Toxicology and Applied Pharmacology

Article	Citations
Editorial Board	152
Nrf2 deficiency aggravates hepatic cadmium accumulation, inflammatory response and subsequent injury induced by chronic cadmium exposure in mice	81
Mitochondrial iron deficiency mediated inhibition of ecdysone synthesis underlies lead (Pb) induced developmental toxicity in Drosophila melanogaster	62
Anti-NOTCH1 therapy with OMP-52 M51 inhibits salivary adenoid cystic carcinoma by depressing epithelial-mesenchymal transition (EMT) process and inducing ferroptosis	60
Clarithromycin attenuates severe steroid hyporesponsive asthma by regulating type 2/type 17 inflammation balance and inhibiting mast cell activation	51
Neuregulin 1 improved gastric motility and reduced gastric inflammation by activating the α7nAChR through the cholinergic anti-inflammatory pathway in diabetic rats	50
Editorial Board	49
Raddeanin A synergistically enhances the anti-tumor effect of MAP30 in multiple ways, more than promoting endosomal escape	47
Exploring the mechanism of baicalein on breast cancer based on network pharmacology, molecular docking and in vivo experiments	46
Integrated analysis of microRNA expression profiles and function network in mice testes after low dose lead exposure from early puberty	46
Infection and disruption of placental multidrug resistance (MDR) transporters: Implications for fetal drug exposure	45
Serum levels of IL-6/IL-10/GLDH may be early recognition markers of anti-tuberculosis drugs (ATB) -induced liver injury	44
Establishment of baseline profiles of 50 bile acids in preclinical toxicity species: A comprehensive assessment of translational differences and study design considerations for biomarker development	42
Berberine alleviated contrast-induced acute kidney injury by mitophagy-mediated NLRP3 inflammasome inactivation in a mice model	41
Liposomal methemoglobin as a potent antidote for hydrogen sulfide poisoning	39
Curcumin induces apoptosis via downregulation of SKP2 and induction of GADD45A/CDKN1A expression through generation of ROS in cutaneous T-cell lymphoma cells	39
Application of Cell Painting for chemical hazard evaluation in support of screening-level chemical assessments	37
Lonicerin protects pancreatic acinar cells from caerulein-induced apoptosis, inflammation, and ferroptosis by activating the SIRT1/GPX4 signaling pathway	37
Towards translating in vitro measures of thyroid hormone system disruption to in vivo responses in the pregnant rat via a biologically based dose response (BBDR) model	37
Epigenetic modifications control CYP1A1 Inducibility in human and rat keratinocytes	37
Ferritinophagy-derived iron causes protein nitration and mitochondrial dysfunction in acetaminophen-induced liver injury	35
circSHOC1-SLC25A3 promotes 2-naphthylamine-induced DNA damage in bronchial epithelial cells via activation of oxidative stress	32
Palmitic acid and lipopolysaccharide induce macrophage TNFα secretion, suppressing browning regulators and mitochondrial respiration in adipocytes	32
Role of microbial microbes in arsenic bioaccumulation and biotransformation in mice	32
Assessing the effects of silver nanoparticles on ARPE-19 cells via high-throughput phenotypic profiling with the Cell Painting assay	31

Cardiorespiratory failure and sudden death induced by carfentanil exposure: Involvement of central mu1 opioid receptors	30
Integrative analysis of metabolomics and proteomics reveals mechanism of berberrubine-induced nephrotoxicity	29
Mitochondrial dysfunction-associated cellular senescence is partially involved in bleomycin-induced pulmonary fibrosis in mice	29
Mitoglitazone ameliorates renal ischemia/reperfusion injury by inhibiting ferroptosis via targeting mitoNEET	29
Safety assessment on CBD-rich hemp extract in sub-chronic cross-sex study with rats	28
Apigenin alleviates cancer drug Sorafenib induced multiple toxic effects in Swiss albino mice via anti-oxidative stress	28
Azoospermia and multi-organ damage in juvenile rats exposed to α-Terpineol from weaning to sexual maturity	28
Synergistic anticancer effects of ginsenoside CK and gefitinib against gefitinib-resistant NSCLC by regulating the balance of angiogenic factors through HIF-1α/VEGF	28
The therapeutic effect of hesperetin on doxorubicin-induced testicular toxicity: Potential roles of the mechanistic target of rapamycin kinase (mTOR) and dynamin-related protein 1 (DRP1)	28
Ameliorative effect of nano-pregabalin in gastrocnemius muscle of gamma irradiated rats with an experimental model of fibromyalgia: Crosstalk of Sirt3, IL-1β and PARP1 pathways	27
Neonatal exposure to an environmentally relevant phthalate mixture alters ovarian function in mice	27
Cadmium alters the cellular metabolome of human ovarian granulosa cells	27
Hexavalent chromium increases the metabolism and genotoxicity of aromatic amine carcinogens 4-aminobiphenyl and β-naphthylamine in immortalized human lung epithelial cells	27
Prenatal exposure to arsenic promotes sterile inflammation through the Polycomb repressive element EZH2 and accelerates skin tumorigenesis in mouse	26
Effect of parental perinatal exposure to L-glutamate monosodium salt monohydrate on developmental neurotoxicity in rat offspring	26
Toxic element contaminations of prenatal vitamins	26
Redox aspects of cytotoxicity and anti-neuroinflammatory profile of chloroquine and hydroxychloroquine in serum-starved BV-2 microglia	26
A rational approach to assess off-target reactivity of a dual-signal integrator for T cell therapy	25
Reproductive tissue toxicity of deoxynivalenol and α-zearalenol alone or in combination: Insights from a porcine explant model	25
The myosin II inhibitor, blebbistatin, ameliorates pulmonary endothelial barrier dysfunction in acute lung injury induced by LPS via NMMHC IIA/Wnt5a/β-catenin pathway	25
Effects of anti-tuberculosis drugs on the proliferation and differentiation of alveolar stem cells	25
Editorial Board	24
Curcumin alleviated dextran sulfate sodium-induced ulcerative colitis via inhibition of the Wnt/β-catenin signaling pathway and regulation of the differentiation of intestinal stem cells	24
Toxicological and biochemical mechanisms of pesticides in non-targeted biological systems	24
Hepatic biotransformation of non-psychotropic phytocannabinoids and activity screening on cytochromes P450 and UDP-glucuronosyltransferases	24
Evaluation of dermal toxicity and toxicokinetics of povidone‑iodine in Göttingen minipigs	24
Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data	24
Methionine redox regulation of actin-interacting proteins primarily governs antioxidative signaling and response to the salvianolic acid B treatment in EA.hy926 cells	23
Neuroprotective effects of saxagliptin against radiation-induced cognitive impairment: Insights on Akt/CREB/SIRT1/BDNF signaling pathway	23
Toxic effects of prenatal azithromycin exposure on fetal adrenal gland in mice: The role of stage, dose and course of treatment	23
Editorial Board	23
Cardiac inotropy and cardiac calcium sensitization of PanLN800(-Forte), a cationic heptamethine indocyanine fluorescent contrast agent for intraoperative pan lymph node imaging	23
An experimental evaluation of the efficacy of perinatal sulforaphane supplementation to decrease the incidence and severity of vinclozolin-induced hypospadias in the mouse model	23
Corrigendum to “Co-delivery of celastrol and lutein with pH sensitive nano micelles for treating acute kidney injury” [Toxicology and Applied Pharmacology Volume 450, 1 September 2022, 116155]	23
Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus L.) exerts multidirectional pro-healing properties towards damaged zebrafish hair cells by regulating the innate immune response	22
Glyphosate-based herbicide causes spermatogenesis disorder and spermatozoa damage of the Chinese mitten crab (Eriocheir sinensis) by affecting testes characteristic enzymes, antioxidant capacities and	22
The interaction between Hsp90-mediated unfolded protein response and autophagy contributes to As3+/ Se4+ combination-induced apoptosis of acute promyelocytic leukemia cells	22
Thiostrepton suppresses colorectal cancer progression through reactive oxygen species related endoplasmic reticulum stress	22
In utero di-(2-ethylhexyl) phthalate-induced testicular dysgenesis syndrome in male newborn rats is rescued by taxifolin through reducing oxidative stress	22
Subacute exposure to Roundup® changes steroidogenesis and gene expression of the glutathione-glutaredoxin system in rat ovaries: Implications for ovarian toxicity of this glyphosate-based herbicide	22
Kaempferol and ginsenoside Rg1 ameliorate acute hypobaric hypoxia induced lung injury based on network pharmacology analysis	22
Scorpion venom peptide S6540 induces caspase-independent apoptosis in non-small cell lung cancer A549 cells	22
NRF2-ARE signaling is responsive to haloacetonitrile-induced oxidative stress in human keratinocytes	21
Pinoresinol diglucoside mitigates dexamethasone-induced osteoporosis and chondrodysplasia in zebrafish	20
Repurposing FDA-approved allosteric drugs as non-competitive inhibitors of human UGTs: An integrated computational study and biochemical validation	20
Schisantherin A alleviates hepatotoxicity induced by diosbulbin B in mice via suppressing metabolic activation of diosbulbin B	20
Effects of heated tobacco product aerosol extracts on DNA methylation and gene transcription in lung epithelial cells	19
Editorial Board	19
Hexavalent chromium inhibits myogenic differentiation and induces myotube atrophy	19
The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice	19

A tribute to Scott W. Burchiel, PHD	19
Editorial Board	19
Evaluation of several farnesyloxycarbostyril derivatives as potential 15-LOX-1 inhibitors for prostate cancer treatment	19
Effects of catechin on the malignant biological behavior of gastric cancer cells through the PI3K/Akt signaling pathway	19
Ginsenoside Rg3 attenuates the stemness of breast cancer stem cells by activating the hippo signaling pathway	19
Angiotensin IV ameliorates doxorubicin-induced cardiotoxicity by increasing glutathione peroxidase 4 and alleviating ferroptosis	19
Beneficial effects of metformin supplementation in hypothalamic paraventricular nucleus and arcuate nucleus of type 2 diabetic rats	19
Flame retardant tricresyl phosphate gestational exposure induced endocrine and metabolic disruptions in rat	19
Honokiol ameliorates hepatic fibrosis by inducing lysosomal membrane permeabilization and impairing lipophagy in hepatic stellate cells	19
Modulation of NF-кB/NLRP3 signaling by sitagliptin attenuates cholestatic hepatic fibrosis	18
An improved in vitro model simulating the feto-maternal interface to study developmental effects of potentially toxic compounds: The example of titanium dioxide nanoparticles	18
Carvone attenuates cardiac fibrosis and inflammation by modulating GSK-3β/PKC-α signalling pathway in experimentally induced polycystic ovarian syndrome	18
Integrative analysis of levofloxacin-induced liver injury: Insights from pharmacovigilance, human liver organoids, and extracellular vesicle proteomics	18
Hederagenin exerts anti-tumor effects in pancreatic cancer by impairing DRP1 mediated-mitophagy via VDAC1-HK2-PINK1/PARKIN pathway	18
Lacosamide as a chemoprotective agent beyond anticonvulsant activity: Pharmacological modulation of Notch-1/NF-κB axis to restore antioxidant defense, inhibit apoptosis, and preserve testosterone-andr	18
Linking chemicals, genes and morphological perturbations to diseases	17
Arsenic up-regulates PD-L1 and enhances lung tumorigenesis through activation of STAT3 in alveolar epithelial type 2 cells	17
The hepatic and developmental toxicity of chronic morphine and disulfiram co-treatment for pain relief - a comprehensive in vitro and in vivo assessment	17
Bioinformatics and network pharmacology identify promotional effects and potential mechanisms of ethanol on esophageal squamous cell carcinoma and experimental validation	17
The downregulation of TREM2 exacerbates toxicity of development and neurobehavior induced by aluminum chloride and nano-alumina in adult zebrafish	17
Fudosteine attenuates lung inflammation in mice with PM2.5-induced asthma exacerbation by inhibiting pyroptosis via the NLRP3/caspase-1/GSDMD pathway	17
Prenatal arsenite exposure alters maternal cardiac remodeling during late pregnancy	17
Effects of exposure to the neonicotinoid pesticide clothianidin on mouse intestinal microbiota under unpredictable environmental stress	17
Comparative study of estrogenic activities of phytoestrogens using OECD in vitro and in vivo testing methods	17
The contribution of the neuroendocrine system to adaption after repeated daily ozone exposure in rats	17
PI3K inhibitor “alpelisib” alleviates methotrexate induced liver injury in mice and potentiates its cytotoxic effect against MDA-MB-231 triple negative breast cancer cell line	16
Ononin alleviates endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity by activating SIRT3	16
Resveratrol attenuates atherosclerotic endothelial injury through the Pin1/Notch1 pathway	16
Doxorubicin-induced cardiotoxicity under 28 GHz 5G-band electromagnetic radiation in rats: Insights into the mitigative role of vitamin C	16
Acacetin induces sustained ERK1/2 activation and RIP1-dependent necroptotic death in breast cancer cells	16
Biodistribution and toxicity following a single or repeated pharyngeal aspiration of titanium dioxide nanoparticles: Determination of maximum allowable dose level	16
Evaluation of the distribution and excretion of [14C]-inclisiran following single subcutaneous administration in cynomolgus monkeys	16
β-Sitosterol protects against lithocholic acid-induced hepatotoxicity and cholestasis via farnesoid X receptor-mediated regulation of transporters and enzymes in vitro and in vivo	16
Hesperidin attenuates radiation-induced ovarian failure in rats: Emphasis on TLR-4/NF-ĸB signaling pathway	16
ROS responsive nanozyme loaded with STING silencing for the treatment of sepsis-induced acute lung injury	16
Perfluorooctanoic acid (PFOA) promotes follicular growth and alters expression of genes that regulate the cell cycle and the Hippo pathway in cultured neonatal mouse ovaries	16
Metabolomics of V2O5 nanoparticles and V2O5 nanofibers in human airway epithelial BEAS-2B cells	16
γ-Glutamylcysteine restores glucolipotoxicity-induced islet β-cell apoptosis and dysfunction via inhibiting endoplasmic reticulum stress	16
Cysteine and glycine-rich protein 2 is crucial for maintaining the malignant phenotypes of gliomas through its action on Notch signalling cascade	15
Adrenergic receptor subtypes differentially influence acrolein-induced ventilatory, vascular leakage, and inflammatory responses	15
Fucoxanthin ameliorates ulcerative colitis by maintaining the epithelial barrier via blocking JAK2/STAT3 signaling pathway	15
Can we do better with Mylotarg? Model-based assessment of opportunities to improve therapeutic index	15
Apoptotic mechanism of development inhibition in zebrafish induced by esketamine	15
Vitamin D3 and Salinomycin synergy in MCF-7 cells cause cell death via endoplasmic reticulum stress in monolayer and 3D cell culture	15
Vascular endothelial-derived Von Willebrand factor inhibits lung cancer progression through the αvβ3/ERK1/2 axis	15
Defining high confidence targets of differential CpG methylation in response to in utero arsenic exposure and implications for cancer risk	15
NFE2L2 protects against Sorafenib-induced Ferroptosis and cardiotoxicity by activating the HO1/ferritin pathway	15
Esketamine induces apoptosis of nasopharyngeal carcinoma cells through the PERK/CHOP pathway	15
Arctigenin relieves inflammation and remodels the nasal epithelial barrier function in allergic rhinitis via the KLF5/BIRC3/NFκB axis	15
Lactational transfer of sulforaphane-N-acetylcysteine in vivo and in human breast milk	15
Editorial Board	15
Structure dependence and species sensitivity of in vivo hepatobiliary toxicity with lysophosphatidic acid receptor 1 (LPA1) antagonists	15
Toxicokinetics of mono-(2-ethylhexyl) phthalate with low-dose exposure applying fluorescence tracing technique	15
Zinc supplementation alters tissue distribution of arsenic in Mus musculus	15
Pulmonary inflammation and cellular responses following exposure to benzalkonium chloride: Potential impact of disrupted pulmonary surfactant homeostasis	14
Editorial Board	14
Levocabastine ameliorates cyclophosphamide-induced cardiotoxicity in Swiss albino mice: Targeting TLR4/NF-κB/NLRP3 signaling pathway	14
Inorganic arsenic exposure-induced premature senescence and senescence-associated secretory phenotype (SASP) in human hepatic stellate cells	14
Metformin-mediated modulation of gut microbiota–derived trimethylamine N-oxide (TMAO) in myocardial infarction: Insights from in vivo, metabolomics, and in silico studies	14
Effects of melatonin or physical exercise application in rats with hepatopulmonary syndrome	14
Acute ammonia stress affects the immune response, oxidative stress, ammonia transport and detoxication in the hepatopancreas of freshwater mollusk Solenaia oleivora	14
Formononetin ameliorates DSS-induced colitis by inhibiting the MAPK/PPAR-γ/NF-κB/ROS signaling pathways	14
A systematic review of mechanistic studies on the relationship between pesticide exposure and cancer induction	14
LCN2-positive alveolar type II cells promote silica-induced pulmonary fibrosis via STAT3-TGF-β1-Smad3-mediated signaling	14
TRPC6 promotes daunorubicin-induced mitochondrial fission and cell death in rat cardiomyocytes with the involvement of ERK1/2-DRP1 activation	14
Chlorogenic acid, rutin, and quercetin from Lysimachia christinae alleviate triptolide-induced multi-organ injury in vivo by modulating immunity and AKT/mTOR signal pathway to inhibit ferroptosis and	14
Fangchinoline alleviates the progression of osteoarthritis through the nuclear factor kappa B signaling pathway	14
Methylglyoxal produced by tumor cells through formaldehyde-enhanced Warburg effect potentiated polarization of tumor-associated macrophages	13
Cyanidin improves spatial memory and cognition in bisphenol A-induced rat model of Alzheimer's-like neuropathology by restoring canonical Wnt signaling	13
Centromere protein K enhances the activation of YAP1/TAZ signal cascade to drive the progression of clear cell renal cell carcinoma	13
Icariin promotes mouse Leydig cell testosterone synthesis via the Esr1/Src/Akt/Creb/Sf-1 pathway	13
The effects of sodium sulfite on Helicobacter pylori by establishing a hypoxic environment	13
Demethylzeylasteral inhibits osteosarcoma cell proliferation by regulating METTL17-mediated mitochondrial oxidative phosphorylation	13
The rapid transformation of triclosan in the liver reduces its effectiveness as inhibitor of hepatic energy metabolism	13
Therapeutic effects of berberine on hyperammonemia-associated neuroinflammation in thioacetamide-induced hepatic encephalopathy	13
Interactions between cadmium and 17β-estradiol at physiologically relevant levels evoke unsynchronized events in MCF-7 breast cancer cells: Impaired cell growth and activation of estrogen receptor α-r	13
Exposure of environmental trace elements in prostate cancer patients: A multiple metal analysis	13
Inhibition of tumor migration and invasion by fenofibrate via suppressing epithelial-mesenchymal transition in breast cancers	13
Investigating the anticancer properties of urolithin B in triple negative breast cancer: In vivo and in vitro insights	13
Circadian disruption and cisplatin chronotherapy for mammary carcinoma	13

Ameliorative effect of Schisandrol B against Diosbulbin B-induced hepatotoxicity via inhibiting CYP3A4-mediated bioactivation	13
Buspirone ameliorates premature ovarian insufficiency evoked by cyclophosphamide in female rats; attention to AMPK/Nrf2/HO-1, α-Klotho/NLRP3/Caspase-1, and Caspase-3-mediated apoptosis interplay	13
S100A11 mediates the protective effects of edaravone dexborneol on docetaxel-induced cognitive impairment in rats by inhibiting the MAPK signaling pathway	13
Chronic escalating-dose and acute binge cocaine treatments change the hippocampal cholinergic muscarinic system on drug presence and after withdrawal	13
Zebrafish larvae as a model for investigating dual effects of fluoride on bone development	13
Protective effect of rupatadine on testicular ischemia/reperfusion injury in rats: Modulation of IL-6/STAT3, Akt/ mTOR signaling pathways	13
Social isolation exacerbates acute ozone inhalation induced pulmonary and systemic health outcomes	12
Fenpropathrin provoked kidney damage via controlling the NLRP3/Caspase-1/GSDMD–mediated pyroptosis: The palliative role of curcumin-loaded chitosan nanoparticles	12
Effect of pharmacological modulation of the kynurenine pathway on pain-related behavior and opioid analgesia in a mouse model of neuropathic pain	12
Cepharanthine inhibits the proliferation of glioblastoma cells by blocking the autophagy–lysosomal pathway	12
Editorial Board	12
Naproxen sodium nanoparticles are less toxic and gastroprotective agents than the conventional NSAID drug naproxen sodium in Balb/c mice	12
Gallic acid ameliorates synovial inflammation and fibrosis by regulating the intestinal flora and its metabolites	12
Estimation of species- and sex-specific PFAS pharmacokinetics in mice, rats, and non-human primates using a Bayesian hierarchical methodology	12
Drug screening reveals the mechanism of toyocamycin-induced apoptosis in triple-negative breast cancer organoids	12
Corrigendum to “Differentiation of sow and mouse ovarian granulosa cells exposed to zearalenone in vitro using RNA-seq gene expression” [Toxicology and Applied Pharmacology, 350 (2018) 78–90]	12
Thymic lymphoma detection in RORγ knockout mice using 5-hydroxymethylcytosine profiling of circulating cell-free DNA	12
Ursolic acid alleviates steroid-induced avascular necrosis of the femoral head in mouse by inhibiting apoptosis and rescuing osteogenic differentiation	12
Role of ferroptosis in promoting cardiotoxicity induced by Imatinib Mesylate via down-regulating Nrf2 pathways in vitro and in vivo	12
Desloratadine mitigates hepatocellular carcinoma in rats: Possible contribution of TLR4/MYD88/NF-κB pathway	12
Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells	12
Assessing the neurotoxicity of airborne nano-scale particulate matter in human iPSC-derived neurons using a transcriptomics benchmark dose model	12
Editorial Board	12
Advances in research strategies and approaches for toxicity testing of environmental exposures	12
Changes in the gut microbiota of rats after exposure to the fungicide Mancozeb	11
Generation and distribution of cyanide in rats and humans following sodium cyanoborohydride exposure	11
Functional evaluation of CYP2C19 and CYP3A4 gene polymorphism on ibuprofen metabolism	11
Salvianolic acid B improves mitochondrial dysfunction of septic cardiomyopathy via enhancing ATF5-mediated mitochondrial unfolded protein response	11
Dysregulation of adipogenesis and disrupted lipid metabolism by the antidepressants citalopram and sertraline	11
Donepezil protects against cyclophosphamide-induced premature ovarian failure in mice: A focus on proinflammatory cytokines and NLRP3/TLR-4/NF-κB interplay	11
The anti-cancer drug candidate CBL0137 induced necroptosis via forming left-handed Z-DNA and its binding protein ZBP1 in liver cells	11
Unveiling the acute toxic pathology and transcriptomic signature of ocular exposure to phosgene oxime using an in vivo mouse model: A novel pilot study	11
The early inhibition of the COX-2 pathway in viperid phospholipase A2-induced skeletal muscle myotoxicity accelerates the tissue regeneration	11
Plasma microRNA-195, −34c, and − 1246 as novel biomarkers for the diagnosis of trastuzumab-resistant HER2-positive breast cancer patients	11
Isoflurane aggravates cognitive deficits in aged rats via lncRNA GABPB1-AS1/miR-361-3p-mediated NLRP3 inflammasome activation	11
Effect of pretreatment with a synbiotic on Perfluorooctanoic acid-induced liver damage after sub-acute oral exposure in C57BL/6J mice	11
Overexpression of peroxiredoxin 6 in bone marrow-derived mesenchymal stem cells amplifies their in vivo effect on bronchopulmonary dysplasia by increasing mesencephalic astrocyte-derived neurotrophic	11
Dibutylstannanediyl (2Z,2′Z)-bis(4-(benzylamino)-4-oxobut-2-enoate inhibits prostate cancer progression by activating p38 MAPK/PPARα/SMAD4 signaling	11
Impact of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) exposure on reproductive development in adolescent offspring	11
Celastrol alleviates high-fat diet-induced obesity via enhanced muscle glucose utilization and mitochondrial oxidative metabolism-mediated upregulation of pyruvate dehydrogenase complex	11
Novel microtubule inhibitor SQ overcomes multidrug resistance in MCF-7/ADR cells by inhibiting BCRP function and mediating apoptosis	11
Higher susceptibility of males to bleomycin-induced pulmonary inflammation is associated with sex-specific transcriptomic differences in myeloid cells	11
Benzyl isothiocyanate attenuates activation of the NLRP3 inflammasome in Kupffer cells and improves diet-induced steatohepatitis	11
C-Fos protein expression in the mouse brain: effects of nicotine aerosol	11
Targeted Per- and Polyfluoroalkyl substances (PFAS) assessments for high throughput screening: Analytical and testing considerations to inform a PFAS stock quality evaluation framework	11
Structural determinants of parabens in inhibiting human and rat gonadal 3β-hydroxysteroid dehydrogenase	11
PREX1 depletion ameliorates high-fat diet-induced non-alcoholic fatty liver disease in mice and mitigates palmitic acid-induced hepatocellular injury via suppressing the NF-κB signaling pathway	11
Analysis of accumulation of DNA double-strand breaks in mouse tissues by pulsed-field gel electrophoresis	11
Inflammation resolution in environmental pulmonary health and morbidity	11
Protein S-palmitoylation enhances profibrotic signaling in response to cadmium	11
Melatonin ameliorates PM2.5-induced airway inflammation and apoptosis by PERK/eIF2α/ATF4/CHOP in chronic obstructive pulmonary disease mice	11
Protective effects of microbial biosurfactants produced by Bacillus halotolerans and Candida parapsilosis on bleomycin-induced pulmonary fibrosis in mice: Impact of antioxidant, anti-inflammatory and	11
Association of urinary arsenic, polycyclic aromatic hydrocarbons, and metals with cancers among the female population in the US	10
Paricalcitol, an active vitamin D analog, mitigates dexamethasone-induced hepatic injury: Role of autophagy, pyroptosis, and PERK/Nrf2/HO-1 signaling pathway	10
Integrative description of changes occurring on zebrafish embryos exposed to water-soluble crude oil components and its mixture with a chemical surfactant	10
Nimbolide attenuated the inflammation in the liver of autoimmune hepatitis's mice through regulation of HDAC3	10
Epicatechin exerts dual action to shield sickling and hydroxyurea-induced myelosuppression: Implication in sickle cell anemia management	10
Delineation of the molecular mechanisms underlying Colistin-mediated toxicity using metabolomic and transcriptomic analyses	10
Editorial Board	10
Epigallocatechin gallate ameliorates retinal pigment epithelial cell damage via the CYFIP2 /AKT pathway	10
New insight into methamphetamine-associated heart failure revealed by transcriptomic analyses: Circadian rhythm disorder	10
Editorial Board	10
Aucubin provides protection against cerebral ischaemia-reperfusion injury by suppressing neuronal apoptosis, oxidative stress, and inflammation through the modulation of the AKT-GSK-3β-Nrf2 signal cas	10
The role of NUPR1 in response to stress and cancer development	10
SNAI1-expressing fibroblasts and derived-extracellular matrix as mediators of drug resistance in colorectal cancer patients	10
Neuroprotective effects of ibudilast against tacrolimus induced neurotoxicity	10
Lupeol, an androgen receptor inhibitor, enhances the chemosensitivity of prostate cancer stem cells to antiandrogen enzalutamide-based therapy	10
Corrigendum to “FOXO3a reactivation mediates the synergistic cytotoxic effects of rapamycin and cisplatin in oral squamous cell carcinoma cells” [Toxicology and Applied Pharmacology 251 (2011) 8–15]	10
The ABCB1 and ABCG2 efflux transporters limit brain disposition of the SYK inhibitors entospletinib and lanraplenib	10
Corrigendum to “PKC-δ-dependent mitochondrial ROS attenuation is involved as 9-OAHSA combats lipoapotosis in rat hepatocytes induced by palmitic acid and in Syrian hamsters induced by high-fat high-ch	10
Editorial Board	10
Integrated network toxicology, transcriptomics and gut microbiomics reveals hepatotoxicity mechanism induced by benzo[a]pyrene exposure in mice	10
Editorial Board	10
Pirfenidone ameliorates ANIT-induced cholestatic liver injury via modulation of FXR, NF-кB/TNF-α, and Wnt/GSK-3β/β-catenin signaling pathways	10
Arsenic trioxide inhibits the functions of lung fibroblasts derived from patients with idiopathic pulmonary fibrosis	10
Editorial Board	10
Dihydromyricetin attenuates cisplatin-induced acute kidney injury by reducing oxidative stress, inflammation and ferroptosis	10
Hainanolide inhibits the progression of colon cancer via inducing the cell cycle arrest, cell apoptosis and activation of the MAPK signaling pathway	10
Identification of novel and potential PPARγ stimulators as repurposed drugs for MCAO associated brain degeneration	10
Exploring retinoic acid-induced skin irritation: Pathological and mechanistic insights from an ex vivo porcine skin model	10
Proline betaine facilitates angiogenesis in bronchopulmonary dysplasia	10
Editorial Board	10
ALKBH5 regulates paclitaxel resistance in NSCLC via inhibiting CEMIP-mediated EMT	10
Elucidating the relationship between metabolites and breast cancer: A Mendelian randomization study	10
Editorial Board	10
In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen recept	10
AhR signaling modulates Ferroptosis by regulating SLC7A11 expression	10
Development of quercetin-loaded PVCL–PVA–PEG micelles and application in inhibiting tumor angiogenesis through the PI3K/Akt/VEGF pathway	10
Unveiling the therapeutic potential and leukemia risk of PD-166866 in sepsis via an integrated computational-experimental strategy	10
Weight of evidence evaluation of the metabolism disrupting effects of triphenyl phosphate using an expert knowledge elicitation approach	10
3,4-Dimethoxycinnamic acid from coffee silverskin biowaste ameliorates bleomycin-induced pulmonary fibrosis via modulating caveolin-1-dependent activation of NF-κB, TGF-β1/Smad3, and ERK1/2 signaling	9
Inhibition of angiotensin pathway via valsartan reduces tumor growth in models of colorectal cancer	9
PARP inhibitor BMN-673 induced apoptosis by trapping PARP-1 and inhibiting base excision repair via modulation of pol-β in chromatin of breast cancer cells	9
The protective effect of safranal against intestinal tissue damage in Drosophila	9
Isonardosinone attenuates osteoclastogenesis and OVX-induced bone loss via the MAPK/NF-κB pathway	9