OOIR: Observatory of International Research

Papers

(The TQCC of Steroids is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
The steroidal alkaloids α-tomatine and tomatidine: Panorama of their mode of action and pharmacological properties	41
An overview of the classical and tissue-derived renin-angiotensin-aldosterone system and its genetic polymorphisms in essential hypertension	34
Considerations, possible contraindications, and potential mechanisms for deleterious effect in recreational and athletic use of selective androgen receptor modulators (SARMs) in lieu of anabolic andro	27
An in vitro investigation of endocrine disrupting potentials of ten bisphenol analogues	24
Regulation of cholesterol biosynthesis and lipid metabolism: A microRNA management perspective	23
Enterohepatic circulation of bile acids and their emerging roles on glucolipid metabolism	22
Inhibition of EZH2 via the STAT3/HOTAIR signalling axis contributes to cell cycle arrest and apoptosis induced by polyphyllin I in human non-small cell lung cancer cells	21
Russelioside B; A pregnane glycoside for treatment of gastric ulcer via modulation of heat shock protein-70 and vascular endothelial growth factor	21
Deoxycholic acid as a molecular scaffold for tyrosyl-DNA phosphodiesterase 1 inhibition: A synthesis, structure–activity relationship and molecular modeling study	21
Hair cortisol measurement in older adults: Influence of demographic and physiological factors and correlation with perceived stress	20
The anti-androgenic effect of quercetin on hyperandrogenism and ovarian dysfunction induced in a dehydroepiandrosterone rat model of polycystic ovary syndrome	20
Organotin derivatives of cholic acid induce apoptosis into breast cancer cells and interfere with mitochondrion; Synthesis, characterization and biological evaluation	18
An insight on 7- ketocholesterol mediated inflammation in atherosclerosis and potential therapeutics	18
A review on synthesis and biological activities of D-ring modified pregnenolone	17
Genomic signaling of vitamin D	17
Effects of Cangfu Daotan Decoction on obese polycystic ovary syndrome and its mechanism	17
Synthesis of steroidal dihydropyrazole derivatives using green ZnO NPs and evaluation of their anticancer and antioxidant activity	17
Dutasteride combined with androgen receptor antagonists inhibit glioblastoma U87 cell metabolism, proliferation, and invasion capacity: Androgen regulation	17
A spirostanol saponin isolated from Tupistra chinensis Baker simultaneously induces apoptosis and autophagy by regulating the JNK pathway in human gastric cancer cells	16
Cytoprotective activities of representative nutrients from the Mediterranean diet and of Mediterranean oils against 7-ketocholesterol- and 7β-hydroxycholesterol-induced cytotoxicity: Application to ag	16
Investigation of the possible mechanism of two kinds of sterols extracted from Leucocalocybe mongolica in inducing HepG2 cell apoptosis and exerting anti-tumor effects in H22 tumor-bearing mice	15
A review on steroid dimers: 2011–2019	15
Azasteroids from diosgenin: Synthesis and evaluation of their antiproliferative activity	15
Anti-atherogenic effect of Nepitrin-7-O-glucoside: A flavonoid isolated from Nepeta hindostana via acting on PPAR – α receptor	15
Recent advances in the bile acid based conjugates/derivatives towards their gelation applications	15

The roles of methylprednisolone treatment in patients with COVID-19: A systematic review and meta-analysis	15
Anticancer potential of cardiac glycosides and steroid-azole hybrids	15
Bile acid-based receptors and their applications in recognition	14
Survey of protein-based sport supplements for illegally added anabolic steroids methyltestosterone and 4-androstenedione by UPLC-MS/MS	14
Differential off-target glucocorticoid activity of progestins used in endocrine therapy	14
Synthesis, pharmacological evaluation and Molecular modelling studies of pregnenolone derivatives as inhibitors of human dihydrofolate reductase	14
Anticancer properties of caudatin and related C-21 steroidal glycosides from Cynanchum plants	14
Linoleic acid promotes testosterone production by activating Leydig cell GPR120/ ERK pathway and restores BPA-impaired testicular toxicity	14
Increased cholesterol absorption is associated with In-stent-restenosis after stent implantation for stable coronary artery disease	14
Synthesis and antiproliferative evaluation of some novel estradiol selenocyanates	13
Novel combination of multi-walled carbon nanotubes and gold nanocomposite for photothermal therapy in human breast cancer model	13
Protective effects of milk thistle (Sylibum marianum) seed oil and α-tocopherol against 7β-hydroxycholesterol-induced peroxisomal alterations in murine C2C12 myoblasts: Nutritional insights associated	13
Effects of synthetic glucocorticoids on breast cancer progression	12
Corticosteroids: A boon or bane for COVID-19 patients?	12
Bone mineral density, trabecular bone score and muscle strength in transgender men receiving testosterone therapy versus cisgender men	12
Potential role of mycosterols in hyperlipidemia – A review	12
Stochastic dynamic mass spectrometric quantification of steroids in mixture — Part II	12
Synthesis and biological evaluation of novel steroidal pyrazole amides as highly potent anticancer agents	12
Involvement of kynurenine pathway in depressive-like behaviour induced by nandrolone decanoate in mice	12
The presence of a cationic center is not alone decisive for the cytotoxicity of triterpene carboxylic acid amides	11
Measurement of steroid hormones by liquid chromatography-tandem mass spectrometry with small amounts of hair	11
Synthesis of diosgenyl quaternary ammonium derivatives and their antitumor activity	11
Dammarane triterpenes and phytosterols from Dysoxylum tpongense Pierre and their anti-inflammatory activity against liver X receptors and NF-κB activation	11
Type and position of linkage govern the cytotoxicity of oleanolic acid rhodamine B hybrids	11
MicroRNA-23b-3p participates in steroid-induced osteonecrosis of the femoral head by suppressing ZNF667 expression	11
Synthesis and anti-inflammatory activity of novel steroidal chalcones with 3β-pregnenolone ester derivatives in RAW 264.7 cells in vitro	11
The effects of dehydroepiandrosterone (DHEA) supplementation on body composition and blood pressure: A meta-analysis of randomized clinical trials	11
Research progress in the application of bile acid-drug conjugates: A “trojan horse” strategy	10
Bioactive stigmastadienone from Isodon rugosus as potential anticholinesterase, α-glucosidase and COX/LOX inhibitor: In-vitro and molecular docking studies	10
Steroidal saponins from Raphia vinifera and their cytotoxic activity	10
Synthesis of erythrodiol C-ring derivatives and their activity against Chlamydia trachomatis	10
Cytotoxic ergostane-type steroids from Ganoderma lingzhi	10
Formation of nitrogen-containing six-membered heterocycles on steroidal ring system: A review	9
Polyhydroxylated steroids from the Vietnamese soft coral Sarcophyton ehrenbergi	9
In silico ADMET analysis of the A-, B- and D-modified androstane derivatives with potential anticancer effects	9
The effect of dehydroepiandrosterone (DHEA) supplementation on estradiol levels in women: A dose-response and meta-analysis of randomized clinical trials	9
Effects of exercise training on glucocorticoid-induced muscle atrophy: Literature review	9
Changes in conjugated urinary bile acids across age groups	9
Recent advances in chemical synthesis, biocatalysis, and biological evaluation of diosgenin derivatives – A review	9
A comprehensive update on phytochemistry, analytical aspects, medicinal attributes, specifications and stability of stigmasterol	8
Triazole-estradiol analogs: A potential cancer therapeutic targeting ovarian and colorectal cancer	8
Testicular induced corticosterone synthesis in male rats under fasting stress	8
Phytochemical Investigation, In silico/In vivo Analgesic, and Anti-inflammatory Assessment of the Egyptian Cassia occidentalis L.	8
Pd-catalyzed Suzuki–Miyaura couplings and evaluation of 13α-estrone derivatives as potential anticancer agents	8
Development of a LC-MS/MS method to measure serum 3-sulfate and 3-glucuronide 25-hydroxyvitamin D3 metabolites; comparisons to unconjugated 25OHD in pregnancy and polycystic ovary syndrome	8
Cucurbitacin E shows synergistic effect with sorafenib by inducing apoptosis in hepatocellular carcinoma cells and regulates Jak/Stat3, ERK/MAPK, PI3K/Akt/mTOR signaling pathways	8
Novel mutations of the CYP17A1 gene in four Chinese 46,XX cases with partial 17a-hydroxylase/17,20-lyase deficiency	8
Vascular endothelial dysfunction in gestational diabetes mellitus	7
The effect of transdermal 17β-estradiol combined with norethisterone acetate treatment on the lipid profile in postmenopausal women: A meta-analysis and systematic review of randomized controlled tria	7
Corticosterone rapidly reduces glutamatergic but not GABAergic transmission in the infralimbic prefrontal cortex of male mice	7

Phoenix dactylifera L. date tree pollen fertility effects on female rats in relation to its UPLC-MS profile via a biochemometric approach	7
Mass spectrometric stochastic dynamic 3D structural analysis of mixture of steroids in solution – Experimental and theoretical study	7
PDIA3 modulates genomic response to 1,25-dihydroxyvitamin D3 in squamous cell carcinoma of the skin	7
Research progress of diosgenin extraction from Dioscorea zingiberensis C. H. Wright: Inspiration of novel method with environmental protection and efficient characteristics	7
A pseudo-targeted metabolomics study based on serum bile acids profiling for the differential diagnosis of benign and malignant breast lesions	7
Synthesis of human long-term metabolites of dehydrochloromethyltestosterone and oxymesterone	7
Steroidal alkaloids and their glycosides from the bulbs of Fritillaria unibracteata	7
Microwave-assisted one-pot multicomponent synthesis of steroidal pyrido[2,3-d]pyrimidines and their possible implications in drug development	7
DG-8d, a novel diosgenin derivative, decreases the proliferation and induces the apoptosis of A549 cells by inhibiting the PI3k/Akt signaling pathway	7
Sensitive and selective simultaneous biosensing of nandrolone and testosterone as two anabolic steroids by a novel biosensor assisted by second-order calibration	7
C21, C22 pregnane glycosides and cytotoxic C27 spriostanol steroids from Asparagus cochinchinesis	7
Synthesis and biological evaluation of 17-cyanopyridine derivatives of pregnenolone as potential anti-prostate cancer agents	7
Impaired attention in patients with adrenal insufficiency – Impact of unphysiological therapy	7
Arthriniumsteroids A–D, four new steroids from the soft coral-derived fungus Simplicillium lanosoniveum SCSIO41212	7
Synthesis, antifungal evaluation, and molecular docking studies of steroidal thiazolopyrimidines	7
Synthesis and biological in vitro evaluation of the effect of hydroxyimino steroidal derivatives on breast cancer cells	7
Structures and functions of human placental aromatase and steroid sulfatase, two key enzymes in estrogen biosynthesis	7
Circulating steroids and mood disorders in patients with polycystic ovary syndrome	7
Antiproliferative activity of standardized phytopreparations from Ibervillea sonorae (S. Watson) Greene	7
Detection of DHCMT long-term metabolite glucuronides with LC-MSMS as an alternative approach to conventional GC-MSMS analysis	6
Steroid profile in dried blood spots by liquid chromatography tandem mass spectrometry: Application to newborn screening for congenital adrenal hyperplasia in China	6
Therapeutic effects of Stemmoside C against Salmonella enterica serotype typhimurium infected BALB/c mice	6
Anabolic-androgenic steroids impair mitochondrial function and redox status in the heart and liver of mice	6
Influence of synthetic isoflavones on selected urinary steroid biomarkers: Relevance to doping control	6
Functions of dehydroepiandrosterone in relation to breast cancer	6
Navigating nonalcoholic fatty liver disease (NAFLD): Exploring the roles of estrogens, pharmacological and medical interventions, and life style	6
Association of genetic polymorphisms with local steroid metabolism in human benign breasts	6
Efficient access to domain-integrated estradiol-flavone hybrids via the corresponding chalcones and their in vitro anticancer potential	6
Fat mass and obesity-associated gene expression and disease severity in type 2 diabetes mellitus	6
Regulation of phase I and phase II neurosteroid enzymes in the hippocampus of an Alzheimer’s disease rat model: A focus on sulphotransferases and UDP-glucuronosyltransferases	6
Pathology of hyperandrogenemia in the oocyte of polycystic ovary syndrome	6
Protective effects of combining SERMs with estrogen on metabolic parameters in postmenopausal diabetic cardiovascular dysfunction: The role of cytokines and angiotensin II	6
A synthesis of a rationally designed inhibitor of cytochrome P450 8B1, a therapeutic target to treat obesity	6
Synthesis of 16β-derivatives of 3-(2-bromoethyl)-estra-1,3,5(10)-trien-17β-ol as inhibitors of 17β-HSD1 and/or steroid sulfatase for the treatment of estrogen-dependent diseases	6
Steroid-triazole conjugates: A brief overview of synthesis and their application as anticancer agents	6
Large-scale synthesis of galeterone and lead next generation galeterone analog VNPP433-3β	6
The combined effects of treadmill exercise and steroid administration on anterior cruciate ligament reconstruction-induced joint contracture and muscle atrophy in rats	6
Anti-inflammatory pregnane-type steroid derivatives clathroids A-B from the marine Microcionidae sponge Clathria (Thalysias) vulpina: Prospective duel inhibitors of pro-inflammatory cyclooxygenase-2 a	6
The role of progesterone receptor membrane component (PGRMC) in the endometrium	6
Association between LINC-PINT and LINC00599 gene polymorphism and the risk of steroid-induced osteonecrosis of the femoral head in the population of northern China	6
Steroid sulfatase in the mouse NIH-3T3 fibroblast cell line: Characterization, and downregulation by glucocorticoids	6
Natural products derived steroids as potential anti-leishmanial agents; disease prevalence, underlying mechanisms and future perspectives	6
Molecular docking simulation and in vitro studies on estrogenic activities of flavonoids from leaves of Carya cathayensis Sarg	6
Design and synthesis of hetero-steroids via ring-closing metathesis: Biological studies towards in vitro anticancer activity	6
Does letrozole treatment have favorable effects on the lipid profile? A systematic review and meta-analysis of randomized clinical trials	5
Synthesis of aminoacylated ergosterols: A new lipid component of fungi	5
Govanosides C-F, unprecedented steroidal saponins with rare sugars from rhizomes of Trillium govanianum and their antagonistic effects on acetylcholinesterase	5
Separation and identification of tubocapsanolide MAP and tubocapsunolide A, and the structure-activity relationship of their anti-TNBC activity	5
Synthesis and antitumor activity of some cholesterol-based selenocyanate compounds	5
Anti-diabetic effects of fungal Ergosta-4, 6, 8(14), 22-tetraen-3-one from Pholiota adiposa	5
Salivary testosterone, testosterone/cortisol ratio and non-verbal behavior in stress	5
Anti-inflammatory β-sitosterols from the Asiatic loop-root mangrove Rhizophora mucronata attenuate 5-lipoxygenase and cyclooxygenase-2 enzymes	5
Design, synthesis and anti-tumor activities of carbamate derivatives of cinobufagin	5
Adrenocorticotropic hormone: An expansion of our current understanding of the treatment for nephrotic syndrome	5
Preparation and cytotoxic evaluation of new steroidal oximes and aza-homosteroids from diosgenin and cholesterol	5
High, not low-dose of stanozolol (Anabolic – androgenic steroid) impedes embryo implantation by attenuating endometrial receptivity in the mouse, Mus musculus	5
Synthesis and biological activities of bicyclic pyridines integrated steroid hybrid	5
T-17, a spirostanol saponin, inhibits p53-independent proliferation and p53-dependent migration of gastric cancer cells	5
3-Hexanoyl-7-nitrobenz-2-oxa-1,3-diazol-4-yl-cholesterol (3-NBD-cholesterol) is a versatile cholesterol tracer	5
Anti-cancer activity, and molecular docking of novel hybrid heterocyclic steroids revealed promising anti-hepatocellular carcinoma agent: Implication of cyclin dependent kinase-2 pathway	5
Anticholinesterase and anti-inflammatory constituents from Caralluma awdeliana, a medicinal plant from Yemen	5
A sensitive, precise and rapid LC–MS/MS method for determination of ergosterol peroxide in Paecilomyces cicadae mycelium	5
Global effects of pharmacologic inhibition of OSBP in human umbilical vein endothelial cells	5
Antioxidant activity of novel diosgenin derivatives: Synthesis, biological evaluation, and in silico ADME prediction	5