OOIR: Observatory of International Research

Papers

(The median citation count of Pharmacological Reviews is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Seventy-Five Years of Interactions: The Department of Physiology and Pharmacology at Karolinska Institutet and Pharmacological Reviews	667
Table of Contents	446
Animal Models of Drug Relapse and Craving after Voluntary Abstinence: A Review	268
INNOVATIVE THERAPEUTICS FOR RENOPROTECTION: WHERE WE ARE	232
Neurobiological Mechanisms of Nicotine Reward and Aversion	151
The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes	118
The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics	105
L-Type Calcium Channel Blockers: A Potential Novel Therapeutic Approach to Drug Dependence	101
The Nitrogen Mustards	97
Editorial Board	93
Review of Natural Language Processing in Pharmacology	90
Therapeutic advantage of combinatorial chimeric antigen receptor T cell and chemotherapies	89
Table of Contents	88
Table of Contents	87
Carbonic anhydrase inhibitors: “Old” drugs with new potential in unexpected areas	86
Table of Contents	81
Optical Approaches for Investigating Neuromodulation and G Protein–Coupled Receptor Signaling	80
Innovation in cancer pharmacotherapy through integrative consideration of germline and tumor genomes	76
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins	74
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023	72
Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review	70
Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer	63
The Hippo pathway: Organ size control and beyond	62
Table of Contents	61
Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response	59

G Protein-Coupled Receptor Pharmacology—Insights from Mass Spectrometry	59
Asthma Therapeutics: Past, Present, and Future	59
Therapeutic Potential of Targeting Prokineticin Receptors in Diseases	59
Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism	56
Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications	55
Therapeutics in the Pipeline Targeting α-Synuclein for Parkinson's Disease	53
Nonhormonal Male Contraceptive Development—Strategies for Progress	52
Sulfotransferase 2B1b, Sterol Sulfonation, and Disease	51
Structure-Based Virtual Screening for Ligands of G Protein–Coupled Receptors: What Can Molecular Docking Do for You?	47
Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood	47
Corrigendum to “International Union of Basic and Clinical Pharmacology. CXIX. Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes” [Pharmacologic	46
Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy	44
Neurobiology of the incubation of drug craving: An update	44
Dopamine, Immunity, and Disease	42
Editorial Board	41
Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease	40
Analgesic Potential of Terpenes Derived from Cannabis sativa	39
Pharmacological Reviews’ 75th Year Anniversary: Past and Future—Editorial	39
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications	39
Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks	37
Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting	36
Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions	35
Conotoxins Targeting Voltage-Gated Sodium Ion Channels	34
Vitamin D and its analogs in immune system regulation	33
Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming	33
Animal Behavior in Psychedelic Research	32
Immunology and Technology of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines	32
The Development of Cannabinoids as Therapeutic Agents in the United States	30
Pharmacological strategies to bridge the gap between cancer and cardiovascular therapeutics	29
Table of Contents	28
Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity	26
Editorial Board	26
International Union of Basic and Clinical Pharmacology. CXVIII. Update on the nomenclature for atypical chemokine receptors, including ACKR5	24
Potassium Channels in Parkinson’s Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment	23
Drugging dancing protein clouds: A close look at disorder-based drug design	23
Table of Contents	22
Table of Contents	20
α6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials	20
Adrenoceptor Desensitization: Current Understanding of Mechanisms	19
Anticoagulants: From chance discovery to structure-based design	19
Novel and Emerging Treatments to Target Pathophysiological Mechanisms in Various Phenotypes of Multiple Sclerosis	18
From bone sentinel to immune savant: Vitamin D and its receptor’s pharmacology	18
Drug-Drug Interactions and Synergy: From Pharmacological Models to Clinical Application	17
Analyzing lognormal data: A nonmathematical practical guide	17
Targeting Epidermal Growth Factor Receptor for Cancer Treatment: Abolishing Both Kinase-Dependent and Kinase-Independent Functions of the Receptor	16
International Union of Basic and Clinical Pharmacology CXV: The Class F of G Protein-Coupled Receptors	16
Pharmacological Regulation of Endoplasmic Reticulum Structure and Calcium Dynamics: Importance for Neurodegenerative Diseases	16
Precision Medicine in Rheumatic Diseases: Unlocking the Potential of Antibody-Drug Conjugates	15
Pharmacological Approaches to Hearing Loss	15
Leveraging Lymphatic System Targeting in Systemic Lupus Erythematosus for Improved Clinical Outcomes	14

Turn On, Tune In, Turnover! Target Biology Impacts In Vivo Potency, Efficacy, and Clearance	14
Summing Up Pharmacological Reviews’ 75th Anniversary Year and a Look to the Future	14
Table of Contents	14
Antipsychotics and dietary interventions: pharmacodynamics, pharmacokinetics and synergisms in therapy	14
Editorial Board	13
Emergence of Extracellular Vesicles as “Liquid Biopsy” for Neurological Disorders: Boom or Bust	13
Pharmacology and Precision Medicine—Preparing for the Next Era in Clinical Medicine—Editorial	13
Lymphocyte Depleting and Modulating Therapies for Chronic Lung Allograft Dysfunction	13
Inhaled Medicines: Past, Present, and Future	12
Changing Cerebral Blood Flow, Glucose Metabolism, and Dopamine Binding Through Transcranial Magnetic Stimulation: A Systematic Review of Transcranial Magnetic Stimulation-Positron Emission Tomography	12
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels	12
Pharmacological therapies for male infertility	12
A 25-Year Journey as Author and Associate Editor of Pharmacological Reviews—Editorial	11
Pharmacologic treatments for gastroparesis	11
A Chance to Grow and Excel as an Associate Editor of Pharmacological Reviews—Editorial	11
Topically Applied Therapies for the Treatment of Skin Disease: Past, Present, and Future	10
Multi- and polypharmacology of carbonic anhydrase inhibitors	10
Editorial Board	10
Ferroptosis and pathogenesis of neuritic plaques in Alzheimer disease	9
Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies	9
International Union of Basic and Clinical Pharmacology. CXVII: Taste 2 receptors—Structures, functions, activators, and blockers	9
Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials	9
Bioactives from marine resources as natural health products: A review	9
Steatotic Liver Disease: Pathophysiology and Emerging Pharmacotherapies	9
Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4	9
ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain	8
Cyclic nucleotide phosphodiesterases as drug targets	8
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies	8
The Molecular Biology of Phosphodiesterase 4 Enzymes as Pharmacological Targets: An Interplay of Isoforms, Conformational States, and Inhibitors	8
Table of Contents	7
Reversing the odds: Advanced and emerging therapeutic strategies for male infertility	7
Corrigendum to “Cell cycle dysregulation in cancer” [Pharmacological Reviews 77 (2025) 100030]	7
Announcement	7
Cytochrome P450 Enzymes: The Old Pandora’s Box with an Ever-Growing Hope for Therapy Optimization and Drug Development—Editorial	7
Nitric Oxide Signaling and Regulation in the Cardiovascular System: Recent Advances	6
International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology	6
Pharmacological treatment for metabolic dysfunction–associated steatotic liver disease and related disorders: Current and emerging therapeutic options	6
Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential	5
Table of Contents	5
Generation of Comprehensive GPCR-Transducer-Deficient Cell Lines to Dissect the Complexity of GPCR Signaling	5
Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction	4
Toward a paradigm shift: Oral agents and injectable drugs in the future of obesity management	4
Pharmacological Targeting of Mitochondria in Diabetic Kidney Disease	4
Application of Kirchhoff’s Laws to pharmacologic and pharmacokinetic analyses	4
Editorial Board	3
Editorial Board	3