OOIR: Observatory of International Research

Papers

(The TQCC of Planta Medica is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Rosmarinic Acid–Human Pharmacokinetics and Health Benefits	79
Artemisia annua – Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications	34
Quality Control of Herbal Medicines: From Traditional Techniques to State-of-the-art Approaches	33
Medicinal Plants in the Treatment of Depression: Evidence from Preclinical Studies	32
Antiviral and Virucidal Properties of Essential Oils and Isolated Compounds – A Scientific Approach	27
Cannabis sativa and Skin Health: Dissecting the Role of Phytocannabinoids	25
Natural Products as a Source of Inspiration for Novel Inhibitors of Advanced Glycation Endproducts (AGEs) Formation	22
Lichen Depsidones with Biological Interest	20
Medicinal Plants for Insomnia Related to Anxiety: An Updated Review	18
A Review of the Phytochemistry, Traditional Uses and Biological Activities of the Essential Oils of Genus Teucrium	18
Beta-Glucuronidase Inhibition by Constituents of Mulberry Bark	16
Nanoencapsulation of Plant Volatile Organic Compounds to Improve Their Biological Activities	15
Brown-Algae Polysaccharides as Active Constituents against Nonalcoholic Fatty Liver Disease	15
Phyllobilins – Bioactive Natural Products Derived from Chlorophyll – Plant Origins, Structures, Absorption Spectra, and Biomedical Properties	13
HPLC-UV, Metabarcoding and Genome Skims of Botanical Dietary Supplements: A Case Study in Echinacea	13
Erianthridin Induces Non-small Cell Lung Cancer Cell Apoptosis through the Suppression of Extracellular Signal-regulated Kinase Activity	12
Medicinal Plants in the Treatment of Depression. II: Evidence from Clinical Trials	12
Novel Insights into Pyrrolizidine Alkaloid Toxicity and Implications for Risk Assessment: Occurrence, Genotoxicity, Toxicokinetics, Risk Assessment–A Workshop Report	12
Enhanced Oral Bioavailability and Improved Biological Activities of a Quercetin/Resveratrol Combination Using a Liquid Self-Microemulsifying Drug Delivery System	12
Berberine Regulates GPX4 to Inhibit Ferroptosis of Islet β Cells	11
Kratom (Mitragyna speciosa) Validation: Quantitative Analysis of Indole and Oxindole Alkaloids Reveals Chemotypes of Plants and Products	11
Review of Studies on Phlomis and Eremostachys Species (Lamiaceae) with Emphasis on Iridoids, Phenylethanoid Glycosides, and Essential Oils	11
A Novel Peptide Derived from Ginger Induces Apoptosis through the Modulation of p53, BAX, and BCL2 Expression in Leukemic Cell Lines	11
A Proposal Towards a Rational Classification of the Antimicrobial Activity of Acetone Tree Leaf Extracts in a Search for New Antimicrobials	11
Regulatory Perspectives of Pyrrolizidine Alkaloid Contamination in Herbal Medicinal Products	11

The Potential Application of Pentacyclic Triterpenoids in the Prevention and Treatment of Retinal Diseases	10
Anticancer Potential of Compounds from the Brazilian Blue Amazon	10
New Pyrrolobenzoxazine Sesquiterpenoid Derivatives from the Fungus Talaromyces trachyspermus	10
Cytotoxicity and Antiviral Activities of Haplophyllum tuberculatum Essential Oils, Pure Compounds, and Their Combinations against Coxsackievirus B3 and B4	9
Artocarpus lacucha Extract and Oxyresveratrol Inhibit Glucose Transporters in Human Intestinal Caco-2 Cells	9
Pyrrolizidine Alkaloid Contamination in Medicinal Plants: Regulatory Requirements and Their Impact on Production and Quality Control of Herbal Medicinal Products	9
Optimization and Evaluation of Self-nanoemulsifying Drug Delivery System for Enhanced Bioavailability of Plumbagin	9
cis-Aconitic Acid, a Constituent of Echinodorus grandiflorus Leaves, Inhibits Antigen-Induced Arthritis and Gout in Mice	9
Berberine Ameliorates Glucose Metabolism in Diabetic Rats through the alpha7 Nicotinic Acetylcholine Receptor-Related Cholinergic Anti-Inflammatory Pathway	9
Novel Piperidine and 3,4-dihydro-2H-pyrrole Alkaloids from Tilia platyphyllos and Tilia cordata Flowers	9
Pressurized Natural Deep Eutectic Solvent Extraction of Galanthamine and Related Alkaloids from Narcissus pseudonarcissus	9
Ethnoveterinary Remedies Used in Avian Complementary Medicine in Selected Communal Areas in Zimbabwe	9
Rhytidhyesters A – D, 4 New Chlorinated Cyclopentene Derivatives from the Endophytic Fungus Rhytidhysteron sp. BZM-9	9
Low Piperine Fractional Piper nigrum Extract Enhanced the Antitumor Immunity via Regulating the Th1/Th2/Treg Cell Subsets on NMU-Induced Tumorigenesis Rats	9
13C NMR Dereplication Using MixONat Software: A Practical Guide to Decipher Natural Products Mixtures	9
Beyond the Psychoactive Effects of Ayahuasca: Cultural and Pharmacological Relevance of Its Emetic and Purging Properties	8
Critical Assessment of In Vitro Screening of α-Glucosidase Inhibitors from Plants with Acarbose as a Reference Standard	8
A Detailed View on the Proanthocyanidins in Ginkgo Extract EGb 761	8
In Vitro and In Silico Evaluation of ACE2 and LOX Inhibitory Activity of Origanum Essential Oils and Carvacrol	8
Phloridzin Highly Accumulated in Malus rockii Rehder and Its Structure Revision and Hypolipidemic Activity	8
Folklore, Animal Self-Medication, and Phytotherapy–Something Old, Something New, Something Borrowed, Some Things True	8
Protection of Beta Boswellic Acid against Streptozotocin-induced Alzheimerʼs Model by Reduction of Tau Phosphorylation Level and Enhancement of Reelin Expression	8
Identification and Quantification of Polymethoxylated Flavonoids in Different Citrus Species Using UPLC-QTOF-MS/MS and HPLC-DAD	8
Coffee Leaves: An Upcoming Novel Food?	8
Bioaccessibility and Absorption of Flavonoid C-glycosides from Abrus mollis Using Simulated Digestion, Caco-2 Cell, and In Situ Single-pass Perfusion Models	8
Molecular Networking Discloses the Chemical Diversity of Flavonoids and Selaginellins in Selaginella convoluta	8
Inhibition of Proinflammatory Cytokine Release by Flavones and Flavanones from the Leaves of Dracaena steudneri Engl.	7
Medical Devices Made of Substances: Possible Innovation and Opportunities for Complex Natural Products	7
Medicinal Plants for the Treatment of Mental Diseases in Pregnancy: An In Vitro Safety Assessment	7
Cytotoxic Agents in the Minor Alkaloid Groups of the Amaryllidaceae	7
Total Flavonoids of Bidens pilosa Ameliorates Bone Destruction in Collagen-Induced Arthritis	7
Antiprotozoal activities of Triterpenic Acids and Ester Derivatives Isolated from the Leaves of Vitellaria paradoxa	7
Undescribed C-Glycosylflavones from Corn Silk and Potential Anti-inflammatory Activity Evaluation of Isolates	7
Sulfation of Quercitrin, Epicatechin and Rutin by Human Cytosolic Sulfotransferases (SULTs): Differential Effects of SULT Genetic Polymorphisms	7
Extraction, Purification, Quantification, and Stability of Bioactive Spilanthol from Acmella oleracea	7
Cardiovascular Effects Induced by Fruit Peels from Passiflora edulis in Hypertensive Rats and Fingerprint Analysis by HPLC-ESI-MSn spectrometry	7
Bulbine natalensis (currently Bulbine latifolia) and select bulbine knipholones modulate the activity of AhR, CYP1A2, CYP2B6, and P-gp	7
Scutellaria baicalensis Pith-decayed Root Inhibits Macrophage-related Inflammation Through the NF-κB/NLRP3 Pathway to Alleviate LPS-induced Acute Lung Injury	7
Resveratrol Protects BEAS-2B Cells against Erastin-Induced Ferroptosis through the Nrf2/Keap1 Pathway	7
Activity of THC, CBD, and CBN on Human ACE2 and SARS-CoV1/2 Main Protease to Understand Antiviral Defense Mechanism	6
Cytotoxic, Antioxidant, and Antidiabetic Activities versus UPLC-ESI-QTOF-MS Chemical-Profile Analysis of Ipomoea aquatica Fractions	6
Oxidized Forms of Olive Oil Secoiridoids: Semisynthesis, Identification and Correlation with Quality Parameters	6
The Role of Kinetics as Key Determinant in Toxicity of Pyrrolizidine Alkaloids and Their N-Oxides	6
Cornus sanguinea Fruits: a Source of Antioxidant and Antisenescence Compounds Acting on Aged Human Dermal and Gingival Fibroblasts	6
Phytogenic Compounds for Enhancing Intestinal Barrier Function in Poultry–A Review	6
Pharmacokinetic Properties of Moracin C in Mice	6
Acrotrione B, a Prenylated and Highly Oxidized Xanthenoid with Antibacterial and Anti-proliferative Activities from the Roots of Acronychia pedunculata	6
Binary Synergistic Combinations of Lavender and Fennel Essential Oils with Amoxicillin	6
Development, Validation and Application of a UHPLC-MS Method for the Quantification of Chios Mastic Gum Triterpenoids in Human Plasma	6
Hydroalcoholic Extract of Myrcia bella Loaded into a Microemulsion System: A Study of Antifungal and Mutagenic Potential	6

The Potential of Biologically Active Brazilian Plant Species as a Strategy to Search for Molecular Models for Mosquito Control	6
Quantitative Proteomics Based on iTRAQ Reveal that Nitidine Chloride Induces Apoptosis by Activating JNK/c-Jun Signaling in Hepatocellular Carcinoma Cells	5
Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2	5
Cytochalasan Alkaloids as TRAIL Sensitizers from an Endophytic Fungus Chaetomium sp.	5
Placental Passage of Protopine in an Ex Vivo Human Perfusion System	5
Chemical Constituents of Ulmus minor subsp. minor Fruits Used in the Italian Phytoalimurgic Tradition and Their Anti-inflammatory Activity Evaluation	5
Pharmacokinetics of Five Alkaloids and their Metabolites in Normal and Diabetic Rats after Oral Administration of Rhizoma coptidis	5
The Anti-inflammatory Effects of Isoflavonoids from Radix Astragali in Hepatoprotective Potential against LPS/D-gal-induced Acute Liver Injury	5
Characterization of Different Forms of Kava (Piper methysticum) Products by UPLC-MS/MS	5
(−)-Epicatechin Reverses Glucose Intolerance in Rats Housed at Thermoneutrality	5
Natural Prenylated Xanthones as Potential Inhibitors of PI3k/Akt/mTOR Pathway in Triple Negative Breast Cancer Cells	5
Evaluation of Cocoa Bean Shell Antimicrobial Activity: A Tentative Assay Using a Metabolomic Approach for Active Compound Identification	5
Medicinal Plants for Prophylaxis and Therapy of Common Infectious Diseases In Poultry–A Systematic Review of In Vivo Studies	5
Influence of Flaxseed (Linum usitatissimum) on Female Reproduction	5
Quality Requirements for Medicinal Cannabis and Respective Products in the European Union – Status Quo	5
Raw and Wine Processed Schisandra chinensis Regulate NREM-Sleep and Alleviate Cardiovascular Dysfunction Associated with Insomnia by Modulating HPA Axis	5
Withanolides from Withania somnifera Ameliorate Neutrophil Infiltration in Endotoxin-Induced Peritonitis by Regulating Oxidative Stress and Inflammatory Cytokines	5
Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes	5
Quantification of Silymarin in Silybi mariani fructus: Challenging the Analytical Performance of Benchtop vs. Handheld NIR Spectrometers on Whole Seeds	5
Cytotoxicity of Poupartone B, an Alkyl Cyclohexenone Derivative from Poupartia borbonica, against Human Cancer Cell Lines	5
Safety of Cranberry: Evaluation of Evidence of Kidney Stone Formation and Botanical Drug-Interactions	5
Bio-evaluation of Untapped Alkaloids from Vinca minor Enriched by Methyl-jasmonate-induced Stress: an Integrated Approach	5
Update on Phytochemical and Biological Studies on Rocaglate Derivatives from Aglaia Species	5
Herbal Products and Their Active Constituents Used Alone and in Combination with Antibiotics against Multidrug-Resistant Bacteria	5
Accumulation of the Major Components from Polygoni Multiflori Radix in Liver and Kidney after Its Long-Term Oral Administrations in Rats	5
White Sage (Salvia apiana)–a Ritual and Medicinal Plant of the Chaparral: Plant Characteristics in Comparison with Other Salvia Species	4
Seven-day Oral Intake of Orthosiphon stamineus Leaves Infusion Exerts Antiadhesive Ex Vivo Activity Against Uropathogenic E. coli in Urine Samples	4
Exploring Immune Modulatory Effects of Cyclotide-Enriched Viola tricolor Preparations	4
Biochemometric Analysis of Fatty Acid Amide Hydrolase Inhibition by Echinacea Root Extracts	4
1′-Acetoxychavicol Acetate from Alpinia galanga Represses Proliferation and Invasion, and Induces Apoptosis via HER2-signaling in Endocrine-Resistant Breast Cancer Cells	4
Studies on Bignoniaceae: Newbouldiosides D – F, Minor Phenylethanoid Glycosides from Newbouldia laevis, and New Flavonoids from Markhamia zanzibarica and Spathodea campanulata	4
A Systematic Review of the Potential Effects of Propolis Extracts on Experimentally-induced Diabetes	4
Molecular Farming Strategy for the Rapid Production of Protein-Based Reagents for Use in Infectious Disease Diagnostics	4
Effect of Gut Microbiota on the Metabolism of Chemical Constituents of Berberis kansuensis Extract Based on UHPLC-Orbitrap-MS Technique	4
Desmethylbellidifolin Attenuates Dextran Sulfate Sodium-Induced Colitis: Impact on Intestinal Barrier, Intestinal Inflammation and Gut Microbiota	4
Development and Validation of a Species-specific PCR Method for the Identification of Ginseng Species Using Orthogonal Approaches	4
Correction: VC8 Gaseous methyl jasmonate can increase hypericins content in Hypericum perforatum aseptic plants	4
Prenylated Acylphloroglucinols from Hypericum jovis with Anti-inflammatory Potential	4
Peperomin E Induces Apoptosis and Cytoprotective Autophagy in Human Prostate Cancer DU145 Cells In Vitro and In Vivo	4
Inactivation of Herpes Simplex Virus by Photosensitizing Anthraquinones Isolated from Heterophyllaea pustulata	4
Ouratea spectabilis and its Biflavanone Ouratein D Exert Potent Anti-inflammatory Activity in MSU Crystal-induced Gout in Mice	4
Cardioprotective Function of Green Rooibos (Aspalathus linearis) Extract Supplementation in Ex Vivo Ischemic Prediabetic Rat Hearts	4
The Role of Herbal Medicine in Cholangiocarcinoma Control: A Systematic Review	4
(+)-Magnolin Enhances Melanogenesis in Melanoma Cells and Three-Dimensional Human Skin Equivalent; Involvement of PKA and p38 MAPK Signaling Pathways	4
Screening of Antimicrobial Activity of Essential Oils against Bovine Respiratory Pathogens – Focusing on Pasteurella multocida	4
Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia	4
New Sulfoxide-Containing Derivatives from the Resin of Ferula sinkiangensis	4
Neuroprotective Properties of Chlorogenic Acid and 4,5-Caffeoylquinic Acid from Brazilian arnica (Lychnophora ericoides) after Acute Retinal Ischemia	4
Pinellic Acid Isolated from Quercetin-rich Onions has a Peroxisome Proliferator-Activated Receptor-Alpha/Gamma (PPAR-α/γ) Transactivation Activity	4
Competitive CatSper Activators of Progesterone from Rhynchosia volubilis	4