Toxicology and Applied Pharmacology

Papers
(The TQCC of Toxicology and Applied Pharmacology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-02-01 to 2024-02-01.)
ArticleCitations
Antimony and its compounds: Health impacts related to pulmonary toxicity, cancer, and genotoxicity61
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways60
p38 MAPK-DRP1 signaling is involved in mitochondrial dysfunction and cell death in mutant A53T α-synuclein model of Parkinson's disease54
Arsenic-induced changes in miRNA expression in cancer and other diseases51
Exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood disrupts hormones and ovarian folliculogenesis throughout the prime reproductive life of the mouse48
miR-187-5p/apaf-1 axis was involved in oxidative stress-mediated apoptosis caused by ammonia via mitochondrial pathway in chicken livers48
Octreotide and melatonin alleviate inflammasome-induced pyroptosis through inhibition of TLR4-NF-κB-NLRP3 pathway in hepatic ischemia/reperfusion injury46
Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis45
Melatonin alleviates doxorubicin-induced mitochondrial oxidative damage and ferroptosis in cardiomyocytes by regulating YAP expression38
Exposure to low doses of inorganic arsenic induces transgenerational changes on behavioral and epigenetic markers in zebrafish (Danio rerio)37
Gambogenic acid induces ferroptosis in melanoma cells undergoing epithelial-to-mesenchymal transition37
In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen recept36
The effects of a phthalate metabolite mixture on antral follicle growth and sex steroid synthesis in mice36
The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat35
Reducing the antigen-independent toxicity of antibody-drug conjugates by minimizing their non-specific clearance through PEGylation34
Delivery of oxaliplatin to colorectal cancer cells by folate-targeted UiO-66-NH234
Induction of apoptosis in breast cancer cells by naphthylisoquinoline alkaloids34
Vildagliptin, a DPP-4 inhibitor, attenuates carbon tetrachloride-induced liver fibrosis by targeting ERK1/2, p38α, and NF-κB signaling33
4-methylpyrazole protects against acetaminophen-induced acute kidney injury31
Berberine attenuates severity of chronic pancreatitis and fibrosis via AMPK-mediated inhibition of TGF-β1/Smad signaling and M2 polarization29
Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction29
Perfluorooctanesulfonic acid (PFOS) administration shifts the hepatic proteome and augments dietary outcomes related to hepatic steatosis in mice29
Celastrol augments sensitivity of NLRP3 to CP-456773 by modulating HSP-90 and inducing autophagy in dextran sodium sulphate-induced colitis in rats28
Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis28
Effects of an environmentally relevant PFAS mixture on dopamine and steroid hormone levels in exposed mice28
Chronic acrylamide exposure induced glia cell activation, NLRP3 infl-ammasome upregulation and cognitive impairment27
Balance between the toxicity and anticancer activity of arsenic trioxide in treatment of acute promyelocytic leukemia27
Honokiol: A polyphenol neolignan ameliorates pulmonary fibrosis by inhibiting TGF-β/Smad signaling, matrix proteins and IL-6/CD44/STAT3 axis both in vitro and in vivo27
TGF-β1-induced EMT activation via both Smad-dependent and MAPK signaling pathways in Cu-induced pulmonary fibrosis27
Implications for prenatal cadmium exposure and adverse health outcomes in adulthood27
Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis26
Cadmium induced inflammation and apoptosis of porcine epididymis via activating RAF1/MEK/ERK and NF-κB pathways26
Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuro26
(−)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD25
Natural products in the reprogramming of cancer epigenetics25
Targeting autophagy by natural product Ursolic acid for prevention and treatment of osteoporosis25
Molecular and clinical insights of matrix metalloproteinases into cancer spread and potential therapeutic interventions25
Irisin lowers blood pressure by activating the Nrf2 signaling pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats25
A transcriptomic overview of lung and liver changes one day after pulmonary exposure to graphene and graphene oxide25
Cyanidin prevents the hyperproliferative potential of fibroblast-like synoviocytes and disease progression via targeting IL-17A cytokine signalling in rheumatoid arthritis24
Organophosphate ester tri-o-cresyl phosphate interacts with estrogen receptor α in MCF-7 breast cancer cells promoting cancer growth24
Montelukast ameliorates Concanavalin A-induced autoimmune hepatitis in mice via inhibiting TNF-α/JNK signaling pathway24
Endocrine-disrupting chemicals rapidly affect intercellular signaling in Leydig cells24
Low dose spironolactone-mediated androgen-adiponectin modulation alleviates endocrine-metabolic disturbances in letrozole-induced PCOS24
Health disparities: Intracellular consequences of social determinants of health24
Arsenic-protein interactions as a mechanism of arsenic toxicity24
Arsenic-induced lung inflammation and fibrosis in a rat model: Contribution of the HMGB1/RAGE, PI3K/AKT, and TGF-β1/SMAD pathways24
Resveratrol protects against PM2.5-induced heart defects in zebrafish embryos as an antioxidant rather than as an AHR antagonist24
A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm23
Role of long non-coding RNAs and MYC interaction in cancer metastasis: A possible target for therapeutic intervention23
Benzyl isothiocyanate ameliorates high-fat/cholesterol/cholic acid diet-induced nonalcoholic steatohepatitis through inhibiting cholesterol crystal-activated NLRP3 inflammasome in Kupffer cells23
Exposures to uranium and arsenic alter intraepithelial and innate immune cells in the small intestine of male and female mice23
Calcitriol ameliorated autonomic dysfunction and hypertension by down-regulating inflammation and oxidative stress in the paraventricular nucleus of SHR22
Nitrofuran drugs beyond redox cycling: Evidence of Nitroreduction-independent cytotoxicity mechanism22
Sulforaphane inhibits blue light–induced inflammation and apoptosis by upregulating the SIRT1/PGC-1α/Nrf2 pathway and autophagy in retinal pigment epithelial cells22
Activation of the Erk/MAPK signaling pathway is a driver for cadmium induced prostate cancer22
Generating adverse outcome pathway (AOP) of inorganic arsenic-induced adult male reproductive impairment via integration of phenotypic analysis in comparative toxicogenomics database (CTD) and AOP wik22
Triptonide effectively suppresses gastric tumor growth and metastasis through inhibition of the oncogenic Notch1 and NF-κB signaling pathways22
Effects of environmental and occupational lead toxicity and its association with iron metabolism21
Leucovorin ameliorated methotrexate induced intestinal toxicity via modulation of the gut microbiota21
Ovatodiolide, isolated from Anisomeles indica, suppresses bladder carcinogenesis through suppression of mTOR/β-catenin/CDK6 and exosomal miR-21 derived from M2 tumor-associated macrophages21
Effects of lithium on cytokine neuro-inflammatory mediators, Wnt/β-catenin signaling and microglial activation in the hippocampus of chronic mild stress-exposed rats20
Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways20
Zebrafish early life stages as alternative model to study ‘designer drugs’: Concordance with mammals in response to opioids20
MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf219
Upregulation of ubiquitinated proteins and their degradation pathway in muscle atrophy induced by cisplatin in mice19
NLRC5 negatively regulates inflammatory responses in LPS-induced acute lung injury through NF-κB and p38 MAPK signal pathways19
Nano selenium protects against deltamethrin-induced reproductive toxicity in male rats19
Characterizing biopersistence potential of the metabolite 5:3 fluorotelomer carboxylic acid after repeated oral exposure to the 6:2 fluorotelomer alcohol19
Cognitive enhancing effect of diapocynin in D-galactose-ovariectomy-induced Alzheimer's-like disease in rats: Role of ERK, GSK-3β, and JNK signaling19
Comparative analysis of the physicochemical, toxicokinetic, and toxicological properties of ether-PFAS19
Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes19
Pulmonary toxicants and fibrosis: innate and adaptive immune mechanisms19
Cisplatin induces autophagy-associated apoptosis in human oral squamous cell carcinoma (OSCC) mediated in part through reactive oxygen species19
Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment19
Protective effect of resveratrol on obesity-related osteoarthritis via alleviating JAK2/STAT3 signaling pathway is independent of SOCS319
Low doses of BPA induced abnormal mitochondrial fission and hypertrophy in human embryonic stem cell-derived cardiomyocytes via the calcineurin-DRP1 signaling pathway: A comparison between XX and XY c19
Amentoflavone prevents ox-LDL-induced lipid accumulation by suppressing the PPARγ/CD36 signal pathway19
Ovarian mitochondrial and oxidative stress proteins are altered by glyphosate exposure in mice18
Improved bioavailability and anticancer efficacy of Hesperetin on breast cancer via a self-assembled rebaudioside A nanomicelles system18
Curcumin ameliorates hypertension via gut-brain communication in spontaneously hypertensive rat18
Prepubertal exposure to arsenic alters male reproductive parameters in pubertal and adult rats18
Minocycline prevents neuronal hyperexcitability and neuroinflammation in medial prefrontal cortex, as well as memory impairment caused by repeated toluene inhalation in adolescent rats18
Angiogenesis signaling in breast cancer models is induced by hexachlorobenzene and chlorpyrifos, pesticide ligands of the aryl hydrocarbon receptor18
Oxytetracycline induces anxiety-like behavior in adult zebrafish18
Multi and transgenerational epigenetic effects of di-(2-ethylhexyl) phthalate (DEHP) in liver18
Polyphyllin I reverses the resistance of osimertinib in non-small cell lung cancer cell through regulation of PI3K/Akt signaling17
Acute and chronic vascular effects of inhaled crotonaldehyde in mice: Role of TRPA117
Targeting lung cancer stem cells using combination of Tel and Docetaxel liposomes in 3D cultures and tumor xenografts17
The protective mechanism of resveratrol against hepatic injury induced by iron overload in mice17
Integrated transcriptomic and metabolomic analyses to characterize the anti-cancer effects of (−)-epigallocatechin-3-gallate in human colon cancer cells17
Chloroquine may induce endothelial injury through lysosomal dysfunction and oxidative stress17
Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells17
Suppression of iron mobilization from lysosomes to mitochondria attenuates liver injury after acetaminophen overdose in vivo in mice: Protection by minocycline17
Dual targeting of EZH2 and androgen receptor as a novel therapy for castration-resistant prostate cancer17
Lactobacillus rhamnosus GG combined with inosine ameliorates alcohol-induced liver injury through regulation of intestinal barrier and Treg/Th1 cells17
Targeting CD166+ lung cancer stem cells: Molecular study using murine dendritic cell vaccine17
Inorganic arsenic and its methylated metabolites as endocrine disruptors in the placenta: Mechanisms underpinning glucocorticoid receptor (GR) pathway perturbations17
Cardiac toxicity from bisphenol A exposure in human-induced pluripotent stem cell-derived cardiomyocytes17
Daphnetin ameliorates glucocorticoid-induced osteoporosis via activation of Wnt/GSK-3β/β-catenin signaling17
Oxymatrine ameliorates imiquimod-induced psoriasis pruritus and inflammation through inhibiting heat shock protein 90 and heat shock protein 60 expression in keratinocytes17
miR-148a/LDLR mediates hypercholesterolemia induced by prenatal dexamethasone exposure in male offspring rats17
Physalin A attenuates inflammation through down-regulating c-Jun NH2 kinase phosphorylation/Activator Protein 1 activation and up-regulating the antioxidant activity17
The interrupted cross-talk of inflammatory and oxidative stress trajectories signifies the effect of artesunate against hepatic ischemia/reperfusion-induced inflammasomopathy16
The selective c-Met inhibitor capmatinib offsets cisplatin-nephrotoxicity and doxorubicin-cardiotoxicity and improves their anticancer efficacies16
Irinotecan-mediated diarrhea is mainly correlated with intestinal exposure to SN-38: Critical role of gut Ugt16
Paris saponin II-induced paraptosis-associated cell death increased the sensitivity of cisplatin16
Exposure to alternative bisphenols BPS and BPF through breast milk: Noxious heritage effect during nursing associated with idiopathic infertility16
Network pharmacology and molecular docking analysis on molecular targets: Mechanisms of baicalin and baicalein against hyperuricemic nephropathy16
SPP1 derived from silica-exposed macrophage exosomes triggers fibroblast transdifferentiation16
Protective effect of EX-527 against high-fat diet-induced diabetic nephropathy in Zucker rats16
Metabolomic-based assessment reveals dysregulation of lipid profiles in human liver cells exposed to environmental obesogens16
Apigenin alleviates cancer drug Sorafenib induced multiple toxic effects in Swiss albino mice via anti-oxidative stress16
Diosgenin alleviates hypercholesterolemia via SRB1/CES-1/CYP7A1/FXR pathway in high-fat diet-fed rats16
T helper 2-driven immune dysfunction in chronic arsenic-exposed individuals and its link to the features of allergic asthma16
A toxicogenomic approach for the risk assessment of the food contaminant acetamide16
Arsenic induced redox imbalance triggers the unfolded protein response in the liver of zebrafish16
C-myc promotes miR-92a-2-5p transcription in rat ovarian granulosa cells after cadmium exposure16
Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil16
NURA: A curated dataset of nuclear receptor modulators16
Hydrogen sulfide attenuates postoperative cognitive dysfunction through promoting the pathway of Warburg effect-synaptic plasticity in hippocampus16
Food emulsifier polysorbate 80 promotes the intestinal absorption of mono-2-ethylhexyl phthalate by disturbing intestinal barrier16
Ligustilide inhibits the proliferation of non-small cell lung cancer via glycolytic metabolism15
Synergistic action of organophosphates and COVID-19 on inflammation, oxidative stress, and renin-angiotensin system can amplify the risk of cardiovascular maladies15
Thymol activates TRPM8-mediated Ca2+ influx for its antipruritic effects and alleviates inflammatory response in Imiquimod-induced mice15
Leukocyte apoptosis, TNF-α concentration and oxidative damage in lead-exposed workers15
Gliclazide attenuates acetic acid-induced colitis via the modulation of PPARγ, NF-κB and MAPK signaling pathways15
Dexamethasone inhibits pancreatic tumor growth in preclinical models: Involvement of activating glucocorticoid receptor15
Diosmin ameliorates inflammation, insulin resistance, and fibrosis in an experimental model of non-alcoholic steatohepatitis in rats15
Molecular docking analyses of Escin as regards cyclophosphamide-induced cardiotoxicity: In vivo and in Silico studies15
Remdesivir; molecular and functional measures of mitochondrial safety15
Astaxanthin attenuates alcoholic cardiomyopathy via inhibition of endoplasmic reticulum stress-mediated cardiac apoptosis15
Casticin inhibits stemness of hepatocellular carcinoma cells via disrupting the reciprocal negative regulation between DNMT1 and miR-148a-3p15
A systematic review of clinical and laboratory findings of lead poisoning: lessons from case reports15
Safety assessment of drug combinations used in COVID-19 treatment: in silico toxicogenomic data-mining approach15
A network pharmacology approach to investigate the anticancer mechanism of cinobufagin against hepatocellular carcinoma via downregulation of EGFR-CDK2 signaling15
Ozone-induced changes in oxidative stress parameters in brain regions of adult, middle-age, and senescent Brown Norway rats15
The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice15
Arsenic trioxide-induced p38 MAPK and Akt mediated MCL1 downregulation causes apoptosis of BCR-ABL1-positive leukemia cells15
Thyroid disruption and developmental toxicity caused by triphenyltin (TPT) in zebrafish embryos/larvae15
Crocin induces ROS-mediated papillary thyroid cancer cell apoptosis by modulating the miR-34a-5p/PTPN4 axis in vitro14
Breast cancer cells-derived Von Willebrand Factor promotes VEGF-A-related angiogenesis through PI3K/Akt-miR-205-5p signaling pathway14
Linagliptin ameliorates acetic acid-induced colitis via modulating AMPK/SIRT1/PGC-1α and JAK2/STAT3 signaling pathway in rats14
Ethyl maltol enhances copper mediated cytotoxicity in lung epithelial cells14
Effects of silver nanoparticles on T98G human glioblastoma cells14
Co-exposure to PCB126 and PFOS increases biomarkers associated with cardiovascular disease risk and liver injury in mice14
Chronic arsenic exposure enhances metastatic potential via NRF2-mediated upregulation of SOX914
HepG2 (C3A) spheroids show higher sensitivity compared to HepaRG spheroids for drug-induced liver injury (DILI)14
Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/β-catenin, AMPK/mTOR signaling pathways14
Development of quercetin-loaded PVCL–PVA–PEG micelles and application in inhibiting tumor angiogenesis through the PI3K/Akt/VEGF pathway14
Natural alkaloid 8-oxo-epiberberine inhibited TGF-β1-triggred epithelial-mesenchymal transition by interfering Smad314
A QSAR study that compares the ability of bisdioxopiperazine analogs of the doxorubicin cardioprotective agent dexrazoxane (ICRF-187) to protect myocytes with DNA topoisomerase II inhibition14
Biological effects of inhaled hydraulic fracturing sand dust. III. Cytotoxicity and pro-inflammatory responses in cultured murine macrophage cells14
Bisphenolic compounds alter gene expression in MCF-7 cells through interaction with estrogen receptor α14
Isorhynchophylline ameliorates paraquat-induced acute kidney injury by attenuating oxidative stress and mitochondrial damage via regulating toll-interacting expression14
Role of the PI3K/Akt pathway in cadmium induced malignant transformation of normal prostate epithelial cells13
Curcumin alleviates arsenic-induced injury in duck skeletal muscle via regulating the PINK1/Parkin pathway and protecting mitochondrial function13
Gut microbiome in neuroendocrine and neuroimmune interactions: The case of genistein13
Hesperetin protects against palmitate-induced cellular toxicity via induction of GRP78 in hepatocytes13
Low dose lead exposure at the onset of puberty disrupts spermatogenesis-related gene expression and causes abnormal spermatogenesis in mouse13
Preclinical toxicology profile of squalene epoxidase inhibitors13
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats13
Gut microbiome-host interactions in driving environmental pollutant trichloroethene-mediated autoimmunity13
Melatonin's efficacy in stroke patients; a matter of dose? A systematic review13
Comparative physiology and efficacy of atropine and scopolamine in sarin nerve agent poisoning13
U0126 pretreatment inhibits cisplatin-induced apoptosis and autophagy in HEI-OC1 cells and cochlear hair cells13
Resveratrol and its nanocrystals: A promising approach for cancer therapy?13
Orlistat delays hepatocarcinogenesis in mice with hepatic co-activation of AKT and c-Met13
Toxicity analysis of endocrine disrupting pesticides on non-target organisms: A critical analysis on toxicity mechanisms13
Resveratrol ameliorates lipopolysaccharide-induced anxiety-like behavior by attenuating YAP-mediated neuro-inflammation and promoting hippocampal autophagy in mice13
CoQ10 protects against acetaminophen-induced liver injury by enhancing mitophagy13
S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs13
Andrographolide inhibits IL-1β release in bone marrow-derived macrophages and monocyte infiltration in mouse knee joints induced by monosodium urate13
Pharmacological postconditioning with sappanone A ameliorates myocardial ischemia reperfusion injury and mitochondrial dysfunction via AMPK-mediated mitochondrial quality control13
Ononin alleviates endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity by activating SIRT313
Astrocytic Kir4.1 regulates NMDAR/calpain signaling axis in lipopolysaccharide-induced depression-like behaviors in mice13
Chronic cannabidiol treatment reduces the carbachol-induced coronary constriction and left ventricular cardiomyocyte width of the isolated hypertensive rat heart12
Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway12
Biological effects of inhaled hydraulic fracturing sand dust. VIII. Immunotoxicity12
Maternal-fetal disposition of domoic acid following repeated oral dosing during pregnancy in nonhuman primate12
Final results from a 90-day quantitative inhalation toxicology study evaluating the dose-response and fate in the lung and pleura of chrysotile-containing brake dust compared to TiO2, chrysotile, croc12
The circadian clock protects against acute radiation-induced dermatitis12
MiR-122-5p increases radiosensitivity and aggravates radiation-induced rectal injury through CCAR112
Effect of dexamethasone treatment at variable therapeutic windows in reversing nitrogen mustard-induced corneal injuries in rabbit ocular in vivo model12
Apple polyphenol phloretin complexed with ruthenium is capable of reprogramming the breast cancer microenvironment through modulation of PI3K/Akt/mTOR/VEGF pathways12
PCC0208023, a potent SHP2 allosteric inhibitor, imparts an antitumor effect against KRAS mutant colorectal cancer12
Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress12
Down-regulation of lncRNA MEG3 promotes chronic low dose cadmium exposure-induced cell transformation and cancer stem cell-like property12
Involvement of endoplasmic reticulum stress-activated PERK-eIF2α-ATF4 signaling pathway in T-2 toxin-induced apoptosis of porcine renal epithelial cells12
Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat12
Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition12
Epidermal Growth Factor-labeled liposomes as a way to target the toxicity of silver nanoparticles into EGFR-overexpressing cancer cells in vitro12
IL-8 and MCP-1/CCL2 regulate proteolytic activity in triple negative inflammatory breast cancer a mechanism that might be modulated by Src and Erk1/212
Integrative systems toxicology to predict human biological systems affected by exposure to environmental chemicals12
MST2 silencing induces apoptosis and inhibits tumor growth for estrogen receptor alpha-positive MCF-7 breast cancer12
Crotonaldehyde-induced vascular relaxation and toxicity: Role of endothelium and transient receptor potential ankyrin-1 (TRPA1)11
Methamphetamine induces intestinal injury by altering gut microbiota and promoting inflammation in mice11
Developmental arsenic exposure induces dysbiosis of gut microbiota and disruption of plasma metabolites in mice11
Female-specific activation of pregnane X receptor mediates sex difference in fetal hepatotoxicity by prenatal monocrotaline exposure11
In silico, in vitro and in vivo evaluation of natural Bignoniaceous naphthoquinones in comparison with atovaquone targeting the selection of potential antimalarial candidates11
Arsenic metabolism differs between child and adult patients during acute arsenic poisoning11
Biological effects of inhaled hydraulic fracturing sand dust. VI. Cardiovascular effects11
Hydrogen sulfide attenuates induction and prevents progress of the 6-hydroxydopamine-induced Parkinsonism in rat through activation of ATP-sensitive potassium channels and suppression of ER stress11
OroxylinA reverses lipopolysaccharide-induced adhesion molecule expression and endothelial barrier disruption in the rat aorta11
Effects of dapagliflozin and statins attenuate renal injury and liver steatosis in high-fat/high-fructose diet-induced insulin resistant rats11
Arsenic induced epigenetic changes and relevance to treatment of acute promyelocytic leukemia and beyond11
Maltotriose-modified poly(propylene imine) Glycodendrimers as a potential novel platform in the treatment of chronic lymphocytic Leukemia. A proof-of-concept pilot study in the animal model of CLL11
Vitamin D supplementation rescues simvastatin induced myopathy in mice via improving mitochondrial cristae shape11
Metformin leads to accumulation of reactive oxygen species by inhibiting the NFE2L1 expression in human hepatocellular carcinoma cells11
Titanium dioxide nanoparticles induced reactive oxygen species (ROS) related changes of metabolomics signatures in human normal bronchial epithelial (BEAS-2B) cells11
Metabolic profile of methylazoxymethanol model of schizophrenia in rats and effects of three antipsychotics in long-acting formulation11
Metformin relieves H/R-induced cardiomyocyte injury through miR-19a/ACSL axis - possible therapeutic target for myocardial I/R injury11
Triclosan disrupts immune cell function by depressing Ca2+ influx following acidification of the cytoplasm11
Role of ferroptosis in promoting cardiotoxicity induced by Imatinib Mesylate via down-regulating Nrf2 pathways in vitro and in vivo11
Liver-specific Nrf2 deficiency accelerates ethanol-induced lethality and hepatic injury in vivo11
Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-κB activation11
Resveratrol modulates the blood plasma levels of Cu and Zn, the antioxidant status and the vascular response of thoracic arteries in copper deficient Wistar rats11
Biological effects of inhaled hydraulic fracturing sand dust. IV. Pulmonary effects11
Arsenic trioxide disturbs the LIS1/NDEL1/dynein microtubule dynamic complex by disrupting the CLIP170 zinc finger in head and neck cancer11
Species-specific differences in the inhibition of 11β-hydroxysteroid dehydrogenase 2 by itraconazole and posaconazole11
Investigating DNA adduct formation by flavor chemicals and tobacco byproducts in electronic nicotine delivery system (ENDS) using in silico approaches10
Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio10
Ovariectomy provokes inflammatory and cardiovascular effects of endotoxemia in rats: Dissimilar benefits of hormonal supplements10
In utero exposure to dipentyl phthalate disrupts fetal and adult Leydig cell development10
Comparative analysis of lung and blood transcriptomes in mice exposed to multi-walled carbon nanotubes10
MiR-3663-3p participates in the anti-hepatocellular carcinoma proliferation activity of baicalein by targeting SH3GL1 and negatively regulating EGFR/ERK/NF-κB signaling10
Picroside II alleviates liver injury induced by alpha-naphthylisothiocyanate through AMPK-FXR pathway10
Long-isoform NRF1 protects against arsenic cytotoxicity in mouse bone marrow-derived mesenchymal stem cells by suppressing mitochondrial ROS and facilitating arsenic efflux10
Empagliflozin dilates the rabbit aorta by activating PKG and voltage-dependent K+ channels10
LncRNA Mical2/miR-203a-3p sponge participates in epithelial-mesenchymal transition by targeting p66Shc in liver fibrosis10
Effects of classic antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish10
Long non-coding RNA CYTOR modulates cancer progression through miR-136-5p/MAT2B axis in renal cell carcinoma10
Identification of four methylation-driven genes as candidate biomarkers for monitoring single-walled carbon nanotube-induced malignant transformation of the lung10
Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma by blocking Wnt/β-catenin/STAT3 axis10
Transgenerational effects of developmental exposure to chlorpyrifos-oxon in zebrafish (DANIO RERIO)10
Forsythoside A inhibits adhesion and migration of monocytes to type II alveolar epithelial cells in lipopolysaccharide-induced acute lung injury through upregulating miR-12410
Elevated whole blood arsenic level is associated with type 2 diabetes in coal-burning areas in Guizhou10
Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation10
Elucidation of OATP1B1 and 1B3 transporter function using transgenic rodent models and commonly known single nucleotide polymorphisms10
Time-to-treatment window and cross-sex potential of β2-adrenergic receptor-induced mitochondrial biogenesis-mediated recovery after spinal cord injury10
Mechanism-based integrated assay systems for the prediction of drug-induced liver injury10
Developmental arsenic exposure is associated with sex differences in the epigenetic regulation of stress genes in the adult mouse frontal cortex10
Mitoglitazone ameliorates renal ischemia/reperfusion injury by inhibiting ferroptosis via targeting mitoNEET10
Pyridoxal isonicotinoyl hydrazone inhibition of FXR is involved in the pathogenesis of isoniazid-induced liver injury10
The SMAC mimetic LCL161 is a direct ABCB1/MDR1-ATPase activity modulator and BIRC5/Survivin expression down-regulator in cancer cells10
Gestational arsenic exposure and paternal intergenerational epigenetic inheritance10
Synthetic cannabinoids enhanced ethanol-induced motor impairments through reduction of central glutamate neurotransmission10
Arsenic exposure in drinking water reduces Lgr5 and secretory cell marker gene expression in mouse intestines10
Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells10
Di-(2-ethylhexyl) phthalate inhibits expression and internalization of transthyretin in human placental trophoblastic cells10
0.025362014770508