OOIR: Observatory of International Research

Papers

(The median citation count of Physiological Reviews is 24. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Neuropathic Pain: From Mechanisms to Treatment	687
Diversity and Biology of Cancer-Associated Fibroblasts	641
Pregnancy and COVID-19	431
Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation	403
Regulation and metabolic functions of mTORC1 and mTORC2	346
Brain mechanisms of insomnia: new perspectives on causes and consequences	233
Molecular physiology of bile acid signaling in health, disease, and aging	231
Fluid transport in the brain	231
Exercise under heat stress: thermoregulation, hydration, performance implications, and mitigation strategies	207
Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning	201
Developmental origins of metabolic diseases	201
Bone metastasis: mechanisms, therapies, and biomarkers	200
Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications	187
Cellular Circuits in the Brain and Their Modulation in Acute and Chronic Pain	186
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs	176
Mitochondrial calcium exchange in physiology and disease	170
Role ofO-linkedN-acetylglucosamine protein modification in cellular (patho)physiology	166
Sex determination, gonadal sex differentiation, and plasticity in vertebrate species	161
Mitochondria in health, disease, and aging	154
The complexity of Alzheimer’s disease: an evolving puzzle	144
Calcium-release channels: structure and function of IP₃ receptors and ryanodine receptors	118
The osteocyte as a signaling cell	118
Rho GTPase signaling in cancer progression and dissemination	118
Physiology and pathophysiology of human airway mucus	113
Human temperature regulation under heat stress in health, disease, and injury	113

Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior	112
Cardiac Mechano-Electric Coupling: Acute Effects of Mechanical Stimulation on Heart Rate and Rhythm	107
Mitochondrial quality control in health and in Parkinson’s disease	102
Carotid body chemoreceptors: physiology, pathology, and implications for health and disease	99
Glial Connexins and Pannexins in the Healthy and Diseased Brain	92
CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond	88
The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas	87
The enteric nervous system	86
Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training	80
ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum	80
Nongenomic Actions of Thyroid Hormone: The Integrin Component	78
Inflammation and thrombosis in COVID-19 pathophysiology: proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets	77
The physiological control of eating: signals, neurons, and networks	77
Neuronal Circuits in Barrel Cortex for Whisker Sensory Perception	74
G protein-coupled receptor-G protein interactions: a single-molecule perspective	66
Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology	66
RNA-binding proteins balance brain function in health and disease	65
Sodium channelopathies of skeletal muscle and brain	65
The physiological functions of human peroxisomes	65
Albumin uptake and processing by the proximal tubule: physiological, pathological, and therapeutic implications	64
Phosphate Transport in Epithelial and Nonepithelial Tissue	63
Vascular mechanotransduction	63
Optophysiology: Illuminating cell physiology with optogenetics	63
How development sculpts hippocampal circuits and function	59
Do hippocampal pyramidal cells respond to nonspatial stimuli?	59
Physiological roles of mammalian transmembrane adenylyl cyclase isoforms	59
Lymphatic vessels in cancer	59
Mechanisms and physiological implications of cooperative gating of clustered ion channels	59
Trained immunity: adaptation within innate immune mechanisms	56
Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum	56
Salivary gland function, development, and regeneration	55
Moving immune therapy forward targeting tme	55
Physiology of sedentary behavior	55
Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions	54
The evolution of regulated cell death pathways in animals and their evasion by pathogens	54
Neutrophil extracellular traps in the pathology of cancer and other inflammatory diseases	53
The superoxide radical switch in the biology of nitric oxide and peroxynitrite	51
Principles of odor coding in vertebrates and artificial chemosensory systems	49
Telomere-mediated lung disease	49
What’s the buzz? The neuroscience and the treatment of tinnitus	48
Multisystem physiological perspective of human frailty and its modulation by physical activity	46
Microcircuits for spatial coding in the medial entorhinal cortex	45
The molecular athlete: exercise physiology from mechanisms to medals	45
The science and engineering behind sensitized brain-controlled bionic hands	41
Cellular senescence and cardiovascular diseases: moving to the “heart” of the problem	41
The FGF/FGFR system in the physiopathology of the prostate gland	40
Energy metabolism design of the striated muscle cell	39
Development of antifibrotic therapy for stricturing Crohn’s disease: lessons from randomized trials in other fibrotic diseases	39
Determinants, maintenance, and function of organellar pH	38
CD38 in the age of COVID-19: a medical perspective	36

Sympathetic and sensory-motor nerves in peripheral small arteries	36
Folding brains: from development to disease modeling	35
The role of junctophilin proteins in cellular function	34
Clonal hematopoiesis, somatic mosaicism, and age-associated disease	34
Development and physiological functions of the lymphatic system: insights from human genetic studies of primary lymphedema	33
Circadian clocks of the kidney: function, mechanism, and regulation	33
Protease-activated receptors in health and disease	32
Making a good egg: human oocyte health, aging, and in vitro development	32
The choroid plexus: a missing link in our understanding of brain development and function	32
Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology	30
Ion channels and channelopathies in glomeruli	30
Sperm bauplan and function and underlying processes of sperm formation and selection	30
Lipodystrophy: A paradigm for understanding the consequences of "overloading" adipose tissue	29
Physiology of the tongue with emphasis on taste transduction	26
Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease	25
Synaptic memory and CaMKII	25
Complex physiology and clinical implications of time-restricted eating	24
Genome-wide association studies of cardiovascular disease	24
Contribution of adaptive immunity to human COPD and experimental models of emphysema	24
Physiology of intracellular calcium buffering	24