OOIR: Observatory of International Research

Papers

(The median citation count of Physiological Reviews is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca²⁺ signaling	535
Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries	461
SIRT7: the seventh key to unlocking the mystery of aging	320
Making a good egg: human oocyte health, aging, and in vitro development	304
Implications of the NADase CD38 in COVID pathophysiology	287
A comprehensive review of the neuroscience of ingestion: the physiological control of eating: signals, neurons, and networks	282
Systematic reviews for basic scientists: a different beast	275
Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes	259
Regulation and metabolic functions of mTORC1 and mTORC2	254
Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation	236
Sodium channelopathies of skeletal muscle and brain	229
Sex differences in blood pressure regulation and hypertension: renal, hemodynamic, and hormonal mechanisms	210
Contribution of adaptive immunity to human COPD and experimental models of emphysema	201
Rho GTPase signaling in cancer progression and dissemination	185
The complexity of Alzheimer’s disease: an evolving puzzle	161
Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion	160
Understanding COVID-19 susceptibility and presentation based on its underlying physiology	160
Brain mechanisms of insomnia: new perspectives on causes and consequences	157
Mitochondrial calcium exchange in physiology and disease	151
A primer on obesity-related cardiomyopathy	150
NETosis creates a link between diabetes and Long COVID	145
Complex physiology and clinical implications of time-restricted eating	143
Calcium-release channels: structure and function of IP₃ receptors and ryanodine receptors	133
The physiological control of eating: signals, neurons, and networks	127
The enteric nervous system	116

Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior	115
Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives	111
Genome-wide association studies of cardiovascular disease	107
The molecular athlete: exercise physiology from mechanisms to medals	106
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs	106
How development sculpts hippocampal circuits and function	95
Redox signaling in the pancreas in health and disease	92
Physiological roles of mammalian transmembrane adenylyl cyclase isoforms	91
Determinants, maintenance, and function of organellar pH	91
Bone metastasis: mechanisms, therapies, and biomarkers	89
The anterior chamber of the eye technology and its anatomical, optical, and immunological bases	87
Is Notch1 a neglected vascular mechanosensor?	87
The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes	85
Bioenergetics: the evolutionary basis of progressive kidney disease	85
Principles of odor coding in vertebrates and artificial chemosensory systems	83
G protein-coupled receptor-G protein interactions: a single-molecule perspective	81
In celebration of the 100th anniversary of Physiological Reviews	80
Evolutionarily conserved transcription factors as regulators of longevity and targets for geroprotection	78
Community-acquired bacterial coinfections and COVID-19	77
Development of antifibrotic therapy for stricturing Crohn’s disease: lessons from randomized trials in other fibrotic diseases	76
The elusive cephalic phase insulin response: triggers, mechanisms, and functions	76
Transforming the concept of connectivity: unveiling tunneling nanotube biology, and their roles in brain development and neurodegeneration.	75
Wonder of wonders, miracle of miracles: the unprecedented speed of COVID-19 science	75
Fluid transport in the brain	74
Nanodomain cAMP signaling in cardiac pathophysiology: potential for developing targeted therapeutic interventions	71
Navigating the multifaceted intricacies of the Na⁺-Cl⁻ cotransporter, a highly regulated key effector in the control of hydromineral homeostasis	70
Pathophysiology of syncope: current concepts and their development	69
Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology	69
Ca²⁺ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract	64
Mechanisms of SARS-CoV-2-associated anosmia	60
Exercise under heat stress: thermoregulation, hydration, performance implications, and mitigation strategies	58
Trained immunity: adaptation within innate immune mechanisms	57
The physiological functions of human peroxisomes	57
Modulating vertebrate physiology by genomic fine-tuning of GPCR functions	55
CD38 in the age of COVID-19: a medical perspective	53
Cannabinoid treatments in epilepsy and seizure disorders	52
Developmental origins of metabolic diseases	51
Altered islet prohormone processing: a cause or consequence of diabetes?	51
Membrane adhesion junctions regulate airway smooth muscle phenotype and function	50
Development and physiological functions of the lymphatic system: insights from human genetic studies of primary lymphedema	49
Phosphodiesterase in heart and vessels: from physiology to diseases	49
Sperm bauplan and function and underlying processes of sperm formation and selection	48
The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas	47
The neurobiology of parenting and infant-evoked aggression	47
Protease-activated receptors in health and disease	47
Salivary gland function, development, and regeneration	44
Human temperature regulation under heat stress in health, disease, and injury	44
Multiscale structure and function of the aortic valve apparatus	42
Mechanisms of myosin II force generation: insights from novel experimental techniques and approaches	40
Sympathetic circuits regulating hepatic glucose metabolism: where we stand	40

Uterine Fibroids	40
Mesenchymal condensation in tooth development and regeneration: a focus on translational aspects of organogenesis	39
Hepatic glucagon action: beyond glucose mobilization	36
Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology	36
Vascular mechanotransduction	36
The osteocyte as a signaling cell	36
Windows into stress: a glimpse at emerging roles for CRH^PVN neurons	35
The multiple roles of salt-inducible kinases in regulating physiology	34
Physiological basis for xenotransplantation from genetically modified pigs to humans	34
Lymphatic vessels in cancer	33
Examining the shared etiology of psychopathology with genome-wide association studies	33
Mechanisms and physiological implications of cooperative gating of clustered ion channels	32
Energy metabolism design of the striated muscle cell	30
Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training	30