OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacological Reviews is 24. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Seventy-Five Years of Interactions: The Department of Physiology and Pharmacology at Karolinska Institutet and Pharmacological Reviews	285
Innovative therapeutics for renoprotection: Where we are	221
The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes	208
Review of Natural Language Processing in Pharmacology	171
The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics	144
Reimagining pharmacology education	135
The endocannabinoidomes: Pharmacological redundancy and promiscuity, and multi-kingdom variety of sources and molecular targets	133
Table of Contents	131
Table of Contents	129
Therapeutic advantage of combinatorial chimeric antigen receptor T cell and chemotherapies	123
Carbonic anhydrase inhibitors: “Old” drugs with new potential in unexpected areas	121
Metal-based antibody, nanobody, and peptide conjugates: Potential for breast cancer therapy	112
Mitochondrial metabolism as a pharmacological target for cancer therapeutics	110
Table of Contents	96
Pharmaceutical perspectives on oligonucleotide therapeutics and delivery systems	90
Optical Approaches for Investigating Neuromodulation and G Protein–Coupled Receptor Signaling	88
Targeting of kinases to treat neurodegenerative diseases	88
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023	75
Innovation in cancer pharmacotherapy through integrative consideration of germline and tumor genomes	73
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins	72
Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer	72
Pharmacology and therapeutics of bile acid synthesis and modification enzymes in metabolic diseases	71
The Skeletal Connectome: From Molecular Circuitry to Systemic Network Medicine	71
Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications	69
Table of Contents	69

Therapeutic Potential of Targeting Prokineticin Receptors in Diseases	68
G Protein-Coupled Receptor Pharmacology—Insights from Mass Spectrometry	64
miR-155 aberrant expression impairs tumor rejection because of its targeting of ICOSL and multiple pathways implicated in the antitumor response	64
Asthma therapeutics: Past, present, and future	64
The Hippo pathway: Organ size control and beyond	62
Corrigendum to “International Union of Basic and Clinical Pharmacology. CXIX. Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes” [Pharmacologic	60
Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism	60
Nonhormonal Male Contraceptive Development—Strategies for Progress	56
Sulfotransferase 2B1b, Sterol Sulfonation, and Disease	56
Neurobiology of the incubation of drug craving: An update	55
From neuroimmune circuits to targeted therapy of chronic pruritus	55
Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood	54
Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy	53
Kv7 channels as pharmacological targets for CNS diseases	49
Editorial Board	47
Dopamine, Immunity, and Disease	47
Disulfidptosis: A novel cell death mechanism with pathological significance and therapeutic potential in diseases	47
Pharmacological Reviews’ 75th Year Anniversary: Past and Future—Editorial	45
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications	43
Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks	41
Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting	39
International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors	38
Animal Behavior in Psychedelic Research	37
Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming	37
Conotoxins Targeting Voltage-Gated Sodium Ion Channels	37
Vitamin D and its analogs in immune system regulation	34
Table of Contents	33
Pharmacological strategies to bridge the gap between cancer and cardiovascular therapeutics	31
Harnessing multiomics technologies and machine learning for advancing personalized theranostic approaches in atherosclerosis	29
Erratum to “Advances and challenges in experimental models of posttraumatic epilepsy for therapeutic interventions” [Pharmacological Reviews 77 (2025) 100080]	29
The Development of Cannabinoids as Therapeutic Agents in the United States	28
International Union of Basic and Clinical Pharmacology. CXVIII. Update on the nomenclature for atypical chemokine receptors, including ACKR5	28
Potassium Channels in Parkinson’s Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment	27
Table of Contents	26
Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity	26
Drugging dancing protein clouds: A close look at disorder-based drug design	26
Modeling lung transporters and their influence on inhaled drug disposition	26
Epithelial cells in chronic obstructive pulmonary disease exacerbations: Targets for lung repair	26
Adrenoceptor Desensitization: Current Understanding of Mechanisms	25
Table of Contents	25
Development of small molecule inhibitors of hypoxia-inducible factors for cancer therapy	24
The complement system: Biology, pathology, and therapeutic interventions	24
Carbon dots for drug delivery: Insights into their potential in nanopharmacology	24