Bioorganic Chemistry

Article	Citations
Water-soluble pillar[5]arene sulfo-derivatives self-assemble into biocompatible nanosystems to stabilize therapeutic proteins	218
(±)-Caryopterisines A and B, dimeric monoterpene alkaloids with unprecedented 6/5/5/5/6 pentacyclic rings scaffold from Caryopteris glutinosa	157
FPR2-based anti-inflammatory and anti-lipogenesis activities of novel meroterpenoid dimers from Ganoderma	93
Recent advancements in the quest of benzazoles as anti-Mycobacterium tuberculosis agents	90
Design, synthesis, and biological evaluation of novel thiourea derivatives as small molecule inhibitors for prostate specific membrane antigen	86
Exploration of triazole derivatives, SAR profiles, and clinical pipeline against Mycobacterium tuberculosis	84
Design, synthesis, and biological evaluation of novel FGFR1 PROTACs	84
Synthesis and biological evaluation of 4-((3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)quinoline derivatives as novel potential transforming growth factor-β type 1 receptor inhibitors for hepatoc	82
Heterologous expression of calcium-independent mesophilic α-amylase from Priestia megaterium: Immobilization on genipin-modified multi-walled carbon nanotubes and silica supports to enhance thermostab	75
Triazole derivatives inhibit the VOR complex-mediated nuclear transport of extracellular particles: Potential application in cancer and HIV-1 infection	71
Development and therapeutic potential of DNA-dependent protein kinase inhibitors	70
Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition	66
Impact of sulfur substitution on biotin binding affinity to streptavidin	66
Development of new chiral 1,2,4-triazole-3-thiones and 1,3,4-thiadiazoles with promising in vivo anticonvulsant activity targeting GABAergic system and voltage-gated sodium channels (VGSCs)	65
Aromatase inhibitors for the treatment of breast cancer: An overview (2019–2023)	63
Design and synthesis of new 2-oxoquinoxalinyl-1,2,4-triazoles as antitumor VEGFR-2 inhibitors	61
Mahanimbine isolated from Murraya koenigii inhibits P-glycoprotein involved in lung cancer chemoresistance	61
Synthesis of indole-based-thiadiazole derivatives as a potent inhibitor of α-glucosidase enzyme along with in silico study	60
Structural characteristics of a low molecular weight velvet antler protein and the anti-tumor activity on S180 tumor-bearing mice	60
Discovery of novel dihydropyrazole-stilbene derivatives for ameliorating heart failure through modulation of p38/NF-κB signaling pathway	60
SAR study of oxidative DIMs analogs targeting the Nur77-mediated apoptotic pathway of cancer cells	59
Multi-component forms of the 2nd generation H1 receptor antagonist drug, Bilastine and its enhanced physicochemical characteristics	59
Advancements in folate receptor targeting for anti-cancer therapy: A small molecule-drug conjugate approach	57
Recent developments of P-glycoprotein inhibitors and its structure–activity relationship (SAR) studies	57
Cholinesterase inhibitors assessment of aporphine alkaloids from Annona crassiflora and molecular docking studies	56

Novel heptafluoroisopropyl N-phenylpyrazole aryl amides containing cyanoalkyl groups: Design, synthesis, insecticidal activity, docking studies and theoretical calculations	55
Discovery of new small molecule inhibitors of the BPTF bromodomain	54
Nematocidal alkaloids from the roots of Stemona mairei (H.Lév.)K.Krause and identification of their pharmacophoric moiety	54
Editorial Board	52
Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3α (GSK-3α): Development and impact on temozolomide treatment of glioblastoma cells	52
Inhibition of staphylococcal nuclease by benzimidazole-based Ligand: Implications in DNA-Mediated entrapment and uptake of MRSA by Macrophage-like cells	52
Inhibitors of bacterial RNA polymerase transcription complex	52
Discovery of novel selective phosphodiesterase‑1 inhibitors for the treatment of acute myelogenous leukemia	52
Monoamine oxidase A and B inhibitory activities of 3,5-diphenyl-1,2,4-triazole substituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives	52
An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94	51
Hybridization of amantadine with gardenamide A enhances NMDA antagonism and in vivo anti-PD effects	51
N-(3-cyano-1H-indol-5-yl)isonicotinamide and N-(3-cyano-1H-indol-5-yl)-1H-benzo[d]imidazole-5-carboxamide derivatives: Novel amide-based xanthine oxidase inhibitors	50
Identification of (E)-1-((1H-indol-3-yl)methylene)-4-substitute-thiosemicarbazones as potential anti-hepatic fibrosis agents	49
Discovery of N-arylcinnamamides as novel erythroblast enucleation inducers	49
Design, synthesis and biological evaluation of hybrid of ubenimex-fluorouracil for hepatocellular carcinoma therapy	48
Design, synthesis and biological evaluation of alkynyl-containing maleimide derivatives for the treatment of drug-resistant tuberculosis	48
Light and hydrogen peroxide dual-responsive DNA interstrand crosslink precursors with potent cytotoxicity	48
Synthesis of N-methylpyridine-chlorofuranformamide analogs as novel OPG up-regulators and inhibitors of RANKL-induced osteoclastogenesis	48
Receptor mapping using methoxy phenyl piperazine derivative: Preclinical PET imaging	47
Advanced high-affinity glycoconjugate ligands of galectins	47
Isolation and target identification of anti-renal fibrosis compounds from Cordyceps militaris	47
6-C-Linked trehalose glycolipids signal through Mincle and exhibit potent adjuvant activity	46
Glycomimetic inhibitors of tandem-repeat galectins: Simple and efficient	46
Thioether-based novel transition metal complexes: Synthesis, DNA interaction, in vitro biological assay, DFT calculations, and molecular docking studies	46
Issue TOC	45
A chemoenzymatic process for preparation of highly purified dehydroepiandrosterone in high space-time yield	45
Onychiol B attenuates lipopolysaccharide-induced inflammation via MAPK/NF-κB pathways and acute lung injury in vivo	45
Buffalo colostrum peptide mitigates Parkinson's disease pathophysiology through Cullin-3 inhibition	45
seco-Sesquiterpenes and acorane-type sesquiterpenes with antiviral activity from the twigs and leaves of Illicium henryi Diels	44
Design, synthesis, biological evaluation and docking study of some new aryl and heteroaryl thiomannosides as FimH antagonists	44
Synthesis of new phenoxymethylcoumarin clubbed 4-arylthiazolylhydrazines as α-glucosidase inhibitors and their kinetics and molecular docking studies	44
3-Imino derivative-sulfahydantoins: Synthesis, in vitro antibacterial and cytotoxic activities and their DNA interactions	43
Proteasome activation: A novel strategy for targeting undruggable intrinsically disordered proteins	43
Peptide inhibitors of angiotensin-I converting enzyme based on angiotensin (1–7) with selectivity for the C-terminal domain	43
Guided rational design with scaffold hopping leading to novel histamine H3 receptor ligands	43
A novel NIR fluorescent probe inhibits melanoma progression through apoptosis and ERK/DRP1-mediated mitochondrial fission	43
The C-terminal segment of Leishmania major HslU: Toward potential inhibitors of LmHslVU activity	42
Iron chelation and inhibition of metallopeptidases mediate anti-Trichomonas vaginalis activity by a novel 8-hydroxyquinoline derivative	42
New enantiomeric lignans and new meroterpenoids with nitric oxide release inhibitory activity from Piper puberulum	42
pH-promoted O-α-glucosylation of flavonoids using an engineered α-glucosidase mutant	42
Issue TOC	41
4-Chlorophenylthioacetone-derived thiosemicarbazones as potent antitrypanosomal drug candidates: Investigations on the mode of action	41
Efficient synthesis of artificial pharmaceutical solid-phase modules for constructing aptamer-drug conjugates	41
Natural product protulactone A: Total synthesis from D-galactose, X-ray analysis and biological evaluation	41
Editorial Board	41
Study of G protein-coupled receptors dimerization: From bivalent ligands to drug-like small molecules	41
Nanotechnology applications for treatment of hepatic infections via modulating Hepatic histopathological and DNA alterations	41
Protecting-group free synthesis of glycoconjugates displaying dual fungicidal and plant defense-eliciting activities	41
Discovery of novel 1H-benzo[d]imidazole-4,7-dione based transglutaminase 2 inhibitors as p53 stabilizing anticancer agents in renal cell carcinoma	40
Identification of diverse sesquiterpenoids with anti-fibrotic potential from Inula japonica Thunb.	40

Incorporation of a FRET pair within a phosphonate diester	40
A comprehensive review of small molecules targeting PI3K pathway: Exploring the structural development for the treatment of breast cancer	40
Design, synthesis and biological evaluation of acyl hydrazones-based derivatives as RXRα-targeted anti-mitotic agents	39
A possible covalent xanthine oxidase inhibitor TS10: Inhibition mechanism, metabolites identification and PDPK assessment	39
SKLB-14b, a novel oral microtubule-destabilizing agent based on hydroxamic acid with potent anti-tumor and anti-multidrug resistance activities	39
Development of fluorescent dual-FRET probe for simultaneous detection of caspase-8 and caspase-9 activities and their relative quantification	39
Probing naphthalene diimide and 3-hydroxypropylphosphate as end-conjugating moieties for improved thrombin binding aptamers: Structural and biological effects	38
Synthesis and biological evaluation of novel 3-(5-substituted-1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with a dual affinity for serotonin 5-HT1A receptor and SERT	38
Synthesis of mitochondria-targeted ferulic acid amide derivatives with antioxidant, anti-inflammatory activities and inducing mitophagy	38
Euryfuranyl compounds from edible species of cuttlefish as potential anti-inflammatory leads attenuating NF-κB signaling cascade in lipopolysaccharide-activated macrophages	38
Design, expression and biological evaluation of DX-88mut as a novel selective factor XIa inhibitor for antithrombosis	37
Mn-doped bimetallic synergistic catalysis boosts for enzymatic phosphorylation of N-Acetylglucosamine/ N-Acetylgalactosamine and their derivatives	37
Isolation, identification, and activity evaluation of antioxidant components from Inula viscosa: A bioguided approach	37
Optimization of a cell surface vimentin binding peptoid to extract antagonist effect on lung cancer cells	36
Development of novel androgen receptor antagonists based on the structure of darolutamide	36
Identification of selective ligands targeting two GPCRs by receptor-affinity chromatography coupled with high-throughput sequencing techniques	36
Discovery of stylissatin A analogs exhibiting potent nitric oxide inhibition	36
Discovery of linear unnatural peptides as potent mutant isocitrate dehydrogenase 1 inhibitors by Ugi reaction	36
Issue TOC	36
Novel thiazolopyridine derivatives of diflapolin as dual sEH/FLAP inhibitors with improved solubility	36
Antibiotic resistance and drug modification: Synthesis, characterization and bioactivity of newly modified potent ciprofloxacin derivatives	35
Disaccharide-polyethylenimine organic nanoparticles as non-toxic in vitro gene transporters and their anticancer potential	35
Minor immunosuppressive spiroorthoester group-containing pregnane glycosides from the root barks of Periploca sepium	35
Design, synthesis and biological evaluation of novel pleuromutilin derivatives possessing 4-aminothiophenol linker as promising antibacterial agents	35
Procerolides A-B from Microcionidae marine sponge Clathria procera: Anti-inflammatory macrocylic lactones with selective cyclooxygenase-2 attenuation properties	35
Synthesis of 6-epi-tuberiferin and the biological activities of tuberiferin, dehydrobrabrachylaenolide, 6-epi-tuberiferin, and their synthetic intermediates	35
Issue TOC	34
Design, synthesis, and cytotoxic activity of novel 2H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidine derivatives	34
Novel antimicrobial peptide DvAMP serves as a promising antifungal agent against Cryptococcus neoformans	34
Synthesis, biological evaluation, pharmacokinetic studies and molecular docking of 4′′′-acetyl-delicaflavone as antitumor agents	34
Synthesis and biological evaluation of novel withangulatin A derivatives as potential anticancer agents	34
Synthesis and antitubercular activity of novel 4-arylalkyl substituted thio-, oxy- and sulfoxy-quinoline analogues targeting the cytochrome bc1 complex	34
Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a mult	34
Editorial Board	34
Synthesis, bio-physical and anti-leishmanial studies of some novel indolo[3,2-a]phenanthridine derivatives	33
Design and synthesis of β-carboline and combretastatin derivatives as anti-neutrophilic inflammatory agents	32
Tubulin degradation: Principles, agents, and applications	32
Bioisosteric ferrocenyl 1,3-thiazolidine-4-carboxylic acid derivatives: In vitro antiproliferative and antimicrobial evaluations	32
Discovery of diverse sesquiterpenoids from Magnolia grandiflora with cytotoxic activities by inducing cell apoptosis	32
Unsaturated lipids modulating the interaction of the antileishmanial isolinderanolide E with models of cellular membranes	31
Discovery of aminothiazole derivatives as novel human enterovirus A71 capsid protein inhibitors	31
The discovery of novel sanjuanolide derivatives as chemotherapeutic agents targeting castration-resistant prostate cancer	31
Design, synthesis and biological evaluation of selective histone deacetylase 6 (HDAC6) inhibitors bearing benzoindazole or pyrazoloindazole scaffold as surface recognition motif	31
Issue TOC	31
New benzothienopyran and benzothienopyranopyrimidine derivatives as topoisomerase I inhibitors: Design, synthesis, anticancer screening, apoptosis induction and molecular modeling studies	31
Discovery of pyrrolo[1,2-a]quinoxalin-4(5H)-one derivatives as novel non-covalent Bruton’s tyrosine kinase (BTK) inhibitors	31
Discovery of hepatoprotective activity components from Thymus quinquecostatus celak. by molecular networking, biological evaluation and molecular dynamics studies	30
Efficient biosynthesis of Vibegron intermediate using a novel carbonyl reductase based on molecular modification of hydrogen bonding network regulation	30
Issue TOC	30
Discovery of novel benzofuro[3,2-b]quinoline derivatives as dual CDK2/Topo I inhibitors	30
Small organic molecules accelerate the expansion of regulatory T cells	30
EZH2 serves as a promising therapeutic target for fibrosis	30
Unleashing the potential of natural biological peptide Macropin: Hydrocarbon stapling for effective breast cancer treatment	30
Arylacryl amides: Design, synthesis and the protection against cisplatin-induced acute kidney injury via TLR4/STING/NF-κB pathway	29
A novel benzothiophene incorporated Schiff base acting as a “turn-on” sensor for the selective detection of Serine in organic medium	29
Genome-directed discovery of antiproliferative bafilomycins from a deepsea-derived Streptomyces samsunensis	29
Novel 4-Amino-Quinazoline moieties ligated Platinum(IV) prodrugs overcome cisplatin resistance in EGFRWT human lung cancer	29
Discovery of berberine analogs as potent and highly selective p300/CBP HAT inhibitors	29
B13, a well-tolerated inhibitor of hedgehog pathway, exhibited potent anti-tumor effects against colorectal carcinoma in vitro and in vivo	29
Regioselectivity in inhibition of peptide deformylase from Haemophilus influenzae by 4- vs 5-azaindole hydroxamic acid derivatives: Biochemical, structural and antimicrobial studies	29
Discovery of isoliquiritigenin analogues that reverse acute hepatitis by inhibiting macrophage polarization	28
Development of fluorinated and methoxylated benzothiazole derivatives as highly potent and selective cannabinoid CB2 receptor ligands	28
Energy metabolism as a target for cyclobenzaprine: A drug candidate against Visceral Leishmaniasis	28
Novel 4-phenoxypyridine derivatives bearing imidazole-4-carboxamide and 1,2,4-triazole-3-carboxamide moieties: Design, synthesis and biological evaluation as potent antitumor agents	28
Biological activity and ADME/Tox prediction of some 2-substituted benzoxazole derivatives	28
Novel bisubstrate uridine-peptide analogues bearing a pyrophosphate bioisostere as inhibitors of human O-GlcNAc transferase	28
Dissection of phospholipases A2 reveals multifaceted peptides targeting cancer cells, Leishmania and bacteria	28
Synthesis and structure–activity relationships of ticlopidine derivatives and analogs as inhibitors of ectonucleotidase CD39	28
Discovery of a novel GRPR antagonist for protection against cisplatin-induced acute kidney injury	28
Lipopeptides production by a newly Halomonas venusta strain: Characterization and biotechnological properties	28
1,2-Isoselenazol-3(2H)-one derivatives as NDM-1 inhibitors displaying synergistic antimicrobial effects with meropenem on NDM-1 producing clinical isolates	28
Synthesis, structure and acetylcholinesterase inhibition activity of new diarylpyrazoles	28
Scaffold overlay of flavonoid-inspired molecules: Discovery of 2,3-diaryl-pyridopyrimidin-4-imine/ones as dual hTopo-II and tubulin targeting anticancer agents	28
Design, synthesis, modelling studies and biological evaluation of 1,3,4-oxadiazole derivatives as potent anticancer agents targeting thymidine phosphorylase enzyme	27
Biphenyl substituted lysine derivatives as recognition elements for the matrix metalloproteinases MMP-2 and MMP-9	27
Synthesis and biological evaluation of new nicotinate derivatives as potential anti-inflammatory agents targeting COX-2 enzyme	27
Structural modification of natural axinelline A: Achieving reduced colitis side effects through balanced COX inhibition	27
Discovery of novel TLR4/MD-2 inhibitors: Receptor structure-based virtual screening studies and anti-inflammatory evaluation	27
A NMR study of binding the metabolite of SN38 derivatives to a model nicked DNA decamer mimicking target of Topo I inhibitors	27
Coumarins-lipophilic cations conjugates: Efficient mitocans targeting carbonic anhydrases	26

Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies	26
Membrane interactions in Alzheimer’s disease treatment strategies with multitarget molecules	26
Rational development of an ESIPT-based fluorescent probe with large Stokes shift for imaging of hydrogen sulfide in live cells	26
Design, synthesis and evaluation of EZH2-based PROTACs targeting PRC2 complex in lymphoma	26
Discovery of a new class of potent pyrrolo[3,4-c]quinoline-1,3-diones based inhibitors of human dihydroorotate dehydrogenase: Synthesis, pharmacological and toxicological evaluation	26
Carbazole-based mitochondria-targeted fluorescent probes for in vivo viscosity and cyanide detection in cells and zebrafish	26
Synthesis and in vitro cytotoxic activity of dye-linker-macrocycle conjugates with variable linker length and components	26
Exploration and structure–activity relationship research of benzenesulfonamide derivatives as potent TRPV4 inhibitors for treating acute lung injury	26
Counterion influence on near-infrared-II heptamethine cyanine salts for photothermal therapy	25
Nitroreductase-induced bioorthogonal ligation for prodrug activation: A traceless strategy for cancer-specific imaging and therapy	25
Unveiling a new strategy for PDIA1 inhibition: Integration of activity-based probes profiling and targeted degradation	25
Selective activation of prodrugs in breast cancer using metabolic glycoengineering and the tetrazine ligation bioorthogonal reaction	25
Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease	25
Discovery of a highly selective fluorescent probe for hydrogen peroxide and its biocompatibility evaluation and bioimaging applications in cells and zebrafish	25
Inhibition of TGF-β1/Smad3 signaling by compound 5aa: A potential treatment for idiopathic pulmonary fibrosis	25
Water-soluble alkaloids isolated from Portulaca oleracea L.	25
Synthesis and characterization of organoselenium based BODIPY and its application in living cells	25
Unlocking the potential of higher-molecular-weight 5-HT7R ligands: Synthesis, affinity, and ADMET examination	24
A new strategy for the treatment of Parkinson’s disease: Discovery and bio-evaluation of the first central-targeting tyrosinase inhibitor	24
Structurally various p-terphenyls with neuraminidase inhibitory from a sponge derived fungus Aspergillus sp. SCSIO41315	24
Rosmarinic acid turned α-syn oligomers into non-toxic species preserving microtubules in Raw 264.7 cells	24
Screening and characterization of a β-xylosidase from Bifidobacterium breve K-110 and its application in the biotransformation of the total flavonoids of epimedium to icariin with α-l-rhamnosidase	24
Structural optimization and biological evaluation of ML364 based derivatives as USP2a inhibitors	24
Design, synthesis, and biological evaluation of carbonyl-hydrazine-1-carboxamide derivatives as anti-hepatic fibrosis agents targeting Nur77	24
Synthesis of novel oxazol-5-one derivatives containing chiral trifluoromethyl and isoxazole moieties as potent antitumor agents and the mechanism investigation	24
Carbazole alkaloids with potential cytotoxic activities targeted on PCK2 protein from Murraya microphylla	24
Novel 131-iodine labeled and ultrasound-responsive nitric oxide and reactive oxygen species controlled released nanoplatform for synergistic sonodynamic/nitric oxide/chemodynamic/radionuclide therapy	24
Design and synthesis of 9-phenanthranilamide derivatives and the study of anti-inflammatory, antioxidant and neuroprotective activities	24
Potent antiplasmodial alkaloids from the rhizobacterium Pantoea agglomerans as hemozoin modulators	23
Synthesis and biological evaluation of heterocyclic ring-fused dammarane-type ginsenoside derivatives as potential anti-tumor agents	23
Expansion of targeted degradation by Gilteritinib-Warheaded PROTACs to ALK fusion proteins	23
Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: Anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies	23
Design, synthesis and biological evaluation of 7–(5–((substituted – amino)-methyl)-thiophen–2–yl)-spiro-[chroman–2,4′–piperidin]–4–one hydrochloride analogues as anticancer agents	23
Heteryunine A, an amidated tryptophan-catechin-spiroketal hybrid with antifibrotic activity from Heterosmilax yunnanensis	23
Design, synthesis and anticancer evaluation of novel oncolytic peptide-chlorambucil conjugates	23
Design, synthesis and biological evaluation of novel bischalcone derivatives as potential anticancer agents	23
Exploring the potential intracellular targets of vascular normalization based on active candidates	23
Transforming iodoquinol into broad spectrum anti-tumor leads: Repurposing to modulate redox homeostasis	23
Astraoleanosides E–P, oleanane-type triterpenoid saponins from the aerial parts of Astragalus membranaceus Bunge and their β-glucuronidase inhibitory activity	23
Telomerase activators from 20(27)-octanor-cycloastragenol via biotransformation by the fungal endophytes	23
Design, synthesis and antitumor activities of phthalazinone derivatives as PARP-1 inhibitors and PARP-1/HDAC-1 inhibitors	22
Novel mandelic acid derivatives containing piperazinyls as potential candidate fungicides against Monilinia fructicola: Design, synthesis and mechanism study	22
Design, synthesis, and biological activities of arecoline derivatives containing 1,3,4-oxadiazole structure	22
Acovenosigenin A β-glucoside mediates JAK2-STAT3 signaling pathway by targeting GP130 in A549 and H460 cells based on integrative analysis of transcriptome and proteome and biological verification	22
Discovery and evolution of berberine analogues as anti-Helicobacter pylori agents with multi-target mechanisms	22
Antiproliferative activity, enzymatic inhibition and apoptosis-promoting effects of benzoxazole-based hybrids on human breast cancer cells	22
Design, synthesis, biological activity evaluation and structure-activity relationships of new steroidal aromatase inhibitors. The case of C-ring and 7β substituted steroids	22
Structure-activity relationship studies of dipeptide-based hepsin inhibitors with Arg bioisosteres	22
Metal-free internal nucleophile-triggered domino route for synthesis of fused quinoxaline [1,4]-diazepine hybrids and the evaluation of their DNA binding properties	22
Cephalostatins and ritterazines: Distinctive dimeric marine-derived steroidal pyrazine alkaloids with intriguing anticancer activities	22
Tetrahydropyridine appended 8-aminoquinoline derivatives: Design, synthesis, in silico, and in vitro antimalarial studies	22
Identification of diterpenoids from Salvia castanea Diels f. tomentosa Stib and their antitumor activities	22
THP as a sensor for the electrochemical detection of H2O2	22
Design, synthesis and in silico insights of new 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives with potent anticancer and multi-kinase inhibitory activities	22
Synthesis, in vitro anticancer activity and in silico studies of certain isoxazole-based carboxamides, ureates, and hydrazones as potential inhibitors of VEGFR2	22
Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway	22
Design, synthesis, molecular docking and in silico ADMET profile of pyrano[2,3-d]pyrimidine derivatives as antimicrobial and anticancer agents	22
Saponins from Dolichos lablab seeds with anti-inflammatory activity	22
The utility of Streptococcus mutans undecaprenol kinase for the chemoenzymatic synthesis of diverse non-natural isoprenoids	22
Cedrol in ginger (Zingiber officinale) as a promising hair growth drug: The effects of oral and external administration on hair regeneration and its mechanism	22
Synthesis and evaluation of the anti-inflammatory activity of novel 8-quinolinesulfonamide derivatives as TLR4/MD-2 inhibitors with efficacy in adjuvant-induced arthritis	22
New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer	22
Synthetic access to syn-functionalised chiral hydroxy pyrrolidines and pyrrolidones: Evaluation of α-glucosidase inhibition activity, docking studies and pharmacokinetics prediction	22
X-ray crystallography study and optimization of novel benzothiophene analogs as potent selective estrogen receptor covalent antagonists (SERCAs) with improved potency and safety profiles	22
Combining photo-redox and enzyme catalysis for the synthesis of 4H-pyrimido[2,1-b] benzothiazole derivatives in one pot	22
Unusual polyoxygenated casbane diterpenoids from the South China Sea soft coral Sinularia erecta	21
Synthesis and biological evaluation of 1-phenyl-4,6-dihydrobenzo[b]pyrazolo[3,4-d]azepin-5(1H)-one/thiones as anticancer agents	21
Design, synthesis, and biological evaluation of hydroxamic acid-substituted 2,4-diaryl aminopyrimidines as potent EGFRT790M/L858R inhibitors for the treatment of NSCLC	21
Synthesis and anticancer evaluation of 6-azacyclonol-2,4,6-trimethylpyridin-3-ol derivatives: M3 muscarinic acetylcholine receptor-mediated anticancer activity of a cyclohexyl derivative in androgen-r	21
Casuattimines A–N, fourteen new Lycopodium alkaloids from Lycopodiastrum casuarinoides with Cav3.1 channel inhibitory activity	21
Novel indazole derivatives as potent apoptotic antiproliferative agents by multi-targeted mechanism: Synthesis and biological evaluation	21
Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity	21
Identification of new lead molecules against anticancer drug target TFIIH subunit P8 using biophysical and molecular docking studies	21
Self-assembled dehydropeptide nanocarrier as a delivery system for antitumor drug temozolomide	21
Synthesis, biological evaluation, and molecular docking study of some new rohitukine analogs as protein tyrosine phosphatase 1B inhibitors	21
Discovery of new pyrimido[5,4-c]quinolines as potential antiproliferative agents with multitarget actions: Rapid synthesis, docking, and ADME studies	21
Design, synthesis, cytotoxic activities, and molecular docking of chalcone hybrids bearing 8-hydroxyquinoline moiety with dual tubulin/EGFR kinase inhibition	21
Structural simplification and bioisostere principle lead to Bis-benzodioxole-fibrate derivatives as potential hypolipidemic and hepatoprotective agents	21
Design, synthesis, and evaluation of proliferation inhibitory activity of novel L-shaped ortho-quinone analogs as anticancer agents	20
The cryptic metabolites and anti-phytopathogenic activities from Nigrospora lacticolonia and Penicillium rubens uncovered by the synergism with host Paris polyphylla, monoculture, and co-culture	20
Diversity-oriented synthesis through gamma radiolysis: Preparation of unusual ecdysteroid derivatives activating Akt and AMPK in skeletal muscle cells	20
Discovery of new chalone adamantyl arotinoids having RXRα-modulating and anticancer activities	20
Novel metronidazole-derived three-component hybrids as promising broad-spectrum agents to combat oppressive bacterial resistance	20
Novel dual-target μ‑opioid and TRPV1 ligands as potential pharmacotherapeutics for pain management	20
Biotransformations of anthranilic acid and phthalimide to potent antihyperlipidemic alkaloids by the marine-derived fungus Scedosporium apiospermum F41-1	20
Antimicrobial macrozones interact with biological macromolecules via two-site binding mode of action: Fluorimetric, NMR and docking studies	20
Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new anti-vitiligo compounds	20
Synthesis and evaluation of novel fluorinated hematoporphyrin ether derivatives for photodynamic therapy	20
Design, synthesis and biological evaluation of oxadiazole clubbed piperazine derivatives as potential antidepressant agents	20
Application of cyclohexane-1,3-diones for six-membered oxygen-containing heterocycles synthesis	20
Design and synthesis of novel benzimidazole-iminosugars linked a substituted phenyl group and their inhibitory activities against β-glucosidase	20
Novel isatin-based hybrids as potential anti-rheumatoid arthritis drug candidates: Synthesis and biological evaluation	20
Evaluation of honokiol, magnolol and of a library of new nitrogenated neolignans as pancreatic lipase inhibitors	20
Coumarin thiazoles as unique structural skeleton of potential antimicrobial agents	20
Novel natural scaffold as hURAT1 inhibitor identified by 3D-shape-based, docking-based virtual screening approach and biological evaluation	20