Pharmacological Reviews

(The median citation count of Pharmacological Reviews is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies386
Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options374
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels247
Is Oxytocin “Nature’s Medicine”?198
RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges192
Rescuing the Last-Line Polymyxins: Achievements and Challenges174
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development160
Subcellular Organization of the cAMP Signaling Pathway143
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function136
The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway134
Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials117
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms108
Matrix Metalloproteinases: From Molecular Mechanisms to Physiology, Pathophysiology, and Pharmacology98
Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics98
Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC95089
Sex- and Gender-Based Pharmacological Response to Drugs86
Post-Translational Modifications of G Protein–Coupled Receptors Control Cellular Signaling Dynamics in Space and Time86
On the Clinical Pharmacology of Reactive Oxygen Species72
Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review68
International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update68
Structure-Based Virtual Screening for Ligands of G Protein–Coupled Receptors: What Can Molecular Docking Do for You?66
Mutations in G Protein–Coupled Receptors: Mechanisms, Pathophysiology and Potential Therapeutic Approaches63
International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function62
Animal Models of Drug Relapse and Craving after Voluntary Abstinence: A Review61
Unlocking G-Quadruplexes as Antiviral Targets61
Ontogeny of Hepatic Transporters and Drug-Metabolizing Enzymes in Humans and in Nonclinical Species61
Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies60
E1 Enzymes as Therapeutic Targets in Cancer58
Dopamine, Immunity, and Disease56
Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications56
Aldo-Keto Reductases and Cancer Drug Resistance55
Inhaled Medicines: Past, Present, and Future46
Strategies to Modulate MicroRNA Functions for the Treatment of Cancer or Organ Injury44
Therapeutic Targeting of α7 Nicotinic Acetylcholine Receptors41
Therapeutics in the Pipeline Targetingα-Synuclein for Parkinson's Disease41
Neurobiological Mechanisms of Nicotine Reward and Aversion40
Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications39
Nonantimicrobial Actions of Macrolides: Overview and Perspectives for Future Development39
ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain38
Pharmacological Manipulation of Translation as a Therapeutic Target for Chronic Pain36
The Molecular Biology of Phosphodiesterase 4 Enzymes as Pharmacological Targets: An Interplay of Isoforms, Conformational States, and Inhibitors34
International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors33
The Angiotensin AT2Receptor: From a Binding Site to a Novel Therapeutic Target33
Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders32
The Yin and Yang of ERBB4: Tumor Suppressor and Oncoprotein31
Interaction of Cardiovascular Nonmodifiable Risk Factors, Comorbidities and Comedications With Ischemia/Reperfusion Injury and Cardioprotection by Pharmacological Treatments and Ischemic Conditioning31
Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions31
Gαs–Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling30
Development of Novel, Value-Based, Digital Endpoints for Clinical Trials: A Structured Approach Toward Fit-for-Purpose Validation28
Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight27
International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific27
Cognitive Impairment in Older Adults and Therapeutic Strategies24
Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease24
Sex/Gender Differences in the Time-Course for the Development of Substance Use Disorder: A Focus on the Telescoping Effect23
Organotypic and Microphysiological Human Tissue Models for Drug Discovery and Development—Current State-of-the-Art and Future Perspectives23
Analgesic Potential of Terpenes Derived fromCannabis sativa23
Targeting the Adaptive Immune System in Depression: Focus on T Helper 17 Cells22
Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction22
Neural Mechanisms and Psychology of Psychedelic Ego Dissolution21
The Emerging Role of the Innate Immune Response in Idiosyncratic Drug Reactions19
Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting19
Newly Developed Targeted Therapies Against the Androgen Receptor in Triple-Negative Breast Cancer: A Review19
Pharmacology of Heparin and Related Drugs: An Update19
Pharmacological Targeting of Mitochondria in Diabetic Kidney Disease19
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications19
Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response18
Pharmacogenomics: Driving Personalized Medicine16
β−Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives15
Viral G Protein–Coupled Receptors: Attractive Targets for Herpesvirus-Associated Diseases15
Current and Emerging Pharmacological Targets and Treatments of Urinary Incontinence and Related Disorders15
Understanding the Neural Mechanisms of General Anesthesia from Interaction with Sleep–Wake State: A Decade of Discovery14
α6-Containing GABAAReceptors: Functional Roles and Therapeutic Potentials14
The Nitrogen Mustards14
New Technologies Bloom Together for Bettering Cancer Drug Conjugates14
Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection14
Brain Cancer Drug Discovery: Clinical Trials, Drug Classes, Targets, and Combinatorial Therapies14
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins14
Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years14