OOIR: Observatory of International Research

Papers

(The TQCC of Planta Medica is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Rosmarinic Acid–Human Pharmacokinetics and Health Benefits	70
Challenges at the Time of COVID-19: Opportunities and Innovations in Antivirals from Nature	67
Anti-biofilm and Virulence Factor-Reducing Activities of Essential Oils and Oil Components as a Possible Option for Bacterial Infection Control	38
Verbena officinalis (Common Vervain) – A Review on the Investigations of This Medicinally Important Plant Species	35
Artemisia annua – Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications	29
Punica granatum Leaf Ethanolic Extract and Ellagic Acid as Inhibitors of Zika Virus Infection	29
Quality Control of Herbal Medicines: From Traditional Techniques to State-of-the-art Approaches	27
A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders	26
Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum	25
Medicinal Plants in the Treatment of Depression: Evidence from Preclinical Studies	23
α-Glucosidase Inhibitory Depsidones from the Lichen Parmotrema tsavoense	22
Antiviral and Virucidal Properties of Essential Oils and Isolated Compounds – A Scientific Approach	22
Cannabis sativa and Skin Health: Dissecting the Role of Phytocannabinoids	21
A Systematic Review on Secondary Metabolites of Paecilomyces Species: Chemical Diversity and Biological Activity	21
Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents	20
Pharmacokinetics and Safety of Mitragynine in Beagle Dogs	18
A Systematic Review of the Potential Effects of Nigella sativa on Rheumatoid Arthritis	18
Lichen Depsidones with Biological Interest	18
A Review of the Phytochemistry, Traditional Uses and Biological Activities of the Essential Oils of Genus Teucrium	18
Antiviral Potential of Spondias mombin L. Leaves Extract Against Herpes Simplex Virus Type-1 Replication Using In Vitro and In Silico Approaches	17
Phenolic-rich Pomegranate Peel Extract: In Vitro, Cellular, and In Vivo Activities for Skin Hyperpigmentation Treatment	16
Natural Products as a Source of Inspiration for Novel Inhibitors of Advanced Glycation Endproducts (AGEs) Formation	16
Isoliquiritigenin Nanosuspension Enhances Cytostatic Effects in A549 Lung Cancer Cells	15
Medicinal Plants for Insomnia Related to Anxiety: An Updated Review	15
Composition and Antibacterial Effect of Mint Flavorings in Candies and Food Supplements	14

Brown-Algae Polysaccharides as Active Constituents against Nonalcoholic Fatty Liver Disease	14
Volatile Antimicrobial Agents and In Vitro Methods for Evaluating Their Activity in the Vapour Phase: A Review	14
Enhanced Oral Bioavailability and Improved Biological Activities of a Quercetin/Resveratrol Combination Using a Liquid Self-Microemulsifying Drug Delivery System	14
Beta-Glucuronidase Inhibition by Constituents of Mulberry Bark	14
Biochanin A, the Most Potent of 16 Isoflavones, Induces Relaxation of the Coronary Artery Through the Calcium Channel and cGMP-dependent Pathway	14
Norway Spruce Balm: Phytochemical Composition and Ability to Enhance Re-epithelialization In Vitro	13
Wild Strawberry, Blackberry, and Blueberry Leaf Extracts Alleviate Starch-Induced Hyperglycemia in Prediabetic and Diabetic Mice	13
Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects	12
HPLC-UV, Metabarcoding and Genome Skims of Botanical Dietary Supplements: A Case Study in Echinacea	12
Ginkgo biloba and Its Constituent 6-hydroxykynurenic-acid as well as Its Proanthocyanidins Exert Neurorestorative Effects against Cerebral Ischemia	12
Antiviral Medicinal Plants of Veterinary Importance: A Literature Review	12
Cacao Bean Polyphenols Inhibit Cardiac Hypertrophy and Systolic Dysfunction in Pressure Overload-induced Heart Failure Model Mice	12
Investigation of Antiplasmodial Effects of Terpenoid Compounds Isolated from Myrrh	12
Essential Oils as a Potential Treatment Option for Pediculosis	12
Chemical Ecology in Insect-microbe Interactions in the Neotropics	11
Antinociceptive Activity of Asiaticoside in Mouse Models of Induced Nociception	11
Erianthridin Induces Non-small Cell Lung Cancer Cell Apoptosis through the Suppression of Extracellular Signal-regulated Kinase Activity	11
Chemical Characterization of Lavandula dentata Essential Oil Cultivated in Chile and Its Antibiofilm Effect against Candida albicans	10
ELISA for the Detection of the Prohibited Doping Agent Higenamine	10
In Vitro and In Vivo Metabolic Activation of Obacunone, A Bioactive and Potentially Hepatotoxic Constituent of Dictamni Cortex	10
Novel Insights into Pyrrolizidine Alkaloid Toxicity and Implications for Risk Assessment: Occurrence, Genotoxicity, Toxicokinetics, Risk Assessment–A Workshop Report	10
Regulatory Perspectives of Pyrrolizidine Alkaloid Contamination in Herbal Medicinal Products	10
Nanoencapsulation of Plant Volatile Organic Compounds to Improve Their Biological Activities	10
Chemical Constituents from Physalis Calyx seu Fructus and Their Inhibitory Effects against Oxidative Stress and Inflammatory Response	10
Identification and α-Glucosidase Inhibitory Activity of Meroterpenoids from Hericium erinaceus	9
Pressurized Natural Deep Eutectic Solvent Extraction of Galanthamine and Related Alkaloids from Narcissus pseudonarcissus	9
A Proposal Towards a Rational Classification of the Antimicrobial Activity of Acetone Tree Leaf Extracts in a Search for New Antimicrobials	9
A Novel Peptide Derived from Ginger Induces Apoptosis through the Modulation of p53, BAX, and BCL2 Expression in Leukemic Cell Lines	9
Characterization of Maca (Lepidium meyenii/Lepidium peruvianum) Using a Mass Spectral Fingerprinting, Metabolomic Analysis, and Genetic Sequencing Approach	9
Rosmarinic Acid Intravitreal Implants: A New Therapeutic Approach for Ocular Neovascularization	9
Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential	9
The Potential Application of Pentacyclic Triterpenoids in the Prevention and Treatment of Retinal Diseases	8
Phyllobilins – Bioactive Natural Products Derived from Chlorophyll – Plant Origins, Structures, Absorption Spectra, and Biomedical Properties	8
Kratom (Mitragyna speciosa) Validation: Quantitative Analysis of Indole and Oxindole Alkaloids Reveals Chemotypes of Plants and Products	8
Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways	8
Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery	8
Review of Studies on Phlomis and Eremostachys Species (Lamiaceae) with Emphasis on Iridoids, Phenylethanoid Glycosides, and Essential Oils	8
Berberine Regulates GPX4 to Inhibit Ferroptosis of Islet β Cells	8
Berberine Ameliorates Glucose Metabolism in Diabetic Rats through the alpha7 Nicotinic Acetylcholine Receptor-Related Cholinergic Anti-Inflammatory Pathway	8
Novel Piperidine and 3,4-dihydro-2H-pyrrole Alkaloids from Tilia platyphyllos and Tilia cordata Flowers	8
Cytotoxicity and Antiviral Activities of Haplophyllum tuberculatum Essential Oils, Pure Compounds, and Their Combinations against Coxsackievirus B3 and B4	8
Protection of Beta Boswellic Acid against Streptozotocin-induced Alzheimerʼs Model by Reduction of Tau Phosphorylation Level and Enhancement of Reelin Expression	8
Rhytidhyesters A – D, 4 New Chlorinated Cyclopentene Derivatives from the Endophytic Fungus Rhytidhysteron sp. BZM-9	8
Pyrrolizidine Alkaloid Contamination in Medicinal Plants: Regulatory Requirements and Their Impact on Production and Quality Control of Herbal Medicinal Products	8
New Pyrrolobenzoxazine Sesquiterpenoid Derivatives from the Fungus Talaromyces trachyspermus	8
Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea	7
Bulbine natalensis (currently Bulbine latifolia) and select bulbine knipholones modulate the activity of AhR, CYP1A2, CYP2B6, and P-gp	7
Antiprotozoal activities of Triterpenic Acids and Ester Derivatives Isolated from the Leaves of Vitellaria paradoxa	7
Characterization of Antibacterial Proanthocyanidins of Dalbergia monetaria, an Amazonian Medicinal Plant, by UHPLC-HRMS/MS	7
13C NMR Dereplication Using MixONat Software: A Practical Guide to Decipher Natural Products Mixtures	7

Bioaccessibility and Absorption of Flavonoid C-glycosides from Abrus mollis Using Simulated Digestion, Caco-2 Cell, and In Situ Single-pass Perfusion Models	7
Artocarpus lacucha Extract and Oxyresveratrol Inhibit Glucose Transporters in Human Intestinal Caco-2 Cells	7
Ethnoveterinary Remedies Used in Avian Complementary Medicine in Selected Communal Areas in Zimbabwe	7
Bioactive Properties of the Aqueous Extracts of Endophytic Fungi Associated with Scots Pine (Pinus sylvestris) Roots	7
Medicinal Plants in the Treatment of Depression. II: Evidence from Clinical Trials	7
Prospecting and Identifying Phyllanthus amarus Lignans with Antileishmanial and Antitrypanosomal Activity	7
Cardiovascular Effects Induced by Fruit Peels from Passiflora edulis in Hypertensive Rats and Fingerprint Analysis by HPLC-ESI-MSn spectrometry	7
Medicinal Plants for the Treatment of Mental Diseases in Pregnancy: An In Vitro Safety Assessment	7
Screening of Bufadienolides from Toad Venom Identifies Gammabufotalin as a Potential Anti-inflammatory Agent	7
Low Piperine Fractional Piper nigrum Extract Enhanced the Antitumor Immunity via Regulating the Th1/Th2/Treg Cell Subsets on NMU-Induced Tumorigenesis Rats	7
Sulfation of Quercitrin, Epicatechin and Rutin by Human Cytosolic Sulfotransferases (SULTs): Differential Effects of SULT Genetic Polymorphisms	7
The Role of Kinetics as Key Determinant in Toxicity of Pyrrolizidine Alkaloids and Their N-Oxides	6
Phloridzin Highly Accumulated in Malus rockii Rehder and Its Structure Revision and Hypolipidemic Activity	6
Total Flavonoids of Bidens pilosa Ameliorates Bone Destruction in Collagen-Induced Arthritis	6
Phytogenic Compounds for Enhancing Intestinal Barrier Function in Poultry–A Review	6
Molecular Networking Discloses the Chemical Diversity of Flavonoids and Selaginellins in Selaginella convoluta	6
Pharmacokinetic Properties of Moracin C in Mice	6
Identification and Quantification of Polymethoxylated Flavonoids in Different Citrus Species Using UPLC-QTOF-MS/MS and HPLC-DAD	6
A New Diterpene and Anti-inflammatory Sesquiterpene Lactones from Sigesbeckia orientalis	6
Achiote (Bixa orellana) Lipophilic Extract, Bixin, and δ-tocotrienol Effects on Lifespan and Stress Resistance in Caenorhabditis elegans	6
A Detailed View on the Proanthocyanidins in Ginkgo Extract EGb 761	6
Medical Devices Made of Substances: Possible Innovation and Opportunities for Complex Natural Products	6
Anticancer Potential of Compounds from the Brazilian Blue Amazon	6
The Potential of Biologically Active Brazilian Plant Species as a Strategy to Search for Molecular Models for Mosquito Control	6
Resveratrol Protects BEAS-2B Cells against Erastin-Induced Ferroptosis through the Nrf2/Keap1 Pathway	6
Vasorelaxing Activity of Stilbenoid and Phenanthrene Derivatives from Brasiliorchis porphyrostele: Involvement of Smooth Muscle CaV1.2 Channels	6
Coffee Leaves: An Upcoming Novel Food?	6
Inhibition of Proinflammatory Cytokine Release by Flavones and Flavanones from the Leaves of Dracaena steudneri Engl.	6
Folklore, Animal Self-Medication, and Phytotherapy–Something Old, Something New, Something Borrowed, Some Things True	6
Cytotoxic, Antioxidant, and Antidiabetic Activities versus UPLC-ESI-QTOF-MS Chemical-Profile Analysis of Ipomoea aquatica Fractions	6
In Vitro and In Silico Evaluation of ACE2 and LOX Inhibitory Activity of Origanum Essential Oils and Carvacrol	6
Protective Effects of Total Alkaloids from Menispermum dauricum against Airway Inflammation in Asthmatic Mice	6
Cytotoxic Agents in the Minor Alkaloid Groups of the Amaryllidaceae	6
cis-Aconitic Acid, a Constituent of Echinodorus grandiflorus Leaves, Inhibits Antigen-Induced Arthritis and Gout in Mice	5
Placental Passage of Protopine in an Ex Vivo Human Perfusion System	5
Cytochalasan Alkaloids as TRAIL Sensitizers from an Endophytic Fungus Chaetomium sp.	5
Accumulation of the Major Components from Polygoni Multiflori Radix in Liver and Kidney after Its Long-Term Oral Administrations in Rats	5
Herbal Products in Postsurgical Wound Healing – Incision, Excision and Dead Space Wound Models	5
Extract of the Aerial Part of Polygala tenuifolia Attenuates d-Galactose/NaNO2-induced Learning and Memory Impairment in Mice	5
In vitro and In Vivo Immunomodulatory Activity of Physalis angulata Concentrated Ethanolic Extract	5
Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes	5
Hydroalcoholic Extract of Myrcia bella Loaded into a Microemulsion System: A Study of Antifungal and Mutagenic Potential	5
Undescribed C-Glycosylflavones from Corn Silk and Potential Anti-inflammatory Activity Evaluation of Isolates	5
Optimization and Evaluation of Self-nanoemulsifying Drug Delivery System for Enhanced Bioavailability of Plumbagin	5
Withanolides from Withania somnifera Ameliorate Neutrophil Infiltration in Endotoxin-Induced Peritonitis by Regulating Oxidative Stress and Inflammatory Cytokines	5
Cornus sanguinea Fruits: a Source of Antioxidant and Antisenescence Compounds Acting on Aged Human Dermal and Gingival Fibroblasts	5
Natural Prenylated Xanthones as Potential Inhibitors of PI3k/Akt/mTOR Pathway in Triple Negative Breast Cancer Cells	5
Identification of TRPV1 Ion Channels Agonists of Tropaeolum tuberosum in Human Skin Keratinocytes	5
Network Pharmacological Screening of the Active Ingredients and Hypoglycemic Effect of Isodon rubescens in the Treatment of Diabetes	5
Acaricidal Activity of Artemisia nilagirica Leaves Against Rhipicephalus (Boophilus) annulatus Ticks	5
Beyond the Psychoactive Effects of Ayahuasca: Cultural and Pharmacological Relevance of Its Emetic and Purging Properties	5
Involvement of the Benzodiazepine Site in the Anticonvulsant Activity of Tapinanthus globiferus against Pentylenetetrazole-induced Seizures in Mice	5
Comparative Transcriptome Analysis Reveals Candidate Genes Involved in Isoquinoline Alkaloid Biosynthesis in Stephania tetrandra	5
Isolation and Characterization of Acetylcholinesterase Inhibitors from Piper longum and Binding Mode Predictions	5
Quantification of Silymarin in Silybi mariani fructus: Challenging the Analytical Performance of Benchtop vs. Handheld NIR Spectrometers on Whole Seeds	5