OOIR: Observatory of International Research

Papers

(The median citation count of Pharmacological Reviews is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies	360
Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options	358
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels	234
Is Oxytocin “Nature’s Medicine”?	191
RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges	186
Rescuing the Last-Line Polymyxins: Achievements and Challenges	167
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development	156
Subcellular Organization of the cAMP Signaling Pathway	141
The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway	130
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function	127
Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials	108
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms	106
Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics	97
Matrix Metalloproteinases: From Molecular Mechanisms to Physiology, Pathophysiology, and Pharmacology	93
Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950	87
Post-Translational Modifications of G Protein–Coupled Receptors Control Cellular Signaling Dynamics in Space and Time	85
Sex- and Gender-Based Pharmacological Response to Drugs	81
On the Clinical Pharmacology of Reactive Oxygen Species	70
Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review	68
International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update	65
Structure-Based Virtual Screening for Ligands of G Protein–Coupled Receptors: What Can Molecular Docking Do for You?	62
Ontogeny of Hepatic Transporters and Drug-Metabolizing Enzymes in Humans and in Nonclinical Species	60
Mutations in G Protein–Coupled Receptors: Mechanisms, Pathophysiology and Potential Therapeutic Approaches	60
Unlocking G-Quadruplexes as Antiviral Targets	60
Animal Models of Drug Relapse and Craving after Voluntary Abstinence: A Review	59

International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function	58
Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies	58
E1 Enzymes as Therapeutic Targets in Cancer	58
Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications	54
Aldo-Keto Reductases and Cancer Drug Resistance	52
Inhaled Medicines: Past, Present, and Future	44
Strategies to Modulate MicroRNA Functions for the Treatment of Cancer or Organ Injury	44
Dopamine, Immunity, and Disease	44
Therapeutic Targeting of α7 Nicotinic Acetylcholine Receptors	41
Nonantimicrobial Actions of Macrolides: Overview and Perspectives for Future Development	39
Therapeutics in the Pipeline Targetingα-Synuclein for Parkinson's Disease	38
Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications	37
Neurobiological Mechanisms of Nicotine Reward and Aversion	37
ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain	36
Pharmacological Manipulation of Translation as a Therapeutic Target for Chronic Pain	34
The Molecular Biology of Phosphodiesterase 4 Enzymes as Pharmacological Targets: An Interplay of Isoforms, Conformational States, and Inhibitors	33
International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors	33
The Yin and Yang of ERBB4: Tumor Suppressor and Oncoprotein	31
The Angiotensin AT₂Receptor: From a Binding Site to a Novel Therapeutic Target	31
Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders	30
Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions	30
Interaction of Cardiovascular Nonmodifiable Risk Factors, Comorbidities and Comedications With Ischemia/Reperfusion Injury and Cardioprotection by Pharmacological Treatments and Ischemic Conditioning	29
Gαs–Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling	28
Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight	27
Development of Novel, Value-Based, Digital Endpoints for Clinical Trials: A Structured Approach Toward Fit-for-Purpose Validation	27
International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E₂Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific	26
Cognitive Impairment in Older Adults and Therapeutic Strategies	24
Organotypic and Microphysiological Human Tissue Models for Drug Discovery and Development—Current State-of-the-Art and Future Perspectives	23
Analgesic Potential of Terpenes Derived fromCannabis sativa	23
Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease	23
Sex/Gender Differences in the Time-Course for the Development of Substance Use Disorder: A Focus on the Telescoping Effect	21
Targeting the Adaptive Immune System in Depression: Focus on T Helper 17 Cells	21
Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction	20
The Emerging Role of the Innate Immune Response in Idiosyncratic Drug Reactions	19
Pharmacological Targeting of Mitochondria in Diabetic Kidney Disease	18
Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting	18
Neural Mechanisms and Psychology of Psychedelic Ego Dissolution	18
Newly Developed Targeted Therapies Against the Androgen Receptor in Triple-Negative Breast Cancer: A Review	17
Pharmacology of Heparin and Related Drugs: An Update	17
Pharmacogenomics: Driving Personalized Medicine	16
Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response	15
β−Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives	15
Viral G Protein–Coupled Receptors: Attractive Targets for Herpesvirus-Associated Diseases	15
New Technologies Bloom Together for Bettering Cancer Drug Conjugates	14
Current and Emerging Pharmacological Targets and Treatments of Urinary Incontinence and Related Disorders	14
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins	14
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications	14
α6-Containing GABA_AReceptors: Functional Roles and Therapeutic Potentials	14
Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years	13
Understanding the Neural Mechanisms of General Anesthesia from Interaction with Sleep–Wake State: A Decade of Discovery	13

The Nitrogen Mustards	13
Brain Cancer Drug Discovery: Clinical Trials, Drug Classes, Targets, and Combinatorial Therapies	13