Toxicology and Applied Pharmacology

Article	Citations
Engineering human cerebral organoids to explore mechanisms of arsenic-induced developmental neurotoxicity	79
Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis	76
Dabrafenib inhibits ABCG2 and cytochrome P450 isoenzymes; potential implications for combination anticancer therapy	66
Ex vivo exposures to arsenite and its methylated trivalent metabolites alter gene transcription in mouse sperm cells	53
Development of quercetin-loaded PVCL–PVA–PEG micelles and application in inhibiting tumor angiogenesis through the PI3K/Akt/VEGF pathway	46
Safety and toxicology assessment of sodium nitrite administered by intramuscular injection	44
The ponatinib/gossypol novel combination provides enhanced anticancer activity against murine solid Ehrlich carcinoma via triggering apoptosis and inhibiting proliferation/angiogenesis	38
Delineation of the molecular mechanisms underlying Colistin-mediated toxicity using metabolomic and transcriptomic analyses	37
Liposomal methemoglobin as a potent antidote for hydrogen sulfide poisoning	37
Expression of arylamine N-acetyltransferase 2 activity in immortalized human bronchial epithelial cells	37
Berberine alleviated contrast-induced acute kidney injury by mitophagy-mediated NLRP3 inflammasome inactivation in a mice model	34
Editorial Board	33
Ethoxy-erianin phosphate and afatinib synergistically inhibit liver tumor growth and angiogenesis via regulating VEGF and EGFR signaling pathways	31
Establishment of baseline profiles of 50 bile acids in preclinical toxicity species: A comprehensive assessment of translational differences and study design considerations for biomarker development	31
An insight about the mechanism of action (MoA) of R-bicalutamide on the androgen receptor homodimer using molecular dynamic	30
Editorial Board	30
Arsenite inhibits M2a polarization of macrophages through downregulation of peroxisome proliferator-activated receptor gamma	29
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Loss of the aryl hydrocarbon receptor increases tumorigenesis in p53-deficient mice	28
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Chloroorganic (DDT) and organophosphate (malathion) insecticides impair the motor function of the bovine cervix	26
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Pegbelfermin, a PEGylated FGF21 analogue, has pharmacology without bone toxicity after 1-year dosing in skeletally-mature monkeys	26
Wood smoke particle exposure in mice reduces the severity of influenza infection	26
Neonatal metformin short exposure inhibits male reproductive dysfunction caused by a high-fat diet in adult rats	25
Functional, proteomic and phenotypic in vitro studies evidence podocyte injury after chronic exposure to heparin	25
The endocrine disruptor DE-79 alters oxytocinergic transmission and sexual behavior expression in male rats	25
Editorial Board	24
Exosome-derived miR-5p-72106_14 in vascular endothelial cells regulates fate determination of BMSCs	24
Differential effects of arsenic species on Nrf2 and Bach1 nuclear localization in cultured hepatocytes	24
Metformin relieves H/R-induced cardiomyocyte injury through miR-19a/ACSL axis - possible therapeutic target for myocardial I/R injury	24
Toxicant exposure during pregnancy increases protective proteins in the dam and a sexually dimorphic response in the fetus	24
Role of MST2/YAP1 signaling pathway in retinal cells apoptosis and diabetic retinopathy	23
Elucidating the relationship between metabolites and breast cancer: A Mendelian randomization study	23
Nimodipine inhibits intestinal and aortic smooth muscle contraction by regulating Ca2+-activated Cl− channels	23
Editorial Board	23
Can exposure to lisdexamfetamine dimesylate from juvenile period to peripubertal compromise male reproductive parameters in adult rats?	23
The effect of shikonin on the metabolism of lapatinib in vitro, and in vivo	23
Downregulation of mesenteric afferent sensitivity following long-term systemic treatment of vincristine in mice	22
Co-administration of CSL112 (apolipoprotein A-I [human]) with atorvastatin and alirocumab is not associated with increased hepatotoxic or toxicokinetic effects in rats	22
Editorial Board	22
Network pharmacology-based evaluation of natural compounds with paclitaxel for the treatment of metastatic breast cancer	21
Exposure to the bromodomain inhibitor N-methyl pyrrolidone blocks spermatogenesis in a hormonal and non-hormonal fashion	21
Role of macrophage bioenergetics in N-acetylcysteine-mediated mitigation of lung injury and oxidative stress induced by nitrogen mustard	21
The ABCB1 and ABCG2 efflux transporters limit brain disposition of the SYK inhibitors entospletinib and lanraplenib	20
Aucubin provides protection against cerebral ischaemia-reperfusion injury by suppressing neuronal apoptosis, oxidative stress, and inflammation through the modulation of the AKT-GSK-3β-Nrf2 signal cas	20
Editorial Board	20
Cardiac toxicity from bisphenol A: Are electrophysiology and calcium handling perturbations dose-dependent?	20
The pharmacologic and toxicologic characterization of the potent and selective KRAS G12D inhibitors ERAS-4693 and ERAS-5024	20
Anti-NOTCH1 therapy with OMP-52 M51 inhibits salivary adenoid cystic carcinoma by depressing epithelial-mesenchymal transition (EMT) process and inducing ferroptosis	20
Subclinical markers of cardiovascular toxicity of benzene inhalation in mice	20
Tanshinone IIA modulates cancer cell morphology and movement via Rho GTPases-mediated actin cytoskeleton remodeling	20
Effect of substituents at the C3´, C3´N, C10 and C2-meta-benzoate positions of taxane derivatives on their activity against resistant cancer cells	19
Integrated bioinformatic analysis to understand the association between phthalate exposure and breast cancer progression	19
Examination of the exposome in an animal model: The impact of high fat diet and rat strain on local and systemic immune markers following occupational welding fume exposure	19
Modulation of insulin signaling pathway genes by ozone inhalation and the role of glucocorticoids: A multi-tissue analysis	19
Weight of evidence evaluation of the metabolism disrupting effects of triphenyl phosphate using an expert knowledge elicitation approach	19
Novel insights into the N6-methyladenosine RNA modification and phytochemical intervention in lipid metabolism	19
Serum levels of IL-6/IL-10/GLDH may be early recognition markers of anti-tuberculosis drugs (ATB) -induced liver injury	19
An in vitro-in silico workflow for predicting renal clearance of PFAS	18
A novel genetically modified mouse seizure model for evaluating anticonvulsive and neuroprotective efficacy of an A1 adenosine receptor agonist following soman intoxication	18
Effect of post-gastrulation exposure to acrylamide on chick embryonic development	18
Editorial Board	18
Genomic methylation variations predict the susceptibility of six chemotherapy related adverse effects and cancer development for Chinese colorectal cancer patients	18
Transcriptomic re-analyses of human hepatocyte spheroids treated with PFAS reveals chain length and dose-dependent modes of action	18
Seizure suppression and neuroprotection in soman-exposed rats following delayed intramuscular treatment of adenosine A1 receptor agonist as an adjunct to standard medical treatment	18
KLF15 negatively regulates cardiac fibrosis by which SDF-1β attenuates cardiac fibrosis in type 2 diabetic mice	17
Role of microbial microbes in arsenic bioaccumulation and biotransformation in mice	17
Integrative description of changes occurring on zebrafish embryos exposed to water-soluble crude oil components and its mixture with a chemical surfactant	17
SNAI1-expressing fibroblasts and derived-extracellular matrix as mediators of drug resistance in colorectal cancer patients	17
Role of respiratory uncoupling in drug-induced mitochondrial permeability transition	17
Advanced oxidation protein products upregulate ABCB1 expression and activity via HDAC2-Foxo3α-mediated signaling in vitro and in vivo	17

Low-dose spironolactone combats dyslipidemia and hepatic inflammation by modulating PCSK9 in rat model of polycystic ovarian syndrome	17
Inflammation resolution in environmental pulmonary health and morbidity	17
Crocin induces ROS-mediated papillary thyroid cancer cell apoptosis by modulating the miR-34a-5p/PTPN4 axis in vitro	17
The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade	16
Duloxetine protected indomethacin-induced gastric mucosal injury by increasing serotonin-dependent RANTES expression and activating PI3K-AKT-VEGF pathway	16
Editorial Board	16
Immunosuppression, oxidative stress, and apoptosis in pig kidney caused by ammonia: Application of transcriptome analysis in risk assessment of ammonia exposure	16
The 11th Conference on metal toxicity and carcinogenesis	16
Differential inhibition of sildenafil and macitentan on saxagliptin metabolism	16
Decreased vascular contraction and changes in oxidative state in middle–aged Wistar rats after exposure to increased levels of dietary zinc	16
Association of lipid-modifying therapy with risk of obstructive sleep apnea: A drug-target mendelian randomization study	16
Synergistic anticancer effects of ginsenoside CK and gefitinib against gefitinib-resistant NSCLC by regulating the balance of angiogenic factors through HIF-1α/VEGF	16
ZC3H4 promotes pulmonary fibrosis via an ER stress-related positive feedback loop	16
Epicatechin exerts dual action to shield sickling and hydroxyurea-induced myelosuppression: Implication in sickle cell anemia management	16
Raddeanin A synergistically enhances the anti-tumor effect of MAP30 in multiple ways, more than promoting endosomal escape	15
ALKBH5 regulates paclitaxel resistance in NSCLC via inhibiting CEMIP-mediated EMT	15
Infection and disruption of placental multidrug resistance (MDR) transporters: Implications for fetal drug exposure	15
Melatonin prevents pulmonary fibrosis caused by PM2.5 exposure by targeting epithelial-mesenchymal transition	15
Post-transplantation cyclophosphamide and cyclosporine A versus methotrexate and cyclosporine A for graft-versus-host disease prophylaxis after allogeneic peripheral stem cell transplantation in adult	15
Association of urinary arsenic, polycyclic aromatic hydrocarbons, and metals with cancers among the female population in the US	15
Identification of four methylation-driven genes as candidate biomarkers for monitoring single-walled carbon nanotube-induced malignant transformation of the lung	15
TGF-β1-induced EMT activation via both Smad-dependent and MAPK signaling pathways in Cu-induced pulmonary fibrosis	15
Ganoderic acid T, a Ganoderma triterpenoid, modulates the tumor microenvironment and enhances the chemotherapy and immunotherapy efficacy through downregulating galectin-1 levels	15
Muscarinic and nicotinic receptors stimulation by vagus nerve stimulation ameliorates trastuzumab-induced cardiotoxicity via reducing programmed cell death in rats	15
The efficacy of γ-aminobutyric acid type A receptor (GABA AR) subtype-selective positive allosteric modulators in blocking tetramethylenedisulfotetramine (TETS)-induced seizure-like behavior in larval	15
Levamisole, a cocaine cutting agent, induces acute and subchronic systemic alterations in Wistar rats	15
Exposure to topiramate and acetazolamide causes endocrine disrupting effects in female rats during estrus	15
Integrated network toxicology, transcriptomics and gut microbiomics reveals hepatotoxicity mechanism induced by benzo[a]pyrene exposure in mice	15
Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy	14
Identification of novel and potential PPARγ stimulators as repurposed drugs for MCAO associated brain degeneration	14
Re-positioning of low dose paclitaxel against depressive-like behavior and neuroinflammation induced by lipopolysaccharide in rats: Crosstalk between NLRP3/caspase-1/IL-1β and Sphk1/S1P/ NF-κB signali	14
d-Tetramethrin causes zebrafish hepatotoxicity by inducing oxidative stress and inhibiting cell proliferation	14
Mitoglitazone ameliorates renal ischemia/reperfusion injury by inhibiting ferroptosis via targeting mitoNEET	14
Exploring the potential neurotoxicity of vaping vitamin E or vitamin E acetate	14
Arsenic as an immunotoxicant	14
TRAIL produced by SAM-1-activated CD4+ and CD8+ subgroup T cells induces apoptosis in human tumor cells through upregulation of death receptors	14
Editorial Board	14
Resveratrol alleviates inflammatory bowel disease by inhibiting JAK2/STAT3 pathway activity via the reduction of O-GlcNAcylation of STAT3 in intestinal epithelial cells	14
Hainanolide inhibits the progression of colon cancer via inducing the cell cycle arrest, cell apoptosis and activation of the MAPK signaling pathway	14
Estimated sensitivity profiles of lung cancer specific uncommon BRAF mutants towards experimental and clinically approved kinase inhibitors	14
Myricetin inhibits 4 T1 breast tumor growth in mice via induction of Nrf-2/GPX4 pathway-mediated Ferroptosis	14
Integrative analysis of metabolomics and proteomics reveals mechanism of berberrubine-induced nephrotoxicity	13
A systematic review of clinical and laboratory findings of lead poisoning: lessons from case reports	13
Indoprofen exerts a potent therapeutic effect against sepsis by alleviating high mobility group box 1-mediated inflammatory responses	13
Hydrogen sulfide attenuates induction and prevents progress of the 6-hydroxydopamine-induced Parkinsonism in rat through activation of ATP-sensitive potassium channels and suppression of ER stress	13
Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices	13
Arsenic trioxide inhibits the functions of lung fibroblasts derived from patients with idiopathic pulmonary fibrosis	13
Pharmacology and molecular modeling studies of sulfoxaflor, flupyradifurone and neonicotinoids on the human neuronal α7 nicotinic acetylcholine receptor	12
Bisphenol A analogues induce a feed-forward estrogenic response in zebrafish	12
Long non-coding RNA CYTOR modulates cancer progression through miR-136-5p/MAT2B axis in renal cell carcinoma	12
Dendrobine protects HACAT cells from H2O2-induced oxidative stress and apoptosis damage via Nrf2/Keap1/ARE signaling pathway	12
Arsenic-induced lung inflammation and fibrosis in a rat model: Contribution of the HMGB1/RAGE, PI3K/AKT, and TGF-β1/SMAD pathways	12
Strengths and limitations of the worm development and activity test (wDAT) as a chemical screening tool for developmental hazards	12
Editorial Board	12
Urinary polycyclic aromatic hydrocarbon, arsenic, and metal exposure and correlation with emphysema in smokers	12
Hepatotoxicity or hepatoprotection of emodin? Two sides of the same coin by 1H-NMR metabolomics profiling	12
Environmental uranium exposures and cytokine profiles among mother-newborn baby pairs from the Navajo Βirth Cohort Study	12
The role of microRNAs in regulating cadmium-induced apoptosis by targeting Bcl-2 in IEC-6 cells	12
Nimbolide attenuated the inflammation in the liver of autoimmune hepatitis's mice through regulation of HDAC3	12
Lonicerin protects pancreatic acinar cells from caerulein-induced apoptosis, inflammation, and ferroptosis by activating the SIRT1/GPX4 signaling pathway	12
Neuroprotective effects of ibudilast against tacrolimus induced neurotoxicity	12
Down-regulation of lncRNA MEG3 promotes chronic low dose cadmium exposure-induced cell transformation and cancer stem cell-like property	12
Molnupiravir; molecular and functional descriptors of mitochondrial safety	12
Toxicology profile of a novel GLP-1 receptor biased agonist-SAL0112 in nonhuman primates	12
Chloroquine may induce endothelial injury through lysosomal dysfunction and oxidative stress	12
Azoospermia and multi-organ damage in juvenile rats exposed to α-Terpineol from weaning to sexual maturity	12
1,2,4-trihydroxybenzene induces non-apoptotic cell death via the structural damage of intracellular organelles	12
Neurotoxicity study of cenobamate-induced zebrafish early developmental stages	11
Comparison of the drug-drug interactions potential of ibrutinib and acalabrutinib via inhibition of UDP-glucuronosyltransferase	11
Epigallocatechin gallate ameliorates retinal pigment epithelial cell damage via the CYFIP2 /AKT pathway	11
Enhancing toxicity prediction for natural products in herbal medicine and dietary supplements: Integrating (Q)STR models and in vitro assays	11
Lupeol, an androgen receptor inhibitor, enhances the chemosensitivity of prostate cancer stem cells to antiandrogen enzalutamide-based therapy	11
Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX	11
Up-regulation of RNA m6A methyltransferase like-3 expression contributes to arsenic and benzo[a]pyrene co-exposure-induced cancer stem cell-like property and tumorigenesis	11
Neuregulin 1 improved gastric motility and reduced gastric inflammation by activating the α7nAChR through the cholinergic anti-inflammatory pathway in diabetic rats	11
Melatonin alleviates doxorubicin-induced mitochondrial oxidative damage and ferroptosis in cardiomyocytes by regulating YAP expression	11
Editorial Board	11
Effects of electronic cigarette E-liquid and device wattage on vascular function	11
Embryonic exposure to acetamiprid insecticide induces CD68-positive microglia and Purkinje cell arrangement abnormalities in the cerebellum of neonatal rats	11
A computational model of the crosstalk between hepatocyte fatty acid metabolism and oxidative stress highlights the key enzymes, metabolites, and detoxification pathways in the context of MASLD	11

Anti-inflammatory effects of cannabidiol in early stages of neuroinflammation induced by high-fat diet in cerebral cortex of rats	11
The HDAC inhibitor HFY-4A improves TUSC2 transcription to induce immunogenic cell death in breast cancer	11
Corrigendum to “Curcumin enhances recovery of pancreatic islets from cellular stress induced inflammation and apoptosis in diabetic rats” [Toxicology and Applied Pharmacology, 282 (2015) 297–310]	10
Apigenin alleviates cancer drug Sorafenib induced multiple toxic effects in Swiss albino mice via anti-oxidative stress	10
Application of Cell Painting for chemical hazard evaluation in support of screening-level chemical assessments	10
The role of NUPR1 in response to stress and cancer development	10
Hepatic and ovarian effects of perfluorooctanoic acid exposure differ in lean and obese adult female mice	10
Amentoflavone prevents ox-LDL-induced lipid accumulation by suppressing the PPARγ/CD36 signal pathway	10
Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPARα mice fed an American diet	10
Corrigendum to “Diosgenin alleviates hypercholesterolemia via SRB1/CES-1/CYP7A1/FXR pathway in high-fat diet-fed rats” Toxicology and Applied Pharmacology, volume 412C (2021)	10
Toxicokinetic evaluation of the common indoor air pollutant, α-pinene, and its potential reactive metabolite, α-pinene oxide, following inhalation exposure in rodents	10
Dihydromyricetin attenuates cisplatin-induced acute kidney injury by reducing oxidative stress, inflammation and ferroptosis	10
Kynurenic acid ameliorates lipopolysaccharide-induced endometritis by regulating the GRP35/NF-κB signaling pathway	10
The therapeutic effect of hesperetin on doxorubicin-induced testicular toxicity: Potential roles of the mechanistic target of rapamycin kinase (mTOR) and dynamin-related protein 1 (DRP1)	10
Sodium dichloroisocyanurate toxicity in rats during a 90-day inhalation toxicity study	10
Platinum-based chemotherapy induces demyelination of Schwann cells in oral squamous cell carcinoma treatment	10
Integrated analysis of microRNA expression profiles and function network in mice testes after low dose lead exposure from early puberty	10
Corrigendum to “Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells” [Toxicology and Applied Pharmacology 319 (20	10
Heavy metals, oxidative stress, and the role of AhR signaling	10
Species-specific differences in the inhibition of 11β-hydroxysteroid dehydrogenase 2 by itraconazole and posaconazole	10
Towards translating in vitro measures of thyroid hormone system disruption to in vivo responses in the pregnant rat via a biologically based dose response (BBDR) model	10
Involvement of endoplasmic reticulum stress-activated PERK-eIF2α-ATF4 signaling pathway in T-2 toxin-induced apoptosis of porcine renal epithelial cells	10
Crosstalk between the aryl hydrocarbon receptor (AhR) and the peroxisome proliferator-activated receptor gamma (PPARγ) as a key factor in the metabolism of silver nanoparticles in neuroblastoma (SH-SY	10
The path via pathway-based approaches towards safety assessment: A concise review	10
Curcumin ameliorates hypertension via gut-brain communication in spontaneously hypertensive rat	10
Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio	10
Corrigendum to “The role of PTEN in regulation of hepatic macrophages activation and function in progression and reversal of liver fibrosis” [Toxicology and Applied Pharmacology 317 (2017) 51–62]	10
Molecular and clinical insights of matrix metalloproteinases into cancer spread and potential therapeutic interventions	9
Involvement of TCF7L2 in generation of morphine-induced antinociceptive tolerance and hyperalgesia by modulating TLR4/ NF-κB/NLRP3 in microglia	9
Prognostic biomarker prediction for glioma induced by heavy metals and their mixtures: An in-silico study	9
Titanium dioxide nanoparticles induced reactive oxygen species (ROS) related changes of metabolomics signatures in human normal bronchial epithelial (BEAS-2B) cells	9
Natural products in the reprogramming of cancer epigenetics	9
Zinc finger protein 367 exerts a cancer-promoting role in small cell lung cancer by influencing the CIT/LATS2/YAP signaling cascade	9
Editorial Board	9
Corrigendum to “Valproate induced hepatic steatosis by enhanced fatty acid uptake and triglyceride synthesis” [Toxicology and Applied Pharmacology 324 (2017) 12-25]	9
Inhibition of CDGSH iron‑sulfur domain 2 exhibits tumor-suppressing effects on diffuse large B-cell lymphoma (DLBCL) by inducing ferroptosis through the regulation of the NRF2/SLC7A11/GPX4 pathway	9
Epigenetic modifications control CYP1A1 Inducibility in human and rat keratinocytes	9
Chromium distribution in an oropharyngeal aspiration model for hexavalent chromium in rats	9
Editorial Board	9
SLC11A1 promotes kidney renal clear cell carcinoma (KIRC) progression by remodeling the tumor microenvironment	9
Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data	9
Prepubertal to adulthood exposure to low doses of glyphosate-based herbicide increases the expression of the Havcr1 (Kim1) biomarker and causes mild kidney alterations	9
Corrigendum to “Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6) are associated with long term tramadol treatment-induced oxidative damage and hepatotoxicity” [Toxicology and Applied Pharmacology	9
Corrigendum to “PKC-δ-dependent mitochondrial ROS attenuation is involved as 9-OAHSA combats lipoapotosis in rat hepatocytes induced by palmitic acid and in Syrian hamsters induced by high-fat high-ch	9
Roflupram attenuates α-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant α-synuclein	9
Stage-, dose-, and course-dependent inhibition of prenatal amoxicillin exposure on fetal articular cartilage development in fetal mice	9
Targeting CD166+ lung cancer stem cells: Molecular study using murine dendritic cell vaccine	9
Ozone impairs endogenous compensatory responses in allergic asthma	9
Angiotensin IV ameliorates doxorubicin-induced cardiotoxicity by increasing glutathione peroxidase 4 and alleviating ferroptosis	9
Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress	9
Hydroxysafflor yellow A protects against colitis in mice by suppressing pyroptosis via inhibiting HK1/NLRP3/GSDMD and modulating gut microbiota	9
Thymoquinone inhibits Neuroinflammatory mediators and vasoconstriction injury via NF-κB dependent NeuN/GFAP/Ki-67 in hypertensive Dams and F1 male pups on exposure to a mixture of Bisphenol-A analogue	9
New insights into the mechanisms underlying 5-hydroxymethylfurfural-induced suppression of testosterone biosynthesis in vivo and in vitro	9
Pre-pubertal obesity compromises ovarian oxidative stress, DNA repair and chemical biotransformation	9
Deficiency of NLR family member NLRC5 alleviates alcohol induced hepatic injury and steatosis by enhancing autophagy of hepatocytes	8
An oat fiber intervention for reducing PFAS body burden: A pilot study in male C57Bl/6 J mice	8
Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity and the underlying mechanism	8
Preclinical safety and efficacy of the recombinant CR1 drug product CSL040 in rats and cynomolgus monkeys	8
Potential for TCDD to induce regulatory functions in B cells as part of the mechanism for T cell suppression in EAE	8
Corrigendum to “Nrf2 deficiency aggravates the increase in osteoclastogenesis and bone loss induced by inorganic arsenic” [Toxicology and applied pharmacology 367 (2019) 62–70]	8
SERCA2 protects against cisplatin-induced damage of auditory cells: Possible relation with alleviation of ER stress	8
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways	8
Astrocytic Kir4.1 regulates NMDAR/calpain signaling axis in lipopolysaccharide-induced depression-like behaviors in mice	8
PARP inhibitor BMN-673 induced apoptosis by trapping PARP-1 and inhibiting base excision repair via modulation of pol-β in chromatin of breast cancer cells	8
Simvastatin attenuates acute lung injury by activation of A2B adenosine receptor	8
The interaction of disulfiram and H2S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth	8
The effects of UGT1A4 and ABCB1 polymorphisms on clozapine and N- desmethyl clozapine plasma levels in Turkish schizophrenia patients	8
Cadmium-induced iron dysregulation contributes to functional impairment in brain endothelial cells via the ferroptosis pathway	8
Safety assessment on CBD-rich hemp extract in sub-chronic cross-sex study with rats	8
Cadmium alters the cellular metabolome of human ovarian granulosa cells	8
Metabolism of inorganic arsenic in mice carrying the human AS3MT gene and fed folate deficient or folate supplemented diet	8
The myosin II inhibitor, blebbistatin, ameliorates pulmonary endothelial barrier dysfunction in acute lung injury induced by LPS via NMMHC IIA/Wnt5a/β-catenin pathway	8
Immunomodulation of susceptibility to pneumococcal pneumonia infection in mouse lungs exposed to carbon nanoparticles via dysregulation of innate and adaptive immune responses	8
Selective modulation of placental and fetal MDR transporters by chronic in utero exposure to NRTIs in Sprague-Dawley rats: Importance for fetoprotection	8
Effects of 1, 2-bis (2,4, 6-tribromophenoxy) ethane and bis (2-ethylhexyl) tetrabromophthalate on serum metabolic and lipid profiles in male rats	8
T-2 toxin triggers immunotoxic effects in goats by inducing ferroptosis and neutrophil extracellular traps	8
Evaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish	8
Evaluation of human relevance of Nicofluprole-induced rat thyroid disruption	8
Effects of fungicides on the ultrastructure of the hypopharyngeal glands and the strength of the hives of Apis mellifera Linnaeus, 1758 (Hymenoptera: Apidae)	8
CREB1 protects against the renal injury in a rat model of kidney stone disease and calcium oxalate monohydrate crystals-induced injury in NRK-52E cells	8
Effects of used and under-used doses of Transfluthrin-based insecticide on Caenorhabditis elegans metabolism	8
The interaction between Hsp90-mediated unfolded protein response and autophagy contributes to As3+/ Se4+ combination-induced apoptosis of acute promyelocytic leukemia cells	8
Cardiac inotropy and cardiac calcium sensitization of PanLN800(-Forte), a cationic heptamethine indocyanine fluorescent contrast agent for intraoperative pan lymph node imaging	8
Cadmium biphasically impacts the adaptive immune system via regulating mitochondrial activation of hematopoietic stem cells in mice	8
Thiostrepton suppresses colorectal cancer progression through reactive oxygen species related endoplasmic reticulum stress	8
WITHDRAWN: Construction and evaluation of risk prediction model for kidney injury in patients treated with PD-1 inhibitors	8
PBK modelling of topical application and characterisation of the uncertainty of Cmax estimate: A case study approach	8
AKT inhibitor AZD5363 suppresses stemness and promotes anti-cancer activity of 3,3′-diindolylmethane in human breast cancer cells	8
Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil	8
Exposure to environmentally relevant concentrations of di-(2-ethylhexyl) phthalate (DEHP) induced reproductive toxicity in female koi carp (Cyprinus carpio)	8
Corrigendum to “Casticin inhibits stemness of hepatocellular carcinoma cells via disrupting the reciprocal negative regulation between DNMT1 and miR-148a-3p” [Toxicology and Applied Pharmacology 396 (	8
The surfactant Dioctyl Sodium Sulfosuccinate (DOSS) exposure causes adverse effects in embryos and adults of zebrafish (Danio rerio)	8
Beneficial effects of metformin supplementation in hypothalamic paraventricular nucleus and arcuate nucleus of type 2 diabetic rats	8
Zebrafish early life stages as alternative model to study ‘designer drugs’: Concordance with mammals in response to opioids	8
Baicalin nanoemulsion mitigates cisplatin-induced hepatotoxicity by alleviating oxidative stress, inflammation, and restoring cellular integrity	8