OOIR: Observatory of International Research

Papers

(The TQCC of New England Journal of Medicine is 69. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)

Article	Citations
Clinical Characteristics of Coronavirus Disease 2019 in China	17791
A Novel Coronavirus from Patients with Pneumonia in China, 2019	17352
Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia	9707
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine	5843
First Case of 2019 Novel Coronavirus in the United States	3933
Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes	3097
Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction	2878
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy	2771
Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany	2767
Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients	2525
Hepatocellular Carcinoma	1972
Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients	1944
Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma	1880
Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma	1761
Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma	1751
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia	1629
Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia	1505
A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease	1499
Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma	1376
Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis	1330
Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer	1313
Machine Learning in Medicine	1228
Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction	1191
Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive Advanced Breast Cancer	1145
Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer	1107
Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer	1084
Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction	1067
A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics	965
Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer	901
Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors	897
Nintedanib in Progressive Fibrosing Interstitial Lung Diseases	877
Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma	874
Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease	866
A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy	858
Elexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele	849
Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer	790
Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation	784
Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes	743
Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity	727
Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease	727
Ambient Particulate Air Pollution and Daily Mortality in 652 Cities	719
Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer	700
Low-Dose Methotrexate for the Prevention of Atherosclerotic Events	697
Encorafenib, Binimetinib, and Cetuximab in BRAF V600E–Mutated Colorectal Cancer	680
Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation	654
Five-Year Outcomes with Dabrafenib plus Trametinib in Metastatic Melanoma	649
Erdafitinib in Locally Advanced or Metastatic Urothelial Carcinoma	640
Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus	635
Apalutamide for Metastatic, Castration-Sensitive Prostate Cancer	635
Angiotensin–Neprilysin Inhibition in Acute Decompensated Heart Failure	627
A Fully Magnetically Levitated Left Ventricular Assist Device — Final Report	622
Effects of Intermittent Fasting on Health, Aging, and Disease	606
The “All of Us” Research Program	576
Gilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AML	576
Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant	559
Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma	549
Ticagrelor with or without Aspirin in High-Risk Patients after PCI	543
Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer	533
Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors	520
Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke	488
Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis	484
Overall Survival with Ribociclib plus Endocrine Therapy in Breast Cancer	481
Darolutamide in Nonmetastatic, Castration-Resistant Prostate Cancer	477
Apixaban to Prevent Venous Thromboembolism in Patients with Cancer	473
Veliparib with First-Line Chemotherapy and as Maintenance Therapy in Ovarian Cancer	470
Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions	458
Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura	456
The Imperative for Climate Action to Protect Health	453
Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis	438
Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source	436
Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes	435
Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes	421
Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome	418
Discrimination, Abuse, Harassment, and Burnout in Surgical Residency Training	415
Ibrutinib–Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia	414
Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer	406
Five-Year Outcomes after PCI or CABG for Left Main Coronary Disease	401
Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus	398
Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma	397
Eculizumab in Aquaporin-4–Positive Neuromyelitis Optica Spectrum Disorder	396
Targeting Huntingtin Expression in Patients with Huntington’s Disease	396
Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer	392
Oral versus Intravenous Antibiotics for Bone and Joint Infection	380
An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes	378
Complete Revascularization with Multivessel PCI for Myocardial Infarction	376
Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol	364
Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer	361
Oral Selinexor–Dexamethasone for Triple-Class Refractory Multiple Myeloma	353
Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease	351
Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis	343
Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19	339
Vedolizumab versus Adalimumab for Moderate-to-Severe Ulcerative Colitis	338
Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm	338
Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease	327
A Genotype-Guided Strategy for Oral P2Y₁₂ Inhibitors in Primary PCI	320
Diagnostic Utility of Exome Sequencing for Kidney Disease	319
Vitamin D Supplementation and Prevention of Type 2 Diabetes	310
Dolutegravir plus Two Different Prodrugs of Tenofovir to Treat HIV	309
Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis	306
Cabazitaxel versus Abiraterone or Enzalutamide in Metastatic Prostate Cancer	300
Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis	300
Ibrutinib and Venetoclax for First-Line Treatment of CLL	299
A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease	293
Persistence of Zika Virus in Body Fluids — Final Report	292
Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation	289
Coronary Angiography after Cardiac Arrest without ST-Segment Elevation	289
Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine	281
Trial of Satralizumab in Neuromyelitis Optica Spectrum Disorder	280
20-Year Follow-up of Statins in Children with Familial Hypercholesterolemia	272
Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome	269
Zika Virus Infection — After the Pandemic	268
Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes	268
Pheochromocytoma and Paraganglioma	266
Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease	265
Supplemental MRI Screening for Women with Extremely Dense Breast Tissue	261
Gene Therapy	260
A Randomized Trial of Lymphadenectomy in Patients with Advanced Ovarian Neoplasms	259
Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus	258
Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer	257
Bilateral versus Single Internal-Thoracic-Artery Grafts at 10 Years	256
Mobile Devices and Health	255
Acute Infection and Myocardial Infarction	254
Drug-Induced Liver Injury — Types and Phenotypes	251
Contrast-Associated Acute Kidney Injury	249
CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia	248
Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection	245
Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease	244
Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma	243
Endoscopic or Surgical Myotomy in Patients with Idiopathic Achalasia	243
Intravenous Iron in Patients Undergoing Maintenance Hemodialysis	237
Acquired Resistance to KRAS^G12C Inhibition in Cancer	233
Aspiration Pneumonia	232
Final Analysis of a Trial of M72/AS01_E Vaccine to Prevent Tuberculosis	232
Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas	230
Neural-Tube Defects with Dolutegravir Treatment from the Time of Conception	229
Pathology of Vaping-Associated Lung Injury	229
Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer	229
No Shortcuts to Safer Opioid Prescribing	225
Abatacept for Severe Immune Checkpoint Inhibitor–Associated Myocarditis	223
Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease	222
Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy	221
Early Sedation with Dexmedetomidine in Critically Ill Patients	220
Anemia of Inflammation	217
Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients	215
Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy	213
Neural-Tube Defects and Antiretroviral Treatment Regimens in Botswana	211
Procedural Volume and Outcomes for Transcatheter Aortic-Valve Replacement	209
Randomized Trial of Platelet-Transfusion Thresholds in Neonates	209
Tagraxofusp in Blastic Plasmacytoid Dendritic-Cell Neoplasm	208
Trends in Adolescent Vaping, 2017–2019	207
SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination	207
A Trial of a Shorter Regimen for Rifampin-Resistant Tuberculosis	204
HLA-B13:01*and the Dapsone Hypersensitivity Syndrome	204
Ticagrelor in Patients with Stable Coronary Disease and Diabetes	203
Obstructive Sleep Apnea in Adults	202
Detection of Brain Activation in Unresponsive Patients with Acute Brain Injury	200
Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART)	199
Treating Disease at the RNA Level with Oligonucleotides	195
Evidence of Artemisinin-Resistant Malaria in Africa	191
New Guidelines for Statistical Reporting in the Journal	188
Open versus Endovascular Repair of Abdominal Aortic Aneurysm	188
Schizophrenia	187
Understanding Links among Opioid Use, Overdose, and Suicide	187
Helicobacter pylori Infection	185
Update on Clinical Aspects of Chronic Obstructive Pulmonary Disease	184
Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure	182
Heatstroke	180
Antibacterial Envelope to Prevent Cardiac Implantable Device Infection	179
Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture	177
One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis	177
Two-Year Evaluation of Mandatory Bundled Payments for Joint Replacement	176
Ubrogepant for the Treatment of Migraine	175
Rimegepant, an Oral Calcitonin Gene–Related Peptide Receptor Antagonist, for Migraine	174
Neurodegenerative Disease Mortality among Former Professional Soccer Players	173
Application of High-Sensitivity Troponin in Suspected Myocardial Infarction	173
Life Expectancy after Bariatric Surgery in the Swedish Obese Subjects Study	173
Immune Thrombocytopenia	169
Five-Year Outcomes of Gastric Bypass in Adolescents as Compared with Adults	167
Mendelian Randomization Study of ACLY and Cardiovascular Disease	166
Muco-Obstructive Lung Diseases	165
Pulmonary Lipid-Laden Macrophages and Vaping	163
Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria	163
Placebo-Controlled Trial of an Oral BTK Inhibitor in Multiple Sclerosis	162
Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1	161
Lipid Management for the Prevention of Atherosclerotic Cardiovascular Disease	160
Tofacitinib in Amyopathic Dermatomyositis–Associated Interstitial Lung Disease	159
Randomized Delayed-Start Trial of Levodopa in Parkinson’s Disease	159
Global Elimination of Chronic Hepatitis	158
Secondary Surgical Cytoreduction for Recurrent Ovarian Cancer	158
Liraglutide in Children and Adolescents with Type 2 Diabetes	157
Clinical and Therapeutic Implications of Cancer Stem Cells	154
Esketamine for Treatment-Resistant Depression — First FDA-Approved Antidepressant in a New Class	153
Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism	152
Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis	151
Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability	150
Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents	149
A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants	149
Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception	149
Ligelizumab for Chronic Spontaneous Urticaria	146
Reanalysis of Clinical Exome Sequencing Data	145
A New Class of Medicines through DNA Editing	144
Organoids — Preclinical Models of Human Disease	144
Trial of Galcanezumab in Prevention of Episodic Cluster Headache	143
Chronic Kidney Disease of Unknown Cause in Agricultural Communities	141
Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa	141
Imaging of Vaping-Associated Lung Disease	140
Intensive Glucose Control in Patients with Type 2 Diabetes — 15-Year Follow-up	140
Early High-Dose Vitamin D₃ for Critically Ill, Vitamin D–Deficient Patients	139
Single-Dose Tafenoquine to Prevent Relapse ofPlasmodium vivaxMalaria	136
Universal Testing, Expanded Treatment, and Incidence of HIV Infection in Botswana	136
Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy	135
HIV Testing and Treatment with the Use of a Community Health Approach in Rural Africa	135
Screening for Prostate Cancer	134
Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy	134
Dolutegravir-Based or Low-Dose Efavirenz–Based Regimen for the Treatment of HIV-1	132
C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations	132
Adolescent Vaping and Nicotine Use in 2017–2018 — U.S. National Estimates	130
Benralizumab for the Prevention of COPD Exacerbations	130
Once-Daily Plazomicin for Complicated Urinary Tract Infections	129
Intimate Partner Violence	126
Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery	126
Management of Burns	125
Anterior Cruciate Ligament Tear	125
Depression in the Primary Care Setting	124
Tau Positron-Emission Tomography in Former National Football League Players	124
Early Convalescent Plasma for High-Risk Outpatients with Covid-19	123
Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer’s Disease	122
Plazomicin for Infections Caused by Carbapenem-Resistant Enterobacteriaceae	122
Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn	122
Effects of Serelaxin in Patients with Acute Heart Failure	122
Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure	122
Creating a Learning Health System through Rapid-Cycle, Randomized Testing	121
Pathogen Genomics in Public Health	120
Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria	119
Alemtuzumab for Immune-Related Myocarditis Due to PD-1 Therapy	118
A Randomized Trial of Intravenous Alteplase before Endovascular Treatment for Stroke	118
Omadacycline for Community-Acquired Bacterial Pneumonia	116
Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis	116
A Randomized Trial of Endometrial Scratching before In Vitro Fertilization	115
Platelet Counts during Pregnancy	114
Phase 3 Efficacy Analysis of a Typhoid Conjugate Vaccine Trial in Nepal	113
Stem Cells in the Treatment of Disease	111
Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis	111
Treatment Strategies for Deficiency of Adenosine Deaminase 2	110
Statewide Implementation of Postoperative Opioid Prescribing Guidelines	108
Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults	108
Benralizumab for PDGFRA-Negative Hypereosinophilic Syndrome	108
Randomized Trial of Four Treatment Approaches for Actinic Keratosis	107
Initial Opioid Prescriptions among U.S. Commercially Insured Patients, 2012–2017	106
Trial of SAGE-217 in Patients with Major Depressive Disorder	106
The Ongoing Ebola Epidemic in the Democratic Republic of Congo, 2018–2019	105
Changes in the Place of Death in the United States	105
Opioid Tolerance in Critical Illness	105
Soluble Urokinase Receptor and Acute Kidney Injury	104
Penicillin Allergy	104
Neurosyphilis	101
Omadacycline for Acute Bacterial Skin and Skin-Structure Infections	99
A New Segmented Virus Associated with Human Febrile Illness in China	99
Care of Transgender Persons	98
Adrenal Crisis	98
Addressing a Core Gap in Cancer Care — The NCI Moonshot Program to Help Oncology Patients Stop Smoking	98
Epidemiologic Signatures in Cancer	97
Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation	97
Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations	96
MRI-Targeted or Standard Biopsy in Prostate Cancer Screening	96
Measles in 2019 — Going Backward	96
Schistosomiasis — Assessing Progress toward the 2020 and 2025 Global Goals	95
C-Type Natriuretic Peptide Analogue Therapy in Children with Achondroplasia	95
Identification of Anonymous MRI Research Participants with Face-Recognition Software	95
SalmonellaTyphimurium Infections Associated with Peanut Products	94
Trial of Apremilast for Oral Ulcers in Behçet’s Syndrome	94
Molecular Genetic Anatomy and Risk Profile of Hirschsprung’s Disease	94
Mucinous Ovarian Carcinoma	93
Phase 3 Efficacy Trial of Modified Vaccinia Ankara as a Vaccine against Smallpox	93
Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers	92
Neuroprosthesis for Decoding Speech in a Paralyzed Person with Anarthria	90
Automated Identification of Adults at Risk for In-Hospital Clinical Deterioration	88
A Multicenter Trial of Vena Cava Filters in Severely Injured Patients	88
Genetic Variation, Comparative Genomics, and the Diagnosis of Disease	87
Polypill for Cardiovascular Disease Prevention in an Underserved Population	86
A Randomized Trial of Progesterone in Women with Bleeding in Early Pregnancy	81
Climate Change — A Health Emergency	80
Transmission of Nipah Virus — 14 Years of Investigations in Bangladesh	80
Metoprolol for the Prevention of Acute Exacerbations of COPD	80
Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency	79
Community-wide Screening for Tuberculosis in a High-Prevalence Setting	79
A Longitudinal Study of Ebola Sequelae in Liberia	78
Psychosis with Methylphenidate or Amphetamine in Patients with ADHD	78
Immunogenicity of Fractional-Dose Vaccine during a Yellow Fever Outbreak — Final Report	78
Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome	78
Decolonization to Reduce Postdischarge Infection Risk among MRSA Carriers	77
Antibody-Based Ticagrelor Reversal Agent in Healthy Volunteers	76
Donor Screening for Fecal Microbiota Transplantation	76
Saving the Endangered Physician-Scientist — A Plan for Accelerating Medical Breakthroughs	74
Maribavir for Preemptive Treatment of Cytomegalovirus Reactivation	74
Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level	74
Neurodevelopment in Infants Exposed to Zika Virus In Utero	72
Brain Tissue–Volume Changes in Cosmonauts	72
Hereditary Thrombotic Thrombocytopenic Purpura	71
Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease	71
Randomized Trial of Endoscopic or Open Vein-Graft Harvesting for Coronary-Artery Bypass	70
Inhaled GM-CSF for Pulmonary Alveolar Proteinosis	70
HER2 and Breast Cancer — A Phenomenal Success Story	69
Overall Survival with Fulvestrant plus Anastrozole in Metastatic Breast Cancer	69
Medical Journals and the 2019-nCoV Outbreak	69
Variant PADI3 in Central Centrifugal Cicatricial Alopecia	69