OOIR: Observatory of International Research

Papers

(The H4-Index of Bioorganic Chemistry is 45. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Editorial Board	171
A chemoenzymatic process for preparation of highly purified dehydroepiandrosterone in high space-time yield	148
Synthesis and biological evaluation of novel naproxen–phenacetin triazole hybrids as promising anti-inflammatory agents with enhanced gastrointestinal tolerability	116
Arylidine extensions of 3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-benzenesulfonamide derivatives: Synthesis, computational simulations and biological evaluation as tumor-associated carbonic anhydrase inhi	101
Design, synthesis and biological evaluation of oxadiazole clubbed piperazine derivatives as potential antidepressant agents	86
De novo discovery and preclinical evaluation of a novel peptide radiotracer for PET imaging of TROP-2 in non-small cell lung cancer	85
THP as a sensor for the electrochemical detection of H2O2	85
Repurposing tavaborole to combat resistant bacterial infections through competitive inhibition of KPC-2 and metabolic disruption	83
Coumarin thiazoles as unique structural skeleton of potential antimicrobial agents	80
Synergistic engineering of Nattokinase terminal and calcium-binding regions for enhanced catalytic performance and Oral stability	80
Discoidin domain receptor inhibitors as anticancer agents: A systematic review on recent development of DDRs inhibitors, their resistance and structure activity relationship	77
Design, synthesis, biological evaluation and docking study of some new aryl and heteroaryl thiomannosides as FimH antagonists	75
Design and synthesis of novel quinoline-chalcone derivatives as dual inhibitors of tubulin polymerization and P-glycoprotein to overcome cisplatin resistance in cervical cancer	74
Structural optimization and biological evaluation of ML364 based derivatives as USP2a inhibitors	70
Design, expression and biological evaluation of DX-88mut as a novel selective factor XIa inhibitor for antithrombosis	70
Efficient synthesis of artificial pharmaceutical solid-phase modules for constructing aptamer-drug conjugates	67
Syntheses and evaluation of acridone derivatives as anticancer agents targeting Kras promoter i-motif structure	65
Structure-based optimization of TEAD inhibitors: Exploring a novel subpocket near Glu347 for the treatment of NF2-mutant cancer	63
Discovery of novel TLR4/MD-2 inhibitors: Receptor structure-based virtual screening studies and anti-inflammatory evaluation	62
Rational design of new quinoline-benzimidazole scaffold bearing piperazine acetamide derivatives as antidiabetic agents	62
Diversified applications and research progress of plant-derived natural products in PROTAC technology	61
Engineering an (R)-selective transaminase for asymmetric synthesis of (R)-3-aminobutanol	60
Identification of diverse sesquiterpenoids with anti-fibrotic potential from Inula japonica Thunb.	59
Strategies on boosting photothermal conversion efficiency of organic molecules for photothermal therapy	57
Design, synthesis and biological evaluation of alkynyl-containing maleimide derivatives for the treatment of drug-resistant tuberculosis	57

Design and synthesis of novel cyclohexanecarboxamides with anticonvulsant effect by activating Nrf2-ARE pathway	55
Corrigendum to “Synthesis and broad-spectrum biocidal effect of novel gemini quaternary ammonium compounds” [Bioorg Chem. 151 (2024) 107646]	55
Aromatase inhibitors for the treatment of breast cancer: An overview (2019–2023)	53
Synthesis and in vitro leishmanicidal activity of novel N-arylspermidine derivatives	53
Recent advances in nitrogen-containing heterocyclic compounds as receptor tyrosine kinase inhibitors for the treatment of cancer: Biological activity and structural activity relationship	52
Design, synthesis, and biological evaluation of novel FGFR1 PROTACs	50
2-Trifluoromethyl-2H-chromene ethers: The dual triumph of anti-inflammation and analgesia with minimal ulcer threat	48
Discovery of oleanolic acid derivatives that inhibit tau protein phosphorylation and neuroinflammation induced by Aβ25–35 in vitro and in vivo	48
Ethyl-4-(aryl)-6-methyl-2-(oxo/thio)-3,4-dihydro-1H-pyrimidine-5-carboxylates: Silica supported bismuth(III)triflate catalyzed synthesis and antioxidant activity	48
Novel thiazolopyridine derivatives of diflapolin as dual sEH/FLAP inhibitors with improved solubility	47
Rational design of novel procaspase-3 activators for the targeted therapy of triple-negative breast cancer	46
Seco-polyprenylated acylphloroglucinols from Hypericum elodeoides induced cell cycle arrest and apoptosis in MCF-7 cells via oxidative DNA damage	46
Novel dual-channel ratiometric fluorescence probe for SO2 detection in food and bioimaging applications based on FRET mechanism	46
Structurally diverse phenylpropanoyl phloroglucinol derivatives from Mallotus philippensis and their anti-bacterial activities	45
Raphasemenate A-J: Ten phenylpropionates with antibacterial activity from Raphani Semen	45
Identification and molecular mechanism of novel 5-alkenyl-2-benzylaminothiazol-4(5H)-one analogs as anti-melanogenic and antioxidant agents	45
Iron chelation and inhibition of metallopeptidases mediate anti-Trichomonas vaginalis activity by a novel 8-hydroxyquinoline derivative	45
seco-Sesquiterpenes and acorane-type sesquiterpenes with antiviral activity from the twigs and leaves of Illicium henryi Diels	45
Casuattimines A–N, fourteen new Lycopodium alkaloids from Lycopodiastrum casuarinoides with Cav3.1 channel inhibitory activity	45
Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa	45