OOIR: Observatory of International Research

Papers

(The TQCC of New England Journal of Medicine is 27. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Exclusion of Elective Care from Hospital Financial Assistance Policies — Arresting a Troubling Development	3733
Screening for Prostate Cancer	2332
Spontaneous Intracranial Hypotension	2053
Primaquine and Plasmodium vivax Malaria Recurrence in Brazil	1993
Malnutrition in Adults	1991
SENIOR-RITA — Is It All about Angiography?	1974
Early Active Mobilization during Mechanical Ventilation in the ICU	1939
Cerebral Embolic Protection during TAVI	1795
Transformative Research in Cystic Fibrosis	1740
Receipt of mRNA Vaccine against Covid-19 and Myocarditis	1707
Automated Insulin Pump in Type 2 Diabetes	1594
Automatic Insurance Policies — Important Tools for Preventing Coverage Loss	1585
Listening and Responding to Community Voices — The Community Wellness HUB	1447
Empagliflozin in Heart Failure with a Preserved Ejection Fraction	1336
Lung Transplantation for Covid-19–Related Respiratory Failure in the United States	1269
Gantenerumab in Early Alzheimer’s Disease	1228
Tenecteplase for Stroke — Opening the Window?	1206
Childhood Risk Factors and Adult Cardiovascular Events	1197
Threatening the Future of Global Health — NIH Policy Changes on International Research Collaborations	1177
Long-Term Outcomes of Resynchronization–Defibrillation for Heart Failure	1050
Debating Race and the Diagnosis of Anemia — How Medicine Moved Away from Race-Based Standards	1028
Case 18-2025: A 63-Year-Old Woman with Dyspnea on Exertion	997
Paget’s Disease of the Breast	926
A Modern Therapy for an Ancient Disease	897
Out of Pocket Getting Out of Hand — Reducing the Financial Toxicity of Rapidly Approved Drugs	892

From the Eyeball Test to the Algorithm — Quality of Life, Disability Status, and Clinical Decision Making in Surgery	890
Striking a Balance — Advancing Physician Collective-Bargaining Rights and Patient Protections	851
Hiding in Plain Sight	850
A Swell Diagnosis	807
Perioperative Durvalumab in Bladder Cancer	806
Asciminib in Newly Diagnosed Chronic Myeloid Leukemia	800
Postacute Sequelae of SARS-CoV-2 Infection in Several Eras	765
Targeting CSF1R in Chronic GVHD — Lessons in Translation	747
Race-Based Diagnosis, Part 1 — ITT Episode 33	744
Investigating Injustices in the Journal ’s History, Part 2	738
Hemotympanum with a Basilar Skull Fracture	737
Secondary Hypertrophic Osteoarthropathy	733
Intravenous Levothyroxine for Unstable Brain-Dead Heart Donors	731
Psychosocial Functioning in Transgender Youth after 2 Years of Hormones	720
Testing for Arginine Vasopressin Deficiency	714
U.S. Law and Discrimination in Health Care	706
Case 40-2022: A 38-Year-Old Man with Exertional Chest Discomfort	704
The Muffin Question	694
Bilothorax	687
Audio Interview: Assessing Bivalent Vaccines against Covid-19	683
Gingival Infiltration in Acute Monocytic Leukemia	676
Nonketotic Hyperglycemic Hemichorea	676
Hyperpigmentation in Vitamin B ₁₂ Deficiency	665
Ménétrier’s Disease	663
Rethinking Shadowing for Aspiring Physicians	660
Nationwide, Couple-Based Genetic Carrier Screening	658
Poet as Patient	655
Navigating and Communicating about Serious Illness and End of Life	651
Preparing for the Next Pandemic — Expanding and Coordinating Global Regulatory Capacity	643
Liver Transplantation for Mahvash Disease, an Inborn Error of Metabolism	635
Adrenal Involvement in Disseminated Histoplasmosis	622
Multicentric Reticulohistiocytosis	618
Zilebesiran for Hypertension	606
Timing Is Everything — Evidence for When to Perform Complete Revascularization in STEMI	599
Black Dot Tinea Capitis	599
Convalescent Rash of Dengue	591
Redefining Lung Cancer Therapy — A Long-Awaited Shift in Strategy	584
Bismuth Subsalicylate Poisoning	583
Early Treatment with Sotrovimab for Covid-19	574
Covid-19 Infections in Vaccinated Health Care Workers	573
Bumps in the Road	566
Catching Up on REMs	561
Foreign-Body Aspiration in a Child	561
Maintenance or Discontinuation of Antidepressants in Primary Care	557
Prolonging Cellular Life after Hypoxic Death	554
Middle Meningeal Artery Embolization for Subdural Hematoma	549
Cholelithiasis, Cholecystitis, and Choledocholithiasis	543
Gazing into a Crystal Ball	542
Breaking the Sacred Promise	538
Designing Cures 2.0 — From Corridors to Cornerstones	537

Monoclonal Antibodies in the Pathogenesis of Heparin-Induced Thrombocytopenia	537
Pistachio Ice Cream	537
Ten Years of Incidental, Secondary, and Actionable Findings	536
Turning CMS into a Health Technology Assessment Organization	531
How Can We Fully Realize SNAP’s Health Benefits?	529
Audio Interview: Dissecting the Host Response to SARS-CoV-2	526
Monoclonal Antibodies for Malaria	524
Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors for Anemia in CKD	519
Virotherapy for Brain Tumors — Defining the Path to Success	517
Measurable Residual Disease–Guided Therapy for Chronic Lymphocytic Leukemia	513
Optical Coherence Tomography and Eye Care	504
Mucosal IgA against SARS-CoV-2 Omicron Infection	502
A Trial of Trimethoprim–Sulfamethoxazole in Pregnancy to Improve Birth Outcomes	501
Permethrin-Treated Baby Wraps for the Prevention of Malaria	499
Hypothermia or Machine Perfusion in Kidney Donors	495
Gene Therapy with Fidanacogene Elaparvovec in Adults with Hemophilia B	492
Kidney Injury and Hair-Straightening Products Containing Glyoxylic Acid	491
Effect of a Reduced PCV10 Dose Schedule on Pneumococcal Carriage in Vietnam	490
Navigating and Communicating about Serious Illness and End of Life	483
Nutritional Support for Moderate-to-Late–Preterm Infants — A Randomized Trial	471
Evidence-Based Work Design — Bridging the Divide	466
Implanted System for Orthostatic Hypotension in Multiple-System Atrophy	463
Pulse Oximetry for Monitoring Patients with Covid-19 at Home — A Pragmatic, Randomized Trial	460
Modifiable Risk Factors and Cardiovascular Outcomes	452
Haloperidol for the Treatment of Delirium in ICU Patients	442
Sacituzumab Govitecan in Untreated, Advanced Triple-Negative Breast Cancer	440
Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR	427
BCMA-Targeted T-Cell Engager for Autoimmune Hemolytic Anemia after CD19 CAR T-Cell Therapy	425
Overcoming Resistance — Omission of Radiotherapy for Low-Risk Breast Cancer	424
Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD	419
Mepolizumab to Prevent Exacerbations of COPD with an Eosinophilic Phenotype	418
First-Line Venetoclax Combinations in Chronic Lymphocytic Leukemia	418
Lobar or Sublobar Resection for Peripheral Stage IA Non–Small-Cell Lung Cancer	417
Belantamab Mafodotin, Bortezomib, and Dexamethasone for Multiple Myeloma	417
Sotorasib in KRAS p.G12C–Mutated Advanced Pancreatic Cancer	417
Fever of Unknown Origin	416
Safety and Efficacy of Obicetrapib in Patients at High Cardiovascular Risk	413
Periprosthetic Joint Infection	406
Bronchiectasis — A Clinical Review	405
Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction	405
Use of Wastewater for Mpox Outbreak Surveillance in California	403
Dupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts	402
Reteplase versus Alteplase for Acute Ischemic Stroke	401
A Tale of Two Diseases	400
Hospital Problems	400
Ondansetron after ED Visits in Children with Gastroenteritis	396
Guidance on Energy and Macronutrients across the Life Span	394
Pretomanid in the Treatment of Patients with Tuberculosis in the United States	386
Extending Cancer Survival with Exercise — Time for Oncology to Act	386
Compared with What? Measuring AI against the Health Care We Have	385
Trials for Managing Acute Pain — A Clinically Meaningful Small Effect Size?	383
Focused Cardiac Ultrasonography for Right Ventricular Size and Systolic Function	381
New Perioperative Strategy in Gastric Cancer	380
Cholesterol Pericarditis	379
SGLT2 Inhibitors and False Positive Toxicology Tests	378
Case 38-2024: A 22-Year-Old Woman with Headache, Fever, and Respiratory Failure	377
Crinecerfont in Adult Congenital Adrenal Hyperplasia	377
Case 5-2023: A 67-Year-Old Man with Interstitial Lung Disease, Fever, and Myalgias	375
Personality Disorders	373
Atrial Fibrillation — What Is It and How Is It Treated?	371
Audio Interview: Rolling Out New Covid-19 Vaccines	371
HIV Prevention and the 340B Drug Pricing Program	364
Benefits and Risks of Iron Interventions in Infants in Bangladesh	364
Japanese Spotted Fever	364
Academic Freedom in America — In Support of Institutional Voices	363
Medication for Gastroesophageal Reflux Disease in Infants	363
Vocal-Cord Polyp Causing Airway Obstruction	362
Chylothorax	360
Broken Both Ways	359
Convalescent Plasma for Covid-19–Induced ARDS	357
A Physician Attack on the FDA — Will the Supreme Court Reduce Access to Mifepristone?	349
What We Don’t Know about School Shooter Drills	349
Case 21-2023: A 61-Year-Old Man with Eyelid Swelling	344
Public Health’s Role in a Post- Dobbs World — The New York City Abortion Access Hub	342
Intravenous Amino Acids and Kidney Protection	341
The Death of an Unlikable Man	341
Felzartamab in Antibody-Mediated Rejection	337
Routine Removal of Inferior Vena Cava Filters	335
Case 26-2022: A 48-Year-Old Woman with Cystic Lung Disease	333
Audio Interview: Ending the Covid-19 Public Health Emergency	333

Diagnostic Aspirations	333
End of a Declared Public Health Emergency — Implications for U.S. Emergency Use Authorizations	332
PD-1 and PD-L1 Blockade plus Chemotherapy in Endometrial Cancer	327
Guilty	327
Covid-19 Surveillance Testing in Nursing Homes	327
Water-Based and Waterless Surgical Scrub Techniques	326
Case 39-2023: A 43-Year-Old Woman with Chronic Diarrhea, Hair Loss, and Nail and Skin Changes	325
Expect With Me — Group Prenatal Care to Reduce Disparities	323
Tuberculous Meningitis — New Approaches Needed	322
Gastric Syphilis	321
Increasing Firearm-Related Deaths among U.S. Black Rural Youths	321
Risks and Benefits of Janus Kinase Inhibitors in Rheumatoid Arthritis — Past, Present, and Future	321
Laryngeal Candidiasis	318
Gustatory Hyperhidrosis after Parotid Surgery	318
Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction	317
Autoantibodies Targeting Nephrin in Podocytopathies	317
FINEARTS-HF — The Latest Masterpiece for MRAs in Heart Failure	316
Small Step or Giant Leap? Expanding the Acute Stroke Thrombolysis Window to 24 Hours	313
Association between Covid-19 Vaccination and Influenza Vaccination Rates	310
Targeting Lipoprotein(a) — the Next Frontier in Cardiovascular Disease	310
Occupational Health and Safety on the Chopping Block — What’s at Stake?	308
Can AI Solve Primary Care?	308
In Vitro Efficacy of Antiviral Agents against Omicron Subvariant BA.4.6	308
The Risks of Normalizing Parental Vaccine Hesitancy	302
Medication-Associated Diethylene Glycol Mass Poisoning — A Preventable Cause of Illness and Death	302
Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia	302
Mycoplasma-Induced Rash and Mucositis	300
What’s in a Number? Breaking Down the Residency Match Rate	298
“Putting America First” — Undermining Health for Populations at Home and Abroad	296
Transforming Management of Opioid Use Disorder with Universal Treatment	295
Making Long-Term Oxygen Therapy Less Burdensome	292
Booster Doses and Prioritizing Lives Saved	292
Criminalizing Homelessness — The Grants Pass, Oregon, Supreme Court Case	290
Pegylated Interferon Lambda for Covid-19	290
NEJM at AHA — Routine Spironolactone in Acute Myocardial Infarction	288
Safety and Efficacy of Denosumab for Fibrous Dysplasia of Bone	287
Neurovascular Complications of Iatrogenic Fusarium solani Meningitis	286
A Preview of the Dangerous Future of Abortion Bans — Texas Senate Bill 8	285
The IARC Perspective on Cervical Cancer Screening	284
Emodepside for Trichuris trichiura and Hookworm Infection	284
Bivalent Covid-19 Vaccines — A Cautionary Tale	282
Audio Interview: The Omicron Variant of SARS-CoV-2	280
The Increasing Incidence of Early-Onset Colorectal Cancer	280
Postherpetic Abdominal Pseudohernia	275
Integration of Tobacco-Cessation Interventions into Tuberculosis and HIV Care	275
Transfusion Strategy in Myocardial Infarction and Anemia	274
Methylprednisolone for Heart Surgery in Infants — A Randomized, Controlled Trial	274
Phase 1–2 Trial of AAVS3 Gene Therapy in Patients with Hemophilia B	273
Ultraprocessed Food on an Ultrafast Track	273
Invasive Strategy for Older Patients with MI	272
Fulminant Viral Myocarditis Associated with Thogotovirus	272
Targeting HER2 -Mutant NSCLC — The Light Is On	270
Genetically Modified Porcine-to-Human Cardiac Xenotransplantation	269
Apolipoprotein A1 Infusions and Cardiovascular Outcomes after Acute Myocardial Infarction	269
Prevalence of Mismatch-Repair Deficiency in Rectal Adenocarcinomas	266
Randomized Trial of Targeted Indoor Spraying to Prevent Aedes-Borne Diseases	264
Five-Year Outcomes of the Danish Cardiovascular Screening (DANCAVAS) Trial	264
Artificial Intelligence in Medicine	260
Disappearing Data at the U.S. Federal Government	260
Betibeglogene Autotemcel Gene Therapy for Non–β ⁰ /β ⁰ Genotype β-Thalassemia	257
A Zoonotic Henipavirus in Febrile Patients in China	256
Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension	255
Risk of Second Tumors and T-Cell Lymphoma after CAR T-Cell Therapy	255
Helicobacter pylori , Homologous-Recombination Genes, and Gastric Cancer	254
Cardiac Implantable Electronic Devices	253
Advanced HIV as a Neglected Disease	253
Transcatheter Valve Replacement in Severe Tricuspid Regurgitation	253
Glycemia Reduction in Type 2 Diabetes — Microvascular and Cardiovascular Outcomes	252
Moving the Needle on Alzheimer’s Disease with an Anti-Oligomer Antibody	251
Immune Checkpoint Inhibitors — The Need for Innovation	250
Waning Immunity after the BNT162b2 Vaccine in Israel	249
Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity	249
Chronic Traumatic Encephalopathy in the Brains of Military Personnel	249
Phase 3 Trial of Inhaled Molgramostim in Autoimmune Pulmonary Alveolar Proteinosis	249
Catheter Ablation in End-Stage Heart Failure with Atrial Fibrillation	248
Audio Interview: Ending the Covid-19 Emergency	248
Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction	247
Resistance Mutations in SARS-CoV-2 Delta Variant after Sotrovimab Use	246
Early Outpatient Treatment for Covid-19 with Convalescent Plasma	245
Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma	244
Acute Myeloid Leukemia Case after Gene Therapy for Sickle Cell Disease	242
Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer	242
Autoantibodies Targeting Nephrin in Podocytopathies	242
GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma	241
Efficacy and Safety of a Bivalent RSV Prefusion F Vaccine in Older Adults	241
Monkeypox	239
A Dual-Chamber Leadless Pacemaker	239
A Phase 2 Randomized Trial of Survodutide in MASH and Fibrosis	238
Behçet’s Syndrome	237
Genital Herpes Zoster	236
Health Care in an Evolving Immigration Landscape — Providing Care while Upholding the Law	234
Aspiration Thrombectomy for Coronary Stent Thrombosis	234
Daily Urinary Sodium and Potassium Excretion and Cardiovascular Risk	233
Dietary Sodium Restriction in Patients with Heart Failure	231
Case 1-2023: A 49-Year-Old Man with Hypokalemia and Paranoia	230