OOIR: Observatory of International Research

Papers

(The H4-Index of Bioorganic Chemistry is 45. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Editorial Board	175
Design, expression and biological evaluation of DX-88mut as a novel selective factor XIa inhibitor for antithrombosis	152
Structural optimization and biological evaluation of ML364 based derivatives as USP2a inhibitors	117
Structure-based optimization of TEAD inhibitors: Exploring a novel subpocket near Glu347 for the treatment of NF2-mutant cancer	104
Discovery of novel TLR4/MD-2 inhibitors: Receptor structure-based virtual screening studies and anti-inflammatory evaluation	88
Editorial Board	87
6-C-Linked trehalose glycolipids signal through Mincle and exhibit potent adjuvant activity	87
Diversified applications and research progress of plant-derived natural products in PROTAC technology	83
Mn-doped bimetallic synergistic catalysis boosts for enzymatic phosphorylation of N-Acetylglucosamine/ N-Acetylgalactosamine and their derivatives	83
Targeting nuclear receptor-binding SET domain protein 2 (NSD2) for cancer therapy: Challenges and emerging strategies	82
Dimethyl bisphenolate inhibits glioblastoma growth by promoting cell cycle arrest and apoptosis	81
Synthesis and biological evaluation of novel naproxen–phenacetin triazole hybrids as promising anti-inflammatory agents with enhanced gastrointestinal tolerability	80
Arylidine extensions of 3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-benzenesulfonamide derivatives: Synthesis, computational simulations and biological evaluation as tumor-associated carbonic anhydrase inhi	74
Construction of an AND logic gate fluorescent probe for highly efficient detection of formaldehyde and Pim-1 kinase	70
Casuattimines A–N, fourteen new Lycopodium alkaloids from Lycopodiastrum casuarinoides with Cav3.1 channel inhibitory activity	70
Synthesis of indomethacin thiadiazole urea derivatives and determination of GSTA4 inhibition and cytotoxic activity against colorectal carcinoma	69
Synthesis and in vitro leishmanicidal activity of novel N-arylspermidine derivatives	65
Design, synthesis and cytotoxic evaluation of new thieno[2,3-d]pyrimidine analogues as VEGFR-2/AKT dual inhibitors, apoptosis and autophagy inducers	63
Synergistic engineering of Nattokinase terminal and calcium-binding regions for enhanced catalytic performance and Oral stability	63
Investigations on isatin-pyrimidinone hybrids as novel lead compounds for selective inhibition of TrkA enzyme	61
Design, synthesis, in vitro, and in silico evaluation of multi-functionalized pyrimidines as potential multitarget-directed anti-inflammatory agents	60
Raphasemenate A-J: Ten phenylpropionates with antibacterial activity from Raphani Semen	59
A simple ratiometric fluorescent probe for two-photon imaging of carbon monoxide in living cells and zebrafish	59
Corrigendum to “Synthesis and broad-spectrum biocidal effect of novel gemini quaternary ammonium compounds” [Bioorg Chem. 151 (2024) 107646]	57
Engineering an (R)-selective transaminase for asymmetric synthesis of (R)-3-aminobutanol	57

Design, synthesis and biological evaluation of alkynyl-containing maleimide derivatives for the treatment of drug-resistant tuberculosis	55
Design and synthesis of novel cyclohexanecarboxamides with anticonvulsant effect by activating Nrf2-ARE pathway	54
A dual-responsive fluorescent probe for simultaneous detection of H2S and SO2 and its application in an oxidative stress model of neuronal cells	54
Corrigendum to “Nanogel delivered benzimidazole-triazole hybrids as potent multitarget inhibitors of topoisomerase and tubulin in triple-negative breast cancer” [Bioorg. Chem. 167 (2025) 109288]	52
Elucidating the potential of novel class biphenyl-phenyl acetate, IDD-AN-A1, an inhibitor targeting Isocitrate Lyase in Mycobacterium tuberculosis: A target to lead approach	49
Quinolinyl-appended chalcones as promising antiproliferative and trypanocidal agents: Synthesis, biological profiling, and further transformation into novel benzo[f]pyrazolo[5,1-a][2,7]naphthyridine a	49
Carvacrol/thymol derivatives as highly selective BuChE inhibitors with anti-inflammatory activities: Discovery and bio-evaluation	49
Synthesis and biological evaluation of new nicotinic acid derivatives as potential anti-inflammatory agents with enhanced gastric safety profile	49
Optimized extraction, isolation and identification of bioactive sesquiterpenes from Inula racemosa	49
Rational development of an ESIPT-based fluorescent probe with large Stokes shift for imaging of hydrogen sulfide in live cells	48
Terpenoids from of Euphorbia helioscopia L. with anti-Zika virus activity	47
Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa	47
Functional characterization and regioselectivity manipulation of two Benzylisoquinoline alkaloids O-methyltransferases from Stephania yunnanensis	47
Discovery of oleanolic acid derivatives that inhibit tau protein phosphorylation and neuroinflammation induced by Aβ25–35 in vitro and in vivo	46
Identification and molecular mechanism of novel 5-alkenyl-2-benzylaminothiazol-4(5H)-one analogs as anti-melanogenic and antioxidant agents	46
2-Trifluoromethyl-2H-chromene ethers: The dual triumph of anti-inflammation and analgesia with minimal ulcer threat	46
Design, synthesis, and biological evaluation of novel FGFR1 PROTACs	46
Tetrahydrobenzothiophene derivatives ameliorate Mia PaCa-2 cell progression and induces apoptosis via inhibiting EGFR2 tyrosine kinase signal	46
One pot domino synthesis of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thiones (THTTs) as anti-inflammatory and antinociceptive candidates: A proof from in-vivo to in-vitro and in-silico	45
seco-Sesquiterpenes and acorane-type sesquiterpenes with antiviral activity from the twigs and leaves of Illicium henryi Diels	45
Ethyl-4-(aryl)-6-methyl-2-(oxo/thio)-3,4-dihydro-1H-pyrimidine-5-carboxylates: Silica supported bismuth(III)triflate catalyzed synthesis and antioxidant activity	45