Toxicology and Applied Pharmacology

Article	Citations
Antimony and its compounds: Health impacts related to pulmonary toxicity, cancer, and genotoxicity	64
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways	61
Edible plant-derived exosomal microRNAs: Exploiting a cross-kingdom regulatory mechanism for targeting SARS-CoV-2	60
Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet	55
Arsenic-induced changes in miRNA expression in cancer and other diseases	54
Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis	49
Exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood disrupts hormones and ovarian folliculogenesis throughout the prime reproductive life of the mouse	48
In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen recept	47
Octreotide and melatonin alleviate inflammasome-induced pyroptosis through inhibition of TLR4-NF-κB-NLRP3 pathway in hepatic ischemia/reperfusion injury	47
Melatonin alleviates doxorubicin-induced mitochondrial oxidative damage and ferroptosis in cardiomyocytes by regulating YAP expression	43
Gambogenic acid induces ferroptosis in melanoma cells undergoing epithelial-to-mesenchymal transition	41
Exposure to low doses of inorganic arsenic induces transgenerational changes on behavioral and epigenetic markers in zebrafish (Danio rerio)	40
Delivery of oxaliplatin to colorectal cancer cells by folate-targeted UiO-66-NH2	39
Induction of apoptosis in breast cancer cells by naphthylisoquinoline alkaloids	37
The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat	36
Reducing the antigen-independent toxicity of antibody-drug conjugates by minimizing their non-specific clearance through PEGylation	35
4-methylpyrazole protects against acetaminophen-induced acute kidney injury	34
Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuro	34
Vildagliptin, a DPP-4 inhibitor, attenuates carbon tetrachloride-induced liver fibrosis by targeting ERK1/2, p38α, and NF-κB signaling	33
Perfluorooctanesulfonic acid (PFOS) administration shifts the hepatic proteome and augments dietary outcomes related to hepatic steatosis in mice	31
Effects of an environmentally relevant PFAS mixture on dopamine and steroid hormone levels in exposed mice	31
Menthol in electronic cigarettes: A contributor to respiratory disease?	30
Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPARα mice fed an American diet	30
TGF-β1-induced EMT activation via both Smad-dependent and MAPK signaling pathways in Cu-induced pulmonary fibrosis	30
Berberine attenuates severity of chronic pancreatitis and fibrosis via AMPK-mediated inhibition of TGF-β1/Smad signaling and M2 polarization	30

Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction	30
Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis	29
Implications for prenatal cadmium exposure and adverse health outcomes in adulthood	28
Celastrol augments sensitivity of NLRP3 to CP-456773 by modulating HSP-90 and inducing autophagy in dextran sodium sulphate-induced colitis in rats	28
Balance between the toxicity and anticancer activity of arsenic trioxide in treatment of acute promyelocytic leukemia	28
Chronic acrylamide exposure induced glia cell activation, NLRP3 infl-ammasome upregulation and cognitive impairment	28
Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis	28
Irisin lowers blood pressure by activating the Nrf2 signaling pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats	27
(−)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD	27
Arsenic-protein interactions as a mechanism of arsenic toxicity	26
Cadmium induced inflammation and apoptosis of porcine epididymis via activating RAF1/MEK/ERK and NF-κB pathways	26
A transcriptomic overview of lung and liver changes one day after pulmonary exposure to graphene and graphene oxide	26
Natural products in the reprogramming of cancer epigenetics	26
Health disparities: Intracellular consequences of social determinants of health	25
Molecular and clinical insights of matrix metalloproteinases into cancer spread and potential therapeutic interventions	25
Low dose spironolactone-mediated androgen-adiponectin modulation alleviates endocrine-metabolic disturbances in letrozole-induced PCOS	25
Montelukast ameliorates Concanavalin A-induced autoimmune hepatitis in mice via inhibiting TNF-α/JNK signaling pathway	25
Targeting autophagy by natural product Ursolic acid for prevention and treatment of osteoporosis	25
Organophosphate ester tri-o-cresyl phosphate interacts with estrogen receptor α in MCF-7 breast cancer cells promoting cancer growth	25
Resveratrol protects against PM2.5-induced heart defects in zebrafish embryos as an antioxidant rather than as an AHR antagonist	25
Endocrine-disrupting chemicals rapidly affect intercellular signaling in Leydig cells	25
Arsenic-induced lung inflammation and fibrosis in a rat model: Contribution of the HMGB1/RAGE, PI3K/AKT, and TGF-β1/SMAD pathways	25
Role of long non-coding RNAs and MYC interaction in cancer metastasis: A possible target for therapeutic intervention	24
Generating adverse outcome pathway (AOP) of inorganic arsenic-induced adult male reproductive impairment via integration of phenotypic analysis in comparative toxicogenomics database (CTD) and AOP wik	24
Sulforaphane inhibits blue light–induced inflammation and apoptosis by upregulating the SIRT1/PGC-1α/Nrf2 pathway and autophagy in retinal pigment epithelial cells	24
A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm	24
Exposures to uranium and arsenic alter intraepithelial and innate immune cells in the small intestine of male and female mice	23
Cisplatin induces autophagy-associated apoptosis in human oral squamous cell carcinoma (OSCC) mediated in part through reactive oxygen species	23
Benzyl isothiocyanate ameliorates high-fat/cholesterol/cholic acid diet-induced nonalcoholic steatohepatitis through inhibiting cholesterol crystal-activated NLRP3 inflammasome in Kupffer cells	23
Activation of the Erk/MAPK signaling pathway is a driver for cadmium induced prostate cancer	22
Cardiac toxicity from bisphenol A exposure in human-induced pluripotent stem cell-derived cardiomyocytes	22
Ovatodiolide, isolated from Anisomeles indica, suppresses bladder carcinogenesis through suppression of mTOR/β-catenin/CDK6 and exosomal miR-21 derived from M2 tumor-associated macrophages	22
Calcitriol ameliorated autonomic dysfunction and hypertension by down-regulating inflammation and oxidative stress in the paraventricular nucleus of SHR	22
Nitrofuran drugs beyond redox cycling: Evidence of Nitroreduction-independent cytotoxicity mechanism	22
Zebrafish early life stages as alternative model to study ‘designer drugs’: Concordance with mammals in response to opioids	21
Effects of lithium on cytokine neuro-inflammatory mediators, Wnt/β-catenin signaling and microglial activation in the hippocampus of chronic mild stress-exposed rats	21
Comparative analysis of the physicochemical, toxicokinetic, and toxicological properties of ether-PFAS	21
Nano selenium protects against deltamethrin-induced reproductive toxicity in male rats	21
Pulmonary toxicants and fibrosis: innate and adaptive immune mechanisms	21
Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways	21
Effects of environmental and occupational lead toxicity and its association with iron metabolism	21
Amentoflavone prevents ox-LDL-induced lipid accumulation by suppressing the PPARγ/CD36 signal pathway	21
Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes	21
Oxytetracycline induces anxiety-like behavior in adult zebrafish	20
Cognitive enhancing effect of diapocynin in D-galactose-ovariectomy-induced Alzheimer's-like disease in rats: Role of ERK, GSK-3β, and JNK signaling	20
Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment	20
Minocycline prevents neuronal hyperexcitability and neuroinflammation in medial prefrontal cortex, as well as memory impairment caused by repeated toluene inhalation in adolescent rats	20
Angiogenesis signaling in breast cancer models is induced by hexachlorobenzene and chlorpyrifos, pesticide ligands of the aryl hydrocarbon receptor	19
MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf2	19
Dual targeting of EZH2 and androgen receptor as a novel therapy for castration-resistant prostate cancer	19

NLRC5 negatively regulates inflammatory responses in LPS-induced acute lung injury through NF-κB and p38 MAPK signal pathways	19
Paris saponin II-induced paraptosis-associated cell death increased the sensitivity of cisplatin	19
Upregulation of ubiquitinated proteins and their degradation pathway in muscle atrophy induced by cisplatin in mice	19
miR-148a/LDLR mediates hypercholesterolemia induced by prenatal dexamethasone exposure in male offspring rats	19
Curcumin ameliorates hypertension via gut-brain communication in spontaneously hypertensive rat	19
Polyphyllin I reverses the resistance of osimertinib in non-small cell lung cancer cell through regulation of PI3K/Akt signaling	19
Network pharmacology and molecular docking analysis on molecular targets: Mechanisms of baicalin and baicalein against hyperuricemic nephropathy	19
Oxymatrine ameliorates imiquimod-induced psoriasis pruritus and inflammation through inhibiting heat shock protein 90 and heat shock protein 60 expression in keratinocytes	19
Arsenic induced redox imbalance triggers the unfolded protein response in the liver of zebrafish	18
Lactobacillus rhamnosus GG combined with inosine ameliorates alcohol-induced liver injury through regulation of intestinal barrier and Treg/Th1 cells	18
Targeting CD166+ lung cancer stem cells: Molecular study using murine dendritic cell vaccine	18
Irinotecan-mediated diarrhea is mainly correlated with intestinal exposure to SN-38: Critical role of gut Ugt	18
Ovarian mitochondrial and oxidative stress proteins are altered by glyphosate exposure in mice	18
SPP1 derived from silica-exposed macrophage exosomes triggers fibroblast transdifferentiation	18
Thymol activates TRPM8-mediated Ca2+ influx for its antipruritic effects and alleviates inflammatory response in Imiquimod-induced mice	18
The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice	18
Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/β-catenin, AMPK/mTOR signaling pathways	18
Chloroquine may induce endothelial injury through lysosomal dysfunction and oxidative stress	18
Food emulsifier polysorbate 80 promotes the intestinal absorption of mono-2-ethylhexyl phthalate by disturbing intestinal barrier	18
Improved bioavailability and anticancer efficacy of Hesperetin on breast cancer via a self-assembled rebaudioside A nanomicelles system	18
The interrupted cross-talk of inflammatory and oxidative stress trajectories signifies the effect of artesunate against hepatic ischemia/reperfusion-induced inflammasomopathy	18
Physalin A attenuates inflammation through down-regulating c-Jun NH2 kinase phosphorylation/Activator Protein 1 activation and up-regulating the antioxidant activity	18
Heart slice culture system reliably demonstrates clinical drug-related cardiotoxicity	18
Multi and transgenerational epigenetic effects of di-(2-ethylhexyl) phthalate (DEHP) in liver	18
Prepubertal exposure to arsenic alters male reproductive parameters in pubertal and adult rats	18
Suppression of iron mobilization from lysosomes to mitochondria attenuates liver injury after acetaminophen overdose in vivo in mice: Protection by minocycline	18
Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells	17
Hydrogen sulfide attenuates postoperative cognitive dysfunction through promoting the pathway of Warburg effect-synaptic plasticity in hippocampus	17
The protective mechanism of resveratrol against hepatic injury induced by iron overload in mice	17
Inorganic arsenic and its methylated metabolites as endocrine disruptors in the placenta: Mechanisms underpinning glucocorticoid receptor (GR) pathway perturbations	17
Diosgenin alleviates hypercholesterolemia via SRB1/CES-1/CYP7A1/FXR pathway in high-fat diet-fed rats	17
Daphnetin ameliorates glucocorticoid-induced osteoporosis via activation of Wnt/GSK-3β/β-catenin signaling	17
Remdesivir; molecular and functional measures of mitochondrial safety	17
Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil	17
Apigenin alleviates cancer drug Sorafenib induced multiple toxic effects in Swiss albino mice via anti-oxidative stress	17
NURA: A curated dataset of nuclear receptor modulators	17
Acute and chronic vascular effects of inhaled crotonaldehyde in mice: Role of TRPA1	17
Targeting lung cancer stem cells using combination of Tel and Docetaxel liposomes in 3D cultures and tumor xenografts	17
Integrated transcriptomic and metabolomic analyses to characterize the anti-cancer effects of (−)-epigallocatechin-3-gallate in human colon cancer cells	17
Exposure to alternative bisphenols BPS and BPF through breast milk: Noxious heritage effect during nursing associated with idiopathic infertility	16
CoQ10 protects against acetaminophen-induced liver injury by enhancing mitophagy	16
Casticin inhibits stemness of hepatocellular carcinoma cells via disrupting the reciprocal negative regulation between DNMT1 and miR-148a-3p	16
A systematic review of clinical and laboratory findings of lead poisoning: lessons from case reports	16
Ligustilide inhibits the proliferation of non-small cell lung cancer via glycolytic metabolism	16
Gut microbiome in neuroendocrine and neuroimmune interactions: The case of genistein	16
C-myc promotes miR-92a-2-5p transcription in rat ovarian granulosa cells after cadmium exposure	16
The selective c-Met inhibitor capmatinib offsets cisplatin-nephrotoxicity and doxorubicin-cardiotoxicity and improves their anticancer efficacies	16
Breast cancer cells-derived Von Willebrand Factor promotes VEGF-A-related angiogenesis through PI3K/Akt-miR-205-5p signaling pathway	16
T helper 2-driven immune dysfunction in chronic arsenic-exposed individuals and its link to the features of allergic asthma	16
Astaxanthin attenuates alcoholic cardiomyopathy via inhibition of endoplasmic reticulum stress-mediated cardiac apoptosis	16
Metabolomic-based assessment reveals dysregulation of lipid profiles in human liver cells exposed to environmental obesogens	16
Crocin induces ROS-mediated papillary thyroid cancer cell apoptosis by modulating the miR-34a-5p/PTPN4 axis in vitro	15
Safety assessment of drug combinations used in COVID-19 treatment: in silico toxicogenomic data-mining approach	15
Molecular docking analyses of Escin as regards cyclophosphamide-induced cardiotoxicity: In vivo and in Silico studies	15
Ononin alleviates endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity by activating SIRT3	15
Isorhynchophylline ameliorates paraquat-induced acute kidney injury by attenuating oxidative stress and mitochondrial damage via regulating toll-interacting expression	15
Co-exposure to PCB126 and PFOS increases biomarkers associated with cardiovascular disease risk and liver injury in mice	15
A QSAR study that compares the ability of bisdioxopiperazine analogs of the doxorubicin cardioprotective agent dexrazoxane (ICRF-187) to protect myocytes with DNA topoisomerase II inhibition	15
Synergistic action of organophosphates and COVID-19 on inflammation, oxidative stress, and renin-angiotensin system can amplify the risk of cardiovascular maladies	15
A network pharmacology approach to investigate the anticancer mechanism of cinobufagin against hepatocellular carcinoma via downregulation of EGFR-CDK2 signaling	15
Astrocytic Kir4.1 regulates NMDAR/calpain signaling axis in lipopolysaccharide-induced depression-like behaviors in mice	15
Dexamethasone inhibits pancreatic tumor growth in preclinical models: Involvement of activating glucocorticoid receptor	15
Natural alkaloid 8-oxo-epiberberine inhibited TGF-β1-triggred epithelial-mesenchymal transition by interfering Smad3	15
Diosmin ameliorates inflammation, insulin resistance, and fibrosis in an experimental model of non-alcoholic steatohepatitis in rats	15
Linagliptin ameliorates acetic acid-induced colitis via modulating AMPK/SIRT1/PGC-1α and JAK2/STAT3 signaling pathway in rats	15
Ozone-induced changes in oxidative stress parameters in brain regions of adult, middle-age, and senescent Brown Norway rats	15
Arsenic trioxide-induced p38 MAPK and Akt mediated MCL1 downregulation causes apoptosis of BCR-ABL1-positive leukemia cells	15
Thyroid disruption and developmental toxicity caused by triphenyltin (TPT) in zebrafish embryos/larvae	15
Methamphetamine induces intestinal injury by altering gut microbiota and promoting inflammation in mice	14
Andrographolide inhibits IL-1β release in bone marrow-derived macrophages and monocyte infiltration in mouse knee joints induced by monosodium urate	14
U0126 pretreatment inhibits cisplatin-induced apoptosis and autophagy in HEI-OC1 cells and cochlear hair cells	14
Pharmacological postconditioning with sappanone A ameliorates myocardial ischemia reperfusion injury and mitochondrial dysfunction via AMPK-mediated mitochondrial quality control	14
IL-8 and MCP-1/CCL2 regulate proteolytic activity in triple negative inflammatory breast cancer a mechanism that might be modulated by Src and Erk1/2	14
Development of quercetin-loaded PVCL–PVA–PEG micelles and application in inhibiting tumor angiogenesis through the PI3K/Akt/VEGF pathway	14
Chronic arsenic exposure enhances metastatic potential via NRF2-mediated upregulation of SOX9	14
Melatonin's efficacy in stroke patients; a matter of dose? A systematic review	14
Curcumin alleviates arsenic-induced injury in duck skeletal muscle via regulating the PINK1/Parkin pathway and protecting mitochondrial function	14
Developmental arsenic exposure induces dysbiosis of gut microbiota and disruption of plasma metabolites in mice	14
Low dose lead exposure at the onset of puberty disrupts spermatogenesis-related gene expression and causes abnormal spermatogenesis in mouse	14
Toxicity analysis of endocrine disrupting pesticides on non-target organisms: A critical analysis on toxicity mechanisms	14

Orlistat delays hepatocarcinogenesis in mice with hepatic co-activation of AKT and c-Met	14
Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway	14
Aldehyde dehydrogenase-2 activation decreases acetaminophen hepatotoxicity by prevention of mitochondrial depolarization	14
HepG2 (C3A) spheroids show higher sensitivity compared to HepaRG spheroids for drug-induced liver injury (DILI)	14
Bisphenolic compounds alter gene expression in MCF-7 cells through interaction with estrogen receptor α	14
Ethyl maltol enhances copper mediated cytotoxicity in lung epithelial cells	14
Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress	14
Effects of silver nanoparticles on T98G human glioblastoma cells	14
Biological effects of inhaled hydraulic fracturing sand dust. III. Cytotoxicity and pro-inflammatory responses in cultured murine macrophage cells	14
Triclosan disrupts immune cell function by depressing Ca2+ influx following acidification of the cytoplasm	13
S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs	13
Environmental exposure to volatile organic compounds is associated with endothelial injury	13
Hesperetin protects against palmitate-induced cellular toxicity via induction of GRP78 in hepatocytes	13
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats	13
Hydrogen sulfide attenuates induction and prevents progress of the 6-hydroxydopamine-induced Parkinsonism in rat through activation of ATP-sensitive potassium channels and suppression of ER stress	13
Role of the PI3K/Akt pathway in cadmium induced malignant transformation of normal prostate epithelial cells	13
Comparative physiology and efficacy of atropine and scopolamine in sarin nerve agent poisoning	13
Gut microbiome-host interactions in driving environmental pollutant trichloroethene-mediated autoimmunity	13
Resveratrol and its nanocrystals: A promising approach for cancer therapy?	13
Time-to-treatment window and cross-sex potential of β2-adrenergic receptor-induced mitochondrial biogenesis-mediated recovery after spinal cord injury	13
Down-regulation of lncRNA MEG3 promotes chronic low dose cadmium exposure-induced cell transformation and cancer stem cell-like property	13
Resveratrol ameliorates lipopolysaccharide-induced anxiety-like behavior by attenuating YAP-mediated neuro-inflammation and promoting hippocampal autophagy in mice	13
Apple polyphenol phloretin complexed with ruthenium is capable of reprogramming the breast cancer microenvironment through modulation of PI3K/Akt/mTOR/VEGF pathways	13
Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition	13
Preclinical toxicology profile of squalene epoxidase inhibitors	13
The circadian clock protects against acute radiation-induced dermatitis	13
MST2 silencing induces apoptosis and inhibits tumor growth for estrogen receptor alpha-positive MCF-7 breast cancer	13
Forsythoside A inhibits adhesion and migration of monocytes to type II alveolar epithelial cells in lipopolysaccharide-induced acute lung injury through upregulating miR-124	12
Epidermal Growth Factor-labeled liposomes as a way to target the toxicity of silver nanoparticles into EGFR-overexpressing cancer cells in vitro	12
Arsenic metabolism differs between child and adult patients during acute arsenic poisoning	12
Metabolic profile of methylazoxymethanol model of schizophrenia in rats and effects of three antipsychotics in long-acting formulation	12
Integrative systems toxicology to predict human biological systems affected by exposure to environmental chemicals	12
OroxylinA reverses lipopolysaccharide-induced adhesion molecule expression and endothelial barrier disruption in the rat aorta	12
The Aryl hydrocarbon receptor mediates reproductive toxicity of polychlorinated biphenyl congener 126 in rats	12
Chronic cannabidiol treatment reduces the carbachol-induced coronary constriction and left ventricular cardiomyocyte width of the isolated hypertensive rat heart	12
The SMAC mimetic LCL161 is a direct ABCB1/MDR1-ATPase activity modulator and BIRC5/Survivin expression down-regulator in cancer cells	12
Demyelination associated with chronic arsenic exposure in Wistar rats	12
In silico, in vitro and in vivo evaluation of natural Bignoniaceous naphthoquinones in comparison with atovaquone targeting the selection of potential antimalarial candidates	12
Maternal-fetal disposition of domoic acid following repeated oral dosing during pregnancy in nonhuman primate	12
Mitoglitazone ameliorates renal ischemia/reperfusion injury by inhibiting ferroptosis via targeting mitoNEET	12
Species-specific differences in the inhibition of 11β-hydroxysteroid dehydrogenase 2 by itraconazole and posaconazole	12
Effect of dexamethasone treatment at variable therapeutic windows in reversing nitrogen mustard-induced corneal injuries in rabbit ocular in vivo model	12
Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat	12
Cetylpyridinium chloride (CPC) reduces zebrafish mortality from influenza infection: Super-resolution microscopy reveals CPC interference with multiple protein interactions with phosphatidylinositol 4	12
Biological effects of inhaled hydraulic fracturing sand dust. VIII. Immunotoxicity	12
PCC0208023, a potent SHP2 allosteric inhibitor, imparts an antitumor effect against KRAS mutant colorectal cancer	12
Titanium dioxide nanoparticles induced reactive oxygen species (ROS) related changes of metabolomics signatures in human normal bronchial epithelial (BEAS-2B) cells	12
Final results from a 90-day quantitative inhalation toxicology study evaluating the dose-response and fate in the lung and pleura of chrysotile-containing brake dust compared to TiO2, chrysotile, croc	12
Involvement of endoplasmic reticulum stress-activated PERK-eIF2α-ATF4 signaling pathway in T-2 toxin-induced apoptosis of porcine renal epithelial cells	12
MiR-122-5p increases radiosensitivity and aggravates radiation-induced rectal injury through CCAR1	12
Crotonaldehyde-induced vascular relaxation and toxicity: Role of endothelium and transient receptor potential ankyrin-1 (TRPA1)	12
Anemoside A3 activates TLR4-dependent M1-phenotype macrophage polarization to represses breast tumor growth and angiogenesis	12
Effects of dapagliflozin and statins attenuate renal injury and liver steatosis in high-fat/high-fructose diet-induced insulin resistant rats	12
Liver-specific Nrf2 deficiency accelerates ethanol-induced lethality and hepatic injury in vivo	11
Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-κB activation	11
Crosstalk between gut microbiota and lung inflammation in murine toxicity models of respiratory exposure or co-exposure to carbon nanotube particles and cigarette smoke extract	11
Vitamin D supplementation rescues simvastatin induced myopathy in mice via improving mitochondrial cristae shape	11
Mechanism of hepatobiliary toxicity of the LPA1 antagonist BMS-986020 developed to treat idiopathic pulmonary fibrosis: Contrasts with BMS-986234 and BMS-986278	11
Biological effects of inhaled hydraulic fracturing sand dust. VI. Cardiovascular effects	11
Arsenic trioxide disturbs the LIS1/NDEL1/dynein microtubule dynamic complex by disrupting the CLIP170 zinc finger in head and neck cancer	11
Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma by blocking Wnt/β-catenin/STAT3 axis	11
An inclusive outlook on the fate and persistence of pesticides in the environment and integrated eco-technologies for their degradation	11
Maltotriose-modified poly(propylene imine) Glycodendrimers as a potential novel platform in the treatment of chronic lymphocytic Leukemia. A proof-of-concept pilot study in the animal model of CLL	11
Arsenic exposure in drinking water reduces Lgr5 and secretory cell marker gene expression in mouse intestines	11
Synthetic cannabinoids enhanced ethanol-induced motor impairments through reduction of central glutamate neurotransmission	11
Elucidation of OATP1B1 and 1B3 transporter function using transgenic rodent models and commonly known single nucleotide polymorphisms	11
Biological effects of inhaled hydraulic fracturing sand dust. IV. Pulmonary effects	11
LncRNA Mical2/miR-203a-3p sponge participates in epithelial-mesenchymal transition by targeting p66Shc in liver fibrosis	11
Long non-coding RNA CYTOR modulates cancer progression through miR-136-5p/MAT2B axis in renal cell carcinoma	11
Malformations and mortality in zebrafish early stages associated with elevated caspase activity after 24 h exposure to MS-222	11
Arsenic induced epigenetic changes and relevance to treatment of acute promyelocytic leukemia and beyond	11
Chronic arsenic exposure suppresses ATM pathway activation in human keratinocytes	11
Female-specific activation of pregnane X receptor mediates sex difference in fetal hepatotoxicity by prenatal monocrotaline exposure	11
Elevated whole blood arsenic level is associated with type 2 diabetes in coal-burning areas in Guizhou	11
Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation	11
Effects of classic antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish	11
Di-(2-ethylhexyl) phthalate inhibits expression and internalization of transthyretin in human placental trophoblastic cells	11
Metformin leads to accumulation of reactive oxygen species by inhibiting the NFE2L1 expression in human hepatocellular carcinoma cells	11
Metformin relieves H/R-induced cardiomyocyte injury through miR-19a/ACSL axis - possible therapeutic target for myocardial I/R injury	11
ATP and ADP enhance DNA damage repair in γ-irradiated BEAS-2B human bronchial epithelial cells through activation of P2X7 and P2Y12 receptors	11
Role of ferroptosis in promoting cardiotoxicity induced by Imatinib Mesylate via down-regulating Nrf2 pathways in vitro and in vivo	11
Catalpol induces apoptosis in breast cancer in vitro and in vivo: Involvement of mitochondria apoptosis pathway and post-translational modifications	10
Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells	10
Whole life exposure to low dose cadmium alters diet-induced NAFLD	10
Identification of four methylation-driven genes as candidate biomarkers for monitoring single-walled carbon nanotube-induced malignant transformation of the lung	10
Ovariectomy provokes inflammatory and cardiovascular effects of endotoxemia in rats: Dissimilar benefits of hormonal supplements	10
Mechanism-based integrated assay systems for the prediction of drug-induced liver injury	10
Schisandrin B induces HepG2 cells pyroptosis by activating NK cells mediated anti-tumor immunity	10
Investigating DNA adduct formation by flavor chemicals and tobacco byproducts in electronic nicotine delivery system (ENDS) using in silico approaches	10
Towards a comprehensive safety understanding of granulocyte-colony stimulating factor biosimilars in treating chemotherapy associated febrile neutropenia: Trends from decades of data	10
Enzyme-sensitive nanoparticles, smart TAT and cetuximab conjugated immunoliposomes to overcome multidrug resistance in breast cancer cells	10
Empagliflozin dilates the rabbit aorta by activating PKG and voltage-dependent K+ channels	10
Predicting changes in renal metabolism after compound exposure with a genome-scale metabolic model	10
Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio	10
Pegbelfermin, a PEGylated FGF21 analogue, has pharmacology without bone toxicity after 1-year dosing in skeletally-mature monkeys	10