Toxicology and Applied Pharmacology

Article	Citations
In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen recept	72
Edible plant-derived exosomal microRNAs: Exploiting a cross-kingdom regulatory mechanism for targeting SARS-CoV-2	70
Arsenic-induced changes in miRNA expression in cancer and other diseases	61
Melatonin alleviates doxorubicin-induced mitochondrial oxidative damage and ferroptosis in cardiomyocytes by regulating YAP expression	55
Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis	53
Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuro	51
Octreotide and melatonin alleviate inflammasome-induced pyroptosis through inhibition of TLR4-NF-κB-NLRP3 pathway in hepatic ischemia/reperfusion injury	50
Delivery of oxaliplatin to colorectal cancer cells by folate-targeted UiO-66-NH2	45
Effects of an environmentally relevant PFAS mixture on dopamine and steroid hormone levels in exposed mice	40
Vildagliptin, a DPP-4 inhibitor, attenuates carbon tetrachloride-induced liver fibrosis by targeting ERK1/2, p38α, and NF-κB signaling	40
4-methylpyrazole protects against acetaminophen-induced acute kidney injury	39
Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis	38
Induction of apoptosis in breast cancer cells by naphthylisoquinoline alkaloids	38
Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis	38
TGF-β1-induced EMT activation via both Smad-dependent and MAPK signaling pathways in Cu-induced pulmonary fibrosis	37
Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPARα mice fed an American diet	35
Balance between the toxicity and anticancer activity of arsenic trioxide in treatment of acute promyelocytic leukemia	35
Perfluorooctanesulfonic acid (PFOS) administration shifts the hepatic proteome and augments dietary outcomes related to hepatic steatosis in mice	35
Menthol in electronic cigarettes: A contributor to respiratory disease?	34
Arsenic-induced lung inflammation and fibrosis in a rat model: Contribution of the HMGB1/RAGE, PI3K/AKT, and TGF-β1/SMAD pathways	34
(−)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD	33
Generating adverse outcome pathway (AOP) of inorganic arsenic-induced adult male reproductive impairment via integration of phenotypic analysis in comparative toxicogenomics database (CTD) and AOP wik	33
Arsenic-protein interactions as a mechanism of arsenic toxicity	32
Sulforaphane inhibits blue light–induced inflammation and apoptosis by upregulating the SIRT1/PGC-1α/Nrf2 pathway and autophagy in retinal pigment epithelial cells	30
Cadmium induced inflammation and apoptosis of porcine epididymis via activating RAF1/MEK/ERK and NF-κB pathways	30

A transcriptomic overview of lung and liver changes one day after pulmonary exposure to graphene and graphene oxide	30
Health disparities: Intracellular consequences of social determinants of health	29
Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways	29
Low dose spironolactone-mediated androgen-adiponectin modulation alleviates endocrine-metabolic disturbances in letrozole-induced PCOS	28
Effects of environmental and occupational lead toxicity and its association with iron metabolism	28
Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes	27
Cardiac toxicity from bisphenol A exposure in human-induced pluripotent stem cell-derived cardiomyocytes	27
Molecular and clinical insights of matrix metalloproteinases into cancer spread and potential therapeutic interventions	27
Cisplatin induces autophagy-associated apoptosis in human oral squamous cell carcinoma (OSCC) mediated in part through reactive oxygen species	27
Natural products in the reprogramming of cancer epigenetics	26
Targeting autophagy by natural product Ursolic acid for prevention and treatment of osteoporosis	26
Lactobacillus rhamnosus GG combined with inosine ameliorates alcohol-induced liver injury through regulation of intestinal barrier and Treg/Th1 cells	26
Network pharmacology and molecular docking analysis on molecular targets: Mechanisms of baicalin and baicalein against hyperuricemic nephropathy	26
Comparative analysis of the physicochemical, toxicokinetic, and toxicological properties of ether-PFAS	25
A systematic review of clinical and laboratory findings of lead poisoning: lessons from case reports	25
Toxicity analysis of endocrine disrupting pesticides on non-target organisms: A critical analysis on toxicity mechanisms	25
Amentoflavone prevents ox-LDL-induced lipid accumulation by suppressing the PPARγ/CD36 signal pathway	25
Nano selenium protects against deltamethrin-induced reproductive toxicity in male rats	25
The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice	24
Targeting CD166+ lung cancer stem cells: Molecular study using murine dendritic cell vaccine	24
Zebrafish early life stages as alternative model to study ‘designer drugs’: Concordance with mammals in response to opioids	24
Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment	23
Astaxanthin attenuates alcoholic cardiomyopathy via inhibition of endoplasmic reticulum stress-mediated cardiac apoptosis	23
Oxytetracycline induces anxiety-like behavior in adult zebrafish	23
Pulmonary toxicants and fibrosis: innate and adaptive immune mechanisms	23
Polyphyllin I reverses the resistance of osimertinib in non-small cell lung cancer cell through regulation of PI3K/Akt signaling	23
Curcumin ameliorates hypertension via gut-brain communication in spontaneously hypertensive rat	23
Improved bioavailability and anticancer efficacy of Hesperetin on breast cancer via a self-assembled rebaudioside A nanomicelles system	22
MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf2	22
Ononin alleviates endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity by activating SIRT3	22
SPP1 derived from silica-exposed macrophage exosomes triggers fibroblast transdifferentiation	22
Heart slice culture system reliably demonstrates clinical drug-related cardiotoxicity	22
Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway	21
Co-exposure to PCB126 and PFOS increases biomarkers associated with cardiovascular disease risk and liver injury in mice	21
Diosgenin alleviates hypercholesterolemia via SRB1/CES-1/CYP7A1/FXR pathway in high-fat diet-fed rats	21
Food emulsifier polysorbate 80 promotes the intestinal absorption of mono-2-ethylhexyl phthalate by disturbing intestinal barrier	21
Daphnetin ameliorates glucocorticoid-induced osteoporosis via activation of Wnt/GSK-3β/β-catenin signaling	21
Remdesivir; molecular and functional measures of mitochondrial safety	21
Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil	20
Application of Cell Painting for chemical hazard evaluation in support of screening-level chemical assessments	20
Methamphetamine induces intestinal injury by altering gut microbiota and promoting inflammation in mice	20
An inclusive outlook on the fate and persistence of pesticides in the environment and integrated eco-technologies for their degradation	20
Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/β-catenin, AMPK/mTOR signaling pathways	20
Paris saponin II-induced paraptosis-associated cell death increased the sensitivity of cisplatin	20
Hydrogen sulfide attenuates postoperative cognitive dysfunction through promoting the pathway of Warburg effect-synaptic plasticity in hippocampus	20
The protective mechanism of resveratrol against hepatic injury induced by iron overload in mice	20
Chloroquine may induce endothelial injury through lysosomal dysfunction and oxidative stress	20
Prepubertal exposure to arsenic alters male reproductive parameters in pubertal and adult rats	20
Thymol activates TRPM8-mediated Ca2+ influx for its antipruritic effects and alleviates inflammatory response in Imiquimod-induced mice	20
Role of the PI3K/Akt pathway in cadmium induced malignant transformation of normal prostate epithelial cells	19

The interrupted cross-talk of inflammatory and oxidative stress trajectories signifies the effect of artesunate against hepatic ischemia/reperfusion-induced inflammasomopathy	19
Molecular docking analyses of Escin as regards cyclophosphamide-induced cardiotoxicity: In vivo and in Silico studies	19
Inorganic arsenic and its methylated metabolites as endocrine disruptors in the placenta: Mechanisms underpinning glucocorticoid receptor (GR) pathway perturbations	19
Exposure to alternative bisphenols BPS and BPF through breast milk: Noxious heritage effect during nursing associated with idiopathic infertility	19
Linagliptin ameliorates acetic acid-induced colitis via modulating AMPK/SIRT1/PGC-1α and JAK2/STAT3 signaling pathway in rats	19
A network pharmacology approach to investigate the anticancer mechanism of cinobufagin against hepatocellular carcinoma via downregulation of EGFR-CDK2 signaling	19
Pharmacological postconditioning with sappanone A ameliorates myocardial ischemia reperfusion injury and mitochondrial dysfunction via AMPK-mediated mitochondrial quality control	19
NURA: A curated dataset of nuclear receptor modulators	19
HepG2 (C3A) spheroids show higher sensitivity compared to HepaRG spheroids for drug-induced liver injury (DILI)	19
Arsenic induced redox imbalance triggers the unfolded protein response in the liver of zebrafish	19
Schisandrin B induces HepG2 cells pyroptosis by activating NK cells mediated anti-tumor immunity	19
Salidroside attenuates myocardial ischemia/reperfusion injury via AMPK-induced suppression of endoplasmic reticulum stress and mitochondrial fission	18
Environmental exposure to volatile organic compounds is associated with endothelial injury	18
Oxidative stress, genotoxic effects, and other damages caused by chronic exposure to silver nanoparticles (Ag NPs) and zinc oxide nanoparticles (ZnO NPs), and their mixtures in zebrafish (Danio rerio)	18
Ligustilide inhibits the proliferation of non-small cell lung cancer via glycolytic metabolism	18
Ethyl maltol enhances copper mediated cytotoxicity in lung epithelial cells	18
U0126 pretreatment inhibits cisplatin-induced apoptosis and autophagy in HEI-OC1 cells and cochlear hair cells	18
Breast cancer cells-derived Von Willebrand Factor promotes VEGF-A-related angiogenesis through PI3K/Akt-miR-205-5p signaling pathway	18
Curcumin alleviates arsenic-induced injury in duck skeletal muscle via regulating the PINK1/Parkin pathway and protecting mitochondrial function	18
Targeted Per- and Polyfluoroalkyl substances (PFAS) assessments for high throughput screening: Analytical and testing considerations to inform a PFAS stock quality evaluation framework	17
T helper 2-driven immune dysfunction in chronic arsenic-exposed individuals and its link to the features of allergic asthma	17
Ozone-induced changes in oxidative stress parameters in brain regions of adult, middle-age, and senescent Brown Norway rats	17
Isorhynchophylline ameliorates paraquat-induced acute kidney injury by attenuating oxidative stress and mitochondrial damage via regulating toll-interacting expression	17
Gut microbiome-host interactions in driving environmental pollutant trichloroethene-mediated autoimmunity	17
Cetylpyridinium chloride (CPC) reduces zebrafish mortality from influenza infection: Super-resolution microscopy reveals CPC interference with multiple protein interactions with phosphatidylinositol 4	17
Developmental arsenic exposure induces dysbiosis of gut microbiota and disruption of plasma metabolites in mice	17
Apigenin alleviates cancer drug Sorafenib induced multiple toxic effects in Swiss albino mice via anti-oxidative stress	17
Safety assessment of drug combinations used in COVID-19 treatment: in silico toxicogenomic data-mining approach	17
Role of ferroptosis in promoting cardiotoxicity induced by Imatinib Mesylate via down-regulating Nrf2 pathways in vitro and in vivo	17
Resveratrol and its nanocrystals: A promising approach for cancer therapy?	17
C-myc promotes miR-92a-2-5p transcription in rat ovarian granulosa cells after cadmium exposure	16
Dihydromyricetin attenuates cisplatin-induced acute kidney injury by reducing oxidative stress, inflammation and ferroptosis	16
CoQ10 protects against acetaminophen-induced liver injury by enhancing mitophagy	16
S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs	16
Inflammatory effects of hexavalent chromium in the lung: A comprehensive review	16
Astrocytic Kir4.1 regulates NMDAR/calpain signaling axis in lipopolysaccharide-induced depression-like behaviors in mice	16
The role of NUPR1 in response to stress and cancer development	16
Synergistic action of organophosphates and COVID-19 on inflammation, oxidative stress, and renin-angiotensin system can amplify the risk of cardiovascular maladies	16
Mitoquinone protects against acetaminophen-induced liver injury in an FSP1-dependent and GPX4-independent manner	16
Natural bioactive compounds-doxorubicin combinations targeting topoisomerase II-alpha: Anticancer efficacy and safety	16
Involvement of endoplasmic reticulum stress-activated PERK-eIF2α-ATF4 signaling pathway in T-2 toxin-induced apoptosis of porcine renal epithelial cells	16
Development of quercetin-loaded PVCL–PVA–PEG micelles and application in inhibiting tumor angiogenesis through the PI3K/Akt/VEGF pathway	16
α-Phellandrene exhibits antinociceptive and tumor-reducing effects in a mouse model of oncologic pain	16
Apple polyphenol phloretin complexed with ruthenium is capable of reprogramming the breast cancer microenvironment through modulation of PI3K/Akt/mTOR/VEGF pathways	16
A systematic review of mechanistic studies on the relationship between pesticide exposure and cancer induction	16
Chlorogenic acid, rutin, and quercetin from Lysimachia christinae alleviate triptolide-induced multi-organ injury in vivo by modulating immunity and AKT/mTOR signal pathway to inhibit ferroptosis and	15
Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress	15
Mechanism of hepatobiliary toxicity of the LPA1 antagonist BMS-986020 developed to treat idiopathic pulmonary fibrosis: Contrasts with BMS-986234 and BMS-986278	15
MST2 silencing induces apoptosis and inhibits tumor growth for estrogen receptor alpha-positive MCF-7 breast cancer	15
Mitoglitazone ameliorates renal ischemia/reperfusion injury by inhibiting ferroptosis via targeting mitoNEET	15
Resveratrol ameliorates lipopolysaccharide-induced anxiety-like behavior by attenuating YAP-mediated neuro-inflammation and promoting hippocampal autophagy in mice	15
Forsythoside A inhibits adhesion and migration of monocytes to type II alveolar epithelial cells in lipopolysaccharide-induced acute lung injury through upregulating miR-124	15
Titanium dioxide nanoparticles induced reactive oxygen species (ROS) related changes of metabolomics signatures in human normal bronchial epithelial (BEAS-2B) cells	15
Crosstalk between the aryl hydrocarbon receptor (AhR) and the peroxisome proliferator-activated receptor gamma (PPARγ) as a key factor in the metabolism of silver nanoparticles in neuroblastoma (SH-SY	15
Hydrogen sulfide attenuates induction and prevents progress of the 6-hydroxydopamine-induced Parkinsonism in rat through activation of ATP-sensitive potassium channels and suppression of ER stress	15
Crocin induces ROS-mediated papillary thyroid cancer cell apoptosis by modulating the miR-34a-5p/PTPN4 axis in vitro	15
Andrographolide inhibits IL-1β release in bone marrow-derived macrophages and monocyte infiltration in mouse knee joints induced by monosodium urate	15
Crosstalk between gut microbiota and lung inflammation in murine toxicity models of respiratory exposure or co-exposure to carbon nanotube particles and cigarette smoke extract	15
Final results from a 90-day quantitative inhalation toxicology study evaluating the dose-response and fate in the lung and pleura of chrysotile-containing brake dust compared to TiO2, chrysotile, croc	15
Down-regulation of lncRNA MEG3 promotes chronic low dose cadmium exposure-induced cell transformation and cancer stem cell-like property	15
Species-specific differences in the inhibition of 11β-hydroxysteroid dehydrogenase 2 by itraconazole and posaconazole	15
Enzyme-sensitive nanoparticles, smart TAT and cetuximab conjugated immunoliposomes to overcome multidrug resistance in breast cancer cells	14
Metformin leads to accumulation of reactive oxygen species by inhibiting the NFE2L1 expression in human hepatocellular carcinoma cells	14
Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio	14
The Aryl hydrocarbon receptor mediates reproductive toxicity of polychlorinated biphenyl congener 126 in rats	14
Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma by blocking Wnt/β-catenin/STAT3 axis	14
Biological effects of inhaled hydraulic fracturing sand dust. III. Cytotoxicity and pro-inflammatory responses in cultured murine macrophage cells	14
Epidermal Growth Factor-labeled liposomes as a way to target the toxicity of silver nanoparticles into EGFR-overexpressing cancer cells in vitro	14
Whole life exposure to low dose cadmium alters diet-induced NAFLD	14
Effect of dexamethasone treatment at variable therapeutic windows in reversing nitrogen mustard-induced corneal injuries in rabbit ocular in vivo model	14
Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3	14
MiR-3663-3p participates in the anti-hepatocellular carcinoma proliferation activity of baicalein by targeting SH3GL1 and negatively regulating EGFR/ERK/NF-κB signaling	14
Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data	14
Time-to-treatment window and cross-sex potential of β2-adrenergic receptor-induced mitochondrial biogenesis-mediated recovery after spinal cord injury	14
NLRP3 protects mice from radiation-induced colon and skin damage via attenuating cGAS-STING signaling	14
Anemoside A3 activates TLR4-dependent M1-phenotype macrophage polarization to represses breast tumor growth and angiogenesis	14
Intranasal curcumin and dexamethasone combination ameliorates inflammasome (NLRP3) activation in lipopolysachharide exposed asthma exacerbations	14
Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition	13
Icariin promotes mouse Leydig cell testosterone synthesis via the Esr1/Src/Akt/Creb/Sf-1 pathway	13
Picroside II alleviates liver injury induced by alpha-naphthylisothiocyanate through AMPK-FXR pathway	13

Biological effects of inhaled hydraulic fracturing sand dust. VI. Cardiovascular effects	13
Differential impact of doxorubicin dose on cell death and autophagy pathways during acute cardiotoxicity	13
Arsenic induced epigenetic changes and relevance to treatment of acute promyelocytic leukemia and beyond	13
Synthetic cannabinoids enhanced ethanol-induced motor impairments through reduction of central glutamate neurotransmission	13
Effects of classic antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish	13
Nanotechnology-based pesticides: Environmental fate and ecotoxicity	13
Sex-specific behavioral effects of acute exposure to the neonicotinoid clothianidin in mice	13
Liver-specific Nrf2 deficiency accelerates ethanol-induced lethality and hepatic injury in vivo	13
Metabolic profile of methylazoxymethanol model of schizophrenia in rats and effects of three antipsychotics in long-acting formulation	13
Developmental exposure of bisphenol A induces spatial memory deficits by weakening the excitatory neural circuits of CA3-CA1 and EC-CA1 in mice	12
Gestational arsenic exposure and paternal intergenerational epigenetic inheritance	12
Paraquat pharmacokinetics in primates and extrapolation to humans	12
Arsenic metabolism differs between child and adult patients during acute arsenic poisoning	12
Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat	12
Hydroxysafflor yellow A protects against colitis in mice by suppressing pyroptosis via inhibiting HK1/NLRP3/GSDMD and modulating gut microbiota	12
Transgenerational effects of developmental exposure to chlorpyrifos-oxon in zebrafish (DANIO RERIO)	12
Chronic arsenic exposure suppresses ATM pathway activation in human keratinocytes	12
The ubiquitination and acetylation of histones are associated with male reproductive disorders induced by chronic exposure to arsenite	12
Induction of ZIP8, a ZIP transporter, via NF-κB signaling by the activation of IκBα and JNK signaling in cultured vascular endothelial cells exposed to cadmium	12
Mogrol suppresses lung cancer cell growth by activating AMPK-dependent autophagic death and inducing p53-dependent cell cycle arrest and apoptosis	12
Curcumin nanocrystals attenuate cyclophosphamide-induced testicular toxicity in mice	12
Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or KATP channels inhibitors	12
Chronic cannabidiol treatment reduces the carbachol-induced coronary constriction and left ventricular cardiomyocyte width of the isolated hypertensive rat heart	12
Metformin relieves H/R-induced cardiomyocyte injury through miR-19a/ACSL axis - possible therapeutic target for myocardial I/R injury	12
Biological effects of inhaled hydraulic fracturing sand dust. VIII. Immunotoxicity	12
Upcycling the anthracyclines: New mechanisms of action, toxicology, and pharmacology	12
Arsenic exposure in drinking water reduces Lgr5 and secretory cell marker gene expression in mouse intestines	12
Anacardic 6-pentadecyl salicylic acid induces apoptosis in breast cancer tumor cells, immunostimulation in the host and decreases blood toxic effects of taxol in an animal model	12
Perinatal exposure to a glyphosate pesticide formulation induces offspring liver damage	12
Predicting changes in renal metabolism after compound exposure with a genome-scale metabolic model	12
ATP and ADP enhance DNA damage repair in γ-irradiated BEAS-2B human bronchial epithelial cells through activation of P2X7 and P2Y12 receptors	12
Long non-coding RNA CYTOR modulates cancer progression through miR-136-5p/MAT2B axis in renal cell carcinoma	12
Combining phenotypic profiling and targeted RNA-Seq reveals linkages between transcriptional perturbations and chemical effects on cell morphology: Retinoic acid as an example	12
Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-κB activation	12
Bisphenol analogs AF and S: Effects on cell status and production of angiogenesis-related factors by COV434 human granulosa cell line	12
Arsenic as an immunotoxicant	11
SNAI1-expressing fibroblasts and derived-extracellular matrix as mediators of drug resistance in colorectal cancer patients	11
Malformations and mortality in zebrafish early stages associated with elevated caspase activity after 24 h exposure to MS-222	11
NRF2/PGC-1α-mediated mitochondrial biogenesis contributes to T-2 toxin-induced toxicity in human neuroblastoma SH-SY5Y cells	11
The contribution of the neuroendocrine system to adaption after repeated daily ozone exposure in rats	11
Long-isoform NRF1 protects against arsenic cytotoxicity in mouse bone marrow-derived mesenchymal stem cells by suppressing mitochondrial ROS and facilitating arsenic efflux	11
Triptolide impairs glycolysis by suppressing GATA4/Sp1/PFKP signaling axis in mouse Sertoli cells	11
Biological effects of inhaled hydraulic fracturing sand dust. IV. Pulmonary effects	11
Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy	11
Inflammation resolution in environmental pulmonary health and morbidity	11
Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation	11
Oleanolic acid-loaded nanoparticles attenuate activation of hepatic stellate cells via suppressing TGF-β1 and oxidative stress in PM2.5-exposed hepatocytes	11
Catalpol induces apoptosis in breast cancer in vitro and in vivo: Involvement of mitochondria apoptosis pathway and post-translational modifications	11
Comparison of IQOS (heated tobacco) and cigarette smoking on cardiac functions by two-dimensional speckle tracking echocardiography	11
Down-regulation of Survivin and Bcl-2 concomitant with the activation of caspase-3 as a mechanism of apoptotic death in KG1a and K562 cells upon exposure to a derivative from ciprofloxacin family	11
Kynurenic acid ameliorates lipopolysaccharide-induced endometritis by regulating the GRP35/NF-κB signaling pathway	11
Identification of four methylation-driven genes as candidate biomarkers for monitoring single-walled carbon nanotube-induced malignant transformation of the lung	11
Assessing the impacts on fetal dosimetry of the modelling of the placental transfers of xenobiotics in a pregnancy physiologically based pharmacokinetic model	11
Female-specific activation of pregnane X receptor mediates sex difference in fetal hepatotoxicity by prenatal monocrotaline exposure	11
Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation	11
Fraxinellone alleviates kidney fibrosis by inhibiting CUG-binding protein 1-mediated fibroblast activation	11
PBK modelling of topical application and characterisation of the uncertainty of Cmax estimate: A case study approach	11
Proarrhythmic effects induced by benzethonium chloride and domiphen bromide in vitro and in vivo	10
Inhibition of notch enhances the anti-atherosclerotic effects of LXR agonists while reducing fatty liver development in ApoE-deficient mice	10
A natural product, voacamine, sensitizes paclitaxel-resistant human ovarian cancer cells	10
Safranal inhibits NLRP3 inflammasome activation by preventing ASC oligomerization	10
Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX	10
Restraint of chaperonin containing T-complex protein-1 subunit 3 has antitumor roles in non-small cell lung cancer via affection of YAP1	10
In utero exposure to dipentyl phthalate disrupts fetal and adult Leydig cell development	10
EGCG protects against myocardial I/RI by regulating lncRNA Gm4419-mediated epigenetic silencing of the DUSP5/ERK1/2 axis	10
Asenapine and iloperidone decrease the expression of major cytochrome P450 enzymes CYP1A2 and CYP3A4 in human hepatocytes. A significance for drug-drug interactions during combined therapy	10
Deacetylated nimbin analog N2 fortifies alloxan-induced pancreatic β-cell damage in insulin-resistant zebrafish larvae by upregulating phosphoenolpyruvate carboxykinase (PEPCK) and insulin levels	10
Disruption of pulmonary resolution mediators contribute to exacerbated silver nanoparticle-induced acute inflammation in a metabolic syndrome mouse model	10
Pentoxifylline and thiamine ameliorate rhabdomyolysis-induced acute kidney injury in rats via suppressing TLR4/NF-κB and NLRP-3/caspase-1/gasdermin mediated-pyroptosis	10
NAM protects against cisplatin-induced acute kidney injury by suppressing the PARP1/p53 pathway	10
Genomic methylation variations predict the susceptibility of six chemotherapy related adverse effects and cancer development for Chinese colorectal cancer patients	10
Developmental programming: Impact of prenatal bisphenol-A exposure on liver and muscle transcriptome of female sheep	10
CYP3A deficiency alters bile acid homeostasis and leads to changes in hepatic susceptibility in rats	10
S-(+)-Pentedrone and R-(+)-methylone as the most oxidative and cytotoxic enantiomers to dopaminergic SH-SY5Y cells: Role of MRP1 and P-gp in cathinones enantioselectivity	10
The insecticide deltamethrin enhances sodium channel slow inactivation of human Nav1.9, Nav1.8 and Nav1.7	10
N-Acetyl-Seryl-Asparyl-Lysyl-Proline regulates lung renin angiotensin system to inhibit epithelial–mesenchymal transition in silicotic mice	10
Stimulation of adenosine A1 receptor prevents oxidative injury in H9c2 cardiomyoblasts: Role of Gβγ-mediated Akt and ERK1/2 signaling	10
Ellagic acid ameliorates hexavalent chromium-induced renal toxicity by attenuating oxidative stress, suppressing TNF-α and protecting mitochondria	10
Inhibition of angiotensin pathway via valsartan reduces tumor growth in models of colorectal cancer	10
The therapeutic effect of hesperetin on doxorubicin-induced testicular toxicity: Potential roles of the mechanistic target of rapamycin kinase (mTOR) and dynamin-related protein 1 (DRP1)	10
Pegbelfermin, a PEGylated FGF21 analogue, has pharmacology without bone toxicity after 1-year dosing in skeletally-mature monkeys	10
Agomelatine protects against obesity-induced renal injury by inhibiting endoplasmic reticulum stress/apoptosis pathway in rats	10
Nabumetone induced photogenotoxicity mechanism mediated by ROS generation under environmental UV radiation in human keratinocytes (HaCaT) cell line	10
Resveratrol protects against doxorubicin-induced cardiotoxicity by attenuating ferroptosis through modulating the MAPK signaling pathway	10
Alisertib shows negligible potential for perpetrating pharmacokinetic drug-drug interactions on ABCB1, ABCG2 and cytochromes P450, but acts as dual-activity resistance modulator through the inhibition	10
Evaluation of human relevance of Nicofluprole-induced rat thyroid disruption	9
Chemical mitochondrial uncouplers share common inhibitory effect on NLRP3 inflammasome activation through inhibiting NFκB nuclear translocation	9
Immunosuppression, oxidative stress, and apoptosis in pig kidney caused by ammonia: Application of transcriptome analysis in risk assessment of ammonia exposure	9
Dabrafenib inhibits ABCG2 and cytochrome P450 isoenzymes; potential implications for combination anticancer therapy	9
In utero di-(2-ethylhexyl) phthalate-induced testicular dysgenesis syndrome in male newborn rats is rescued by taxifolin through reducing oxidative stress	9
CREB1 protects against the renal injury in a rat model of kidney stone disease and calcium oxalate monohydrate crystals-induced injury in NRK-52E cells	9
KLF15 negatively regulates cardiac fibrosis by which SDF-1β attenuates cardiac fibrosis in type 2 diabetic mice	9
Evaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish	9
Fatty acid nitroalkenes inhibit the inflammatory response to bleomycin-mediated lung injury	9
Roflupram attenuates α-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant α-synuclein	9