Bioorganic Chemistry

Article	Citations
Editorial Board	175
Design, expression and biological evaluation of DX-88mut as a novel selective factor XIa inhibitor for antithrombosis	152
Structural optimization and biological evaluation of ML364 based derivatives as USP2a inhibitors	117
Structure-based optimization of TEAD inhibitors: Exploring a novel subpocket near Glu347 for the treatment of NF2-mutant cancer	104
Discovery of novel TLR4/MD-2 inhibitors: Receptor structure-based virtual screening studies and anti-inflammatory evaluation	88
Editorial Board	87
6-C-Linked trehalose glycolipids signal through Mincle and exhibit potent adjuvant activity	87
Mn-doped bimetallic synergistic catalysis boosts for enzymatic phosphorylation of N-Acetylglucosamine/ N-Acetylgalactosamine and their derivatives	83
Diversified applications and research progress of plant-derived natural products in PROTAC technology	83
Targeting nuclear receptor-binding SET domain protein 2 (NSD2) for cancer therapy: Challenges and emerging strategies	82
Dimethyl bisphenolate inhibits glioblastoma growth by promoting cell cycle arrest and apoptosis	81
Synthesis and biological evaluation of novel naproxen–phenacetin triazole hybrids as promising anti-inflammatory agents with enhanced gastrointestinal tolerability	80
Arylidine extensions of 3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-benzenesulfonamide derivatives: Synthesis, computational simulations and biological evaluation as tumor-associated carbonic anhydrase inhi	74
Casuattimines A–N, fourteen new Lycopodium alkaloids from Lycopodiastrum casuarinoides with Cav3.1 channel inhibitory activity	70
Construction of an AND logic gate fluorescent probe for highly efficient detection of formaldehyde and Pim-1 kinase	70
Synthesis of indomethacin thiadiazole urea derivatives and determination of GSTA4 inhibition and cytotoxic activity against colorectal carcinoma	69
Synthesis and in vitro leishmanicidal activity of novel N-arylspermidine derivatives	65
Design, synthesis and cytotoxic evaluation of new thieno[2,3-d]pyrimidine analogues as VEGFR-2/AKT dual inhibitors, apoptosis and autophagy inducers	63
Synergistic engineering of Nattokinase terminal and calcium-binding regions for enhanced catalytic performance and Oral stability	63
Investigations on isatin-pyrimidinone hybrids as novel lead compounds for selective inhibition of TrkA enzyme	61
Design, synthesis, in vitro, and in silico evaluation of multi-functionalized pyrimidines as potential multitarget-directed anti-inflammatory agents	60
Raphasemenate A-J: Ten phenylpropionates with antibacterial activity from Raphani Semen	59
A simple ratiometric fluorescent probe for two-photon imaging of carbon monoxide in living cells and zebrafish	59
Engineering an (R)-selective transaminase for asymmetric synthesis of (R)-3-aminobutanol	57
Corrigendum to “Synthesis and broad-spectrum biocidal effect of novel gemini quaternary ammonium compounds” [Bioorg Chem. 151 (2024) 107646]	57

Design, synthesis and biological evaluation of alkynyl-containing maleimide derivatives for the treatment of drug-resistant tuberculosis	55
A dual-responsive fluorescent probe for simultaneous detection of H2S and SO2 and its application in an oxidative stress model of neuronal cells	54
Design and synthesis of novel cyclohexanecarboxamides with anticonvulsant effect by activating Nrf2-ARE pathway	54
Corrigendum to “Nanogel delivered benzimidazole-triazole hybrids as potent multitarget inhibitors of topoisomerase and tubulin in triple-negative breast cancer” [Bioorg. Chem. 167 (2025) 109288]	52
Synthesis and biological evaluation of new nicotinic acid derivatives as potential anti-inflammatory agents with enhanced gastric safety profile	49
Optimized extraction, isolation and identification of bioactive sesquiterpenes from Inula racemosa	49
Elucidating the potential of novel class biphenyl-phenyl acetate, IDD-AN-A1, an inhibitor targeting Isocitrate Lyase in Mycobacterium tuberculosis: A target to lead approach	49
Quinolinyl-appended chalcones as promising antiproliferative and trypanocidal agents: Synthesis, biological profiling, and further transformation into novel benzo[f]pyrazolo[5,1-a][2,7]naphthyridine a	49
Carvacrol/thymol derivatives as highly selective BuChE inhibitors with anti-inflammatory activities: Discovery and bio-evaluation	49
Rational development of an ESIPT-based fluorescent probe with large Stokes shift for imaging of hydrogen sulfide in live cells	48
Functional characterization and regioselectivity manipulation of two Benzylisoquinoline alkaloids O-methyltransferases from Stephania yunnanensis	47
Terpenoids from of Euphorbia helioscopia L. with anti-Zika virus activity	47
Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa	47
Design, synthesis, and biological evaluation of novel FGFR1 PROTACs	46
Tetrahydrobenzothiophene derivatives ameliorate Mia PaCa-2 cell progression and induces apoptosis via inhibiting EGFR2 tyrosine kinase signal	46
Discovery of oleanolic acid derivatives that inhibit tau protein phosphorylation and neuroinflammation induced by Aβ25–35 in vitro and in vivo	46
Identification and molecular mechanism of novel 5-alkenyl-2-benzylaminothiazol-4(5H)-one analogs as anti-melanogenic and antioxidant agents	46
2-Trifluoromethyl-2H-chromene ethers: The dual triumph of anti-inflammation and analgesia with minimal ulcer threat	46
Ethyl-4-(aryl)-6-methyl-2-(oxo/thio)-3,4-dihydro-1H-pyrimidine-5-carboxylates: Silica supported bismuth(III)triflate catalyzed synthesis and antioxidant activity	45
One pot domino synthesis of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thiones (THTTs) as anti-inflammatory and antinociceptive candidates: A proof from in-vivo to in-vitro and in-silico	45
seco-Sesquiterpenes and acorane-type sesquiterpenes with antiviral activity from the twigs and leaves of Illicium henryi Diels	45
Seco-polyprenylated acylphloroglucinols from Hypericum elodeoides induced cell cycle arrest and apoptosis in MCF-7 cells via oxidative DNA damage	43
Renewable resource of sucrose with clusteroluminescence mechanism and applications	42
Novel thiazolopyridine derivatives of diflapolin as dual sEH/FLAP inhibitors with improved solubility	42
Discovery of neuroprotective Agents: Potent, brain Penetrating, lipoic acid derivatives for the potential treatment of ischemic stroke by regulating oxidative stress and inflammation - a Preliminary s	42
Novel dual-channel ratiometric fluorescence probe for SO2 detection in food and bioimaging applications based on FRET mechanism	42
Mechanism-guided discovery of chromene-chalcone hybrids targeting PKM2 and microtubules for breast cancer therapy	42
Rational design of novel procaspase-3 activators for the targeted therapy of triple-negative breast cancer	42
Benzalkonium disinfectants as emerging endocrine disruptors: Inhibition of 11β-Hydroxysteroid dehydrogenase 2 in human and rat models via steric and hydrophobic mechanisms: SPR and docking and enzymat	41
In vitro and in vivo studies on three new 8-hydroxyquinoline-based zinc(II) coordination compounds as potential antimelanoma cancer agents	41
Development of coumarin-based acetylcholinesterase inhibitors: Synthesis, biological assessment and computational simulations	41
Identification and bioactivity evaluation of miliusanes from Miliusa sinensis	40
A newly synthesized magnetic nanoparticle coated with glycidyl methacrylate monomer and 1,2,4-Triazole: Immobilization of α-Amylase from Bacillus licheniformis for more reuse, stability, and activity	40
De novo discovery and preclinical evaluation of a novel peptide radiotracer for PET imaging of TROP-2 in non-small cell lung cancer	40
Iron chelation and inhibition of metallopeptidases mediate anti-Trichomonas vaginalis activity by a novel 8-hydroxyquinoline derivative	40
Polydatin, a derivative of resveratrol, ameliorates busulfan-induced oligozoospermia in mice by inhibiting NF-κB pathway activation and suppressing ferroptosis	40
Strategies on boosting photothermal conversion efficiency of organic molecules for photothermal therapy	40
Discoidin domain receptor inhibitors as anticancer agents: A systematic review on recent development of DDRs inhibitors, their resistance and structure activity relationship	39
Recent advances in nitrogen-containing heterocyclic compounds as receptor tyrosine kinase inhibitors for the treatment of cancer: Biological activity and structural activity relationship	39
Structurally diverse phenylpropanoyl phloroglucinol derivatives from Mallotus philippensis and their anti-bacterial activities	39
Development and evaluation of chitosan conjugated Isatin-linked Pyrazole derivative to target anti-inflammatory and anti-fibrotic in ethanol induced liver fibrosis using an in-vivo zebra fish model	39
Design, synthesis, cytotoxic activities, and molecular docking of chalcone hybrids bearing 8-hydroxyquinoline moiety with dual tubulin/EGFR kinase inhibition	39
4-Phenylcoumarin derivatives as new HIV-1 NNRTIs: Design, synthesis, biological activities, and computational studies	38
Dihydroartemisinin suppresses metastatic potential and induces apoptosis in gastric adenocarcinoma: An integrative experimental and computational analysis revealing inhibition of MMP14 and promotion o	37
Discovery of novel benzofuro[3,2-b]quinoline derivatives as dual CDK2/Topo I inhibitors	37
Biocatalytic conversion of the natural compound bergamottin into novel bioactive epoxy-derivatives using engineered cytochrome P450 BM3	37
Rational design of new quinoline-benzimidazole scaffold bearing piperazine acetamide derivatives as antidiabetic agents	37
Targeted isolation and antipyretic mechanisms of 5,7,4′-trimethoxyflavone and p-hydroxybenzoic acid from Mimosa pudica root via cell membrane-coated magnetic carbon spheres integrated with thermal shi	37
Discovery of diverse sesquiterpenoids from Magnolia grandiflora with cytotoxic activities by inducing cell apoptosis	37
Design and synthesis of novel quinoline-chalcone derivatives as dual inhibitors of tubulin polymerization and P-glycoprotein to overcome cisplatin resistance in cervical cancer	37

Discovery of new 1,2,3,4-tetrahydro-β-carboline derivatives decorated with 3-N-substituted propionyl moiety flexibly bridged-chain as reactive oxygen species inducer for efficient antibacterial treatm	35
Design, synthesis and biological evaluation of oxadiazole clubbed piperazine derivatives as potential antidepressant agents	35
Discovery of new covalent inhibitors of monoacylglycerol lipase with the nitrile warhead via SCARdock	35
THP as a sensor for the electrochemical detection of H2O2	35
Peptide inhibitors of angiotensin-I converting enzyme based on angiotensin (1–7) with selectivity for the C-terminal domain	35
Design, synthesis, biological evaluation and docking study of some new aryl and heteroaryl thiomannosides as FimH antagonists	35
A chemoenzymatic process for preparation of highly purified dehydroepiandrosterone in high space-time yield	34
Design, synthesis and pharmacological evaluation of phenylthiophene-2-carboxamide-based RSV fusion protein inhibitors	34
Identification of diverse sesquiterpenoids with anti-fibrotic potential from Inula japonica Thunb.	33
Dihydro-β-agarofuran sesquiterpenoids from the root bark of Tripterygium wilfordii and their anti-neuroinflammatory activities	33
Repurposing tavaborole to combat resistant bacterial infections through competitive inhibition of KPC-2 and metabolic disruption	33
Syntheses and evaluation of acridone derivatives as anticancer agents targeting Kras promoter i-motif structure	33
Sulfonamidyl derivatives of sigmacidin: Protein-protein interaction inhibitors targeting bacterial RNA polymerase and sigma factor interaction exhibiting antimicrobial activity against antibiotic-resi	33
Efficient synthesis of artificial pharmaceutical solid-phase modules for constructing aptamer-drug conjugates	33
Discovery of 8-sulfonamidoquinolines as anti-proliferative agents against colorectal cancer: design, synthesis, and biological evaluation	33
Fatty acid chain modification enhances the serum stability of antimicrobial peptide B1 and activities against Staphylococcus aureus and Klebsiella pneumoniae	32
Ultra-fast responses NIR fluorescence chemosensor for monitoring HSO3−/SO2 and viscosity as well as its applications in real food samples and living biosystem	32
Dual inhibition of oxidative phosphorylation and glycolysis to enhance cancer therapy	32
Rosmarinic acid turned α-syn oligomers into non-toxic species preserving microtubules in Raw 264.7 cells	32
Design, synthesis, and biological evaluation of adenosine derivatives targeting DOT1L and HAT as anti-leukemia agents	31
Visualization of nonsmall-cell lung cancer by near-infrared fluorescence imaging with tumor-targeting peptide ABT-510	31
Synthesis, computational simulations and biological evaluation of new dual 5HT1A/5HT7 receptor ligands based on purine-2,6-dione scaffold	31
A bifunctional naphthalimide-based fluorescent probe for imaging lysosomal peroxynitrite and viscosity in living cells and zebrafish	31
Editorial Board	31
Buckyballs to fight pandemic: Water-soluble fullerene derivatives with pendant carboxylic groups emerge as a new family of promising SARS-CoV-2 inhibitors	31
Coumarin thiazoles as unique structural skeleton of potential antimicrobial agents	31
Multi-targeting oligopyridiniums: Rational design for biofilm dispersion and bacterial persister eradication	31
Synthesis and biological evaluation of novel isatin-phenol hybrids as potential antitumor agents	31
New pyrrolo[3,4-d] isoxazolidines hybrid with furan as antitumor agents and multi-target enzyme inhibitors: Synthesis and in silico study	31
Aromatase inhibitors for the treatment of breast cancer: An overview (2019–2023)	31
Design, synthesis, in vitro and in silico evaluation of thiazole-hydrazine hybrids incorporating an isoindole-1,3-dione scaffold as potent α-glucosidase inhibitors	30
Issue TOC	30
Issue TOC	30
Multimodal profiling of Pepcan-CB1 receptor structure-activity relationships: integrating molecular dynamics simulations, biological profiling, and the deep learning model MuMoPepcan	30
Inhibitory effect of liriopesides B in combination with gemcitabine on human pancreatic cancer cells	30
Artemzhongdianolides A1-A21, antihepatic fibrosis guaiane-type sesquiterpenoid dimers from Artemisia zhongdianensis	29
Bioactive Dioxo-Phosphobetaines derived from the reaction of Dichlorodinitrobenzofuroxane with various phosphines	29
Discovery of tetrasubstituted tetrahydropyrimidines as novel inhibitors against influenza a virus	29
Design, synthesis, and structure–activity relationships of xanthine derivatives as broad-spectrum inhibitors of coronavirus replication	29
Synthesis and anti-proliferative effect of novel 4-Aryl-1, 3-Thiazole-TPP conjugates via mitochondrial uncoupling process	29
A novel arylnaphthalene lignan analogue targets CYP51 to inhibit Cryptococcus neoformans growth	29
Design and synthesis of novel 2-S-alkylated Quinazolinones as dual BRAFV600E and EGFR inhibitors in melanoma: Mechanistic insights from apoptosis and cell cycle modulation	29
Targeting the epigenetic reader “BET” as a therapeutic strategy for cancer	29
Isomeric 2-isobutylmalate derivatives with anti-pulmonary fibrosis effects from the leaves of Bletilla striata via LC-MS/MS-based molecular networking	29
Mechanism of ginsenoside AD-1 improving pulmonary fibrosis by regulating the HIF-1α/ HSP/TGF-β1 signaling pathway and mesenchymal transition	29
Design, synthesis and biological evaluation of new 2,6-difluorinated phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new antimicrotubule agents	29
Design, Synthesis, Biocompatibility, molecular docking and molecular dynamics studies of novel Benzo[b]thiophene-2-carbaldehyde derivatives targeting human IgM Fc Domains	29
Discovery of novel Macrocyclic small molecules Based on 2-Amino-4-thiazolylpyridineas selective EGFR inhibitors with high Blood-Brain barrier penetration for the treatment of glioblastoma	29
Metabolism of natural and synthetic bioactive compounds in Cunninghamella fungi and their applications in drug discovery	29
Developing a golgi-targeted fluorescent probe for in situ visualization of the dynamic changes of H2S in cellular stress	29
Therapeutic applications and molecular mechanisms of TNIK inhibitors: A comprehensive review of current advances	29
Tripeptide linked dispiro cyclotriphosphazene conjugates: Synthesis, molecular docking analysis of compounds binding within cancer cell line receptors and in vitro cytotoxic and genotoxic activities	29
Site-directed double monoubiquitination of the repeat domain of the amyloid-forming protein tau impairs self-assembly and coacervation	29
Ugi reaction-assisted assembly of covalent PROTACs against glutathione peroxidase 4	28
Synthesis and evaluation of pentacyclic triterpenoids conjugates as novel HBV entry inhibitors targeting NTCP receptor	28
Novel Hsp90 inhibitors as leads for the development of radiotheragnostics for Meitner-Auger electron therapy	28
15-Hydroxyprostaglandin dehydrogenase inhibitor SW033291 ameliorates hepatic abnormal lipid metabolism, ER stress, and inflammation through PGE2/EP4 in T2DM mice	28
Unveiling the potential of novel natural product-based MTDLs that integrate cinnamamide scaffold as multifunctional agents for the treatment of Alzheimer's disease	28
Design, synthesis and evaluation of quinolone quaternary ammonium antibacterial agent with killing ability to biofilm	28
Site-selective sulfation of N-glycans by human GlcNAc-6-O-sulfotransferase 1 (CHST2) and chemoenzymatic synthesis of sulfated antibody glycoforms	28
Design and evaluation of DNA aptamers with “stem-loop-chain” structures for spectrum neutralization of ricin and abrin	28
Ginsenoside Rh4 inhibits breast cancer growth through targeting histone deacetylase 2 to regulate immune microenvironment and apoptosis	28
Sesquiterpene lactones from Elephantopus scaber exhibit cytotoxic effects on glioma cells by targeting GSTP1	28
Synthesis and preclinical evaluation of a novel probe [18F]AlF-NOTA-IPB-GPC3P for PET imaging of GPC3 positive tumor	28
Discovery of novel cycloalkyl-fused thiazole-based pyrimidine derivatives as highly potent CDK2 inhibitors with promising antitumor activity	28
Discovery of 6-amino pyridine clubbed heterocycles as potent dual GSK-3β/CK-1δ inhibitors for the treatment of Alzheimer's disease	28
CC1007, a small molecular compound, suppresses multiple myeloma via upregulation of Nur77	28
Synthesis of 2-chloropurine ribosides with chiral amino acid amides at C6 and their evaluation as A1 adenosine receptor agonists	27
Design, synthesis and biological evaluation of a novel non-Gemini analog of UVB1 and crystal structure of its complex with the vitamin D receptor	27
The insight into the intermolecular interactions between protamine and insulin lispro	27
Discovery of antitubercular potential of trans-3-indoleacrylic acid and its derivatives targeting Mycobacterium tuberculosis: A combined in vitro and in silico investigation	27
Issue TOC	27
Novel 2-oxoethylthio-sulfonamide derivatives targeting pyocyanin/staphyloxanthin producing-pathogens: Antibiofilm, DHPS inhibition and gamma radiation effects	27
Rational design, synthesis, biological evaluation, molecular docking, and molecular dynamics of substituted uracil derivatives as potent anti-cancer agents	27
Novel deep eutectic solvents promote enzyme-substrate molecular dynamic adaptation to enhance sucrose ester synthesis efficiency	27
Novel quinazolinone disulfide analogues as pqs quorum sensing inhibitors against Pseudomonas aeruginosa	27
Discovery of thioetomidate derivatives as rapid recovery hypnotics without adrenocortical suppression	27
Targeted discovery of diterpene compounds ostamycins with anti-influenza a viral activity from a deepsea-derived Streptomyces strain	27
Multifunctional porphyrin-substituted phenylalanine–phenylalanine nanoparticles for diagnostic and therapeutic applications in Alzheimer’s disease	27
Dual site reactivity of indole-3-Schiff bases with S/Se/Cl substituted ketenes for stereoselective C-4 substituted indole-β-lactams, biological evaluations, magic chloro effect and molecular docking s	26

Marine natural products with anti-MRSA activities: promising candidates for antibacterial drug discovery	26
Synthesis and bioevaluation of Scutellarein-Tertramethylpyrazine hybrid molecules for the treatment of ischemic stroke	26
TRK inhibitors in cancer therapeutics: Recent advances and future perspectives	26
Sustainable synthesis of ZnO and FexOy nanoparticles and their nanocomposite ZnFe2O4: Comprehensive characterization and applications in antioxidant activity and antibiotics degradation efficiency	26
Pleiotropically activation of azaphilone biosynthesis by overexpressing a pathway-specific transcription factor in marine-derived Aspergillus terreus RA2905	26
Copper-doped COF triggered bioorthogonal synergistic cancer therapy through apoptosis and cuproptosis	26
Isatin-pyrimidine hybrid derivatives as enoyl acyl carrier protein reductase (InhA) inhibitors against Mycobacterium tuberculosis	26
Identification of novel 3-aryl-1-aminoisoquinolines-based KRASG12C inhibitors: Rational drug design and expedient construction by C H functionalization/annulation	26
Hydantoin based dual inhibitors of ALR2 and PARP-1: Design, synthesis, in-vitro and in-vivo evaluation	26
Dual-functional near-infrared fluorescent probe for H2S detection and precise COX-2-positive cancer imaging	26
RNase H-sensitive multifunctional ASO-based constructs as promising tools for the treatment of multifactorial complex pathologies	26
Identification of CH2-linker modified desfluoroquinolone-aminopyrimidine hybrids to combat antibiotic-resistant gram-positive bacteria	26
New glycoconjugation strategies for Ruthenium(II) arene complexes via phosphane ligands and assessment of their antiproliferative activity	25
Targeting FUT1-mediated EGFR fucosylation and COX-2 reverses gemcitabine resistance by activating immunogenic cell death in hepatocellular carcinoma	25
Discovery of evodiamine derivatives as potential lead antifungal agents for the treatment of superficial fungal infections	25
Apigenin analogs as α-glucosidase inhibitors: Molecular docking, biochemical, enzyme kinetic, and an in vivo mouse model study	25
Design, synthesis and biological evaluation of coumarin derivatives as potential BRD4 inhibitors	25
Structural characterization of Typha latifolia polysaccharides and study on their mechanism of action in improving type 1 diabetes in mice	25
Design, synthesis and antitumor activity evaluation of novel modified 18β-glycyrrhetinate derivatives as PPARγ agonists	25
Advances in synthesis and biological evaluation of CDK2 inhibitors for cancer therapy	25
Oxidized tea polyphenol (OTP-3) targets EGFR synergistic nimotuzumab at inhibition of non-small cell lung tumor growth	25
Drugs repurposing: An approach to identify new hits against anticancer drug target TFIIH subunit p8	25
Enantiocomplementary synthesis of β-adrenergic blocker precursors via biocatalytic nitration of phenyl glycidyl ethers	25
SMART-guided discovery of Sarpagine-type monoterpene indole alkaloids from Rauvolfia vomitoria and the synergistic effects with cisplatin against human ovarian cancer cells	25
S-Alkylated sulfonium betulin derivatives: Synthesis, antibacterial activities, and wound healing applications	25
Design, synthesis, and anti-hepatocellular carcinoma activity evaluation of aryl Lenvatinib derivatives: Exploring potential VEGFR-2 inhibitors	25
Challenging the anticolorectal cancer capacity of quinoxaline-based scaffold via triazole ligation unveiled new efficient dual VEGFR-2/MAO-B inhibitors	25
PD0325901, an ERK inhibitor, attenuates RANKL‐induced osteoclast formation and mitigates cartilage inflammation by inhibiting the NF-κB and MAPK pathways	25
Combined PET and near-infrared fluorescence probe based on lapatinib targeting HER2 for in vivo tumor imaging	25
Gold nanoparticles-based targeted delivery of rapamycin and Olaparib to breast cancer: An in vitro and in vivo approach	25
Discovery of a novel Coumarin-Dihydroquinoxalone derivative MY-673 as a tubulin polymerization inhibitor capable of inhibiting the ERK pathway with potent anti-gastric cancer activities	25
Design and development of a bright NIR fluorescent probe for selective HSA detection in human blood serum and urine	25
Discovered cassane diterpenoids from Caesalpinia mimosoides lam. Exhibited anti-renal fibrosis activity via regulating TGF-β1/Smads signaling pathway	24
Identification of isatin-triazole-benzenesulfonamide hybrids as dual hCA IX/XII and c-met inhibitors with hypoxia-mediated chemo-sensitizing activity	24
Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents	24
A multi-route chemiluminescent probe for real-time imaging of β-amyloid pathology in Alzheimer's disease	24
Synthesis, X-ray, antioxidant, in-vitro biological & in-silico docking studies of novel organoselenides: Promising colorectal cancer inhibitors	24
Molecular glues targeting GSPT1 in cancers: A potent therapy	24
Volatile oils of Schisandra chinensis (Turcz.) Baill alleviates Parkinson's disease by activating the Nrf2 pathway to positively regulate autophagy and oxidative stress	24
Design, synthesis, and biological evaluation of novel amidoxime or amidine analogues of some 4-anilino-6,7-dimethoxyquinazolines with a potent EGFR inhibitory effect	24
Insights into the dual inhibitory effects of phenylethanoid glycosides from Osmanthus fragrans flower on glycolipid metabolizing enzymes	24
Issue TOC	24
Anti-proliferative tirucallane triterpenoids from gum resin of Boswellia sacra	24
In vitro α-amylase and α-glucosidase inhibition study of dihydropyrimidinones synthesized via one-pot Biginelli reaction in the presence of a green catalyst	24
Adenine nucleotides as potent and selective GPR17 modulators	24
Synthesis and evaluation of novel N1-acylated 5-(4-pyridinyl)indazole derivatives as potent and selective haspin inhibitors	24
Peniandrastins A–H: Andrastin-type meroterpenoids with immunosuppressive activity from a Penicillium sp.	24
Editorial Board	24
Aurora kinases, emerging critical targets for cancer treatment and related new therapeutic strategies	24
New ε-N-thioglutaryl-lysine derivatives as SIRT5 inhibitors: Chemical synthesis, kinetic and crystallographic studies	23
Functionalized magnetic particles coupled with LC-MS strategy facilitated discovery of trace thioalkaloids with potent immunosuppressive activity	23
Comprehensive evaluation of S-glyco-modification in vitro based on the potential impacts to Michael addition	23
Editorial Board	23
Molecular hybrids of substituted phenylcarbamoylpiperidine and 1,2,4-triazole methylacetamide as potent 15-LOX inhibitors: Design, synthesis, DFT calculations and molecular docking studies	23
Discovery of new 2-(3-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazole derivatives with potential analgesic and anti-inflammatory activities: In vitro, in vivo and in silico investigations	23
New indolin-2-ones, possessing sunitinib scaffold as HDAC inhibitors and anti-cancer agents with potential VEGFR inhibition activity; design, synthesis and biological evaluation	23
Ac34FGlcNAz is an effective metabolic chemical reporter for O-GlcNAcylated proteins with decreased S-glyco-modification	23
Recent advances and future perspectives of noncompetitive proteasome inhibitors	23
Synthesis, antimicrobial activity and in-silico studies of (1-(1-arylethyl)-1H-1,2,3-triazolyl-2-phenylquinoline-4-carboxylate derivatives with click chemistry	23
Editorial Board	23
Discovery of baicalein derivatives as novel covalent inhibitors of SARS CoV-2 Mpro: Structure-activity relationships and inhibitory mechanisms	23
Curcumol derivatives exhibit ameliorating effects on lipopolysaccharide-induced acute lung injury: Synthesis, biological evaluation, structure–activity relationship and action mechanism	23
1H NMR-guided isolation of hasubanan alkaloids from the alkaloidal extract of Stephania longa	23
Development of novel cyanopyridines as PIM-1 kinase inhibitors with potent anti-prostate cancer activity: Synthesis, biological evaluation, nanoparticles formulation and molecular dynamics simulation	23
Breast cancer cell targeted Pt(II) complexes: their bio-physical interaction and molecular docking with bio-receptors & HER2 cancer protein	23
Structure-activity relationship study of a series of nucleoside derivatives bearing sulfonamide scaffold as potent and selective PRMT5 inhibitors	23
Novel N or N modified α-carboline analogues as potential ligands in Alzheimer's disease therapy: Synthesis and neurobiological activity evaluation	22
Radiopharmaceuticals in Nasopharyngeal Cancer	22
New anti-inflammatory and non-cytotoxic metabolites of methylstenbolone obtained by microbial transformation	22
Hydroxamate and thiosemicarbazone: Two highly promising scaffolds for the development of SARS-CoV-2 antivirals	22
Development of new 1, 3-dihydroxyacridone derivatives as Akt pathway inhibitors in skeletal muscle cells	22
6-acrylic phenethyl ester-2-pyranone derivative induces apoptosis and G2/M arrest by targeting GRP94 in colorectal cancer	22
Sequential release of interacting proteins and Ub-modifying enzymes by disulfide heterotypic ubiquitin reagents	22
Hydrophilic and lipophilic colchicinoid formulations for therapy of liver fibrosis in murine model	22
Hybrid pharmacophore design and synthesis of donepezil-inspired aurone derivative salts as multifunctional acetylcholinesterase inhibitors	22
Inonotsutriol E from Inonotus obliquus exhibits promising anti breast cancer activity via regulating the JAK2/STAT3 signaling pathway	22
The first peptide derivatives of dioxybiphenyl-bridged spiro cyclotriphosphazenes: In vitro cytotoxicity activities and DNA damage studies	22
Pegriseofamines A−E: Five cyclopiazonic acid related indole alkaloids from the fungus Penicillium griseofulvum	22
7S,15R-Stereoisomer of phenylethylamino derivative of colchicine exhibits potent in-vitro and in-vivo anti-cancer activity against prostate Cancer: Assessing the impact of stereochemistry on biologica	22
On the tumor cell growth limiting potential of newly synthesized acridine-1,8-dione derivatives	22
Introduction of a β-leucine residue instead of leucine9 and glycine10 residues in Temporin L for improved cell selectivity, stability and activity against planktonic and biofilm of methicillin resista	22
Novel steroidal oximes as antiproliferative agents: Design, synthesis and biological activity evaluation	22
Design, synthesis, in vitro, and in silico enzymatic evaluations of thieno[2,3-b]quinoline-hydrazones as novel inhibitors for α-glucosidase	22
Anti-necroptosis and anti-ferroptosis compounds from the Deep-Sea-Derived fungus Aspergillus sp. MCCC 3A00392	22
Pomalidomide sensitizes lung cancer cells to TRAIL/CDDP-induced apoptosis via directly targeting electron transfer flavoprotein alpha subunit	22
Evolution of peptide YY analogs for the management of type 2 diabetes and obesity	22
Stable ubiquitin conjugation for biological interrogation of ubiquitinated tau repeat domain	21
UPLC-Q-TOF-MS/MS guided isolation of phyllanfranchins A–D, two pairs of undescribed cytotoxic dichapetalin hybrid triterpenoid epimers from Phyllanthus franchetianus	21
Protein coupled thionine acetate probed silica nanoparticles: An integrated laser-assisted therapeutic approach for treating cancer	21
Chalcone-inspired indole, carbazole, and phenothiazine hybrids as potent aldose reductase inhibitors with selective anticancer potential: Rational design, synthesis, and multi-level characterization	21
A novel near-infrared COX-2 targeting probe for tumor and metastatic lymph node monitoring	21
Design, synthesis and evaluation of quinazoline derivatives as Gαq/11 proteins inhibitors against uveal melanoma	21
Identification of new multi-substituted 1H-pyrazolo[3,4-c]pyridin-7(6H)-ones as soluble guanylyl cyclase (sGC) stimulators with vasoprotective and anti-inflammatory activities	21
In vitro activity and cell death mechanism induced by acrylonitrile derivatives against Leishmania amazonensis	21
Discovery of a novel CDK4/6 and HDAC dual-targeting agent for the treatment of hepatocellular carcinoma	21