OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacological Reviews is 24. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Seventy-Five Years of Interactions: The Department of Physiology and Pharmacology at Karolinska Institutet and Pharmacological Reviews	362
Innovative therapeutics for renoprotection: Where we are	354
Neurobiological Mechanisms of Nicotine Reward and Aversion	221
The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes	155
The Nitrogen Mustards	142
The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics	132
Review of Natural Language Processing in Pharmacology	129
Therapeutic advantage of combinatorial chimeric antigen receptor T cell and chemotherapies	128
Table of Contents	126
Table of Contents	119
The endocannabinoidomes: Pharmacological redundancy and promiscuity, and multi-kingdom variety of sources and molecular targets	108
Metal-based antibody, nanobody, and peptide conjugates: Potential for breast cancer therapy	100
Carbonic anhydrase inhibitors: “Old” drugs with new potential in unexpected areas	97
Table of Contents	95
Pharmaceutical perspectives on oligonucleotide therapeutics and delivery systems	91
Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer	86
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023	86
Innovation in cancer pharmacotherapy through integrative consideration of germline and tumor genomes	84
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins	84
Optical Approaches for Investigating Neuromodulation and G Protein–Coupled Receptor Signaling	84
Table of Contents	83
Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review	83
G Protein-Coupled Receptor Pharmacology—Insights from Mass Spectrometry	77
Therapeutic Potential of Targeting Prokineticin Receptors in Diseases	67
Asthma therapeutics: Past, present, and future	64

Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications	63
miR-155 aberrant expression impairs tumor rejection because of its targeting of ICOSL and multiple pathways implicated in the antitumor response	62
Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response	60
The Hippo pathway: Organ size control and beyond	58
Therapeutics in the Pipeline Targeting α-Synuclein for Parkinson's Disease	57
Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism	55
Nonhormonal Male Contraceptive Development—Strategies for Progress	52
Corrigendum to “International Union of Basic and Clinical Pharmacology. CXIX. Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes” [Pharmacologic	52
Sulfotransferase 2B1b, Sterol Sulfonation, and Disease	51
Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy	48
Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood	47
Neurobiology of the incubation of drug craving: An update	46
Dopamine, Immunity, and Disease	45
Editorial Board	45
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications	44
Pharmacological Reviews’ 75th Year Anniversary: Past and Future—Editorial	43
Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease	42
Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions	38
Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks	38
Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting	37
Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming	35
Vitamin D and its analogs in immune system regulation	34
Conotoxins Targeting Voltage-Gated Sodium Ion Channels	33
Animal Behavior in Psychedelic Research	33
Pharmacological strategies to bridge the gap between cancer and cardiovascular therapeutics	32
Table of Contents	32
Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity	31
Immunology and Technology of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines	31
Erratum to “Advances and challenges in experimental models of posttraumatic epilepsy for therapeutic interventions” [Pharmacological Reviews 77 (2025) 100080]	30
International Union of Basic and Clinical Pharmacology. CXVIII. Update on the nomenclature for atypical chemokine receptors, including ACKR5	30
Potassium Channels in Parkinson’s Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment	30
Harnessing multiomics technologies and machine learning for advancing personalized theranostic approaches in atherosclerosis	29
The Development of Cannabinoids as Therapeutic Agents in the United States	28
Table of Contents	28
Drugging dancing protein clouds: A close look at disorder-based drug design	28
Table of Contents	27
Synergistic combinations of antimicrobial peptides and conventional antibiotics: A strategy to delay resistance emergence in World Health Organization priority bacteria	27
Carbon dots for drug delivery: insights into their potential in nanopharmacology	26
Modeling lung transporters and their influence on inhaled drug disposition	25
Development of small molecule inhibitors of hypoxia-inducible factors for cancer therapy	24
The complement system: Biology, pathology, and therapeutic interventions	24
Anticoagulants: From chance discovery to structure-based design	24