OOIR: Observatory of International Research

Papers

(The TQCC of Steroids is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Editorial Board	45
Cortisol resistance in the degu (Octodon degus)	40
Isolation, structural elucidation of new phytoecdysteroids from Ajuga decumbens Thunb	34
Retraction notice to “Thyroid hormone is a MAPK-dependent growth factor for thyroid cancer cells and is anti-apoptotic” [Steroids 72(2) 2007 180–187]	33
Synthesis of methotrexate-betulonic acid hybrids and evaluation of their effect on artificial and Caco-2 cell membranes	31
Membrane progesterone receptors on the cell membrane: A review highlighting potential export motifs in mPRα regulating its trafficking to the cell surface	30
Nandrolone decanoate induced kidney injury through miRNA-146a targeting IRAK1 and TRAF6 via activation of the NF-κB pathway: The effect of moderate exercise	29
Kaempferol ameliorates PCOS by alleviating metabolic and endocrine abnormalities as well as oxidative stress	29
Mitochondrial dysfunction and cardiac ischemia/reperfusion injury are attenuated by nandrolone: Role of JAK-STAT3 pathway	28
Roles of equol and the PI3K/Akt signaling pathway in the cardioprotective effects of enteral daidzein against ischemia–reperfusion injury in isolated rat hearts	26
Ursane hybrids with 5-amino-1,2,3,4-thiatriazole, 1-tetrazole-5-thione, and 1-tetrazole-5-amines and study of their inhibition of main SARS-CoV-2 protease	23
Mineralocorticoid receptor antagonism of vamorolone: Evidence from LIONHEART and VISION-DMD clinical trials	21
Acquired 11β-Hydroxylase deficiency in etomidate and (Iso)propoxate abusers: A nascent endocrine condition	20
Endoplasmic reticulum stress and steroidogenic dysfunction in Leydig cells: Molecular mechanisms of UPR-mediated testosterone regulation	20
Effects of estradiol, progesterone or cAMP on expression of PGRMC1 and progesterone receptor in a xenograft model of human endometrium and in endometrial cell culture	20
Ligand-based analysis of the antifungal potential of phytosterols and triterpenes isolated from Cryptostegia grandiflora against Candida auris FKBP12	19
Adolescent chronic unpredictable mild stress impairs adult adrenal steroidogenesis in mice via glucocorticoid-mediated downregulation of SHH promoter H3K4me3 and hedgehog signaling	19
Unleashing the pharmacological potential of taste receptors in reproductive processes beyond their gustatory role	18
Synthesis, antifungal evaluation, and molecular docking studies of steroidal thiazolopyrimidines	17
Drugs possessing aryloxypropanamine pharmacophore, duloxetine, dapoxetine and propranolol, increase allopregnanolone in rat brain: Possible involvement of allopregnanolone in their central nervous sys	17
Androgenic steroids in Over-the-Counter dietary Supplements: Analysis for association with adverse health effects	17
An improved synthesis of azedarachol	17
Epoxide of diosgenin acetate synthesis: DoE for diastereoselective yield optimization, antimicroibial, antioxidant and antiproliferative effects	16
Biotransformation of hydrocortisone succinate with whole cell cultures of Monascus purpureus and Cunninghamella echinulata	16
Antitumor potential of novel 5α,6β-dibromo steroidal D-homo lactone	16

Ascorbic acid Mitigates behavioural disturbances associated with letrozole-induced PCOS via switching-off JAK2/STAT5 and JAK2/ERK1/2 pathways in rat hippocampus	16
17beta-estradiol alleviates contusion-induced skeletal muscle injury by decreasing oxidative stress via SIRT1/PGC-1α/Nrf2 pathway	15
The location of estrogen receptor variant ER-α36 is associated with the invasion of glioblastoma	15
Synthesis and antitumor activity of some cholesterol-based selenocyanate compounds	15
Exploring the urate lowering properties of Erigeron annuus Lin. and phytosterol contributions: In vitro assays and in silico approaches	15
Target-specific high-throughput screening of anti-inflammatory phytosteroids for autoimmune diseases: A molecular docking-dynamics simulation approach	15
Theoretical study of the pyridyl-cholestane formation pathway using DFT: A stepwise mechanistic approach	14
Retraction notice to “Design and synthesis of two new steroid derivatives with biological activity on heart failure via the M2-muscarinic receptor activation” [Steroids 158 (2020) 108620]	14
Systemic corticosteroid use and cardiovascular risk in patients hospitalized for pneumonia	14
Synthesis, anti-leukemia activity, and molecular docking of novel 3,16-androstenedione derivatives	14
Editorial Board	13
The effect of transdermal 17β-estradiol combined with norethisterone acetate treatment on the lipid profile in postmenopausal women: A meta-analysis and systematic review of randomized controlled tria	13
Response to ‘25-OH Vitamin D concentrations measured by LC-MS/MS are equivalent in serum and EDTA plasma’	13
Characterization and functional analysis of BmSR-B1 for phytosterol uptake	13
TFA-mediated stereoselective aza-Michael addition for the synthesis of 3β-arylamine derivatives of withaferin A and evaluation of their anticancer potential	13
A novel role of catalase in cholesterol uptake of Helicobacter pylori	12
Nutrient manipulation regulates growth and steroidal alkaloid production in plant cultures of Solanum viarum Dunal	12
The effect of various corticosteroids in the hospitalized patients with moderate and severe COVID-19: A tertiary hospital experience	12
Polycystic ovary syndrome: Insights into its prevalence, diagnosis, and management with special reference to gut microbial dysbiosis	12
Glucocorticoid signaling and the impact of high-fat diet on adipogenesis in vivo	12
Retraction notice to “Design, synthesis and biological evaluation of betulinic acid derivatives as potential inhibitors of 3CL-protease of SARS-CoV-2“ [STE 202 (2024) 109351]	12
Filamin A in triple negative breast cancer	11
Genetic insights into vitamin D deficiency: a case-control study of GC and CYP24A1 gene polymorphism	11
European Network for oxysterol research (ENOR): 10th ENOR symposium – Web meeting	11
Endocannabinoid and steroid hormone levels during and after pregnancy in fingernail samples from mothers and their infants	11
Progestogens exhibit progestogen-, promoter- and isoform-specific effects via the progesterone receptor	11
Synthesis of hyocholic acid and its derivatization with sodium periodate to distinguish it from cholic acid by mass spectrometry	11
20-Hydroxyecdysone bioavailability and pharmacokinetics in Gerbillus tarabuli, a gerbil model for metabolic syndrome studies	10
Editorial Board	10
Investigating the influence of estrous cycle-dependent hormonal changes on neurogenesis in adult mice	10
Vitamin D potentiation of metformin hepatoprotective activities: Concurrent targeting of carbohydrate enzymatic pathways and PCSK9/AGEs-regulated oxidative stress mechanisms in type 2 diabetic male Wi	10
Antibacterial activity of withanolides and their structure-activity relationship	10
Estrogen signaling in healthy and tumor brain	10
The role of estrogen metabolites in human ovarian function	10
Shatavarin-IV, a steroidal saponin from Asparagus racemosus, inhibits cell cycle progression and epithelial-to-mesenchymal transition in AGS cells under hyperglycemic conditions	9
Editorial Board	9
Corrigendum to “Advances in the understanding of androgen receptor structure and function and in the development of next-generation AR-targeted therapeutics”. [Steroids 210 (2024) 109486]	9
Mifepristone’s effects on depression- and anxiety-like behavior in rodents	9
New secondary metabolites from the soil-derived Aspergillus versicolor QC812	9
l-arginine mitigates endocrine and spermatogenesis disruptions in cisplatin-exposed male Wistar rats by modulating iNOS/NO/NF-kB and Nrf2/HO-1 signaling	9
Anti-cancer activity, and molecular docking of novel hybrid heterocyclic steroids revealed promising anti-hepatocellular carcinoma agent: Implication of cyclin dependent kinase-2 pathway	9
Synthesis and anti-inflammatory effects of Δ7-Cholestenol and Δ8(14)-Cholestenol derivatives	9
Corrigendum to “Effects of neural-derived estradiol on actin polymerization and synaptic plasticity-related proteins in prefrontal and hippocampal cells of mice” [Steroids 177 (2022) 108935]	9
Evaluation of structural and thermodynamic insight of ERβ with DPN and derivatives through MMGBSA/MMPBSA methods	9
Kuwanon C inhibits proliferation and induction of apoptosis via the intrinsic pathway in MDA-MB231 and T47D breast cancer cells	9
A hormonal side effect of anabolic steroids among a sample of Baghdad male bodybuilders	9
Retraction notice to “Effective synthesis of a hexacycl-steroid derivative from 4-hydroxyestrone” [Steroids 163 (2020) 108715]	9
Application of a fluorine strategy in the lead optimization of betulinic acid to the discovery of potent CD73 inhibitors	9
Synthesis, NMR and X-ray characterization of dibenzoannulated dimeric steroid spiroketals. Evaluation of cytotoxicity and anti-inflammatory activity	9
Formation of nitrogen-containing six-membered heterocycles on steroidal ring system: A review	9

Testosterone replacement has a beneficial effect on the hemostatic system by altered gene expression of coagulation factors	9
An association of VDR gene polymorphism in hypovitaminosis D mediated secondary hyperparathyroidism in adolescent girls; a tertiary hospital study in central India	8
An overview on androgen-mediated actions in skeletal muscle and adipose tissue	8
A comprehensive update on phytochemistry, analytical aspects, medicinal attributes, specifications and stability of stigmasterol	8
Editorial Board	8
Natural products derived steroids as potential anti-leishmanial agents; disease prevalence, underlying mechanisms and future perspectives	8
Navigating nonalcoholic fatty liver disease (NAFLD): Exploring the roles of estrogens, pharmacological and medical interventions, and life style	8
Navigating a plethora of progesterone receptors: Comments on the safety/risk of progesterone supplementation in women with a history of breast cancer or at high-risk for developing breast cancer	8
Editorial Board	8
The effect of vitamin D2 supplementation on vitamin D levels in humans: A time and dose–response meta-analysis of randomized controlled trials	8
Dehydroepiandrosterone supplementation improves diminished ovarian reserve clinical and in silico studies	8
Steroids from the mushroom Ganoderma shandongense and their AChE inhibitory activities	8
Synthesis of fully functionalized spirostanic 1,2,3-triazoles by the three component reaction of diosgenin azides with acetophenones and aryl aldehydes and their biological evaluation as antiprolifera	8
An efficient regioconvergent synthesis of 3-aza-obeticholic acid	8
Editorial Board	8
Sonogashira coupling-based synthesis and in vitro cytotoxic evaluation of C-2 alkynyl derivatives of withaferin A	7
Design, synthesis and characterization of novel cholesterol derivatives: Anti-cancer activity, ADMET profiling and DFT insights	7
Expression of pregnenolone-synthesizing enzymes CYP11A1 and CYP1B1 in the human, rat, and mouse brain	7
The influence of the route of drug administration on the metabolic profile of trenbolone in doping control urine samples	7
Rfamide-related peptide-3(RFRP-3) receptor gene is expressed in mouse ovarian granulosa cells: Potential role of RFRP-3 in steroidogenesis and apoptosis	7
BSS-4, a diosgenin analogue, reduces carrageenan-induced paw inflammation in rat	7
Testosterone-TGF-β crosstalk modulates cell migration in human glioblastoma-derived cell lines	7
Editorial Board	7
Metabolism of progestogens used for contraception and menopausal hormone therapy	7
Structures and functions of human placental aromatase and steroid sulfatase, two key enzymes in estrogen biosynthesis	7
In vitro metabolic profiling of 6-chloro-testosterone and 6-ene-testosterone by liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-time of flight (GC-TOF) mass spectrometry	7
MiR-221-5p/Smad3 axis in osteoclastogenesis and its function: Potential therapeutic target for osteoporosis	7
Validation of a LC-MS/MS method for establishing reference intervals and assessing diagnostic performance of urinary free cortisol and cortisone	7
Microbial catalyzed derivatization of canrenone with Glomerella fusarioides, and Cunninghamella blakesleeana, and evaluation of aromatase inhibitory activity of the resulting metabolites	7
Microwave-assisted one-pot multicomponent synthesis of steroidal pyrido[2,3-d]pyrimidines and their possible implications in drug development	7
Dexamethasone induces cancer mitigation and irreversible senescence in lung cancer cells via damaging cortical actin and sustained hyperphosphorylation of pRb	6
Significance of vitamin D responsiveness on the etiology of vitamin D-related diseases	6
The interpretation of immunometric, chromatographic and mass spectrometric data for steroids in diagnosis of endocrine disorders	6
Therapeutic effects of Stemmoside C against Salmonella enterica serotype typhimurium infected BALB/c mice	6
Structural and functional characterization of genes and enzymes involved in withanolide biosynthesis in Physalis alkekengi L.	6
Potential of betulinic acid in the Antiformation and eradication of bacterial biofilms and pharmacokinetic and toxicological analysis	6
Sinulasterols D–G, four new antibacterial steroids from the South China sea soft coral Sinularia depressa	6
Current advances in phytosterol free forms and esters: Classification, biosynthesis, chemistry, and detection	6
Intramuscular sex steroid hormones are reduced after resistance training in postmenopausal women, but not affected by estrogen therapy	6
Synthesis and anticancer properties of a hybrid molecule with the testosterone and estradiol head-groups	6
The advancement of structure, bioactivity, mechanism, and synthesis of bufotalin	6
Effect of betulinic acid on MepA efflux pump inhibition in Staphylococcus aureus: Antibacterial and molecular study	6
Corticosteroids: A boon or bane for COVID-19 patients?	6
Sudanese Toombak smokeless tobacco users harbour significantly altered long–term cortisol body production	6
Understanding the role of hormones in pediatric growth: Insights from a double-debiased machine learning approach	6
Endocrine disruptors and arterial hypertension: A developing story	6
N-acetyl-cysteine alleviates nandrolone decanoate-induced hippocampal cell apoptosis in rats via reversing protein expressions of S1P1, Akt and FOXO3a signaling pathway	6
Alteration of bile acid metabolism in mice under thermoneutral conditions	6
Reaction of 7α-bromo-6-nitrocholest-5-enes with hydrazine: Formation of steroidal pyrazolines and molecular docking against SARS-CoV-2 omicron protease	6
Editorial Board	6
Editorial Board	6
The Effect of Vitamin D3 supplementation on Flunitrazepam-Induced testicular dysfunction in Wistar rats	6
Editorial Board	6
25-OH Vitamin D concentrations measured by LC-MS/MS are equivalent in serum and EDTA plasma	6
Rodent models in polycystic ovarian syndrome: Dissecting reproductive and metabolic phenotypes for therapeutic advancements	6
Tricholosterols A–D, four new ergosterol derivatives from the mushroom Tricholoma terreum	6
Practical synthesis of chenodeoxycholic acid from phocaecholic acid	6