Vox Sanguinis

Article	Citations
Collecting and evaluating convalescent plasma for COVID‐19 treatment: why and how?	110
ABO blood group and COVID‐19: a review on behalf of the ISBT COVID‐19 Working Group	103
Impact of COVID‐19 on blood centres in Zhejiang province China	102
Inactivation of severe acute respiratory syndrome coronavirus 2 in plasma and platelet products using a riboflavin and ultraviolet light‐based photochemical treatment	84
Post‐donation COVID‐19 identification in blood donors	71
Points to consider in the preparation and transfusion of COVID‐19 convalescent plasma	58
Guidance for the procurement of COVID‐19 convalescent plasma: differences between high‐ and low‐middle‐income countries	39
The impact of the SARS‐CoV‐2 outbreak on the safety and availability of blood transfusions in Italy	39
Coronavirus disease 2019 (COVID‐19) and decrease in blood donation: experience of Iranian Blood Transfusion Organization (IBTO)	38
Impact of the COVID‐19 pandemic on blood supply and demand in the WHO African Region	37
Operational protocol for donation of anti‐COVID‐19 convalescent plasma in Italy	34
Blood group ABO polymorphism inhibits SARS‐CoV‐2 infection and affects COVID‐19 progression	29
Blood donation in times of crisis: Early insight into the impact of COVID‐19 on blood donors and their motivation to donate across European countries	29
Pivotal role of convalescent plasma in managing emerging infectious diseases	27
Neonatal red blood cell transfusion	26
The risk to future pregnancies of transfusing Rh(D)‐negative females of childbearing potential with Rh(D)‐positive red blood cells during trauma resuscitation is dependent on their age at transfusion	26
Clinical use of Convalescent Plasma in the COVID‐19 pandemic: a transfusion‐focussed gap analysis with recommendations for future research priorities	26
Early experience with convalescent plasma as immunotherapy for COVID‐19 in China: Knowns and unknowns	26
COVID‐19 convalescent plasma therapy: hit fast, hit hard!	21
Use of COVID‐19 convalescent plasma in low‐ and middle‐income countries: a call for ethical principles and the assurance of quality and safety	20
Understanding the role of therapeutic plasma exchange in COVID‐19: preliminary guidance and practices	20
Research initiatives of blood services worldwide in response to the covid‐19 pandemic	20
Washed red cells: theory and practice	20
The protective effect of O blood type against SARS‐CoV‐2 infection	19
ABO blood group and SARS‐CoV‐2 antibody response in a convalescent donor population	19

Blood supply management in times of SARS‐CoV‐2 pandemic – challenges, strategies adopted, and the lessons learned from the experience of a hospital‐based blood centre	18
Amotosalen and ultraviolet A light treatment efficiently inactivates severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in human plasma	18
Severe acute respiratory syndrome coronavirus‐2: implications for blood safety and sufficiency	18
Blood donation and the global COVID‐19 pandemic: areas for social science research	17
Non‐phthalate plasticizer DEHT preserves adequate blood component quality during storage in PVC blood bags	16
Evaluation of SARS‐CoV‐2 antibody titers and potency for convalescent plasma donation: a brief commentary	16
Risk of future haemolytic disease of the fetus and newborn following the transfusion of Rh(D)‐positive blood products to Rh(D)‐negative children	15
Lack of association between ABO blood groups and susceptibility to SARS‐CoV‐2 infection	15
Pro‐inflammatory effects after platelet transfusion: a review	15
International Society of Blood Transfusion survey of experiences of blood banks and transfusion services during the COVID‐19 pandemic	15
Effect of HIV pre‐exposure prophylaxis (PrEP) on detection of early infection and its impact on the appropriate post‐PrEP deferral period	15
Viscoelastometric versus standard coagulation tests to guide periprocedural transfusion in adults with cirrhosis: A meta‐analysis of randomized controlled trials	15
Blood transfusions in mass casualty events: recent trends	14
Re‐introducing whole blood for transfusion: considerations for blood providers	13
Blood supply sufficiency and safety management in Iran during the COVID‐19 outbreak	12
A pilot randomized clinical trial of cryopreserved versus liquid‐stored platelet transfusion for bleeding in cardiac surgery: The cryopreserved versus liquid platelet‐New Zealand pilot tria	12
Complications of blood donation reported to haemovigilance systems: analysis of eleven years of international surveillance	12
Estimating the risks of prehospital transfusion of D‐positive whole blood to trauma patients who are bleeding in England	12
Blood donation by men who have sex with men: using evidence to change policy	11
HIV incidence in South African blood donors from 2012 to 2016: a comparison of estimation methods	11
Exchange transfusions in severe Rh‐mediated alloimmune haemolytic disease of the foetus and newborn: a 20‐year overview on the incidence, associated risks and outcome	11
Impact of pathogen reduction methods on immunological properties of the COVID‐19 convalescent plasma	11
Motivation, blood donor satisfaction and intention to return during the COVID‐19 pandemic	11
Assessing the inactivation capabilities of two commercially available platelet component pathogen inactivation systems: effectiveness at end of shelf life	10
Prevalence and risks of hepatitis E virus infection in blood donors from the Western Cape, South Africa	10
Clinical outcomes of cardiac surgery patients undergoing therapeutic plasma exchange for heparin‐induced thrombocytopenia	10
Vox Sanguinis International Forum on transfusion services' response to COVID‐19: Summary	10
Red‐blood‐cell alloimmunization and prophylactic antigen matching for transfusion in patients with warm autoantibodies	10
Iron deficiency among French whole‐blood donors: first assessment and identification of predictive factors	9
The international experience of bacterial screen testing of platelet components with automated microbial detection systems: An update	9
Preservation of neutralizing antibody function in COVID‐19 convalescent plasma treated using a riboflavin and ultraviolet light‐based pathogen reduction technology	9
Gender‐neutral donor deferral policies: experience in Argentina implementing individual risk‐assessment policies	9
Anti‐A and SARS‐CoV‐2: an intriguing association	9
Trends in blood donations, blood donors’ knowledge, practices and expectations during the COVID‐19 pandemic in Cameroon	9
Trends in platelet distributions from 2008 to 2017: a survey of twelve national and regional blood collectors	9
International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Basel and three virtual business meetings: Update on blood group systems	9
Clinical consequences of the extremely rare anti‐PP1Pk isoantibodies in pregnancy: a case series and review of the literature	8
The impact of COVID‐19 outbreak on the Transfusion Medicine Unit of a Northern Italy Hospital and Cancer Centre	8
The relationship of membrane stiffness, cytoskeleton structure and storage time of pRBCs	8
Residual risks of bacterial contamination for pathogen‐reduced platelet components	8
Colloid osmotic pressure of contemporary and novel transfusion products	8
Prediction and impact of personalized donation intervals	8
Activity‐based cost of platelet transfusions in medical and surgical inpatients at a US hospital	8
Incidence of anti‐D alloimmunization in D‐negative individuals receiving D‐positive red blood cell transfusion: A systematic review and meta‐analysis	8
Whole blood haemostatic function throughout a 28‐day cold storage period: an in vitro study	8
Lessons learned in the collection of convalescent plasma during the COVID‐19 pandemic	8
A discrete‐event simulation model for analysing and improving operations in a blood donation centre	8
Offering new and returned donors the option to give plasma: implications for donor retention and donor adverse events	8
10‐year analysis of human immunodeficiency virus incidence in first‐time and repeat donors in Brazil	8
Impact of disasters on blood donation rates and blood safety: A systematic review and meta‐analysis	7

Physician autonomy and patient rights: lessons from an enforced blood transfusion and the role of patient blood management	7
Survey of blood centre readiness regarding removal of DEHP from blood bag sets: The BEST Collaborative Study	7
Early packed red blood cell transfusion in major trauma patients: Evaluation and comparison of different prediction scores for massive transfusion	7
ISBT 2022 ‐ Abstract Book	7
Establishment of transfusion‐relevant bacteria reference strains for red blood cells	7
Are convalescent plasma stocks collected during former COVID‐19 waves still effective against current SARS‐CoV‐2 variants?	7
Impact of COVID‐19 on blood donor deferral patterns during the COVID‐19 pandemic: A retrospective analysis	7
Deferasirox‐associated Fanconi syndrome in adult patients with transfusional iron overload	7
Stepwise access to safe plasma proteins in resource‐constrained countries: Local production and pathways to fractionation—Report of an International Society of Blood Transfusion Workshop	7
Association of the ABO blood group with SARS‐CoV‐2 infection in a community with low infection rate	7
HLA Class II regulation of immune response in sickle cell disease patients: Susceptibility to red blood cell alloimmunization (systematic review and meta‐analysis)	7
International Forum on Policies and Practice for Transfusion of ABO and RhD Non‐Identical Platelets: Summary	7
Automated RBC Exchange has a greater effect on whole blood viscosity than manual whole blood exchange in adult patients with sickle cell disease	7
Abstract	7
HIV residual risk in Canada for apheresis source plasma donation without deferral for men who have sex with men	7
Sequence variants in the proximal promoter and +5.8‐kb site of ABO in Koreans with weak B phenotypes	6
Risk of variant Creutzfeldt–Jakob disease transmission by blood transfusion in Australia	6
The impact of donor ferritin testing on blood availability in Canada	6
Use of plerixafor to mobilize haematopoietic progenitor cells in healthy donors	6
Reducing the red blood cell transfusion threshold from 8·0 g/dl to 7·0 g/dl in acute myeloid leukaemia patients undergoing induction chemotherapy reduces transfusion rates without adversely affecting	6
A case of Philadelphia chromosome‐positive acute lymphocytic leukaemia with type I CD36 deficiency	6
International survey of strategies to mitigate transfusion‐transmittedTrypanosoma cruzi in non‐endemic countries, 2016–2018	6
Plasma procurement and plasma product safety in light of the COVID‐19 pandemic from the perspective of the plasma industry	6
Noncompliance to blood donor selection criteria by men who have sex with men – Complidon 2017, France	6
Impact of long‐term storage of plasma and cell‐free DNA on measured DNA quantity and fetal fraction	6
Preventing transfusion‐transmitted malaria in France	6
Blood transfusion activity in a general hospital during the COVID‐19 pandemic	6
Vox Sanguinis International Forum on Donor Incentives: Summary	6
Recommendation for validation and quality assurance of non‐invasive prenatal testing for foetal blood groups and implications for IVD risk classification according to EU regulati	6
Abstract	6
Current challenges of severe acute respiratory syndrome coronavirus 2 seroprevalence studies among blood donors: A scoping review	6
Introduction of principles of blood management to healthy donor bone marrow harvesting	5
COVID‐19 convalescent plasma: Evolving strategies for serological screening in France	5
Understanding the experiences of plasma donors in Canada's new source plasma collection centres during COVID‐19: A qualitative study	5
An open‐source python library for detection of known and novel Kell, Duffy and Kidd variants from exome sequencing	5
Determinants of the intention to participate in a programme of plasma donation for fractionation among men who have sex with men	5
Venous sample is superior to repeated skin‐prick testing in blood donor haemoglobin second‐line screening	5
Patterns of red‐cell transfusion use in obstetric practice in Sweden 2003‐2017: A nationwide study	5
How donor selection criteria can be evaluated with limited scientific evidence: lessons learned from the TRANSPOSE project	5
Civilian prehospital transfusion – experiences from a French region	5
Current status of rapid bacterial detection methods for platelet components: A 20‐year review by the ISBT Transfusion‐Transmitted Infectious Diseases Working Party Subgroup on Bacteria	5
Qualifying coronavirus disease 2019 convalescent plasma donors in Israel	5
Overcoming the challenges of interpreting complex and uncommon RH alleles from whole genomes	5
International Forum on the Management of Major Haemorrhage: Summary	5
High‐titre anti‐SARS‐CoV‐2 convalescent plasma donation after donors’ vaccination	5
Amlodipine as adjuvant therapy to current chelating agents for reducing iron overload in thalassaemia major: a systematic review, meta‐analysis and simulation of future studies	5
A novel cancer immunotherapy utilizing autologous tumour tissue	5
Determinants of intention to return to donate blood among first‐time blood donors in Ghana	5
Filariasis and transfusion‐associated risk: a literature review	5
Blood donor eligibility criteria for medical conditions: A BEST collaborative study	5
Impacts of COVID‐19 and elective surgery cancellations on platelet supply and utilization in the Canadian Province of British Columbia	5
Does ABO blood group influence antibody response to SARS‐CoV‐2 vaccination?	5
Hepatitis E virus is effectively inactivated in platelet concentrates by ultraviolet C light	5
Lipid ratios as a marker for red blood cell storage quality and as a possible explanation for donor gender differences in storage quality	5
Time–temperature indicators versus temperature indicators for transfusion practice: Application in the real hospital setting	5
First annual report of Chinese haemovigilance network	5
RAGE interacts with the necroptotic protein RIPK3 and mediates transfusion‐induced danger signal release	5
An international comparison of anti‐SARS‐COV‐2 assays used for seroprevalence surveys from blood component providers	5
Validation of a flow‐cytometry‐based red blood cell antigen phenotyping method	5
Polycythaemia vera: molecular genetics, diagnostics and therapeutics	5
An international comparison of HIV prevalence and incidence in blood donors and general population: a BEST Collaborative study	4
Immediate intravenous iron administration improves anaemia recovery following total knee arthroplasty: A propensity‐matched analysis	4
Platelet transfusion is associated with 90‐day and 1‐year mortality for adult patients requiring veno‐arterial extracorporeal membrane oxygenation	4
Efficacy of therapeutic plasma exchange in severe COVID‐19 disease: A meta‐analysis	4
Management of blood transfusion services in low‐resource countries	4
The new donor vigilance system in Denmark reveals regional differences in adverse reactions supposedly caused by variation in the registration	4
Demand and usage of unrelated donor products for allogeneic haematopoietic cell transplantation during the COVID‐19 pandemic: A Canadian Blood Services Stem Cell Registry analysis	4
Preventing alloimmunization using a new model for matching extensively typed red blood cells	4
Effects of plasmapheresis frequency on health status and exercise performance in men: A randomized controlled trial	4
International Forum on Gender Identification and Blood Collection: Summary	4
Use of O RhD‐negative red blood cells: A nationwide, prospective audit	4
Clinical and in vitro evaluation of red blood cells collected and stored in a non‐DEHP plasticized bag system	4
White paper on pandemic preparedness in the blood supply	4
Reduced neutralizing antibody potency of COVID‐19 convalescent vaccinated plasma against SARS‐CoV‐2 Omicron variant	4
Analysis of gender representation on transfusion medicine journal editorial boards: Comparison between 2019 and 2022	4
Plasma collection and supply in Europe: Proceedings of an International Plasma and Fractionation Association and European Blood Alliance symposium	4
In vitro diagnostics for screening the blood supply: the new European regulation for IVD and the WHO IVD prequalification programme	4
Genetic determinants of ferritin, haemoglobin levels and haemoglobin trajectories: results from Donor InSight	4
The incremental benefit of anaerobic culture for controlling bacterial risk in platelets: a systematic review and meta‐analysis	4
Characterization of health issues in young first‐time blood donors	4

Inequality averse and compassionate blood donor: implication for interventions	4
GMP‐grade CD34+ selection from HLA‐homozygous licensed cord blood units and short‐term expansion under European ATMP regulations	4
Early and out‐of‐hospital use of COVID‐19 convalescent plasma: An international assessment of utilization and feasibility	4
Single‐exon approach to non‐invasive fetal RHD screening in early pregnancy: An update after 10 years' experience	4
High false discovery rate of the Architect anti‐HCV screening test in blood donors in Uganda and evaluation of an algorithm for confirmatory testing	4
Preference for whole blood versus plasma donation among university students	4
Development and evaluation of stem cell collection procedure diagrams to support the education and recruitment of committed stem cell donors	4
Validation of a standardized donor health questionnaire across substances of human origin	4
Short‐term high‐dose intravenous iron reduced peri‐operative transfusion after staggered bilateral total knee arthroplasty: A retrospective cohort study	4
Maternity iron, anaemia and blood management in South Australia: a practice‐based evidence for clinical practice improvement	4
The spectrum of ABO haemolytic disease of the fetus and newborn in neonates born to group O mothers	4
Cryopreserved platelets and their suitability in being re‐suspended in additive solution	4
Red blood cell alloimmunization among recipients of blood transfusion in India: A systematic review and meta‐analysis	4
International Forum on the Collection and Use of COVID‐19 Convalescent Plasma: Protocols, Challenges and Lessons Learned: Summary	4
Safety profile of plasma for fractionation donated in the United Kingdom, with respect to variant Creutzfeldt–Jakob disease	4
Rapid genotyping of 508G>A (rs3745635) and 1067T>A (rs3894326) of FUT3 by a duplex Eprobe‐mediated melting curve analysis	4
Use of selective phenotyping and genotyping to identify rare blood donors in Canada	4
Breast milk contains red cell isohaemagglutinins: An observational study of 176 mothers	4
Recommendations for in vitro evaluation of blood components collected, prepared and stored in non‐DEHP medical devices	4
Costs associated with transfusion therapy in patients with myelodysplastic syndromes in Sweden: a nationwide retrospective cohort study	4
ABO haemolytic disease of the newborn: Improved prediction by novel integration of causative and protective factors in newborn and mother	4
Serum anti‐Spike immunoglobulin G levels in random blood donors in Italy: High‐titre convalescent plasma is easier than ever to procure	3
Impact of donor ferritin testing on iron deficiency prevention and blood availability in France: A cohort simulation study	3
Plasma, platelet and red blood cell transfusion ratios for life‐threatening non‐traumatic haemorrhage in medical and post‐surgical patients: An observational study	3
Eye drops of human origin—Current status and future needs: Report on the workshop organized by the ISBT Working Party for Cellular Therapies	3
The ‘rejuvenating factor’ TIMP‐2 is detectable in human blood components for transfusion	3
DEHT is a suitable plasticizer option for phthalate‐free storage of irradiated red blood cells	3
The history of buffy coat platelet concentrates: The Dutch story	3
Weak D type 42: Antigen density and risk of alloimmunization in the province of Québec	3
The impact of revised definitions for transfusion‐associated circulatory overload and transfusion‐related acute lung injury on haemovigilance reporting	3
Frequency and timing of all‐cause deaths in visits involving suspected transfusion reactions, and the significance of cardiopulmonary disturbances	3
A comparison of the effect of X and gamma irradiation on red cell storage quality	3
Utility of reticulocyte haemoglobin content and immature reticulocyte fraction in early diagnosis of latent iron deficiency in whole blood donors	3
A branded bandage is worth a thousand words: blood branded bandages signal men’s generosity and morality	3
Reported non‐compliance with pre‐donation screening among blood donors in Québec, Canada: A focus on the 3‐month deferral for men who have sex with men	3
Mortality and outcomes by blood group in trauma patients: A systematic review and meta‐analysis	3
Challenging the 30‐min rule for thawed plasma	3
Efficacy and safety of a reduced dose of plerixafor in combination with granulocyte colony‐stimulating factor in healthy haploidentical stem cell donors	3
Gone, but haven't forgotten: insights on plasmapheresis donation from lapsed donors	3
Profile of the single‐use, multiple‐pass protein A adsorber column in immunoadsorption	3
Transfusion profile, clinical characteristics, comorbidities and outcomes of 3014 hospitalized patients diagnosed with COVID‐19 in Brazil	3
Effect of red blood cell transfusion on inflammation, endothelial cell activation and coagulation in the critically ill	3
A randomized study of a best practice alert for platelet transfusions	3
Research partnerships between blood services and public health authorities: An international, cross‐sectional survey	3
Ludwik Hirszfeld: A pioneer of transfusion and immunology during the world wars and beyond	3
Subjects with blood group O are not at lower risk to acquire SARS‐CoV‐2 infection	3
Low ferritin levels appear to be associated with worsened health in male repeat blood donors	3
Is intravenous immunoglobulin a risk factor for necrotizing enterocolitis in neonates with haemolytic disease of the newborn? A retrospective cohort study	3
Application of unsupervised machine learning to identify areas of blood product wastage in transfusion medicine	3
TACO‐BEL‐3: a feasibility study and a retrospective audit of diuretics for patients receiving blood transfusion at ten hospitals	3
Dose‐dependent effects of red blood cell transfusion and case mix index on venous thromboembolic events in spine surgery	3
Blood component ratios in children with non‐traumatic life‐threatening bleeding	3
Optimization of diagnostic strategy for non‐invasive cell‐free foetal RHD determination from maternal plasma	3
Vox Sanguinis International Forum on the selection and preparation of blood components for intrauterine transfusion: Summary	3
Is there an optimal trade‐off between anaemia and red blood cell transfusion in surgical critically ill patients after oncologic surgery?	3
Explainable haemoglobin deferral predictions using machine learning models: Interpretation and consequences for the blood supply	3
Invitro phagocytosis of liquid‐stored red blood cells requires serum and can be inhibited with fucoidan and dextran sulphate	3
International Forum on Home‐Based Blood Transfusion: Summary	3
COVID‐19 infection and complications according to ABO blood group in the elderly: A population‐based subcohort and meta‐analysis	3
Impact of restrictive red blood cell transfusion strategy on thrombosis‐related events: A meta‐analysis and systematic review	3
Low‐dose prophylaxis and its impact on the health of haemophilia patients	3
MATRA‐A: A study on massive transfusion	3
Plasma resuscitation improves and restores intestinal microcirculatory physiology following haemorrhagic shock	3
Vox Sanguinis International forum on the selection and preparation of blood components for intrauterine transfusion	3
Putting the spotlight on donation‐related risks and donor safety – are we succeeding in protecting donors?	3
Basophil activation test for allergic and febrile non‐haemolytic transfusion reactions among paediatric patients with haematological or oncological disease	3
Evaluation of the Sysmex XN‐31 automated analyser for blood donor malaria screening at Malawi Blood Transfusion Services	3
Pharmacogenomics with red cells: a model to study protein variants of drug transporter genes	3
A survey of laboratory biosafety and protective measures in blood transfusion departments during the COVID‐19 pandemic	2
Adverse events caused by cord blood infusion in Japan during a 5‐year period	2
A review of electronic medical records and safe transfusion practice for guideline development	2
Factors affecting need for blood transfusion in paediatric patients undergoing open surgery for hip dysplasia	2
Platelet transfusions in haematologic malignancies in the last six months of life	2
Compliance and attitudes of blood donors following transitioning from permanent to 12‐month deferral of men who have sex with men in Hong Kong	2
Risk of a blood donation contaminated with hepatitis E virus entering the blood supply before the implementation of universal RNA screening in France	2
The immune potential of ex vivo stored platelets: a review	2
West Nile virus and blood transfusion safety: A European perspective	2
The interaction between Glycophorin A (GPA) and Band 3 in the formation of the Wright b (Wrb) antigen	2
Daratumumab interference in flow cytometric anti‐granulocyte antibody testing can be overcome using non‐human blocking antibodies	2
Evolving the gay, bisexual and other men who have sex with men time‐based deferral to sexual risk screening for all donors: The contribution of Canadian research programmes	2
Syncopal‐type reactions tend to be delayed and result in falls among elderly blood donors	2
The use of the GeeniusTM HIV‐1/2 Rapid confirmatory test for the enrolment of patients and blood donors in the WHO Universal Test and Treat Strategy in Cameroon, Africa	2
Mechanism evaluation for an amino acid substitution p.Y246C of B‐glycosyltransferase enzyme with Bweak phenotype	2
Quality assessment and harmonization of laboratories across Europe for multiple SARS‐CoV‐2 serology assays	2
Altered strategy of prophylactic anti‐D administration in pregnancy to cover term and post‐term – a pilot study	2
International Forum on Gender Identification and Blood Collection: Responses	2
An unusual variant glycophorin expressing protease‐resistant M antigen encoded by the GYPB‐E(2‐4)‐B hybrid gene	2
Changes to hepatic tissue oxygenation, abdominal perfusion and its association with enteral feeding with liberal transfusion threshold in anaemic preterm infants: A prospective cohort study.	2
Removing hepatitis C antibody testing for Australian blood donations: A cost‐effectiveness analysis	2
Therapeutic granulocyte infusion for patients with severe neutropaenia and neutrophilic dysfunction: New Zealand experience	2
Secretor status of blood group O mothers is associated with development of ABO haemolytic disease in the newborn	2
Modelling the outcomes of different red blood cell transfusion strategies for the treatment of traumatic haemorrhage in the prehospital setting in the United Kingdom	2
Elimination of pretransfusion RhD typing at Mackay Memorial Hospital, Taiwan—30‐year experience (1988–2017)	2
Non‐severe allergic transfusion reaction: A hidden cause of wastage of blood product and laboratory resources	2
Association between leukoreduced red blood cell transfusions and hospital‐acquired infections in critically ill children: A secondary analysis of the TRIPICU study	2