Bioorganic Chemistry

Article	Citations
Editorial Board	140
Biocatalytic conversion of the natural compound bergamottin into novel bioactive epoxy-derivatives using engineered cytochrome P450 BM3	119
Targeted isolation and antipyretic mechanisms of 5,7,4′-trimethoxyflavone and p-hydroxybenzoic acid from Mimosa pudica root via cell membrane-coated magnetic carbon spheres integrated with thermal shi	93
Dihydroartemisinin suppresses metastatic potential and induces apoptosis in gastric adenocarcinoma: An integrative experimental and computational analysis revealing inhibition of MMP14 and promotion o	90
Functional characterization and regioselectivity manipulation of two Benzylisoquinoline alkaloids O-methyltransferases from Stephania yunnanensis	88
Discovery of neuroprotective Agents: Potent, brain Penetrating, lipoic acid derivatives for the potential treatment of ischemic stroke by regulating oxidative stress and inflammation - a Preliminary s	83
Corrigendum to “Synthesis and broad-spectrum biocidal effect of novel gemini quaternary ammonium compounds” [Bioorg Chem. 151 (2024) 107646]	76
Development and evaluation of chitosan conjugated Isatin-linked Pyrazole derivative to target anti-inflammatory and anti-fibrotic in ethanol induced liver fibrosis using an in-vivo zebra fish model	73
Peptide inhibitors of angiotensin-I converting enzyme based on angiotensin (1–7) with selectivity for the C-terminal domain	71
2-Trifluoromethyl-2H-chromene ethers: The dual triumph of anti-inflammation and analgesia with minimal ulcer threat	70
Discovery of diverse sesquiterpenoids from Magnolia grandiflora with cytotoxic activities by inducing cell apoptosis	69
Synthesis and biological evaluation of novel naproxen–phenacetin triazole hybrids as promising anti-inflammatory agents with enhanced gastrointestinal tolerability	68
Mechanism-guided discovery of chromene-chalcone hybrids targeting PKM2 and microtubules for breast cancer therapy	65
Design and synthesis of novel quinoline-chalcone derivatives as dual inhibitors of tubulin polymerization and P-glycoprotein to overcome cisplatin resistance in cervical cancer	65
Ultra-fast responses NIR fluorescence chemosensor for monitoring HSO3−/SO2 and viscosity as well as its applications in real food samples and living biosystem	64
Polydatin, a derivative of resveratrol, ameliorates busulfan-induced oligozoospermia in mice by inhibiting NF-κB pathway activation and suppressing ferroptosis	62
THP as a sensor for the electrochemical detection of H2O2	61
6-C-Linked trehalose glycolipids signal through Mincle and exhibit potent adjuvant activity	59
Biocatalytic one pot three component approach: Facile synthesis, characterization, molecular modelling and hypoglycemic studies of new thiazolidinedione festooned quinoline analogues catalyzed by alka	58
Recent advances in nitrogen-containing heterocyclic compounds as receptor tyrosine kinase inhibitors for the treatment of cancer: Biological activity and structural activity relationship	58
2-Methoxydiol derivatives as new tubulin and HDAC dual-targeting inhibitors, displaying antitumor and antiangiogenic response	58
Design, synthesis, cytotoxic activities, and molecular docking of chalcone hybrids bearing 8-hydroxyquinoline moiety with dual tubulin/EGFR kinase inhibition	57
Novel natural scaffold as hURAT1 inhibitor identified by 3D-shape-based, docking-based virtual screening approach and biological evaluation	56
Casuattimines A–N, fourteen new Lycopodium alkaloids from Lycopodiastrum casuarinoides with Cav3.1 channel inhibitory activity	56
Rosmarinic acid turned α-syn oligomers into non-toxic species preserving microtubules in Raw 264.7 cells	56

Synthesis of indomethacin thiadiazole urea derivatives and determination of GSTA4 inhibition and cytotoxic activity against colorectal carcinoma	55
Terpenoids from of Euphorbia helioscopia L. with anti-Zika virus activity	54
Construction of an AND logic gate fluorescent probe for highly efficient detection of formaldehyde and Pim-1 kinase	54
Renewable resource of sucrose with clusteroluminescence mechanism and applications	53
Dihydro-β-agarofuran sesquiterpenoids from the root bark of Tripterygium wilfordii and their anti-neuroinflammatory activities	52
Discovery of oleanolic acid derivatives that inhibit tau protein phosphorylation and neuroinflammation induced by Aβ25–35 in vitro and in vivo	52
Editorial Board	52
Design, synthesis and cytotoxic evaluation of new thieno[2,3-d]pyrimidine analogues as VEGFR-2/AKT dual inhibitors, apoptosis and autophagy inducers	52
Mn-doped bimetallic synergistic catalysis boosts for enzymatic phosphorylation of N-Acetylglucosamine/ N-Acetylgalactosamine and their derivatives	50
Sulfonamidyl derivatives of sigmacidin: Protein-protein interaction inhibitors targeting bacterial RNA polymerase and sigma factor interaction exhibiting antimicrobial activity against antibiotic-resi	49
Biotransformations of anthranilic acid and phthalimide to potent antihyperlipidemic alkaloids by the marine-derived fungus Scedosporium apiospermum F41-1	49
Design, expression and biological evaluation of DX-88mut as a novel selective factor XIa inhibitor for antithrombosis	48
seco-Sesquiterpenes and acorane-type sesquiterpenes with antiviral activity from the twigs and leaves of Illicium henryi Diels	48
Synthesis and biological evaluation of new nicotinic acid derivatives as potential anti-inflammatory agents with enhanced gastric safety profile	47
Ethyl-4-(aryl)-6-methyl-2-(oxo/thio)-3,4-dihydro-1H-pyrimidine-5-carboxylates: Silica supported bismuth(III)triflate catalyzed synthesis and antioxidant activity	46
Discovery of novel TLR4/MD-2 inhibitors: Receptor structure-based virtual screening studies and anti-inflammatory evaluation	46
Synthesis, structure and acetylcholinesterase inhibition activity of new diarylpyrazoles	46
Structural optimization and biological evaluation of ML364 based derivatives as USP2a inhibitors	46
Engineering an (R)-selective transaminase for asymmetric synthesis of (R)-3-aminobutanol	45
Efficient synthesis of artificial pharmaceutical solid-phase modules for constructing aptamer-drug conjugates	45
Rational design of new quinoline-benzimidazole scaffold bearing piperazine acetamide derivatives as antidiabetic agents	45
Repurposing tavaborole to combat resistant bacterial infections through competitive inhibition of KPC-2 and metabolic disruption	44
Development of anti-breast cancer PI3K inhibitors based on 7-azaindole derivatives through scaffold hopping: Design, synthesis and in vitro biological evaluation	44
Identification and molecular mechanism of novel 5-alkenyl-2-benzylaminothiazol-4(5H)-one analogs as anti-melanogenic and antioxidant agents	44
Structure-based optimization of TEAD inhibitors: Exploring a novel subpocket near Glu347 for the treatment of NF2-mutant cancer	44
Arylidine extensions of 3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-benzenesulfonamide derivatives: Synthesis, computational simulations and biological evaluation as tumor-associated carbonic anhydrase inhi	44
Discovery of new covalent inhibitors of monoacylglycerol lipase with the nitrile warhead via SCARdock	43
Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa	42
Synthesis and in vitro leishmanicidal activity of novel N-arylspermidine derivatives	42
Coumarin thiazoles as unique structural skeleton of potential antimicrobial agents	41
Identification and bioactivity evaluation of miliusanes from Miliusa sinensis	41
A near-infrared, colorimetric and ratiometric fluorescent sensor with high sensitivity to hydrogen peroxide and viscosity for solutions detection and imaging living cells	41
One pot domino synthesis of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thiones (THTTs) as anti-inflammatory and antinociceptive candidates: A proof from in-vivo to in-vitro and in-silico	40
Tetrahydrobenzothiophene derivatives ameliorate Mia PaCa-2 cell progression and induces apoptosis via inhibiting EGFR2 tyrosine kinase signal	40
Identification of diverse sesquiterpenoids with anti-fibrotic potential from Inula japonica Thunb.	39
Design, synthesis and biological evaluation of alkynyl-containing maleimide derivatives for the treatment of drug-resistant tuberculosis	39
A newly synthesized magnetic nanoparticle coated with glycidyl methacrylate monomer and 1,2,4-Triazole: Immobilization of α-Amylase from Bacillus licheniformis for more reuse, stability, and activity	39
Syntheses and evaluation of acridone derivatives as anticancer agents targeting Kras promoter i-motif structure	38
Structurally diverse phenylpropanoyl phloroglucinol derivatives from Mallotus philippensis and their anti-bacterial activities	38
Discoidin domain receptor inhibitors as anticancer agents: A systematic review on recent development of DDRs inhibitors, their resistance and structure activity relationship	38
Design, synthesis and biological evaluation of oxadiazole clubbed piperazine derivatives as potential antidepressant agents	38
4-Phenylcoumarin derivatives as new HIV-1 NNRTIs: Design, synthesis, biological activities, and computational studies	37
Iron chelation and inhibition of metallopeptidases mediate anti-Trichomonas vaginalis activity by a novel 8-hydroxyquinoline derivative	37
Design and synthesis of novel cyclohexanecarboxamides with anticonvulsant effect by activating Nrf2-ARE pathway	37
Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a mult	36
Design, synthesis, biological evaluation and docking study of some new aryl and heteroaryl thiomannosides as FimH antagonists	35
Rational development of an ESIPT-based fluorescent probe with large Stokes shift for imaging of hydrogen sulfide in live cells	35
Fatty acid chain modification enhances the serum stability of antimicrobial peptide B1 and activities against Staphylococcus aureus and Klebsiella pneumoniae	35
Discovery of new 1,2,3,4-tetrahydro-β-carboline derivatives decorated with 3-N-substituted propionyl moiety flexibly bridged-chain as reactive oxygen species inducer for efficient antibacterial treatm	35
A simple ratiometric fluorescent probe for two-photon imaging of carbon monoxide in living cells and zebrafish	35

A chemoenzymatic process for preparation of highly purified dehydroepiandrosterone in high space-time yield	35
Seco-polyprenylated acylphloroglucinols from Hypericum elodeoides induced cell cycle arrest and apoptosis in MCF-7 cells via oxidative DNA damage	35
Recent advances on the intervention sites targeting USP7-MDM2-p53 in cancer therapy	35
Novel thiazolopyridine derivatives of diflapolin as dual sEH/FLAP inhibitors with improved solubility	34
Carvacrol/thymol derivatives as highly selective BuChE inhibitors with anti-inflammatory activities: Discovery and bio-evaluation	34
In vitro and in vivo studies on three new 8-hydroxyquinoline-based zinc(II) coordination compounds as potential antimelanoma cancer agents	33
Discovery of linear unnatural peptides as potent mutant isocitrate dehydrogenase 1 inhibitors by Ugi reaction	33
Design, synthesis, and biological evaluation of novel FGFR1 PROTACs	33
Aromatase inhibitors for the treatment of breast cancer: An overview (2019–2023)	33
Novel dual-channel ratiometric fluorescence probe for SO2 detection in food and bioimaging applications based on FRET mechanism	33
Discovery of novel benzofuro[3,2-b]quinoline derivatives as dual CDK2/Topo I inhibitors	33
S-Alkylated sulfonium betulin derivatives: Synthesis, antibacterial activities, and wound healing applications	32
Design, synthesis, and anti-hepatocellular carcinoma activity evaluation of aryl Lenvatinib derivatives: Exploring potential VEGFR-2 inhibitors	32
Visualization of nonsmall-cell lung cancer by near-infrared fluorescence imaging with tumor-targeting peptide ABT-510	32
Activatable fluorescence molecular imaging and anti-tumor effects investigation of GSH-sensitive BRD4 ligands	32
Dual inhibition of oxidative phosphorylation and glycolysis to enhance cancer therapy	32
Buckyballs to fight pandemic: Water-soluble fullerene derivatives with pendant carboxylic groups emerge as a new family of promising SARS-CoV-2 inhibitors	32
Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics	32
Synthesis and evaluation of novel N1-acylated 5-(4-pyridinyl)indazole derivatives as potent and selective haspin inhibitors	32
Issue TOC	31
Issue TOC	31
Inhibitory effect of liriopesides B in combination with gemcitabine on human pancreatic cancer cells	30
Identification of novel 3-aryl-1-aminoisoquinolines-based KRASG12C inhibitors: Rational drug design and expedient construction by C H functionalization/annulation	30
Oxidized tea polyphenol (OTP-3) targets EGFR synergistic nimotuzumab at inhibition of non-small cell lung tumor growth	30
Tetrodecadazinone, a novel tetrodecamycin-pyridazinone hybrid with anti-liver fibrosis activity from Streptomyces sp. HU051	30
Synthesis and bioevaluation of Scutellarein-Tertramethylpyrazine hybrid molecules for the treatment of ischemic stroke	30
Multi-targeting oligopyridiniums: Rational design for biofilm dispersion and bacterial persister eradication	30
Developing a golgi-targeted fluorescent probe for in situ visualization of the dynamic changes of H2S in cellular stress	30
Synthesis and evaluation of pentacyclic triterpenoids conjugates as novel HBV entry inhibitors targeting NTCP receptor	29
Isomeric 2-isobutylmalate derivatives with anti-pulmonary fibrosis effects from the leaves of Bletilla striata via LC-MS/MS-based molecular networking	29
Design, synthesis and biological evaluation of a novel non-Gemini analog of UVB1 and crystal structure of its complex with the vitamin D receptor	29
Synthesis and anti-proliferative effect of novel 4-Aryl-1, 3-Thiazole-TPP conjugates via mitochondrial uncoupling process	29
Aurora kinases, emerging critical targets for cancer treatment and related new therapeutic strategies	29
Design, synthesis and antitumor activity evaluation of novel modified 18β-glycyrrhetinate derivatives as PPARγ agonists	29
Issue TOC	29
Identification of CH2-linker modified desfluoroquinolone-aminopyrimidine hybrids to combat antibiotic-resistant gram-positive bacteria	28
Design, synthesis and biological evaluation of new 2,6-difluorinated phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new antimicrotubule agents	28
Targeted discovery of diterpene compounds ostamycins with anti-influenza a viral activity from a deepsea-derived Streptomyces strain	28
Therapeutic applications and molecular mechanisms of TNIK inhibitors: A comprehensive review of current advances	28
Design and synthesis of novel 2-S-alkylated Quinazolinones as dual BRAFV600E and EGFR inhibitors in melanoma: Mechanistic insights from apoptosis and cell cycle modulation	28
Discovery of 6-amino pyridine clubbed heterocycles as potent dual GSK-3β/CK-1δ inhibitors for the treatment of Alzheimer's disease	28
Discovery of tetrasubstituted tetrahydropyrimidines as novel inhibitors against influenza a virus	28
Bioactive Dioxo-Phosphobetaines derived from the reaction of Dichlorodinitrobenzofuroxane with various phosphines	28
Design, synthesis, and structure–activity relationships of xanthine derivatives as broad-spectrum inhibitors of coronavirus replication	28
Ugi reaction-assisted assembly of covalent PROTACs against glutathione peroxidase 4	27
Cyclometalated Ru(II)-isoquinoline complexes overcome cisplatin resistance of A549/DDP cells by downregulation of Nrf2 via Akt/GSK-3β/Fyn pathway	27
Design, synthesis and biological evaluation of antitumor platinum(II) agents conjugated with non-steroidal anti-inflammatory drug species	27
Synthesis and biological evaluation of novel isatin-phenol hybrids as potential antitumor agents	27
Site-selective sulfation of N-glycans by human GlcNAc-6-O-sulfotransferase 1 (CHST2) and chemoenzymatic synthesis of sulfated antibody glycoforms	27
Apigenin analogs as α-glucosidase inhibitors: Molecular docking, biochemical, enzyme kinetic, and an in vivo mouse model study	27
Synthesis and preclinical evaluation of a novel probe [18F]AlF-NOTA-IPB-GPC3P for PET imaging of GPC3 positive tumor	27
15-Hydroxyprostaglandin dehydrogenase inhibitor SW033291 ameliorates hepatic abnormal lipid metabolism, ER stress, and inflammation through PGE2/EP4 in T2DM mice	26
The insight into the intermolecular interactions between protamine and insulin lispro	26
Synthesis of 2-chloropurine ribosides with chiral amino acid amides at C6 and their evaluation as A1 adenosine receptor agonists	26
Design, synthesis and biological evaluation of coumarin derivatives as potential BRD4 inhibitors	26
CC1007, a small molecular compound, suppresses multiple myeloma via upregulation of Nur77	26
Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents	26
Artemzhongdianolides A1-A21, antihepatic fibrosis guaiane-type sesquiterpenoid dimers from Artemisia zhongdianensis	26
Discovery of novel Macrocyclic small molecules Based on 2-Amino-4-thiazolylpyridineas selective EGFR inhibitors with high Blood-Brain barrier penetration for the treatment of glioblastoma	26
Pleiotropically activation of azaphilone biosynthesis by overexpressing a pathway-specific transcription factor in marine-derived Aspergillus terreus RA2905	26
Drugs repurposing: An approach to identify new hits against anticancer drug target TFIIH subunit p8	26
Tripeptide linked dispiro cyclotriphosphazene conjugates: Synthesis, molecular docking analysis of compounds binding within cancer cell line receptors and in vitro cytotoxic and genotoxic activities	26
Development of pteridin-7(8H)-one analogues as highly potent cyclin-dependent kinase 4/6 inhibitors: Synthesis, structure-activity relationship, and biological activity	26
Discovered cassane diterpenoids from Caesalpinia mimosoides lam. Exhibited anti-renal fibrosis activity via regulating TGF-β1/Smads signaling pathway	26
Isatin-pyrimidine hybrid derivatives as enoyl acyl carrier protein reductase (InhA) inhibitors against Mycobacterium tuberculosis	25
Synthesis, computational simulations and biological evaluation of new dual 5HT1A/5HT7 receptor ligands based on purine-2,6-dione scaffold	25
Design and development of a bright NIR fluorescent probe for selective HSA detection in human blood serum and urine	25
Design, Synthesis, Biocompatibility, molecular docking and molecular dynamics studies of novel Benzo[b]thiophene-2-carbaldehyde derivatives targeting human IgM Fc Domains	25
Challenging the anticolorectal cancer capacity of quinoxaline-based scaffold via triazole ligation unveiled new efficient dual VEGFR-2/MAO-B inhibitors	25
Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity	25
Design, synthesis, molecular docking and molecular dynamics studies of novel triazolothiadiazine derivatives containing furan or thiophene rings as anticancer agents	25
Issue TOC	25
Multimodal profiling of Pepcan-CB1 receptor structure-activity relationships: integrating molecular dynamics simulations, biological profiling, and the deep learning model MuMoPepcan	25
Design, synthesis and evaluation of quinolone quaternary ammonium antibacterial agent with killing ability to biofilm	25
Sesquiterpene lactones from Elephantopus scaber exhibit cytotoxic effects on glioma cells by targeting GSTP1	25
Hydantoin based dual inhibitors of ALR2 and PARP-1: Design, synthesis, in-vitro and in-vivo evaluation	25
Ginsenoside Rh4 inhibits breast cancer growth through targeting histone deacetylase 2 to regulate immune microenvironment and apoptosis	25
Development of potential anticancer agents and apoptotic inducers based on 4-aryl-4H chromene scaffold: Design, synthesis, biological evaluation and insight on their proliferation inhibition mechanism	25
A novel arylnaphthalene lignan analogue targets CYP51 to inhibit Cryptococcus neoformans growth	25
Targeting the epigenetic reader “BET” as a therapeutic strategy for cancer	25

Sustainable synthesis of ZnO and FexOy nanoparticles and their nanocomposite ZnFe2O4: Comprehensive characterization and applications in antioxidant activity and antibiotics degradation efficiency	25
Site-directed double monoubiquitination of the repeat domain of the amyloid-forming protein tau impairs self-assembly and coacervation	24
PD0325901, an ERK inhibitor, attenuates RANKL‐induced osteoclast formation and mitigates cartilage inflammation by inhibiting the NF-κB and MAPK pathways	24
Gold nanoparticles-based targeted delivery of rapamycin and Olaparib to breast cancer: An in vitro and in vivo approach	24
Multifunctional porphyrin-substituted phenylalanine–phenylalanine nanoparticles for diagnostic and therapeutic applications in Alzheimer’s disease	24
A bifunctional naphthalimide-based fluorescent probe for imaging lysosomal peroxynitrite and viscosity in living cells and zebrafish	24
Discovery of thioetomidate derivatives as rapid recovery hypnotics without adrenocortical suppression	24
Discovery of evodiamine derivatives as potential lead antifungal agents for the treatment of superficial fungal infections	24
Discovery of a novel Coumarin-Dihydroquinoxalone derivative MY-673 as a tubulin polymerization inhibitor capable of inhibiting the ERK pathway with potent anti-gastric cancer activities	24
Design, synthesis, and biological evaluation of adenosine derivatives targeting DOT1L and HAT as anti-leukemia agents	24
Peniandrastins A–H: Andrastin-type meroterpenoids with immunosuppressive activity from a Penicillium sp.	24
Combined PET and near-infrared fluorescence probe based on lapatinib targeting HER2 for in vivo tumor imaging	24
Dual site reactivity of indole-3-Schiff bases with S/Se/Cl substituted ketenes for stereoselective C-4 substituted indole-β-lactams, biological evaluations, magic chloro effect and molecular docking s	24
Development of 2′-aminospiro [pyrano[3,2–c]quinoline]-3′-carbonitrile derivatives as non-ATP competitive Src kinase inhibitors that suppress breast cancer cell migration and proliferation	24
Discovery of antitubercular potential of trans-3-indoleacrylic acid and its derivatives targeting Mycobacterium tuberculosis: A combined in vitro and in silico investigation	24
Enantiocomplementary synthesis of β-adrenergic blocker precursors via biocatalytic nitration of phenyl glycidyl ethers	24
Design, synthesis, and biological evaluation of novel amidoxime or amidine analogues of some 4-anilino-6,7-dimethoxyquinazolines with a potent EGFR inhibitory effect	24
New pyrrolo[3,4-d] isoxazolidines hybrid with furan as antitumor agents and multi-target enzyme inhibitors: Synthesis and in silico study	23
Advances in synthesis and biological evaluation of CDK2 inhibitors for cancer therapy	23
Probing the Ca2+ mobilizing properties on primary cortical neurons of a new stable cADPR mimic	23
Novel deep eutectic solvents promote enzyme-substrate molecular dynamic adaptation to enhance sucrose ester synthesis efficiency	23
Rational design, synthesis, biological evaluation, molecular docking, and molecular dynamics of substituted uracil derivatives as potent anti-cancer agents	23
Targeting FUT1-mediated EGFR fucosylation and COX-2 reverses gemcitabine resistance by activating immunogenic cell death in hepatocellular carcinoma	23
Identification of isatin-triazole-benzenesulfonamide hybrids as dual hCA IX/XII and c-met inhibitors with hypoxia-mediated chemo-sensitizing activity	23
Design, synthesis and bioactivity evaluation of thiazolidinedione derivatives as partial agonists targeting PPARγ	23
RNase H-sensitive multifunctional ASO-based constructs as promising tools for the treatment of multifactorial complex pathologies	23
Metabolism of natural and synthetic bioactive compounds in Cunninghamella fungi and their applications in drug discovery	23
Volatile oils of Schisandra chinensis (Turcz.) Baill alleviates Parkinson's disease by activating the Nrf2 pathway to positively regulate autophagy and oxidative stress	23
New glycoconjugation strategies for Ruthenium(II) arene complexes via phosphane ligands and assessment of their antiproliferative activity	23
Unveiling the potential of novel natural product-based MTDLs that integrate cinnamamide scaffold as multifunctional agents for the treatment of Alzheimer's disease	23
In vitro α-amylase and α-glucosidase inhibition study of dihydropyrimidinones synthesized via one-pot Biginelli reaction in the presence of a green catalyst	23
Novel quinazolinone disulfide analogues as pqs quorum sensing inhibitors against Pseudomonas aeruginosa	23
Molecular glues targeting GSPT1 in cancers: A potent therapy	23
Tryptanthrins as multi-bioactive agents: discovery, diversity distribution and synthesis	22
Discovery of natural product-like spirooxindole derivatives as highly potent and selective LSD1/KDM1A inhibitors for AML treatment	22
New resveratrol analogs as improved biologically active structures: Design, synthesis and computational modeling	22
Comprehensive evaluation of S-glyco-modification in vitro based on the potential impacts to Michael addition	22
Chiral resolution of (R, S)-1-chloro-1-phenylethane by haloalkane dehalogenase DbjA in micro-aqueous phase	22
Design and evaluation of novel inhibitors for the treatment of clear cell renal cell carcinoma	22
A multi-route chemiluminescent probe for real-time imaging of β-amyloid pathology in Alzheimer's disease	22
Introduction of a β-leucine residue instead of leucine9 and glycine10 residues in Temporin L for improved cell selectivity, stability and activity against planktonic and biofilm of methicillin resista	22
Protein coupled thionine acetate probed silica nanoparticles: An integrated laser-assisted therapeutic approach for treating cancer	22
Structure-activity relationship study of a series of nucleoside derivatives bearing sulfonamide scaffold as potent and selective PRMT5 inhibitors	22
Synthesis and evaluation of 3-(phenylethynyl)-1,1′-biphenyl-2-carboxylate derivatives as new HIF-1 inhibitors	22
Novel partially reversible NDM-1 inhibitors based on the naturally occurring houttuynin	22
Discovery of baicalein derivatives as novel covalent inhibitors of SARS CoV-2 Mpro: Structure-activity relationships and inhibitory mechanisms	22
Meta-substituted piperlongumine derivatives attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis	22
Development and biological evaluation of 68Ga-labeled peptides for potential application in HER2-positive colorectal cancer	22
Chelerythrine may bind to KRAS mRNA G-quadruplex in the cisplatin-resistant non-small cell lung cancer cells	22
Gracillin induces mitochondria-mediated apoptosis on pancreatic ductal adenocarcinoma through disruption of redox homeostasis via inhibiting NRF2/HO-1 antioxidant axis	22
Stable ubiquitin conjugation for biological interrogation of ubiquitinated tau repeat domain	22
Radiopharmaceuticals in Nasopharyngeal Cancer	22
Discovery of a novel CDK4/6 and HDAC dual-targeting agent for the treatment of hepatocellular carcinoma	22
Polydatin sensitizes osteosarcoma cells to methotrexate through suppressing the H19/H3K27me3/H3K9me3 mediated folate metabolism regulatory axis	22
Pomalidomide sensitizes lung cancer cells to TRAIL/CDDP-induced apoptosis via directly targeting electron transfer flavoprotein alpha subunit	22
On the tumor cell growth limiting potential of newly synthesized acridine-1,8-dione derivatives	22
Development of bifunctional anti-PD-L1 antibody MMAE conjugate with cytotoxicity and immunostimulation	22
Inonotsutriol E from Inonotus obliquus exhibits promising anti breast cancer activity via regulating the JAK2/STAT3 signaling pathway	22
The first peptide derivatives of dioxybiphenyl-bridged spiro cyclotriphosphazenes: In vitro cytotoxicity activities and DNA damage studies	22
Issue TOC	21
Editorial Board	21
Resorcylic acid lactones from a Podospora sp. that induce apoptosis in activated T cells through MAPKs/AKT pathway	21
Discovery of a novel OGT inhibitor through high-throughput screening based on Homogeneous Time-Resolved Fluorescence (HTRF)	21
Membrane mechanism of temporin-1CEc, an antimicrobial peptide isolated from the skin secretions of Rana chensinensis, and its systemic analogs	21
Brujavanoids A–U, structurally diverse apotirucallane-type triterpenoids from Brucea javanica and their anti-inflammatory effects	21
Chalcone-inspired indole, carbazole, and phenothiazine hybrids as potent aldose reductase inhibitors with selective anticancer potential: Rational design, synthesis, and multi-level characterization	21
Ac34FGlcNAz is an effective metabolic chemical reporter for O-GlcNAcylated proteins with decreased S-glyco-modification	21
Synthesis, structural, multitargeted molecular docking analysis of anti-cancer, anti-tubercular, DNA interactions of benzotriazole based macrocyclic ligand	21
Mitochondrial targeted modification and anticancer mechanism of natural product ergosterol peroxide	21
Combined active pocket and hinge region engineering to develop an NADPH-dependent phenylglycine dehydrogenase	21
New phosphoramides containing imidazolidine moiety as anticancer agents: An experimental and computational study	21
New ε-N-thioglutaryl-lysine derivatives as SIRT5 inhibitors: Chemical synthesis, kinetic and crystallographic studies	21
Novel N or N modified α-carboline analogues as potential ligands in Alzheimer's disease therapy: Synthesis and neurobiological activity evaluation	21
Development of new 1, 3-dihydroxyacridone derivatives as Akt pathway inhibitors in skeletal muscle cells	21
Interactions of isoorientin and its Semi-synthetic analogs with human serum albumin	21
Photosensitizer-based small molecule theranostic agents for tumor-targeted monitoring and phototherapy	21
Evolution of peptide YY analogs for the management of type 2 diabetes and obesity	21
1H NMR-guided isolation of hasubanan alkaloids from the alkaloidal extract of Stephania longa	21
Double-edged Swords: Diaryl pyrazoline thiazolidinediones synchronously targeting cancer epigenetics and angiogenesis	21
Sequential release of interacting proteins and Ub-modifying enzymes by disulfide heterotypic ubiquitin reagents	21
Novel steroidal oximes as antiproliferative agents: Design, synthesis and biological activity evaluation	21
New anti-inflammatory and non-cytotoxic metabolites of methylstenbolone obtained by microbial transformation	21
Corrigendum to “Design and synthesis of novel isatin-based derivatives targeting cell cycle checkpoint pathways as potential anticancer agents” [Bioorg. Chem. 105 (2020) 104366]	21
Recent advances in targeting leucine-rich repeat kinase 2 as a potential strategy for the treatment of Parkinson’s disease	21
Benzoxazole-appended piperidine derivatives as novel anticancer candidates against breast cancer	21
Design and development of benzyl piperazine linked 5-phenyl-1,2,4-triazole-3-thione conjugates as potential agents to combat Alzheimer’s disease	21
Discovery of ARS-1620 analogs as KRas G12C inhibitors with high in vivo antitumor activity	21
Synthesis, molecular docking and biological evaluation of 1,2,4-oxadiazole based novel non-steroidal derivatives against prostate cancer	21
Synthesis of novel calcium channel blockers with ACE2 inhibition and dual antihypertensive/anti-inflammatory effects: A possible therapeutic tool for COVID-19	21
Novel thiophene Chalcones-Coumarin as acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, molecular docking, ADMET prediction and molecular dynamics simulation	21
Synthesis and in vitro evaluation of chlorogenic acid amides as potential hypoglycemic agents and their synergistic effect with acarbose	20
1,2,3-Triazolo[4,5-b]aminoquinolines: Design, synthesis, structure, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity, and molecular docking of novel modified tacrines	20
Discovery of ent-kaurane diterpenoid glucosides as potent analgesics from the leaves of Pieris formosa	20
Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors	20
Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars	20