aminoquinolines: Design, synthesis, structure, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity, and molecular docking of novel modified tacrines	22
Mitochondrial targeted modification and anticancer mechanism of natural product ergosterol peroxide	22
New ε-N-thioglutaryl-lysine derivatives as SIRT5 inhibitors: Chemical synthesis, kinetic and crystallographic studies	22
Editorial Board	22
Synthesis, structural, multitargeted molecular docking analysis of anti-cancer, anti-tubercular, DNA interactions of benzotriazole based macrocyclic ligand	22
(±)-Heterocageflavone, anti-inflammatory isoprenylated flavonoids with a tricyclo[5.3.1.03,8]undecane moiety from Artocarpus heterophyllus	22
Combined active pocket and hinge region engineering to develop an NADPH-dependent phenylglycine dehydrogenase	22
Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars	22
Synthesis of 3-aryl-4-(N-aryl)aminocoumarins via photoredox arylation and the evaluation of their biological activity	22
Radiopharmaceuticals in Nasopharyngeal Cancer	22
Acquiring stereospecific new pseudosugars: Obtaining rac-decahydro-1,4-epoxynaphthalene-2,3,5,6,7,8-hexaols from the Diels-Alder reaction and investigating their biological effects	22
Design, synthesis and biological evaluation of glycolamide, glycinamide, and β-amino carbonyl 1,2,4-triazole derivatives as DPP-4 inhibitors	22
Selective MOR activity of DAPEA and Endomorphin-2 analogues containing a (R)-γ-Freidinger lactam in position two	22
Functionalized magnetic particles coupled with LC-MS strategy facilitated discovery of trace thioalkaloids with potent immunosuppressive activity	22
Resorcylic acid lactones from a Podospora sp. that induce apoptosis in activated T cells through MAPKs/AKT pathway	22
Synthesis, X-ray, antioxidant, in-vitro biological & in-silico docking studies of novel organoselenides: Promising colorectal cancer inhibitors	22
Development of novel cyanopyridines as PIM-1 kinase inhibitors with potent anti-prostate cancer activity: Synthesis, biological evaluation, nanoparticles formulation and molecular dynamics simulation	22
Discovery of ARS-1620 analogs as KRas G12C inhibitors with high in vivo antitumor activity	22
Gracillin induces mitochondria-mediated apoptosis on pancreatic ductal adenocarcinoma through disruption of redox homeostasis via inhibiting NRF2/HO-1 antioxidant axis	21
Synthesis of novel calcium channel blockers with ACE2 inhibition and dual antihypertensive/anti-inflammatory effects: A possible therapeutic tool for COVID-19	21
Novel steroidal oximes as antiproliferative agents: Design, synthesis and biological activity evaluation	21
Chelerythrine may bind to KRAS mRNA G-quadruplex in the cisplatin-resistant non-small cell lung cancer cells	21
Editorial Board	21
Lysosome-targeted NIR fluorescent probe for assessment of ferroptosis-mediated drug-induced liver injury via viscosity fluctuations	21
Novel 1,3,4-thiadiazole/oxadiazole-linked honokiol derivatives suppress cancer via inducing PI3K/Akt/mTOR-dependent autophagy	21