OOIR: Observatory of International Research

Papers

(The median citation count of Physiological Reviews is 28. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries	609
SIRT7: the seventh key to unlocking the mystery of aging	382
Making a good egg: human oocyte health, aging, and in vitro development	350
Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca²⁺ signaling	339
Implications of the NADase CD38 in COVID pathophysiology	335
A comprehensive review of the neuroscience of ingestion: the physiological control of eating: signals, neurons, and networks	273
Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes	261
Systematic reviews for basic scientists: a different beast	241
Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation	205
Metabolic adaptations in cancer progression	201
The physiopathology of brain-derived neurotrophic factor	201
Sex differences in blood pressure regulation and hypertension: renal, hemodynamic, and hormonal mechanisms	184
Sodium channelopathies of skeletal muscle and brain	175
Rho GTPase signaling in cancer progression and dissemination	172
Contribution of adaptive immunity to human COPD and experimental models of emphysema	171
Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion	168
Immunotherapy for atherosclerosis	160
Understanding COVID-19 susceptibility and presentation based on its underlying physiology	141
Mitochondrial calcium exchange in physiology and disease	135
NETosis creates a link between diabetes and Long COVID	128
A primer on obesity-related cardiomyopathy	122
Molecular dissection of the role of ACE2 in glucose homeostasis	122
The enteric nervous system	117
The physiological control of eating: signals, neurons, and networks	116
Calcium-release channels: structure and function of IP₃ receptors and ryanodine receptors	116

Complex physiology and clinical implications of time-restricted eating	115
Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives	112
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs	111
Genome-wide association studies of cardiovascular disease	108
Angiocrine and Pericrine Signaling: How Endothelial Cells and Pericytes Drive Cancer Progression and Therapy Resistance	105
Determinants, maintenance, and function of organellar pH	101
How development sculpts hippocampal circuits and function	98
The molecular athlete: exercise physiology from mechanisms to medals	98
Physiological roles of mammalian transmembrane adenylyl cyclase isoforms	96
Redox signaling in the pancreas in health and disease	94
Bioenergetics: the evolutionary basis of progressive kidney disease	93
The anterior chamber of the eye technology and its anatomical, optical, and immunological bases	93
The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes	84
Is Notch1 a neglected vascular mechanosensor?	84
Principles of odor coding in vertebrates and artificial chemosensory systems	83
NADPH oxidases: redox regulation of cell homeostasis and disease	82
In celebration of the 100th anniversary of Physiological Reviews	78
Transforming the concept of connectivity: unveiling tunneling nanotube biology and their roles in brain development and neurodegeneration	77
Wonder of wonders, miracle of miracles: the unprecedented speed of COVID-19 science	76
Community-acquired bacterial coinfections and COVID-19	74
Development of antifibrotic therapy for stricturing Crohn’s disease: lessons from randomized trials in other fibrotic diseases	72
Physiologic mechanisms underlying polycystic kidney disease	72
The elusive cephalic phase insulin response: triggers, mechanisms, and functions	69
Nanodomain cAMP signaling in cardiac pathophysiology: potential for developing targeted therapeutic interventions	66
Fluid transport in the brain	64
Evolutionarily conserved transcription factors as regulators of longevity and targets for geroprotection	64
Navigating the multifaceted intricacies of the Na⁺-Cl⁻ cotransporter, a highly regulated key effector in the control of hydromineral homeostasis	63
Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology	62
Frontiers in the physiology of male pattern androgenetic alopecia: Beyond the androgen horizon	61
Pathophysiology of syncope: current concepts and their development	60
Ca²⁺ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract	60
Mechanisms of SARS-CoV-2-associated anosmia	58
The physiological functions of human peroxisomes	56
Trained immunity: adaptation within innate immune mechanisms	55
Exercise under heat stress: thermoregulation, hydration, performance implications, and mitigation strategies	53
Modulating vertebrate physiology by genomic fine-tuning of GPCR functions	53
Biomarkers of aging: from molecules and surrogates to physiology and function	52
Membrane adhesion junctions regulate airway smooth muscle phenotype and function	50
CD38 in the age of COVID-19: a medical perspective	50
Cannabinoid treatments in epilepsy and seizure disorders	50
Altered islet prohormone processing: a cause or consequence of diabetes?	50
Sperm bauplan and function and underlying processes of sperm formation and selection	48
Development and physiological functions of the lymphatic system: insights from human genetic studies of primary lymphedema	47
Phosphodiesterase in heart and vessels: from physiology to diseases	46
The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas	46
Protease-activated receptors in health and disease	45
Human temperature regulation under heat stress in health, disease, and injury	44
The neurobiology of parenting and infant-evoked aggression	44
Multiscale structure and function of the aortic valve apparatus	44
Salivary gland function, development, and regeneration	44

Mechanisms of myosin II force generation: insights from novel experimental techniques and approaches	43
Extracellular vesicles and the lung: from disease pathogenesis to biomarkers and treatments	43
Sympathetic circuits regulating hepatic glucose metabolism: where we stand	41
Hepatic glucagon action: beyond glucose mobilization	41
Mesenchymal condensation in tooth development and regeneration: a focus on translational aspects of organogenesis	40
The osteocyte as a signaling cell	39
Vascular mechanotransduction	39
Lymphatic vessels in cancer	37
Windows into stress: a glimpse at emerging roles for CRH^PVN neurons	35
Examining the shared etiology of psychopathology with genome-wide association studies	34
Physiological basis for xenotransplantation from genetically modified pigs to humans	33
Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology	31
The multiple roles of salt-inducible kinases in regulating physiology	31
Mechanisms and physiological implications of cooperative gating of clustered ion channels	30
Energy metabolism design of the striated muscle cell	30
Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training	29
Corrigendum for Eisner et al., volume 103, 2023, p. 2767–2845	29
A comprehensive view of muscle glucose uptake: regulation by insulin, contractile activity, and exercise	28
Acid-sensing ion channels: structure, function, pharmacology and clinical significance	28
Neuropathological links between T2DM and LOAD: systematic review and meta-analysis	28