Science

Article	Citations
Accurate prediction of protein structures and interactions using a three-track neural network	3383
Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection	2160
Copper induces cell death by targeting lipoylated TCA cycle proteins	2070
Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England	1977
The complete sequence of a human genome	1556
The world of two-dimensional carbides and nitrides (MXenes)	1547
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity	1467
Quantum computational advantage using photons	1387
Monolithic perovskite/silicon tandem solar cell with >29% efficiency by enhanced hole extraction	1315
An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19	1247
Evolutionary-scale prediction of atomic-level protein structure with a language model	1231
The global threat from plastic pollution	1224
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis	1087
Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil	1045
Conformal quantum dot–SnO 2 layers as electron transporters for efficient perovskite solar cells	1023
Neuropilin-1 is a host factor for SARS-CoV-2 infection	995
Robust neutralizing antibodies to SARS-CoV-2 infection persist for months	993
Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients	891
Inactive (PbI 2 ) 2 RbCl stabilizes perovskite films for efficient solar cells	887
Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients	879
Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans	863
Airborne transmission of respiratory viruses	837
Semiconductor quantum dots: Technological progress and future challenges	811
Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial	805
Material-structure-performance integrated laser-metal additive manufacturing	790

Rational design of layered oxide materials for sodium-ion batteries	782
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo	775
Exceeding 1.5°C global warming could trigger multiple climate tipping points	757
Inferring the effectiveness of government interventions against COVID-19	723
Microplastics and human health	716
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans	710
CO 2 electrolysis to multicarbon products in strong acid	702
High-entropy-stabilized chalcogenides with high thermoelectric performance	687
Prospective mapping of viral mutations that escape antibodies used to treat COVID-19	675
ChatGPT is fun, but not an author	672
A rechargeable zinc-air battery based on zinc peroxide chemistry	663
A ubiquitous tire rubber–derived chemical induces acute mortality in coho salmon	652
Organometallic-functionalized interfaces for highly efficient inverted perovskite solar cells	650
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern	637
The microbiome and human cancer	629
Pan-cancer single-cell landscape of tumor-infiltrating T cells	619
Per- and polyfluoroalkyl substances in the environment	603
Global food system emissions could preclude achieving the 1.5° and 2°C climate change targets	602
CAR T cells produced in vivo to treat cardiac injury	595
Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings	590
Model-informed COVID-19 vaccine prioritization strategies by age and serostatus	586
Constructing heterojunctions by surface sulfidation for efficient inverted perovskite solar cells	577
Fracture, fatigue, and friction of polymers in which entanglements greatly outnumber cross-links	576
Stabilizing black-phase formamidinium perovskite formation at room temperature and high humidity	570
Reversible planar gliding and microcracking in a single-crystalline Ni-rich cathode	556
Hierarchical-morphology metafabric for scalable passive daytime radiative cooling	548
Robust deep learning–based protein sequence design using ProteinMPNN	545
The immunology and immunopathology of COVID-19	530
Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa	528
Stabilizing perovskite-substrate interfaces for high-performance perovskite modules	523
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms	521
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity	504
Carbon-free high-loading silicon anodes enabled by sulfide solid electrolytes	501
Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms	500
SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex	500
Self-assembled monolayers direct a LiF-rich interphase toward long-life lithium metal batteries	493
A human cell atlas of fetal gene expression	489
Scalable thermochromic smart windows with passive radiative cooling regulation	484
Poverty, depression, and anxiety: Causal evidence and mechanisms	477
Damp heat–stable perovskite solar cells with tailored-dimensionality 2D/3D heterojunctions	475
Biphenylene network: A nonbenzenoid carbon allotrope	468
Terrestrial radiative cooling: Using the cold universe as a renewable and sustainable energy source	463
REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters	461
Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants	456
Sulfur-anchoring synthesis of platinum intermetallic nanoparticle catalysts for fuel cells	455
The soundscape of the Anthropocene ocean	451
Early detection of cancer	448
Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response	447
Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape	446
Stacking-engineered ferroelectricity in bilayer boron nitride	444

Accurate proteome-wide missense variant effect prediction with AlphaMissense	442
Lead halide–templated crystallization of methylamine-free perovskite for efficient photovoltaic modules	440
Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 vaccine–elicited human sera	431
Tertiary lymphoid structures in cancer	431
Tough hydrogels with rapid self-reinforcement	426
Chiral-induced spin selectivity enables a room-temperature spin light-emitting diode	423
Nanomesh pressure sensor for monitoring finger manipulation without sensory interference	422
Grassland soil carbon sequestration: Current understanding, challenges, and solutions	418
Miniaturization of optical spectrometers	417
Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement	416
Realization of a multinode quantum network of remote solid-state qubits	414
mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection	410
Haplotype-resolved diverse human genomes and integrated analysis of structural variation	406
A scalable metal-organic framework as a durable physisorbent for carbon dioxide capture	405
Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic	398
Artificial multimodal receptors based on ion relaxation dynamics	397
Cross-tissue immune cell analysis reveals tissue-specific features in humans	396
Gradient cell–structured high-entropy alloy with exceptional strength and ductility	395
Estimating infectiousness throughout SARS-CoV-2 infection course	395
Recent global decline of CO 2 fertilization effects on vegetation photosynthesis	390
Critical instability at moving keyhole tip generates porosity in laser melting	389
Enhanced atomic ordering leads to high thermoelectric performance in AgSbTe 2	385
Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly	384
Ultrahigh energy storage in superparaelectric relaxor ferroelectrics	383
High-strength scalable MXene films through bridging-induced densification	383
Hierarchical crack buffering triples ductility in eutectic herringbone high-entropy alloys	381
Interfacial toughening with self-assembled monolayers enhances perovskite solar cell reliability	379
A massive rock and ice avalanche caused the 2021 disaster at Chamoli, Indian Himalaya	378
Plastics in the Earth system	374
Probing topological spin liquids on a programmable quantum simulator	374
CRISPR technology: A decade of genome editing is only the beginning	371
High-entropy nanoparticles: Synthesis-structure-property relationships and data-driven discovery	366
The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans	364
Toward polymer upcycling—adding value and tackling circularity	364
Nitrogen reduction to ammonia at high efficiency and rates based on a phosphonium proton shuttle	360
Epidemiology and transmission dynamics of COVID-19 in two Indian states	359
Structural impact on SARS-CoV-2 spike protein by D614G substitution	358
Computed structures of core eukaryotic protein complexes	358
Evolution of water structures in metal-organic frameworks for improved atmospheric water harvesting	357
Temperature-adaptive radiative coating for all-season household thermal regulation	357
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling	354
Manipulating matter by strong coupling to vacuum fields	353
Cell-free chemoenzymatic starch synthesis from carbon dioxide	352
Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein	351
Sabatier principle of metal-support interaction for design of ultrastable metal nanocatalysts	349
Interfacial ferroelectricity by van der Waals sliding	348
Minimizing buried interfacial defects for efficient inverted perovskite solar cells	347
SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model	347
De novo assembly, annotation, and comparative analysis of 26 diverse maize genomes	345
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike	343
Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma	338
SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern	338
Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies	338
High-precision measurement of the W boson mass with the CDF II detector	336
Power generation and thermoelectric cooling enabled by momentum and energy multiband alignments	336
High figure-of-merit and power generation in high-entropy GeTe-based thermoelectrics	333
Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice	331
Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer	331
Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK	330
Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ	329
Assessing China’s efforts to pursue the 1.5°C warming limit	327
Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme	323
Ultrahard magnetism from mixed-valence dilanthanide complexes with metal-metal bonding	320
Topological supramolecular network enabled high-conductivity, stretchable organic bioelectronics	320
Solvation sheath reorganization enables divalent metal batteries with fast interfacial charge transfer kinetics	320
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring	318
Signaling inflammation across the gut-brain axis	315
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape	314
Memristive technologies for data storage, computation, encryption, and radio-frequency communication	314
Immunological characteristics govern the transition of COVID-19 to endemicity	313
Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2	311
Soil microbiota as game-changers in restoration of degraded lands	310
Developmental cell programs are co-opted in inflammatory skin disease	309
A brain-computer interface that evokes tactile sensations improves robotic arm control	309
Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity	307
Broad betacoronavirus neutralization by a stem helix–specific human antibody	306
A human cell atlas of fetal chromatin accessibility	304
Transmission heterogeneities, kinetics, and controllability of SARS-CoV-2	304
Stretchable distributed fiber-optic sensors	304
Protein condensates as aging Maxwell fluids	302

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants	302
Nanoscale localized contacts for high fill factors in polymer-passivated perovskite solar cells	297
Detection of two interstellar polycyclic aromatic hydrocarbons via spectral matched filtering	296
Human impacts on global freshwater fish biodiversity	296
Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate	296
Fire and biodiversity in the Anthropocene	295
Electric field–tunable superconductivity in alternating-twist magic-angle trilayer graphene	295
Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine–elicited human sera	295
Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody	293
Socioeconomic status determines COVID-19 incidence and related mortality in Santiago, Chile	290
Past climates inform our future	289
Cryo-EM structures of amyloid-β 42 filaments from human brains	289
SARS-CoV-2 within-host diversity and transmission	289
Achieving net-zero greenhouse gas emission plastics by a circular carbon economy	288
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis	288
Nervous system consequences of COVID-19	287
Three-dimensional capillary ratchet-induced liquid directional steering	285
Rethinking the A cation in halide perovskites	285
Large-area low-noise flexible organic photodiodes for detecting faint visible light	283
Gene regulatory networks controlling vertebrate retinal regeneration	282
The biodiversity and ecosystem service contributions and trade-offs of forest restoration approaches	279
Daily energy expenditure through the human life course	274
Chemically recyclable thermoplastics from reversible-deactivation polymerization of cyclic acetals	272
Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery	270
Metastable Dion-Jacobson 2D structure enables efficient and stable perovskite solar cells	270
The spectrum of inflammatory responses	270
Multimessenger constraints on the neutron-star equation of state and the Hubble constant	269
Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders	268
Liquid medium annealing for fabricating durable perovskite solar cells with improved reproducibility	267
Arene diversification through distal C(sp 2 )−H functionalization	267
Materials challenges and opportunities for quantum computing hardware	267
Complete genomic and epigenetic maps of human centromeres	266
Globally observed trends in mean and extreme river flow attributed to climate change	266
Rational design of Lewis base molecules for stable and efficient inverted perovskite solar cells	265
Immune boosting by B.1.1.529 ( Omicron) depends on previous SARS-CoV-2 exposure	263
Nematicity and competing orders in superconducting magic-angle graphene	262
Mapping the proteo-genomic convergence of human diseases	261
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease	260
Copper-induced cell death	259
Multiple rereads of single proteins at single–amino acid resolution using nanopores	258
Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose	258
Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders	257
Deterministic fabrication of 3D/2D perovskite bilayer stacks for durable and efficient solar cells	256
OpenCell: Endogenous tagging for the cartography of human cellular organization	255
Face masks effectively limit the probability of SARS-CoV-2 transmission	255
Three-dimensional direct lithography of stable perovskite nanocrystals in glass	252
Direct synthesis and chemical vapor deposition of 2D carbide and nitride MXenes	252
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A	251
Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity	251
Scaffolding protein functional sites using deep learning	251
Mapping the global threat of land subsidence	251
Reducing nonradiative recombination in perovskite solar cells with a porous insulator contact	251
Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study	250
Abating ammonia is more cost-effective than nitrogen oxides for mitigating PM 2.5 air pollution	250
Designing better electrolytes	245
High thermoelectric performance realized through manipulating layered phonon-electron decoupling	245
Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging	244
Plant “helper” immune receptors are Ca 2+ -permeable nonselective cation channels	244
Tissue geometry drives deterministic organoid patterning	244
Bioadhesive ultrasound for long-term continuous imaging of diverse organs	243
Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease	243
Highly efficient p-i-n perovskite solar cells that endure temperature variations	240
Age groups that sustain resurging COVID-19 epidemics in the United States	239
Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates	239
Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells	239
Machine learning–enabled high-entropy alloy discovery	237
Cross-reactive CD4 + T cells enhance SARS-CoV-2 immune responses upon infection and vaccination	237
Hybrid immunity	236
A hydrophobic FeMn@Si catalyst increases olefins from syngas by suppressing C1 by-products	236
Capturing the swelling of solid-electrolyte interphase in lithium metal batteries	235
Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant	235
Mixed plastics waste valorization through tandem chemical oxidation and biological funneling	234
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women	234
Highly conductive and elastic nanomembrane for skin electronics	234
Realizing topologically ordered states on a quantum processor	233
Geometric deep learning of RNA structure	232
Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles	232
The genetic and epigenetic landscape of the Arabidopsis centromeres	232
Microbiota and maintenance of skin barrier function	230
Neuromorphic sensorimotor loop embodied by monolithically integrated, low-voltage, soft e-skin	230
Big-data approaches lead to an increased understanding of the ecology of animal movement	230
Nanoscale control of internal inhomogeneity enhances water transport in desalination membranes	229
A global transition to flash droughts under climate change	229
Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems	229
Competition-level code generation with AlphaCode	229
Monolithic optical microlithography of high-density elastic circuits	228
HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells	227
Seroprevalence of anti–SARS-CoV-2 IgG antibodies in Kenyan blood donors	227
Spatiotemporal pattern of COVID-19 spread in Brazil	227
Quantum walks on a programmable two-dimensional 62-qubit superconducting processor	226
Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody	224
Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function	224
Plastic ingestion as an evolutionary trap: Toward a holistic understanding	223
Clinically relevant mutations in core metabolic genes confer antibiotic resistance	222
La- and Mn-doped cobalt spinel oxygen evolution catalyst for proton exchange membrane electrolysis	222