OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacological Reviews is 24. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Innovative therapeutics for renoprotection: Where we are	433
Seventy-Five Years of Interactions: The Department of Physiology and Pharmacology at Karolinska Institutet and Pharmacological Reviews	426
The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes	259
The Nitrogen Mustards	205
Reimagining pharmacology education	187
The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics	161
Review of Natural Language Processing in Pharmacology	152
Therapeutic advantage of combinatorial chimeric antigen receptor T cell and chemotherapies	138
Table of Contents	124
Metal-based antibody, nanobody, and peptide conjugates: Potential for breast cancer therapy	123
Table of Contents	123
Carbonic anhydrase inhibitors: “Old” drugs with new potential in unexpected areas	115
The endocannabinoidomes: Pharmacological redundancy and promiscuity, and multi-kingdom variety of sources and molecular targets	110
Table of Contents	109
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023	102
Pharmaceutical perspectives on oligonucleotide therapeutics and delivery systems	102
Pharmacology and therapeutics of bile acid synthesis and modification enzymes in metabolic diseases	90
Optical Approaches for Investigating Neuromodulation and G Protein–Coupled Receptor Signaling	84
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins	79
Innovation in cancer pharmacotherapy through integrative consideration of germline and tumor genomes	79
Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer	73
Targeting of kinases to treat neurodegenerative diseases	70
Table of Contents	69
G Protein-Coupled Receptor Pharmacology—Insights from Mass Spectrometry	67
Asthma therapeutics: Past, present, and future	66

miR-155 aberrant expression impairs tumor rejection because of its targeting of ICOSL and multiple pathways implicated in the antitumor response	61
Therapeutic Potential of Targeting Prokineticin Receptors in Diseases	60
Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism	60
The Hippo pathway: Organ size control and beyond	60
Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response	60
Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications	57
Sulfotransferase 2B1b, Sterol Sulfonation, and Disease	56
Corrigendum to “International Union of Basic and Clinical Pharmacology. CXIX. Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes” [Pharmacologic	56
From neuroimmune circuits to targeted therapy of chronic pruritus	54
Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood	52
Nonhormonal Male Contraceptive Development—Strategies for Progress	52
Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy	51
Disulfidptosis: A novel cell death mechanism with pathological significance and therapeutic potential in diseases	51
Neurobiology of the incubation of drug craving: An update	51
Dopamine, Immunity, and Disease	49
Pharmacological Reviews’ 75th Year Anniversary: Past and Future—Editorial	49
Editorial Board	49
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications	47
Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming	47
International Union of Basic and Clinical Pharmacology xxx: Applying an objective evaluation to the status of Class A orphan G protein-coupled receptors	44
Animal Behavior in Psychedelic Research	44
Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks	43
Conotoxins Targeting Voltage-Gated Sodium Ion Channels	42
Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting	40
Vitamin D and its analogs in immune system regulation	38
Table of Contents	37
Pharmacological strategies to bridge the gap between cancer and cardiovascular therapeutics	37
Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity	34
Erratum to “Advances and challenges in experimental models of posttraumatic epilepsy for therapeutic interventions” [Pharmacological Reviews 77 (2025) 100080]	34
The Development of Cannabinoids as Therapeutic Agents in the United States	34
Harnessing multiomics technologies and machine learning for advancing personalized theranostic approaches in atherosclerosis	33
Potassium Channels in Parkinson’s Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment	32
International Union of Basic and Clinical Pharmacology. CXVIII. Update on the nomenclature for atypical chemokine receptors, including ACKR5	31
Table of Contents	30
Drugging dancing protein clouds: A close look at disorder-based drug design	30
Epithelial cells in chronic obstructive pulmonary disease exacerbations: Targets for lung repair	30
Modeling lung transporters and their influence on inhaled drug disposition	28
Carbon dots for drug delivery: Insights into their potential in nanopharmacology	28
Table of Contents	27
Synergistic combinations of antimicrobial peptides and conventional antibiotics: A strategy to delay resistance emergence in World Health Organization priority bacteria	27
Anticoagulants: From chance discovery to structure-based design	26
Development of small molecule inhibitors of hypoxia-inducible factors for cancer therapy	26
The complement system: Biology, pathology, and therapeutic interventions	24
From bone sentinel to immune savant: Vitamin D and its receptor’s pharmacology	24
Adrenoceptor Desensitization: Current Understanding of Mechanisms	24