OOIR: Observatory of International Research

Papers

(The median citation count of Pharmacological Reviews is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Innovative therapeutics for renoprotection: Where we are	433
Seventy-Five Years of Interactions: The Department of Physiology and Pharmacology at Karolinska Institutet and Pharmacological Reviews	426
The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes	259
The Nitrogen Mustards	205
Reimagining pharmacology education	187
The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics	161
Review of Natural Language Processing in Pharmacology	152
Therapeutic advantage of combinatorial chimeric antigen receptor T cell and chemotherapies	138
Table of Contents	124
Table of Contents	123
Metal-based antibody, nanobody, and peptide conjugates: Potential for breast cancer therapy	123
Carbonic anhydrase inhibitors: “Old” drugs with new potential in unexpected areas	115
The endocannabinoidomes: Pharmacological redundancy and promiscuity, and multi-kingdom variety of sources and molecular targets	110
Table of Contents	109
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023	102
Pharmaceutical perspectives on oligonucleotide therapeutics and delivery systems	102
Pharmacology and therapeutics of bile acid synthesis and modification enzymes in metabolic diseases	90
Optical Approaches for Investigating Neuromodulation and G Protein–Coupled Receptor Signaling	84
Innovation in cancer pharmacotherapy through integrative consideration of germline and tumor genomes	79
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins	79
Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer	73
Targeting of kinases to treat neurodegenerative diseases	70
Table of Contents	69
G Protein-Coupled Receptor Pharmacology—Insights from Mass Spectrometry	67
Asthma therapeutics: Past, present, and future	66

miR-155 aberrant expression impairs tumor rejection because of its targeting of ICOSL and multiple pathways implicated in the antitumor response	61
The Hippo pathway: Organ size control and beyond	60
Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response	60
Therapeutic Potential of Targeting Prokineticin Receptors in Diseases	60
Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism	60
Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications	57
Sulfotransferase 2B1b, Sterol Sulfonation, and Disease	56
Corrigendum to “International Union of Basic and Clinical Pharmacology. CXIX. Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes” [Pharmacologic	56
From neuroimmune circuits to targeted therapy of chronic pruritus	54
Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood	52
Nonhormonal Male Contraceptive Development—Strategies for Progress	52
Disulfidptosis: A novel cell death mechanism with pathological significance and therapeutic potential in diseases	51
Neurobiology of the incubation of drug craving: An update	51
Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy	51
Pharmacological Reviews’ 75th Year Anniversary: Past and Future—Editorial	49
Editorial Board	49
Dopamine, Immunity, and Disease	49
Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming	47
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications	47
Animal Behavior in Psychedelic Research	44
International Union of Basic and Clinical Pharmacology xxx: Applying an objective evaluation to the status of Class A orphan G protein-coupled receptors	44
Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks	43
Conotoxins Targeting Voltage-Gated Sodium Ion Channels	42
Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting	40
Vitamin D and its analogs in immune system regulation	38
Pharmacological strategies to bridge the gap between cancer and cardiovascular therapeutics	37
Table of Contents	37
Erratum to “Advances and challenges in experimental models of posttraumatic epilepsy for therapeutic interventions” [Pharmacological Reviews 77 (2025) 100080]	34
The Development of Cannabinoids as Therapeutic Agents in the United States	34
Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity	34
Harnessing multiomics technologies and machine learning for advancing personalized theranostic approaches in atherosclerosis	33
Potassium Channels in Parkinson’s Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment	32
International Union of Basic and Clinical Pharmacology. CXVIII. Update on the nomenclature for atypical chemokine receptors, including ACKR5	31
Epithelial cells in chronic obstructive pulmonary disease exacerbations: Targets for lung repair	30
Table of Contents	30
Drugging dancing protein clouds: A close look at disorder-based drug design	30
Carbon dots for drug delivery: Insights into their potential in nanopharmacology	28
Modeling lung transporters and their influence on inhaled drug disposition	28
Table of Contents	27
Synergistic combinations of antimicrobial peptides and conventional antibiotics: A strategy to delay resistance emergence in World Health Organization priority bacteria	27
Development of small molecule inhibitors of hypoxia-inducible factors for cancer therapy	26
Anticoagulants: From chance discovery to structure-based design	26
From bone sentinel to immune savant: Vitamin D and its receptor’s pharmacology	24
Adrenoceptor Desensitization: Current Understanding of Mechanisms	24
The complement system: Biology, pathology, and therapeutic interventions	24
International Union of Basic and Clinical Pharmacology. CXX. γ-Hydroxybutyrate protein targets in the mammalian brain—beyond classic receptors	23
Antipsychotics and dietary interventions: Pharmacodynamics, pharmacokinetics, and synergisms in therapy	23
Precision Medicine in Rheumatic Diseases: Unlocking the Potential of Antibody-Drug Conjugates	22
The evolution of lipid-lowering drugs in the management of cardiovascular disease risk: From the first cardiovascular disease risk–reducing therapies to the novel challenging strategies	22
Turn On, Tune In, Turnover! Target Biology Impacts In Vivo Potency, Efficacy, and Clearance	22

Novel and Emerging Treatments to Target Pathophysiological Mechanisms in Various Phenotypes of Multiple Sclerosis	22
Pharmacological Regulation of Endoplasmic Reticulum Structure and Calcium Dynamics: Importance for Neurodegenerative Diseases	21
International Union of Basic and Clinical Pharmacology CXV: The Class F of G Protein-Coupled Receptors	21
Targeting Epidermal Growth Factor Receptor for Cancer Treatment: Abolishing Both Kinase-Dependent and Kinase-Independent Functions of the Receptor	21
Friend or Foe? Glial-Vascular Interactions in Health and Neurodegenerative Disease	21
Pharmacological Approaches to Hearing Loss	21
Drug-Drug Interactions and Synergy: From Pharmacological Models to Clinical Application	21
Summing Up Pharmacological Reviews’ 75th Anniversary Year and a Look to the Future	20
Analyzing lognormal data: A nonmathematical practical guide	20
Emergence of Extracellular Vesicles as “Liquid Biopsy” for Neurological Disorders: Boom or Bust	19
Lymphocyte Depleting and Modulating Therapies for Chronic Lung Allograft Dysfunction	19
Pharmacology and Precision Medicine—Preparing for the Next Era in Clinical Medicine—Editorial	19
Senotherapy for chronic lung disease	18
Leveraging Lymphatic System Targeting in Systemic Lupus Erythematosus for Improved Clinical Outcomes	17
Changing Cerebral Blood Flow, Glucose Metabolism, and Dopamine Binding Through Transcranial Magnetic Stimulation: A Systematic Review of Transcranial Magnetic Stimulation-Positron Emission Tomography	17
Editorial Board	15
Pharmacological therapies for male infertility	15
A 25-Year Journey as Author and Associate Editor of Pharmacological Reviews—Editorial	15
A Chance to Grow and Excel as an Associate Editor of Pharmacological Reviews—Editorial	15
Fibroblasts—The emerging therapeutic target of the cardiovascular system?	14
Thrombin generation and the pharmacodynamics of parenteral anticoagulants	14
Steatotic Liver Disease: Pathophysiology and Emerging Pharmacotherapies	14
Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4	14
Pharmacologic treatments for gastroparesis	13
Topically Applied Therapies for the Treatment of Skin Disease: Past, Present, and Future	13
Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials	13
Translational Medications Development for Methamphetamine Use Disorder: A Systematic Review of Preclinical, Human Laboratory, and Clinical Research	13
Multi- and polypharmacology of carbonic anhydrase inhibitors	13
International Union of Basic and Clinical Pharmacology. CXVII: Taste 2 receptors—Structures, functions, activators, and blockers	12
Bioactives from marine resources as natural health products: A review	12
Platelet activation, aspirin, and cancer: From basic science to clinical trials	12
ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain	11
Cyclic nucleotide phosphodiesterases as drug targets	11
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies	11
Ferroptosis and pathogenesis of neuritic plaques in Alzheimer disease	11
Cytochrome P450 Enzymes: The Old Pandora’s Box with an Ever-Growing Hope for Therapy Optimization and Drug Development—Editorial	11
Pharmacological modulation of the blood-brain barrier: Mechanisms, therapeutic strategies, and emerging technologies	10
Reversing the odds: Advanced and emerging therapeutic strategies for male infertility	10
Corrigendum to “Cell cycle dysregulation in cancer” [Pharmacological Reviews 77 (2025) 100030]	10
Table of Contents	10
Links between COVID-19, long COVID, and neurodegeneration: The role of glycosphingolipids	9
Nitric Oxide Signaling and Regulation in the Cardiovascular System: Recent Advances	9
From physiopathology to treatment of familial hypercholesterolemia: Existing and emerging pharmacotherapies	9
Table of Contents	9
Pharmacological treatment for metabolic dysfunction–associated steatotic liver disease and related disorders: Current and emerging therapeutic options	9
The neuropharmacological basis of placebo analgesia: Mechanisms and clinical applications in the context of chronic pain	9
Erratum to “Edaravone: Advances on cytoprotective effects, pharmacological properties, and mechanisms of action” [Pharmacological Reviews 78 (2025) 100101]	8
Generation of Comprehensive GPCR-Transducer-Deficient Cell Lines to Dissect the Complexity of GPCR Signaling	8
Editorial Board	8
Neuropeptides as transmitters and regulators of the locus coeruleus noradrenergic system	8
Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction	8
Pharmacological Targeting of Mitochondria in Diabetic Kidney Disease	8
International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology	8
Physiological functions and pharmacological targeting of transient receptor potential channels	8
Waking up to the evidence of pharmacological treatments used to manage sleep disorders in people with dementia and mild cognitive impairment—A scoping review	7
Genetic therapies for neurological diseases	7
Immunomodulatory effects of calorie restriction and its mimetics: A new potential therapeutic approach for autoimmune diseases	7
Application of Kirchhoff’s Laws to pharmacologic and pharmacokinetic analyses	7
Editorial Board	7
Immunomodulatory and anticancer effects of phytochemicals: A comprehensive analysis	6
Mast Cell Proteases and Their Significance in Physiology, Pathology, and Therapeutic Approaches	6
Hepatic Bile Formation: Developing a New Paradigm	6
How dopamine guides our social world	6
Toward a paradigm shift: Oral agents and injectable drugs in the future of obesity management	6
Prospects for the convergence of polyphenols with pharmaceutical drugs in type 2 diabetes: Challenges, risks, and strategies	6