Toxicology and Applied Pharmacology

Article	Citations
Berberine alleviated contrast-induced acute kidney injury by mitophagy-mediated NLRP3 inflammasome inactivation in a mice model	98
Editorial Board	73
Raddeanin A synergistically enhances the anti-tumor effect of MAP30 in multiple ways, more than promoting endosomal escape	64
Role of microbial microbes in arsenic bioaccumulation and biotransformation in mice	55
Establishment of baseline profiles of 50 bile acids in preclinical toxicity species: A comprehensive assessment of translational differences and study design considerations for biomarker development	48
Lonicerin protects pancreatic acinar cells from caerulein-induced apoptosis, inflammation, and ferroptosis by activating the SIRT1/GPX4 signaling pathway	46
Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX	44
Indoprofen exerts a potent therapeutic effect against sepsis by alleviating high mobility group box 1-mediated inflammatory responses	42
Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPARα mice fed an American diet	42
Integrated analysis of microRNA expression profiles and function network in mice testes after low dose lead exposure from early puberty	41
Epigenetic modifications control CYP1A1 Inducibility in human and rat keratinocytes	40
Cardiac toxicity from bisphenol A: Are electrophysiology and calcium handling perturbations dose-dependent?	38
The efficacy of γ-aminobutyric acid type A receptor (GABA AR) subtype-selective positive allosteric modulators in blocking tetramethylenedisulfotetramine (TETS)-induced seizure-like behavior in larval	38
Nrf2 deficiency aggravates hepatic cadmium accumulation, inflammatory response and subsequent injury induced by chronic cadmium exposure in mice	37
Neuregulin 1 improved gastric motility and reduced gastric inflammation by activating the α7nAChR through the cholinergic anti-inflammatory pathway in diabetic rats	36
The role of microRNAs in regulating cadmium-induced apoptosis by targeting Bcl-2 in IEC-6 cells	36
Mitochondrial iron deficiency mediated inhibition of ecdysone synthesis underlies lead (Pb) induced developmental toxicity in Drosophila melanogaster	36
Integrative analysis of metabolomics and proteomics reveals mechanism of berberrubine-induced nephrotoxicity	35
Exploring the mechanism of baicalein on breast cancer based on network pharmacology, molecular docking and in vivo experiments	35
Serum levels of IL-6/IL-10/GLDH may be early recognition markers of anti-tuberculosis drugs (ATB) -induced liver injury	35
Apigenin alleviates cancer drug Sorafenib induced multiple toxic effects in Swiss albino mice via anti-oxidative stress	34
Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio	33
Hydrogen sulfide attenuates induction and prevents progress of the 6-hydroxydopamine-induced Parkinsonism in rat through activation of ATP-sensitive potassium channels and suppression of ER stress	32
Co-administration of CSL112 (apolipoprotein A-I [human]) with atorvastatin and alirocumab is not associated with increased hepatotoxic or toxicokinetic effects in rats	32
Anti-NOTCH1 therapy with OMP-52 M51 inhibits salivary adenoid cystic carcinoma by depressing epithelial-mesenchymal transition (EMT) process and inducing ferroptosis	32

Infection and disruption of placental multidrug resistance (MDR) transporters: Implications for fetal drug exposure	30
Synergistic anticancer effects of ginsenoside CK and gefitinib against gefitinib-resistant NSCLC by regulating the balance of angiogenic factors through HIF-1α/VEGF	29
The therapeutic effect of hesperetin on doxorubicin-induced testicular toxicity: Potential roles of the mechanistic target of rapamycin kinase (mTOR) and dynamin-related protein 1 (DRP1)	29
Mitoglitazone ameliorates renal ischemia/reperfusion injury by inhibiting ferroptosis via targeting mitoNEET	29
Azoospermia and multi-organ damage in juvenile rats exposed to α-Terpineol from weaning to sexual maturity	28
Towards translating in vitro measures of thyroid hormone system disruption to in vivo responses in the pregnant rat via a biologically based dose response (BBDR) model	28
Arsenic-induced lung inflammation and fibrosis in a rat model: Contribution of the HMGB1/RAGE, PI3K/AKT, and TGF-β1/SMAD pathways	28
Application of Cell Painting for chemical hazard evaluation in support of screening-level chemical assessments	28
Liposomal methemoglobin as a potent antidote for hydrogen sulfide poisoning	28
Safety assessment on CBD-rich hemp extract in sub-chronic cross-sex study with rats	27
Curcumin alleviated dextran sulfate sodium-induced ulcerative colitis via inhibition of the Wnt/β-catenin signaling pathway and regulation of the differentiation of intestinal stem cells	27
Evaluation of dermal toxicity and toxicokinetics of povidone‑iodine in Göttingen minipigs	27
Subclinical markers of cardiovascular toxicity of benzene inhalation in mice	27
In utero di-(2-ethylhexyl) phthalate-induced testicular dysgenesis syndrome in male newborn rats is rescued by taxifolin through reducing oxidative stress	26
Editorial Board	26
Toxicological and biochemical mechanisms of pesticides in non-targeted biological systems	26
Gene regulation by morpholines and piperidines in the cardiac embryonic stem cell test	26
Isorhynchophylline ameliorates paraquat-induced acute kidney injury by attenuating oxidative stress and mitochondrial damage via regulating toll-interacting expression	26
Editorial Board	26
NRF2-ARE signaling is responsive to haloacetonitrile-induced oxidative stress in human keratinocytes	25
Pinoresinol diglucoside mitigates dexamethasone-induced osteoporosis and chondrodysplasia in zebrafish	25
Zebrafish early life stages as alternative model to study ‘designer drugs’: Concordance with mammals in response to opioids	24
An experimental evaluation of the efficacy of perinatal sulforaphane supplementation to decrease the incidence and severity of vinclozolin-induced hypospadias in the mouse model	24
Neuroprotective effects of saxagliptin against radiation-induced cognitive impairment: Insights on Akt/CREB/SIRT1/BDNF signaling pathway	24
A rational approach to assess off-target reactivity of a dual-signal integrator for T cell therapy	24
Subacute exposure to Roundup® changes steroidogenesis and gene expression of the glutathione-glutaredoxin system in rat ovaries: Implications for ovarian toxicity of this glyphosate-based herbicide	24
Cinacalcet as a surrogate therapy for diabetic cardiomyopathy in rats through AMPK-mediated promotion of mitochondrial and autophagic function	24
Glyphosate-based herbicide causes spermatogenesis disorder and spermatozoa damage of the Chinese mitten crab (Eriocheir sinensis) by affecting testes characteristic enzymes, antioxidant capacities and	23
Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data	23
Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus L.) exerts multidirectional pro-healing properties towards damaged zebrafish hair cells by regulating the innate immune response	23
A novel indazole derivative, compound Cyy-272, attenuates LPS-induced acute lung injury by inhibiting JNK phosphorylation	23
Effects of heated tobacco product aerosol extracts on DNA methylation and gene transcription in lung epithelial cells	23
Prenatal exposure to arsenic promotes sterile inflammation through the Polycomb repressive element EZH2 and accelerates skin tumorigenesis in mouse	23
Thiostrepton suppresses colorectal cancer progression through reactive oxygen species related endoplasmic reticulum stress	22
Toxic effects of prenatal azithromycin exposure on fetal adrenal gland in mice: The role of stage, dose and course of treatment	22
Angiotensin IV ameliorates doxorubicin-induced cardiotoxicity by increasing glutathione peroxidase 4 and alleviating ferroptosis	21
Beneficial effects of metformin supplementation in hypothalamic paraventricular nucleus and arcuate nucleus of type 2 diabetic rats	21
The interaction between Hsp90-mediated unfolded protein response and autophagy contributes to As3+/ Se4+ combination-induced apoptosis of acute promyelocytic leukemia cells	21
A regulatory relic: After 60 years of research on cancer risk, the Delaney Clause continues to keep us in the past	21
Hexavalent chromium increases the metabolism and genotoxicity of aromatic amine carcinogens 4-aminobiphenyl and β-naphthylamine in immortalized human lung epithelial cells	21
Ameliorative effect of nano-pregabalin in gastrocnemius muscle of gamma irradiated rats with an experimental model of fibromyalgia: Crosstalk of Sirt3, IL-1β and PARP1 pathways	21
Redox aspects of cytotoxicity and anti-neuroinflammatory profile of chloroquine and hydroxychloroquine in serum-starved BV-2 microglia	21
Methionine redox regulation of actin-interacting proteins primarily governs antioxidative signaling and response to the salvianolic acid B treatment in EA.hy926 cells	21
Kaempferol and ginsenoside Rg1 ameliorate acute hypobaric hypoxia induced lung injury based on network pharmacology analysis	20
Hepatic biotransformation of non-psychotropic phytocannabinoids and activity screening on cytochromes P450 and UDP-glucuronosyltransferases	20
Cardiac inotropy and cardiac calcium sensitization of PanLN800(-Forte), a cationic heptamethine indocyanine fluorescent contrast agent for intraoperative pan lymph node imaging	20
Cadmium alters the cellular metabolome of human ovarian granulosa cells	20
Editorial Board	19
β-Sitosterol protects against lithocholic acid-induced hepatotoxicity and cholestasis via farnesoid X receptor-mediated regulation of transporters and enzymes in vitro and in vivo	19
ROS responsive nanozyme loaded with STING silencing for the treatment of sepsis-induced acute lung injury	19

Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin	19
Evaluation of several farnesyloxycarbostyril derivatives as potential 15-LOX-1 inhibitors for prostate cancer treatment	19
Toxic element contaminations of prenatal vitamins	19
The myosin II inhibitor, blebbistatin, ameliorates pulmonary endothelial barrier dysfunction in acute lung injury induced by LPS via NMMHC IIA/Wnt5a/β-catenin pathway	19
The contribution of the neuroendocrine system to adaption after repeated daily ozone exposure in rats	19
Editorial Board	18
An improved in vitro model simulating the feto-maternal interface to study developmental effects of potentially toxic compounds: The example of titanium dioxide nanoparticles	18
Linking chemicals, genes and morphological perturbations to diseases	18
Evaluation of the distribution and excretion of [14C]-inclisiran following single subcutaneous administration in cynomolgus monkeys	18
Hexavalent chromium inhibits myogenic differentiation and induces myotube atrophy	18
Resveratrol attenuates atherosclerotic endothelial injury through the Pin1/Notch1 pathway	18
PI3K inhibitor “alpelisib” alleviates methotrexate induced liver injury in mice and potentiates its cytotoxic effect against MDA-MB-231 triple negative breast cancer cell line	18
Bioinformatics and network pharmacology identify promotional effects and potential mechanisms of ethanol on esophageal squamous cell carcinoma and experimental validation	18
Prenatal arsenite exposure alters maternal cardiac remodeling during late pregnancy	18
Metabolomics of V2O5 nanoparticles and V2O5 nanofibers in human airway epithelial BEAS-2B cells	18
Effects of catechin on the malignant biological behavior of gastric cancer cells through the PI3K/Akt signaling pathway	18
Ginsenoside Rg3 attenuates the stemness of breast cancer stem cells by activating the hippo signaling pathway	18
Comparative study of estrogenic activities of phytoestrogens using OECD in vitro and in vivo testing methods	18
Acacetin induces sustained ERK1/2 activation and RIP1-dependent necroptotic death in breast cancer cells	18
The downregulation of TREM2 exacerbates toxicity of development and neurobehavior induced by aluminum chloride and nano-alumina in adult zebrafish	17
Effects of exposure to the neonicotinoid pesticide clothianidin on mouse intestinal microbiota under unpredictable environmental stress	17
Ononin alleviates endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity by activating SIRT3	17
A tribute to Scott W. Burchiel, PHD	17
The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice	17
Arsenic up-regulates PD-L1 and enhances lung tumorigenesis through activation of STAT3 in alveolar epithelial type 2 cells	17
Editorial Board	17
Perfluorooctanoic acid (PFOA) promotes follicular growth and alters expression of genes that regulate the cell cycle and the Hippo pathway in cultured neonatal mouse ovaries	17
A systematic review of mechanistic studies on the relationship between pesticide exposure and cancer induction	16
Editorial Board	16
Can we do better with Mylotarg? Model-based assessment of opportunities to improve therapeutic index	16
Lactational transfer of sulforaphane-N-acetylcysteine in vivo and in human breast milk	16
Yersinia enterocolitica and Lactobacillus fermentum induces differential cellular and behavioral responses during diclofenac biotransformation in rat gut	16
Remdesivir; molecular and functional measures of mitochondrial safety	16
Pulmonary inflammation and cellular responses following exposure to benzalkonium chloride: Potential impact of disrupted pulmonary surfactant homeostasis	16
Protective effect of genistein pre-treatment on paraquat hepatotoxicity in rats	16
Hesperidin attenuates radiation-induced ovarian failure in rats: Emphasis on TLR-4/NF-ĸB signaling pathway	16
Does maternal exposure to nicotine affect the oocyte quality and reproductive capacity in adult offspring?	16
γ-Glutamylcysteine restores glucolipotoxicity-induced islet β-cell apoptosis and dysfunction via inhibiting endoplasmic reticulum stress	16
Detection of intracellular lamellar bodies as a screening marker for fibrotic lesions	16
Esketamine induces apoptosis of nasopharyngeal carcinoma cells through the PERK/CHOP pathway	15
Fucoxanthin ameliorates ulcerative colitis by maintaining the epithelial barrier via blocking JAK2/STAT3 signaling pathway	15
A coordinated ruthenium-rifampicin complex reprogramming the colon carcinoma micro-environment mediated by modulation of p53/AkT/mTOR/VEGF pathway	15
TRPC6 promotes daunorubicin-induced mitochondrial fission and cell death in rat cardiomyocytes with the involvement of ERK1/2-DRP1 activation	15
Formononetin ameliorates DSS-induced colitis by inhibiting the MAPK/PPAR-γ/NF-κB/ROS signaling pathways	15
Cysteine and glycine-rich protein 2 is crucial for maintaining the malignant phenotypes of gliomas through its action on Notch signalling cascade	14
Vitamin D3 and Salinomycin synergy in MCF-7 cells cause cell death via endoplasmic reticulum stress in monolayer and 3D cell culture	14
4-Acetylantroquinonol B induced DNA damage response signaling and apoptosis via suppressing CDK2/CDK4 expression in triple negative breast cancer cells	14
Apoptotic mechanism of development inhibition in zebrafish induced by esketamine	14
Chlorogenic acid, rutin, and quercetin from Lysimachia christinae alleviate triptolide-induced multi-organ injury in vivo by modulating immunity and AKT/mTOR signal pathway to inhibit ferroptosis and	14
Neuroprotection by delayed triple therapy following sarin nerve agent insult in the rat	14
Toxicokinetics of mono-(2-ethylhexyl) phthalate with low-dose exposure applying fluorescence tracing technique	14
Adrenergic receptor subtypes differentially influence acrolein-induced ventilatory, vascular leakage, and inflammatory responses	14
Levocabastine ameliorates cyclophosphamide-induced cardiotoxicity in Swiss albino mice: Targeting TLR4/NF-κB/NLRP3 signaling pathway	14
Defining high confidence targets of differential CpG methylation in response to in utero arsenic exposure and implications for cancer risk	14
Vascular endothelial-derived Von Willebrand factor inhibits lung cancer progression through the αvβ3/ERK1/2 axis	14
Physical analysis reveals distinct responses of human bronchial epithelial cells to guanidine and isothiazolinone biocides	14
Structure dependence and species sensitivity of in vivo hepatobiliary toxicity with lysophosphatidic acid receptor 1 (LPA1) antagonists	14
Inorganic arsenic exposure-induced premature senescence and senescence-associated secretory phenotype (SASP) in human hepatic stellate cells	14
Zinc supplementation alters tissue distribution of arsenic in Mus musculus	14
Acute ammonia stress affects the immune response, oxidative stress, ammonia transport and detoxication in the hepatopancreas of freshwater mollusk Solenaia oleivora	14
Circadian disruption and cisplatin chronotherapy for mammary carcinoma	14
Targeted Per- and Polyfluoroalkyl substances (PFAS) assessments for high throughput screening: Analytical and testing considerations to inform a PFAS stock quality evaluation framework	13
Role of ferroptosis in promoting cardiotoxicity induced by Imatinib Mesylate via down-regulating Nrf2 pathways in vitro and in vivo	13
Icariin promotes mouse Leydig cell testosterone synthesis via the Esr1/Src/Akt/Creb/Sf-1 pathway	13
Centromere protein K enhances the activation of YAP1/TAZ signal cascade to drive the progression of clear cell renal cell carcinoma	13
The effects of sodium sulfite on Helicobacter pylori by establishing a hypoxic environment	13
Cyanidin improves spatial memory and cognition in bisphenol A-induced rat model of Alzheimer's-like neuropathology by restoring canonical Wnt signaling	13
Fangchinoline alleviates the progression of osteoarthritis through the nuclear factor kappa B signaling pathway	13
Methylglyoxal produced by tumor cells through formaldehyde-enhanced Warburg effect potentiated polarization of tumor-associated macrophages	13
Exposure of environmental trace elements in prostate cancer patients: A multiple metal analysis	13
Analysis of accumulation of DNA double-strand breaks in mouse tissues by pulsed-field gel electrophoresis	13
Investigating the anticancer properties of urolithin B in triple negative breast cancer: In vivo and in vitro insights	13
Social isolation exacerbates acute ozone inhalation induced pulmonary and systemic health outcomes	13
Gallic acid ameliorates synovial inflammation and fibrosis by regulating the intestinal flora and its metabolites	13
Protective effect of rupatadine on testicular ischemia/reperfusion injury in rats: Modulation of IL-6/STAT3, Akt/ mTOR signaling pathways	13
Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma by blocking Wnt/β-catenin/STAT3 axis	13
Inhibition of tumor migration and invasion by fenofibrate via suppressing epithelial-mesenchymal transition in breast cancers	13
Effect of pharmacological modulation of the kynurenine pathway on pain-related behavior and opioid analgesia in a mouse model of neuropathic pain	13
Delivery of doxorubicin loaded P18 conjugated-poly(2-ethyl-oxazoline)-DOPE nanoliposomes for targeted therapy of breast cancer	13
Fenpropathrin provoked kidney damage via controlling the NLRP3/Caspase-1/GSDMD–mediated pyroptosis: The palliative role of curcumin-loaded chitosan nanoparticles	13

Chronic escalating-dose and acute binge cocaine treatments change the hippocampal cholinergic muscarinic system on drug presence and after withdrawal	13
Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells	13
The rapid transformation of triclosan in the liver reduces its effectiveness as inhibitor of hepatic energy metabolism	13
Ameliorative effect of Schisandrol B against Diosbulbin B-induced hepatotoxicity via inhibiting CYP3A4-mediated bioactivation	13
Cepharanthine inhibits the proliferation of glioblastoma cells by blocking the autophagy–lysosomal pathway	12
Dibutylstannanediyl (2Z,2′Z)-bis(4-(benzylamino)-4-oxobut-2-enoate inhibits prostate cancer progression by activating p38 MAPK/PPARα/SMAD4 signaling	12
The early inhibition of the COX-2 pathway in viperid phospholipase A2-induced skeletal muscle myotoxicity accelerates the tissue regeneration	12
Editorial Board	12
Advances in research strategies and approaches for toxicity testing of environmental exposures	12
Protein S-palmitoylation enhances profibrotic signaling in response to cadmium	12
Desloratadine mitigates hepatocellular carcinoma in rats: Possible contribution of TLR4/MYD88/NF-κB pathway	12
The anti-cancer drug candidate CBL0137 induced necroptosis via forming left-handed Z-DNA and its binding protein ZBP1 in liver cells	12
Novel microtubule inhibitor SQ overcomes multidrug resistance in MCF-7/ADR cells by inhibiting BCRP function and mediating apoptosis	12
Inflammation resolution in environmental pulmonary health and morbidity	12
Structural determinants of parabens in inhibiting human and rat gonadal 3β-hydroxysteroid dehydrogenase	12
Corrigendum to “Differentiation of sow and mouse ovarian granulosa cells exposed to zearalenone in vitro using RNA-seq gene expression” [Toxicology and Applied Pharmacology, 350 (2018) 78–90]	12
Functional evaluation of CYP2C19 and CYP3A4 gene polymorphism on ibuprofen metabolism	12
New insight into methamphetamine-associated heart failure revealed by transcriptomic analyses: Circadian rhythm disorder	12
Assessing the neurotoxicity of airborne nano-scale particulate matter in human iPSC-derived neurons using a transcriptomics benchmark dose model	12
Editorial Board	12
Effect of pretreatment with a synbiotic on Perfluorooctanoic acid-induced liver damage after sub-acute oral exposure in C57BL/6J mice	12
Changes in the gut microbiota of rats after exposure to the fungicide Mancozeb	12
Benzo(a)pyrene exposure in utero exacerbates Parkinson's Disease (PD)-like α-synucleinopathy in A53T human alpha-synuclein transgenic mice	12
Naproxen sodium nanoparticles are less toxic and gastroprotective agents than the conventional NSAID drug naproxen sodium in Balb/c mice	11
AhR signaling modulates Ferroptosis by regulating SLC7A11 expression	11
Salvianolic acid B improves mitochondrial dysfunction of septic cardiomyopathy via enhancing ATF5-mediated mitochondrial unfolded protein response	11
Anemoside A3 activates TLR4-dependent M1-phenotype macrophage polarization to represses breast tumor growth and angiogenesis	11
In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen recept	11
Clozapine affects the pharmacokinetics of risperidone and inhibits its metabolism and P-glycoprotein–mediated transport in vivo and in vitro: A safety attention to antipsychotic polypharmacy with cloz	11
Higher susceptibility of males to bleomycin-induced pulmonary inflammation is associated with sex-specific transcriptomic differences in myeloid cells	11
Celastrol alleviates high-fat diet-induced obesity via enhanced muscle glucose utilization and mitochondrial oxidative metabolism-mediated upregulation of pyruvate dehydrogenase complex	11
Plasma microRNA-195, −34c, and − 1246 as novel biomarkers for the diagnosis of trastuzumab-resistant HER2-positive breast cancer patients	11
Benzyl isothiocyanate attenuates activation of the NLRP3 inflammasome in Kupffer cells and improves diet-induced steatohepatitis	11
Pirfenidone ameliorates ANIT-induced cholestatic liver injury via modulation of FXR, NF-кB/TNF-α, and Wnt/GSK-3β/β-catenin signaling pathways	11
Tributyltin protects against ovariectomy-induced trabecular bone loss in C57BL/6J mice with an attenuated effect in high fat fed mice	11
Prestin and otolin-1 proteins in the hearing loss of adults chronically exposed to lead	11
Oxytetracycline induces anxiety-like behavior in adult zebrafish	11
Ursolic acid alleviates steroid-induced avascular necrosis of the femoral head in mouse by inhibiting apoptosis and rescuing osteogenic differentiation	11
Sodium cantharidate induces Apoptosis in breast cancer cells by regulating energy metabolism via the protein phosphatase 5-p53 axis	11
Quantification and cytotoxicity of degradation products (chloropropanols) in sucralose containing e-liquids with propylene glycol and glycerol as base	11
Donepezil protects against cyclophosphamide-induced premature ovarian failure in mice: A focus on proinflammatory cytokines and NLRP3/TLR-4/NF-κB interplay	11
Protective effects of microbial biosurfactants produced by Bacillus halotolerans and Candida parapsilosis on bleomycin-induced pulmonary fibrosis in mice: Impact of antioxidant, anti-inflammatory and	11
Thymic lymphoma detection in RORγ knockout mice using 5-hydroxymethylcytosine profiling of circulating cell-free DNA	11
PREX1 depletion ameliorates high-fat diet-induced non-alcoholic fatty liver disease in mice and mitigates palmitic acid-induced hepatocellular injury via suppressing the NF-κB signaling pathway	10
Modulation of insulin signaling pathway genes by ozone inhalation and the role of glucocorticoids: A multi-tissue analysis	10
Aucubin provides protection against cerebral ischaemia-reperfusion injury by suppressing neuronal apoptosis, oxidative stress, and inflammation through the modulation of the AKT-GSK-3β-Nrf2 signal cas	10
Editorial Board	10
Editorial Board	10
Delineation of the molecular mechanisms underlying Colistin-mediated toxicity using metabolomic and transcriptomic analyses	10
ALKBH5 regulates paclitaxel resistance in NSCLC via inhibiting CEMIP-mediated EMT	10
Dysregulation of adipogenesis and disrupted lipid metabolism by the antidepressants citalopram and sertraline	10
Arsenic trioxide inhibits the functions of lung fibroblasts derived from patients with idiopathic pulmonary fibrosis	10
Editorial Board	10
Development of quercetin-loaded PVCL–PVA–PEG micelles and application in inhibiting tumor angiogenesis through the PI3K/Akt/VEGF pathway	10
Nimbolide attenuated the inflammation in the liver of autoimmune hepatitis's mice through regulation of HDAC3	10
Integrative description of changes occurring on zebrafish embryos exposed to water-soluble crude oil components and its mixture with a chemical surfactant	10
Editorial Board	10
Network pharmacology-based evaluation of natural compounds with paclitaxel for the treatment of metastatic breast cancer	10
Editorial Board	10
Editorial Board	10
Editorial Board	10
Editorial Board	10
Epicatechin exerts dual action to shield sickling and hydroxyurea-induced myelosuppression: Implication in sickle cell anemia management	10
Evaluation of chronic toxicity of cyclocreatine in beagle dogs after oral gavage administration for up to 23 weeks	9
1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via	9
Weight of evidence evaluation of the metabolism disrupting effects of triphenyl phosphate using an expert knowledge elicitation approach	9
SNAI1-expressing fibroblasts and derived-extracellular matrix as mediators of drug resistance in colorectal cancer patients	9
Hainanolide inhibits the progression of colon cancer via inducing the cell cycle arrest, cell apoptosis and activation of the MAPK signaling pathway	9
Proline betaine facilitates angiogenesis in bronchopulmonary dysplasia	9
Elucidating the relationship between metabolites and breast cancer: A Mendelian randomization study	9
Tpl2 kinase regulates inflammation but not tumorigenesis in mice	9
Mercury intoxication disrupts tonic signaling in B cells, and may promote autoimmunity due to abnormal phosphorylation of STIM-1 and other autoimmunity risk associated phosphoproteins involved in BCR	9
Sulforaphane inhibits the migration and invasion of BPDE-induced lung adenocarcinoma cells by regulating NLRP12	9
Deficiency of NLR family member NLRC5 alleviates alcohol induced hepatic injury and steatosis by enhancing autophagy of hepatocytes	9
Chromium distribution in an oropharyngeal aspiration model for hexavalent chromium in rats	9
Baicalin nanoemulsion mitigates cisplatin-induced hepatotoxicity by alleviating oxidative stress, inflammation, and restoring cellular integrity	9
The role of NUPR1 in response to stress and cancer development	9
Dihydromyricetin attenuates cisplatin-induced acute kidney injury by reducing oxidative stress, inflammation and ferroptosis	9
Identification of novel and potential PPARγ stimulators as repurposed drugs for MCAO associated brain degeneration	9
Corrigendum to “PKC-δ-dependent mitochondrial ROS attenuation is involved as 9-OAHSA combats lipoapotosis in rat hepatocytes induced by palmitic acid and in Syrian hamsters induced by high-fat high-ch	9
Association of urinary arsenic, polycyclic aromatic hydrocarbons, and metals with cancers among the female population in the US	9
Effects of tyrosine kinase inhibitors on androgen, estrogen α, glucocorticoid and thyroid receptors	9
Effect of aripiprazole on neural tube development in early chick embryos	9
Corrigendum to “Di-(2-ethylhexyl) phthalate could disrupt the insulin signaling pathway in liver of SD rats and L02 cells via PPARγ” [ Toxicol Appl Pharmacol. 2017; 316:17-26. doi:10.1016/j. taap.2016	9
Isonardosinone attenuates osteoclastogenesis and OVX-induced bone loss via the MAPK/NF-κB pathway	9
Crosstalk between autophagy and inflammasomes in ricin-induced inflammatory injury	9
The ABCB1 and ABCG2 efflux transporters limit brain disposition of the SYK inhibitors entospletinib and lanraplenib	9
Neuroprotective effects of ibudilast against tacrolimus induced neurotoxicity	9
Lupeol, an androgen receptor inhibitor, enhances the chemosensitivity of prostate cancer stem cells to antiandrogen enzalutamide-based therapy	9
Paricalcitol, an active vitamin D analog, mitigates dexamethasone-induced hepatic injury: Role of autophagy, pyroptosis, and PERK/Nrf2/HO-1 signaling pathway	9
Epigallocatechin gallate ameliorates retinal pigment epithelial cell damage via the CYFIP2 /AKT pathway	9
Editorial Board	9
Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or KATP channels inhibitors	9
Zinc supplementation prevents mitotic accumulation in human keratinocyte cell lines upon environmentally relevant arsenic exposure	9
Selective modulation of placental and fetal MDR transporters by chronic in utero exposure to NRTIs in Sprague-Dawley rats: Importance for fetoprotection	9