OOIR: Observatory of International Research

Papers

(The median citation count of Physiological Reviews is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Do hippocampal pyramidal cells respond to nonspatial stimuli?	452
Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries	392
Energy metabolism design of the striated muscle cell	249
Altitude physiology then (1921) and now (2021): Meat on the bones	247
Recent insights into channelopathies	245
Degenerate neuronal and circuit mechanisms important for generating rhythmic motor patterns	238
Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives	223
Folding brains: from development to disease modeling	222
The evolution of regulated cell death pathways in animals and their evasion by pathogens	214
SIRT7: the seventh key to unlocking the mystery of aging	205
Heterogeneity of glutamatergic synapses: cellular mechanisms and network consequences	199
Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca²⁺ signaling	190
Climate change impacts on respiratory health: exposure, vulnerability, and risk	189
Ceramides are fuel gauges on the drive to cardiometabolic disease	182
Modulating vertebrate physiology by genomic fine-tuning of GPCR functions	172
The choroid plexus: a missing link in our understanding of brain development and function	171
Mitochondria in health, disease, and aging	132
Making a good egg: human oocyte health, aging, and in vitro development	130
Genome-wide association studies of cardiovascular disease	118
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs	118
Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training	118
Mechanisms and physiological implications of cooperative gating of clustered ion channels	118
Role ofO-linkedN-acetylglucosamine protein modification in cellular (patho)physiology	113
The FGF/FGFR system in the physiopathology of the prostate gland	110
Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior	109

Mammalian copper homeostasis: physiological roles and molecular mechanisms	102
Understanding coenzyme Q	90
Multisystem physiological perspective of human frailty and its modulation by physical activity	87
Moving immune therapy forward targeting tme	81
Developmental origins of metabolic diseases	80
Synaptic memory and CaMKII	77
Evolution of the diagnostic value of “the sugar of the blood”: hitting the sweet spot to identify alterations in glucose dynamics	77
Altered islet prohormone processing: a cause or consequence of diabetes?	74
The TRP Channels Serving as Chemical-to-Electrical Signal Converter	74
Psycho-physiological foundations of human physical activity behavior and motivation: Theories, systems, mechanisms, evolution, and genetics	69
Cannabinoid treatments in epilepsy and seizure disorders	68
How development sculpts hippocampal circuits and function	67
Leveraging physiology and artificial intelligence to deliver advancements in health care	66
Implications of the NADase CD38 in COVID pathophysiology	65
The role of globins in cardiovascular physiology	65
Lung antimicrobial proteins and peptides: from host defense to therapeutic strategies	64
CD38 in the age of COVID-19: a medical perspective	61
Determinants, maintenance, and function of organellar pH	60
The microbiome: an integral player in immune homeostasis and inflammation in the respiratory tract	60
The ion channels of endomembranes	59
The role of junctophilin proteins in cellular function	59
Bone metastasis: mechanisms, therapies, and biomarkers	59
Physiological roles of mammalian transmembrane adenylyl cyclase isoforms	59
Mitochondrial quality control in health and in Parkinson’s disease	59
Circadian clocks of the kidney: function, mechanism, and regulation	56
The molecular athlete: exercise physiology from mechanisms to medals	55
CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease	55
Phosphodiesterase in heart and vessels: from physiology to diseases	53
Corrigendum for Eisner et al., volume 103, 2023, p. 2767–2845	53
A comprehensive review of the neuroscience of ingestion: the physiological control of eating: signals, neurons, and networks	53
Neurobiology and systems biology of stress resilience	51
Is Notch1 a neglected vascular mechanosensor?	49
Timing and cause of olfactory deciliation in COVID-19	46
Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes	46
The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes	45
The superoxide radical switch in the biology of nitric oxide and peroxynitrite	45
The anterior chamber of the eye technology and its anatomical, optical, and immunological bases	43
Membrane adhesion junctions regulate airway smooth muscle phenotype and function	43
Bioenergetics: the evolutionary basis of progressive kidney disease	41
The ebb and flow of cardiac lymphatics: a tidal wave of new discoveries	40
Regulation and metabolic functions of mTORC1 and mTORC2	39
Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation	38
Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum	37
The human periconceptional maternal-embryonic space in health and disease	36
Systematic reviews for basic scientists: a different beast	36
Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation	36
The placenta: epigenetic insights into trophoblast developmental models of a generation-bridging organ with long-lasting impact on lifelong health	35
Protease-activated receptors in health and disease	35
The science and engineering behind sensitized brain-controlled bionic hands	35
The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas	34

ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum	33
Cellular senescence and cardiovascular diseases: moving to the “heart” of the problem	32
A systematic review of the biological mediators of fat taste and smell	32
Obstructive nephropathy and molecular pathophysiology of renal interstitial fibrosis	30
Physiology of the tongue with emphasis on taste transduction	29
CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond	28
Development and physiological functions of the lymphatic system: insights from human genetic studies of primary lymphedema	27
Sex determination, gonadal sex differentiation, and plasticity in vertebrate species	25
Contribution of adaptive immunity to human COPD and experimental models of emphysema	24
The hormonal control of parturition	24
Sperm bauplan and function and underlying processes of sperm formation and selection	24
Pregnancy and the SARS-CoV-2 pandemic	23
Lung endothelium, tau, and amyloids in health and disease	22
Sex differences in blood pressure regulation and hypertension: renal, hemodynamic, and hormonal mechanisms	22
Eukaryotic cell size regulation and its implications for cellular function and dysfunction	22
The role of quality metrics in the evolution of AI in health care and implications for generative AI	22
Albumin uptake and processing by the proximal tubule: physiological, pathological, and therapeutic implications	22
Rho GTPase signaling in cancer progression and dissemination	22
Motor Control on the Move - from Insights in Insects to General Mechanisms	22