OOIR: Observatory of International Research

Papers

(The median citation count of Pharmacological Reviews is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies	482
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels	322
Rescuing the Last-Line Polymyxins: Achievements and Challenges	217
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development	187
Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials	165
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function	165
Subcellular Organization of the cAMP Signaling Pathway	164
Matrix Metalloproteinases: From Molecular Mechanisms to Physiology, Pathophysiology, and Pharmacology	134
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms	125
Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics	107
Post-Translational Modifications of G Protein–Coupled Receptors Control Cellular Signaling Dynamics in Space and Time	101
Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950	98
Sex- and Gender-Based Pharmacological Response to Drugs	97
Dopamine, Immunity, and Disease	92
International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update	86
Structure-Based Virtual Screening for Ligands of G Protein–Coupled Receptors: What Can Molecular Docking Do for You?	84
Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review	77
Ontogeny of Hepatic Transporters and Drug-Metabolizing Enzymes in Humans and in Nonclinical Species	74
Mutations in G Protein–Coupled Receptors: Mechanisms, Pathophysiology and Potential Therapeutic Approaches	74
Aldo-Keto Reductases and Cancer Drug Resistance	72
Unlocking G-Quadruplexes as Antiviral Targets	69
Animal Models of Drug Relapse and Craving after Voluntary Abstinence: A Review	66
E1 Enzymes as Therapeutic Targets in Cancer	62
Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications	60
Inhaled Medicines: Past, Present, and Future	56

Interaction of Cardiovascular Nonmodifiable Risk Factors, Comorbidities and Comedications With Ischemia/Reperfusion Injury and Cardioprotection by Pharmacological Treatments and Ischemic Conditioning	53
ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain	53
Neurobiological Mechanisms of Nicotine Reward and Aversion	50
Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications	50
Therapeutics in the Pipeline Targetingα-Synuclein for Parkinson's Disease	48
Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction	46
Therapeutic Targeting of α7 Nicotinic Acetylcholine Receptors	46
Sex/Gender Differences in the Time-Course for the Development of Substance Use Disorder: A Focus on the Telescoping Effect	44
Nonantimicrobial Actions of Macrolides: Overview and Perspectives for Future Development	43
The Angiotensin AT₂Receptor: From a Binding Site to a Novel Therapeutic Target	43
The Molecular Biology of Phosphodiesterase 4 Enzymes as Pharmacological Targets: An Interplay of Isoforms, Conformational States, and Inhibitors	42
Pharmacological Manipulation of Translation as a Therapeutic Target for Chronic Pain	42
Gαs–Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling	42
Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders	40
Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years	40
The Yin and Yang of ERBB4: Tumor Suppressor and Oncoprotein	40
International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors	39
Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions	39
Pharmacological Targeting of Mitochondria in Diabetic Kidney Disease	33
Pharmacogenomics: Driving Personalized Medicine	33
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications	32
Neural Mechanisms and Psychology of Psychedelic Ego Dissolution	31
Targeting the Adaptive Immune System in Depression: Focus on T Helper 17 Cells	31
Cognitive Impairment in Older Adults and Therapeutic Strategies	31
Pharmacology of Heparin and Related Drugs: An Update	30
Organotypic and Microphysiological Human Tissue Models for Drug Discovery and Development—Current State-of-the-Art and Future Perspectives	30
Analgesic Potential of Terpenes Derived fromCannabis sativa	30
Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight	30
β−Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives	29
Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response	28
Understanding the Neural Mechanisms of General Anesthesia from Interaction with Sleep–Wake State: A Decade of Discovery	27
Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease	26
Newly Developed Targeted Therapies Against the Androgen Receptor in Triple-Negative Breast Cancer: A Review	26
Current and Emerging Pharmacological Targets and Treatments of Urinary Incontinence and Related Disorders	25
The Nitrogen Mustards	24
The Emerging Role of the Innate Immune Response in Idiosyncratic Drug Reactions	24
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies	23
Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting	23
New Technologies Bloom Together for Bettering Cancer Drug Conjugates	20
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins	19
Allosteric Modulators of Metabotropic Glutamate Receptors as Novel Therapeutics for Neuropsychiatric Disease	18
Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy	18
α6-Containing GABA_AReceptors: Functional Roles and Therapeutic Potentials	18
Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential	17
ABCB1 and ABCG2 Regulation at the Blood-Brain Barrier: Potential New Targets to Improve Brain Drug Delivery	17
Potassium Channels in Parkinson’s Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment	16
L-Type Calcium Channel Blockers: A Potential Novel Therapeutic Approach to Drug Dependence	16
Viral G Protein–Coupled Receptors: Attractive Targets for Herpesvirus-Associated Diseases	15
Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection	15
Quantitative Proteomics in Translational Absorption, Distribution, Metabolism, and Excretion and Precision Medicine	15

Brain Cancer Drug Discovery: Clinical Trials, Drug Classes, Targets, and Combinatorial Therapies	15
Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer	14
New Aspects of Diabetes Research and Therapeutic Development	13
Therapeutic Opportunities and Delivery Strategies for Brain Revascularization in Stroke, Neurodegeneration, and Aging	13
Pharmacological Modulation of Immune Responses by Nutritional Components	12
Targeting Epidermal Growth Factor Receptor for Cancer Treatment: Abolishing Both Kinase-Dependent and Kinase-Independent Functions of the Receptor	12
Pharmacological Regulation of Endoplasmic Reticulum Structure and Calcium Dynamics: Importance for Neurodegenerative Diseases	11
Self-Entropic Broadening Theory: Toward a New Understanding of Self and Behavior Change Informed by Psychedelics and Psychosis	11
Changing Cerebral Blood Flow, Glucose Metabolism, and Dopamine Binding Through Transcranial Magnetic Stimulation: A Systematic Review of Transcranial Magnetic Stimulation-Positron Emission Tomography	10
G Protein-Coupled Receptor Pharmacology—Insights from Mass Spectrometry	10
Halogenated Antimicrobial Agents to Combat Drug-Resistant Pathogens	10
Inhaled β2 Adrenergic Agonists and Other cAMP-Elevating Agents: Therapeutics for Alveolar Injury and Acute Respiratory Disease Syndrome?	10
Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood	9
Mass Spectrometry Approaches Empowering Neuropeptide Discovery and Therapeutics	9
Immunology and Technology of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines	9
Modeling Pharmacokinetic Natural Product–Drug Interactions for Decision-Making: A NaPDI Center Recommended Approach	9
Steatotic Liver Disease: Pathophysiology and Emerging Pharmacotherapies	9
Emergence of Extracellular Vesicles as “Liquid Biopsy” for Neurological Disorders: Boom or Bust	9
Positive Allosteric Modulators of Glycine Receptors and Their Potential Use in Pain Therapies	9