New England Journal of Medicine

(The TQCC of New England Journal of Medicine is 69. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)
Clinical Characteristics of Coronavirus Disease 2019 in China17791
A Novel Coronavirus from Patients with Pneumonia in China, 201917352
Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia9707
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine5843
First Case of 2019 Novel Coronavirus in the United States3933
Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes3097
Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction2878
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy2771
Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany2767
Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients2525
Hepatocellular Carcinoma1972
Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients1944
Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma1880
Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma1761
Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma1751
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia1629
Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia1505
A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease1499
Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma1376
Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis1330
Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer1313
Machine Learning in Medicine1228
Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction1191
Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive Advanced Breast Cancer1145
Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer1107
Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer1084
Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction1067
A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics965
Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer901
Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors897
Nintedanib in Progressive Fibrosing Interstitial Lung Diseases877
Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma874
Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease866
A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy858
Elexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele849
Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer790
Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation784
Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes743
Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity727
Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease727
Ambient Particulate Air Pollution and Daily Mortality in 652 Cities719
Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer700
Low-Dose Methotrexate for the Prevention of Atherosclerotic Events697
Encorafenib, Binimetinib, and Cetuximab in BRAF V600E–Mutated Colorectal Cancer680
Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation654
Five-Year Outcomes with Dabrafenib plus Trametinib in Metastatic Melanoma649
Erdafitinib in Locally Advanced or Metastatic Urothelial Carcinoma640
Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus635
Apalutamide for Metastatic, Castration-Sensitive Prostate Cancer635
Angiotensin–Neprilysin Inhibition in Acute Decompensated Heart Failure627
A Fully Magnetically Levitated Left Ventricular Assist Device — Final Report622
Effects of Intermittent Fasting on Health, Aging, and Disease606
The “All of Us” Research Program576
Gilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AML576
Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant559
Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma549
Ticagrelor with or without Aspirin in High-Risk Patients after PCI543
Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer533
Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors520
Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke488
Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis484
Overall Survival with Ribociclib plus Endocrine Therapy in Breast Cancer481
Darolutamide in Nonmetastatic, Castration-Resistant Prostate Cancer477
Apixaban to Prevent Venous Thromboembolism in Patients with Cancer473
Veliparib with First-Line Chemotherapy and as Maintenance Therapy in Ovarian Cancer470
Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions458
Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura456
The Imperative for Climate Action to Protect Health453
Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis438
Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source436
Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes435
Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes421
Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome418
Discrimination, Abuse, Harassment, and Burnout in Surgical Residency Training415
Ibrutinib–Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia414
Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer406
Five-Year Outcomes after PCI or CABG for Left Main Coronary Disease401
Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus398
Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma397
Eculizumab in Aquaporin-4–Positive Neuromyelitis Optica Spectrum Disorder396
Targeting Huntingtin Expression in Patients with Huntington’s Disease396
Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer392
Oral versus Intravenous Antibiotics for Bone and Joint Infection380
An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes378
Complete Revascularization with Multivessel PCI for Myocardial Infarction376
Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol364
Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer361
Oral Selinexor–Dexamethasone for Triple-Class Refractory Multiple Myeloma353
Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease351
Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis343
Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19339
Vedolizumab versus Adalimumab for Moderate-to-Severe Ulcerative Colitis338
Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm338
Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease327
A Genotype-Guided Strategy for Oral P2Y12 Inhibitors in Primary PCI320
Diagnostic Utility of Exome Sequencing for Kidney Disease319
Vitamin D Supplementation and Prevention of Type 2 Diabetes310
Dolutegravir plus Two Different Prodrugs of Tenofovir to Treat HIV309
Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis306
Cabazitaxel versus Abiraterone or Enzalutamide in Metastatic Prostate Cancer300
Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis300
Ibrutinib and Venetoclax for First-Line Treatment of CLL299
A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease293
Persistence of Zika Virus in Body Fluids — Final Report292
Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation289
Coronary Angiography after Cardiac Arrest without ST-Segment Elevation289
Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine281
Trial of Satralizumab in Neuromyelitis Optica Spectrum Disorder280
20-Year Follow-up of Statins in Children with Familial Hypercholesterolemia272
Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome269
Zika Virus Infection — After the Pandemic268
Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes268
Pheochromocytoma and Paraganglioma266
Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease265
Supplemental MRI Screening for Women with Extremely Dense Breast Tissue261
Gene Therapy260
A Randomized Trial of Lymphadenectomy in Patients with Advanced Ovarian Neoplasms259
Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus258
Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer257
Bilateral versus Single Internal-Thoracic-Artery Grafts at 10 Years256
Mobile Devices and Health255
Acute Infection and Myocardial Infarction254
Drug-Induced Liver Injury — Types and Phenotypes251
Contrast-Associated Acute Kidney Injury249
CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia248
Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection245
Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease244
Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma243
Endoscopic or Surgical Myotomy in Patients with Idiopathic Achalasia243
Intravenous Iron in Patients Undergoing Maintenance Hemodialysis237
Acquired Resistance to KRASG12C Inhibition in Cancer233
Aspiration Pneumonia232
Final Analysis of a Trial of M72/AS01E Vaccine to Prevent Tuberculosis232
Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas230
Neural-Tube Defects with Dolutegravir Treatment from the Time of Conception229
Pathology of Vaping-Associated Lung Injury229
Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer229
No Shortcuts to Safer Opioid Prescribing225
Abatacept for Severe Immune Checkpoint Inhibitor–Associated Myocarditis223
Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease222
Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy221
Early Sedation with Dexmedetomidine in Critically Ill Patients220
Anemia of Inflammation217
Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients215
Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy213
Neural-Tube Defects and Antiretroviral Treatment Regimens in Botswana211
Procedural Volume and Outcomes for Transcatheter Aortic-Valve Replacement209
Randomized Trial of Platelet-Transfusion Thresholds in Neonates209
Tagraxofusp in Blastic Plasmacytoid Dendritic-Cell Neoplasm208
Trends in Adolescent Vaping, 2017–2019207
SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination207
A Trial of a Shorter Regimen for Rifampin-Resistant Tuberculosis204
HLA-B*13:01and the Dapsone Hypersensitivity Syndrome204
Ticagrelor in Patients with Stable Coronary Disease and Diabetes203
Obstructive Sleep Apnea in Adults202
Detection of Brain Activation in Unresponsive Patients with Acute Brain Injury200
Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART)199
Treating Disease at the RNA Level with Oligonucleotides195
Evidence of Artemisinin-Resistant Malaria in Africa191
New Guidelines for Statistical Reporting in the Journal188
Open versus Endovascular Repair of Abdominal Aortic Aneurysm188
Understanding Links among Opioid Use, Overdose, and Suicide187
Helicobacter pylori Infection185
Update on Clinical Aspects of Chronic Obstructive Pulmonary Disease184
Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure182
Antibacterial Envelope to Prevent Cardiac Implantable Device Infection179
Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture177
One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis177
Two-Year Evaluation of Mandatory Bundled Payments for Joint Replacement176
Ubrogepant for the Treatment of Migraine175
Rimegepant, an Oral Calcitonin Gene–Related Peptide Receptor Antagonist, for Migraine174
Neurodegenerative Disease Mortality among Former Professional Soccer Players173
Application of High-Sensitivity Troponin in Suspected Myocardial Infarction173
Life Expectancy after Bariatric Surgery in the Swedish Obese Subjects Study173
Immune Thrombocytopenia169
Five-Year Outcomes of Gastric Bypass in Adolescents as Compared with Adults167
Mendelian Randomization Study of ACLY and Cardiovascular Disease166
Muco-Obstructive Lung Diseases165
Pulmonary Lipid-Laden Macrophages and Vaping163
Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria163
Placebo-Controlled Trial of an Oral BTK Inhibitor in Multiple Sclerosis162
Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1161
Lipid Management for the Prevention of Atherosclerotic Cardiovascular Disease160
Tofacitinib in Amyopathic Dermatomyositis–Associated Interstitial Lung Disease159
Randomized Delayed-Start Trial of Levodopa in Parkinson’s Disease159
Global Elimination of Chronic Hepatitis158
Secondary Surgical Cytoreduction for Recurrent Ovarian Cancer158
Liraglutide in Children and Adolescents with Type 2 Diabetes157
Clinical and Therapeutic Implications of Cancer Stem Cells154
Esketamine for Treatment-Resistant Depression — First FDA-Approved Antidepressant in a New Class153
Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism152
Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis151
Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability150
Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents149
A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants149
Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception149
Ligelizumab for Chronic Spontaneous Urticaria146
Reanalysis of Clinical Exome Sequencing Data145
A New Class of Medicines through DNA Editing144
Organoids — Preclinical Models of Human Disease144
Trial of Galcanezumab in Prevention of Episodic Cluster Headache143
Chronic Kidney Disease of Unknown Cause in Agricultural Communities141
Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa141
Imaging of Vaping-Associated Lung Disease140
Intensive Glucose Control in Patients with Type 2 Diabetes — 15-Year Follow-up140
Early High-Dose Vitamin D3 for Critically Ill, Vitamin D–Deficient Patients139
Single-Dose Tafenoquine to Prevent Relapse ofPlasmodium vivaxMalaria136
Universal Testing, Expanded Treatment, and Incidence of HIV Infection in Botswana136
Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy135
HIV Testing and Treatment with the Use of a Community Health Approach in Rural Africa135
Screening for Prostate Cancer134
Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy134
Dolutegravir-Based or Low-Dose Efavirenz–Based Regimen for the Treatment of HIV-1132
C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations132
Adolescent Vaping and Nicotine Use in 2017–2018 — U.S. National Estimates130
Benralizumab for the Prevention of COPD Exacerbations130
Once-Daily Plazomicin for Complicated Urinary Tract Infections129
Intimate Partner Violence126
Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery126
Management of Burns125
Anterior Cruciate Ligament Tear125
Depression in the Primary Care Setting124
Tau Positron-Emission Tomography in Former National Football League Players124
Early Convalescent Plasma for High-Risk Outpatients with Covid-19123
Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer’s Disease122
Plazomicin for Infections Caused by Carbapenem-Resistant Enterobacteriaceae122
Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn122
Effects of Serelaxin in Patients with Acute Heart Failure122
Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure122
Creating a Learning Health System through Rapid-Cycle, Randomized Testing121
Pathogen Genomics in Public Health120
Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria119
Alemtuzumab for Immune-Related Myocarditis Due to PD-1 Therapy118
A Randomized Trial of Intravenous Alteplase before Endovascular Treatment for Stroke118
Omadacycline for Community-Acquired Bacterial Pneumonia116
Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis116
A Randomized Trial of Endometrial Scratching before In Vitro Fertilization115
Platelet Counts during Pregnancy114
Phase 3 Efficacy Analysis of a Typhoid Conjugate Vaccine Trial in Nepal113
Stem Cells in the Treatment of Disease111
Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis111
Treatment Strategies for Deficiency of Adenosine Deaminase 2110
Statewide Implementation of Postoperative Opioid Prescribing Guidelines108
Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults108
Benralizumab for PDGFRA-Negative Hypereosinophilic Syndrome108
Randomized Trial of Four Treatment Approaches for Actinic Keratosis107
Initial Opioid Prescriptions among U.S. Commercially Insured Patients, 2012–2017106
Trial of SAGE-217 in Patients with Major Depressive Disorder106
The Ongoing Ebola Epidemic in the Democratic Republic of Congo, 2018–2019105
Changes in the Place of Death in the United States105
Opioid Tolerance in Critical Illness105
Soluble Urokinase Receptor and Acute Kidney Injury104
Penicillin Allergy104
Omadacycline for Acute Bacterial Skin and Skin-Structure Infections99
A New Segmented Virus Associated with Human Febrile Illness in China99
Care of Transgender Persons98
Adrenal Crisis98
Addressing a Core Gap in Cancer Care — The NCI Moonshot Program to Help Oncology Patients Stop Smoking98
Epidemiologic Signatures in Cancer97
Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation97
Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations96
MRI-Targeted or Standard Biopsy in Prostate Cancer Screening96
Measles in 2019 — Going Backward96
Schistosomiasis — Assessing Progress toward the 2020 and 2025 Global Goals95
C-Type Natriuretic Peptide Analogue Therapy in Children with Achondroplasia95
Identification of Anonymous MRI Research Participants with Face-Recognition Software95
SalmonellaTyphimurium Infections Associated with Peanut Products94
Trial of Apremilast for Oral Ulcers in Behçet’s Syndrome94
Molecular Genetic Anatomy and Risk Profile of Hirschsprung’s Disease94
Mucinous Ovarian Carcinoma93
Phase 3 Efficacy Trial of Modified Vaccinia Ankara as a Vaccine against Smallpox93
Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers92
Neuroprosthesis for Decoding Speech in a Paralyzed Person with Anarthria90
Automated Identification of Adults at Risk for In-Hospital Clinical Deterioration88
A Multicenter Trial of Vena Cava Filters in Severely Injured Patients88
Genetic Variation, Comparative Genomics, and the Diagnosis of Disease87
Polypill for Cardiovascular Disease Prevention in an Underserved Population86
A Randomized Trial of Progesterone in Women with Bleeding in Early Pregnancy81
Climate Change — A Health Emergency80
Transmission of Nipah Virus — 14 Years of Investigations in Bangladesh80
Metoprolol for the Prevention of Acute Exacerbations of COPD80
Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency79
Community-wide Screening for Tuberculosis in a High-Prevalence Setting79
A Longitudinal Study of Ebola Sequelae in Liberia78
Psychosis with Methylphenidate or Amphetamine in Patients with ADHD78
Immunogenicity of Fractional-Dose Vaccine during a Yellow Fever Outbreak — Final Report78
Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome78
Decolonization to Reduce Postdischarge Infection Risk among MRSA Carriers77
Antibody-Based Ticagrelor Reversal Agent in Healthy Volunteers76
Donor Screening for Fecal Microbiota Transplantation76
Saving the Endangered Physician-Scientist — A Plan for Accelerating Medical Breakthroughs74
Maribavir for Preemptive Treatment of Cytomegalovirus Reactivation74
Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level74
Neurodevelopment in Infants Exposed to Zika Virus In Utero72
Brain Tissue–Volume Changes in Cosmonauts72
Hereditary Thrombotic Thrombocytopenic Purpura71
Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease71
Randomized Trial of Endoscopic or Open Vein-Graft Harvesting for Coronary-Artery Bypass70
Inhaled GM-CSF for Pulmonary Alveolar Proteinosis70
HER2 and Breast Cancer — A Phenomenal Success Story69
Overall Survival with Fulvestrant plus Anastrozole in Metastatic Breast Cancer69
Medical Journals and the 2019-nCoV Outbreak69
Variant PADI3 in Central Centrifugal Cicatricial Alopecia69