OOIR: Observatory of International Research

Papers

(The H4-Index of Bioorganic Chemistry is 45. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Editorial Board	184
Design, expression and biological evaluation of DX-88mut as a novel selective factor XIa inhibitor for antithrombosis	123
Discovery of novel TLR4/MD-2 inhibitors: Receptor structure-based virtual screening studies and anti-inflammatory evaluation	111
Editorial Board	103
Targeting nuclear receptor-binding SET domain protein 2 (NSD2) for cancer therapy: Challenges and emerging strategies	93
Dimethyl bisphenolate inhibits glioblastoma growth by promoting cell cycle arrest and apoptosis	93
Casuattimines A–N, fourteen new Lycopodium alkaloids from Lycopodiastrum casuarinoides with Cav3.1 channel inhibitory activity	86
Synthesis and biological evaluation of novel naproxen–phenacetin triazole hybrids as promising anti-inflammatory agents with enhanced gastrointestinal tolerability	86
Construction of an AND logic gate fluorescent probe for highly efficient detection of formaldehyde and Pim-1 kinase	84
Synthesis and in vitro leishmanicidal activity of novel N-arylspermidine derivatives	79
Investigations on isatin-pyrimidinone hybrids as novel lead compounds for selective inhibition of TrkA enzyme	73
Design, synthesis, in vitro, and in silico evaluation of multi-functionalized pyrimidines as potential multitarget-directed anti-inflammatory agents	71
Corrigendum to “Synthesis and broad-spectrum biocidal effect of novel gemini quaternary ammonium compounds” [Bioorg Chem. 151 (2024) 107646]	68
Design, synthesis and biological evaluation of alkynyl-containing maleimide derivatives for the treatment of drug-resistant tuberculosis	66
Synthesis and biological evaluation of new nicotinic acid derivatives as potential anti-inflammatory agents with enhanced gastric safety profile	65
Corrigendum to “Nanogel delivered benzimidazole-triazole hybrids as potent multitarget inhibitors of topoisomerase and tubulin in triple-negative breast cancer” [Bioorg. Chem. 167 (2025) 109288]	65
Optimized extraction, isolation and identification of bioactive sesquiterpenes from Inula racemosa	64
Quinolinyl-appended chalcones as promising antiproliferative and trypanocidal agents: Synthesis, biological profiling, and further transformation into novel benzo[f]pyrazolo[5,1-a][2,7]naphthyridine a	64
Elucidating the potential of novel class biphenyl-phenyl acetate, IDD-AN-A1, an inhibitor targeting Isocitrate Lyase in Mycobacterium tuberculosis: A target to lead approach	64
Rational development of an ESIPT-based fluorescent probe with large Stokes shift for imaging of hydrogen sulfide in live cells	62
Discovery of novel benzofuro[3,2-b]quinoline derivatives as dual CDK2/Topo I inhibitors	60
Terpenoids from of Euphorbia helioscopia L. with anti-Zika virus activity	60
Targeted isolation and antipyretic mechanisms of 5,7,4′-trimethoxyflavone and p-hydroxybenzoic acid from Mimosa pudica root via cell membrane-coated magnetic carbon spheres integrated with thermal shi	59
Design and synthesis of novel quinoline-chalcone derivatives as dual inhibitors of tubulin polymerization and P-glycoprotein to overcome cisplatin resistance in cervical cancer	56
Biocatalytic conversion of the natural compound bergamottin into novel bioactive epoxy-derivatives using engineered cytochrome P450 BM3	56

Peptide inhibitors of angiotensin-I converting enzyme based on angiotensin (1–7) with selectivity for the C-terminal domain	55
Discovery of new 1,2,3,4-tetrahydro-β-carboline derivatives decorated with 3-N-substituted propionyl moiety flexibly bridged-chain as reactive oxygen species inducer for efficient antibacterial treatm	54
Design, synthesis and pharmacological evaluation of phenylthiophene-2-carboxamide-based RSV fusion protein inhibitors	52
A chemoenzymatic process for preparation of highly purified dehydroepiandrosterone in high space-time yield	52
Repurposing tavaborole to combat resistant bacterial infections through competitive inhibition of KPC-2 and metabolic disruption	51
Syntheses and evaluation of acridone derivatives as anticancer agents targeting Kras promoter i-motif structure	51
Discovery of 8-sulfonamidoquinolines as anti-proliferative agents against colorectal cancer: design, synthesis, and biological evaluation	51
Identification of diverse sesquiterpenoids with anti-fibrotic potential from Inula japonica Thunb.	51
Identification and molecular mechanism of novel 5-alkenyl-2-benzylaminothiazol-4(5H)-one analogs as anti-melanogenic and antioxidant agents	50
2-Trifluoromethyl-2H-chromene ethers: The dual triumph of anti-inflammation and analgesia with minimal ulcer threat	50
Tetrahydrobenzothiophene derivatives ameliorate Mia PaCa-2 cell progression and induces apoptosis via inhibiting EGFR2 tyrosine kinase signal	50
Ethyl-4-(aryl)-6-methyl-2-(oxo/thio)-3,4-dihydro-1H-pyrimidine-5-carboxylates: Silica supported bismuth(III)triflate catalyzed synthesis and antioxidant activity	49
seco-Sesquiterpenes and acorane-type sesquiterpenes with antiviral activity from the twigs and leaves of Illicium henryi Diels	48
One pot domino synthesis of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thiones (THTTs) as anti-inflammatory and antinociceptive candidates: A proof from in-vivo to in-vitro and in-silico	48
Mechanism-guided discovery of chromene-chalcone hybrids targeting PKM2 and microtubules for breast cancer therapy	47
Seco-polyprenylated acylphloroglucinols from Hypericum elodeoides induced cell cycle arrest and apoptosis in MCF-7 cells via oxidative DNA damage	47
Rational design of novel procaspase-3 activators for the targeted therapy of triple-negative breast cancer	47
Benzalkonium disinfectants as emerging endocrine disruptors: Inhibition of 11β-Hydroxysteroid dehydrogenase 2 in human and rat models via steric and hydrophobic mechanisms: SPR and docking and enzymat	46
De novo discovery and preclinical evaluation of a novel peptide radiotracer for PET imaging of TROP-2 in non-small cell lung cancer	46
Identification and bioactivity evaluation of miliusanes from Miliusa sinensis	45
Efficient synthesis of artificial pharmaceutical solid-phase modules for constructing aptamer-drug conjugates	45
Dihydroartemisinin suppresses metastatic potential and induces apoptosis in gastric adenocarcinoma: An integrative experimental and computational analysis revealing inhibition of MMP14 and promotion o	45